TY  - JOUR
A1  - Menzel, Juliane
A1  - Longree, Alessa
A1  - Abraham, Klaus
A1  - Schulze, Matthias Bernd
A1  - Weikert, Cornelia
T1  - Dietary and plasma phospholipid profiles in vegans and omnivores-results from the RBVD study
JF  - Nutrients
N2  - Over the last few years, the vegan diet has become increasingly popular in Germany. It has been proposed that this diet is generally lower in fat, but less is known about the impact on fatty acid (FA) profiles. Therefore, the cross-sectional "Risks and Benefits of a Vegan Diet" (RBVD) study (n = 72) was used to investigate dietary FA intake as well as plasma phospholipid FA in vegans (n = 36) compared to omnivores (n = 36). Vegans had a significantly lower dietary intake of total fat (median 86 g/day, IQR 64-111) in comparison to omnivores (median 104 g/day, IQR 88-143, p = 0.004). Further, vegans had a lower intake of saturated fatty acids (SFA) (p < 0.0001) and monounsaturated fatty acids (MUFA) (p = 0.001) compared to omnivores. Vegans had a higher intake in total polyunsaturated fatty acids (PUFA), omega-3 and omega-6 PUFA compared to omnivores, but without statistical significance after Bonferroni correction. According to plasma phospholipid profiles, relatively lower proportions of SFA (p < 0.0001), total trans fatty acids (TFA) (p = 0.0004) and omega-3-FA (p < 0.0001), but higher proportions of omega-6-FA (p < 0.0001) were observed in vegans. With the exception of omega-3 PUFA, a vegan diet is associated with a more favorable dietary fat intake and more favorable plasma FA profiles and therefore may reduce cardiovascular risk.
KW  - SFA
KW  - TFA
KW  - MUFA
KW  - PUFA
KW  - n-3 fatty acid
KW  - n-6 fatty acid
KW  - fatty acids
KW  - vegan diet
Y1  - 2022
U6  - https://doi.org/10.3390/nu14142900
SN  - 2072-6643
VL  - 14
IS  - 14
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Eichelmann, Fabian
A1  - Schulze, Matthias Bernd
A1  - Wittenbecher, Clemens
A1  - Menzel, Juliane
A1  - Weikert, Cornelia
A1  - di Giuseppe, Romina
A1  - Biemann, Ronald
A1  - Isermann, Berend
A1  - Fritsche, Andreas
A1  - Boeing, Heiner
A1  - Aleksandrova, Krasimira
T1  - Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer
JF  - JAMA network open
N2  - IMPORTANCE Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. OBJECTIVE To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. DESIGN, SETTING, AND PARTICIPANTS Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. MAIN OUTCOMES AND MEASURES Incident CRC, colon cancer, and rectal cancer. Baseline chemerin plasma concentrations were measured by enzyme-linked immunosorbent assay. CONCLUSIONS AND RELEVANCE This study found that the association between chemerin concentration and the risk of incident CRC was linear and independent of established CRC risk factors. Further studies are warranted to evaluate chemerin as a novel immune-inflammatory agent in colorectal carcinogenesis.
Y1  - 2019
U6  - https://doi.org/10.1001/jamanetworkopen.2019.0896
SN  - 2574-3805
VL  - 2
IS  - 3
PB  - American Veterinary Medical Association
CY  - Chicago
ER  -