TY  - JOUR
A1  - Li, Jian
A1  - Lu, Yong-Ping
A1  - Tsuprykov, Oleg
A1  - Hasan, Ahmed Abdallah Abdalrahman Mohamed
A1  - Reichetzeder, Christoph
A1  - Tian, Mei
A1  - Zhang, Xiao Li
A1  - Zhang, Qin
A1  - Sun, Guo-Ying
A1  - Guo, Jingli
A1  - Gaballa, Mohamed Mahmoud Salem Ahmed
A1  - Peng, Xiao-Ning
A1  - Lin, Ge
A1  - Hocher, Berthold
T1  - Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet
JF  - Diabetologia : journal of the European Association for the Study of Diabetes (EASD)
N2  - Aims/hypothesis Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy. Methods Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams. After mating, the F0 dams were fed control diet with or without folate during pregnancy.
KW  - Glucose tolerance
KW  - High-fat-sucrose-salt diet
KW  - Maternal folate treatment
KW  - Paternal programming
Y1  - 2018
U6  - https://doi.org/10.1007/s00125-018-4635-x
SN  - 0012-186X
SN  - 1432-0428
VL  - 61
IS  - 8
SP  - 1862
EP  - 1876
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Tian, Mei
A1  - Reichetzeder, Christoph
A1  - Li, Jian
A1  - Hocher, Berthold
T1  - Low birth weight, a risk factor for diseases in later life, is a surrogate of insulin resistance at birth
JF  - Journal of hypertension
N2  - Low birth weight (LBW) is associated with diseases in adulthood. The birthweight attributed risk is independent of confounding such as gestational age, sex of the newborn but also social factors. The birthweight attributed risk for diseases in later life holds for the whole spectrum of birthweight. This raises the question what pathophysiological principle is actually behind the association. In this review, we provide evidence that LBW is a surrogate of insulin resistance. Insulin resistance has been identified as a key factor leading to type 2 diabetes, cardiovascular disease as well as kidney diseases. We first provide evidence linking LBW to insulin resistance during intrauterine life. This might be caused by both genetic (genetic variations of genes controlling glucose homeostasis) and/or environmental factors (due to alterations of macronutrition and micronutrition of the mother during pregnancy, but also effects of paternal nutrition prior to conception) leading via epigenetic modifications to early life insulin resistance and alterations of intrauterine growth, as insulin is a growth factor in early life. LBW is rather a surrogate of insulin resistance in early life - either due to inborn genetic or environmental reasons - rather than a player on its own.
KW  - epigenetics
KW  - fetal programing
KW  - genetics
KW  - insulin resistance
KW  - low birth weight
Y1  - 2019
U6  - https://doi.org/10.1097/HJH.0000000000002156
SN  - 0263-6352
SN  - 1473-5598
VL  - 37
IS  - 11
SP  - 2123
EP  - 2134
PB  - Kluwer
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Zhu, Zhennan
A1  - Tian, Hong
A1  - Kempka, Thomas
A1  - Jiang, Guosheng
A1  - Dou, Bin
A1  - Mei, Gang
T1  - Mechanical behaviors of granite after thermal treatment under loading and unloading conditions
JF  - Natural resources research / sponsored by the International Association for Mathematical Geology
N2  - Understanding the mechanical behaviors of granite after thermal treatment under loading and unloading conditions is of utmost relevance to deep geothermal energy recovery. In the present study, a series of loading and unloading triaxial compression tests (20, 40 and 60 MPa) on granite specimens after exposure to different temperatures (20, 200, 300, 400, 500 and 600 degrees C) was carried out to quantify the combined effects of thermal treatment and loading/unloading stress conditions on granite strength and deformation. Changes in the microstructure of granite exposed to high temperatures were revealed by optical microscopy. The experimental results indicate that both, thermal treatment and loading/unloading stress conditions, degrade the mechanical behaviors and further decrease the carrying capacity of granite. The gradual degradation of the mechanical characteristics of granite after thermal treatment is mainly associated with the evolution of thermal micro-cracks based on optical microscopy observations. The unloading stress state induces the extension of tension cracks parallel to the axial direction, and thus, the mechanical properties are degraded. Temperatures above 400 degrees C have a more significant influence on the mechanical characteristics of granite than the unloading treatment, whereby 400 degrees C can be treated as a threshold temperature for the delineation of significant deterioration. This study is expected to support feasibility and risk assessments by means of providing data for analytical calculations and numerical simulations on granite exposed to high temperatures during geothermal energy extraction.
KW  - Granite
KW  - Thermal treatment
KW  - Unloading
KW  - Mechanical properties
KW  - Micro-structure
Y1  - 2021
U6  - https://doi.org/10.1007/s11053-021-09815-7
SN  - 1520-7439
SN  - 1573-8981
VL  - 30
IS  - 3
SP  - 2733
EP  - 2752
PB  - Springer Science + Business Media B.V.
CY  - New York, NY [u.a.]
ER  - 
TY  - JOUR
A1  - Li, Jian
A1  - Shen, Jinhua
A1  - Zhang, Xiaoli
A1  - Peng, Yangqin
A1  - Zhang, Qin
A1  - Hu, Liang
A1  - Reichetzeder, Christoph
A1  - Zeng, Suimin
A1  - Li, Jing
A1  - Tian, Mei
A1  - Gong, Fei
A1  - Lin, Ge
A1  - Hocher, Berthold
T1  - Risk factors associated with preterm birth after IVF/ICSI
JF  - Scientific reports
N2  - In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is associated with an increased risk of preterm (33rd-37th gestational week) and early preterm birth (20th-32nd gestational week). The underlying general and procedure related risk factors are not well understood so far. 4328 infertile women undergoing IVF/ICSI were entered into this study. The study population was divided into three groups: (a) early preterm birth group (n = 66), (b) preterm birth group (n = 675) and (c) full-term birth group (n = 3653). Odds for preterm birth were calculated by stepwise multivariate logistic regression analysis. We identified seven independent risk factors for preterm birth and four independent risk factors for early preterm birth. Older (> 39) or younger (< 25) maternal age (OR: 1.504, 95% CI 1.108-2.042, P = 0.009; OR: 2.125, 95% CI 1.049-4.304, P = 0.036, respectively), multiple pregnancy (OR: 9.780, 95% CI 8.014-11.935, P < 0.001; OR: 8.588, 95% CI 4.866-15.157, P < 0.001, respectively), placenta previa (OR: 14.954, 95% CI 8.053-27.767, P < 0.001; OR: 16.479, 95% CI 4.381-61.976, P < 0.001, respectively), and embryo reduction (OR: 3.547, 95% CI 1.736-7.249, P = 0.001; OR: 7.145, 95% CI 1.990-25.663, P = 0.003, respectively) were associated with preterm birth and early preterm birth, whereas gestational hypertension (OR: 2.494, 95% CI 1.770-3.514, P < 0.001), elevated triglycerides (OR: 1.120, 95% CI 1.011-1.240, P = 0.030) and shorter activated partial thromboplastin time (OR: 0.967, 95% CI 0.949-0.985, P < 0.001) were associated only with preterm birth. In conclusion, preterm and early preterm birth risk factors in patients undergoing assisted IVF/ICSI are in general similar to those in natural pregnancy. The lack of some associations in the early preterm group was most likely due to the lower number of early preterm birth cases. Only embryo reduction represents an IVF/ICSI specific risk factor.
Y1  - 2022
U6  - https://doi.org/10.1038/s41598-022-12149-w
SN  - 2045-2322
VL  - 12
IS  - 1
PB  - Nature Research
CY  - Berlin
ER  -