TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Psychische und familiäre Risiken für Kinder von Frauen mit Epilepsie? : Ergebnisse einer Längsschnittstudie Y1 - 2007 ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Zimmer, Ulrike A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Helge, Hans T1 - Wachstum von Kindern nach Antiepileptikaexpositon während der Schwangerschaft Y1 - 2004 UR - http://www.springerlink.com/(yvnzjbnfgnyul545naopdtrh)/media/MM8XD75N4G1KTGD93ECN/Contributions/M/E/J/3/ MEJ3UXAT3PLU3R0T.pdf U6 - https://doi.org/10.1007/s00112-003-0837-4 SN - 0026-9298 ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Zimmer, Ulrike A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Helge, Hans T1 - Growth of children exposed to antiepileptic medications in the womb N2 - Antiepileptic drugs are suspected of being weakly teratogenic in humans. In a prospective longitudinal study, we assessed growth parameters of children from birth to adolescence who had been prenatally exposed to various antiepileptic drugs and compared them to non-exposed control children matched for parental body length, social status, and maternal nicotine consumption during pregnancy as well as for parity. While no differences in mean head circumferences could be ascertained in the group of exposed children at 1, 6, and 14 years, differences were measured in body length at I year. The differences were more pronounced for both measurements when therapy forms and types of drugs were considered: polytherapy and phenobarbitone therapy (which was usually part of polytherapy) of the mother appeared to have an influence on the children's growth. Children exposed to polytherapy and phenobarbitone (as single drug or as part of polytherapy) had smaller head circumferences and were shorter. We assume an influence of polytherapy and phenobarbitone therapy taken by the epileptic woman during pregnancy on the growth of the child into adolescence Y1 - 2004 SN - 0026-9298 ER - TY - JOUR A1 - Rauh, Hellgard A1 - Koch, Sabine A1 - Titze, Karl A1 - Steinhausen, Hans-CHristoph A1 - Lehmkuhl, Ulrike T1 - Teratogenität von Antiepileptika : subtile und verzögerte Entwicklungsstörungen Y1 - 2002 SN - 0302-4350 ER - TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Helge, Hans A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Steinhausen, Hans-Christoph T1 - Prenatal and familial risks of children born by epileptic mothers : long term effects on the cognitive development Y1 - 2008 UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2007.02020.x/pdf U6 - https://doi.org/10.1111/j.1469-8749.2007.02020.x ER - TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Psychische und familäre Belastungen bei Kindern und Müttern mit Epilepsie Y1 - 2001 ER - TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Soziofamiliäre und epilepsiespezifische Belastungen von Frauen mit Epilepsie Y1 - 2001 ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Treuter, S. A1 - Schröder, M. A1 - Zimmermann, Ralf B. A1 - Steinhausen, Hans-Christoph A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard T1 - Maternal use of valproate during pregnancy, risk of major malformations, and brain disorder Y1 - 2000 ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Schröder, Michael A1 - Zimmermann, Ralf B. A1 - Lehmkuhl, Gerd A1 - Rauh, Hellgard T1 - Longterm neurological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents Y1 - 1999 SN - 0013-9580 ER - TY - JOUR A1 - Neusser, David A1 - Sun, Bowen A1 - Tan, Wen Liang A1 - Thomsen, Lars A1 - Schultz, Thorsten A1 - Perdigon-Toro, Lorena A1 - Koch, Norbert A1 - Shoaee, Safa A1 - McNeill, Christopher R. A1 - Neher, Dieter A1 - Ludwigs, Sabine T1 - Spectroelectrochemically determined energy levels of PM6:Y6 blends and their relevance to solar cell performance JF - Journal of materials chemistry : C, Materials for optical and electronic devices N2 - Recent advances in organic solar cell performance have been mainly driven forward by combining high-performance p-type donor-acceptor copolymers (e.g.PM6) and non-fullerene small molecule acceptors (e.g.Y6) as bulk-heterojunction layers. A general observation in such devices is that the device performance, e.g., the open-circuit voltage, is strongly dependent on the processing solvent. While the morphology is a typically named key parameter, the energetics of donor-acceptor blends are equally important, but less straightforward to access in the active multicomponent layer. Here, we propose to use spectral onsets during electrochemical cycling in a systematic spectroelectrochemical study of blend films to access the redox behavior and the frontier orbital energy levels of the individual compounds. Our study reveals that the highest occupied molecular orbital offset (Delta E-HOMO) in PM6:Y6 blends is similar to 0.3 eV, which is comparable to the binding energy of Y6 excitons and therefore implies a nearly zero driving force for the dissociation of Y6 excitons. Switching the PM6 orientation in the blend films from face-on to edge-on in bulk has only a minor influence on the positions of the energy levels, but shows significant differences in the open circuit voltage of the device. We explain this phenomenon by the different interfacial molecular orientations, which are known to affect the non-radiative decay rate of the charge-transfer state. We compare our results to ultraviolet photoelectron spectroscopy data, which shows distinct differences in the HOMO offsets in the PM6:Y6 blend compared to neat films. This highlights the necessity to measure the energy levels of the individual compounds in device-relevant blend films. Y1 - 2022 U6 - https://doi.org/10.1039/d2tc01918c SN - 2050-7526 SN - 2050-7534 VL - 10 IS - 32 SP - 11565 EP - 11578 PB - Royal Society of Chemistry CY - Cambridge ER -