TY - JOUR A1 - Zhang, Yang A1 - Huang, Wentao A1 - Huang, Baochun A1 - van Hinsbergen, Douwe J. J. A1 - Yang, Tao A1 - Dupont-Nivet, Guillaume A1 - Guo, Zhaojie T1 - 53-43Ma Deformation of Eastern Tibet Revealed by Three Stages of Tectonic Rotation in the Gongjue Basin JF - Journal of geophysical research : Solid earth N2 - The Gongjue basin from the eastern Qiangtang terrane is located in the transition region where the regional structural lineation curves from east-west-oriented in Tibet to north-south-oriented in Yunnan. In this study, we sampled the red beds in the basin from the lower Gongjue to upper Ranmugou formations for the first time covering the entire stratigraphic profile. The stratigraphic ages are bracketed within 53-43Ma by new detrital zircon U-Pb ages constraining the maximum deposition age to 52.51.5Ma. Rock magnetic and petrographic studies indicate that detrital magnetite and hematite are the magnetic carriers. Positive reversals and fold tests demonstrate that the characteristic remanent magnetization has a primary origin. The Gongjue and Ranmugou formations yield mean characteristic remanent magnetization directions of D-s/I-s=31.0 degrees/21.3 degrees and D-s/I-s=15.9 degrees/22.0 degrees, respectively. The magnetic inclination of these characteristic remanent magnetizations is significantly shallowed compared to the expected inclination for the locality. However, the elongation/inclination correction method does not provide a meaningful correction, likely because of syn-depositional rotation. Rotations relative to the Eurasian apparent polar wander path occurred in three stages: Stage I, 33.33.4 degrees clockwise rotation during the deposition of the Gongjue and lower Ranmugou formations; Stage II, 26.93.7 degrees counterclockwise rotation during deposition of the lower and middle Ranmugou formation; and Stage III, 17.73.3 degrees clockwise rotation after 43Ma. The complex rotation history recorded in the basin is possibly linked to sinistral shear along the Qiangtang block during India indentation into Asia and the early stage of the extrusion of the northwestern Indochina blocks away from eastern Tibet. KW - eastern Qiangtang terrane KW - Gongjue basin KW - paleomagnetism KW - inclination shallowing KW - rotation Y1 - 2018 U6 - https://doi.org/10.1002/2018JB015443 SN - 2169-9313 SN - 2169-9356 VL - 123 IS - 5 SP - 3320 EP - 3338 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Yang, Guang A1 - Zheng, Wei A1 - Tao, Guoqing A1 - Wu, Libin A1 - Zhou, Qi-Feng A1 - Kochovski, Zdravko A1 - Ji, Tan A1 - Chen, Huaijun A1 - Li, Xiaopeng A1 - Lu, Yan A1 - Ding, Hong-ming A1 - Yang, Hai-Bo A1 - Chen, Guosong A1 - Jiang, Ming T1 - Diversiform and Transformable Glyco-Nanostructures Constructed from Amphiphilic Supramolecular Metallocarbohydrates through Hierarchical Self-Assembly: The Balance between Metallacycles and Saccharides JF - ACS nano N2 - During the past decade, self-assembly of saccharide-containing amphiphilic molecules toward bioinspired functional glycomaterials has attracted continuous attention due to their various applications in fundamental and practical areas. However, it still remains a great challenge to prepare hierarchical glycoassemblies with controllable and diversiform structures because of the complexity of saccharide structures and carbohydrate-carbohydrate interactions. Herein, through hierarchical self-assembly of modulated amphiphilic supramolecular metallocarbohydrates, we successfully prepared various well-defined glyco-nanostructures in aqueous solution, including vesicles, solid spheres, and opened vesicles depending on the molecular structures of metallocarbohydrates. More attractively, these glyco-nanostructures can further transform into other morphological structures in aqueous solutions such as worm-like micelles, tubules, and even tupanvirus-like vesicles (TVVs). It is worth mentioning that distinctive anisotropic structures including the opened vesicles (OVs) and TVVs were rarely reported in glycobased nano-objects. This intriguing diversity was mainly controlled by the subtle structural trade-off of the two major components of the amphiphiles, i.e., the saccharides and metallacycles. To further understand this precise structural control, molecular simulations provided deep physical insights on the morphology evolution and balancing of the contributions from saccharides and metallacycles. Moreover, the multivalency of glyco-nanostructures with different shapes and sizes was demonstrated by agglutination with a diversity of sugarbinding protein receptors such as the plant lectins Concanavalin A (ConA). This modular synthesis strategy provides access to systematic tuning of molecular structure and self-assembled architecture, which undoubtedly will broaden our horizons on the controllable fabrication of biomimetic glycomaterials such as biological membranes and supramolecular lectin inhibitors. KW - glycomaterials KW - diversiform structures KW - hierarchical self-assembly KW - metallocarbohydrates KW - anisotropic structures Y1 - 2019 U6 - https://doi.org/10.1021/acsnano.9b07134 SN - 1936-0851 SN - 1936-086X VL - 13 IS - 11 SP - 13474 EP - 13485 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Li, Xiaoxiao A1 - Yang, Wei A1 - Sun, Tao A1 - Gaedke, Ursula T1 - Quantitative food web structure and ecosystem functions in a warm-temperate seagrass bed JF - Marine biology : international journal on life in oceans and coastal waters N2 - Seagrass beds are important habitats in coastal areas but increasingly decline in area and quality, thus conservation measures are urgently needed. Quantitative food webs, describing the biomass distribution and energy fluxes among trophic groups, reveal structural and functional aspects of ecosystems. Their knowledge can improve ecological conservation. For the recently discovered large warm-temperate seagrass (Zostera japonica) habitat in China's Yellow River Delta wetland, we used delta C-13 and delta N-15 measurements and a Bayesian isotope mixing model to construct its food web diagram with quantitative estimations of consumer diet compositions, comprising detritus and 14 living trophic groups from primary producers to fish. We then estimated the quantitative food web fluxes based on biomass measurements and calculated corresponding ecosystem functions. Pelagic producers were significantly C-13-depleted compared to benthic sources. Consumers (except zooplankton) were increasingly C-13-depleted with increasing trophic positions even though the consumed benthic production surpassed the pelagic one. Bivalves dominated consumer biomasses and fluxes and were the first to connect the pelagic and benthic pathways, whereas zooplankton and gastropods were specialized on the two pathways, respectively. We found flat biomass and production pyramids indicating low trophic transfer efficiencies. Generally, the energetic structure of the quantitative food web was consistent with the stable isotope analysis, and the estimated net primary production and most estimated production to biomass ratios of the trophic groups fell within literature ranges. This study provides a systematical understanding of the quantitative trophic ecology of a seagrass bed and facilitates synergistic knowledge on management, conservation, and restoration. Y1 - 2021 U6 - https://doi.org/10.1007/s00227-021-03878-z SN - 0025-3162 SN - 1432-1793 VL - 168 IS - 5 PB - Springer CY - Berlin ; Heidelberg ER - TY - JOUR A1 - Bufe, Aaron A1 - Burbank, Douglas W. A1 - Liu, Langtao A1 - Bookhagen, Bodo A1 - Qin, Jintang A1 - Chen, Jie A1 - Li, Tao A1 - Jobe, Jessica Ann Thompson A1 - Yang, Huili T1 - Variations of Lateral Bedrock Erosion Rates Control Planation of Uplifting Folds in the Foreland of the Tian Shan, NW China JF - Journal of geophysical research : Earth surface N2 - Fluvial planation surfaces, such as straths, commonly serve as recorders of climatic and tectonic changes and are formed by the lateral erosion of rivers, a process that remains poorly understood. Here we present a study of kilometer-wide, fluvially eroded, low-relief surfaces on rapidly uplifting folds in the foreland of the southwestern Tian Shan. A combination of field work, digital elevation model analysis, and dating of fluvial deposits reveals that despite an arid climate and rapid average rock-uplift rates of 1-3mm/yr, rivers cut extensive (>1-2km wide) surfaces with typical height variations of <6m over periods of >2-6kyr. The extent of this beveling varies in space and time, such that different beveling episodes affect individual structures. Between times of planation, beveled surfaces are abandoned, incised, and deformed across the folds. In a challenge to models that link strath cutting and abandonment primarily to changes in river incision rates, we demonstrate that lateral erosion rates of antecedent streams crossing the folds have to vary by more than 1 order of magnitude to explain the creation of beveled platforms in the past and their incision at the present day. These variations do not appear to covary with climate variability and might be caused by relatively small (much less than an order of magnitude) changes in sediment or water fluxes. It remains uncertain in which settings variations in lateral bedrock erosion rates predominate over changes in vertical erosion rates. Therefore, when studying fluvial planation and strath terraces, variability of both lateral and vertical erosion rates should be considered. KW - strath terraces KW - lateral erosion KW - detachment folds KW - Quaternary geochronology Y1 - 2017 U6 - https://doi.org/10.1002/2016JF004099 SN - 2169-9003 SN - 2169-9011 VL - 122 SP - 2431 EP - 2467 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Thompson, Jessica A. A1 - Chen, Jie A1 - Yang, Huili A1 - Li, Tao A1 - Bookhagen, Bodo A1 - Burbank, Douglas T1 - Coarse- versus fine-grain quartz OSL and cosmogenic Be-10 dating of deformed fluvial terraces on the northeast Pamir margin, northwest China JF - Quaternary geochronology : the international research and review journal on advances in quaternary dating techniques N2 - Along the NE Pamir margin, flights of late Quaternary fluvial terraces span actively deforming fault-related folds. We present detailed results on two terraces dated using optically stimulated luminescence (OSL) and cosmogenic radionuclide Be-10 (CRN) techniques. Quartz OSL dating of two different grain sizes (4-11 mu m and 90-180 mu m) revealed the fine-grain quartz fraction may overestimate the terrace ages by up to a factor of ten. Two-mm, small-aliquot, coarse-grain quartz OSL ages, calculated using the minimum age model, yielded stratigraphically consistent ages within error and dated times of terrace deposition to similar to 9 and similar to 16 ka. We speculate that, in this arid environment, fine-grain samples can be transported and deposited in single, turbid, and (sometimes) night-time floods that prevent thorough bleaching and, thereby, can lead to relatively large residual OSL signals. In contrast, sand in the fluvial system is likely to have a much longer residence time during transport, thereby providing greater opportunities for thorough bleaching. CRN Be-10 depth profiles date the timing of terrace abandonment to similar to 8 and similar to 14 ka: ages that generally agree with the coarse-grain quartz OSL ages. Our new terrace age of similar to 13-14 ka is broadly consistent with other terraces in the region that indicate terrace deposition and subsequent abandonment occurred primarily during glacial-interglacial transitions, thereby suggesting a climatic control on the formation of these terraces on the margins of the Tarim Basin. Furthermore, tectonic shortening rates calculated from these deformed terraces range from similar to 1.2 to similar to 4.6 mm/a and, when combined with shortening rates from other structures in the region, illuminate the late Quaternary basinward migration of deformation to faults and folds along the Pamir-Tian Shan collisional interface. KW - Tectonic geomorphology KW - Deformation KW - Quaternary terraces KW - Pamir KW - Tian shan Y1 - 2018 U6 - https://doi.org/10.1016/j.quageo.2018.01.002 SN - 1871-1014 SN - 1878-0350 VL - 46 SP - 1 EP - 15 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Tao, Ting A1 - Su, Qiongli A1 - Xu, Simeng A1 - Deng, Jun A1 - Zhou, Sichun A1 - Zhuang, Yu A1 - Huang, Yanjun A1 - He, Caimei A1 - He, Shanping A1 - Peng, Mei A1 - Hocher, Berthold A1 - Yang, Xiaoping T1 - Down-regulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis JF - Journal of cellular physiology N2 - Fatty acid synthase (FASN) catalyzing the terminal steps in the de novo biogenesis of fatty acids is correlated with low survival and high disease recurrence in patients with bladder cancer. Pyruvate kinase M2 (PKM2) regulates the final step of glycolysis levels and provides a growth advantage to tumors. However, it is unclear whether the change of PKM2 has an effect on FASN and what is the mechanisms underlying. Here we describe a novel function of PKM2 in control of lipid metabolism by mediating transcriptional activation of FASN, showing the reduced expression of sterol regulatory element binding protein 1c (SREBP-1c). We first discovered that PKM2 physically interacts with the SREBP-1c using biochemical approaches, and downregulation of PKM2 reduced the expression of SREBP-1c by inactivating the AKT/mTOR signaling pathway, which in turn directly suppressed the transcription of major lipogenic genes FASN to reduce tumor growths. Furthermore, either PKM2 inhibitor-Shikonin or FASN inhibitor-TVB-3166 alone induced a strong antiproliferative and anticolony forming effect in bladder cancer cell line. The combination of both inhibitors exhibits a super synergistic effect on blocking the bladder cancer cells growth. It provides a new target and scientific basis for the treatment of bladder cancer. KW - bladder cancer cells KW - FASN KW - p-AKT KW - PKM2 KW - p-mTOR KW - SREBP-1c Y1 - 2018 U6 - https://doi.org/10.1002/jcp.27129 SN - 0021-9541 SN - 1097-4652 VL - 234 IS - 3 SP - 3088 EP - 3104 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Xu, Yaolin A1 - Dong, Kang A1 - Jie, Yulin A1 - Adelhelm, Philipp A1 - Chen, Yawei A1 - Xu, Liang A1 - Yu, Peiping A1 - Kim, Junghwa A1 - Kochovski, Zdravko A1 - Yu, Zhilong A1 - Li, Wanxia A1 - LeBeau, James A1 - Shao-Horn, Yang A1 - Cao, Ruiguo A1 - Jiao, Shuhong A1 - Cheng, Tao A1 - Manke, Ingo A1 - Lu, Yan T1 - Promoting mechanistic understanding of lithium deposition and solid-electrolyte interphase (SEI) formation using advanced characterization and simulation methods: recent progress, limitations, and future perspectives JF - Avanced energy materials N2 - In recent years, due to its great promise in boosting the energy density of lithium batteries for future energy storage, research on the Li metal anode, as an alternative to the graphite anode in Li-ion batteries, has gained significant momentum. However, the practical use of Li metal anodes has been plagued by unstable Li (re)deposition and poor cyclability. Although tremendous efforts have been devoted to the stabilization of Li metal anodes, the mechanisms of electrochemical (re-)deposition/dissolution of Li and solid-electrolyte-interphase (SEI) formation remain elusive. This article highlights the recent mechanistic understandings and observations of Li deposition/dissolution and SEI formation achieved from advanced characterization techniques and simulation methods, and discusses major limitations and open questions in these processes. In particular, the authors provide their perspectives on advanced and emerging/potential methods for obtaining new insights into these questions. In addition, they give an outlook into cutting-edge interdisciplinary research topics for Li metal anodes. It pushes beyond the current knowledge and is expected to accelerate development toward a more in-depth and comprehensive understanding, in order to guide future research on Li metal anodes toward practical application. KW - advanced characterization KW - Li deposition KW - Li dissolution KW - Li metal KW - anodes KW - mechanistic understanding KW - solid-electrolyte-interphase KW - theoretical simulation Y1 - 2022 U6 - https://doi.org/10.1002/aenm.202200398 SN - 1614-6832 SN - 1614-6840 VL - 12 IS - 19 PB - Wiley CY - Weinheim ER -