TY - JOUR
A1 - Middeldorp, Christel M.
A1 - Mahajan, Anubha
A1 - Horikoshi, Momoko
A1 - Robertson, Neil R.
A1 - Beaumont, Robin N.
A1 - Bradfield, Jonathan P.
A1 - Bustamante, Mariona
A1 - Cousminer, Diana L.
A1 - Day, Felix R.
A1 - De Silva, N. Maneka
A1 - Guxens, Monica
A1 - Mook-Kanamori, Dennis O.
A1 - St Pourcain, Beate
A1 - Warrington, Nicole M.
A1 - Adair, Linda S.
A1 - Ahlqvist, Emma
A1 - Ahluwalia, Tarunveer Singh
A1 - Almgren, Peter
A1 - Ang, Wei
A1 - Atalay, Mustafa
A1 - Auvinen, Juha
A1 - Bartels, Meike
A1 - Beckmann, Jacques S.
A1 - Bilbao, Jose Ramon
A1 - Bond, Tom
A1 - Borja, Judith B.
A1 - Cavadino, Alana
A1 - Charoen, Pimphen
A1 - Chen, Zhanghua
A1 - Coin, Lachlan
A1 - Cooper, Cyrus
A1 - Curtin, John A.
A1 - Custovic, Adnan
A1 - Das, Shikta
A1 - Davies, Gareth E.
A1 - Dedoussis, George V.
A1 - Duijts, Liesbeth
A1 - Eastwood, Peter R.
A1 - Eliasen, Anders U.
A1 - Elliott, Paul
A1 - Eriksson, Johan G.
A1 - Estivill, Xavier
A1 - Fadista, Joao
A1 - Fedko, Iryna O.
A1 - Frayling, Timothy M.
A1 - Gaillard, Romy
A1 - Gauderman, W. James
A1 - Geller, Frank
A1 - Gilliland, Frank
A1 - Gilsanz, Vincente
A1 - Granell, Raquel
A1 - Grarup, Niels
A1 - Groop, Leif
A1 - Hadley, Dexter
A1 - Hakonarson, Hakon
A1 - Hansen, Torben
A1 - Hartman, Catharina A.
A1 - Hattersley, Andrew T.
A1 - Hayes, M. Geoffrey
A1 - Hebebrand, Johannes
A1 - Heinrich, Joachim
A1 - Helgeland, Oyvind
A1 - Henders, Anjali K.
A1 - Henderson, John
A1 - Henriksen, Tine B.
A1 - Hirschhorn, Joel N.
A1 - Hivert, Marie-France
A1 - Hocher, Berthold
A1 - Holloway, John W.
A1 - Holt, Patrick
A1 - Hottenga, Jouke-Jan
A1 - Hypponen, Elina
A1 - Iniguez, Carmen
A1 - Johansson, Stefan
A1 - Jugessur, Astanand
A1 - Kahonen, Mika
A1 - Kalkwarf, Heidi J.
A1 - Kaprio, Jaakko
A1 - Karhunen, Ville
A1 - Kemp, John P.
A1 - Kerkhof, Marjan
A1 - Koppelman, Gerard H.
A1 - Korner, Antje
A1 - Kotecha, Sailesh
A1 - Kreiner-Moller, Eskil
A1 - Kulohoma, Benard
A1 - Kumar, Ashish
A1 - Kutalik, Zoltan
A1 - Lahti, Jari
A1 - Lappe, Joan M.
A1 - Larsson, Henrik
A1 - Lehtimaki, Terho
A1 - Lewin, Alexandra M.
A1 - Li, Jin
A1 - Lichtenstein, Paul
A1 - Lindgren, Cecilia M.
A1 - Lindi, Virpi
A1 - Linneberg, Allan
A1 - Liu, Xueping
A1 - Liu, Jun
A1 - Lowe, William L.
A1 - Lundstrom, Sebastian
A1 - Lyytikainen, Leo-Pekka
A1 - Ma, Ronald C. W.
A1 - Mace, Aurelien
A1 - Magi, Reedik
A1 - Magnus, Per
A1 - Mamun, Abdullah A.
A1 - Mannikko, Minna
A1 - Martin, Nicholas G.
A1 - Mbarek, Hamdi
A1 - McCarthy, Nina S.
A1 - Medland, Sarah E.
A1 - Melbye, Mads
A1 - Melen, Erik
A1 - Mohlke, Karen L.
A1 - Monnereau, Claire
A1 - Morgen, Camilla S.
A1 - Morris, Andrew P.
A1 - Murray, Jeffrey C.
A1 - Myhre, Ronny
A1 - Najman, Jackob M.
A1 - Nivard, Michel G.
A1 - Nohr, Ellen A.
A1 - Nolte, Ilja M.
A1 - Ntalla, Ioanna
A1 - Oberfield, Sharon E.
A1 - Oken, Emily
A1 - Oldehinkel, Albertine J.
A1 - Pahkala, Katja
A1 - Palviainen, Teemu
A1 - Panoutsopoulou, Kalliope
A1 - Pedersen, Oluf
A1 - Pennell, Craig E.
A1 - Pershagen, Goran
A1 - Pitkanen, Niina
A1 - Plomin, Robert
A1 - Power, Christine
A1 - Prasad, Rashmi B.
A1 - Prokopenko, Inga
A1 - Pulkkinen, Lea
A1 - Raikkonen, Katri
A1 - Raitakari, Olli T.
A1 - Reynolds, Rebecca M.
A1 - Richmond, Rebecca C.
A1 - Rivadeneira, Fernando
A1 - Rodriguez, Alina
A1 - Rose, Richard J.
A1 - Salem, Rany
A1 - Santa-Marina, Loreto
A1 - Saw, Seang-Mei
A1 - Schnurr, Theresia M.
A1 - Scott, James G.
A1 - Selzam, Saskia
A1 - Shepherd, John A.
A1 - Simpson, Angela
A1 - Skotte, Line
A1 - Sleiman, Patrick M. A.
A1 - Snieder, Harold
A1 - Sorensen, Thorkild I. A.
A1 - Standl, Marie
A1 - Steegers, Eric A. P.
A1 - Strachan, David P.
A1 - Straker, Leon
A1 - Strandberg, Timo
A1 - Taylor, Michelle
A1 - Teo, Yik-Ying
A1 - Thiering, Elisabeth
A1 - Torrent, Maties
A1 - Tyrrell, Jessica
A1 - Uitterlinden, Andre G.
A1 - van Beijsterveldt, Toos
A1 - van der Most, Peter J.
A1 - van Duijn, Cornelia M.
A1 - Viikari, Jorma
A1 - Vilor-Tejedor, Natalia
A1 - Vogelezang, Suzanne
A1 - Vonk, Judith M.
A1 - Vrijkotte, Tanja G. M.
A1 - Vuoksimaa, Eero
A1 - Wang, Carol A.
A1 - Watkins, William J.
A1 - Wichmann, H-Erich
A1 - Willemsen, Gonneke
A1 - Williams, Gail M.
A1 - Wilson, James F.
A1 - Wray, Naomi R.
A1 - Xu, Shujing
A1 - Xu, Cheng-Jian
A1 - Yaghootkar, Hanieh
A1 - Yi, Lu
A1 - Zafarmand, Mohammad Hadi
A1 - Zeggini, Eleftheria
A1 - Zemel, Babette S.
A1 - Hinney, Anke
A1 - Lakka, Timo A.
A1 - Whitehouse, Andrew J. O.
A1 - Sunyer, Jordi
A1 - Widen, Elisabeth E.
A1 - Feenstra, Bjarke
A1 - Sebert, Sylvain
A1 - Jacobsson, Bo
A1 - Njolstad, Pal R.
A1 - Stoltenberg, Camilla
A1 - Smith, George Davey
A1 - Lawlor, Debbie A.
A1 - Paternoster, Lavinia
A1 - Timpson, Nicholas J.
A1 - Ong, Ken K.
A1 - Bisgaard, Hans
A1 - Bonnelykke, Klaus
A1 - Jaddoe, Vincent W. V.
A1 - Tiemeier, Henning
A1 - Jarvelin, Marjo-Riitta
A1 - Evans, David M.
A1 - Perry, John R. B.
A1 - Grant, Struan F. A.
A1 - Boomsma, Dorret I.
A1 - Freathy, Rachel M.
A1 - McCarthy, Mark I.
A1 - Felix, Janine F.
T1 - The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
BT - design, results and future prospects
JF - European journal of epidemiology
N2 - The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
KW - Genetics
KW - Consortium
KW - Childhood traits and disorders
KW - Longitudinal
Y1 - 2019
U6 - https://doi.org/10.1007/s10654-019-00502-9
SN - 0393-2990
SN - 1573-7284
VL - 34
IS - 3
SP - 279
EP - 300
PB - Springer
CY - Dordrecht
ER -
TY - JOUR
A1 - Wuttke, Matthias
A1 - Li, Yong
A1 - Li, Man
A1 - Sieber, Karsten B.
A1 - Feitosa, Mary F.
A1 - Gorski, Mathias
A1 - Tin, Adrienne
A1 - Wang, Lihua
A1 - Chu, Audrey Y.
A1 - Hoppmann, Anselm
A1 - Kirsten, Holger
A1 - Giri, Ayush
A1 - Chai, Jin-Fang
A1 - Sveinbjornsson, Gardar
A1 - Tayo, Bamidele O.
A1 - Nutile, Teresa
A1 - Fuchsberger, Christian
A1 - Marten, Jonathan
A1 - Cocca, Massimiliano
A1 - Ghasemi, Sahar
A1 - Xu, Yizhe
A1 - Horn, Katrin
A1 - Noce, Damia
A1 - Van der Most, Peter J.
A1 - Sedaghat, Sanaz
A1 - Yu, Zhi
A1 - Akiyama, Masato
A1 - Afaq, Saima
A1 - Ahluwalia, Tarunveer Singh
A1 - Almgren, Peter
A1 - Amin, Najaf
A1 - Arnlov, Johan
A1 - Bakker, Stephan J. L.
A1 - Bansal, Nisha
A1 - Baptista, Daniela
A1 - Bergmann, Sven
A1 - Biggs, Mary L.
A1 - Biino, Ginevra
A1 - Boehnke, Michael
A1 - Boerwinkle, Eric
A1 - Boissel, Mathilde
A1 - Böttinger, Erwin
A1 - Boutin, Thibaud S.
A1 - Brenner, Hermann
A1 - Brumat, Marco
A1 - Burkhardt, Ralph
A1 - Butterworth, Adam S.
A1 - Campana, Eric
A1 - Campbell, Archie
A1 - Campbell, Harry
A1 - Canouil, Mickael
A1 - Carroll, Robert J.
A1 - Catamo, Eulalia
A1 - Chambers, John C.
A1 - Chee, Miao-Ling
A1 - Chee, Miao-Li
A1 - Chen, Xu
A1 - Cheng, Ching-Yu
A1 - Cheng, Yurong
A1 - Christensen, Kaare
A1 - Cifkova, Renata
A1 - Ciullo, Marina
A1 - Concas, Maria Pina
A1 - Cook, James P.
A1 - Coresh, Josef
A1 - Corre, Tanguy
A1 - Sala, Cinzia Felicita
A1 - Cusi, Daniele
A1 - Danesh, John
A1 - Daw, E. Warwick
A1 - De Borst, Martin H.
A1 - De Grandi, Alessandro
A1 - De Mutsert, Renee
A1 - De Vries, Aiko P. J.
A1 - Degenhardt, Frauke
A1 - Delgado, Graciela
A1 - Demirkan, Ayse
A1 - Di Angelantonio, Emanuele
A1 - Dittrich, Katalin
A1 - Divers, Jasmin
A1 - Dorajoo, Rajkumar
A1 - Eckardt, Kai-Uwe
A1 - Ehret, Georg
A1 - Elliott, Paul
A1 - Endlich, Karlhans
A1 - Evans, Michele K.
A1 - Felix, Janine F.
A1 - Foo, Valencia Hui Xian
A1 - Franco, Oscar H.
A1 - Franke, Andre
A1 - Freedman, Barry I.
A1 - Freitag-Wolf, Sandra
A1 - Friedlander, Yechiel
A1 - Froguel, Philippe
A1 - Gansevoort, Ron T.
A1 - Gao, He
A1 - Gasparini, Paolo
A1 - Gaziano, J. Michael
A1 - Giedraitis, Vilmantas
A1 - Gieger, Christian
A1 - Girotto, Giorgia
A1 - Giulianini, Franco
A1 - Gogele, Martin
A1 - Gordon, Scott D.
A1 - Gudbjartsson, Daniel F.
A1 - Gudnason, Vilmundur
A1 - Haller, Toomas
A1 - Hamet, Pavel
A1 - Harris, Tamara B.
A1 - Hartman, Catharina A.
A1 - Hayward, Caroline
A1 - Hellwege, Jacklyn N.
A1 - Heng, Chew-Kiat
A1 - Hicks, Andrew A.
A1 - Hofer, Edith
A1 - Huang, Wei
A1 - Hutri-Kahonen, Nina
A1 - Hwang, Shih-Jen
A1 - Ikram, M. Arfan
A1 - Indridason, Olafur S.
A1 - Ingelsson, Erik
A1 - Ising, Marcus
A1 - Jaddoe, Vincent W. V.
A1 - Jakobsdottir, Johanna
A1 - Jonas, Jost B.
A1 - Joshi, Peter K.
A1 - Josyula, Navya Shilpa
A1 - Jung, Bettina
A1 - Kahonen, Mika
A1 - Kamatani, Yoichiro
A1 - Kammerer, Candace M.
A1 - Kanai, Masahiro
A1 - Kastarinen, Mika
A1 - Kerr, Shona M.
A1 - Khor, Chiea-Chuen
A1 - Kiess, Wieland
A1 - Kleber, Marcus E.
A1 - Koenig, Wolfgang
A1 - Kooner, Jaspal S.
A1 - Korner, Antje
A1 - Kovacs, Peter
A1 - Kraja, Aldi T.
A1 - Krajcoviechova, Alena
A1 - Kramer, Holly
A1 - Kramer, Bernhard K.
A1 - Kronenberg, Florian
A1 - Kubo, Michiaki
A1 - Kuhnel, Brigitte
A1 - Kuokkanen, Mikko
A1 - Kuusisto, Johanna
A1 - La Bianca, Martina
A1 - Laakso, Markku
A1 - Lange, Leslie A.
A1 - Langefeld, Carl D.
A1 - Lee, Jeannette Jen-Mai
A1 - Lehne, Benjamin
A1 - Lehtimaki, Terho
A1 - Lieb, Wolfgang
A1 - Lim, Su-Chi
A1 - Lind, Lars
A1 - Lindgren, Cecilia M.
A1 - Liu, Jun
A1 - Liu, Jianjun
A1 - Loeffler, Markus
A1 - Loos, Ruth J. F.
A1 - Lucae, Susanne
A1 - Lukas, Mary Ann
A1 - Lyytikainen, Leo-Pekka
A1 - Magi, Reedik
A1 - Magnusson, Patrik K. E.
A1 - Mahajan, Anubha
A1 - Martin, Nicholas G.
A1 - Martins, Jade
A1 - Marz, Winfried
A1 - Mascalzoni, Deborah
A1 - Matsuda, Koichi
A1 - Meisinger, Christa
A1 - Meitinger, Thomas
A1 - Melander, Olle
A1 - Metspalu, Andres
A1 - Mikaelsdottir, Evgenia K.
A1 - Milaneschi, Yuri
A1 - Miliku, Kozeta
A1 - Mishra, Pashupati P.
A1 - Program, V. A. Million Veteran
A1 - Mohlke, Karen L.
A1 - Mononen, Nina
A1 - Montgomery, Grant W.
A1 - Mook-Kanamori, Dennis O.
A1 - Mychaleckyj, Josyf C.
A1 - Nadkarni, Girish N.
A1 - Nalls, Mike A.
A1 - Nauck, Matthias
A1 - Nikus, Kjell
A1 - Ning, Boting
A1 - Nolte, Ilja M.
A1 - Noordam, Raymond
A1 - Olafsson, Isleifur
A1 - Oldehinkel, Albertine J.
A1 - Orho-Melander, Marju
A1 - Ouwehand, Willem H.
A1 - Padmanabhan, Sandosh
A1 - Palmer, Nicholette D.
A1 - Palsson, Runolfur
A1 - Penninx, Brenda W. J. H.
A1 - Perls, Thomas
A1 - Perola, Markus
A1 - Pirastu, Mario
A1 - Pirastu, Nicola
A1 - Pistis, Giorgio
A1 - Podgornaia, Anna I.
A1 - Polasek, Ozren
A1 - Ponte, Belen
A1 - Porteous, David J.
A1 - Poulain, Tanja
A1 - Pramstaller, Peter P.
A1 - Preuss, Michael H.
A1 - Prins, Bram P.
A1 - Province, Michael A.
A1 - Rabelink, Ton J.
A1 - Raffield, Laura M.
A1 - Raitakari, Olli T.
A1 - Reilly, Dermot F.
A1 - Rettig, Rainer
A1 - Rheinberger, Myriam
A1 - Rice, Kenneth M.
A1 - Ridker, Paul M.
A1 - Rivadeneira, Fernando
A1 - Rizzi, Federica
A1 - Roberts, David J.
A1 - Robino, Antonietta
A1 - Rossing, Peter
A1 - Rudan, Igor
A1 - Rueedi, Rico
A1 - Ruggiero, Daniela
A1 - Ryan, Kathleen A.
A1 - Saba, Yasaman
A1 - Sabanayagam, Charumathi
A1 - Salomaa, Veikko
A1 - Salvi, Erika
A1 - Saum, Kai-Uwe
A1 - Schmidt, Helena
A1 - Schmidt, Reinhold
A1 - Ben Schottker,
A1 - Schulz, Christina-Alexandra
A1 - Schupf, Nicole
A1 - Shaffer, Christian M.
A1 - Shi, Yuan
A1 - Smith, Albert V.
A1 - Smith, Blair H.
A1 - Soranzo, Nicole
A1 - Spracklen, Cassandra N.
A1 - Strauch, Konstantin
A1 - Stringham, Heather M.
A1 - Stumvoll, Michael
A1 - Svensson, Per O.
A1 - Szymczak, Silke
A1 - Tai, E-Shyong
A1 - Tajuddin, Salman M.
A1 - Tan, Nicholas Y. Q.
A1 - Taylor, Kent D.
A1 - Teren, Andrej
A1 - Tham, Yih-Chung
A1 - Thiery, Joachim
A1 - Thio, Chris H. L.
A1 - Thomsen, Hauke
A1 - Thorleifsson, Gudmar
A1 - Toniolo, Daniela
A1 - Tonjes, Anke
A1 - Tremblay, Johanne
A1 - Tzoulaki, Ioanna
A1 - Uitterlinden, Andre G.
A1 - Vaccargiu, Simona
A1 - Van Dam, Rob M.
A1 - Van der Harst, Pim
A1 - Van Duijn, Cornelia M.
A1 - Edward, Digna R. Velez
A1 - Verweij, Niek
A1 - Vogelezang, Suzanne
A1 - Volker, Uwe
A1 - Vollenweider, Peter
A1 - Waeber, Gerard
A1 - Waldenberger, Melanie
A1 - Wallentin, Lars
A1 - Wang, Ya Xing
A1 - Wang, Chaolong
A1 - Waterworth, Dawn M.
A1 - Bin Wei, Wen
A1 - White, Harvey
A1 - Whitfield, John B.
A1 - Wild, Sarah H.
A1 - Wilson, James F.
A1 - Wojczynski, Mary K.
A1 - Wong, Charlene
A1 - Wong, Tien-Yin
A1 - Xu, Liang
A1 - Yang, Qiong
A1 - Yasuda, Masayuki
A1 - Yerges-Armstrong, Laura M.
A1 - Zhang, Weihua
A1 - Zonderman, Alan B.
A1 - Rotter, Jerome I.
A1 - Bochud, Murielle
A1 - Psaty, Bruce M.
A1 - Vitart, Veronique
A1 - Wilson, James G.
A1 - Dehghan, Abbas
A1 - Parsa, Afshin
A1 - Chasman, Daniel I.
A1 - Ho, Kevin
A1 - Morris, Andrew P.
A1 - Devuyst, Olivier
A1 - Akilesh, Shreeram
A1 - Pendergrass, Sarah A.
A1 - Sim, Xueling
A1 - Boger, Carsten A.
A1 - Okada, Yukinori
A1 - Edwards, Todd L.
A1 - Snieder, Harold
A1 - Stefansson, Kari
A1 - Hung, Adriana M.
A1 - Heid, Iris M.
A1 - Scholz, Markus
A1 - Teumer, Alexander
A1 - Kottgen, Anna
A1 - Pattaro, Cristian
T1 - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF - Nature genetics
N2 - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1 - 2019
U6 - https://doi.org/10.1038/s41588-019-0407-x
SN - 1061-4036
SN - 1546-1718
VL - 51
IS - 6
SP - 957
EP - +
PB - Nature Publ. Group
CY - New York
ER -
TY - JOUR
A1 - Abdalla, H.
A1 - Adam, R.
A1 - Aharonian, Felix A.
A1 - Benkhali, F. Ait
A1 - Angüner, Ekrem Oǧuzhan
A1 - Arcaro, C.
A1 - Armand, C.
A1 - Armstrong, T.
A1 - Ashkar, H.
A1 - Backes, M.
A1 - Baghmanyan, V.
A1 - Martins, V. Barbosa
A1 - Barnacka, A.
A1 - Barnard, M.
A1 - Becherini, Y.
A1 - Berge, D.
A1 - Bernlohr, K.
A1 - Bi, B.
A1 - Bottcher, M.
A1 - Boisson, C.
A1 - Bolmont, J.
A1 - de Lavergne, M. de Bony
A1 - Bordas, Pol
A1 - Breuhaus, M.
A1 - Brun, F.
A1 - Brun, P.
A1 - Bryan, M.
A1 - Buchele, M.
A1 - Bulik, T.
A1 - Bylund, T.
A1 - Caroff, S.
A1 - Carosi, A.
A1 - Casanova, Sabrina
A1 - Chand, T.
A1 - Chandra, S.
A1 - Chen, A.
A1 - Cotter, G.
A1 - Curylo, M.
A1 - Mbarubucyeye, J. Damascene
A1 - Davids, I. D.
A1 - Davies, J.
A1 - Deil, C.
A1 - Devin, J.
A1 - deWilt, P.
A1 - Dirson, L.
A1 - Djannati-Atai, A.
A1 - Dmytriiev, A.
A1 - Donath, A.
A1 - Doroshenko, V.
A1 - Duffy, C.
A1 - Dyks, J.
A1 - Egberts, Kathrin
A1 - Eichhorn, F.
A1 - Einecke, S.
A1 - Emery, G.
A1 - Ernenwein, J. -P.
A1 - Feijen, K.
A1 - Fegan, S.
A1 - Fiasson, A.
A1 - de Clairfontaine, G. Fichet
A1 - Fontaine, G.
A1 - Funk, S.
A1 - Fussling, Matthias
A1 - Gabici, S.
A1 - Gallant, Y. A.
A1 - Giavitto, G.
A1 - Giunti, L.
A1 - Glawion, D.
A1 - Glicenstein, J. F.
A1 - Gottschall, D.
A1 - Grondin, M. -H.
A1 - Hahn, J.
A1 - Haupt, M.
A1 - Hermann, G.
A1 - Hinton, J. A.
A1 - Hofmann, W.
A1 - Hoischen, Clemens
A1 - Holch, T. L.
A1 - Holler, M.
A1 - Horbe, M.
A1 - Horns, D.
A1 - Huber, D.
A1 - Jamrozy, M.
A1 - Jankowsky, D.
A1 - Jankowsky, F.
A1 - Jardin-Blicq, A.
A1 - Joshi, V.
A1 - Jung-Richardt, I.
A1 - Kasai, E.
A1 - Kastendieck, M. A.
A1 - Katarzynski, K.
A1 - Katz, U.
A1 - Khangulyan, D.
A1 - Khelifi, B.
A1 - Klepser, S.
A1 - Kluzniak, W.
A1 - Komin, Nu.
A1 - Konno, R.
A1 - Kosack, K.
A1 - Kostunin, D.
A1 - Kreter, M.
A1 - Lamanna, G.
A1 - Lemiere, A.
A1 - Lemoine-Goumard, M.
A1 - Lenain, J. -P.
A1 - Levy, C.
A1 - Lohse, T.
A1 - Lypova, I.
A1 - Mackey, J.
A1 - Majumdar, J.
A1 - Malyshev, D.
A1 - Malyshev, D.
A1 - Marandon, V.
A1 - Marchegiani, P.
A1 - Marcowith, Alexandre
A1 - Mares, A.
A1 - Marti-Devesa, G.
A1 - Marx, R.
A1 - Maurin, G.
A1 - Meintjes, P. J.
A1 - Meyer, M.
A1 - Mitchell, A.
A1 - Moderski, R.
A1 - Mohamed, M.
A1 - Mohrmann, L.
A1 - Montanari, A.
A1 - Moore, C.
A1 - Morris, P.
A1 - Moulin, Emmanuel
A1 - Muller, J.
A1 - Murach, T.
A1 - Nakashima, K.
A1 - Nayerhoda, A.
A1 - de Naurois, M.
A1 - Ndiyavala, H.
A1 - Niederwanger, F.
A1 - Niemiec, J.
A1 - Oakes, L.
A1 - O'Brien, Patrick
A1 - Odaka, H.
A1 - Ohm, S.
A1 - Olivera-Nieto, L.
A1 - Wilhelmi, E. de Ona
A1 - Ostrowski, M.
A1 - Oya, I.
A1 - Panter, M.
A1 - Panny, S.
A1 - Parsons, R. D.
A1 - Peron, G.
A1 - Peyaud, B.
A1 - Piel, Q.
A1 - Pita, S.
A1 - Poireau, V.
A1 - Noel, A. Priyana
A1 - Prokhorov, D. A.
A1 - Prokoph, H.
A1 - Puhlhofer, G.
A1 - Punch, M.
A1 - Quirrenbach, A.
A1 - Raab, S.
A1 - Rauth, R.
A1 - Reichherzer, P.
A1 - Reimer, A.
A1 - Reimer, O.
A1 - Remy, Q.
A1 - Renaud, M.
A1 - Rieger, F.
A1 - Rinchiuso, L.
A1 - Romoli, C.
A1 - Rowell, G.
A1 - Rudak, B.
A1 - Ruiz-Velasco, E.
A1 - Sahakian, V.
A1 - Sailer, S.
A1 - Sanchez, D. A.
A1 - Santangelo, Andrea
A1 - Sasaki, M.
A1 - Scalici, M.
A1 - Schussler, F.
A1 - Schutte, H. M.
A1 - Schwanke, U.
A1 - Schwemmer, S.
A1 - Seglar-Arroyo, M.
A1 - Senniappan, M.
A1 - Seyffert, A. S.
A1 - Shafi, N.
A1 - Shiningayamwe, K.
A1 - Simoni, R.
A1 - Sinha, A.
A1 - Sol, H.
A1 - Specovius, A.
A1 - Spencer, S.
A1 - Spir-Jacob, M.
A1 - Stawarz, L.
A1 - Sun, L.
A1 - Steenkamp, R.
A1 - Stegmann, C.
A1 - Steinmassl, S.
A1 - Steppa, C.
A1 - Takahashi, T.
A1 - Tavernier, T.
A1 - Taylor, A. M.
A1 - Terrier, R.
A1 - Tiziani, D.
A1 - Tluczykont, M.
A1 - Tomankova, L.
A1 - Trichard, C.
A1 - Tsirou, M.
A1 - Tuffs, R.
A1 - Uchiyama, Y.
A1 - van der Walt, D. J.
A1 - van Eldik, C.
A1 - van Rensburg, C.
A1 - van Soelen, B.
A1 - Vasileiadis, G.
A1 - Veh, J.
A1 - Venter, C.
A1 - Vincent, P.
A1 - Vink, J.
A1 - Volk, H. J.
A1 - Vuillaume, T.
A1 - Wadiasingh, Z.
A1 - Wagner, S. J.
A1 - Watson, J.
A1 - Werner, F.
A1 - White, R.
A1 - Wierzcholska, A.
A1 - Wong, Yu Wun
A1 - Yusafzai, A.
A1 - Zacharias, M.
A1 - Zanin, R.
A1 - Zargaryan, D.
A1 - Zdziarski, A. A.
A1 - Zech, Alraune
A1 - Zhu, S. J.
A1 - Ziegler, A.
A1 - Zorn, J.
A1 - Zouari, S.
A1 - Zywucka, N.
T1 - An extreme particle accelerator in the Galactic plane
BT - HESS J1826-130
JF - Astronomy and astrophysics : an international weekly journal
N2 - The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02
(stat)degrees
stat degrees +/- 0.05
(sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2
(+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
KW - ISM: supernova remnants
KW - ISM: clouds
KW - gamma rays: general
KW - gamma rays:
KW - ISM
Y1 - 2020
U6 - https://doi.org/10.1051/0004-6361/202038851
SN - 0004-6361
SN - 1432-0746
VL - 644
PB - EDP Sciences
CY - Les Ulis
ER -
TY - JOUR
A1 - Warrington, Nicole
A1 - Beaumont, Robin
A1 - Horikoshi, Momoko
A1 - Day, Felix R.
A1 - Helgeland, Øyvind
A1 - Laurin, Charles
A1 - Bacelis, Jonas
A1 - Peng, Shouneng
A1 - Hao, Ke
A1 - Feenstra, Bjarke
A1 - Wood, Andrew R.
A1 - Mahajan, Anubha
A1 - Tyrrell, Jessica
A1 - Robertson, Neil R.
A1 - Rayner, N. William
A1 - Qiao, Zhen
A1 - Moen, Gunn-Helen
A1 - Vaudel, Marc
A1 - Marsit, Carmen
A1 - Chen, Jia
A1 - Nodzenski, Michael
A1 - Schnurr, Theresia M.
A1 - Zafarmand, Mohammad Hadi
A1 - Bradfield, Jonathan P.
A1 - Grarup, Niels
A1 - Kooijman, Marjolein N.
A1 - Li-Gao, Ruifang
A1 - Geller, Frank
A1 - Ahluwalia, Tarunveer Singh
A1 - Paternoster, Lavinia
A1 - Rueedi, Rico
A1 - Huikari, Ville
A1 - Hottenga, Jouke-Jan
A1 - Lyytikäinen, Leo-Pekka
A1 - Cavadino, Alana
A1 - Metrustry, Sarah
A1 - Cousminer, Diana L.
A1 - Wu, Ying
A1 - Thiering, Elisabeth Paula
A1 - Wang, Carol A.
A1 - Have, Christian Theil
A1 - Vilor-Tejedor, Natalia
A1 - Joshi, Peter K.
A1 - Painter, Jodie N.
A1 - Ntalla, Ioanna
A1 - Myhre, Ronny
A1 - Pitkänen, Niina
A1 - van Leeuwen, Elisabeth M.
A1 - Joro, Raimo
A1 - Lagou, Vasiliki
A1 - Richmond, Rebecca C.
A1 - Espinosa, Ana
A1 - Barton, Sheila J.
A1 - Inskip, Hazel M.
A1 - Holloway, John W.
A1 - Santa-Marina, Loreto
A1 - Estivill, Xavier
A1 - Ang, Wei
A1 - Marsh, Julie A.
A1 - Reichetzeder, Christoph
A1 - Marullo, Letizia
A1 - Hocher, Berthold
A1 - Lunetta, Kathryn L.
A1 - Murabito, Joanne M.
A1 - Relton, Caroline L.
A1 - Kogevinas, Manolis
A1 - Chatzi, Leda
A1 - Allard, Catherine
A1 - Bouchard, Luigi
A1 - Hivert, Marie-France
A1 - Zhang, Ge
A1 - Muglia, Louis J.
A1 - Heikkinen, Jani
A1 - Morgen, Camilla S.
A1 - van Kampen, Antoine H. C.
A1 - van Schaik, Barbera D. C.
A1 - Mentch, Frank D.
A1 - Langenberg, Claudia
A1 - Scott, Robert A.
A1 - Zhao, Jing Hua
A1 - Hemani, Gibran
A1 - Ring, Susan M.
A1 - Bennett, Amanda J.
A1 - Gaulton, Kyle J.
A1 - Fernandez-Tajes, Juan
A1 - van Zuydam, Natalie R.
A1 - Medina-Gomez, Carolina
A1 - de Haan, Hugoline G.
A1 - Rosendaal, Frits R.
A1 - Kutalik, Zoltán
A1 - Marques-Vidal, Pedro
A1 - Das, Shikta
A1 - Willemsen, Gonneke
A1 - Mbarek, Hamdi
A1 - Müller-Nurasyid, Martina
A1 - Standl, Marie
A1 - Appel, Emil V. R.
A1 - Fonvig, Cilius Esmann
A1 - Trier, Caecilie
A1 - van Beijsterveldt, Catharina E. M.
A1 - Murcia, Mario
A1 - Bustamante, Mariona
A1 - Bonàs-Guarch, Sílvia
A1 - Hougaard, David M.
A1 - Mercader, Josep M.
A1 - Linneberg, Allan
A1 - Schraut, Katharina E.
A1 - Lind, Penelope A.
A1 - Medland, Sarah Elizabeth
A1 - Shields, Beverley M.
A1 - Knight, Bridget A.
A1 - Chai, Jin-Fang
A1 - Panoutsopoulou, Kalliope
A1 - Bartels, Meike
A1 - Sánchez, Friman
A1 - Stokholm, Jakob
A1 - Torrents, David
A1 - Vinding, Rebecca K.
A1 - Willems, Sara M.
A1 - Atalay, Mustafa
A1 - Chawes, Bo L.
A1 - Kovacs, Peter
A1 - Prokopenko, Inga
A1 - Tuke, Marcus A.
A1 - Yaghootkar, Hanieh
A1 - Ruth, Katherine S.
A1 - Jones, Samuel E.
A1 - Loh, Po-Ru
A1 - Murray, Anna
A1 - Weedon, Michael N.
A1 - Tönjes, Anke
A1 - Stumvoll, Michael
A1 - Michaelsen, Kim Fleischer
A1 - Eloranta, Aino-Maija
A1 - Lakka, Timo A.
A1 - van Duijn, Cornelia M.
A1 - Kiess, Wieland
A1 - Koerner, Antje
A1 - Niinikoski, Harri
A1 - Pahkala, Katja
A1 - Raitakari, Olli T.
A1 - Jacobsson, Bo
A1 - Zeggini, Eleftheria
A1 - Dedoussis, George V.
A1 - Teo, Yik-Ying
A1 - Saw, Seang-Mei
A1 - Montgomery, Grant W.
A1 - Campbell, Harry
A1 - Wilson, James F.
A1 - Vrijkotte, Tanja G. M.
A1 - Vrijheid, Martine
A1 - de Geus, Eco J. C. N.
A1 - Hayes, M. Geoffrey
A1 - Kadarmideen, Haja N.
A1 - Holm, Jens-Christian
A1 - Beilin, Lawrence J.
A1 - Pennell, Craig E.
A1 - Heinrich, Joachim
A1 - Adair, Linda S.
A1 - Borja, Judith B.
A1 - Mohlke, Karen L.
A1 - Eriksson, Johan G.
A1 - Widen, Elisabeth E.
A1 - Hattersley, Andrew T.
A1 - Spector, Tim D.
A1 - Kaehoenen, Mika
A1 - Viikari, Jorma S.
A1 - Lehtimaeki, Terho
A1 - Boomsma, Dorret I.
A1 - Sebert, Sylvain
A1 - Vollenweider, Peter
A1 - Sorensen, Thorkild I. A.
A1 - Bisgaard, Hans
A1 - Bonnelykke, Klaus
A1 - Murray, Jeffrey C.
A1 - Melbye, Mads
A1 - Nohr, Ellen A.
A1 - Mook-Kanamori, Dennis O.
A1 - Rivadeneira, Fernando
A1 - Hofman, Albert
A1 - Felix, Janine F.
A1 - Jaddoe, Vincent W. V.
A1 - Hansen, Torben
A1 - Pisinger, Charlotta
A1 - Vaag, Allan A.
A1 - Pedersen, Oluf
A1 - Uitterlinden, Andre G.
A1 - Jarvelin, Marjo-Riitta
A1 - Power, Christine
A1 - Hypponen, Elina
A1 - Scholtens, Denise M.
A1 - Lowe, William L.
A1 - Smith, George Davey
A1 - Timpson, Nicholas J.
A1 - Morris, Andrew P.
A1 - Wareham, Nicholas J.
A1 - Hakonarson, Hakon
A1 - Grant, Struan F. A.
A1 - Frayling, Timothy M.
A1 - Lawlor, Debbie A.
A1 - Njolstad, Pal R.
A1 - Johansson, Stefan
A1 - Ong, Ken K.
A1 - McCarthy, Mark I.
A1 - Perry, John R. B.
A1 - Evans, David M.
A1 - Freathy, Rachel M.
T1 - Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
JF - Nature genetics
N2 - Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Y1 - 2019
SN - 1061-4036
SN - 1546-1718
VL - 51
IS - 5
SP - 804
EP - +
PB - Nature Publ. Group
CY - New York
ER -
TY - JOUR
A1 - Marston, A. P.
A1 - Mauerhan, J.
A1 - Morris, P. W.
A1 - Van Dyk, S.
T1 - Finding Wolf-Rayet Stars in the Milky Way
BT - Inputs to Star Formation and Stellar Evolution
JF - Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.–5. June 2015
N2 - The total population of Wolf-Rayet (WR) stars in the Galaxy is predicted by models to be as many as ~6000 stars, and yet the number of catalogued WR stars as a result of optical surveys was far lower than this (~200) at the turn of this century. When beginning our WR searches using infrared techniques it was not clear whether WR number predictions were too optimistic or whether there was more hidden behind interstellar and circumstellar extinction. During the last decade we pioneered a technique of exploiting the near- and mid-infrared continuum colours for individual point sources provided by large-format surveys of the Galaxy, including 2MASS and Spitzer/GLIMPSE, to pierce through the dust and reveal newly discovered WR stars throughout the Galactic Plane. The key item to the colour discrimination is via the characteristic infrared spectral index produced by the strong winds of the WR stars, combined with dust extinction, which place WR stars in a relatively depopulated area of infrared colour-colour diagrams. The use of the Spitzer/GLIMPSE 8µm and, more recently, WISE 22µm fluxes together with cross-referencing with X-ray measurements in selected Galactic regions have enabled improved candidate lists that increased our confirmation success rate, achieved via follow-up infrared and optical spectroscopy. To date a total of 102 new WR stars have been found with many more
candidates still available for follow-up. This constitutes an addition of ~16% to the current
inventory of 642 Galactic WR stars. In this talk we review our methods and provide some
new results and a preliminary review of their stellar and interstellar medium environments. We provide a roadmap for the future of this search, including statistical modeling, and what we can add to star formation and high mass star evolution studies.
Y1 - 2015
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-87577
SP - 27
EP - 30
ER -
TY - JOUR
A1 - Morris, P. W.
T1 - Measuring η Carinae's High Mass Ejecta in the Infrared and Sub-millimeter
JF - Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.–5. June 2015
N2 - I address uncertainties on the spatial distribution and mass of the dust formed in η Carinae's Homunculus nebula with data being combined from several space- and ground-based facilities spanning near-infrared to sub-mm wavelengths, in terms of observational constraints and modeling. Until these aspects are better understood, the mass loss history and mechanisms responsible for η Car's enormous eruption(s) remain poorly constrained.
Y1 - 2015
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-87895
SP - 155
EP - 158
ER -