TY  - JOUR
A1  - Peters, Jörg
A1  - Gilles, Peter
A1  - Auer, Peter
A1  - Selting, Margret
T1  - Identifying regional varieties by pitch information : a comparison of two approaches
Y1  - 2003
SN  - 1-87634-649-3
ER  - 
TY  - JOUR
A1  - Selting, Margret
A1  - Auer, Peter
A1  - Barden, Birgit
A1  - Bergmann, Jörg
A1  - Couper-Kuhlen, Elizabeth
A1  - Günthner, Susanne
A1  - Quasthoff, Uta
A1  - Meier, Christoph
A1  - Schlobinski, Peter
A1  - Uhmann, Susanne
T1  - Gesprächsanalytisches Transkriptionssystem (GAT)
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Selting, Margret
A1  - Auer, Peter
A1  - Barth-Weingarten, Dagmar
A1  - Bergmann, Jörg
A1  - Bergmann, Pia
A1  - Birkner, Karin
A1  - Couper-Kuhlen, Elizabeth
A1  - Deppermann, Arnulf
A1  - Gilles, Peter
A1  - Günthner, Susanne
A1  - Hartung, Martin
A1  - Kern, Friederike
A1  - Mertzlufft, Christine
A1  - Meyer, Christian
A1  - Morek, Miriam
A1  - Oberzaucher, Frank
A1  - Peters, Jörg
A1  - Quasthoff, Uta
A1  - Schütte, Wilfried
A1  - Stukenbrock, Anja
A1  - Uhmann, Susanne
T1  - Gesprächsanalytisches Transkriptionssystem 2 (GAT 2)
Y1  - 2009
UR  - http://www.gespraechsforschung-ozs.de/heft2009/px-gat2.pdf (12.9.13)
SN  - 1617-1837
ER  - 
TY  - JOUR
A1  - Peters, Jörg
A1  - Gilles, Peter
A1  - Auer, Peter
A1  - Selting, Margret
T1  - Identification of regional varieties by intonational cues : an experimental study on Hamburg and Berlin German
Y1  - 2002
ER  - 
TY  - JOUR
A1  - Selting, Margret
A1  - Auer, Peter
A1  - Gilles, Peter
A1  - Peters, Jörg
T1  - Intonation regionaler Varietäten des Deutschen : Vorstellung eines Forschungsprojekts
Y1  - 2000
SN  - 3-515-07762-6
ER  - 
TY  - JOUR
A1  - Selting, Margret
A1  - Auer, Peter
T1  - Der Beitrag der Prosodie zur Gesprächsorganisation
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Galhuber, Markus
A1  - Michenthaler, Helene
A1  - Heininger, Christoph
A1  - Reinisch, Isabel
A1  - Nössing, Christoph
A1  - Krstic, Jelena
A1  - Kupper, Nadja
A1  - Moyschewitz, Elisabeth
A1  - Auer, Martina
A1  - Heitzer, Ellen
A1  - Ulz, Peter
A1  - Birner-Gruenberger, Ruth
A1  - Liesinger, Laura
A1  - Lenihan-Geels, Georgia Ngawai
A1  - Oster, Moritz
A1  - Spreitzer, Emil
A1  - Chiozzi, Riccardo Zenezini
A1  - Schulz, Tim J.
A1  - Schupp, Michael
A1  - Madl, Tobias
A1  - Heck, Albert J. R.
A1  - Prokesch, Andreas
T1  - Complementary omics strategies to dissect p53 signaling networks under nutrient stress
JF  - Cellular and molecular life sciences
N2  - Signaling trough p53is a major cellular stress response mechanism and increases upon nutrient stresses such as starvation. Here, we show in a human hepatoma cell line that starvation leads to robust nuclear p53 stabilization. Using BioID, we determine the cytoplasmic p53 interaction network within the immediate-early starvation response and show that p53 is dissociated from several metabolic enzymes and the kinase PAK2 for which direct binding with the p53 DNA-binding domain was confirmed with NMR studies. Furthermore, proteomics after p53 immunoprecipitation (RIME) uncovered the nuclear interactome under prolonged starvation, where we confirmed the novel p53 interactors SORBS1 (insulin receptor signaling) and UGP2 (glycogen synthesis). Finally, transcriptomics after p53 re-expression revealed a distinct starvation-specific transcriptome response and suggested previously unknown nutrient-dependent p53 target genes. Together, our complementary approaches delineate several nodes of the p53 signaling cascade upon starvation, shedding new light on the mechanisms of p53 as nutrient stress sensor. Given the central role of p53 in cancer biology and the beneficial effects of fasting in cancer treatment, the identified interaction partners and networks could pinpoint novel pharmacologic targets to fine-tune p53 activity.
KW  - p53 signaling
KW  - Nutrient stress
KW  - Starvation
KW  - Interactome
KW  - p53 targets
Y1  - 2022
U6  - https://doi.org/10.1007/s00018-022-04345-8
SN  - 1420-682X
SN  - 1420-9071
VL  - 79
IS  - 6
PB  - Springer Nature
CY  - Basel
ER  -