TY  - JOUR
A1  - Gancheva, Sofiya
A1  - Ouni, Meriem
A1  - Jelenik, Tomas
A1  - Koliaki, Chrysi
A1  - Szendroedi, Julia
A1  - Toledo, Frederico G. S.
A1  - Markgraf, Daniel Frank
A1  - Pesta, Dominik H.
A1  - Mastrototaro, Lucia
A1  - De Filippo, Elisabetta
A1  - Herder, Christian
A1  - Jähnert, Markus
A1  - Weiss, Jürgen
A1  - Strassburger, Klaus
A1  - Schlensak, Matthias
A1  - Schürmann, Annette
A1  - Roden, Michael
T1  - Dynamic changes of muscle insulin sensitivity after metabolic surgery
JF  - Nature Communications
N2  - The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity.
Y1  - 2019
U6  - https://doi.org/10.1038/s41467-019-12081-0
SN  - 2041-1723
VL  - 10
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Schwerbel, Kristin
A1  - Kamitz, Anne
A1  - Jaehnert, Markus
A1  - Gottmann, P.
A1  - Schumacher, Fabian
A1  - Kleuser, Burkhard
A1  - Haltenhof, T.
A1  - Heyd, F.
A1  - Roden, Michael
A1  - Chadt, Alexandra
A1  - Al-Hasani, Hadi
A1  - Jonas, W.
A1  - Vogel, Heike
A1  - Schürmann, Annette
T1  - Two immune-related GTPases prevent from hepatic fat accumulation by inducing autophagy
T2  - Diabetologia : journal of the European Association for the Study of Diabetes (EASD)
Y1  - 2018
SN  - 0012-186X
SN  - 1432-0428
VL  - 61
SP  - S259
EP  - S259
PB  - Springer
CY  - New York
ER  -