TY  - GEN
A1  - Xie, Chao
A1  - Jia, Tianye
A1  - Rolls, Edmund T.
A1  - Robbins, Trevor W.
A1  - Sahakian, Barbara J.
A1  - Zhang, Jie
A1  - Liu, Zhaowen
A1  - Cheng, Wei
A1  - Luo, Qiang
A1  - Zac Lo, Chun-Yi
A1  - Schumann, Gunter
A1  - Feng, Jianfeng
A1  - Wang, He
A1  - Banaschewski, Tobias
A1  - Barker, Gareth J.
A1  - Bokde, Arun L.W.
A1  - Büchel, Christian
A1  - Quinlan, Erin Burke
A1  - Desrivières, Sylvane
A1  - Flor, Herta
A1  - Grigis, Antoine
A1  - Garavan, Hugh
A1  - Gowland, Penny
A1  - Heinz, Andreas
A1  - Hohmann, Sarah
A1  - Ittermann, Bernd
A1  - Martinot, Jean-Luc
A1  - Paillère Martinot, Marie-Laure
A1  - Nees, Frauke
A1  - Papadopoulos Orfanos, Dimitri
A1  - Paus, Tomáš
A1  - Poustka, Luise
A1  - Fröhner, Juliane H.
A1  - Smolka, Michael N.
A1  - Walter, Henrik
A1  - Whelan, Robert
T1  - Reward versus nonreward sensitivity of the medial versus lateral orbitofrontal cortex relates to the severity of depressive symptoms
T2  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms.

METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14.

RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003).

CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 860 
KW  - adolescents
KW  - depression
KW  - monetary incentive delay task
KW  - nonreward sensitivity
KW  - orbitofrontal cortex
KW  - reward anticipation
KW  - reward sensitivity
KW  - ventral striatum
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-557882
SN  - 1866-8364
IS  - 3
ER  -