TY  - JOUR
A1  - Gancheva, Sofiya
A1  - Ouni, Meriem
A1  - Jelenik, Tomas
A1  - Koliaki, Chrysi
A1  - Szendroedi, Julia
A1  - Toledo, Frederico G. S.
A1  - Markgraf, Daniel Frank
A1  - Pesta, Dominik H.
A1  - Mastrototaro, Lucia
A1  - De Filippo, Elisabetta
A1  - Herder, Christian
A1  - Jähnert, Markus
A1  - Weiss, Jürgen
A1  - Strassburger, Klaus
A1  - Schlensak, Matthias
A1  - Schürmann, Annette
A1  - Roden, Michael
T1  - Dynamic changes of muscle insulin sensitivity after metabolic surgery
JF  - Nature Communications
N2  - The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity.
Y1  - 2019
U6  - https://doi.org/10.1038/s41467-019-12081-0
SN  - 2041-1723
VL  - 10
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Neuschaefer-Rube, Frank
A1  - Lieske, Stefanie
A1  - Kuna, Manuela
A1  - Henkel, Janin
A1  - Perry, Rachel J.
A1  - Erion, Derek M.
A1  - Pesta, Dominik
A1  - Willmes, Diana M.
A1  - Brachs, Sebastian
A1  - von Loeffelholz, Christian
A1  - Tolkachov, Alexander
A1  - Schupp, Michael
A1  - Pathe-Neuschaefer-Rube, Andrea
A1  - Pfeiffer, Andreas F. H.
A1  - Shulman, Gerald I.
A1  - Püschel, Gerhard Paul
A1  - Birkenfeld, Andreas L.
T1  - The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes
JF  - Diabetes : a journal of the American Diabetes Association
Y1  - 2014
SN  - 0012-1797
SN  - 1939-327X
VL  - 63
IS  - 3
SP  - 1048
EP  - 1057
PB  - American Diabetes Association
CY  - Alexandria
ER  -