TY  - JOUR
A1  - Nickerson, David
A1  - Atalag, Koray
A1  - de Bono, Bernard
A1  - Geiger, Joerg
A1  - Goble, Carole
A1  - Hollmann, Susanne
A1  - Lonien, Joachim
A1  - Mueller, Wolfgang
A1  - Regierer, Babette
A1  - Stanford, Natalie J.
A1  - Golebiewski, Martin
A1  - Hunter, Peter
T1  - The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable
JF  - Interface focus
N2  - Reconstructing and understanding the Human Physiome virtually is a complex mathematical problem, and a highly demanding computational challenge. Mathematical models spanning from the molecular level through to whole populations of individuals must be integrated, then personalized. This requires interoperability with multiple disparate and geographically separated data sources, and myriad computational software tools. Extracting and producing knowledge from such sources, even when the databases and software are readily available, is a challenging task. Despite the difficulties, researchers must frequently perform these tasks so that available knowledge can be continually integrated into the common framework required to realize the Human Physiome. Software and infrastructures that support the communities that generate these, together with their underlying standards to format, describe and interlink the corresponding data and computer models, are pivotal to the Human Physiome being realized. They provide the foundations for integrating, exchanging and re-using data and models efficiently, and correctly, while also supporting the dissemination of growing knowledge in these forms. In this paper, we explore the standards, software tooling, repositories and infrastructures that support this work, and detail what makes them vital to realizing the Human Physiome.
KW  - Human Physiome
KW  - standards
KW  - repositories
KW  - service infrastructure
KW  - reproducible science
KW  - managing big data
Y1  - 2016
U6  - https://doi.org/10.1098/rsfs.2015.0103
SN  - 2042-8898
SN  - 2042-8901
VL  - 6
SP  - 57
EP  - 61
PB  - Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Wengenmayer, Christina
A1  - Krikov, Maxim
A1  - Mueller, Susanne
A1  - Lucht, Kristin
A1  - Villringer, Arno
A1  - Hocher, Berthold
A1  - Unger, Thomas
A1  - Thoene-Reineke, Christa
T1  - Novel therapy approach in primary stroke prevention simultaneous inhibition of endothelin converting enzyme and neutral endopeptidase in spontaneously hypertensive, stroke-prone rats improves survival
JF  - Neurological research : a journal of progress in neurosurgery and neurosciences
N2  - Objectives: Stroke, frequently a consequence of hypertension, is one of the leading causes of death and neurological disabilities worldwide. In the ischemic brain, levels of endothelin-1, one of the most potent vasoconstrictors, are raised. Anti-inflammatory and neuroprotective effects of endothelin antagonists after stroke have been described in literature. Based on these findings, we investigated the protective effect of the endothelin converting enzyme/neutral endopeptidase blocker, SLV 338, in salt-loaded, stroke-prone, spontaneously hypertensive rats.
 Methods: Male, 8-week-old spontaneously hypertensive stroke-prone rats were put on a high salt diet and treated with either 30 mg/kg or 100 mg/kg SLV 338 or vehicle for 27 weeks. Blood pressure, neurological outcome, body weight, and mortality were investigated throughout treatment. In weeks 1 and 9, animals were housed in metabolic cages for collection of urinary and blood samples and assessment of salt water and food intake. In weeks 22 and 27, additional blood samples were taken. At the end of the study, all brains were analyzed using magnetic resonance imaging.
 Results: SLV 338 was well tolerated in all animals. Neurological outcome and infarct size were similar in all groups. Albuminuria was considerably delayed and the incidence of stroke significantly lowered in treated animals. In spontaneously hypertensive stroke-prone rats, treatment with SLV 338 significantly (P=0.01) improved survival in comparison to the vehicle treated group in a blood pressure-independent manner.
 Discussion: Our data in spontaneously hypertensive stroke-prone rats demonstrate that combined endothelin converting enzyme/neutral endopeptidase inhibition could offer a new therapeutic approach for primary stroke prevention and improvement of mortality. The mechanism seems to be blood pressure-independent.
KW  - Endothelin
KW  - Hypertension
KW  - Natriuretic peptides
KW  - Stroke
Y1  - 2011
U6  - https://doi.org/10.1179/016164111X12881719352534
SN  - 0161-6412
VL  - 33
IS  - 2
SP  - 201
EP  - 207
PB  - Routledge, Taylor & Francis Group
CY  - Leeds
ER  - 
TY  - JOUR
A1  - Hilker, Monika
A1  - Schwachtje, Jens
A1  - Baier, Margarete
A1  - Balazadeh, Salma
A1  - Bäurle, Isabel
A1  - Geiselhardt, Sven
A1  - Hincha, Dirk K.
A1  - Kunze, Reinhard
A1  - Mueller-Roeber, Bernd
A1  - Rillig, Matthias G.
A1  - Rolff, Jens
A1  - Schmülling, Thomas
A1  - Steppuhn, Anke
A1  - van Dongen, Joost
A1  - Whitcomb, Sarah J.
A1  - Wurst, Susanne
A1  - Zuther, Ellen
A1  - Kopka, Joachim
T1  - Priming and memory of stress responses in organisms lacking a nervous system
JF  - Biological reviews
KW  - priming
KW  - stress signalling
KW  - epigenetics
KW  - memory
KW  - fitness
KW  - stress tolerance
KW  - defence
KW  - bet hedging
Y1  - 2016
U6  - https://doi.org/10.1111/brv.12215
SN  - 1464-7931
SN  - 1469-185X
VL  - 91
SP  - 1118
EP  - 1133
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Tucker, Marlee A.
A1  - Boehning-Gaese, Katrin
A1  - Fagan, William F.
A1  - Fryxell, John M.
A1  - Van Moorter, Bram
A1  - Alberts, Susan C.
A1  - Ali, Abdullahi H.
A1  - Allen, Andrew M.
A1  - Attias, Nina
A1  - Avgar, Tal
A1  - Bartlam-Brooks, Hattie
A1  - Bayarbaatar, Buuveibaatar
A1  - Belant, Jerrold L.
A1  - Bertassoni, Alessandra
A1  - Beyer, Dean
A1  - Bidner, Laura
A1  - van Beest, Floris M.
A1  - Blake, Stephen
A1  - Blaum, Niels
A1  - Bracis, Chloe
A1  - Brown, Danielle
A1  - de Bruyn, P. J. Nico
A1  - Cagnacci, Francesca
A1  - Calabrese, Justin M.
A1  - Camilo-Alves, Constanca
A1  - Chamaille-Jammes, Simon
A1  - Chiaradia, Andre
A1  - Davidson, Sarah C.
A1  - Dennis, Todd
A1  - DeStefano, Stephen
A1  - Diefenbach, Duane
A1  - Douglas-Hamilton, Iain
A1  - Fennessy, Julian
A1  - Fichtel, Claudia
A1  - Fiedler, Wolfgang
A1  - Fischer, Christina
A1  - Fischhoff, Ilya
A1  - Fleming, Christen H.
A1  - Ford, Adam T.
A1  - Fritz, Susanne A.
A1  - Gehr, Benedikt
A1  - Goheen, Jacob R.
A1  - Gurarie, Eliezer
A1  - Hebblewhite, Mark
A1  - Heurich, Marco
A1  - Hewison, A. J. Mark
A1  - Hof, Christian
A1  - Hurme, Edward
A1  - Isbell, Lynne A.
A1  - Janssen, Rene
A1  - Jeltsch, Florian
A1  - Kaczensky, Petra
A1  - Kane, Adam
A1  - Kappeler, Peter M.
A1  - Kauffman, Matthew
A1  - Kays, Roland
A1  - Kimuyu, Duncan
A1  - Koch, Flavia
A1  - Kranstauber, Bart
A1  - LaPoint, Scott
A1  - Leimgruber, Peter
A1  - Linnell, John D. C.
A1  - Lopez-Lopez, Pascual
A1  - Markham, A. Catherine
A1  - Mattisson, Jenny
A1  - Medici, Emilia Patricia
A1  - Mellone, Ugo
A1  - Merrill, Evelyn
A1  - Mourao, Guilherme de Miranda
A1  - Morato, Ronaldo G.
A1  - Morellet, Nicolas
A1  - Morrison, Thomas A.
A1  - Diaz-Munoz, Samuel L.
A1  - Mysterud, Atle
A1  - Nandintsetseg, Dejid
A1  - Nathan, Ran
A1  - Niamir, Aidin
A1  - Odden, John
A1  - Oliveira-Santos, Luiz Gustavo R.
A1  - Olson, Kirk A.
A1  - Patterson, Bruce D.
A1  - de Paula, Rogerio Cunha
A1  - Pedrotti, Luca
A1  - Reineking, Bjorn
A1  - Rimmler, Martin
A1  - Rogers, Tracey L.
A1  - Rolandsen, Christer Moe
A1  - Rosenberry, Christopher S.
A1  - Rubenstein, Daniel I.
A1  - Safi, Kamran
A1  - Said, Sonia
A1  - Sapir, Nir
A1  - Sawyer, Hall
A1  - Schmidt, Niels Martin
A1  - Selva, Nuria
A1  - Sergiel, Agnieszka
A1  - Shiilegdamba, Enkhtuvshin
A1  - Silva, Joao Paulo
A1  - Singh, Navinder
A1  - Solberg, Erling J.
A1  - Spiegel, Orr
A1  - Strand, Olav
A1  - Sundaresan, Siva
A1  - Ullmann, Wiebke
A1  - Voigt, Ulrich
A1  - Wall, Jake
A1  - Wattles, David
A1  - Wikelski, Martin
A1  - Wilmers, Christopher C.
A1  - Wilson, John W.
A1  - Wittemyer, George
A1  - Zieba, Filip
A1  - Zwijacz-Kozica, Tomasz
A1  - Mueller, Thomas
T1  - Moving in the Anthropocene
BT  - global reductions in terrestrial mammalian movements
JF  - Science
N2  - Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.
Y1  - 2018
U6  - https://doi.org/10.1126/science.aam9712
SN  - 0036-8075
SN  - 1095-9203
VL  - 359
IS  - 6374
SP  - 466
EP  - 469
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Bluethgen, Nico
A1  - Boch, Steffen
A1  - Boehm, Stefan
A1  - Boerschig, Carmen
A1  - Buscot, Francois
A1  - Diekoetter, Tim
A1  - Heinze, Johannes
A1  - Hoelzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Klein, Alexandra-Maria
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Mueller, Joerg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Renner, Swen C.
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schoening, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Tuerke, Manfred
A1  - Venter, Paul
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Locally rare species influence grassland ecosystem multifunctionality
JF  - Philosophical transactions of the Royal Society of London : B, Biological sciences
N2  - Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land use intensity (LUI) gradient. The diversity of above- and below-ground rare species had opposite effects, with rare above-ground species being associated with high levels of multifunctionality, probably because their effects on different functions did not trade off against each other. Conversely, common species were only related to average, not high, levels of multifunctionality, and their functional effects declined with LUI. Apart from the community level effects of diversity, we found significant positive associations between the abundance of individual species and multifunctionality in 6% of the species tested. Species specific functional effects were best predicted by their response to LUI: species that declined in abundance with land use intensification were those associated with higher levels of multifunctionality. Our results highlight the importance of rare species for ecosystem multifunctionality and help guiding future conservation priorities.
KW  - biodiversity
KW  - common species
KW  - ecosystem function
KW  - identity hypothesis
KW  - land use
KW  - multitrophic
Y1  - 2016
U6  - https://doi.org/10.1098/rstb.2015.0269
SN  - 0962-8436
SN  - 1471-2970
VL  - 371
SP  - 3175
EP  - 3185
PB  - Royal Society
CY  - London
ER  -