TY  - JOUR
A1  - Schmidt, Bernd
A1  - Nave, Stefan
T1  - Stereoselective syntheses of enantiomerically pure 2,5-disubstituted dihydropyrans based on olefin metathesis
JF  - The journal of organic chemistry
N2  - A short synthesis of 2,5-disubstituted dihydropyrans starting from D-mannitol as a chiral building block is described. Our synthetic approach combines ruthenium-catalyzed ring closing olefin metathesis and palladium-catalyzed nucleophilic substitution.
Y1  - 2006
U6  - https://doi.org/10.1021/jo061190k
SN  - 0022-3263
VL  - 71
IS  - 19
SP  - 7364
EP  - 7369
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Flöel, Agnes
A1  - Werner, Cordula
A1  - Grittner, Ulrike
A1  - Hesse, Stefan
A1  - Jöbges, Michael
A1  - Knauss, Janet
A1  - Seifert, Michael
A1  - Steinhagen-Thiessen, Elisabeth
A1  - Goevercin, Mehmet
A1  - Dohle, Christian
A1  - Fischer, Wolfgang
A1  - Schlieder, Regina
A1  - Nave, Alexander Heinrich
A1  - Meisel, Andreas
A1  - Ebinger, Martin
A1  - Wellwood, Ian
T1  - Physical fitness training in Subacute Stroke (PHYS-STROKE) - study protocol for a randomised controlled trial
JF  - Trials
N2  - Background: 
Given the rising number of strokes worldwide, and the large number of individuals left with disabilities after stroke, novel strategies to reduce disability, increase functions in the motor and the cognitive domains, and improve quality of life are of major importance. Physical activity is a promising intervention to address these challenges but, as yet, there is no study demonstrating definite outcomes. Our objective is to assess whether additional treatment in the form of physical fitness-based training for patients early after stroke will provide benefits in terms of functional outcomes, in particular gait speed and the Barthel Index (co-primary outcome measures) reflecting activities of daily living (ADL). We will gather secondary functional outcomes as well as mechanistic parameters in an exploratory approach.
 Methods/Design: Our phase III randomised controlled trial will recruit 215 adults with moderate to severe limitations of walking and ADL 5 to 45 days after stroke onset. Participants will be stratified for the prognostic variables of "centre", "age", and "stroke severity", and randomly assigned to one of two groups. The interventional group receives physical fitness training delivered as supported or unsupported treadmill training (cardiovascular active aerobic training; five times per week, over 4 weeks; each session 50 minutes; total of 20 additional physical fitness training sessions) in addition to standard rehabilitation treatment. The control intervention consists of relaxation sessions (non-cardiovascular active; five times per week week, over 4 weeks; each session 50 minutes) in addition to standard rehabilitation treatment. Co-primary efficacy endpoints will be gait speed (in m/s, 10 m walk) and the Barthel Index (100 points total) at 3 months post-stroke, compared to baseline measurements. Secondary outcomes include standard measures of quality of life, sleep and mood, cognition, arm function, maximal oxygen uptake, and cardiovascular risk factors including blood pressure, pulse, waist-to-hip ratio, markers of inflammation, immunity and the insulin-glucose pathway, lipid profile, and others.
 Discussion: The goal of this endpoint-blinded, phase III randomised controlled trial is to provide evidence to guide post-stroke physical fitness-based rehabilitation programmes, and to elucidate the mechanisms underlying this intervention.
Y1  - 2014
U6  - https://doi.org/10.1186/1745-6215-15-45
SN  - 1745-6215
VL  - 15
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Schmidt, Bernd
A1  - Nave, Stefan
T1  - Control of ring size selectivity by substrate directable RCM
N2  - Hydroxy groups may exert strong catalyst-directing effects in olefin metathesis reactions, which are exploited for a ring size-selective RCM reaction
Y1  - 2006
UR  - http://pubs.rsc.org/en/content/articlehtml/2006/cc/b604359c
U6  - https://doi.org/10.1039/B604359c
ER  - 
TY  - JOUR
A1  - Schmidt, Bernd
A1  - Nave, Stefan
T1  - Palladium-catalyzed O-allylation of alpha-hydroxy carbonyl compounds
N2  - alpha-Hydroxy carbonyl compounds undergo smooth O-allylation using allylic carbonates and Pd(0) catalysts. This method has significant advantages over other O-allylation methods as it provides a solution to several problems previously observed for this synthetic transformation
Y1  - 2006
UR  - http://onlinelibrary.wiley.com/doi/10.1002/adsc.200505361/pdf
U6  - https://doi.org/10.1002/adsc.200505361
ER  -