TY - JOUR A1 - Hartmann, Niklas K. A1 - Helbig, Kerstin A1 - Biernacka, Katarzyna A1 - Buchholz, Petra A1 - Dolzycka, Dominika A1 - Hartmann, Thomas A1 - Hiemenz, Bea A1 - Jacob, Boris A1 - Kuberek, Monika A1 - Weiß, Nadin A1 - Dreyer, Malte T1 - Lösungen und Leitfäden für das institutionelle Forschungsdatenmanagement JF - o-bib Das offene Bibliotheksjournal N2 - Hochschulen und deren Zentraleinrichtungen beschäftigen sich zunehmend mit dem Thema Forschungsdatenmanagement (FDM), um ihre Forschenden adäquat zu unterstützen. Nicht zuletzt aufgrund neuer Verlags- und Förderanforderungen wünschen sich Forschende Beratung und Orientierung, wie sie mit ihren Forschungsdaten umgehen sollen. Damit Hochschulen schnell und nachhaltig Lösungen zum institutionellen FDM etablieren können, haben fünf Berliner und Brandenburger Universitäten im gemeinsamen Verbundvorhaben FDMentor mit Förderung des Bundesministeriums für Bildung und Forschung (BMBF) entsprechende Leitfäden und Werkzeuge erarbeitet. Die innerhalb von zwei Jahren (2017–2019) entstandenen Ergebnisse in den Bereichen Strategieentwicklung, Forschungsdaten-Policy, rechtliche Aspekte und Kompetenzausbau finden über das Verbundprojekt hinaus ihre Anwendung. N2 - Universities and their central units are increasingly concerned with research data management (RDM) in order to adequately support their researchers. Not least because of new publishing and funding policies, researchers seek advice and guidance on how to handle their research data. To enable universities to quickly and sustainably establish institutional RDM solutions, five universities from Berlin and Brandenburg have developed guidelines and tools in the joint project FDMentor funded by the German Federal Ministry of Education and Research (BMBF). The results achieved over a period of two years (2017–2019) in the areas of strategy development, research data policy, legal aspects and competence enhancement are applied beyond the project partners. KW - Forschungsdatenmanagement KW - Strategieentwicklung KW - Forschungsdaten-Policy KW - Train-the-Trainer Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-472370 SN - 2363-9814 VL - 6 IS - 3 SP - 21 EP - 39 PB - VDB - Verein Deutscher Bibliothekarinnen und Bibliothekare e.V. CY - Erlangen ER - TY - JOUR A1 - Hartmann, Bianca A1 - Wai, Timothy A1 - Hu, Hao A1 - MacVicar, Thomas A1 - Musante, Luciana A1 - Fischer-Zirnsak, Björn A1 - Stenzel, Werner A1 - Gräf, Ralph A1 - van den Heuvel, Lambert A1 - Ropers, Hans-Hilger A1 - Wienker, Thomas F. A1 - Hübner, Christoph A1 - Langer, Thomas A1 - Kaindl, Angela M. T1 - Homozygous YME1L1 Mutation Causes Mitochondriopathy with Optic Atrophy and Mitochondrial Network Fragmentation JF - eLife N2 - Mitochondriopathies often present clinically as multisystemic disorders of primarily high-energy consuming organs. Assembly, turnover, and surveillance of mitochondrial proteins are essential for mitochondrial function and a key task of AAA family members of metalloproteases. We identified a homozygous mutation in the nuclear encoded mitochondrial escape 1-like 1 gene YME1L1, member of the AAA protease family, as a cause of a novel mitochondriopathy in a consanguineous pedigree of Saudi Arabian descent. The homozygous missense mutation, located in a highly conserved region in the mitochondrial pre-sequence, inhibits cleavage of YME1L1 by the mitochondrial processing peptidase, which culminates in the rapid degradation of YME1L1 precursor protein. Impaired YME1L1 function causes a proliferation defect and mitochondrial network fragmentation due to abnormal processing of OPA1. Our results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans. KW - YME1L1 KW - mitochondriopathy KW - intellectual disability KW - optic atrophy KW - OPA1 KW - mitochondrial fragmentation Y1 - 2016 U6 - https://doi.org/10.7554/eLife.16078 SN - 2050-084X VL - 5 SP - 1156 EP - 1165 PB - eLife Sciences Publications CY - Cambridge ER - TY - JOUR A1 - Hilgers, Leon A1 - Hartmann, Stefanie A1 - Hofreiter, Michael A1 - von Rintelen, Thomas T1 - Novel Genes, Ancient Genes, and Gene Co-Option Contributed o the Genetic Basis of the Radula, a Molluscan Innovation JF - Molecular biology and evolution N2 - The radula is the central foraging organ and apomorphy of the Mollusca. However, in contrast to other innovations, including the mollusk shell, genetic underpinnings of radula formation remain virtually unknown. Here, we present the first radula formative tissue transcriptome using the viviparous freshwater snail Tylomelania sarasinorum and compare it to foot tissue and the shell-building mantle of the same species. We combine differential expression, functional enrichment, and phylostratigraphic analyses to identify both specific and shared genetic underpinnings of the three tissues as well as their dominant functions and evolutionary origins. Gene expression of radula formative tissue is very distinct, but nevertheless more similar to mantle than to foot. Generally, the genetic bases of both radula and shell formation were shaped by novel orchestration of preexisting genes and continuous evolution of novel genes. A significantly increased proportion of radula-specific genes originated since the origin of stem-mollusks, indicating that novel genes were especially important for radula evolution. Genes with radula-specific expression in our study are frequently also expressed during the formation of other lophotrochozoan hard structures, like chaetae (hes1, arx), spicules (gbx), and shells of mollusks (gbx, heph) and brachiopods (heph), suggesting gene co-option for hard structure formation. Finally, a Lophotrochozoa-specific chitin synthase with a myosin motor domain (CS-MD), which is expressed during mollusk and brachiopod shell formation, had radula-specific expression in our study. CS-MD potentially facilitated the construction of complex chitinous structures and points at the potential of molecular novelties to promote the evolution of different morphological innovations. KW - chitin synthase KW - novelty KW - radula KW - RNAseq KW - shell KW - Tylomelania sarasinorum Y1 - 2018 U6 - https://doi.org/10.1093/molbev/msy052 SN - 0737-4038 SN - 1537-1719 VL - 35 IS - 7 SP - 1638 EP - 1652 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Voss, Henning A1 - Meyer, Jeannette A1 - Schwonbeck, Susanne A1 - Fritsche, Immo A1 - Hartmann, Bernhard A1 - Wegwarth, Odette A1 - Friedrich, Anke A1 - Buchheister-Knappe, Stefanie A1 - Marwan, Norbert A1 - Bandau, Anja A1 - Bullinger, Hans-Jörg A1 - Weith, Thomas T1 - Portal alumni T2 - Das Ehemaligen-Magazin der Universität Potsdam N2 - Liebe Leserin, lieber Leser, erforschen, was die Welt im Innersten zusammenhält- das ist für viele Studierende ein Traum. Doch welche Opfer muss man bringen, um ihn zu verwirklichen? Welche Bemfsperspektive hat der Bemf Forscher heute noch? Auch viele Absolventen der Universität Potsdam müssen sich diese Fragen beantworten. Zu welchen Antworten einige dabei gekommen sind und welche Probleme sie zu bewältigen haben, vom Spaß am Forschen und von Zukunftsängsten berichten sie in der Rubrik "Forscherkarrieren". Gelder für die Forschung fließen in Deutschland zu spärlich, verglichen mit anderen führenden Industrienationen. So sind die Bedingungen für Forscher hierzulande nicht die besten. Manchen jungen Wissenschaftler zieht es- mitunter notgedrungen- ins Ausland. Wie Deutschland dadurch seine ZukunftsHihigkeit riskiert, thematisiert der Präsident der Fraunhofer-Gesellschaft, Prof. Dr. Hans-Jörg Bullinger, in der Rubrik "wissenstransfer". Auch die Universität ist kein Garant für eine gesicherte Zukunft in der Forschung. Wer sechs Jahre nach der Promotion den Sprung zur Professur nicht geschafft hat, geht einer ungewissen Zukunft als Privatdozent entgegen. Seit einigen Jahren gibt es neben der Habilitation noch einen zweiten Weg zur Professur- die Juniorprofessur. Auch an der Universität Potsdam gibt es seit 2002 Juniorprofessoren, von denen die ersten jetzt evaluiert wurden. Näheres dazu finden Sie ebenfalls in der Rubrik "wissenstransfer". Wer noch nach einer Finanzierungsmöglichkeit für seine Promotion sucht, findet Tipps in der Rubrik "wegweiser". Die Redaktion wünscht Ihnen viel Vergnügen beim Lesen von Portal alumni und freut sich auf zahlreiche Leserbriefe. N2 - Dear readers, many students dream of researching the world's inner and outermost secrets. Still, what sacrifice must one bring in order to achieve this goa/, and what are the professional perspectives being offered to researchers today? Many University of Potsdom alumni have to find answers to these questions as weil. in the section "forscher/eben", a number of alumni discuss their answers, the problems that they have encountered along the way, the enJoyment that they have received through their research and their worries for the future. In Germany, the funding of research on part ofboth the state and the corporate world is sparsein comparison to other leading industrial countries, and the current opportunities for researchers are clearly not the best. in the section ,.wissenstransfer", the president of the Frauenhofer-Gesellschaft, Prof Dr. Hans-jörg Bullinger, discusses how Germany is losing its future potential in the process. Indeed, the university is no guarantee for a secure profossianal future in the research field. A few years ago, the Junior professorship was created as a second path to a Juli professorship, next to the traditional postdoctoral qualification (Habilitation). in 2002, the University of Potsdom began to establish Junior professorships. The first of these are currently being evaluated. More information on this process can be found in the section "wissenstransfer". In addition, suggestions and tips can be found in the section "wegweiser" for those who are seekingfunding opportunities for their dissertation work. T3 - Portal alumni : das Ehemaligen-Magazin der Universität Potsdam - 3/2005 Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-481608 VL - 2005 IS - 3 EP - 58 ER - TY - JOUR A1 - Hilgers, Leon A1 - Hartmann, Stefanie A1 - Pfaender, Jobst A1 - Lentge-Maass, Nora A1 - Marwoto, Ristiyanti M. A1 - von Rintelen, Thomas A1 - Hofreiter, Michael T1 - Evolutionary divergence and radula diversification in two ecomorphs from an adaptive radiation of freshwater snails JF - Genes N2 - (1) Background: Adaptive diversification of complex traits plays a pivotal role in the evolution of organismal diversity. In the freshwater snail genus Tylomelania, adaptive radiations were likely promoted by trophic specialization via diversification of their key foraging organ, the radula. (2) Methods: To investigate the molecular basis of radula diversification and its contribution to lineage divergence, we used tissue-specific transcriptomes of two sympatric Tylomelania sarasinorum ecomorphs. (3) Results: We show that ecomorphs are genetically divergent lineages with habitat-correlated abundances. Sequence divergence and the proportion of highly differentially expressed genes are significantly higher between radula transcriptomes compared to the mantle and foot. However, the same is not true when all differentially expressed genes or only non-synonymous SNPs are considered. Finally, putative homologs of some candidate genes for radula diversification (hh, arx, gbb) were also found to contribute to trophic specialization in cichlids and Darwin's finches. (4) Conclusions: Our results are in line with diversifying selection on the radula driving Tylomelania ecomorph divergence and indicate that some molecular pathways may be especially prone to adaptive diversification, even across phylogenetically distant animal groups. KW - speciation KW - adaptive radiation KW - molluscs KW - RNAseq KW - regulatory evolution KW - trophic specialization Y1 - 2022 U6 - https://doi.org/10.3390/genes13061029 SN - 2073-4425 VL - 13 IS - 6 PB - MDPI CY - Basel ER -