TY - GEN A1 - Kayhan Wagner, Ezgi A1 - Meyer, Marlene A1 - O’Reilly, J.X. A1 - Hunnius, Sabine A1 - Bekkering, Harold T1 - Nine-month-old infants update their predictive models of a changing environment T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Humans generate internal models of their environment to predict events in the world. As the environments change, our brains adjust to these changes by updating their internal models. Here, we investigated whether and how 9-month-old infants differentially update their models to represent a dynamic environment. Infants observed a predictable sequence of stimuli, which were interrupted by two types of cues. Following the update cue, the pattern was altered, thus, infants were expected to update their predictions for the upcoming stimuli. Because the pattern remained the same after the no-update cue, no subsequent updating was required. Infants showed an amplified negative central (Nc) response when the predictable sequence was interrupted. Late components such as the PSW were also evoked in response to unexpected stimuli; however, we found no evidence for a differential response to the informational value of surprising cues at later stages of processing. Infants rather learned that surprising cues always signal a change in the environment that requires updating. Interestingly, infants responded with an amplified neural response to the absence of an expected change, suggesting a top-down modulation of early sensory processing in infants. Our findings corroborate emerging evidence showing that infants build predictive models early in life. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 577 KW - Internal models KW - Predictive models KW - Predictive processing KW - Development KW - Event-Related potentials Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437844 SN - 1866-8364 IS - 577 ER - TY - BOOK A1 - Klose, Dagmar A1 - Klostermann, Anke A1 - Engelmann, Anna-Maria A1 - Jeltsch, Gesche A1 - Dowall, Kathrin A1 - Meyer, Georg A1 - Glados, Andrea A1 - Fischer, Raul A1 - Hoffmann, Katrin A1 - Kaiser, Christoph A1 - Ladewig, Marco A1 - Skouras, Andreas A1 - Wienert, Christian A1 - Wilkening, Gregor A1 - Klaudius, Mathias A1 - Goldbeck, Johanna A1 - Duch, Sven A1 - Werfel, Claudia A1 - Viebig, Wenke A1 - Neumann, Katharina A1 - Dammnik, Sabine ED - Klose, Dagmar T1 - Antike so fern und doch so nah N2 - Historisches Denken entwickeln am Gegenstand der altorientalischen,griechischen und römischen Antike, das ist Anliegen der didaktischen Handreichung für die gymnasiale Oberstufe. Didaktisch-methodische Überlegungen, Sachinformationen und ein handlungsorientierter Materialteil bieten für Lehrer und Schüler ein ideenreiches Angebot zur Auswahl für einen interessegeleiteten Geschichtsunterricht. T3 - Perspektiven historischen Denkens und Lernens - 2 KW - Historisches Denken KW - Antike KW - Handlungsorientierung KW - Geschichtsunterricht in der gymnasialen Oberstufe Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-11179 SN - 978-3-939469-37-7 ER - TY - JOUR A1 - Krause, Florian A1 - Meyer, Marlene A1 - Bekkering, Harold A1 - Hunnius, Sabine A1 - Lindemann, Oliver T1 - Interaction between perceptual and motor magnitudes in early childhood JF - Cognitive development N2 - Recent research has suggested that all types of size-related information are linked by a generalised system that codes for domain-independent magnitudes. This generalized system is further suggested to be acquired through everyday sensorimotor experiences with contingencies of size-related information in the real world. The aim of the present study was to investigate the existence of this common representation and its impact on the coupling of perception and action in early childhood. According to an embodied view on magnitude representation, an association between perceived magnitude information and size-related motor features, such as applied motor force, should emerge as soon as motor control is sufficiently developed. This hypothesis was tested in 2.5- to 3-year-old toddlers by engaging them in a computer game-like experimental task in which they were required to move objects placed on a platform upwards by pressing a button. The amount of objects was varied systematically (small amount: 3 vs. large amount: 15) and the force children applied on the button while moving the objects was recorded. Importantly, the amount of applied force was not relevant for successfully playing the game. The analysis of the peak force revealed that motor responses were executed more forcefully when children were presented with a large amount of objects compared to a small amount, irrespective of the toddler’s motor abilities which were evaluated by two additional measures (force control and general fine motor skills). This general effect of perceived magnitude information on the task-irrelevant applied motor force confirms our notion that a link between perceptual and motor magnitudes exists already in early childhood and provides new evidence for a sensorimotor grounding of magnitude concepts. KW - Perception-action coupling KW - Generalised magnitude system KW - Embodied cognition KW - motor development Y1 - 2018 U6 - https://doi.org/10.1016/j.cogdev.2018.11.001 SN - 0885-2014 SN - 1879-226X VL - 49 SP - 11 EP - 19 PB - Elsevier Science CY - Amsterdam ER - TY - JOUR A1 - Meyer, Sabine A1 - Mainz, Andi A1 - Kehr, Jan-Christoph A1 - Suessmuth, Roderich A1 - Dittmann, Elke T1 - Prerequisites of Isopeptide Bond Formation in Microcystin Biosynthesis JF - ChemBioChem : a European journal of chemical biology N2 - The biosynthesis of the potent cyanobacterial hepatotoxin microcystin involves isopeptide bond formation through the carboxylic acid side chains of d-glutamate and -methyl d-aspartate. Analysis of the in vitro activation profiles of the two corresponding adenylation domains, McyE-A and McyB-A(2), either in a didomain or a tridomain context with the cognate thiolation domain and the upstream condensation domain revealed that substrate activation of both domains strictly depended on the presence of the condensation domains. We further identified two key amino acids in the binding pockets of both adenylation domains that could serve as a bioinformatic signature of isopeptide bond-forming modules incorporating d-glutamate or d-aspartate. Our findings further contribute to the understanding of the multifaceted role of condensation domains in nonribosomal peptide synthetase assembly lines. KW - amino acids KW - biosynthesis KW - cyanobacteria KW - nonribosomal peptide KW - substrate specificity Y1 - 2017 U6 - https://doi.org/10.1002/cbic.201700389 SN - 1439-4227 SN - 1439-7633 VL - 18 SP - 2376 EP - 2379 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Brothers, Soren M. A1 - Hilt, Sabine A1 - Meyer, Stephanie A1 - Köhler, Jan T1 - Plant community structure determines primary productivity in shallow, eutrophic lakes JF - Freshwater biology N2 - Regime shifts are commonly associated with the loss of submerged macrophytes in shallow lakes; yet, the effects of this on whole-lake primary productivity remain poorly understood. This study compares the annual gross primary production (GPP) of two shallow, eutrophic lakes with different plant community structures but similar nutrient concentrations. Daily GPP rates were substantially higher in the lake containing submerged macrophytes (58623gCm(-2)year(-1)) than in the lake featuring only phytoplankton and periphyton (40823gCm(-2)year(-1); P<0.0001). Comparing lake-centre diel oxygen curves to compartmental estimates of GPP confirmed that single-site oxygen curves may provide unreliable estimates of whole-lake GPP. The discrepancy between approaches was greatest in the macrophyte-dominated lake during the summer, with a high proportion of GPP occurring in the littoral zone. Our empirical results were used to construct a simple conceptual model relating GPP to nutrient availability for these alternative ecological regimes. This model predicted that lakes featuring submerged macrophytes may commonly support higher rates of GPP than phytoplankton-dominated lakes, but only within a moderate range of nutrient availability (total phosphorus ranging from 30 to 100gL(-1)) and with mean lake depths shallower than 3 or 4m. We conclude that shallow lakes with a submerged macrophyte-epiphyton complex may frequently support a higher annual primary production than comparable lakes that contain only phytoplankton and periphyton. We thus suggest that a regime shift involving the loss of submerged macrophytes may decrease the primary productivity of many lakes, with potential consequences for the entire food webs of these ecosystems. KW - macrophytes KW - oxygen curves KW - periphyton KW - regime shift KW - trophic status Y1 - 2013 U6 - https://doi.org/10.1111/fwb.12207 SN - 0046-5070 VL - 58 IS - 11 SP - 2264 EP - 2276 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Weiz, Annika R. A1 - Ishida, Keishi A1 - Quitterer, Felix A1 - Meyer, Sabine A1 - Kehr, Jan-Christoph A1 - Mueller, Kristian M. A1 - Groll, Michael A1 - Hertweck, Christian A1 - Dittmann-Thünemann, Elke T1 - Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions JF - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition N2 - Understanding and controlling proteolysis is an important goal in therapeutic chemistry. Among the natural products specifically inhibiting proteases microviridins are particularly noteworthy. Microviridins are ribosomally produced and posttranslationally modified peptides that are processed into a unique, cagelike architecture. Here, we report a combined rational and random mutagenesis approach that provides fundamental insights into selectivity-conferring moieties of microviridins. The potent variant microviridin J was co-crystallized with trypsin, and for the first time the three-dimensional structure of microviridins was determined and the mode of inhibition revealed. KW - cyanobacteria KW - peptide engineering KW - protease inhibitors KW - RiPPs KW - structure elucidation Y1 - 2014 U6 - https://doi.org/10.1002/anie.201309721 SN - 1433-7851 SN - 1521-3773 VL - 53 IS - 14 SP - 3735 EP - 3738 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kayhan Wagner, Ezgi A1 - Meyer, Marlene A1 - O’Reilly, J.X. A1 - Hunnius, Sabine A1 - Bekkering, Harold T1 - Nine-month-old infants update their predictive models of a changing environment JF - Developmental Cognitive Neuroscience : a journal for cognitive, affective and social developmental neuroscience N2 - Humans generate internal models of their environment to predict events in the world. As the environments change, our brains adjust to these changes by updating their internal models. Here, we investigated whether and how 9-month-old infants differentially update their models to represent a dynamic environment. Infants observed a predictable sequence of stimuli, which were interrupted by two types of cues. Following the update cue, the pattern was altered, thus, infants were expected to update their predictions for the upcoming stimuli. Because the pattern remained the same after the no-update cue, no subsequent updating was required. Infants showed an amplified negative central (Nc) response when the predictable sequence was interrupted. Late components such as the PSW were also evoked in response to unexpected stimuli; however, we found no evidence for a differential response to the informational value of surprising cues at later stages of processing. Infants rather learned that surprising cues always signal a change in the environment that requires updating. Interestingly, infants responded with an amplified neural response to the absence of an expected change, suggesting a top-down modulation of early sensory processing in infants. Our findings corroborate emerging evidence showing that infants build predictive models early in life. KW - Internal models KW - Predictive models KW - Predictive processing KW - Development KW - Event-Related potentials Y1 - 2019 U6 - https://doi.org/10.1016/j.dcn.2019.100680 SN - 1878-9293 SN - 1878-9307 VL - 38 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Brothers, Soren M. A1 - Hilt, Sabine A1 - Attermeyer, Katrin A1 - Grossart, Hans-Peter A1 - Kosten, Sarian A1 - Lischke, Betty A1 - Mehner, Thomas A1 - Meyer, Nils A1 - Scharnweber, Inga Kristin A1 - Köhler, Jan T1 - A regime shift from macrophyte to phytoplankton dominance enhances carbon burial in a shallow, eutrophic lake JF - Ecosphere : the magazine of the International Ecology University N2 - Ecological regime shifts and carbon cycling in aquatic systems have both been subject to increasing attention in recent years, yet the direct connection between these topics has remained poorly understood. A four-fold increase in sedimentation rates was observed within the past 50 years in a shallow eutrophic lake with no surface in-or outflows. This change coincided with an ecological regime shift involving the complete loss of submerged macrophytes, leading to a more turbid, phytoplankton-dominated state. To determine whether the increase in carbon (C) burial resulted from a comprehensive transformation of C cycling pathways in parallel to this regime shift, we compared the annual C balances (mass balance and ecosystem budget) of this turbid lake to a similar nearby lake with submerged macrophytes, a higher transparency, and similar nutrient concentrations. C balances indicated that roughly 80% of the C input was permanently buried in the turbid lake sediments, compared to 40% in the clearer macrophyte-dominated lake. This was due to a higher measured C burial efficiency in the turbid lake, which could be explained by lower benthic C mineralization rates. These lower mineralization rates were associated with a decrease in benthic oxygen availability coinciding with the loss of submerged macrophytes. In contrast to previous assumptions that a regime shift to phytoplankton dominance decreases lake heterotrophy by boosting whole-lake primary production, our results suggest that an equivalent net metabolic shift may also result from lower C mineralization rates in a shallow, turbid lake. The widespread occurrence of such shifts may thus fundamentally alter the role of shallow lakes in the global C cycle, away from channeling terrestrial C to the atmosphere and towards burying an increasing amount of C. KW - calcite precipitation KW - CO2 emissions KW - global carbon cycle KW - metabolism KW - regime shift KW - sedimentation KW - submerged macrophytes KW - temperate zone KW - trophic status Y1 - 2013 U6 - https://doi.org/10.1890/ES13-00247.1 SN - 2150-8925 VL - 4 IS - 11 PB - Wiley CY - Washington ER - TY - JOUR A1 - Brothers, Soren M. A1 - Koehler, J. A1 - Attermeyer, Katrin A1 - Grossart, Hans-Peter A1 - Mehner, T. A1 - Meyer, N. A1 - Scharnweber, Inga Kristin A1 - Hilt, Sabine T1 - A feedback loop links brownification and anoxia in a temperate, shallow lake JF - Limnology and oceanography N2 - This study examines a natural, rapid, fivefold increase in dissolved organic carbon (DOC) concentrations in a temperate shallow lake, describing the processes by which increased DOC resulted in anoxic conditions and altered existing carbon cycling pathways. High precipitation for two consecutive years led to rising water levels and the flooding of adjacent degraded peatlands. Leaching from the flooded soils provided an initial increase in DOC concentrations (from a 2010 mean of 12 +/- 1 mg L-1 to a maximum concentration of 53 mg L-1 by June 2012). Increasing water levels, DOC, and phytoplankton concentrations reduced light reaching the sediment surface, eliminating most benthic primary production and promoting anoxia in the hypolimnion. From January to June 2012 there was a sudden increase in total phosphorus (from 57 mg L-1 to 216 mg L-1), DOC (from 24.6 mg L-1 to 53 mg L-1), and iron (from 0.12 mg L-1 to 1.07 mg L-1) concentrations, without any further large fluxes in water levels. We suggest that anoxic conditions at the sediment surface and flooded soils produced a dramatic release of these chemicals that exacerbated brownification and eutrophication, creating anoxic conditions that persisted roughly 6 months below a water depth of 1 m and extended periodically to the water surface. This brownification-anoxia feedback loop resulted in a near-complete loss of macroinvertebrate and fish populations, and increased surface carbon dioxide (CO2) emissions by an order of magnitude relative to previous years. Y1 - 2014 U6 - https://doi.org/10.4319/lo.2014.59.4.1388 SN - 0024-3590 SN - 1939-5590 VL - 59 IS - 4 SP - 1388 EP - 1398 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Aust, Gottfried A1 - Heinemann, Steffi A1 - Hennies, Johannes A1 - Penke, Martina A1 - Rothweiler, Monika A1 - Wimmer, Eva A1 - Hess, Markus A1 - Becker, Maryanne A1 - Ehrmann-Neuhoff, Brigitte A1 - Hamann, Elke A1 - Wachtlin, Bianka A1 - Schäfer, Blanca A1 - Würzner, Kay-Michael A1 - Heister, Julian A1 - Schroeder, Sascha A1 - Düsterhöft, Stefanie A1 - Trüggelmann, Maria A1 - Richter, Kerstin A1 - Gagarina, Natalʹja Vladimirovna A1 - Posse, Dorothea A1 - Topaj, Nathalie A1 - Acikgöz, Duygu A1 - Neumann, Charleen A1 - Baumann, Jeannine A1 - Meyer, Sarah A1 - Siegmüller, Julia A1 - Kösterke-Buchardt, Antje A1 - Jung, Kristina A1 - Jassens, Frank A1 - Golchert, Kristin A1 - Wolff von Gudenberg, Alexander A1 - Schmidt, Sabine A1 - Kisielewicz, Daria A1 - Heide, Judith A1 - Göldner, Angie A1 - Ostermann, Anja ED - Adelt, Anne ED - Fritzsche, Tom ED - Roß, Jennifer ED - Düsterhöft, Stefanie T1 - Spektrum Patholinguistik = Schwerpunktthema: Hören – Zuhören – Dazugehören : Sprachtherapie bei Hörstörungen und Cochlea-Implantat T1 - Spektrum Patholinguistik = Focus topic: hear – listen – participate : language therapy for people with hearing loss or Cochlear Implants N2 - Das Herbsttreffen Patholinguistik wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Das 7. Herbsttreffen mit dem Schwerpunktthema "Hören – Zuhören – Dazugehören: Sprachtherapie bei Hörstörungen und Cochlea-Implantat" fand am 16.11.2013 in Potsdam statt. Der vorliegende Tagungsband beinhaltet die sechs Vorträge zum Schwerpunktthema aus verschiedenen Perspektiven: der medizinischen, der therapeutischen, der wissenschaftlichen sowie der von Betroffenen. Weiterhin sind die Beiträge der Posterpräsentationen zu Themen der sprachtherapeutischen Forschung und Praxis abgedruckt. N2 - The 'Herbsttreffen Patholinguistik' is an annual conference organized by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl) since 2007. The seventh edition of this event took place on November 16 2013 in Potsdam and had as its focus topic "Hear – Listen– Participate: Language Therapy for People with Hearing Loss or Cochlear Implants". These proceedings contain the keynote talks covering the medical, therapeutic, and scientific perspectives as well as the view from two users of cochlear implants. The second part comprises the contributions to the poster session from different areas of speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 7 KW - Patholinguistik KW - Sprachtherapie KW - Hörstörungen KW - Cochlea-Implantat KW - Hören KW - patholinguistics KW - speech/language therapy KW - hearing loss KW - cochlear implant KW - hearing Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70629 SN - 978-3-86956-294-0 SN - 1869-3822 SN - 1866-9433 IS - 7 PB - Universitätsverlag Potsdam CY - Potsdam ER -