TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - GEN
A1  - Anderson, Christopher J.
A1  - Bahnik, Stepan
A1  - Barnett-Cowan, Michael
A1  - Bosco, Frank A.
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cordes, Andreas
A1  - Cremata, Edward J.
A1  - Della Penna, Nicolas
A1  - Estel, Vivien
A1  - Fedor, Anna
A1  - Fitneva, Stanka A.
A1  - Frank, Michael C.
A1  - Grange, James A.
A1  - Hartshorne, Joshua K.
A1  - Hasselman, Fred
A1  - Henninger, Felix
A1  - van der Hulst, Marije
A1  - Jonas, Kai J.
A1  - Lai, Calvin K.
A1  - Levitan, Carmel A.
A1  - Miller, Jeremy K.
A1  - Moore, Katherine S.
A1  - Meixner, Johannes M.
A1  - Munafo, Marcus R.
A1  - Neijenhuijs, Koen I.
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Ricker, Ashley A.
A1  - Schmidt, Kathleen
A1  - Spies, Jeffrey R.
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - van Aert, Robbie C. M.
A1  - van Assen, Marcel A. L. M.
A1  - Vanpaemel, Wolf
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Zuni, Kellylynn
T1  - Response to Comment on "Estimating the reproducibility of psychological science"
T2  - Science
N2  - Gilbert et al. conclude that evidence from the Open Science Collaboration’s Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted.
Y1  - 2016
U6  - https://doi.org/10.1126/science.aad9163
SN  - 0036-8075
SN  - 1095-9203
VL  - 351
SP  - 1162
EP  - 1165
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Ghosh, H.
A1  - DePoy, D. L.
A1  - Gal-Yam, A.
A1  - Gaudi, B. S.
A1  - Gould, A.
A1  - Han, C.
A1  - Lipkin, Y.
A1  - Maoz, D.
A1  - Ofek, E. O.
A1  - Park, B. G.
A1  - Pogge, R. W.
A1  - Salim, S.
A1  - Abe, Fumio
A1  - Bennett, David P.
A1  - Bond, I. A.
A1  - Eguchi, S.
A1  - Furuta, Y.
A1  - Hearnshaw, John B.
A1  - Kamiya, K.
A1  - Kilmartin, Pam M.
A1  - Kurata, Y.
A1  - Masuda, Kimiaki
A1  - Matsubara, Yutaka
A1  - Muraki, Y.
A1  - Noda, S.
A1  - Okajima, K.
A1  - Rattenbury, N. J.
A1  - Sako, T.
A1  - Sekiguchi, T.
A1  - Sullivan, D. J.
A1  - Sumi, T.
A1  - Tristram, P. J.
A1  - Yanagisawa, T.
A1  - Yock, P. C. M.
A1  - Udalski, A.
A1  - Soszynski, I.
A1  - Wyrzykowski, X.
A1  - Kubiak, Marcin
A1  - Szymanski, M. K.
A1  - Pietrzynski, G.
A1  - Szewczyk, O.
A1  - Zebru, 
T1  - Potential direct single-star mass measurement
N2  - We analyze the light curve of the microlensing event OGLE-2003-BLG-175/MOA-2003-BLG-45 and show that it has two properties that, when combined with future high-resolution astrometry, could lead to a direct, accurate measurement of the lens mass. First, the light curve shows clear signs of distortion due to the Earth's accelerated motion, which yields a measurement of the projected Einstein radius (r) over tilde (E). Second, from precise astrometric measurements, we show that the blended light in the event is coincident with the microlensed source to within about 15 mas. This argues strongly that this blended light is the lens and hence opens the possibility of directly measuring the lens- source relative proper motion mu(rel) and so the mass M=(c(2)/4G)mu(rel)t(E)(r) over tilde (E), where t(E) is the measured Einstein timescale. While the light-curve-based measurement of (r) over tildeE is, by itself, severely degenerate, we show that this degeneracy can be completely resolved by measuring the direction of proper motion mu(rel)
Y1  - 2004
SN  - 0004-637X
ER  - 
TY  - JOUR
A1  - Tang, Alan T.
A1  - Sullivan, Katie Rose
A1  - Hong, Courtney C.
A1  - Goddard, Lauren M.
A1  - Mahadevan, Aparna
A1  - Ren, Aileen
A1  - Pardo, Heidy
A1  - Peiper, Amy
A1  - Griffin, Erin
A1  - Tanes, Ceylan
A1  - Mattei, Lisa M.
A1  - Yang, Jisheng
A1  - Li, Li
A1  - Mericko-Ishizuka, Patricia
A1  - Shen, Le
A1  - Hobson, Nicholas
A1  - Girard, Romuald
A1  - Lightle, Rhonda
A1  - Moore, Thomas
A1  - Shenkar, Robert
A1  - Polster, Sean P.
A1  - Roedel, Claudia Jasmin
A1  - Li, Ning
A1  - Zhu, Qin
A1  - Whitehead, Kevin J.
A1  - Zheng, Xiangjian
A1  - Akers, Amy
A1  - Morrison, Leslie
A1  - Kim, Helen
A1  - Bittinger, Kyle
A1  - Lengner, Christopher J.
A1  - Schwaninger, Markus
A1  - Velcich, Anna
A1  - Augenlicht, Leonard
A1  - Abdelilah-Seyfried, Salim
A1  - Min, Wang
A1  - Marchuk, Douglas A.
A1  - Awad, Issam A.
A1  - Kahn, Mark L.
T1  - Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
JF  - Science Translational Medicine
N2  - Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial CCM is caused by genetic mutations in KRIT1, CCM2, or PDCD10. Disease onset is earlier and more severe in individuals with PDCD10 mutations. Recent studies have shown that lesions arise from excess mitogen-activated protein kinase kinase kinase 3 (MEKK3) signaling downstream of Toll-like receptor 4 (TLR4) stimulation by lipopolysaccharide derived from the gut microbiome. These findings suggest a gut-brain CCM disease axis but fail to define it or explain the poor prognosis of patients with PDCD10 mutations. Here, we demonstrate that the gut barrier is a primary determinant of CCM disease course, independent of microbiome configuration, that explains the increased severity of CCM disease associated with PDCD10 deficiency. Chemical disruption of the gut barrier with dextran sulfate sodium augments CCM formation in a mouse model, as does genetic loss of Pdcd10, but not Krit1, in gut epithelial cells. Loss of gut epithelial Pdcd10 results in disruption of the colonic mucosal barrier. Accordingly, loss of Mucin-2 or exposure to dietary emulsifiers that reduce the mucus barrier increases CCM burden analogous to loss of Pdcd10 in the gut epithelium. Last, we show that treatment with dexamethasone potently inhibits CCM formation in mice because of the combined effect of action at both brain endothelial cells and gut epithelial cells. These studies define a gut-brain disease axis in an experimental model of CCM in which a single gene is required for two critical components: gut epithelial function and brain endothelial signaling.
Y1  - 2019
U6  - https://doi.org/10.1126/scitranslmed.aaw3521
SN  - 1946-6234
SN  - 1946-6242
VL  - 11
IS  - 520
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Lissner, Tabea Katharina
A1  - Sullivan, C. A.
A1  - Reusser, D. E.
A1  - Kropp, Jürgen
T1  - Determining regional limits and sectoral constraints for water use
JF  - Hydrology and earth system sciences : HESS
N2  - Water is an essential input to the majority of human activities. Often, access to sufficient water resources is limited by quality and infrastructure aspects, rather than by resource availability alone, and each activity has different requirements regarding the nature of these aspects. This paper develops an integrated approach to assess the adequacy of water resources for the three major water users: the domestic, agricultural and industrial sectors. Additionally, we include environmental water requirements. We first outline the main determinants of water adequacy for each sector. Subsequently, we present an integrated approach using fuzzy logic, which allows assessing sector-specific as well as overall water adequacy. We implement the approach in two case study settings to exemplify the main features of the approach. Using results from two climate models and two forcing RCPs (representative concentration pathways), as well as population projections, we further assess the impacts of climate change in combination with population growth on the adequacy of water resources. The results provide an important step forward in determining the most relevant factors, impeding adequate access to water, which remains an important challenge in many regions of the world. The methodology allows one to directly identify the factors that are most decisive in determining the adequacy of water in each region, pointing towards the most efficient intervention points to improve conditions. Our findings underline the fact that, in addition to water volumes, water quality is a limitation for all sectors and, especially for the environmental sector, high levels of pollution are a threat to water adequacy.
Y1  - 2014
U6  - https://doi.org/10.5194/hess-18-4039-2014
SN  - 1027-5606
SN  - 1607-7938
VL  - 18
IS  - 10
SP  - 4039
EP  - 4052
PB  - Copernicus
CY  - Göttingen
ER  -