TY - JOUR A1 - Arazi, Hamid A1 - Asadi, Abbas A1 - Khalkhali, Farhood A1 - Boullosa, Daniel A1 - Hackney, Anthony C. A1 - Granacher, Urs A1 - Zouhal, Hassane T1 - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players BT - A Preliminary Study JF - Frontiers in Physiology N2 - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r 2) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season. KW - training load KW - rate of perceived exertion KW - rolling averages KW - weighted moving averages KW - football Y1 - 2020 U6 - https://doi.org/10.3389/fphys.2020.00995 SN - 1664-042X VL - 11 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Helm, Norman A1 - Prieske, Olaf A1 - Mühlbauer, Thomas A1 - Krüger, Tom A1 - Granacher, Urs T1 - Effects of judo-specific resistance training on kinetic and electromyographic parameters of pulling exercises in judo athletes T1 - Effekte eines judospezifischen Messplatztrainings auf kinetische und elektromyografische Parameter des Anreißens bei Wurfeingangsbewegungen von Judoka JF - Sportverletzung, Sportschaden : Grundlagen, Prävention, Rehabilitation N2 - Background In judo, rapid force production during pulling movements is an important component of athletic performance, which is why this capacity needs to be specifically exercised in judo. This study aimed at examining the effects of a judo-specific resistance training program using a judo ergometer system (PTJ) versus a traditional resistance training regime using a partner (PTP) on kinetics and muscle activity of judo-specific pulling exercises. Method Twenty-four male judo athletes (age: 22 +/- 4 years, training experience: 15 +/- 3 years) were randomly assigned to two groups. In a crossover design, the first group completed a 4-week PTJ followed by four weeks of PTP (each with three sessions per week). The second group conducted PTP prior to PTJ. PTJ and PTP were completed in addition to regular training. Before, 4 weeks and 8 weeks after training, tests were conducted to assess judo-specific pulling kinetics (i.e. maximal force, rate of force development [RFD], mechanical work) and electromyographic (EMG) shoulder/trunk muscle activity (i.e. biceps brachii muscle, deltoid muscle, trapezius muscle, erector spinae muscle) during pulling movements using a judo ergometer as well as unspecific strength tests (i.e. bench-pull, pull-ups). Results The statistical analysis revealed that in both groups ergometer pulling kinetics (p<.05, 0.83 <= d <= 1.77) and EMG activity (p<.05; 1.07 <= d <= 2.25) were significantly enhanced following 8 weeks of training. In addition, significantly larger gains in RFD, mechanical work, and EMG activity (i.e. deltoid muscle, erector spinae muscle, trapezius muscle) were found following PTJ compared to PTP (p<.05, 1.25 <= d <= 2.79). No significant enhancements were observed with the unspecific strength tests. Conclusion Our findings indicate that PTJ is superior to PTP regarding training-induced improvements in force production and muscle activity during judo-specific pulling exercises. Performance enhancements may partly be attributed to neural adaptations. No transfer effects on unspecific strength tests were detected following PTJ and PTP. N2 - Hintergrund Schnellkräftige Wurfeingangsbewegungen stellen im Judo entscheidende Voraussetzungen für den Wettkampferfolg dar, weshalb das Training der Anrissbewegung ein zentrales Element des judospezifischen Trainings darstellt. Das Ziel der Studie bestand darin, die Effekte eines Anrisstrainings mit einem Judoergometer-System (ATJ) gegenüber einem tradierten Anrisstraining mit Partner (ATP) auf kinetische und elektromyografische Parameter des Anreißens bei Wurfeingangsbewegungen von Judoka zu untersuchen. Methode Männliche leistungsorientierte Judoka (N = 24, Alter: 22 ± 4 Jahre; Trainingserfahrung: 15 ± 3 Jahre) wurden randomisiert in zwei Gruppen aufgeteilt. Im Crossover-Design absolvierte die erste Gruppe über vier Wochen ein ATJ gefolgt von vier Wochen ATP (je 3x/ Woche). Die zweite Gruppe führte beide Trainingsvarianten in umgekehrter Reihenfolge durch. ATJ und ATP wurden zusätzlich zum bestehenden Training absolviert. Vor dem Training sowie nach vier und nach acht Wochen Training wurden Tests zur Erfassung kinetischer Parameter (dynamisch-realisierte Maximalkraft, Explosivkraft, mechanische Arbeit) und elektromyografischer (EMG) Schulter-/ Rumpfmuskelaktivitäten (M. biceps brachii, M. deltoideus, M. trapezius, M. erector spinae) für die Hub- und Zugarmseite bei Wurfeingangsbewegungen am Judoergometer sowie sportartunspezifische Krafttests (d. h. Liegend-Anreißen, Klimmziehen) durchgeführt. Ergebnisse Die Ergebnisse der statistischen Analyse ergaben über den gesamten Interventionszeitraum (8 Wochen) für beide Trainingsgruppen signifikante Verbesserungen der kinetischen Parameter (p <,05; 0,83 ≤d≤ 1,77) und EMG-Aktivitäten (p <,05; 1,07 ≤d≤ 2,25). Darüber hinaus zeigten sich größere Zuwachsraten in der Explosivkraft, der mechanischen Arbeit und den Schulter-/Rumpfmuskelaktivitäten (M. deltoideus, M. erector spinae, M. trapezius) zugunsten von ATJ im Vergleich zu ATP (p <,05; 1,25 ≤d≤ 2,79). Für die sportartunspezifischen Kraftwerte wurden keine signifikanten Veränderungen festgestellt. Schlussfolgerung Die vorliegenden Ergebnisse zeigen, dass ATJ gegenüber ATP größere Steigerungsraten von kinetischen und elektromyografischen Parametern des Anreißens bei Wurfeingangsbewegungen von Judoka bewirkt. Die trainingsbedingten Leistungssteigerungen scheinen zumindest teilweise auf neuronalen Anpassungen zu beruhen. KW - combat sport KW - athletic performance KW - specific strength training KW - surface electromyography KW - Kampfsport KW - sportliche Leistung KW - spezifisches Krafttraining KW - Oberflächenelektromyografie Y1 - 2018 U6 - https://doi.org/10.1055/s-0043-122781 SN - 0932-0555 SN - 1439-1236 VL - 32 IS - 2 SP - 134 EP - 142 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Gäbler, Martijn A1 - Prieske, Olaf A1 - Hortobagyi, Tibor A1 - Granacher, Urs T1 - The Effects of Concurrent Strength and Endurance Training on Physical Fitness and Athletic Performance in Youth BT - A Systematic Review and Meta-Analysis JF - Frontiers in Physiology N2 - Combining training of muscle strength and cardiorespiratory fitness within a training cycle could increase athletic performance more than single-mode training. However, the physiological effects produced by each training modality could also interfere with each other, improving athletic performance less than single-mode training. Because anthropometric, physiological, and biomechanical differences between young and adult athletes can affect the responses to exercise training, young athletes might respond differently to concurrent training (CT) compared with adults. Thus, the aim of the present systematic review with meta-analysis was to determine the effects of concurrent strength and endurance training on selected physical fitness components and athletic performance in youth. A systematic literature search of PubMed and Web of Science identified 886 records. The studies included in the analyses examined children (girls age 6–11 years, boys age 6–13 years) or adolescents (girls age 12–18 years, boys age 14–18 years), compared CT with single-mode endurance (ET) or strength training (ST), and reported at least one strength/power—(e.g., jump height), endurance—(e.g., peak V°O2, exercise economy), or performance-related (e.g., time trial) outcome. We calculated weighted standardized mean differences (SMDs). CT compared to ET produced small effects in favor of CT on athletic performance (n = 11 studies, SMD = 0.41, p = 0.04) and trivial effects on cardiorespiratory endurance (n = 4 studies, SMD = 0.04, p = 0.86) and exercise economy (n = 5 studies, SMD = 0.16, p = 0.49) in young athletes. A sub-analysis of chronological age revealed a trend toward larger effects of CT vs. ET on athletic performance in adolescents (SMD = 0.52) compared with children (SMD = 0.17). CT compared with ST had small effects in favor of CT on muscle power (n = 4 studies, SMD = 0.23, p = 0.04). In conclusion, CT is more effective than single-mode ET or ST in improving selected measures of physical fitness and athletic performance in youth. Specifically, CT compared with ET improved athletic performance in children and particularly adolescents. Finally, CT was more effective than ST in improving muscle power in youth. KW - child KW - adolescent KW - muscle strength KW - cardiorespiratory fitness KW - physical conditioning human KW - resistance training KW - youth sports Y1 - 2018 U6 - https://doi.org/10.3389/fphys.2018.01057 SN - 1664-042X VL - 9 SP - 1 EP - 13 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Mühlbauer, Thomas A1 - Besemer, Carmen A1 - Wehrle, Anja A1 - Gollhofer, Albert A1 - Granacher, Urs T1 - Relationship between strength, power and balance performance in seniors JF - Gerontology N2 - Background: Deficits in strength, power and balance represent important intrinsic risk factors for falls in seniors. Objective: The purpose of this study was to investigate the relationship between variables of lower extremity muscle strength/power and balance, assessed under various task conditions. Methods: Twenty-four healthy and physically active older adults (mean age: 70 8 5 years) were tested for their isometric strength (i.e. maximal isometric force of the leg extensors) and muscle power (i.e. countermovement jump height and power) as well as for their steady-state (i.e. unperturbed standing, 10-meter walk), proactive (i.e. Timed Up & Go test, Functional Reach Test) and reactive (i.e. perturbed standing) balance. Balance tests were conducted under single (i.e. standing or walking alone) and dual task conditions (i.e. standing or walking plus cognitive and motor interference task). Results: Significant positive correlations were found between measures of isometric strength and muscle power of the lower extremities (r values ranged between 0.608 and 0.720, p < 0.01). Hardly any significant associations were found between variables of strength, power and balance (i.e. no significant association in 20 out of 21 cases). Additionally, no significant correlations were found between measures of steady-state, proactive and reactive balance or balance tests performed under single and dual task conditions (all p > 0.05). Conclusion: The predominately nonsignificant correlations between different types of balance imply that balance performance is task specific in healthy and physically active seniors. Further, strength, power and balance as well as balance under single and dual task conditions seem to be independent of each other and may have to be tested and trained complementarily. KW - Steady-state balance KW - Proactive/reactive balance KW - Force production KW - Single/dual tasking KW - Cognitive/motor interference Y1 - 2012 U6 - https://doi.org/10.1159/000341614 SN - 0304-324X VL - 58 IS - 6 SP - 504 EP - 512 PB - Karger CY - Basel ER - TY - JOUR A1 - Grabow, Lena A1 - Young, James D. A1 - Alcock, Lynsey R. A1 - Quigley, Patrick J. A1 - Byrne, Jeannette M. A1 - Granacher, Urs A1 - Skarabot, Jakob A1 - Behm, David George T1 - Higher Quadriceps Roller Massage Forces Do Not Amplify Range-of-Motion Increases nor Impair Strength and Jump Performance JF - Journal of strength and conditioning research : the research journal of the NSCA N2 - Grabow, L, Young, JD, Alcock, LR, Quigley, PJ, Byrne, JM, Granacher, U, Škarabot, J, and Behm, DG. Higher quadriceps roller massage forces do not amplify range-of-motion increases nor impair strength and jump performance. J Strength Cond Res 32(11): 3059–3069, 2018—Roller massage (RM) has been reported to increase range of motion (ROM) without subsequent performance decrements. However, the effects of different rolling forces have not been examined. The purpose of this study was to compare the effects of sham (RMsham), moderate (RMmod), and high (RMhigh) RM forces, calculated relative to the individuals' pain perception, on ROM, strength, and jump parameters. Sixteen healthy individuals (27 ± 4 years) participated in this study. The intervention involved three 60-second quadriceps RM bouts with RMlow (3.9/10 ± 0.64 rating of perceived pain [RPP]), RMmod (6.2/10 ± 0.64 RPP), and RMhigh (8.2/10 ± 0.44 RPP) pain conditions, respectively. A within-subject design was used to assess dependent variables (active and passive knee flexion ROM, single-leg drop jump [DJ] height, DJ contact time, DJ performance index, maximum voluntary isometric contraction [MVIC] force, and force produced in the first 200 milliseconds [F200] of the knee extensors and flexors). A 2-way repeated measures analysis of variance showed a main effect of testing time in active (p < 0.001, d = 2.54) and passive (p < 0.001, d = 3.22) ROM. Independent of the RM forces, active and passive ROM increased by 7.0% (p = 0.03, d = 2.25) and 15.4% (p < 0.001, d = 3.73) from premeasure to postmeasure, respectively. Drop jump and MVIC parameters were unaffected from pretest to posttest (p > 0.05, d = 0.33–0.84). Roller massage can be efficiently used to increase ROM without substantial pain and without subsequent performance impairments. KW - self-massage therapy KW - neuromuscular rolling KW - pressure KW - self-myofascial release Y1 - 2018 U6 - https://doi.org/10.1519/JSC.0000000000001906 SN - 1064-8011 SN - 1533-4287 VL - 32 IS - 11 SP - 3059 EP - 3069 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Chaabene, Helmi A1 - Negra, Yassine A1 - Capranica, Laura A1 - Prieske, Olaf A1 - Granacher, Urs T1 - A Needs Analysis of Karate Kumite With Recommendations for Performance Testing and Training JF - Strength and conditioning journal N2 - An effective training program needs to be customized to the specific demands of the redpective sport. Therefore, it is important to conduct a needs analysis to gain information on the unique characteristics of the sport. The objectives of thes review were (A) to conduct a systematic needs analysis of karate kumite and (B) to provide practical recommendations for sport-specific performance testing and training of karate kumite athletes. KW - sport profile KW - striking combat sports KW - strength KW - power KW - energetic systems KW - injury KW - assessment Y1 - 2019 U6 - https://doi.org/10.1519/SSC.0000000000000445 SN - 1524-1602 SN - 1533-4295 VL - 41 IS - 3 SP - 35 EP - 46 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Lesinski, Melanie A1 - Prieske, Olaf A1 - Helm, Norman A1 - Granacher, Urs T1 - Effects of Soccer Training on Anthropometry, Body Composition, and Physical Fitness during a Soccer Season in Female Elite Young Athletes: A Prospective Cohort Study JF - Frontiers in physiology N2 - The objectives of this study were to (i) describe soccer training (e.g., volume, types), anthropometry, body composition, and physical fitness and (0 compute associations between soccer training data and relative changes of anthropometry, body composition, and physical fitness during a soccer season in female elite young athletes. Seasonal training (i.e., day-to-day training volume/types) as well as variations in anthropometry (e.g., body height/mass), body composition (e.g., lean body/fat mass), and physical fitness (e.g., muscle strength/power, speed, balance) were collected from 17 female elite young soccer players (15.3 +/- 0.5 years) over the training periods (i.e., preparation, competition, transition) of a soccer season that resulted in the German championship title in under-17 female soccer. Training volume/types, anthropometrics, body composition, and physical fitness significantly varied over a soccer season. During the two preparation periods, higher volumes in resistance and endurance training were performed (2.00 <= d <= 18.15; p < 0.05), while higher sprint and tactical training volumes were applied during the two competition periods (2.22 <= d <= 11.18; p < 0.05). Body height and lean body mass increased over the season (2.50 <= d <= 3.39; p < 0.01). In terms of physical fitness, significant performance improvements were found over the soccer season in measures of balance, endurance, and sport-specific performance (2.52 <= d <= 3.95; p < 0.05). In contrast, no statistically significant changes were observed for measures of muscle power/endurance, speed, and change-of-direction speed. Of note, variables of muscle strength (i.e., leg extensors) significantly decreased (d = 2.39: p < 0.01) over the entire season. Our period specific sub analyses revealed significant performance improvements during the first round of the season for measures of muscle power/endurance, and balance (0.89 <= d <= 4.01; p < 0.05). Moreover, change-of-direction speed significantly declined after the first round of the season, i.e., transition period (d = 2.83; p < 0.01). Additionally, significant medium-to-large associations were observed between training and anthropometrics/body composition/physical fitness (-0.541 <= r <= 0.505). Soccer training and/or growth/maturation contributed to significant variations in anthropometry, body composition, and physical fitness outcomes throughout the different training periods over the course of a soccer season in female elite young soccer players. However, changes in components of fitness were inconsistent (e.g., power, speed, strength). Thus, training volume and/or types should be carefully considered in order to develop power-, speed- or strength-related fitness measures more efficiently throughout the soccer season. KW - adolescent athletes KW - annual training KW - periodization KW - training load KW - strength training Y1 - 2017 U6 - https://doi.org/10.3389/fphys.2017.01093 SN - 1664-042X VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Prieske, Olaf A1 - Chaabene, Helmi A1 - Gäbler, Martijn A1 - Herz, Michael A1 - Helm, Norman A1 - Markov, Adrian A1 - Granacher, Urs T1 - Seasonal changes in anthropometry, body composition, and physical fitness and the relationships with sporting success in young sub-elite judo athletes BT - an exploratory study JF - International journal of environmental research and public health : IJERPH N2 - This exploratory study aimed to monitor long-term seasonal developments in measures of anthropometry, body composition, and physical fitness in young judo athletes, and to compute associations between these measures and sporting success. Forty-four young judoka (20 females, 24 males) volunteered to participate. Tests for the assessment of anthropometry (e.g., body height/mass), body-composition (e.g., lean body mass), muscle strength (isometric handgrip strength), vertical jumping (e.g., countermovement-jump (CMJ) height), and dynamic balance (Y-balance test) were conducted at the beginning and end of a 10-month training season. Additionally, sporting success at the end of the season was recorded for each athlete. Analyses revealed significant time x sex interaction effects for lean-body-mass, isometric handgrip strength, and CMJ height (0.7 <= d <= 1.6). Post-hoc analyses showed larger gains for all measures in young males (1.9 <= d <= 6.0) compared with females (d = 2.4) across the season. Additionally, significant increases in body height and mass as well as Y-balance test scores were found from pre-to-post-test (1.2 <= d <= 4.3), irrespective of sex. Further, non-significant small-to-moderate-sized correlations were identified between changes in anthropometry/body composition/physical fitness and sporting success (p > 0.05; -0.34 <= rho <= 0.32). Regression analysis confirmed that no model significantly predicted sporting success. Ten months of judo training and/or growth/maturation contributed to significant changes in anthropometry, body composition, and physical fitness, particularly in young male judo athletes. KW - combat sports KW - periodization KW - somatic variables KW - training load KW - training KW - monitoring KW - young athletes Y1 - 2020 U6 - https://doi.org/10.3390/ijerph17197169 SN - 1660-4601 VL - 17 IS - 19 PB - MDPI AG CY - Basel ER - TY - JOUR A1 - Kasmi, Sofien A1 - Zouhal, Hassane A1 - Hammami, Raouf A1 - Clark, Cain Craig Truman A1 - Hackney, Anthony C. A1 - Hammami, Amri A1 - Chtara, Moktar A1 - Chortane, Sabri Gaied A1 - Ben Salah, Fatma Zohra A1 - Granacher, Urs A1 - Ben Ounis, Omar T1 - The Effects of Eccentric and Plyometric Training Programs and Their Combination on Stability and the Functional Performance in the Post-ACL-Surgical Rehabilitation Period of Elite Female Athletes JF - Frontiers in physiology N2 - Background: The standard method to treat physically active patients with anterior cruciate ligament (ACL) rupture is ligament reconstruction surgery. The rehabilitation training program is very important to improve functional performance in recreational athletes following ACL reconstruction. Objectives: The aims of this study were to compare the effects of three different training programs, eccentric training (ECC), plyometric training (PLYO), or combined eccentric and plyometric training (COMB), on dynamic balance (Y-BAL), the Lysholm Knee Scale (LKS), the return to sport index (RSI), and the leg symmetry index (LSI) for the single leg hop test for distance in elite female athletes after ACL surgery. Materials and Methods: Fourteen weeks after rehabilitation from surgery, 40 elite female athletes (20.3 ± 3.2 years), who had undergone an ACL reconstruction, participated in a short-term (6 weeks; two times a week) training study. All participants received the same rehabilitation protocol prior to the training study. Athletes were randomly assigned to three experimental groups, ECC (n = 10), PLYO (n = 10), and COMB (n = 10), and to a control group (CON: n = 10). Testing was conducted before and after the 6-week training programs and included the Y-BAL, LKS, and RSI. LSI was assessed after the 6-week training programs only. Results: Adherence rate was 100% across all groups and no training or test-related injuries were reported. No significant between-group baseline differences (pre-6-week training) were observed for any of the parameters. Significant group-by-time interactions were found for Y-BAL (p < 0.001, ES = 1.73), LKS (p < 0.001, ES = 0.76), and RSI (p < 0.001, ES = 1.39). Contrast analysis demonstrated that COMB yielded significantly greater improvements in Y-BAL, LKS, and RSI (all p < 0.001), in addition to significantly better performances in LSI (all p < 0.001), than CON, PLYO, and ECC, respectively. Conclusion: In conclusion, combined (eccentric/plyometric) training seems to represent the most effective training method as it exerts positive effects on both stability and functional performance in the post-ACL-surgical rehabilitation period of elite female athletes. KW - return-to-sport KW - anterior cruciate ligament KW - eccentric-plyometric KW - training KW - stability KW - functional performance Y1 - 2021 U6 - https://doi.org/10.3389/fphys.2021.688385 SN - 1664-042X VL - 12 SP - 1 EP - 11 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Delfan, Maryam A1 - Vahed, Alieh A1 - Bishop, David A1 - Juybari, Raheleh Amadeh A1 - Laher, Ismail A1 - Saeidi, Ayoub A1 - Granacher, Urs A1 - Zouhal, Hassane T1 - Effects of two workload-matched high-intensity interval training protocols on regulatory factors associated with mitochondrial biogenesis in the soleus muscle of diabetic rats JF - Frontiers in Physiology N2 - Aims: High intensity interval training (HIIT) improves mitochondrial characteristics. This study compared the impact of two workload-matched high intensity interval training (HIIT) protocols with different work:recovery ratios on regulatory factors related to mitochondrial biogenesis in the soleus muscle of diabetic rats. Materials and methods: Twenty-four Wistar rats were randomly divided into four equal-sized groups: non-diabetic control, diabetic control (DC), diabetic with long recovery exercise [4–5 × 2-min running at 80%–90% of the maximum speed reached with 2-min of recovery at 40% of the maximum speed reached (DHIIT1:1)], and diabetic with short recovery exercise (5–6 × 2-min running at 80%–90% of the maximum speed reached with 1-min of recovery at 30% of the maximum speed reached [DHIIT2:1]). Both HIIT protocols were completed five times/week for 4 weeks while maintaining equal running distances in each session. Results: Gene and protein expressions of PGC-1α, p53, and citrate synthase of the muscles increased significantly following DHIIT1:1 and DHIIT2:1 compared to DC (p ˂ 0.05). Most parameters, except for PGC-1α protein (p = 0.597), were significantly higher in DHIIT2:1 than in DHIIT1:1 (p ˂ 0.05). Both DHIIT groups showed significant increases in maximum speed with larger increases in DHIIT2:1 compared with DHIIT1:1. Conclusion: Our findings indicate that both HIIT protocols can potently up-regulate gene and protein expression of PGC-1α, p53, and CS. However, DHIIT2:1 has superior effects compared with DHIIT1:1 in improving mitochondrial adaptive responses in diabetic rats. KW - diabetes mellitus KW - muscle metabolism KW - time-efficient exercise KW - mitochondrial adaptation KW - exercise training Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.927969 SN - 1664-042X SP - 1 EP - 12 PB - Frontiers CY - Lausanne, Schweiz ER -