TY  - JOUR
A1  - Arlt, Olga
A1  - Schwiebs, Anja
A1  - Japtok, Lukasz
A1  - Rueger, Katja
A1  - Katzy, Elisabeth
A1  - Kleuser, Burkhard
A1  - Radeke, Heinfried H.
T1  - Sphingosine-1-Phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo
JF  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The major functions of these antigen presenting cells are the capture, endosomal processing and presentation of antigens, providing them an exclusive ability to provoke adaptive immune responses and to induce and control tolerance. Immature DCs capture and process antigens, migrate towards secondary lymphoid organs where they present antigens to naive T cells in a well synchronized sequence of procedures referred to as maturation. Indeed, recent research indicated that sphingolipids are modulators of essential steps in DC homeostasis. It has been recognized that sphingolipids not only modulate the development of DC subtypes from precursor cells but also influence functional activities of DCs such as antigen capture, and cytokine profiling. Thus, it is not astonishing that sphingolipids and sphingolipid metabolism play a substantial role in inflammatory diseases that are modulated by DCs. Here we highlight the function of sphingosine 1-phosphate (S1P) on DC homeostasis and the role of SIP and SW metabolism in inflammatory diseases.
KW  - Sphingosine-1-phosphate
KW  - Dendritic cells
KW  - Fingolimod
KW  - IL-12
KW  - Inflammation
Y1  - 2014
U6  - https://doi.org/10.1159/000362982
SN  - 1015-8987
SN  - 1421-9778
VL  - 34
IS  - 1
SP  - 27
EP  - 44
PB  - Karger
CY  - Basel
ER  -