TY - JOUR A1 - Aarts, Alexander A. A1 - Anderson, Joanna E. A1 - Anderson, Christopher J. A1 - Attridge, Peter R. A1 - Attwood, Angela A1 - Axt, Jordan A1 - Babel, Molly A1 - Bahnik, Stepan A1 - Baranski, Erica A1 - Barnett-Cowan, Michael A1 - Bartmess, Elizabeth A1 - Beer, Jennifer A1 - Bell, Raoul A1 - Bentley, Heather A1 - Beyan, Leah A1 - Binion, Grace A1 - Borsboom, Denny A1 - Bosch, Annick A1 - Bosco, Frank A. A1 - Bowman, Sara D. A1 - Brandt, Mark J. A1 - Braswell, Erin A1 - Brohmer, Hilmar A1 - Brown, Benjamin T. A1 - Brown, Kristina A1 - Bruening, Jovita A1 - Calhoun-Sauls, Ann A1 - Callahan, Shannon P. A1 - Chagnon, Elizabeth A1 - Chandler, Jesse A1 - Chartier, Christopher R. A1 - Cheung, Felix A1 - Christopherson, Cody D. A1 - Cillessen, Linda A1 - Clay, Russ A1 - Cleary, Hayley A1 - Cloud, Mark D. A1 - Cohn, Michael A1 - Cohoon, Johanna A1 - Columbus, Simon A1 - Cordes, Andreas A1 - Costantini, Giulio A1 - Alvarez, Leslie D. Cramblet A1 - Cremata, Ed A1 - Crusius, Jan A1 - DeCoster, Jamie A1 - DeGaetano, Michelle A. A1 - Della Penna, Nicolas A1 - den Bezemer, Bobby A1 - Deserno, Marie K. A1 - Devitt, Olivia A1 - Dewitte, Laura A1 - Dobolyi, David G. A1 - Dodson, Geneva T. A1 - Donnellan, M. Brent A1 - Donohue, Ryan A1 - Dore, Rebecca A. A1 - Dorrough, Angela A1 - Dreber, Anna A1 - Dugas, Michelle A1 - Dunn, Elizabeth W. A1 - Easey, Kayleigh A1 - Eboigbe, Sylvia A1 - Eggleston, Casey A1 - Embley, Jo A1 - Epskamp, Sacha A1 - Errington, Timothy M. A1 - Estel, Vivien A1 - Farach, Frank J. A1 - Feather, Jenelle A1 - Fedor, Anna A1 - Fernandez-Castilla, Belen A1 - Fiedler, Susann A1 - Field, James G. A1 - Fitneva, Stanka A. A1 - Flagan, Taru A1 - Forest, Amanda L. A1 - Forsell, Eskil A1 - Foster, Joshua D. A1 - Frank, Michael C. A1 - Frazier, Rebecca S. A1 - Fuchs, Heather A1 - Gable, Philip A1 - Galak, Jeff A1 - Galliani, Elisa Maria A1 - Gampa, Anup A1 - Garcia, Sara A1 - Gazarian, Douglas A1 - Gilbert, Elizabeth A1 - Giner-Sorolla, Roger A1 - Glöckner, Andreas A1 - Göllner, Lars A1 - Goh, Jin X. A1 - Goldberg, Rebecca A1 - Goodbourn, Patrick T. A1 - Gordon-McKeon, Shauna A1 - Gorges, Bryan A1 - Gorges, Jessie A1 - Goss, Justin A1 - Graham, Jesse A1 - Grange, James A. A1 - Gray, Jeremy A1 - Hartgerink, Chris A1 - Hartshorne, Joshua A1 - Hasselman, Fred A1 - Hayes, Timothy A1 - Heikensten, Emma A1 - Henninger, Felix A1 - Hodsoll, John A1 - Holubar, Taylor A1 - Hoogendoorn, Gea A1 - Humphries, Denise J. A1 - Hung, Cathy O. -Y. A1 - Immelman, Nathali A1 - Irsik, Vanessa C. A1 - Jahn, Georg A1 - Jaekel, Frank A1 - Jekel, Marc A1 - Johannesson, Magnus A1 - Johnson, Larissa G. A1 - Johnson, David J. A1 - Johnson, Kate M. A1 - Johnston, William J. A1 - Jonas, Kai A1 - Joy-Gaba, Jennifer A. A1 - Kappes, Heather Barry A1 - Kelso, Kim A1 - Kidwell, Mallory C. A1 - Kim, Seung Kyung A1 - Kirkhart, Matthew A1 - Kleinberg, Bennett A1 - Knezevic, Goran A1 - Kolorz, Franziska Maria A1 - Kossakowski, Jolanda J. A1 - Krause, Robert Wilhelm A1 - Krijnen, Job A1 - Kuhlmann, Tim A1 - Kunkels, Yoram K. A1 - Kyc, Megan M. A1 - Lai, Calvin K. A1 - Laique, Aamir A1 - Lakens, Daniel A1 - Lane, Kristin A. A1 - Lassetter, Bethany A1 - Lazarevic, Ljiljana B. A1 - LeBel, Etienne P. A1 - Lee, Key Jung A1 - Lee, Minha A1 - Lemm, Kristi A1 - Levitan, Carmel A. A1 - Lewis, Melissa A1 - Lin, Lin A1 - Lin, Stephanie A1 - Lippold, Matthias A1 - Loureiro, Darren A1 - Luteijn, Ilse A1 - Mackinnon, Sean A1 - Mainard, Heather N. A1 - Marigold, Denise C. A1 - Martin, Daniel P. A1 - Martinez, Tylar A1 - Masicampo, E. J. A1 - Matacotta, Josh A1 - Mathur, Maya A1 - May, Michael A1 - Mechin, Nicole A1 - Mehta, Pranjal A1 - Meixner, Johannes A1 - Melinger, Alissa A1 - Miller, Jeremy K. A1 - Miller, Mallorie A1 - Moore, Katherine A1 - Möschl, Marcus A1 - Motyl, Matt A1 - Müller, Stephanie M. A1 - Munafo, Marcus A1 - Neijenhuijs, Koen I. A1 - Nervi, Taylor A1 - Nicolas, Gandalf A1 - Nilsonne, Gustav A1 - Nosek, Brian A. A1 - Nuijten, Michele B. A1 - Olsson, Catherine A1 - Osborne, Colleen A1 - Ostkamp, Lutz A1 - Pavel, Misha A1 - Penton-Voak, Ian S. A1 - Perna, Olivia A1 - Pernet, Cyril A1 - Perugini, Marco A1 - Pipitone, R. Nathan A1 - Pitts, Michael A1 - Plessow, Franziska A1 - Prenoveau, Jason M. A1 - Rahal, Rima-Maria A1 - Ratliff, Kate A. A1 - Reinhard, David A1 - Renkewitz, Frank A1 - Ricker, Ashley A. A1 - Rigney, Anastasia A1 - Rivers, Andrew M. A1 - Roebke, Mark A1 - Rutchick, Abraham M. A1 - Ryan, Robert S. A1 - Sahin, Onur A1 - Saide, Anondah A1 - Sandstrom, Gillian M. A1 - Santos, David A1 - Saxe, Rebecca A1 - Schlegelmilch, Rene A1 - Schmidt, Kathleen A1 - Scholz, Sabine A1 - Seibel, Larissa A1 - Selterman, Dylan Faulkner A1 - Shaki, Samuel A1 - Simpson, William B. A1 - Sinclair, H. Colleen A1 - Skorinko, Jeanine L. M. A1 - Slowik, Agnieszka A1 - Snyder, Joel S. A1 - Soderberg, Courtney A1 - Sonnleitner, Carina A1 - Spencer, Nick A1 - Spies, Jeffrey R. A1 - Steegen, Sara A1 - Stieger, Stefan A1 - Strohminger, Nina A1 - Sullivan, Gavin B. A1 - Talhelm, Thomas A1 - Tapia, Megan A1 - te Dorsthorst, Anniek A1 - Thomae, Manuela A1 - Thomas, Sarah L. A1 - Tio, Pia A1 - Traets, Frits A1 - Tsang, Steve A1 - Tuerlinckx, Francis A1 - Turchan, Paul A1 - Valasek, Milan A1 - Van Aert, Robbie A1 - van Assen, Marcel A1 - van Bork, Riet A1 - van de Ven, Mathijs A1 - van den Bergh, Don A1 - van der Hulst, Marije A1 - van Dooren, Roel A1 - van Doorn, Johnny A1 - van Renswoude, Daan R. A1 - van Rijn, Hedderik A1 - Vanpaemel, Wolf A1 - Echeverria, Alejandro Vasquez A1 - Vazquez, Melissa A1 - Velez, Natalia A1 - Vermue, Marieke A1 - Verschoor, Mark A1 - Vianello, Michelangelo A1 - Voracek, Martin A1 - Vuu, Gina A1 - Wagenmakers, Eric-Jan A1 - Weerdmeester, Joanneke A1 - Welsh, Ashlee A1 - Westgate, Erin C. A1 - Wissink, Joeri A1 - Wood, Michael A1 - Woods, Andy A1 - Wright, Emily A1 - Wu, Sining A1 - Zeelenberg, Marcel A1 - Zuni, Kellylynn T1 - Estimating the reproducibility of psychological science JF - Science N2 - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams. Y1 - 2015 U6 - https://doi.org/10.1126/science.aac4716 SN - 1095-9203 SN - 0036-8075 VL - 349 IS - 6251 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Wuttke, Matthias A1 - Li, Yong A1 - Li, Man A1 - Sieber, Karsten B. A1 - Feitosa, Mary F. A1 - Gorski, Mathias A1 - Tin, Adrienne A1 - Wang, Lihua A1 - Chu, Audrey Y. A1 - Hoppmann, Anselm A1 - Kirsten, Holger A1 - Giri, Ayush A1 - Chai, Jin-Fang A1 - Sveinbjornsson, Gardar A1 - Tayo, Bamidele O. A1 - Nutile, Teresa A1 - Fuchsberger, Christian A1 - Marten, Jonathan A1 - Cocca, Massimiliano A1 - Ghasemi, Sahar A1 - Xu, Yizhe A1 - Horn, Katrin A1 - Noce, Damia A1 - Van der Most, Peter J. A1 - Sedaghat, Sanaz A1 - Yu, Zhi A1 - Akiyama, Masato A1 - Afaq, Saima A1 - Ahluwalia, Tarunveer Singh A1 - Almgren, Peter A1 - Amin, Najaf A1 - Arnlov, Johan A1 - Bakker, Stephan J. L. A1 - Bansal, Nisha A1 - Baptista, Daniela A1 - Bergmann, Sven A1 - Biggs, Mary L. A1 - Biino, Ginevra A1 - Boehnke, Michael A1 - Boerwinkle, Eric A1 - Boissel, Mathilde A1 - Böttinger, Erwin A1 - Boutin, Thibaud S. A1 - Brenner, Hermann A1 - Brumat, Marco A1 - Burkhardt, Ralph A1 - Butterworth, Adam S. A1 - Campana, Eric A1 - Campbell, Archie A1 - Campbell, Harry A1 - Canouil, Mickael A1 - Carroll, Robert J. A1 - Catamo, Eulalia A1 - Chambers, John C. A1 - Chee, Miao-Ling A1 - Chee, Miao-Li A1 - Chen, Xu A1 - Cheng, Ching-Yu A1 - Cheng, Yurong A1 - Christensen, Kaare A1 - Cifkova, Renata A1 - Ciullo, Marina A1 - Concas, Maria Pina A1 - Cook, James P. A1 - Coresh, Josef A1 - Corre, Tanguy A1 - Sala, Cinzia Felicita A1 - Cusi, Daniele A1 - Danesh, John A1 - Daw, E. Warwick A1 - De Borst, Martin H. A1 - De Grandi, Alessandro A1 - De Mutsert, Renee A1 - De Vries, Aiko P. J. A1 - Degenhardt, Frauke A1 - Delgado, Graciela A1 - Demirkan, Ayse A1 - Di Angelantonio, Emanuele A1 - Dittrich, Katalin A1 - Divers, Jasmin A1 - Dorajoo, Rajkumar A1 - Eckardt, Kai-Uwe A1 - Ehret, Georg A1 - Elliott, Paul A1 - Endlich, Karlhans A1 - Evans, Michele K. A1 - Felix, Janine F. A1 - Foo, Valencia Hui Xian A1 - Franco, Oscar H. A1 - Franke, Andre A1 - Freedman, Barry I. A1 - Freitag-Wolf, Sandra A1 - Friedlander, Yechiel A1 - Froguel, Philippe A1 - Gansevoort, Ron T. A1 - Gao, He A1 - Gasparini, Paolo A1 - Gaziano, J. Michael A1 - Giedraitis, Vilmantas A1 - Gieger, Christian A1 - Girotto, Giorgia A1 - Giulianini, Franco A1 - Gogele, Martin A1 - Gordon, Scott D. A1 - Gudbjartsson, Daniel F. A1 - Gudnason, Vilmundur A1 - Haller, Toomas A1 - Hamet, Pavel A1 - Harris, Tamara B. A1 - Hartman, Catharina A. A1 - Hayward, Caroline A1 - Hellwege, Jacklyn N. A1 - Heng, Chew-Kiat A1 - Hicks, Andrew A. A1 - Hofer, Edith A1 - Huang, Wei A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Indridason, Olafur S. A1 - Ingelsson, Erik A1 - Ising, Marcus A1 - Jaddoe, Vincent W. V. A1 - Jakobsdottir, Johanna A1 - Jonas, Jost B. A1 - Joshi, Peter K. A1 - Josyula, Navya Shilpa A1 - Jung, Bettina A1 - Kahonen, Mika A1 - Kamatani, Yoichiro A1 - Kammerer, Candace M. A1 - Kanai, Masahiro A1 - Kastarinen, Mika A1 - Kerr, Shona M. A1 - Khor, Chiea-Chuen A1 - Kiess, Wieland A1 - Kleber, Marcus E. A1 - Koenig, Wolfgang A1 - Kooner, Jaspal S. A1 - Korner, Antje A1 - Kovacs, Peter A1 - Kraja, Aldi T. A1 - Krajcoviechova, Alena A1 - Kramer, Holly A1 - Kramer, Bernhard K. A1 - Kronenberg, Florian A1 - Kubo, Michiaki A1 - Kuhnel, Brigitte A1 - Kuokkanen, Mikko A1 - Kuusisto, Johanna A1 - La Bianca, Martina A1 - Laakso, Markku A1 - Lange, Leslie A. A1 - Langefeld, Carl D. A1 - Lee, Jeannette Jen-Mai A1 - Lehne, Benjamin A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Lim, Su-Chi A1 - Lind, Lars A1 - Lindgren, Cecilia M. A1 - Liu, Jun A1 - Liu, Jianjun A1 - Loeffler, Markus A1 - Loos, Ruth J. F. A1 - Lucae, Susanne A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Magi, Reedik A1 - Magnusson, Patrik K. E. A1 - Mahajan, Anubha A1 - Martin, Nicholas G. A1 - Martins, Jade A1 - Marz, Winfried A1 - Mascalzoni, Deborah A1 - Matsuda, Koichi A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Metspalu, Andres A1 - Mikaelsdottir, Evgenia K. A1 - Milaneschi, Yuri A1 - Miliku, Kozeta A1 - Mishra, Pashupati P. A1 - Program, V. A. Million Veteran A1 - Mohlke, Karen L. A1 - Mononen, Nina A1 - Montgomery, Grant W. A1 - Mook-Kanamori, Dennis O. A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nalls, Mike A. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - Noordam, Raymond A1 - Olafsson, Isleifur A1 - Oldehinkel, Albertine J. A1 - Orho-Melander, Marju A1 - Ouwehand, Willem H. A1 - Padmanabhan, Sandosh A1 - Palmer, Nicholette D. A1 - Palsson, Runolfur A1 - Penninx, Brenda W. J. H. A1 - Perls, Thomas A1 - Perola, Markus A1 - Pirastu, Mario A1 - Pirastu, Nicola A1 - Pistis, Giorgio A1 - Podgornaia, Anna I. A1 - Polasek, Ozren A1 - Ponte, Belen A1 - Porteous, David J. A1 - Poulain, Tanja A1 - Pramstaller, Peter P. A1 - Preuss, Michael H. A1 - Prins, Bram P. A1 - Province, Michael A. A1 - Rabelink, Ton J. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Reilly, Dermot F. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Ridker, Paul M. A1 - Rivadeneira, Fernando A1 - Rizzi, Federica A1 - Roberts, David J. A1 - Robino, Antonietta A1 - Rossing, Peter A1 - Rudan, Igor A1 - Rueedi, Rico A1 - Ruggiero, Daniela A1 - Ryan, Kathleen A. A1 - Saba, Yasaman A1 - Sabanayagam, Charumathi A1 - Salomaa, Veikko A1 - Salvi, Erika A1 - Saum, Kai-Uwe A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Ben Schottker, A1 - Schulz, Christina-Alexandra A1 - Schupf, Nicole A1 - Shaffer, Christian M. A1 - Shi, Yuan A1 - Smith, Albert V. A1 - Smith, Blair H. A1 - Soranzo, Nicole A1 - Spracklen, Cassandra N. A1 - Strauch, Konstantin A1 - Stringham, Heather M. A1 - Stumvoll, Michael A1 - Svensson, Per O. A1 - Szymczak, Silke A1 - Tai, E-Shyong A1 - Tajuddin, Salman M. A1 - Tan, Nicholas Y. Q. A1 - Taylor, Kent D. A1 - Teren, Andrej A1 - Tham, Yih-Chung A1 - Thiery, Joachim A1 - Thio, Chris H. L. A1 - Thomsen, Hauke A1 - Thorleifsson, Gudmar A1 - Toniolo, Daniela A1 - Tonjes, Anke A1 - Tremblay, Johanne A1 - Tzoulaki, Ioanna A1 - Uitterlinden, Andre G. A1 - Vaccargiu, Simona A1 - Van Dam, Rob M. A1 - Van der Harst, Pim A1 - Van Duijn, Cornelia M. A1 - Edward, Digna R. Velez A1 - Verweij, Niek A1 - Vogelezang, Suzanne A1 - Volker, Uwe A1 - Vollenweider, Peter A1 - Waeber, Gerard A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Wang, Ya Xing A1 - Wang, Chaolong A1 - Waterworth, Dawn M. A1 - Bin Wei, Wen A1 - White, Harvey A1 - Whitfield, John B. A1 - Wild, Sarah H. A1 - Wilson, James F. A1 - Wojczynski, Mary K. A1 - Wong, Charlene A1 - Wong, Tien-Yin A1 - Xu, Liang A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Weihua A1 - Zonderman, Alan B. A1 - Rotter, Jerome I. A1 - Bochud, Murielle A1 - Psaty, Bruce M. A1 - Vitart, Veronique A1 - Wilson, James G. A1 - Dehghan, Abbas A1 - Parsa, Afshin A1 - Chasman, Daniel I. A1 - Ho, Kevin A1 - Morris, Andrew P. A1 - Devuyst, Olivier A1 - Akilesh, Shreeram A1 - Pendergrass, Sarah A. A1 - Sim, Xueling A1 - Boger, Carsten A. A1 - Okada, Yukinori A1 - Edwards, Todd L. A1 - Snieder, Harold A1 - Stefansson, Kari A1 - Hung, Adriana M. A1 - Heid, Iris M. A1 - Scholz, Markus A1 - Teumer, Alexander A1 - Kottgen, Anna A1 - Pattaro, Cristian T1 - A catalog of genetic loci associated with kidney function from analyses of a million individuals JF - Nature genetics N2 - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research. Y1 - 2019 U6 - https://doi.org/10.1038/s41588-019-0407-x SN - 1061-4036 SN - 1546-1718 VL - 51 IS - 6 SP - 957 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Thomas, Jessica E. A1 - Carvalho, Gary R. A1 - Haile, James A1 - Rawlence, Nicolas J. A1 - Martin, Michael D. A1 - Ho, Simon Y. W. A1 - Sigfusson, Arnor P. A1 - Josefsson, Vigfus A. A1 - Frederiksen, Morten A1 - Linnebjerg, Jannie F. A1 - Castruita, Jose A. Samaniego A1 - Niemann, Jonas A1 - Sinding, Mikkel-Holger S. A1 - Sandoval-Velasco, Marcela A1 - Soares, Andre E. R. A1 - Lacy, Robert A1 - Barilaro, Christina A1 - Best, Juila A1 - Brandis, Dirk A1 - Cavallo, Chiara A1 - Elorza, Mikelo A1 - Garrett, Kimball L. A1 - Groot, Maaike A1 - Johansson, Friederike A1 - Lifjeld, Jan T. A1 - Nilson, Goran A1 - Serjeanston, Dale A1 - Sweet, Paul A1 - Fuller, Errol A1 - Hufthammer, Anne Karin A1 - Meldgaard, Morten A1 - Fjeldsa, Jon A1 - Shapiro, Beth A1 - Hofreiter, Michael A1 - Stewart, John R. A1 - Gilbert, M. Thomas P. A1 - Knapp, Michael T1 - Demographic reconstruction from ancient DNA supports rapid extinction of the great auk JF - eLife N2 - The great auk was once abundant and distributed across the North Atlantic. It is now extinct, having been heavily exploited for its eggs, meat, and feathers. We investigated the impact of human hunting on its demise by integrating genetic data, GPS-based ocean current data, and analyses of population viability. We sequenced complete mitochondrial genomes of 41 individuals from across the species' geographic range and reconstructed population structure and population dynamics throughout the Holocene. Taken together, our data do not provide any evidence that great auks were at risk of extinction prior to the onset of intensive human hunting in the early 16th century. In addition, our population viability analyses reveal that even if the great auk had not been under threat by environmental change, human hunting alone could have been sufficient to cause its extinction. Our results emphasise the vulnerability of even abundant and widespread species to intense and localised exploitation. Y1 - 2019 U6 - https://doi.org/10.7554/eLife.47509 SN - 2050-084X VL - 8 PB - eLife Sciences Publications CY - Cambridge ER - TY - JOUR A1 - Warrington, Nicole A1 - Beaumont, Robin A1 - Horikoshi, Momoko A1 - Day, Felix R. A1 - Helgeland, Øyvind A1 - Laurin, Charles A1 - Bacelis, Jonas A1 - Peng, Shouneng A1 - Hao, Ke A1 - Feenstra, Bjarke A1 - Wood, Andrew R. A1 - Mahajan, Anubha A1 - Tyrrell, Jessica A1 - Robertson, Neil R. A1 - Rayner, N. William A1 - Qiao, Zhen A1 - Moen, Gunn-Helen A1 - Vaudel, Marc A1 - Marsit, Carmen A1 - Chen, Jia A1 - Nodzenski, Michael A1 - Schnurr, Theresia M. A1 - Zafarmand, Mohammad Hadi A1 - Bradfield, Jonathan P. A1 - Grarup, Niels A1 - Kooijman, Marjolein N. A1 - Li-Gao, Ruifang A1 - Geller, Frank A1 - Ahluwalia, Tarunveer Singh A1 - Paternoster, Lavinia A1 - Rueedi, Rico A1 - Huikari, Ville A1 - Hottenga, Jouke-Jan A1 - Lyytikäinen, Leo-Pekka A1 - Cavadino, Alana A1 - Metrustry, Sarah A1 - Cousminer, Diana L. A1 - Wu, Ying A1 - Thiering, Elisabeth Paula A1 - Wang, Carol A. A1 - Have, Christian Theil A1 - Vilor-Tejedor, Natalia A1 - Joshi, Peter K. A1 - Painter, Jodie N. A1 - Ntalla, Ioanna A1 - Myhre, Ronny A1 - Pitkänen, Niina A1 - van Leeuwen, Elisabeth M. A1 - Joro, Raimo A1 - Lagou, Vasiliki A1 - Richmond, Rebecca C. A1 - Espinosa, Ana A1 - Barton, Sheila J. A1 - Inskip, Hazel M. A1 - Holloway, John W. A1 - Santa-Marina, Loreto A1 - Estivill, Xavier A1 - Ang, Wei A1 - Marsh, Julie A. A1 - Reichetzeder, Christoph A1 - Marullo, Letizia A1 - Hocher, Berthold A1 - Lunetta, Kathryn L. A1 - Murabito, Joanne M. A1 - Relton, Caroline L. A1 - Kogevinas, Manolis A1 - Chatzi, Leda A1 - Allard, Catherine A1 - Bouchard, Luigi A1 - Hivert, Marie-France A1 - Zhang, Ge A1 - Muglia, Louis J. A1 - Heikkinen, Jani A1 - Morgen, Camilla S. A1 - van Kampen, Antoine H. C. A1 - van Schaik, Barbera D. C. A1 - Mentch, Frank D. A1 - Langenberg, Claudia A1 - Scott, Robert A. A1 - Zhao, Jing Hua A1 - Hemani, Gibran A1 - Ring, Susan M. A1 - Bennett, Amanda J. A1 - Gaulton, Kyle J. A1 - Fernandez-Tajes, Juan A1 - van Zuydam, Natalie R. A1 - Medina-Gomez, Carolina A1 - de Haan, Hugoline G. A1 - Rosendaal, Frits R. A1 - Kutalik, Zoltán A1 - Marques-Vidal, Pedro A1 - Das, Shikta A1 - Willemsen, Gonneke A1 - Mbarek, Hamdi A1 - Müller-Nurasyid, Martina A1 - Standl, Marie A1 - Appel, Emil V. R. A1 - Fonvig, Cilius Esmann A1 - Trier, Caecilie A1 - van Beijsterveldt, Catharina E. M. A1 - Murcia, Mario A1 - Bustamante, Mariona A1 - Bonàs-Guarch, Sílvia A1 - Hougaard, David M. A1 - Mercader, Josep M. A1 - Linneberg, Allan A1 - Schraut, Katharina E. A1 - Lind, Penelope A. A1 - Medland, Sarah Elizabeth A1 - Shields, Beverley M. A1 - Knight, Bridget A. A1 - Chai, Jin-Fang A1 - Panoutsopoulou, Kalliope A1 - Bartels, Meike A1 - Sánchez, Friman A1 - Stokholm, Jakob A1 - Torrents, David A1 - Vinding, Rebecca K. A1 - Willems, Sara M. A1 - Atalay, Mustafa A1 - Chawes, Bo L. A1 - Kovacs, Peter A1 - Prokopenko, Inga A1 - Tuke, Marcus A. A1 - Yaghootkar, Hanieh A1 - Ruth, Katherine S. A1 - Jones, Samuel E. A1 - Loh, Po-Ru A1 - Murray, Anna A1 - Weedon, Michael N. A1 - Tönjes, Anke A1 - Stumvoll, Michael A1 - Michaelsen, Kim Fleischer A1 - Eloranta, Aino-Maija A1 - Lakka, Timo A. A1 - van Duijn, Cornelia M. A1 - Kiess, Wieland A1 - Koerner, Antje A1 - Niinikoski, Harri A1 - Pahkala, Katja A1 - Raitakari, Olli T. A1 - Jacobsson, Bo A1 - Zeggini, Eleftheria A1 - Dedoussis, George V. A1 - Teo, Yik-Ying A1 - Saw, Seang-Mei A1 - Montgomery, Grant W. A1 - Campbell, Harry A1 - Wilson, James F. A1 - Vrijkotte, Tanja G. M. A1 - Vrijheid, Martine A1 - de Geus, Eco J. C. N. A1 - Hayes, M. Geoffrey A1 - Kadarmideen, Haja N. A1 - Holm, Jens-Christian A1 - Beilin, Lawrence J. A1 - Pennell, Craig E. A1 - Heinrich, Joachim A1 - Adair, Linda S. A1 - Borja, Judith B. A1 - Mohlke, Karen L. A1 - Eriksson, Johan G. A1 - Widen, Elisabeth E. A1 - Hattersley, Andrew T. A1 - Spector, Tim D. A1 - Kaehoenen, Mika A1 - Viikari, Jorma S. A1 - Lehtimaeki, Terho A1 - Boomsma, Dorret I. A1 - Sebert, Sylvain A1 - Vollenweider, Peter A1 - Sorensen, Thorkild I. A. A1 - Bisgaard, Hans A1 - Bonnelykke, Klaus A1 - Murray, Jeffrey C. A1 - Melbye, Mads A1 - Nohr, Ellen A. A1 - Mook-Kanamori, Dennis O. A1 - Rivadeneira, Fernando A1 - Hofman, Albert A1 - Felix, Janine F. A1 - Jaddoe, Vincent W. V. A1 - Hansen, Torben A1 - Pisinger, Charlotta A1 - Vaag, Allan A. A1 - Pedersen, Oluf A1 - Uitterlinden, Andre G. A1 - Jarvelin, Marjo-Riitta A1 - Power, Christine A1 - Hypponen, Elina A1 - Scholtens, Denise M. A1 - Lowe, William L. A1 - Smith, George Davey A1 - Timpson, Nicholas J. A1 - Morris, Andrew P. A1 - Wareham, Nicholas J. A1 - Hakonarson, Hakon A1 - Grant, Struan F. A. A1 - Frayling, Timothy M. A1 - Lawlor, Debbie A. A1 - Njolstad, Pal R. A1 - Johansson, Stefan A1 - Ong, Ken K. A1 - McCarthy, Mark I. A1 - Perry, John R. B. A1 - Evans, David M. A1 - Freathy, Rachel M. T1 - Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors JF - Nature genetics N2 - Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming. Y1 - 2019 SN - 1061-4036 SN - 1546-1718 VL - 51 IS - 5 SP - 804 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Thomas, Jessica E. A1 - Carvalho, Gary R. A1 - Haile, James A1 - Martin, Michael D. A1 - Castruita, Jose A. Samaniego A1 - Niemann, Jonas A1 - Sinding, Mikkel-Holger S. A1 - Sandoval-Velasco, Marcela A1 - Rawlence, Nicolas J. A1 - Fuller, Errol A1 - Fjeldsa, Jon A1 - Hofreiter, Michael A1 - Stewart, John R. A1 - Gilbert, M. Thomas P. A1 - Knapp, Michael T1 - An ‛Aukward’ tale BT - a genetic approach to discover the whereabouts of the Last Great Auks JF - Genes N2 - One hundred and seventy-three years ago, the last two Great Auks, Pinguinus impennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the location of their skins has remained a mystery. In 1999, Great Auk expert Errol Fuller proposed a list of five potential candidate skins in museums around the world. Here we take a palaeogenomic approach to test which—if any—of Fuller’s candidate skins likely belong to either of the two birds. Using mitochondrial genomes from the five candidate birds (housed in museums in Bremen, Brussels, Kiel, Los Angeles, and Oldenburg) and the organs of the last two known individuals, we partially solve the mystery that has been on Great Auk scholars’ minds for generations and make new suggestions as to the whereabouts of the still-missing skin from these two birds. KW - ancient DNA KW - extinct birds KW - mitochondrial genome KW - museum specimens KW - palaeogenomics Y1 - 2017 U6 - https://doi.org/10.3390/genes8060164 SN - 2073-4425 VL - 8 IS - 6 SP - 164 PB - MDPI CY - Basel ER - TY - BOOK A1 - Alnemr, Rehab A1 - Polyvyanyy, Artem A1 - AbuJarour, Mohammed A1 - Appeltauer, Malte A1 - Hildebrandt, Dieter A1 - Thomas, Ivonne A1 - Overdick, Hagen A1 - Schöbel, Michael A1 - Uflacker, Matthias A1 - Kluth, Stephan A1 - Menzel, Michael A1 - Schmidt, Alexander A1 - Hagedorn, Benjamin A1 - Pascalau, Emilian A1 - Perscheid, Michael A1 - Vogel, Thomas A1 - Hentschel, Uwe A1 - Feinbube, Frank A1 - Kowark, Thomas A1 - Trümper, Jonas A1 - Vogel, Tobias A1 - Becker, Basil ED - Meinel, Christoph ED - Plattner, Hasso ED - Döllner, Jürgen Roland Friedrich ED - Weske, Mathias ED - Polze, Andreas ED - Hirschfeld, Robert ED - Naumann, Felix ED - Giese, Holger T1 - Proceedings of the 4th Ph.D. Retreat of the HPI Research School on Service-oriented Systems Engineering T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 31 KW - Hasso-Plattner-Institut KW - Forschungskolleg KW - Klausurtagung KW - Service-oriented Systems Engineering KW - Hasso Plattner Institute KW - Research School KW - Ph.D. Retreat KW - Service-oriented Systems Engineering Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-40838 SN - 978-3-86956-036-6 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - CHAP A1 - Curzon, Paul A1 - Kalas, Ivan A1 - Schubert, Sigrid A1 - Schaper, Niclas A1 - Barnes, Jan A1 - Kennewell, Steve A1 - Bröker, Kathrin A1 - Kastens, Uwe A1 - Magenheim, Johannes A1 - Dagiene, Valentina A1 - Stupuriene, Gabriele A1 - Ellis, Jason Brent A1 - Abreu-Ellis, Carla Reis A1 - Grillenberger, Andreas A1 - Romeike, Ralf A1 - Haugsbakken, Halvdan A1 - Jones, Anthony A1 - Lewin, Cathy A1 - McNicol, Sarah A1 - Nelles, Wolfgang A1 - Neugebauer, Jonas A1 - Ohrndorf, Laura A1 - Schaper, Niclas A1 - Schubert, Sigrid A1 - Opel, Simone A1 - Kramer, Matthias A1 - Trommen, Michael A1 - Pottbäcker, Florian A1 - Ilaghef, Youssef A1 - Passig, David A1 - Tzuriel, David A1 - Kedmi, Ganit Eshel A1 - Saito, Toshinori A1 - Webb, Mary A1 - Weigend, Michael A1 - Bottino, Rosa A1 - Chioccariello, Augusto A1 - Christensen, Rhonda A1 - Knezek, Gerald A1 - Gioko, Anthony Maina A1 - Angondi, Enos Kiforo A1 - Waga, Rosemary A1 - Ohrndorf, Laura A1 - Or-Bach, Rachel A1 - Preston, Christina A1 - Younie, Sarah A1 - Przybylla, Mareen A1 - Romeike, Ralf A1 - Reynolds, Nicholas A1 - Swainston, Andrew A1 - Bendrups, Faye A1 - Sysło, Maciej M. A1 - Kwiatkowska, Anna Beata A1 - Zieris, Holger A1 - Gerstberger, Herbert A1 - Müller, Wolfgang A1 - Büchner, Steffen A1 - Opel, Simone A1 - Schiller, Thomas A1 - Wegner, Christian A1 - Zender, Raphael A1 - Lucke, Ulrike A1 - Diethelm, Ira A1 - Syrbe, Jörn A1 - Lai, Kwok-Wing A1 - Davis, Niki A1 - Eickelmann, Birgit A1 - Erstad, Ola A1 - Fisser, Petra A1 - Gibson, David A1 - Khaddage, Ferial A1 - Knezek, Gerald A1 - Micheuz, Peter A1 - Kloos, Carlos Delgado ED - Brinda, Torsten ED - Reynolds, Nicholas ED - Romeike, Ralf ED - Schwill, Andreas T1 - KEYCIT 2014 BT - key competencies in informatics and ICT N2 - In our rapidly changing world it is increasingly important not only to be an expert in a chosen field of study but also to be able to respond to developments, master new approaches to solving problems, and fulfil changing requirements in the modern world and in the job market. In response to these needs key competencies in understanding, developing and using new digital technologies are being brought into focus in school and university programmes. The IFIP TC3 conference "KEYCIT – Key Competences in Informatics and ICT (KEYCIT 2014)" was held at the University of Potsdam in Germany from July 1st to 4th, 2014 and addressed the combination of key competencies, Informatics and ICT in detail. The conference was organized into strands focusing on secondary education, university education and teacher education (organized by IFIP WGs 3.1 and 3.3) and provided a forum to present and to discuss research, case studies, positions, and national perspectives in this field. T3 - Commentarii informaticae didacticae (CID) - 7 KW - Schlüsselkompetenzen KW - Informatik KW - Bildung KW - ICT KW - Informatikdidaktik KW - Key Competencies KW - Informatics KW - education KW - ICT KW - Computer Science Education Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-70325 SN - 978-3-86956-292-6 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Anderson, Christopher J. A1 - Bahnik, Stepan A1 - Barnett-Cowan, Michael A1 - Bosco, Frank A. A1 - Chandler, Jesse A1 - Chartier, Christopher R. A1 - Cheung, Felix A1 - Christopherson, Cody D. A1 - Cordes, Andreas A1 - Cremata, Edward J. A1 - Della Penna, Nicolas A1 - Estel, Vivien A1 - Fedor, Anna A1 - Fitneva, Stanka A. A1 - Frank, Michael C. A1 - Grange, James A. A1 - Hartshorne, Joshua K. A1 - Hasselman, Fred A1 - Henninger, Felix A1 - van der Hulst, Marije A1 - Jonas, Kai J. A1 - Lai, Calvin K. A1 - Levitan, Carmel A. A1 - Miller, Jeremy K. A1 - Moore, Katherine S. A1 - Meixner, Johannes M. A1 - Munafo, Marcus R. A1 - Neijenhuijs, Koen I. A1 - Nilsonne, Gustav A1 - Nosek, Brian A. A1 - Plessow, Franziska A1 - Prenoveau, Jason M. A1 - Ricker, Ashley A. A1 - Schmidt, Kathleen A1 - Spies, Jeffrey R. A1 - Stieger, Stefan A1 - Strohminger, Nina A1 - Sullivan, Gavin B. A1 - van Aert, Robbie C. M. A1 - van Assen, Marcel A. L. M. A1 - Vanpaemel, Wolf A1 - Vianello, Michelangelo A1 - Voracek, Martin A1 - Zuni, Kellylynn T1 - Response to Comment on "Estimating the reproducibility of psychological science" T2 - Science N2 - Gilbert et al. conclude that evidence from the Open Science Collaboration’s Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted. Y1 - 2016 U6 - https://doi.org/10.1126/science.aad9163 SN - 0036-8075 SN - 1095-9203 VL - 351 SP - 1162 EP - 1165 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - CHAP A1 - Borowski, Andreas A1 - Glowinski, Ingrid A1 - Frister, Jonas A1 - Höttecke, Dietmar A1 - Buth, Katrin A1 - Koenen, Jenna A1 - Masanek, Nicole A1 - Reichwein, Wilko A1 - Scholten, Nina A1 - Sprenger, Sandra A1 - Stender, Peter A1 - Wöhlke, Carina A1 - Komorek, Michael A1 - Freckmann, Janine A1 - Hofmann, Josefine A1 - Niesel, Verena A1 - Richter, Chris A1 - Mehlmann, Nelli A1 - Bikner-Ahsbahs, Angelika A1 - Unverricht, Katja A1 - Schanze, Sascha A1 - Bittorf, Robert Marten A1 - Meier, Monique A1 - Grospietsch, Finja A1 - Mayer, Jürgen A1 - Gimbel, Katharina A1 - Ziepprecht, Kathrin A1 - Hofmann, Judith A1 - Kramer, Charlotte A1 - Müller, Britta-Kornelia A1 - Rohde, Andreas A1 - Zühlsdorf, Felix A1 - Winkler, Iris A1 - Laging, Ralf A1 - Peter, Carina A1 - Schween, Michael A1 - Härle, Gerhard A1 - Busse, Beatrix A1 - Mahner, Sebastian A1 - Köstler, Verena A1 - Kufner, Sabrina A1 - Mägdefrau, Jutta A1 - Müller, Christian A1 - Beck, Christina A1 - Kriehuber, Eva A1 - Boch, Florian A1 - Engl, Anna-Teresa A1 - Helzel, Andreas A1 - Pickert, Tina A1 - Reiter, Christian A1 - Blasini, Bettina A1 - Nerdel, Claudia A1 - Lewalter, Doris A1 - Schiffhauer, Silke A1 - Richter-Gebert, Jürgen A1 - Bannert, Maria A1 - Maahs, Mirjam A1 - Reißner, Maria A1 - Ungar, Patrizia A1 - von Wachter, Jana-Kristin A1 - Hellmann, Katharina A1 - Zaki, Katja A1 - Pohlenz, Philipp ED - Glowinski, Ingrid ED - Borowski, Andreas ED - Gillen, Julia ED - Schanze, Sascha ED - von Meien, Joachim T1 - Kohärenz in der universitären Lehrerbildung T1 - Coherence in teacher education at university BT - Vernetzung von Fachwissenschaft, Fachdidaktik und Bildungswissenschaften BT - linking studies in content knowledge, pedagogical content knowledge and pedagogical knowledge in teacher education N2 - One area that is supported by the project “Qualitätsoffensive Lehrerbildung” (funded by BMBF) is the improvement of collaboration and coordination between studies in the discipline, studies in pedagogical content knowledge, and studies in pedagogical knowledge during teacher education at university. Aiming a better coordination among these three parts of teacher education at university, many of the supported projects have designed and realized university-specific approaches. This conference proceedings volume comprises contributions by 15 of these projects. Seven of those were introduced and discussed in workshops on the occasion of two cross-regional project-conferences in Hannover and Potsdam. Overall, the contributions give a theoretically funded as well as a practice-oriented overview of current approaches and concepts to achieve a better connection between study units concerning studies in content knowledge, pedagogical content knowledge and pedagogical knowledge in teacher education. The volume presents university projects, which take effect on different levels (at the level of curriculum and content, at a collegiate level, at the level of structural conditions of universities). The different approaches are described in a way that they can provide a basis for transfer to other subjects or further universities. The contributions are aimed at teacher educators as well as other actors working in the field of teaching- and quality development at universities. All of them can take transferable ideas and impulses from the described concepts and formats. N2 - Eine verbesserte Zusammenarbeit und Abstimmung von Fachwissenschaft, Fachdidaktik, Bildungswissenschaften und schulpraktischen Lernorten ist einer der Förderbereiche der „Qualitätsoffensive Lehrerbildung“. Zahlreiche der geförderten Projekte haben für dieses Handlungsfeld im Bereich Vernetzung von Fachwissenschaft, Fachdidaktik und Bildungswissenschaften hochschulspezifische Maßnahmen konzipiert und umgesetzt. Der vorliegende Tagungsband beinhaltet Beiträge von 15 entsprechenden Projekten, von denen sieben anlässlich von zwei standortübergreifenden Projekt-Tagungen in Hannover und Potsdam vorgestellt und in Workshops diskutiert wurden. Insgesamt geben die Beiträge einen theoretisch fundierten und gleichzeitig praxisorientierten Überblick über aktuelle Ansätze und Konzepte zur besseren Vernetzung fachwissenschaftlicher, fachdidaktischer und bildungswissenschaftlicher Studienanteile im Lehramtsstudium. Dargestellt werden Projektarbeiten der Hochschulen, die auf verschiedenen Ebenen wirksam werden (curricular-inhaltliche Ebene, kollegiale Ebene, hochschul-strukturelle Ebene). Die Maßnahmen sind so beschrieben, dass sie als Grundlage für einen Transfer auf andere Fächer bzw. andere Standorte genutzt werden können. Die Beiträge richten sich an alle Lehrenden im Bereich der Lehramtsbildung sowie sonstige Akteure im Bereich der Lehr- und Qualitätsentwicklung an den Universitäten. Sie alle können den beschriebenen Konzepten und Umsetzungsformaten transferierbare Ideen und Impulse entnehmen. KW - Professionswissen KW - universitäre Lehrerbildung KW - Vernetzung Fachwissenschaft KW - Fachdidaktik KW - Bildungswissenschaft KW - Lehramtsstudium KW - teacher education KW - professional knowledge KW - content knowledge KW - pedagogical content knowledge Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-414267 SN - 978-3-86956-438-8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Inal, Sahika A1 - Chiappisi, Leonardo A1 - Kölsch, Jonas D. A1 - Kraft, Mario A1 - Appavou, Marie-Sousai A1 - Scherf, Ullrich A1 - Wagner, Manfred A1 - Hansen, Michael Ryan A1 - Gradzielski, Michael A1 - Laschewsky, André A1 - Neher, Dieter T1 - Temperature-regulated fluorescence and association of an Oligo(ethyleneglycol)methacrylate-based copolymer with a conjugated Polyelectrolyte-the effect of solution ionic strength JF - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry N2 - Aqueous mixtures of a dye-labeled non-ionic thermoresponsive copolymer and a conjugated cationic polyelectrolyte are shown to exhibit characteristic changes in fluorescence properties in response to temperature and to the presence of salts, enabling a double-stimuli responsiveness. In such mixtures at room temperature, i.e., well below the lower critical solution temperature (LCST), the emission of the dye is strongly quenched due to energy transfer to the polycation, pointing to supramolecular interactions between the two macromolecules. Increasing the concentration of salts weakens the interpolymer interactions, the extent of which is simultaneously monitored from the change in the relative emission intensity of the components. When the mixture is heated above its LCST, the transfer efficiency is significantly reduced, signaling a structural reorganization process, however, surprisingly only if the mixture contains salt ions. To elucidate the reasons behind such thermo- and ion-sensitive fluorescence characteristics, we investigate the effect of salts of alkali chlorides, in particular of NaCl, on the association behavior of these macromolecules before and after the polymer phase transition by a combination of UV-vis, fluorescence, and H-1 NMR spectroscopy with light scattering and small-angle neutron scattering measurements. Y1 - 2013 U6 - https://doi.org/10.1021/jp408864s SN - 1520-6106 VL - 117 IS - 46 SP - 14576 EP - 14587 PB - American Chemical Society CY - Washington ER - TY - CHAP A1 - Rolf, Arno A1 - Berges, Marc A1 - Hubwieser, Peter A1 - Kehrer, Timo A1 - Kelter, Udo A1 - Romeike, Ralf A1 - Frenkel, Marcus A1 - Karsten, Weicker A1 - Reinhardt, Wolfgang A1 - Mascher, Michael A1 - Gül, Senol A1 - Magenheim, Johannes A1 - Raimer, Stephan A1 - Diethelm, Ira A1 - Dünnebier, Malte A1 - Gabor, Kiss A1 - Susanne, Boll A1 - Rolf, Meinhardt A1 - Gronewold, Sabine A1 - Krekeler, Larissa A1 - Jahnke, Isa A1 - Haertel, Tobias A1 - Mattick, Volker A1 - Lettow, Karsten A1 - Hafer, Jörg A1 - Ludwig, Joachim A1 - Schumann, Marlen A1 - Laroque, Christoph A1 - Schulte, Jonas A1 - Urban, Diana ED - Engbring, Dieter ED - Keil, Reinhard ED - Magenheim, Johannes ED - Selke, Harald T1 - HDI2010 – Tagungsband der 4. Fachtagung zur "Hochschuldidaktik Informatik" N2 - Mit der 4. Tagung zur Hochschuldidaktik Informatik wird eine Reihe fortgesetzt, die ihren Anfang 1998 in Stuttgart unter der Überschrift „Informatik und Ausbildung“ genommen hat. Seither dienen diese Tagungen den Lehrenden im Bereich der Hochschulinformatik als Forum der Information und des Diskurses über aktuelle didaktische und bildungspolitische Entwicklungen im Bereich der Informatikausbildung. Aktuell zählen dazu insbesondere Fragen der Bildungsrelevanz informatischer Inhalte und der Herausforderung durch eine stärkere Kompetenzorientierung in der Informatik. Die eingereichten Beiträge zur HDI 2010 in Paderborn veranschaulichen unterschiedliche Bemühungen, sich mit relevanten Problemen der Informatikdidaktik an Hochschulen in Deutschland (und z. T. auch im Ausland) auseinanderzusetzen. Aus der Breite des Spektrums der Einreichungen ergaben sich zugleich Probleme bei der Begutachtung. Letztlich konnten von den zahlreichen Einreichungen nur drei die Gutachter so überzeugen, dass sie uneingeschränkt in ihrer Langfassung akzeptiert wurden. Neun weitere Einreichungen waren trotz Kritik überwiegend positiv begutachtet worden, so dass wir diese als Kurzfassung bzw. Diskussionspapier in die Tagung aufgenommen haben. T3 - Commentarii informaticae didacticae (CID) - 4 Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-49167 SN - 978-3-86956-100-4 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Otto, Nils A1 - Marelja, Zvonimir A1 - Schoofs, Andreas A1 - Kranenburg, Holger A1 - Bittern, Jonas A1 - Yildirim, Kerem A1 - Berh, Dimitri A1 - Bethke, Maria A1 - Thomas, Silke A1 - Rode, Sandra A1 - Risse, Benjamin A1 - Jiang, Xiaoyi A1 - Pankratz, Michael A1 - Leimkühler, Silke A1 - Klämbt, Christian T1 - The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia JF - Nature Communications N2 - Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity. Y1 - 2018 U6 - https://doi.org/10.1038/s41467-018-05645-z SN - 2041-1723 VL - 9 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Sankaran, Mahesh A1 - Hanan, Niall P. A1 - Scholes, Robert J. A1 - Ratnam, Jayashree A1 - Cade, Brian S. A1 - Ardo, Jonas A1 - Augustine, David J. A1 - Banyikwa, Feetham A1 - Bronn, Andries A1 - Bucini, Gabriela A1 - Caylor, Kelly K. A1 - Coughenour, Michael B. A1 - Diouf, Alioune A1 - Feral, Christie J. A1 - February, Edmund C. A1 - Frost, Peter G. H. T1 - Determinants of woody cover in African savannas N2 - Savannas are globally important ecosystems of great significance to human economies. In these biomes, which are characterized by the co-dominance of trees and grasses, woody cover is a chief determinant of ecosystem properties(1-3). The availability of resources ( water, nutrients) and disturbance regimes ( fire, herbivory) are thought to be important in regulating woody cover(1,2,4,5), but perceptions differ on which of these are the primary drivers of savanna structure. Here we show, using data from 854 sites across Africa, that maximum woody cover in savannas receiving a mean annual precipitation (MAP) of less than similar to 650 mm is constrained by, and increases linearly with, MAP. These arid and semi-arid savannas may be considered 'stable' systems in which water constrains woody cover and permits grasses to coexist, while fire, herbivory and soil properties interact to reduce woody cover below the MAP- controlled upper bound. Above a MAP of similar to 650 mm, savannas are 'unstable' systems in which MAP is sufficient for woody canopy closure, and disturbances ( fire, herbivory) are required for the coexistence of trees and grass. These results provide insights into the nature of African savannas and suggest that future changes in precipitation(6) may considerably affect their distribution and dynamics Y1 - 2005 ER - TY - GEN A1 - Otto, Nils A1 - Marelja, Zvonimir A1 - Schoofs, Andreas A1 - Kranenburg, Holger A1 - Bittern, Jonas A1 - Yildirim, Kerem A1 - Berh, Dimitri A1 - Bethke, Maria A1 - Thomas, Silke A1 - Rode, Sandra A1 - Risse, Benjamin A1 - Jiang, Xiaoyi A1 - Pankratz, Michael A1 - Leimkühler, Silke A1 - Klämbt, Christian T1 - The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 975 KW - molybdenum cofactor deficiency KW - blood-brain-barrier KW - larval locomotion KW - energy-metabolism KW - cerebral-cortex KW - astrocytes KW - behavior KW - cells KW - transmission KW - disease KW - Diseases of the nervous system KW - Glial biology KW - Glial development KW - Neurotransmitters Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-426205 SN - 1866-8372 IS - 975 ER - TY - JOUR A1 - Connor, Daniel Oliver A1 - Zantow, Jonas A1 - Hust, Michael A1 - Bier, Frank Fabian A1 - von Nickisch-Rosenegk, Markus T1 - Identification of Novel Immunogenic Proteins of Neisseria gonorrhoeae by Phage Display JF - PLoS one N2 - Neisseria gonorrhoeae is one of the most prevalent sexually transmitted diseases worldwide with more than 100 million new infections per year. A lack of intense research over the last decades and increasing resistances to the recommended antibiotics call for a better understanding of gonococcal infection, fast diagnostics and therapeutic measures against N. gonorrhoeae. Therefore, the aim of this work was to identify novel immunogenic proteins as a first step to advance those unresolved problems. For the identification of immunogenic proteins, pHORF oligopeptide phage display libraries of the entire N. gonorrhoeae genome were constructed. Several immunogenic oligopeptides were identified using polyclonal rabbit antibodies against N. gonorrhoeae. Corresponding full-length proteins of the identified oligopeptides were expressed and their immunogenic character was verified by ELISA. The immunogenic character of six proteins was identified for the first time. Additional 13 proteins were verified as immunogenic proteins in N. gonorrhoeae. Y1 - 2016 U6 - https://doi.org/10.1371/journal.pone.0148986 SN - 1932-6203 VL - 11 PB - PLoS CY - San Fransisco ER - TY - GEN A1 - Connor, Daniel Oliver A1 - Zantow, Jonas A1 - Hust, Michael A1 - Bier, Frank Fabian A1 - von Nickisch-Rosenegk, Markus T1 - Identification of novel immunogenic proteins of Neisseria gonorrhoeae by phage display T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Neisseria gonorrhoeae is one of the most prevalent sexually transmitted diseases worldwide with more than 100 million new infections per year. A lack of intense research over the last decades and increasing resistances to the recommended antibiotics call for a better understanding of gonococcal infection, fast diagnostics and therapeutic measures against N. gonorrhoeae. Therefore, the aim of this work was to identify novel immunogenic proteins as a first step to advance those unresolved problems. For the identification of immunogenic proteins, pHORF oligopeptide phage display libraries of the entire N. gonorrhoeae genome were constructed. Several immunogenic oligopeptides were identified using polyclonal rabbit antibodies against N. gonorrhoeae. Corresponding full-length proteins of the identified oligopeptides were expressed and their immunogenic character was verified by ELISA. The immunogenic character of six proteins was identified for the first time. Additional 13 proteins were verified as immunogenic proteins in N. gonorrhoeae. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 541 KW - proteomic analysis KW - vaccine antigens KW - gene-expression KW - Mycobacterium tuberculosis KW - antimicrobial resistance KW - recombinant antibodies KW - Salmonella Thyphimurium KW - untreatable Gonorrhea KW - multidrug-resistant KW - Escherichia coli Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-411077 SN - 1866-8372 IS - 541 ER - TY - JOUR A1 - Beye, Martin A1 - Öberg, Henrik A1 - Xin, Hongliang A1 - Dakovski, Georgi L. A1 - Föhlisch, Alexander A1 - Gladh, Jorgen A1 - Hantschmann, Markus A1 - Hieke, Florian A1 - Kaya, Sarp A1 - Kühn, Danilo A1 - LaRue, Jerry A1 - Mercurio, Giuseppe A1 - Minitti, Michael P. A1 - Mitra, Ankush A1 - Moeller, Stefan P. A1 - Ng, May Ling A1 - Nilsson, Anders A1 - Nordlund, Dennis A1 - Norskov, Jens A1 - Öström, Henrik A1 - Ogasawara, Hirohito A1 - Persson, Mats A1 - Schlotter, William F. A1 - Sellberg, Jonas A. A1 - Wolf, Martin A1 - Abild-Pedersen, Frank A1 - Pettersson, Lars G. M. A1 - Wurth, Wilfried T1 - Chemical Bond Activation Observed with an X-ray Laser JF - The journal of physical chemistry letters N2 - The concept of bonding and antibonding orbitals is fundamental in chemistry. The population of those orbitals and the energetic difference between the two reflect the strength of the bonding interaction. Weakening the bond is expected to reduce this energetic splitting, but the transient character of bond-activation has so far prohibited direct experimental access. Here we apply time-resolved soft X-ray spectroscopy at a free electron laser to directly observe the decreased bonding antibonding splitting following bond-activation using an ultrashort optical laser pulse. Y1 - 2016 U6 - https://doi.org/10.1021/acs.jpclett.6b01543 SN - 1948-7185 VL - 7 SP - 3647 EP - 3651 PB - American Chemical Society CY - Washington ER - TY - THES A1 - Jonas, Michael T1 - Zur Verherrlichung preußischer Geschichte als Element der geistigen Kriegsvorbereitung 1933 - 1945 in Deutschland : organisationsspezifisch dargestellt am Erziehungssystem des Reichsarbeitsdienstes ; Anhang Y1 - 1992 CY - Potsdam ER - TY - THES A1 - Jonas, Michael T1 - Zur Verherrlichung preußischer Geschichte als Element der geistigen Kriegsvorbereitung 1933 - 1945 in Deutschland : organisationsspezifisch dargestellt am Erziehungssystem des Reichsarbeitsdienstes ; Hauptband Y1 - 1992 CY - Potsdam ER - TY - JOUR A1 - Xin, Hong A1 - LaRue, Jerry A1 - Oberg, Henrik A1 - Beye, Martin A1 - Turner, J. J. A1 - Gladh, Jörgen A1 - Ng, May L. A1 - Sellberg, Jonas A. A1 - Kaya, Sarp A1 - Mercurio, G. A1 - Hieke, F. A1 - Nordlund, Dennis A1 - Schlotter, William F. A1 - Dakovski, Georgi L. A1 - Minitti, Michael P. A1 - Föhlisch, Alexander A1 - Wolf, Martin A1 - Wurth, Wilfried A1 - Ogasawara, Hirohito A1 - Norskov, Jens K. A1 - Ostrom, Henrik A1 - Pettersson, Lars G. M. A1 - Nilsson, Anders A1 - Abild-Pedersen, Frank T1 - Strong Influence of Coadsorbate Interaction on CO Desorption Dynamics on Ru(0001) Probed by Ultrafast X-Ray Spectroscopy and Ab Initio Simulations JF - Physical review letters N2 - We show that coadsorbed oxygen atoms have a dramatic influence on the CO desorption dynamics from Ru(0001). In contrast to the precursor-mediated desorption mechanism on Ru(0001), the presence of surface oxygen modifies the electronic structure of Ru atoms such that CO desorption occurs predominantly via the direct pathway. This phenomenon is directly observed in an ultrafast pump-probe experiment using a soft x-ray free-electron laser to monitor the dynamic evolution of the valence electronic structure of the surface species. This is supported with the potential of mean force along the CO desorption path obtained from density-functional theory calculations. Charge density distribution and frozen-orbital analysis suggest that the oxygen-induced reduction of the Pauli repulsion, and consequent increase of the dative interaction between the CO 5 sigma and the charged Ru atom, is the electronic origin of the distinct desorption dynamics. Ab initio molecular dynamics simulations of CO desorption from Ru(0001) and oxygen-coadsorbed Ru(0001) provide further insights into the surface bond-breaking process. Y1 - 2015 U6 - https://doi.org/10.1103/PhysRevLett.114.156101 SN - 0031-9007 SN - 1079-7114 VL - 114 IS - 15 PB - American Physical Society CY - College Park ER - TY - GEN A1 - Schwerbel, Kristin A1 - Kamitz, Anne A1 - Jaehnert, Markus A1 - Gottmann, P. A1 - Schumacher, Fabian A1 - Kleuser, Burkhard A1 - Haltenhof, T. A1 - Heyd, F. A1 - Roden, Michael A1 - Chadt, Alexandra A1 - Al-Hasani, Hadi A1 - Jonas, W. A1 - Vogel, Heike A1 - Schürmann, Annette T1 - Two immune-related GTPases prevent from hepatic fat accumulation by inducing autophagy T2 - Diabetologia : journal of the European Association for the Study of Diabetes (EASD) Y1 - 2018 SN - 0012-186X SN - 1432-0428 VL - 61 SP - S259 EP - S259 PB - Springer CY - New York ER - TY - JOUR A1 - Sellberg, Jonas A. A1 - McQueen, Trevor A. A1 - Laksmono, Hartawan A1 - Schreck, Simon A1 - Beye, Martin A1 - DePonte, Daniel P. A1 - Kennedy, Brian A1 - Nordlund, Dennis A1 - Sierra, Raymond G. A1 - Schlesinger, Daniel A1 - Tokushima, Takashi A1 - Zhovtobriukh, Iurii A1 - Eckert, Sebastian A1 - Segtnan, Vegard H. A1 - Ogasawara, Hirohito A1 - Kubicek, Katharina A1 - Techert, Simone A1 - Bergmann, Uwe A1 - Dakovski, Georgi L. A1 - Schlotter, William F. A1 - Harada, Yoshihisa A1 - Bogan, Michael J. A1 - Wernet, Philippe A1 - Föhlisch, Alexander A1 - Pettersson, Lars G. M. A1 - Nilsson, Anders T1 - X-ray emission spectroscopy of bulk liquid water in "no-man's land" JF - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr N2 - The structure of bulk liquid water was recently probed by x-ray scattering below the temperature limit of homogeneous nucleation (T-H) of similar to 232 K [J. A. Sellberg et al., Nature 510, 381-384 (2014)]. Here, we utilize a similar approach to study the structure of bulk liquid water below T-H using oxygen K-edge x-ray emission spectroscopy (XES). Based on previous XES experiments [T. Tokushima et al., Chem. Phys. Lett. 460, 387-400 (2008)] at higher temperatures, we expected the ratio of the 1b(1)' and 1b(1)" peaks associated with the lone-pair orbital in water to change strongly upon deep supercooling as the coordination of the hydrogen (H-) bonds becomes tetrahedral. In contrast, we observed only minor changes in the lone-pair spectral region, challenging an interpretation in terms of two interconverting species. A number of alternative hypotheses to explain the results are put forward and discussed. Although the spectra can be explained by various contributions from these hypotheses, we here emphasize the interpretation that the line shape of each component changes dramatically when approaching lower temperatures, where, in particular, the peak assigned to the proposed disordered component would become more symmetrical as vibrational interference becomes more important. (C) 2015 AIP Publishing LLC. Y1 - 2015 U6 - https://doi.org/10.1063/1.4905603 SN - 0021-9606 SN - 1089-7690 VL - 142 IS - 4 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Schreck, Simon A1 - Beye, Martin A1 - Sellberg, Jonas A. A1 - McQueen, Trevor A1 - Laksmono, Hartawan A1 - Kennedy, Brian A1 - Eckert, Sebastian A1 - Schlesinger, Daniel A1 - Nordlund, Dennis A1 - Ogasawara, Hirohito A1 - Sierra, Raymond G. A1 - Segtnan, Vegard H. A1 - Kubicek, Katharina A1 - Schlotter, William F. A1 - Dakovski, Georgi L. A1 - Moeller, Stefan P. A1 - Bergmann, Uwe A1 - Techert, Simone A1 - Pettersson, Lars G. M. A1 - Wernet, Philippe A1 - Bogan, Michael J. A1 - Harada, Yoshihisa A1 - Nilsson, Anders A1 - Föhlisch, Alexander T1 - Reabsorption of soft x-ray emission at high x-ray free-electron laserfluences JF - Physical review letters N2 - We report on oxygen K-edge soft x-ray emission spectroscopy from a liquid water jet at the Linac Coherent Light Source. We observe significant changes in the spectral content when tuning over a wide range of incident x-ray fluences. In addition the total emission yield decreases at high fluences. These modifications result from reabsorption of x-ray emission by valence-excited molecules generated by the Auger cascade. Our observations have major implications for future x-ray emission studies at intense x-ray sources. We highlight the importance of the x-ray pulse length with respect to the core-hole lifetime. Y1 - 2014 U6 - https://doi.org/10.1103/PhysRevLett.113.153002 SN - 0031-9007 SN - 1079-7114 VL - 113 IS - 15 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Kokhanovsky, Alexander A1 - Lamare, Maxim A1 - Danne, Olaf A1 - Brockmann, Carsten A1 - Dumont, Marie A1 - Picard, Ghislain A1 - Arnaud, Laurent A1 - Favier, Vincent A1 - Jourdain, Bruno A1 - Le Meur, Emmanuel A1 - Di Mauro, Biagio A1 - Aoki, Teruo A1 - Niwano, Masashi A1 - Rozanov, Vladimir A1 - Korkin, Sergey A1 - Kipfstuhl, Sepp A1 - Freitag, Johannes A1 - Hoerhold, Maria A1 - Zuhr, Alexandra A1 - Vladimirova, Diana A1 - Faber, Anne-Katrine A1 - Steen-Larsen, Hans Christian A1 - Wahl, Sonja A1 - Andersen, Jonas K. A1 - Vandecrux, Baptiste A1 - van As, Dirk A1 - Mankoff, Kenneth D. A1 - Kern, Michael A1 - Zege, Eleonora A1 - Box, Jason E. T1 - Retrieval of Snow Properties from the Sentinel-3 Ocean and Land Colour Instrument JF - Remote sensing N2 - The Sentinel Application Platform (SNAP) architecture facilitates Earth Observation data processing. In this work, we present results from a new Snow Processor for SNAP. We also describe physical principles behind the developed snow property retrieval technique based on the analysis of Ocean and Land Colour Instrument (OLCI) onboard Sentinel-3A/B measurements over clean and polluted snow fields. Using OLCI spectral reflectance measurements in the range 400-1020 nm, we derived important snow properties such as spectral and broadband albedo, snow specific surface area, snow extent and grain size on a spatial grid of 300 m. The algorithm also incorporated cloud screening and atmospheric correction procedures over snow surfaces. We present validation results using ground measurements from Antarctica, the Greenland ice sheet and the French Alps. We find the spectral albedo retrieved with accuracy of better than 3% on average, making our retrievals sufficient for a variety of applications. Broadband albedo is retrieved with the average accuracy of about 5% over snow. Therefore, the uncertainties of satellite retrievals are close to experimental errors of ground measurements. The retrieved surface grain size shows good agreement with ground observations. Snow specific surface area observations are also consistent with our OLCI retrievals. We present snow albedo and grain size mapping over the inland ice sheet of Greenland for areas including dry snow, melted/melting snow and impurity rich bare ice. The algorithm can be applied to OLCI Sentinel-3 measurements providing an opportunity for creation of long-term snow property records essential for climate monitoring and data assimilation studies-especially in the Arctic region, where we face rapid environmental changes including reduction of snow/ice extent and, therefore, planetary albedo. KW - snow characteristics KW - optical remote sensing KW - snow grain size KW - specific surface area KW - albedo KW - Sentinel 3 KW - OLCI Y1 - 2019 U6 - https://doi.org/10.3390/rs11192280 SN - 2072-4292 VL - 11 IS - 19 PB - MDPI CY - Basel ER - TY - JOUR A1 - Thulin, Mirjam A1 - Krah, Markus A1 - Meyer, Michael A. A1 - Schorsch, Ismar A1 - Brodt, Eliezer A1 - Sariel, Eliezer A1 - Yedidya, Asaf A1 - Esther, Solomon A1 - Kessler, Samuel J. A1 - Bratkin, Dimitri A1 - Sax, Benjamin E. A1 - Stair, Rose A1 - Ariel, Yaakov S. A1 - Weidner, Daniel A1 - Ebert, Sophia A1 - Martini, Annett A1 - Fischer, Bernd A1 - Thüne, Eva-Maria A1 - Bock, Dennis A1 - Engelmann, Jonas A1 - Aust, Cornelia A1 - Walter, Nancy ED - Krah, Markus ED - Thulin, Mirjam ED - Pick, Bianca T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Cultures of Wissenschaft des Judentums at 200 T2 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e. V. N2 - PaRDeS, the journal of the German Association for Jewish Studies, aims at exploring the fruitful and multifarious cultures of Judaism as well as their relations to their environment within diverse areas of research. In addition, the journal promotes Jewish Studies within academic discourse and reflects on its historic and social responsibilities. N2 - PaRDeS, die Zeitschrift der Vereinigung für Jüdische Studien e. V., erforscht die fruchtbare kulturelle Vielfalt des Judentums sowie ihre Berührungspunkte zur nichtjüdischen Umwelt in unterschiedlichen Bereichen. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung. T3 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 24 Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-414943 SN - 978-3-86956-440-1 SN - 1614-6492 SN - 1862-7684 IS - 24 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Jonas, Kristina A1 - Jaecks, Petra A1 - Niebuhr-Siebert, Sandra A1 - Wahl, Michael A1 - Leinweber, Juliane A1 - Bilda, Kerstin A1 - Plößel, Laura A1 - Heide, Judith A1 - Netzebandt, Jonka A1 - Brüsch, Julia A1 - Diener, Antonia A1 - Hubert, Cilly A1 - Menze, Clara A1 - Neitzel, Isabel A1 - Tenhagen, Anne A1 - Kauschke, Christina A1 - Siegmüller, Julia A1 - Sachse, Steffi A1 - Dörfler, Tobias A1 - Machleb, Franziska A1 - Seyboth, Margret A1 - Eikerling, Maren A1 - Vona, Francesco A1 - Garzotto, Franca A1 - Lorusso, Maria Luisa ED - Fritzsche, Tom ED - Breitenstein, Sarah ED - Wunderlich, Hanna ED - Ferchland, Lisa T1 - Spektrum Patholinguistik Band 14. Schwerpunktthema: Klick für Klick: Schritte in der digitalen Sprachtherapie N2 - Das 14. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Klick für Klick: Schritte in der digitalen Sprachtherapie« fand am 14.11.2020 als Online-Veranstaltung statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) in Kooperation mit dem Deutschen Bundesverband für akademische Sprachtherapie und Logopädie (dbs) und der Universität Potsdam durchgeführt. Der vorliegende Tagungsband beinhaltet die Hauptvorträge zum Schwerpunktthema sowie die Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Fourteenth Autumn Meeting Patholinguistics with its main topic »Click by click: Steps towards a digital speech/language therapy« took place online on the 14th of November 2020. This annual meeting has been organised since 2007 by the Association for Patholinguistics (vpl) in cooperation with the German Federal Association for Academic Speech/Language Therapy and Logopaedics (dbs) and the University of Potsdam. The present proceedings feature the keynote presentations on the main topic as well as articles from the poster session covering a broad range of areas in research and practice of speech/language therapy. T3 - Spektrum Patholinguistik - 14 KW - Patholinguistik KW - Sprachtherapie KW - Teletherapie KW - digitale Medien und Apps KW - Digitalisierung KW - patholinguistics KW - speech/language therapy KW - teletherapy KW - digital media and apps KW - digitalisation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-500160 SN - 978-3-86956-507-1 SN - 1866-9433 SN - 1869-3822 IS - 14 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Inal, Sahika A1 - Koelsch, Jonas D. A1 - Chiappisi, Leonardo A1 - Kraft, Mario A1 - Gutacker, Andrea A1 - Janietz, Dietmar A1 - Scherf, Ullrich A1 - Gradzielski, Michael A1 - Laschewsky, André A1 - Neher, Dieter T1 - Temperature-Regulated Fluorescence Characteristics of Supramolecular Assemblies Formed By a Smart Polymer and a Conjugated Polyelectrolyte JF - MACROMOLECULAR CHEMISTRY AND PHYSICS N2 - Aqueous mixtures of a coumarin-labeled non-ionic thermoresponsive copolymer and a cationic polythiophene exhibit marked changes in their fluorescence properties upon heating. At room temperature, emission from the label is significantly quenched due to energy transfer to the conjugated polyelectrolyte. Heating the mixture reduces the energy-transfer efficiency markedly, resulting in a clearly visible change of the emission color. Although the two macromolecules associate strongly at room temperature, the number of interacting sites is largely reduced upon the phase transition. Crucially, the intermolecular association does not suppress the responsiveness of the smart polymer, meaning that this concept should be applicable to chemo- or bioresponsive polymers with optical read-out, for example, as a sensor device. KW - aqueous solutions KW - conjugated polyelectrolytes KW - fluorescence (or Forster) KW - resonance energy transfer KW - phase transitions KW - thermoresponsive polymers Y1 - 2013 U6 - https://doi.org/10.1002/macp.201200493 SN - 1022-1352 VL - 214 IS - 4 SP - 435 EP - 445 PB - WILEY-V C H VERLAG GMBH CY - WEINHEIM ER - TY - JOUR A1 - Inal, Sahika A1 - Kölsch, Jonas D. A1 - Chiappisi, Leonardo A1 - Janietz, Dietmar A1 - Gradzielski, Michael A1 - Laschewsky, André A1 - Neher, Dieter T1 - Structure-related differences in the temperature-regulated fluorescence response of LCST type polymers N2 - We demonstrate new fluorophore-labelled materials based on acrylamide and on oligo(ethylene glycol) (OEG) bearing thermoresponsive polymers for sensing purposes and investigate their thermally induced solubility transitions. It is found that the emission properties of the polarity-sensitive (solvatochromic) naphthalimide derivative attached to three different thermoresponsive polymers are highly specific to the exact chemical structure of the macromolecule. While the dye emits very weakly below the LCST when incorporated into poly(N-isopropylacrylamide) (pNIPAm) or into a polyacrylate backbone bearing only short OEG side chains, it is strongly emissive in polymethacrylates with longer OEG side chains. Heating of the aqueous solutions above their cloud point provokes an abrupt increase of the fluorescence intensity of the labelled pNIPAm, whereas the emission properties of the dye are rather unaffected as OEG-based polyacrylates and methacrylates undergo phase transition. Correlated with laser light scattering studies, these findings are ascribed to the different degrees of pre-aggregation of the chains at low temperatures and to the extent of dehydration that the phase transition evokes. It is concluded that although the temperature-triggered changes in the macroscopic absorption characteristics, related to large-scale alterations of the polymer chain conformation and aggregation, are well detectable and similar for these LCST-type polymers, the micro-environment provided to the dye within each polymer network differs substantially. Considering sensing applications, this finding is of great importance since the temperature-regulated fluorescence response of the polymer depends more on the macromolecular architecture than the type of reporter fluorophore. Y1 - 2013 UR - http://pubs.rsc.org/en/content/articlepdf/2013/tc/c3tc31304b U6 - https://doi.org/10.1039/C3TC31304B ER - TY - JOUR A1 - Inal, Sahika A1 - Koelsch, Jonas D. A1 - Chiappisi, Leonardo A1 - Janietz, Dietmar A1 - Gradzielski, Michael A1 - Laschewsky, André A1 - Neher, Dieter T1 - Structure-related differences in the temperature-regulated fluorescence response of LCST type polymers JF - Journal of materials chemistry : C, Materials for optical and electronic devices N2 - We demonstrate new fluorophore-labelled materials based on acrylamide and on oligo(ethylene glycol) (OEG) bearing thermoresponsive polymers for sensing purposes and investigate their thermally induced solubility transitions. It is found that the emission properties of the polarity-sensitive (solvatochromic) naphthalimide derivative attached to three different thermoresponsive polymers are highly specific to the exact chemical structure of the macromolecule. While the dye emits very weakly below the LCST when incorporated into poly(N-isopropylacrylamide) (pNIPAm) or into a polyacrylate backbone bearing only short OEG side chains, it is strongly emissive in polymethacrylates with longer OEG side chains. Heating of the aqueous solutions above their cloud point provokes an abrupt increase of the fluorescence intensity of the labelled pNIPAm, whereas the emission properties of the dye are rather unaffected as OEG-based polyacrylates and methacrylates undergo phase transition. Correlated with laser light scattering studies, these findings are ascribed to the different degrees of pre-aggregation of the chains at low temperatures and to the extent of dehydration that the phase transition evokes. It is concluded that although the temperature-triggered changes in the macroscopic absorption characteristics, related to large-scale alterations of the polymer chain conformation and aggregation, are well detectable and similar for these LCST-type polymers, the micro-environment provided to the dye within each polymer network differs substantially. Considering sensing applications, this finding is of great importance since the temperature-regulated fluorescence response of the polymer depends more on the macromolecular architecture than the type of reporter fluorophore. Y1 - 2013 U6 - https://doi.org/10.1039/c3tc31304b SN - 2050-7526 VL - 1 IS - 40 SP - 6603 EP - 6612 PB - Royal Society of Chemistry CY - Cambridge ER - TY - GEN A1 - Inal, Sahika A1 - Kölsch, Jonas D. A1 - Chiappisi, Leonardo A1 - Janietz, Dietmar A1 - Gradzielski, Michael A1 - Laschewsky, André A1 - Neher, Dieter T1 - Structure-related differences in the temperature-regulated fluorescence response of LCST type polymers N2 - We demonstrate new fluorophore-labelled materials based on acrylamide and on oligo(ethylene glycol) (OEG) bearing thermoresponsive polymers for sensing purposes and investigate their thermally induced solubility transitions. It is found that the emission properties of the polarity-sensitive (solvatochromic) naphthalimide derivative attached to three different thermoresponsive polymers are highly specific to the exact chemical structure of the macromolecule. While the dye emits very weakly below the LCST when incorporated into poly(N-isopropylacrylamide) (pNIPAm) or into a polyacrylate backbone bearing only short OEG side chains, it is strongly emissive in polymethacrylates with longer OEG side chains. Heating of the aqueous solutions above their cloud point provokes an abrupt increase of the fluorescence intensity of the labelled pNIPAm, whereas the emission properties of the dye are rather unaffected as OEG-based polyacrylates and methacrylates undergo phase transition. Correlated with laser light scattering studies, these findings are ascribed to the different degrees of pre-aggregation of the chains at low temperatures and to the extent of dehydration that the phase transition evokes. It is concluded that although the temperature-triggered changes in the macroscopic absorption characteristics, related to large-scale alterations of the polymer chain conformation and aggregation, are well detectable and similar for these LCST-type polymers, the micro-environment provided to the dye within each polymer network differs substantially. Considering sensing applications, this finding is of great importance since the temperature-regulated fluorescence response of the polymer depends more on the macromolecular architecture than the type of reporter fluorophore. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 251 KW - anionic polymerizations KW - dilute aqueous-solutions KW - ether methacrylates KW - n-isopropylacrylamide KW - oligo(ethylene glycol) methacrylate KW - phase-transitions KW - protein interactions KW - solvatochromic fluorophore KW - thermoresponsive polymers KW - to-coil transition Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95379 SP - 6603 EP - 6612 ER -