TY  - JOUR
A1  - Abeysekara, A. U.
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Brose, Robert
A1  - Buchovecky, M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Chromey, A. J.
A1  - Connolly, M. P.
A1  - Cui, Wei
A1  - Daniel, M. K.
A1  - Falcone, A.
A1  - Feng, Qi
A1  - Finley, John P.
A1  - Fortson, L.
A1  - Furniss, Amy
A1  - Huetten, M.
A1  - Hanna, David
A1  - Hervet, O.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Humensky, T. B.
A1  - Johnson, Caitlin A.
A1  - Kaaret, Philip
A1  - Kar, P.
A1  - Kertzman, M.
A1  - Kieda, David
A1  - Krause, M.
A1  - Krennrich, F.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Mukherjee, Reshmi
A1  - Ong, R. A.
A1  - Otte, Adam Nepomuk
A1  - Park, Nahee
A1  - Petrashyk, A.
A1  - Pohl, Martin
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, Gregory T.
A1  - Roache, E.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, Marcos
A1  - Sembroski, G. H.
A1  - Shahinyan, Karlen
A1  - Sushch, I.
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Williamson, T. J.
A1  - Zitzer, B.
A1  - Abdollahi, S.
A1  - Ajello, Marco
A1  - Baldini, Luca
A1  - Barbiellini, G.
A1  - Bastieri, Denis
A1  - Bellazzini, Ronaldo
A1  - Berenji, B.
A1  - Bissaldi, Elisabetta
A1  - Blandford, R. D.
A1  - Bonino, R.
A1  - Bottacini, E.
A1  - Brandt, Terri J.
A1  - Bruel, P.
A1  - Buehler, R.
A1  - Cameron, R. A.
A1  - Caputo, R.
A1  - Caraveo, P. A.
A1  - Castro, D.
A1  - Cavazzuti, E.
A1  - Charles, Eric
A1  - Chiaro, G.
A1  - Ciprini, S.
A1  - Cohen-Tanugi, Johann
A1  - Costantin, D.
A1  - Cutini, S.
A1  - de Palma, F.
A1  - Di Lalla, N.
A1  - Di Mauro, M.
A1  - Di Venere, L.
A1  - Dominguez, A.
A1  - Favuzzi, C.
A1  - Fegan, S. J.
A1  - Franckowiak, Anna
A1  - Fukazawa, Yasushi
A1  - Funk, Stefan
A1  - Fusco, Piergiorgio
A1  - Gargano, Fabio
A1  - Gasparrini, Dario
A1  - Giglietto, Nicola
A1  - Giordano, F.
A1  - Giroletti, Marcello
A1  - Green, D.
A1  - Grenier, I. A.
A1  - Guillemot, L.
A1  - Guiriec, Sylvain
A1  - Hays, Elizabeth
A1  - Hewitt, John W.
A1  - Horan, D.
A1  - Johannesson, G.
A1  - Kensei, S.
A1  - Kuss, M.
A1  - Larsson, Stefan
A1  - Latronico, L.
A1  - Lemoine-Goumard, Marianne
A1  - Li, J.
A1  - Longo, Francesco
A1  - Loparco, Francesco
A1  - Lovellette, M. N.
A1  - Lubrano, Pasquale
A1  - Magill, Jeffrey D.
A1  - Maldera, Simone
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J. E.
A1  - Michelson, P. F.
A1  - Mitthumsiri, W.
A1  - Mizuno, Tsunefumi
A1  - Monzani, Maria Elena
A1  - Morselli, Aldo
A1  - Moskalenko, Igor V.
A1  - Negro, M.
A1  - Nuss, E.
A1  - Ojha, R.
A1  - Omodei, Nicola
A1  - Orienti, M.
A1  - Orlando, E.
A1  - Palatiello, M.
A1  - Paliya, Vaidehi S.
A1  - Paneque, D.
A1  - Perkins, Jeremy S.
A1  - Persic, M.
A1  - Pesce-Rollins, Melissa
A1  - Petrosian, Vahe'
A1  - Piron, F.
A1  - Porter, Troy A.
A1  - Principe, G.
A1  - Raino, S.
A1  - Rando, Riccardo
A1  - Rani, B.
A1  - Razzano, Massimilano
A1  - Razzaque, Soebur
A1  - Reimer, A.
A1  - Reimer, Olaf
A1  - Reposeur, T.
A1  - Sgro, C.
A1  - Siskind, E. J.
A1  - Spandre, Gloria
A1  - Spinelli, P.
A1  - Suson, D. J.
A1  - Tajima, Hiroyasu
A1  - Thayer, J. B.
A1  - Thompson, David J.
A1  - Torres, Diego F.
A1  - Tosti, Gino
A1  - Troja, Eleonora
A1  - Valverde, J.
A1  - Vianello, Giacomo
A1  - Vogel, M.
A1  - Wood, K.
A1  - Yassine, M.
A1  - Alfaro, R.
A1  - Alvarez, C.
A1  - Alvarez, J. D.
A1  - Arceo, R.
A1  - Arteaga-Velazquez, J. C.
A1  - Rojas, D. Avila
A1  - Ayala Solares, H. A.
A1  - Becerril, A.
A1  - Belmont-Moreno, E.
A1  - BenZvi, S. Y.
A1  - Bernal, A.
A1  - Braun, J.
A1  - Brisbois, C.
A1  - Caballero-Mora, K. S.
A1  - Capistran, T.
A1  - Carraminana, A.
A1  - Casanova, Sabrina
A1  - Castillo, M.
A1  - Cotti, U.
A1  - Cotzomi, J.
A1  - Coutino de Leon, S.
A1  - De Leon, C.
A1  - De la Fuente, E.
A1  - Dichiara, S.
A1  - Dingus, B. L.
A1  - DuVernois, M. A.
A1  - Diaz-Velez, J. C.
A1  - Engel, K.
A1  - Enriquez-Rivera, O.
A1  - Fiorino, D. W.
A1  - Fleischhack, H.
A1  - Fraija, N.
A1  - Garcia-Gonzalez, J. A.
A1  - Garfias, F.
A1  - Gonzalez Munoz, A.
A1  - Gonzalez, M. M.
A1  - Goodman, J. A.
A1  - Hampel-Arias, Z.
A1  - Harding, J. P.
A1  - Hernandez, S.
A1  - Hernandez-Almada, A.
A1  - Hona, B.
A1  - Hueyotl-Zahuantitla, F.
A1  - Hui, C. M.
A1  - Huntemeyer, P.
A1  - Iriarte, A.
A1  - Jardin-Blicq, A.
A1  - Joshi, V.
A1  - Kaufmann, S.
A1  - Lara, A.
A1  - Lauer, R. J.
A1  - Lee, W. H.
A1  - Lennarz, D.
A1  - Leon Vargas, H.
A1  - Linnemann, J. T.
A1  - Longinotti, A. L.
A1  - Luis-Raya, G.
A1  - Luna-Garcia, R.
A1  - Lopez-Coto, R.
A1  - Malone, K.
A1  - Marinelli, S. S.
A1  - Martinez, O.
A1  - Martinez-Castellanos, I.
A1  - Martinez-Castro, J.
A1  - Martinez-Huerta, H.
A1  - Matthews, J. A.
A1  - Miranda-Romagnoli, P.
A1  - Moreno, E.
A1  - Mostafa, M.
A1  - Nayerhoda, A.
A1  - Nellen, L.
A1  - Newbold, M.
A1  - Nisa, M. U.
A1  - Noriega-Papaqui, R.
A1  - Pelayo, R.
A1  - Pretz, J.
A1  - Perez-Perez, E. G.
A1  - Ren, Z.
A1  - Rho, C. D.
A1  - Riviere, C.
A1  - Rosa-Gonzalez, D.
A1  - Rosenberg, M.
A1  - Ruiz-Velasco, E.
A1  - Salazar, H.
A1  - Greus, F. Salesa
A1  - Sandoval, A.
A1  - Schneider, M.
A1  - Arroyo, M. Seglar
A1  - Sinnis, G.
A1  - Smith, A. J.
A1  - Springer, R. W.
A1  - Surajbali, P.
A1  - Taboada, Ignacio
A1  - Tibolla, O.
A1  - Tollefson, K.
A1  - Torres, I.
A1  - Ukwatta, Tilan N.
A1  - Villasenor, L.
A1  - Weisgarber, T.
A1  - Westerhoff, Stefan
A1  - Wisher, I. G.
A1  - Wood, J.
A1  - Yapici, Tolga
A1  - Yodh, G.
A1  - Zepeda, A.
A1  - Zhou, H.
T1  - VERITAS and Fermi-LAT Observations of TeV Gamma-Ray Sources Discovered by HAWC in the 2HWC Catalog
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - The High Altitude Water Cherenkov (HAWC) collaboration recently published their 2HWC catalog, listing 39 very high energy (VHE; >100 GeV) gamma-ray sources based on 507 days of observation. Among these, 19 sources are not associated with previously known teraelectronvolt (TeV) gamma-ray sources. We have studied 14 of these sources without known counterparts with VERITAS and Fermi-LAT. VERITAS detected weak gamma-ray emission in the 1 TeV-30 TeV band in the region of DA 495, a pulsar wind nebula coinciding with 2HWC J1953+294, confirming the discovery of the source by HAWC. We did not find any counterpart for the selected 14 new HAWC sources from our analysis of Fermi-LAT data for energies higher than 10 GeV. During the search, we detected gigaelectronvolt (GeV) gamma-ray emission coincident with a known TeV pulsar wind nebula, SNR G54.1+0.3 (VER J1930+188), and a 2HWC source, 2HWC J1930+188. The fluxes for isolated, steady sources in the 2HWC catalog are generally in good agreement with those measured by imaging atmospheric Cherenkov telescopes. However, the VERITAS fluxes for SNR G54.1+0.3, DA 495, and TeV J2032+4130 are lower than those measured by HAWC, and several new HAWC sources are not detected by VERITAS. This is likely due to a change in spectral shape, source extension, or the influence of diffuse emission in the source region.
KW  - gamma rays: general
Y1  - 2018
U6  - https://doi.org/10.3847/1538-4357/aade4e
SN  - 0004-637X
SN  - 1538-4357
VL  - 866
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Gaudry, Michael J.
A1  - Jastroch, Martin
A1  - Treberg, Jason R.
A1  - Hofreiter, Michael
A1  - Paijmans, Johanna L. A.
A1  - Starrett, James
A1  - Wales, Nathan
A1  - Signore, Anthony V.
A1  - Springer, Mark S.
A1  - Campbell, Kevin L.
T1  - Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades
JF  - Science Advances
Y1  - 2017
U6  - https://doi.org/10.1126/sciadv.1602878
SN  - 2375-2548
VL  - 3
SP  - S337
EP  - S337
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Springer, Mark S.
A1  - Signore, Anthony V.
A1  - Paijmans, Johanna L. A.
A1  - Velez-Juarbe, Jorge
A1  - Domning, Daryl P.
A1  - Bauer, Cameron E.
A1  - He, Kai
A1  - Crerar, Lorelei
A1  - Campos, Paula F.
A1  - Murphy, William J.
A1  - Meredith, Robert W.
A1  - Gatesy, John
A1  - Willerslev, Eske
A1  - MacPhee, Ross D. E.
A1  - Hofreiter, Michael
A1  - Campbell, Kevin L.
T1  - Interordinal gene capture, the phylogenetic position of Steller's sea cow based on molecular and morphological data, and the macroevolutionary history of Sirenia
JF  - Molecular phylogenetics and evolution
N2  - The recently extinct (ca. 1768) Steller's sea cow (Hydrodamalis gigas) was a large, edentulous North Pacific sirenian. The phylogenetic affinities of this taxon to other members of this clade, living and extinct, are uncertain based on previous morphological and molecular studies. We employed hybridization capture methods and second generation sequencing technology to obtain >30 kb of exon sequences from 26 nuclear genes for both H. gigas and Dugong dugon. We also obtained complete coding sequences for the tooth-related enamelin (ENAM) gene. Hybridization probes designed using dugong and manatee sequences were both highly effective in retrieving sequences from H. gigas (mean = 98.8% coverage), as were more divergent probes for regions of ENAM (99.0% coverage) that were designed exclusively from a proboscidean (African elephant) and a hyracoid (Cape hyrax). New sequences were combined with available sequences for representatives of all other afrotherian orders. We also expanded a previously published morphological matrix for living and fossil Sirenia by adding both new taxa and nine new postcranial characters. Maximum likelihood and parsimony analyses of the molecular data provide robust support for an association of H. gigas and D. dugon to the exclusion of living trichechids (manatees). Parsimony analyses of the morphological data also support the inclusion of H. gigas in Dugongidae with D. dugon and fossil dugongids. Timetree analyses based on calibration density approaches with hard- and soft-bounded constraints suggest that H. gigas and D. dugon diverged in the Oligocene and that crown sirenians last shared a common ancestor in the Eocene. The coding sequence for the ENAM gene in H. gigas does not contain frameshift mutations or stop codons, but there is a transversion mutation (AG to CG) in the acceptor splice site of intron 2. This disruption in the edentulous Steller's sea cow is consistent with previous studies that have documented inactivating mutations in tooth-specific loci of a variety of edentulous and enamelless vertebrates including birds, turtles, aardvarks, pangolins, xenarthrans, and baleen whales. Further, branch-site dN/dS analyses provide evidence for positive selection in ENAM on the stem dugongid branch where extensive tooth reduction occurred, followed by neutral evolution on the Hydrodamalis branch. Finally, we present a synthetic evolutionary tree for living and fossil sirenians showing several key innovations in the history of this clade including character state changes that parallel those that occurred in the evolutionary history of cetaceans. (C) 2015 Elsevier Inc. All rights reserved.
Y1  - 2015
U6  - https://doi.org/10.1016/j.ympev.2015.05.022
SN  - 1055-7903
SN  - 1095-9513
VL  - 91
SP  - 178
EP  - 193
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - Ruhmann, Ralf
A1  - Thiele, T.
A1  - Wolff, Dietmar
A1  - Prescher, Dietrich
A1  - Springer, J.
T1  - Liquid crystalline side group polymers with azo-chromophores and fluorinated tails of varying length
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Wolff, Dietmar
A1  - Ruhmann, Ralf
A1  - Thiele, T.
A1  - Prescher, Dietrich
A1  - Springer, J.
T1  - Liquid-crystalline side group polymers with fluorine-containing azo-chromophores
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Lim, Sze Chern
A1  - Friemel, Martin
A1  - Marum, Justine E.
A1  - Tucker, Elena J.
A1  - Bruno, Damien L.
A1  - Riley, Lisa G.
A1  - Christodoulou, John
A1  - Kirk, Edwin P.
A1  - Boneh, Avihu
A1  - DeGennaro, Christine M.
A1  - Springer, Michael
A1  - Mootha, Vamsi K.
A1  - Rouault, Tracey A.
A1  - Leimkühler, Silke
A1  - Thorburn, David R.
A1  - Compton, Alison G.
T1  - Mutations in LYRM4, encoding ironsulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes
JF  - Human molecular genetics
N2  - Ironsulfur clusters (ISCs) are important prosthetic groups that define the functions of many proteins. Proteins with ISCs (called ironsulfur or FeS proteins) are present in mitochondria, the cytosol, the endoplasmic reticulum and the nucleus. They participate in various biological pathways including oxidative phosphorylation (OXPHOS), the citric acid cycle, iron homeostasis, heme biosynthesis and DNA repair. Here, we report a homozygous mutation in LYRM4 in two patients with combined OXPHOS deficiency. LYRM4 encodes the ISD11 protein, which forms a complex with, and stabilizes, the sulfur donor NFS1. The homozygous mutation (c.203GT, p.R68L) was identified via massively parallel sequencing of 1000 mitochondrial genes (MitoExome sequencing) in a patient with deficiency of complexes I, II and III in muscle and liver. These three complexes contain ISCs. Sanger sequencing identified the same mutation in his similarly affected cousin, who had a more severe phenotype and died while a neonate. Complex IV was also deficient in her skeletal muscle. Several other FeS proteins were also affected in both patients, including the aconitases and ferrochelatase. Mutant ISD11 only partially complemented for an ISD11 deletion in yeast. Our in vitro studies showed that the l-cysteine desulfurase activity of NFS1 was barely present when co-expressed with mutant ISD11. Our findings are consistent with a defect in the early step of ISC assembly affecting a broad variety of FeS proteins. The differences in biochemical and clinical features between the two patients may relate to limited availability of cysteine in the newborn period and suggest a potential approach to therapy.
Y1  - 2013
U6  - https://doi.org/10.1093/hmg/ddt295
SN  - 0964-6906
SN  - 1460-2083
VL  - 22
IS  - 22
SP  - 4460
EP  - 4473
PB  - Oxford Univ. Press
CY  - Oxford
ER  -