TY - JOUR A1 - Penone, Caterina A1 - Allan, Eric A1 - Soliveres, Santiago A1 - Felipe-Lucia, Maria R. A1 - Gossner, Martin M. A1 - Seibold, Sebastian A1 - Simons, Nadja K. A1 - Schall, Peter A1 - van der Plas, Fons A1 - Manning, Peter A1 - Manzanedo, Ruben D. A1 - Boch, Steffen A1 - Prati, Daniel A1 - Ammer, Christian A1 - Bauhus, Juergen A1 - Buscot, Francois A1 - Ehbrecht, Martin A1 - Goldmann, Kezia A1 - Jung, Kirsten A1 - Mueller, Joerg A1 - Mueller, Joerg C. A1 - Pena, Rodica A1 - Polle, Andrea A1 - Renner, Swen C. A1 - Ruess, Liliane A1 - Schoenig, Ingo A1 - Schrumpf, Marion A1 - Solly, Emily F. A1 - Tschapka, Marco A1 - Weisser, Wolfgang W. A1 - Wubet, Tesfaye A1 - Fischer, Markus T1 - Specialisation and diversity of multiple trophic groups are promoted by different forest features JF - Ecology letters N2 - While forest management strongly influences biodiversity, it remains unclear how the structural and compositional changes caused by management affect different community dimensions (e.g. richness, specialisation, abundance or completeness) and how this differs between taxa. We assessed the effects of nine forest features (representing stand structure, heterogeneity and tree composition) on thirteen above- and belowground trophic groups of plants, animals, fungi and bacteria in 150 temperate forest plots differing in their management type. Canopy cover decreased light resources, which increased community specialisation but reduced overall diversity and abundance. Features increasing resource types and diversifying microhabitats (admixing of oaks and conifers) were important and mostly affected richness. Belowground groups responded differently to those aboveground and had weaker responses to most forest features. Our results show that we need to consider forest features rather than broad management types and highlight the importance of considering several groups and community dimensions to better inform conservation. KW - biodiversity exploratories KW - dark diversity KW - forest management KW - global change KW - land-use KW - multidiversity KW - specialisation KW - temperate forests Y1 - 2018 U6 - https://doi.org/10.1111/ele.13182 SN - 1461-023X SN - 1461-0248 VL - 22 IS - 1 SP - 170 EP - 180 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Bernhard, Nadine A1 - Moskwa, Lisa-Marie A1 - Schmidt, Karsten A1 - Oeser, Ralf Andreas A1 - Aburto, Felipe A1 - Bader, Maaike Y. A1 - Baumann, Karen A1 - von Blanckenburg, Friedhelm A1 - Boy, Jens A1 - van den Brink, Liesbeth A1 - Brucker, Emanuel A1 - Buedel, Burkhard A1 - Canessa, Rafaella A1 - Dippold, Michaela A. A1 - Ehlers, Todd A1 - Fuentes, Juan P. A1 - Godoy, Roberto A1 - Jung, Patrick A1 - Karsten, Ulf A1 - Koester, Moritz A1 - Kuzyakov, Yakov A1 - Leinweber, Peter A1 - Neidhardt, Harald A1 - Matus, Francisco A1 - Mueller, Carsten W. A1 - Oelmann, Yvonne A1 - Oses, Romulo A1 - Osses, Pablo A1 - Paulino, Leandro A1 - Samolov, Elena A1 - Schaller, Mirjam A1 - Schmid, Manuel A1 - Spielvogel, Sandra A1 - Spohn, Marie A1 - Stock, Svenja A1 - Stroncik, Nicole A1 - Tielboerger, Katja A1 - Uebernickel, Kirstin A1 - Scholten, Thomas A1 - Seguel, Oscar A1 - Wagner, Dirk A1 - Kühn, Peter T1 - Pedogenic and microbial interrelations to regional climate and local topography BT - New insights from a climate gradient (arid to humid) along the Coastal Cordillera of Chile JF - Catena : an interdisciplinary journal of soil science, hydrology, geomorphology focusing on geoecology and landscape evolution N2 - The effects of climate and topography on soil physico-chemical and microbial parameters were studied along an extensive latitudinal climate gradient in the Coastal Cordillera of Chile (26 degrees-38 degrees S). The study sites encompass arid (Pan de Azucar), semiarid (Santa Gracia), mediterranean (La Campana) and humid (Nahuelbuta) climates and vegetation, ranging from arid desert, dominated by biological soil crusts (biocrusts), semiarid shrubland and mediterranean sclerophyllous forest, where biocrusts are present but do have a seasonal pattern to temperate-mixed forest, where biocrusts only occur as an early pioneering development stage after disturbance. All soils originate from granitic parent materials and show very strong differences in pedogenesis intensity and soil depth. Most of the investigated physical, chemical and microbiological soil properties showed distinct trends along the climate gradient. Further, abrupt changes between the arid northernmost study site and the other semi-arid to humid sites can be shown, which indicate non-linearity and thresholds along the climate gradient. Clay and total organic carbon contents (TOC) as well as Ah horizons and solum depths increased from arid to humid climates, whereas bulk density (BD), pH values and base saturation (BS) decreased. These properties demonstrate the accumulation of organic matter, clay formation and element leaching as key-pedogenic processes with increasing humidity. However, the soils in the northern arid climate do not follow this overall latitudinal trend, because texture and BD are largely controlled by aeolian input of dust and sea salts spray followed by the formation of secondary evaporate minerals. Total soil DNA concentrations and TOC increased from arid to humid sites, while areal coverage by biocrusts exhibited an opposite trend. Relative bacterial and archaeal abundances were lower in the arid site, but for the other sites the local variability exceeds the variability along the climate gradient. Differences in soil properties between topographic positions were most pronounced at the study sites with the mediterranean and humid climate, whereas microbial abundances were independent on topography across all study sites. In general, the regional climate is the strongest controlling factor for pedogenesis and microbial parameters in soils developed from the same parent material. Topographic position along individual slopes of limited length augmented this effect only under humid conditions, where water erosion likely relocated particles and elements downward. The change from alkaline to neutral soil pH between the arid and the semi-arid site coincided with qualitative differences in soil formation as well as microbial habitats. This also reflects non-linear relationships of pedogenic and microbial processes in soils depending on climate with a sharp threshold between arid and semi-arid conditions. Therefore, the soils on the transition between arid and semi-arid conditions are especially sensitive and may be well used as indicators of long and medium-term climate changes. Concluding, the unique latitudinal precipitation gradient in the Coastal Cordillera of Chile is predestined to investigate the effects of the main soil forming factor - climate - on pedogenic processes. KW - Climate KW - Topography KW - Soil texture KW - Total organic carbon KW - Carbon isotope ratio (delta C-13(TOC)) KW - Microbial abundance Y1 - 2018 U6 - https://doi.org/10.1016/j.catena.2018.06.018 SN - 0341-8162 SN - 1872-6887 VL - 170 SP - 335 EP - 355 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Tucker, Marlee A. A1 - Boehning-Gaese, Katrin A1 - Fagan, William F. A1 - Fryxell, John M. A1 - Van Moorter, Bram A1 - Alberts, Susan C. A1 - Ali, Abdullahi H. A1 - Allen, Andrew M. A1 - Attias, Nina A1 - Avgar, Tal A1 - Bartlam-Brooks, Hattie A1 - Bayarbaatar, Buuveibaatar A1 - Belant, Jerrold L. A1 - Bertassoni, Alessandra A1 - Beyer, Dean A1 - Bidner, Laura A1 - van Beest, Floris M. A1 - Blake, Stephen A1 - Blaum, Niels A1 - Bracis, Chloe A1 - Brown, Danielle A1 - de Bruyn, P. J. Nico A1 - Cagnacci, Francesca A1 - Calabrese, Justin M. A1 - Camilo-Alves, Constanca A1 - Chamaille-Jammes, Simon A1 - Chiaradia, Andre A1 - Davidson, Sarah C. A1 - Dennis, Todd A1 - DeStefano, Stephen A1 - Diefenbach, Duane A1 - Douglas-Hamilton, Iain A1 - Fennessy, Julian A1 - Fichtel, Claudia A1 - Fiedler, Wolfgang A1 - Fischer, Christina A1 - Fischhoff, Ilya A1 - Fleming, Christen H. A1 - Ford, Adam T. A1 - Fritz, Susanne A. A1 - Gehr, Benedikt A1 - Goheen, Jacob R. A1 - Gurarie, Eliezer A1 - Hebblewhite, Mark A1 - Heurich, Marco A1 - Hewison, A. J. Mark A1 - Hof, Christian A1 - Hurme, Edward A1 - Isbell, Lynne A. A1 - Janssen, Rene A1 - Jeltsch, Florian A1 - Kaczensky, Petra A1 - Kane, Adam A1 - Kappeler, Peter M. A1 - Kauffman, Matthew A1 - Kays, Roland A1 - Kimuyu, Duncan A1 - Koch, Flavia A1 - Kranstauber, Bart A1 - LaPoint, Scott A1 - Leimgruber, Peter A1 - Linnell, John D. C. A1 - Lopez-Lopez, Pascual A1 - Markham, A. Catherine A1 - Mattisson, Jenny A1 - Medici, Emilia Patricia A1 - Mellone, Ugo A1 - Merrill, Evelyn A1 - Mourao, Guilherme de Miranda A1 - Morato, Ronaldo G. A1 - Morellet, Nicolas A1 - Morrison, Thomas A. A1 - Diaz-Munoz, Samuel L. A1 - Mysterud, Atle A1 - Nandintsetseg, Dejid A1 - Nathan, Ran A1 - Niamir, Aidin A1 - Odden, John A1 - Oliveira-Santos, Luiz Gustavo R. A1 - Olson, Kirk A. A1 - Patterson, Bruce D. A1 - de Paula, Rogerio Cunha A1 - Pedrotti, Luca A1 - Reineking, Bjorn A1 - Rimmler, Martin A1 - Rogers, Tracey L. A1 - Rolandsen, Christer Moe A1 - Rosenberry, Christopher S. A1 - Rubenstein, Daniel I. A1 - Safi, Kamran A1 - Said, Sonia A1 - Sapir, Nir A1 - Sawyer, Hall A1 - Schmidt, Niels Martin A1 - Selva, Nuria A1 - Sergiel, Agnieszka A1 - Shiilegdamba, Enkhtuvshin A1 - Silva, Joao Paulo A1 - Singh, Navinder A1 - Solberg, Erling J. A1 - Spiegel, Orr A1 - Strand, Olav A1 - Sundaresan, Siva A1 - Ullmann, Wiebke A1 - Voigt, Ulrich A1 - Wall, Jake A1 - Wattles, David A1 - Wikelski, Martin A1 - Wilmers, Christopher C. A1 - Wilson, John W. A1 - Wittemyer, George A1 - Zieba, Filip A1 - Zwijacz-Kozica, Tomasz A1 - Mueller, Thomas T1 - Moving in the Anthropocene BT - global reductions in terrestrial mammalian movements JF - Science N2 - Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission. Y1 - 2018 U6 - https://doi.org/10.1126/science.aam9712 SN - 0036-8075 SN - 1095-9203 VL - 359 IS - 6374 SP - 466 EP - 469 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Noonan, Michael J. A1 - Tucker, Marlee A. A1 - Fleming, Christen H. A1 - Akre, Thomas S. A1 - Alberts, Susan C. A1 - Ali, Abdullahi H. A1 - Altmann, Jeanne A1 - Antunes, Pamela Castro A1 - Belant, Jerrold L. A1 - Beyer, Dean A1 - Blaum, Niels A1 - Boehning-Gaese, Katrin A1 - Cullen Jr, Laury A1 - de Paula, Rogerio Cunha A1 - Dekker, Jasja A1 - Drescher-Lehman, Jonathan A1 - Farwig, Nina A1 - Fichtel, Claudia A1 - Fischer, Christina A1 - Ford, Adam T. A1 - Goheen, Jacob R. A1 - Janssen, Rene A1 - Jeltsch, Florian A1 - Kauffman, Matthew A1 - Kappeler, Peter M. A1 - Koch, Flavia A1 - LaPoint, Scott A1 - Markham, A. Catherine A1 - Medici, Emilia Patricia A1 - Morato, Ronaldo G. A1 - Nathan, Ran A1 - Oliveira-Santos, Luiz Gustavo R. A1 - Olson, Kirk A. A1 - Patterson, Bruce D. A1 - Paviolo, Agustin A1 - Ramalho, Emiliano Estero A1 - Rosner, Sascha A1 - Schabo, Dana G. A1 - Selva, Nuria A1 - Sergiel, Agnieszka A1 - da Silva, Marina Xavier A1 - Spiegel, Orr A1 - Thompson, Peter A1 - Ullmann, Wiebke A1 - Zieba, Filip A1 - Zwijacz-Kozica, Tomasz A1 - Fagan, William F. A1 - Mueller, Thomas A1 - Calabrese, Justin M. T1 - A comprehensive analysis of autocorrelation and bias in home range estimation JF - Ecological monographs : a publication of the Ecological Society of America. N2 - Home range estimation is routine practice in ecological research. While advances in animal tracking technology have increased our capacity to collect data to support home range analysis, these same advances have also resulted in increasingly autocorrelated data. Consequently, the question of which home range estimator to use on modern, highly autocorrelated tracking data remains open. This question is particularly relevant given that most estimators assume independently sampled data. Here, we provide a comprehensive evaluation of the effects of autocorrelation on home range estimation. We base our study on an extensive data set of GPS locations from 369 individuals representing 27 species distributed across five continents. We first assemble a broad array of home range estimators, including Kernel Density Estimation (KDE) with four bandwidth optimizers (Gaussian reference function, autocorrelated‐Gaussian reference function [AKDE], Silverman's rule of thumb, and least squares cross‐validation), Minimum Convex Polygon, and Local Convex Hull methods. Notably, all of these estimators except AKDE assume independent and identically distributed (IID) data. We then employ half‐sample cross‐validation to objectively quantify estimator performance, and the recently introduced effective sample size for home range area estimation ( N̂ area ) to quantify the information content of each data set. We found that AKDE 95% area estimates were larger than conventional IID‐based estimates by a mean factor of 2. The median number of cross‐validated locations included in the hold‐out sets by AKDE 95% (or 50%) estimates was 95.3% (or 50.1%), confirming the larger AKDE ranges were appropriately selective at the specified quantile. Conversely, conventional estimates exhibited negative bias that increased with decreasing N̂ area. To contextualize our empirical results, we performed a detailed simulation study to tease apart how sampling frequency, sampling duration, and the focal animal's movement conspire to affect range estimates. Paralleling our empirical results, the simulation study demonstrated that AKDE was generally more accurate than conventional methods, particularly for small N̂ area. While 72% of the 369 empirical data sets had >1,000 total observations, only 4% had an N̂ area >1,000, where 30% had an N̂ area <30. In this frequently encountered scenario of small N̂ area, AKDE was the only estimator capable of producing an accurate home range estimate on autocorrelated data. KW - animal movement KW - kernel density estimation KW - local convex hull KW - minimum convex polygon KW - range distribution KW - space use KW - telemetry KW - tracking data Y1 - 2018 U6 - https://doi.org/10.1002/ecm.1344 SN - 0012-9615 SN - 1557-7015 VL - 89 IS - 2 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Nickerson, David A1 - Atalag, Koray A1 - de Bono, Bernard A1 - Geiger, Joerg A1 - Goble, Carole A1 - Hollmann, Susanne A1 - Lonien, Joachim A1 - Mueller, Wolfgang A1 - Regierer, Babette A1 - Stanford, Natalie J. A1 - Golebiewski, Martin A1 - Hunter, Peter T1 - The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable JF - Interface focus N2 - Reconstructing and understanding the Human Physiome virtually is a complex mathematical problem, and a highly demanding computational challenge. Mathematical models spanning from the molecular level through to whole populations of individuals must be integrated, then personalized. This requires interoperability with multiple disparate and geographically separated data sources, and myriad computational software tools. Extracting and producing knowledge from such sources, even when the databases and software are readily available, is a challenging task. Despite the difficulties, researchers must frequently perform these tasks so that available knowledge can be continually integrated into the common framework required to realize the Human Physiome. Software and infrastructures that support the communities that generate these, together with their underlying standards to format, describe and interlink the corresponding data and computer models, are pivotal to the Human Physiome being realized. They provide the foundations for integrating, exchanging and re-using data and models efficiently, and correctly, while also supporting the dissemination of growing knowledge in these forms. In this paper, we explore the standards, software tooling, repositories and infrastructures that support this work, and detail what makes them vital to realizing the Human Physiome. KW - Human Physiome KW - standards KW - repositories KW - service infrastructure KW - reproducible science KW - managing big data Y1 - 2016 U6 - https://doi.org/10.1098/rsfs.2015.0103 SN - 2042-8898 SN - 2042-8901 VL - 6 SP - 57 EP - 61 PB - Royal Society CY - London ER - TY - JOUR A1 - Weisshuhn, Peter A1 - Mueller, Felix A1 - Wiggering, Hubert T1 - Ecosystem Vulnerability Review BT - proposal of an interdisciplinary ecosystem assessment approach JF - Environmental Management N2 - To safeguard the sustainable use of ecosystems and their services, early detection of potentially damaging changes in functional capabilities is needed. To support a proper ecosystem management, the analysis of an ecosystem’s vulnerability provide information on its weaknesses as well as on its capacity to recover after suffering an impact. However, the application of the vulnerability concept to ecosystems is still an emerging topic. After providing background on the vulnerability concept, we summarize existing ecosystem vulnerability research on the basis of a systematic literature review with a special focus on ecosystem type, disciplinary background, and more detailed definition of the ecosystem vulnerability components. Using the Web of ScienceTM Core Collection, we overviewed the literature from 1991 onwards but used the 5 years from 2011 to 2015 for an in-depth analysis, including 129 articles. We found that ecosystem vulnerability analysis has been applied most notably in conservation biology, climate change research, and ecological risk assessments, pinpointing a limited spreading across the environmental sciences. It occurred primarily within marine and freshwater ecosystems. To avoid confusion, we recommend using the unambiguous term ecosystem vulnerability rather than ecological, environmental, population, or community vulnerability. Further, common ground has been identified, on which to define the ecosystem vulnerability components exposure, sensitivity, and adaptive capacity. We propose a framework for ecosystem assessments that coherently connects the concepts of vulnerability, resilience, and adaptability as different ecosystem responses. A short outlook on the possible operationalization of the concept by ecosystem vulnerabilty indices, and a conclusion section complete the review. KW - Environmental vulnerability KW - Ecological vulnerability KW - Ecosystem response KW - Interdisciplinarity KW - Resilience KW - Adaptability Y1 - 2018 U6 - https://doi.org/10.1007/s00267-018-1023-8 SN - 0364-152X SN - 1432-1009 VL - 61 IS - 6 SP - 904 EP - 915 PB - Springer CY - New York ER - TY - JOUR A1 - Heinrichs, Steffi A1 - Ammer, Christian A1 - Mund, Martina A1 - Boch, Steffen A1 - Budde, Sabine A1 - Fischer, Markus A1 - Mueller, Joerg A1 - Schoening, Ingo A1 - Schulze, Ernst-Detlef A1 - Schmidt, Wolfgang A1 - Weckesser, Martin A1 - Schall, Peter T1 - Landscape-Scale Mixtures of Tree Species are More Effective than Stand-Scale Mixtures for Biodiversity of Vascular Plants, Bryophytes and Lichens JF - Forests N2 - Tree species diversity can positively affect the multifunctionality of forests. This is why conifer monocultures of Scots pine and Norway spruce, widely promoted in Central Europe since the 18th and 19th century, are currently converted into mixed stands with naturally dominant European beech. Biodiversity is expected to benefit from these mixtures compared to pure conifer stands due to increased abiotic and biotic resource heterogeneity. Evidence for this assumption is, however, largely lacking. Here, we investigated the diversity of vascular plants, bryophytes and lichens at the plot (alpha diversity) and at the landscape (gamma diversity) level in pure and mixed stands of European beech and conifer species (Scots pine, Norway spruce, Douglas fir) in four regions in Germany. We aimed to identify compositions of pure and mixed stands in a hypothetical forest landscape that can optimize gamma diversity of vascular plants, bryophytes and lichens within regions. Results show that gamma diversity of the investigated groups is highest when a landscape comprises different pure stands rather than tree species mixtures at the stand scale. Species mainly associated with conifers rely on light regimes that are only provided in pure conifer forests, whereas mixtures of beech and conifers are more similar to beech stands. Combining pure beech and pure conifer stands at the landscape scale can increase landscape level biodiversity and conserve species assemblages of both stand types, while landscapes solely composed of stand scale tree species mixtures could lead to a biodiversity reduction of a combination of investigated groups of 7 up to 20%. KW - Fagus sylvatica KW - Pinus sylvestris KW - Picea abies KW - Pseudotsuga menziesii KW - forest management KW - tree species diversity KW - forest conversion KW - gamma diversity KW - landscape scale KW - Biodiversity Exploratories Y1 - 2019 U6 - https://doi.org/10.3390/f10010073 SN - 1999-4907 VL - 10 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Schwarze, Thomas A1 - Mertens, Monique A1 - Mueller, Peter A1 - Riemer, Janine A1 - Wessig, Pablo A1 - Holdt, Hans-Jürgen T1 - Highly K+-Selective Fluorescent Probes for Lifetime Sensing of K+ in Living Cells JF - Chemistry - a European journal N2 - The new K+-selective fluorescent probes 1 and 2 were obtained by Cu-I-catalyzed 1,3-dipolar azide alkyne cycloaddition (CuAAC) reactions of an alkyne-substituted [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) ester fluorophore with azido-functionalized N-phenylaza-18-crown-6 ether and N-(o-isopropoxy) phenylaza-18-crown-6 ether, respectively. Probes 1 and 2 allow the detection of K+ in the presence of Na+ in water by fluorescence enhancement (2.2 for 1 at 2000mm K+ and 2.5 for 2 at 160mm K+). Fluorescence lifetime measurements in the absence and presence of K+ revealed bi-exponential decay kinetics with similar lifetimes, however with different proportions changing the averaged fluorescence decay times ((f(av))). For 1 a decrease of (f(av)) from 12.4 to 9.3ns and for 2 an increase from 17.8 to 21.8ns was observed. Variation of the substituent in ortho position of the aniline unit of the N-phenylaza-18-crown-6 host permits the modulation of the K-d value for a certain K+ concentration. For example, substitution of H in 1 by the isopropoxy group (2) decreased the K-d value from >300mm to 10mm. 2 was chosen for studying the efflux of K+ from human red blood cells (RBC). Upon addition of the Ca2+ ionophor ionomycin to a RBC suspension in a buffer containing Ca2+, the fluorescence of 2 slightly rose within 10min, however, after 120min a significant increase was observed. KW - electron transfer KW - fluorescence lifetime KW - fluorescent probes KW - living cells KW - potassium Y1 - 2017 U6 - https://doi.org/10.1002/chem.201704368 SN - 0947-6539 SN - 1521-3765 VL - 23 SP - 17186 EP - 17190 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Koenig, Julian A1 - Abler, Birgit A1 - Agartz, Ingrid A1 - akerstedt, Torbjorn A1 - Andreassen, Ole A. A1 - Anthony, Mia A1 - Baer, Karl-Juergen A1 - Bertsch, Katja A1 - Brown, Rebecca C. A1 - Brunner, Romuald A1 - Carnevali, Luca A1 - Critchley, Hugo D. A1 - Cullen, Kathryn R. A1 - de Geus, Eco J. C. A1 - de la Cruz, Feliberto A1 - Dziobek, Isabel A1 - Ferger, Marc D. A1 - Fischer, Hakan A1 - Flor, Herta A1 - Gaebler, Michael A1 - Gianaros, Peter J. A1 - Giummarra, Melita J. A1 - Greening, Steven G. A1 - Guendelman, Simon A1 - Heathers, James A. J. A1 - Herpertz, Sabine C. A1 - Hu, Mandy X. A1 - Jentschke, Sebastian A1 - Kaess, Michael A1 - Kaufmann, Tobias A1 - Klimes-Dougan, Bonnie A1 - Koelsch, Stefan A1 - Krauch, Marlene A1 - Kumral, Deniz A1 - Lamers, Femke A1 - Lee, Tae-Ho A1 - Lekander, Mats A1 - Lin, Feng A1 - Lotze, Martin A1 - Makovac, Elena A1 - Mancini, Matteo A1 - Mancke, Falk A1 - Mansson, Kristoffer N. T. A1 - Manuck, Stephen B. A1 - Mather, Mara A1 - Meeten, Frances A1 - Min, Jungwon A1 - Mueller, Bryon A1 - Muench, Vera A1 - Nees, Frauke A1 - Nga, Lin A1 - Nilsonne, Gustav A1 - Ordonez Acuna, Daniela A1 - Osnes, Berge A1 - Ottaviani, Cristina A1 - Penninx, Brenda W. J. H. A1 - Ponzio, Allison A1 - Poudel, Govinda R. A1 - Reinelt, Janis A1 - Ren, Ping A1 - Sakaki, Michiko A1 - Schumann, Andy A1 - Sorensen, Lin A1 - Specht, Karsten A1 - Straub, Joana A1 - Tamm, Sandra A1 - Thai, Michelle A1 - Thayer, Julian F. A1 - Ubani, Benjamin A1 - van Der Mee, Denise J. A1 - van Velzen, Laura S. A1 - Ventura-Bort, Carlos A1 - Villringer, Arno A1 - Watson, David R. A1 - Wei, Luqing A1 - Wendt, Julia A1 - Schreiner, Melinda Westlund A1 - Westlye, Lars T. A1 - Weymar, Mathias A1 - Winkelmann, Tobias A1 - Wu, Guo-Rong A1 - Yoo, Hyun Joo A1 - Quintana, Daniel S. T1 - Cortical thickness and resting-state cardiac function across the lifespan BT - a cross-sectional pooled mega-analysis JF - Psychophysiology : journal of the Society for Psychophysiological Research N2 - Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS-or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research. KW - aging KW - autonomic nervous system KW - cortical thickness KW - heart rate KW - heart KW - rate variability KW - sex Y1 - 2020 U6 - https://doi.org/10.1111/psyp.13688 SN - 0048-5772 SN - 1469-8986 VL - 58 IS - 7 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Kaba, Hani E. J. A1 - Maier, Natalia A1 - Schliebe-Ohler, Nicole A1 - Mayer, Yvonne A1 - Mueller, Peter P. A1 - van den Heuvel, Joop A1 - Schuchhardt, Johannes A1 - Hanack, Katja A1 - Bilitewski, Ursula T1 - Identification of whole pathogenic cells by monoclonal antibodies generated against a specific peptide from an immunogenic cell wall protein JF - Journal of microbiological methods N2 - We selected the immunogenic cell wall beta-(1,3)-glucosyltransferase Bgl2p from Candida albicans as a target protein for the production of antibodies. We identified a unique peptide sequence in the protein and generated monoclonal anti- C. albicans Bgl2p antibodies, which bound in particular to whole C. albicans cells. KW - Candida KW - Diagnostics KW - Flow cytometry KW - Peptides KW - Bgl2p Y1 - 2015 U6 - https://doi.org/10.1016/j.mimet.2014.11.003 SN - 0167-7012 SN - 1872-8359 VL - 108 SP - 61 EP - 69 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Mueller, Carsten A1 - Ullmann, Kristina A1 - Wilkens, Andrea A1 - Winterhalter, Peter A1 - Toyokuni, Shinya A1 - Steinberg, Pablo T1 - Potent antioxidative activity of vineatrol (R) 30 grapevine-shoot extract N2 - The health promoting effects of a grapevine-shoot extract named Vineatrol (R) 30, which contains resveratrol (Resv) as well as considerable amounts of Resv oligomers, have recently been investigated. In the present study, we analyzed the free radical scavenging capacity, the ability to inhibit lipid peroxidation, and the capacity to enhance the human glutathione peroxidase 1 (GPx) and the human superoxide dismutase 1 (SOD) gene promoter activities of Vineatrol (R) 30. Vineatrol (R) 30 was able to scavenge the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical cation and led to concentration-dependent inhibition of lipid peroxidation, Vineatrol (R) 30 not being superior to Resv alone in both cases. Vineatrol (R) 30 also enhanced the gene promoter activities of human GPx and SOD expressed in V79 cells, whereas this effect could not be demonstrated for Resv. In summary, the results presented in this study show that the Vineatrol (R) 30 grapevine-shoot extract is a free radical scavenger and potent antioxidant at non- eytotoxic concentrations. Y1 - 2009 UR - http://www.jstage.jst.go.jp/browse/bbb U6 - https://doi.org/10.1271/Bbb.90213 SN - 0916-8451 ER - TY - GEN A1 - Moser, Othmar A1 - Tschakert, Gerhard A1 - Mueller, Alexander A1 - Groeschl, Werner A1 - Pieber, Thomas R. A1 - Obermayer-Pietsch, Barbara A1 - Koehler, Gerd A1 - Hofmann, Peter T1 - Effects of high-intensity interval exercise versus moderate continuous exercise on glucose homeostasis and hormone response in patients with type 1 diabetes mellitus using novel ultra-long-acting insulin T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Introduction We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM). Material and Methods Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system. Results BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C. Conclusion Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 497 KW - target heart-rate KW - failure KW - recommendations KW - hypoglycemia KW - individuals KW - performance KW - risk Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-408342 SN - 1866-8364 IS - 497 ER - TY - JOUR A1 - Moser, Othmar A1 - Mader, Julia K. A1 - Tschakert, Gerhard A1 - Mueller, Alexander A1 - Groeschl, Werner A1 - Pieber, Thomas R. A1 - Koehler, Gerd A1 - Messerschmidt, Janin A1 - Hofmann, Peter T1 - Accuracy of Continuous Glucose Monitoring (CGM) during Continuous and High-Intensity Interval Exercise in Patients with Type 1 Diabetes Mellitus JF - Nutrients N2 - Continuous exercise (CON) and high-intensity interval exercise (HIIE) can be safely performed with type 1 diabetes mellitus (T1DM). Additionally, continuous glucose monitoring (CGM) systems may serve as a tool to reduce the risk of exercise-induced hypoglycemia. It is unclear if CGM is accurate during CON and HIIE at different mean workloads. Seven T1DM patients performed CON and HIIE at 5% below (L) and above (M) the first lactate turn point (LTP1), and 5% below the second lactate turn point (LTP2) (H) on a cycle ergometer. Glucose was measured via CGM and in capillary blood (BG). Differences were found in comparison of CGM vs. BG in three out of the six tests (p < 0.05). In CON, bias and levels of agreement for L, M, and H were found at: 0.85 (-3.44, 5.15) mmol.L-1, -0.45 (-3.95, 3.05) mmol.L-1, -0.31 (-8.83, 8.20) mmol.L-1 and at 1.17 (-2.06, 4.40) mmol.L-1, 0.11 (-5.79, 6.01) mmol.L-1, 1.48 (-2.60, 5.57) mmol.L-1 in HIIE for the same intensities. Clinically-acceptable results (except for CON H) were found. CGM estimated BG to be clinically acceptable, except for CON H. Additionally, using CGM may increase avoidance of exercise-induced hypoglycemia, but usual BG control should be performed during intense exercise. KW - continuous glucose monitoring KW - exercise KW - diabetes KW - blood glucose Y1 - 2016 U6 - https://doi.org/10.3390/nu8080489 SN - 2072-6643 VL - 8 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wessig, Pablo A1 - Merkel, Roswitha A1 - Mueller, Peter T1 - Articulated rods - a novel class of molecular rods based on oligospiroketals (OSK) JF - Beilstein journal of organic chemistry N2 - We developed a new type of molecular rods consisting of two (or more) rigid units linked by a flexible joint. Consequently we called these constructs articulated rods (ARs). The syntheses of ARs were carried out by a flexible and modular approach providing access to a number of compounds with various functionalizations in terminal positions. First applications were presented with pyrene, cinnamoyl and anthracenyl labelled ARs. KW - articulated rods KW - click chemistry KW - molecular rods KW - oligospiroketals KW - pyrene excimer Y1 - 2015 U6 - https://doi.org/10.3762/bjoc.11.11 SN - 1860-5397 VL - 11 SP - 74 EP - 84 PB - Beilstein-Institut zur Förderung der Chemischen Wissenschaften CY - Frankfurt, Main ER - TY - JOUR A1 - Haralampiev, Ivan A1 - Mertens, Monique A1 - Schwarzer, Roland A1 - Herrmann, Andreas A1 - Volkmer, Rudolf A1 - Wessig, Pablo A1 - Mueller, Peter T1 - Recruitment of SH-Containing peptides to lipid and biological membranes through the use of a palmitic acid functionalized with a Maleimide Group JF - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition N2 - This study presents a novel and easily applicable approach to recruit sulfhydryl-containing biomolecules to membranes by using a palmitic acid which is functionalized with a maleimide group. Notably, this strategy can also be employed with preformed (biological) membranes. The applicability of the assay is demonstrated by characterizing the binding of a Rhodamine-labeled peptide to lipid and cellular membranes using methods of fluorescence spectroscopy, lifetime measurement, and microscopy. Our approach offers new possibilities for preparing biologically active liposomes and manipulating living cells. KW - liposomes KW - maleimide KW - membranes KW - palmitic acid KW - palmitoylation KW - peptides Y1 - 2015 U6 - https://doi.org/10.1002/anie.201408089 SN - 1433-7851 SN - 1521-3773 VL - 54 IS - 1 SP - 323 EP - 326 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Tschakert, Gerhard A1 - Kroepfl, Julia A1 - Mueller, Alexander A1 - Moser, Othmar A1 - Groeschl, Werner A1 - Hofmann, Peter T1 - How to Regulate the Acute Physiological Response to "Aerobic" High-Intensity Interval Exercise JF - Journal of sports science & medicine N2 - The acute physiological processes during "aerobic" high-intensity interval exercise (HIIE) and their regulation are inadequately studied. The main goal of this study was to investigate the acute metabolic and cardiorespiratory response to long and short HIIE compared to continuous exercise (CE) as well as its regulation and predictability. Six healthy well-trained sport students (5 males, 1 female; age: 25.7 +/- 3.1 years; height: 1.80 +/- 0.04 m; weight: 76.7 +/- 6.4 kg; VO2max: 4.33 +/- 0.7 l.min(-1)) performed a maximal incremental exercise test (IET) and subsequently three different exercise sessions matched for mean load (P-mean) and exercise duration (28 min): 1) long HIIE with submaximal peak workloads (P-peak = power output at 95 % of maximum heart rate), peak workload durations (t(peak)) of 4 min, and recovery durations (t(rec)) of 3 min, 2) short HIIE with P-peak according to the maximum power output (P-max) from IET, t(peak) of 20 s, and individually calculated t(rec) (26.7 +/- 13.4 s), and 3) CE with a target workload (P-target) equating to P-mean of HIIE. In short HIIE, mean lactate (La-mean) (5.22 +/- 1.41 mmol.l(-1)), peak La (7.14 +/- 2.48 mmol.l(-1)), and peak heart rate (HRpeak) (181.00 +/- 6.66 b.min(-1)) were significantly lower compared to long HIIE (La-mean: 9.83 +/- 2.78 mmol.l(-1); La-peak: 12.37 +/- 4.17 mmol.l(-1), HRpeak: 187.67 +/- 5.72 b.min(-1)). No significant differences in any parameters were found between short HIIE and CE despite considerably higher peak workloads in short HIIE. The acute metabolic and peak cardiorespiratory demand during "aerobic" short HIIE was significantly lower compared to long HIIE and regulable via Pmean. Consequently, short HIIE allows a consciously aimed triggering of specific and desired or required acute physiological responses. KW - Intermittent exercise KW - exercise prescription KW - acute physiological demand KW - mean load KW - peak workload duration Y1 - 2015 SN - 1303-2968 VL - 14 IS - 1 SP - 29 EP - 36 PB - Department of Sports Medicine, Medical Faculty of Uludag University CY - Bursa ER - TY - GEN A1 - Moser, Othmar A1 - Mader, Julia K. A1 - Tschakert, Gerhard A1 - Mueller, Alexander A1 - Groeschl, Werner A1 - Pieber, Thomas R. A1 - Koehler, Gerd A1 - Messerschmidt, Janin A1 - Hofmann, Peter T1 - Accuracy of Continuous Glucose Monitoring (CGM) during continuous and high-intensity interval exercise in patients with Type 1 Diabetes Mellitus N2 - Continuous exercise (CON) and high-intensity interval exercise (HIIE) can be safely performed with type 1 diabetes mellitus (T1DM). Additionally, continuous glucose monitoring (CGM) systems may serve as a tool to reduce the risk of exercise-induced hypoglycemia. It is unclear if CGM is accurate during CON and HIIE at different mean workloads. Seven T1DM patients performed CON and HIIE at 5% below (L) and above (M) the first lactate turn point (LTP1), and 5% below the second lactate turn point (LTP2) (H) on a cycle ergometer. Glucose was measured via CGM and in capillary blood (BG). Differences were found in comparison of CGM vs. BG in three out of the six tests (p < 0.05). In CON, bias and levels of agreement for L, M, and H were found at: 0.85 (−3.44, 5.15) mmol·L−1, −0.45 (−3.95, 3.05) mmol·L−1, −0.31 (−8.83, 8.20) mmol·L−1 and at 1.17 (−2.06, 4.40) mmol·L−1, 0.11 (−5.79, 6.01) mmol·L−1, 1.48 (−2.60, 5.57) mmol·L−1 in HIIE for the same intensities. Clinically-acceptable results (except for CON H) were found. CGM estimated BG to be clinically acceptable, except for CON H. Additionally, using CGM may increase avoidance of exercise-induced hypoglycemia, but usual BG control should be performed during intense exercise. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 338 KW - continuous glucose monitoring KW - exercise KW - diabetes KW - blood glucose Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-400470 ER - TY - GEN A1 - Moser, Othmar A1 - Mueller, Alexander A1 - Tschakert, Gerhard A1 - Koehler, Gerd A1 - Lawrence, Jimmy B. A1 - Groeschl, Werner A1 - Pieber, Thomas R. A1 - Bracken, Richard M. A1 - Hofmann, Peter T1 - Exercise Prescription in Type 1 Diabetes: Should We Use Percentages of Maximum Heart Rate? T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine Y1 - 2017 U6 - https://doi.org/10.1249/01.mss.0000519798.35679.cf SN - 0195-9131 SN - 1530-0315 VL - 49 SP - 1020 EP - 1020 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Bzymek, Robert A1 - Horsthemke, Markus A1 - Isfort, Katrin A1 - Mohr, Simon A1 - Tjaden, Kerstin A1 - Mueller-Tidow, Carsten A1 - Thomann, Marlies A1 - Schwerdtle, Tanja A1 - Baehler, Martin A1 - Schwab, Albrecht A1 - Hanley, Peter J. T1 - Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho JF - Scientific reports N2 - We recently found that macrophages from RhoA/RhoB double knockout mice had increased motility of the cell body, but severely impaired retraction of the tail and membrane extensions, whereas RhoA-or RhoB-deficient cells exhibited mild phenotypes. Here we extended this work and investigated the roles of Rho signaling in primary human blood monocytes migrating in chemotactic gradients and in various settings. Monocyte velocity, but not chemotactic navigation, was modestly dependent on Rho-ROCK-myosin II signaling on a 2D substrate or in a loose collagen type I matrix. Viewed by time-lapse epi-fluorescence microscopy, monocytes appeared to flutter rather than crawl, such that the 3D surface topology of individual cells was difficult to predict. Spinning disk confocal microscopy and 3D reconstruction revealed that cells move on planar surfaces and in a loose collagen matrix using prominent, curved planar protrusions, which are rapidly remodeled and reoriented, as well as resorbed. In a dense collagen type I matrix, there is insufficient space for this mode and cells adopt a highly Rho-dependent, lobular mode of motility. Thus, in addition to its role in tail retraction on 2D surfaces, Rho is critical for movement in confined spaces, but is largely redundant for motility and chemotaxis in loose matrices. Y1 - 2016 U6 - https://doi.org/10.1038/srep25016 SN - 2045-2322 VL - 6 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Heger, Tina A1 - Bernard-Verdier, Maud A1 - Gessler, Arthur A1 - Greenwood, Alex D. A1 - Grossart, Hans-Peter A1 - Hilker, Monika A1 - Keinath, Silvia A1 - Kowarik, Ingo A1 - Küffer, Christoph A1 - Marquard, Elisabeth A1 - Mueller, Johannes A1 - Niemeier, Stephanie A1 - Onandia, Gabriela A1 - Petermann, Jana S. A1 - Rillig, Matthias C. A1 - Rodel, Mark-Oliver A1 - Saul, Wolf-Christian A1 - Schittko, Conrad A1 - Tockner, Klement A1 - Joshi, Jasmin Radha A1 - Jeschke, Jonathan M. T1 - Towards an Integrative, Eco-Evolutionary Understanding of Ecological Novelty: Studying and Communicating Interlinked Effects of Global Change JF - Bioscience N2 - Global change has complex eco-evolutionary consequences for organisms and ecosystems, but related concepts (e.g., novel ecosystems) do not cover their full range. Here we propose an umbrella concept of "ecological novelty" comprising (1) a site-specific and (2) an organism-centered, eco-evolutionary perspective. Under this umbrella, complementary options for studying and communicating effects of global change on organisms, ecosystems, and landscapes can be included in a toolbox. This allows researchers to address ecological novelty from different perspectives, e.g., by defining it based on (a) categorical or continuous measures, (b) reference conditions related to sites or organisms, and (c) types of human activities. We suggest striving for a descriptive, non-normative usage of the term "ecological novelty" in science. Normative evaluations and decisions about conservation policies or management are important, but require additional societal processes and engagement with multiple stakeholders. KW - Anthropocene KW - eco-evolutionary experience KW - global change KW - novel ecosystems KW - shifting baselines Y1 - 2019 U6 - https://doi.org/10.1093/biosci/biz095 SN - 0006-3568 SN - 1525-3244 VL - 69 IS - 11 SP - 888 EP - 899 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Soliveres, Santiago A1 - Manning, Peter A1 - Prati, Daniel A1 - Gossner, Martin M. A1 - Alt, Fabian A1 - Arndt, Hartmut A1 - Baumgartner, Vanessa A1 - Binkenstein, Julia A1 - Birkhofer, Klaus A1 - Blaser, Stefan A1 - Bluethgen, Nico A1 - Boch, Steffen A1 - Boehm, Stefan A1 - Boerschig, Carmen A1 - Buscot, Francois A1 - Diekoetter, Tim A1 - Heinze, Johannes A1 - Hoelzel, Norbert A1 - Jung, Kirsten A1 - Klaus, Valentin H. A1 - Klein, Alexandra-Maria A1 - Kleinebecker, Till A1 - Klemmer, Sandra A1 - Krauss, Jochen A1 - Lange, Markus A1 - Morris, E. Kathryn A1 - Mueller, Joerg A1 - Oelmann, Yvonne A1 - Overmann, Jörg A1 - Pasalic, Esther A1 - Renner, Swen C. A1 - Rillig, Matthias C. A1 - Schaefer, H. Martin A1 - Schloter, Michael A1 - Schmitt, Barbara A1 - Schoening, Ingo A1 - Schrumpf, Marion A1 - Sikorski, Johannes A1 - Socher, Stephanie A. A1 - Solly, Emily F. A1 - Sonnemann, Ilja A1 - Sorkau, Elisabeth A1 - Steckel, Juliane A1 - Steffan-Dewenter, Ingolf A1 - Stempfhuber, Barbara A1 - Tschapka, Marco A1 - Tuerke, Manfred A1 - Venter, Paul A1 - Weiner, Christiane N. A1 - Weisser, Wolfgang W. A1 - Werner, Michael A1 - Westphal, Catrin A1 - Wilcke, Wolfgang A1 - Wolters, Volkmar A1 - Wubet, Tesfaye A1 - Wurst, Susanne A1 - Fischer, Markus A1 - Allan, Eric T1 - Locally rare species influence grassland ecosystem multifunctionality JF - Philosophical transactions of the Royal Society of London : B, Biological sciences N2 - Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land use intensity (LUI) gradient. The diversity of above- and below-ground rare species had opposite effects, with rare above-ground species being associated with high levels of multifunctionality, probably because their effects on different functions did not trade off against each other. Conversely, common species were only related to average, not high, levels of multifunctionality, and their functional effects declined with LUI. Apart from the community level effects of diversity, we found significant positive associations between the abundance of individual species and multifunctionality in 6% of the species tested. Species specific functional effects were best predicted by their response to LUI: species that declined in abundance with land use intensification were those associated with higher levels of multifunctionality. Our results highlight the importance of rare species for ecosystem multifunctionality and help guiding future conservation priorities. KW - biodiversity KW - common species KW - ecosystem function KW - identity hypothesis KW - land use KW - multitrophic Y1 - 2016 U6 - https://doi.org/10.1098/rstb.2015.0269 SN - 0962-8436 SN - 1471-2970 VL - 371 SP - 3175 EP - 3185 PB - Royal Society CY - London ER -