TY - JOUR A1 - Wetzel, Anna-Jasmin A1 - Koch, Roland A1 - Preiser, Christine A1 - Müller, Regina A1 - Klemmt, Malte A1 - Ranisch, Robert A1 - Ehni, Hans-Jörg A1 - Wiesing, Urban A1 - Rieger, Monika A. A1 - Henking, Tanja A1 - Joos, Stefanie T1 - Ethical, legal, and social implications of symptom checker Apps in primary Health Care (CHECK.APP) BT - protocol for an interdisciplinary mixed methods study JF - JMIR Research Protocols N2 - Background: Symptom checker apps (SCAs) are accessible tools that provide early symptom assessment for users. The ethical, legal, and social implications of SCAs and their impact on the patient-physician relationship, the health care providers, and the health care system have sparsely been examined. This study protocol describes an approach to investigate the possible impacts and implications of SCAs on different levels of health care provision. It considers the perspectives of the users, nonusers, general practitioners (GPs), and health care experts. Objective: We aim to assess a comprehensive overview of the use of SCAs and address problematic issues, if any. The primary outcomes of this study are empirically informed multi-perspective recommendations for different stakeholders on the ethical, legal, and social implications of SCAs. Methods: Quantitative and qualitative methods will be used in several overlapping and interconnected study phases. In study phase 1, a comprehensive literature review will be conducted to assess the ethical, legal, social, and systemic impacts of SCAs. Study phase 2 comprises a survey that will be analyzed with a logistic regression. It aims to assess the user degree of SCAs in Germany as well as the predictors for SCA usage. Study phase 3 will investigate self-observational diaries and user interviews, which will be analyzed as integrated cases to assess user perspectives, usage pattern, and arising problems. Study phase 4 will comprise GP interviews to assess their experiences, perspectives, self-image, and concepts and will be analyzed with the basic procedure by Kruse. Moreover, interviews with health care experts will be conducted in study phase 3 and will be analyzed by using the reflexive thematical analysis approach of Braun and Clark. Results: Study phase 1 will be completed in November 2021. We expect the results of study phase 2 in December 2021 and February 2022. In study phase 3, interviews are currently being conducted. The final study endpoint will be in February 2023. Conclusions: The possible ethical, legal, social, and systemic impacts of a widespread use of SCAs that affect stakeholders and stakeholder groups on different levels of health care will be identified. The proposed methodological approach provides a multifaceted and diverse empirical basis for a broad discussion on these implications. KW - symptom checker apps KW - self-diagnosis KW - self-triage KW - digitalization in KW - primary care KW - general practitioners KW - symptom checker KW - app KW - mobile app; Y1 - 2022 U6 - https://doi.org/10.2196/34026 SN - 1929-0748 VL - 11 IS - 5 PB - JMIR Research Protocols CY - Toronto ER - TY - JOUR A1 - Schlickewei, Ole A1 - Nienstedt, Julie Cläre A1 - Frank, Ulrike A1 - Fründt, Odette A1 - Pötter-Nerger, Monika A1 - Gerloff, Christian A1 - Buhmann, Carsten A1 - Müller, Frank A1 - Lezius, Susanne A1 - Koseki, Jana-Christiane A1 - Pflug, Christina T1 - The ability of the eating assessment tool‑10 to detect penetration and aspiration in Parkinson’s disease JF - European archives of oto-rhino-laryngology and head & neck N2 - Purpose: Dysphagia is common in patients with Parkinson's disease (PD) and often leads to pneumonia, malnutrition, and reduced quality of life. This study investigates the ability of the Eating Assessment Tool-10 (EAT-10), an established, easy self-administered screening tool, to detect aspiration in PD patients. This study aims to validate the ability of the EAT-10 to detect FEES-proven aspiration in patients with PD. Methods: In a controlled prospective cross-sectional study, a total of 50 PD patients completed the EAT-10 and, subsequently, were examined by Flexible Endoscopic Evaluation of Swallowing (FEES) to determine the swallowing status. The results were rated through the Penetration-Aspiration Scale (PAS) and data were analyzed retrospectively. Results: PAS and EAT-10 did not correlate significantly. Selected items of the EAT-10 could not predict aspiration or residues. 19 (38%) out of 50 patients with either penetration or aspiration were not detected by the EAT-10. The diagnostic accuracy was established at only a sufficient level (AUC 0.65). An optimal cut-off value of >= 6 presented a sensitivity of 58% and specificity of 82%. Conclusions: The EAT-10 is not suited for the detection of penetration and aspiration in PD patients. Therefore, it cannot be used as a screening method in this patient population. There is still a need for a valid, simple, and efficient screening tool to assist physicians in their daily diagnostics and to avoid clinical complications. KW - Parkinson's disease KW - dysphagia KW - questionnaire KW - screening Y1 - 2020 U6 - https://doi.org/10.1007/s00405-020-06377-x SN - 0937-4477 SN - 1434-4726 VL - 278 IS - 5 SP - 1661 EP - 1668 PB - Springer CY - Berlin ER - TY - JOUR A1 - Müller, Monika T1 - Das Schutzgesuch des Moyses Samuel BT - eine landesgeschichtliche Kommentierung JF - Genisa Blätter III KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Landesgeschichte KW - Ländliches Judentum KW - Franconia KW - Rural Jewry KW - regional history Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470942 SN - 978-3-86956-470-8 SP - 59 EP - 65 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Müller, Monika T1 - Moyses Samuel – ein Schutzjude in Westfalen und Reckendorf? BT - einleitende Bemerkungen zu zwei Genisaquellen JF - Genisa Blätter III KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Landesgeschichte KW - Ländliches Judentum KW - Franconia KW - Rural Jewry KW - regional history Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470921 SN - 978-3-86956-470-8 SP - 41 EP - 41 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Müller, Anke Katharina A1 - Helms, Ute A1 - Rohrer, Carsten A1 - Möhler, Monika A1 - Hellwig, Frank A1 - Glei, Michael A1 - Schwerdtle, Tanja A1 - Lorkowski, Stefan A1 - Dawczynski, Christine T1 - Nutrient composition of different hazelnut cultivars grown in Germany JF - Foods N2 - Hazelnuts are rarely cultivated in Germany, although they are a valuable source for macro- and micronutrients and can thus contribute to a healthy diet. Near the present, 15 varieties were cultivated in Thuringia, Germany, as a pilot study for further research. The aim of our study was to evaluate the micro- and macronutrient composition of representative, randomly mixed samples of the 15 different hazelnut cultivars. Protein, fat, and fiber contents were determined using established methods. Fatty acids, tocopherols, minerals, trace elements, and ultra-trace elements were analyzed using gas chromatography, high-performance liquid chromatography, and inductively coupled plasma triple quadrupole mass-spectrometry, respectively. We found that the different hazelnut varieties contained valuable amounts of fat, protein, dietary fiber, minerals, trace elements, and alpha-tocopherol, however, in different quantities. The variations in nutrient composition were independent of growth conditions, which were identical for all hazelnut varieties. Therefore, each hazelnut cultivar has its specific nutrient profile. KW - Corylus avellana L. KW - nutrient composition KW - hazelnut cultivars KW - minerals KW - tocopherols Y1 - 2020 U6 - https://doi.org/10.3390/foods9111596 SN - 2304-8158 VL - 9 IS - 11 PB - MDPI CY - Basel ER - TY - BOOK A1 - Denz, Rebekka A1 - Rudolf, Gabi A1 - Singer-Brehm, Elisabeth A1 - Sowa, Oliver A1 - Müller, Monika A1 - Schulz, Michael Karl A1 - Uličná, Lenka A1 - Ullrich, Rebecca A1 - Weinhold, Beate A1 - Fuchs, Stefanie ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Genisa-Blätter III N2 - Ursprünglich sollten die „Genisa-Blätter III“ ein europäisches Projekt werden. Veröffentlicht werden sollten Quellen aus ­Genisot, die im vormals deutschsprachigen Raum gehoben wurden. Das Vorhaben scheiterte. Nunmehr sind im Band sieben Beiträge versammelt, in denen kenntnisreich Funde aus den Ablagen in Alsenz, Altenschönbach, Memmelsdorf, Reckendorf und Veitshöchheim besprochen werden. Der achte Aufsatz knüpft am internationalen Vorhaben an: Im Mittelpunkt des Artikels stehen drei Genisafunde aus Tschechien, genauer gesagt aus den beiden ostböhmischen Ortschaften Luže und Rychnov nad Kněžnou. Alle acht Beiträge gemeinsam verdeutlichen die inhaltliche Spannbreite von Genisot, die sich die Forschung zunutze machen kann: Sie reicht von Aspekten der Wirtschaft und des Rechts, über die Religion bis hin zum alltäglichen Leben und bietet jeweils eigene Geschichten im Spannungsfeld des möglichen Scheiterns. KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Landesgeschichte KW - Franken KW - Ländliches Judentum KW - regional history KW - Franconia KW - Rural Jewry Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435289 SN - 978-3-86956-470-8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Taran, Michail N. A1 - Nunez Valdez, Maribel A1 - Efthimiopoulos, Ilias A1 - Müller, J. A1 - Reichmann, Hans-Josef A1 - Wilke, Max A1 - Koch-Müller, Monika T1 - Spectroscopic and ab initio studies of the pressure-induced Fe2+ high-spin-to-low-spin electronic transition in natural triphylite-lithiophilite JF - Physics and Chemistry of Minerals N2 - Using optical absorption and Raman spectroscopic measurements, in conjunction with the first-principles calculations, a pressure-induced high-spin (HS)-to-low-spin (LS) state electronic transition of Fe2+ (M2-octahedral site) was resolved around 76-80GPa in a natural triphylite-lithiophilite sample with chemical composition (LiFe0.7082+Mn0.292PO4)-Li-M1-Fe-M2 (theoretical composition (LiFe0.52+Mn0.5PO4)-Li-M1-Fe-M2). The optical absorption spectra at ambient conditions consist of a broad doublet band with two constituents (1) (similar to 9330cm(-1)) and (2) (similar to 7110cm(-1)), resulting from the electronic spin-allowed transition (T2gEg)-T-5-E-5 of octahedral (HSFe2+)-Fe-M2. Both (1) and (2) bands shift non-linearly with pressure to higher energies up to similar to 55GPa. In the optical absorption spectrum measured at similar to 81GPa, the aforementioned HS-related bands disappear, whereas a new broadband with an intensity maximum close to 16,360cm(-1) appears, superimposed on the tail of the high-energy ligand-to-metal O2-Fe2+ charge-transfer absorption edge. We assign this new band to the electronic spin-allowed dd-transition (1)A(1g)(1)T(1g) of LS Fe2+ in octahedral coordination. The high-pressure Raman spectra evidence the Fe2+ HS-to-LS transition mainly from the abrupt shift of the P-O symmetric stretching modes to lower frequencies at similar to 76GPa, the highest pressure achieved in the Raman spectroscopic experiments. Calculations indicated that the presence of Mn-M2(2+) simply shifts the isostructural HS-to-LS transition to higher pressures compared to the triphylite Fe-M2(2+) end-member, in qualitative agreement with our experimental observations. KW - Phosphates KW - Triphylite KW - Raman KW - Infrared KW - Optical absorption spectroscopy KW - High pressure KW - Spin transition KW - DFT Y1 - 2019 U6 - https://doi.org/10.1007/s00269-018-1001-y SN - 0342-1791 SN - 1432-2021 VL - 46 IS - 3 SP - 245 EP - 258 PB - Springer CY - New York ER - TY - JOUR A1 - Nunez Valdez, Maribel A1 - Efthimiopoulos, Ilias A1 - Taran, Michail A1 - Mueller, Jan A1 - Bykova, Elena A1 - McCammon, Catherine A1 - Koch-Müller, Monika A1 - Wilke, Max T1 - Evidence for a pressure-induced spin transition in olivine-type LiFePO4 triphylite JF - Physical review : B, Condensed matter and materials physics N2 - We present a combination of first-principles and experimental results regarding the structural and magnetic properties of olivine-type LiFePO4 under pressure. Our investigations indicate that the starting Pbnm phase of LiFePO4 persists up to 70 GPa. Further compression leads to an isostructural transition in the pressure range of 70-75 GPa, inconsistent with a former theoretical study. Considering our first-principles prediction for a high-spin to low-spin transition of Fe2+ close to 72 GPa, we attribute the experimentally observed isostructural transition to a change in the spin state of Fe2+ in LiFePO4. Compared to relevant Fe-bearing minerals, LiFePO4 exhibits the largest onset pressure for a pressure-induced spin state transition. Y1 - 2018 U6 - https://doi.org/10.1103/PhysRevB.97.184405 SN - 2469-9950 SN - 2469-9969 VL - 97 IS - 18 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Müller, Monika ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Vom Handeln und Schmusen BT - ein Zettel aus der Altenschönbacher Genisa JF - Genisa-Blätter II KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-104659 SP - 111 EP - 117 ER - TY - BOOK A1 - Denz, Rebekka A1 - Rudolf, Gabi A1 - Singer-Brehm, Elisabeth A1 - Koch, Patrick B. A1 - Weinhold, Beate A1 - Wiesner, Linda A1 - Eckl, Rebecca A1 - Blum, Rahel A1 - Müller, Monika ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Genisa-Blätter II N2 - In den acht Beiträgen der „Genisa-Blätter II“ werden Funde aus verschiedenen fränkischen Genisot vorgestellt. Sie wurden im Rahmen eines interdisziplinären Workshops im Genisaprojekt Veitshöchheim von Nachwuchswissenschaftlerinnen und -wissenschaftlern aus ganz Deutschland bearbeitet. Die edierten Quellen sowie deren Einordnung durch die Autorinnen und Autoren geben vielfältige Einblicke in die Komplexität des historischen Judentums in Franken. Der Schwerpunkt dieser Ausgabe liegt auf Text- und Textilfunden aus dem Bereich der Religion. KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102539 SN - 978-3-86956-393-0 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Zhong, Qi A1 - Metwalli, Ezzeldin A1 - Rawolle, Monika A1 - Kaune, Gunar A1 - Bivigou Koumba, Achille Mayelle A1 - Laschewsky, Andre A1 - Papadakis, Christine M. A1 - Cubitt, Robert A1 - Wang, Jiping A1 - Müller-Buschbaum, Peter T1 - Vacuum induced dehydration of swollen poly(methoxy diethylene glycol acrylate) and polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene films probed by in-situ neutron reflectivity JF - Polymer : the international journal for the science and technology of polymers N2 - The isothermal vacuum-induced dehydration of thin films made of poly(methoxy diethylene glycol acrylate) (PMDEGA), which were swollen under ambient conditions, is studied. The dehydration behavior of the homopolymer film as well as of a nanostructured film of the amphiphilic triblock copolymer polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene, abbreviated as PS-b-PMDEGA-b-PS, are probed, and compared to the thermally induced dehydration behavior of such thin thermo-responsive films when they pass through their LCST-type coil-to globule collapse transition. The dehydration kinetics is followed by in-situ neutron reflectivity measurements. Contrast results from the use of deuterated water. Water content and film thickness are significantly reduced during the process, which can be explained by Schott second order kinetics theory for both films. The water content of the dehydrated equilibrium state from this model is very close to the residual water content obtained from the final static measurements, indicating that residual water still remains in the film even after prolonged exposure to the vacuum. In the PS-b-PMDEGA-b-PS film that shows micro-phase separation, the hydrophobic PS domains modify the dehydration process by hindering the water removal, and thus retarding dehydration by about 30%. Whereas residual water remains tightly bound in the PMDEGA domains, water is completely removed from the PS domains of the block copolymer film. (C) 2017 Elsevier Ltd. All rights reserved. KW - Dehydration KW - Vacuum drying KW - In-situ neutron reflectivity Y1 - 2017 U6 - https://doi.org/10.1016/j.polymer.2017.07.066 SN - 0032-3861 SN - 1873-2291 VL - 124 SP - 263 EP - 273 PB - Elsevier CY - Oxford ER - TY - GEN A1 - Sas, Claudia A1 - Müller, Frank A1 - Kappel, Christian A1 - Kent, Tyler V. A1 - Wright, Stephen I. A1 - Hilker, Monika A1 - Lenhard, Michael T1 - Repeated inactivation of the first committed enzyme underlies the loss of benzaldehyde emission after the selfing transition in Capsella T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The enormous species richness of flowering plants is at least partly due to floral diversification driven by interactions between plants and their animal pollinators [1, 2]. Specific pollinator attraction relies on visual and olfactory floral cues [3-5]; floral scent can not only attract pollinators but also attract or repel herbivorous insects [6-8]. However, despite its central role for plant-animal interactions, the genetic control of floral scent production and its evolutionary modification remain incompletely understood [9-13]. Benzenoids are an important class of floral scent compounds that are generated from phenylalanine via several enzymatic pathways [14-17]. Here we address the genetic basis of the loss of floral scent associated with the transition from outbreeding to selfing in the genus Capsella. While the outbreeding C. grandiflora emits benzaldehyde as a major constituent of its floral scent, this has been lost in the selfing C. rubella. We identify the Capsella CNL1 gene encoding cinnamate: CoA ligase as responsible for this variation. Population genetic analysis indicates that CNL1 has been inactivated twice independently in C. rubella via different novel mutations to its coding sequence. Together with a recent study in Petunia [18], this identifies cinnamate: CoA ligase as an evolutionary hotspot for mutations causing the loss of benzenoid scent compounds in association with a shift in the reproductive strategy of Capsella from pollination by insects to self-fertilization. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 904 KW - benzyl alcohol-dehydrogenase KW - floral scent KW - recent speciation KW - petunia flowers KW - genus capsella KW - evolution KW - biosynthesis KW - fragrance KW - purification KW - pollinators KW - benzaldehyde KW - selfing syndrome KW - shepherd’s purse KW - cinnamate:CoA ligase Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-438018 SN - 1866-8372 IS - 904 SP - 3313 EP - 3319 ER - TY - JOUR A1 - Zhong, Qi A1 - Metwalli, Ezzeldin A1 - Rawolle, Monika A1 - Kaune, Gunar A1 - Bivigou Koumba, Achille Mayelle A1 - Laschewsky, Andre A1 - Papadakis, Christine M. A1 - Cubitt, Robert A1 - Wang, Jiping A1 - Müller-Buschbaum, Peter T1 - Influence of Hydrophobic Polystyrene Blocks on the Rehydration of Polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene Films Investigated by in Situ Neutron Reflectivity JF - Macromolecules : a publication of the American Chemical Society N2 - The rehydration of thermoresponsive polystyrene-block-poly(methoxy diethylene glycol acrylate)-block-polystyrene (PS-b-PMDEGA-b-PS) films forming a lamellar microphase-separated structure is investigated by in situ neutron reflectivity in a D2O vapor atmosphere. The rehydration of collapsed PS-b-PMDEGA-b-PS films is realized by a temperature change from 45 to 23 degrees C and comprises (1) condensation and absorption of D2O, (2) evaporation of D2O, and (3) reswelling of the film due to internal rearrangement. The hydrophobic PS layers hinder the absorption of condensed D2O, and a redistribution of embedded D2O between the hydrophobic PS layers and the hydrophilic PMDEGA layers is observed. In contrast, the rehydration of semiswollen PS-b-PMDEGA-b-PS films (temperature change from 35 to 23 degrees C) shows two prominent differences: A thicker D2O layer condenses on the surface, causing a more enhanced evaporation of D2O. The rehydrated films differ in film thickness and volume fraction of D2O, which is due to the different thermal protocols, although the final temperature is identical. Y1 - 2016 U6 - https://doi.org/10.1021/acs.macromol.5b02279 SN - 0024-9297 SN - 1520-5835 VL - 49 SP - 317 EP - 326 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Müller, Monika A1 - Rudolf, Gabi ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Tabaktüten und Zigarettenschachteln BT - Spuren des Tabakkonsums in fränkischen und pfälzischen Genisot JF - Genisa-Blätter KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish studies Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-77334 SP - 109 EP - 124 ER - TY - JOUR A1 - Müller, Monika A1 - Rudolf, Gabi ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Von tödlichen Krankheiten, Totgeburten und Mania Stupita BT - Leichenblätter aus der Altenkunstadter Genisa JF - Genisa-Blätter KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish studies Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-77317 SP - 95 EP - 101 ER - TY - JOUR A1 - Müller, Monika A1 - Sowa, Oliver ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Ein Blick hinter die Schultüre? BT - Französischübungen aus Altenkunstadt JF - Genisa-Blätter KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish studies Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-77357 SP - 135 EP - 143 ER - TY - CHAP A1 - Kurbel, Karl A1 - Nowak, Dawid A1 - Azodi, Amir A1 - Jaeger, David A1 - Meinel, Christoph A1 - Cheng, Feng A1 - Sapegin, Andrey A1 - Gawron, Marian A1 - Morelli, Frank A1 - Stahl, Lukas A1 - Kerl, Stefan A1 - Janz, Mariska A1 - Hadaya, Abdulmasih A1 - Ivanov, Ivaylo A1 - Wiese, Lena A1 - Neves, Mariana A1 - Schapranow, Matthieu-Patrick A1 - Fähnrich, Cindy A1 - Feinbube, Frank A1 - Eberhardt, Felix A1 - Hagen, Wieland A1 - Plauth, Max A1 - Herscheid, Lena A1 - Polze, Andreas A1 - Barkowsky, Matthias A1 - Dinger, Henriette A1 - Faber, Lukas A1 - Montenegro, Felix A1 - Czachórski, Tadeusz A1 - Nycz, Monika A1 - Nycz, Tomasz A1 - Baader, Galina A1 - Besner, Veronika A1 - Hecht, Sonja A1 - Schermann, Michael A1 - Krcmar, Helmut A1 - Wiradarma, Timur Pratama A1 - Hentschel, Christian A1 - Sack, Harald A1 - Abramowicz, Witold A1 - Sokolowska, Wioletta A1 - Hossa, Tymoteusz A1 - Opalka, Jakub A1 - Fabisz, Karol A1 - Kubaczyk, Mateusz A1 - Cmil, Milena A1 - Meng, Tianhui A1 - Dadashnia, Sharam A1 - Niesen, Tim A1 - Fettke, Peter A1 - Loos, Peter A1 - Perscheid, Cindy A1 - Schwarz, Christian A1 - Schmidt, Christopher A1 - Scholz, Matthias A1 - Bock, Nikolai A1 - Piller, Gunther A1 - Böhm, Klaus A1 - Norkus, Oliver A1 - Clark, Brian A1 - Friedrich, Björn A1 - Izadpanah, Babak A1 - Merkel, Florian A1 - Schweer, Ilias A1 - Zimak, Alexander A1 - Sauer, Jürgen A1 - Fabian, Benjamin A1 - Tilch, Georg A1 - Müller, David A1 - Plöger, Sabrina A1 - Friedrich, Christoph M. A1 - Engels, Christoph A1 - Amirkhanyan, Aragats A1 - van der Walt, Estée A1 - Eloff, J. H. P. A1 - Scheuermann, Bernd A1 - Weinknecht, Elisa ED - Meinel, Christoph ED - Polze, Andreas ED - Oswald, Gerhard ED - Strotmann, Rolf ED - Seibold, Ulrich ED - Schulzki, Bernhard T1 - HPI Future SOC Lab BT - Proceedings 2015 N2 - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie. Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt. Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor. KW - Future SOC Lab KW - Forschungsprojekte KW - Multicore Architekturen KW - In-Memory Technologie KW - Cloud Computing KW - maschinelles Lernen KW - künstliche Intelligenz Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516 ER - TY - JOUR A1 - Zhong, Qi A1 - Metwalli, Ezzeldin A1 - Rawolle, Monika A1 - Kaune, Gunar A1 - Bivigou Koumba, Achille Mayelle A1 - Laschewsky, André A1 - Papadakis, Christine M. A1 - Cubitt, Robert A1 - Müller-Buschbaum, Peter T1 - Rehydration of Thermoresponsive Poly(monomethoxydiethylene glycol acrylate) Films Probed in Situ by Real-Time Neutron Reflectivity JF - Macromolecules : a publication of the American Chemical Society N2 - The rehydration of thermoresponsive poly(monomethoxydiethylene glycol acrylate) (PMDEGA) films exhibiting a lower critical solution temperature (LCST) type demixing phase transition in aqueous environments, induced by a decrease in temperature, is investigated in situ with real-time neutron reflectivity. Two different starting conditions (collapsed versus partially swollen chain conformation) are compared. In one experiment, the temperature is reduced from above the demixing temperature to well below the demixing temperature. In a second experiment, the starting temperature is below the demixing temperature, but within the transition regime, and reduced to the same final temperature. In both cases, the observed rehydration process can be divided into three stages: first condensation of water from the surrounding atmosphere, then absorption of water by the PMDEGA film and evaporation of excess water, and finally, rearrangement of the PMDEGA chains. The final rehydrated film is thicker and contains more absorbed water as compared with the initially swollen film at the same temperature well below the demixing temperature. Y1 - 2015 U6 - https://doi.org/10.1021/acs.macromol.5b00645 SN - 0024-9297 SN - 1520-5835 VL - 48 IS - 11 SP - 3604 EP - 3612 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Jedrusik-Bode, Monika A1 - Studencka, Maja A1 - Smolka, Christian A1 - Baumann, Tobias A1 - Schmidt, Henning A1 - Kampf, Jan A1 - Paap, Franziska A1 - Martin, Sophie A1 - Tazi, Jamal A1 - Müller, Kristian M. A1 - Krüger, Marcus A1 - Braun, Thomas A1 - Bober, Eva T1 - The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals JF - Journal of cell science N2 - SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress. KW - C. elegans KW - G3BP KW - SIRT6 KW - Sirtuins KW - Stress KW - Stress granules Y1 - 2013 U6 - https://doi.org/10.1242/jcs.130708 SN - 0021-9533 SN - 1477-9137 VL - 126 IS - 22 SP - 5166 EP - + PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Zhong, Qi A1 - Metwalli, Ezzeldin A1 - Rawolle, Monika A1 - Kaune, Gunar A1 - Bivigou Koumba, Achille Mayelle A1 - Laschewsky, André A1 - Papadakis, Christine M. A1 - Cubitt, Robert A1 - Müller-Buschbaum, Peter T1 - Structure and Thermal Response of Thin Thermoresponsive Polystyrene-block-poly(methoxydiethylene glycol acrylate)-block-polystyrene Films JF - Macromolecules : a publication of the American Chemical Society N2 - Thin thermoresponsive films of the triblock copolymer polystyrene-block-poly(methoxydiethylene glycol acrylate)-block-polystyrene (P(S-b-MDEGA-b-S)) are investigated on silicon substrates. By spin coating, homogeneous and smooth films are prepared for a range of film thicknesses from 6 to 82 nm. Films are stable with respect to dewetting as investigated with optical microscopy and atomic force microscopy. P(S-b-MDEGA-b-S) films with a thickness of 39 nm exhibit a phase transition of the lower critical solution temperature (LCST) type at 36.5 degrees C. The swelling and the thermoresponsive behavior of the films with respect to a sudden thermal stimulus are probed with in-situ neutron reflectivity. In undersaturated water vapor swelling proceeds without thickness increase. The thermoresponse proceeds in three steps: First, the film rejects water as the temperature is above LCST. Next, it stays constant for 600 s, before the collapsed film takes up water again. With ATR-FTIR measurements, changes of bound water in the film caused by different thermal stimuli are studied. Hydrogen bonds only form between C=O and water in the swollen film. Above the LCST most hydrogen bonds with water are broken, but some amount of bound water remains inside the film in agreement with the neutron reflectivity data. Grazing-incidence small-angle X-ray scattering (GISAXS) shows that the inner lateral structure is not significantly influenced by the different thermal stimuli. Y1 - 2013 U6 - https://doi.org/10.1021/ma400627u SN - 0024-9297 VL - 46 IS - 10 SP - 4069 EP - 4080 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Zhong, Qi A1 - Metwalli, Ezzeldin A1 - Kaune, Gunar A1 - Rawolle, Monika A1 - Bivigou Koumba, Achille Mayelle A1 - Laschewsky, André A1 - Papadakis, Christine M. A1 - Cubitt, Robert A1 - Müller-Buschbaum, Peter T1 - Switching kinetics of thin thermo-responsive hydrogel films of poly(monomethoxy-diethyleneglycol-acrylate) probed with in situ neutron reflectivity JF - Soft matter N2 - The switching kinetics of thin thermo-responsive hydrogel films of poly(monomethoxy-diethyleneglycol-acrylate) (PMDEGA) are investigated. Homogeneous and smooth PMDEGA films with a thickness of 35.9 nm are prepared on silicon substrates by spin coating. As probed with white light interferometry, PMDEGA films with a thickness of 35.9 nm exhibit a phase transition temperature of the lower critical solution temperature (LCST) type of 40 degrees C. In situ neutron reflectivity is performed to investigate the thermo-responsive behavior of these PMDEGA hydrogel films in response to a sudden thermal stimulus in deuterated water vapor atmosphere. The collapse transition proceeds in a complex way which can be seen as three steps. The first step is the shrinkage of the initially swollen film by a release of water. In the second step the thickness remains constant with water molecules embedded in the film. In the third step, perhaps due to a conformational rearrangement of the collapsed PMDEGA chains, water is reabsorbed from the vapor atmosphere, thereby giving rise to a relaxation process. Both the shrinkage and relaxation processes can be described by a simple model of hydrogel deswelling. Y1 - 2012 U6 - https://doi.org/10.1039/c2sm25401h SN - 1744-683X VL - 8 IS - 19 SP - 5241 EP - 5249 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Zech, Christina A1 - Stein, Monika A1 - Haberer, Anke A1 - Böhne, Alexander A1 - Müller-Röber, Bernd A1 - Heinig, Angela A1 - Raehse, Sebastian T1 - Portal = Existenzgründung: Ein Sprung ins kalte Wasser BT - Die Potsdamer Universitätszeitung N2 - Aus dem Inhalt: Existenzgründung: Ein Sprung ins kalte Wasser -Bernd Walz über Wettbewerbsfähigkeit und Nachwuchsförderung -Gertrud Lehnert über Mode bei Marcel Proust -Juniorprofessor Jens Eisert über Quanteninformation T3 - Portal: Das Potsdamer Universitätsmagazin - 03-04/2003 Y1 - 2003 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-501536 SN - 1618-6893 VL - 2003 ER - TY - JOUR A1 - Tielbörger, Katja A1 - Kadmon, Ronen A1 - Müller, Monika A1 - Jeltsch, Florian T1 - Populationsdynamische Funktionen von Ausbreitung und Dormanz Y1 - 2000 ER - TY - JOUR A1 - Tielbörger, Katja A1 - Kadmon, Ronen A1 - Müller, Monika A1 - Jeltsch, Florian T1 - Raum-zeitliche Populationsdynamik von einjährigen Wüstenpflanzen Y1 - 2000 ER - TY - JOUR A1 - Heinecke, Margret A1 - Müller, Monika T1 - Vorgabenorientierte Textproduktion als Bestandteil der DSH : Prozeßgestaltung und Produktbewertung ; aktuelle Praxis am Studienkolleg der Universität Potsdam Y1 - 1996 ER -