TY - GEN A1 - Malchow, Martin A1 - Renz, Jan A1 - Bauer, Matthias A1 - Meinel, Christoph T1 - Embedded smart home BT - remote lab grading in a MOOC with over 6000 participants T2 - 11th Annual IEEE International Systems Conference (SysCon) N2 - The popularity of MOOCs has increased considerably in the last years. A typical MOOC course consists of video content, self tests after a video and homework, which is normally in multiple choice format. After solving this homeworks for every week of a MOOC, the final exam certificate can be issued when the student has reached a sufficient score. There are also some attempts to include practical tasks, such as programming, in MOOCs for grading. Nevertheless, until now there is no known possibility to teach embedded system programming in a MOOC course where the programming can be done in a remote lab and where grading of the tasks is additionally possible. This embedded programming includes communication over GPIO pins to control LEDs and measure sensor values. We started a MOOC course called "Embedded Smart Home" as a pilot to prove the concept to teach real hardware programming in a MOOC environment under real life MOOC conditions with over 6000 students. Furthermore, also students with real hardware have the possibility to program on their own real hardware and grade their results in the MOOC course. Finally, we evaluate our approach and analyze the student acceptance of this approach to offer a course on embedded programming. We also analyze the hardware usage and working time of students solving tasks to find out if real hardware programming is an advantage and motivating achievement to support students learning success. Y1 - 2017 SN - 978-1-5090-4623-2 U6 - https://doi.org/10.1109/SYSCON.2017.7934728 SN - 1944-7620 SP - 195 EP - 200 PB - IEEE CY - New York ER - TY - JOUR A1 - Hoffmann, Holger A1 - Ott, Christiane A1 - Raupbach, Jana A1 - Andernach, Lars A1 - Renz, Matthias A1 - Grune, Tilman A1 - Hanschen, Franziska S. T1 - Assessing bioavailability and bioactivity of 4-Hydroxythiazolidine-2-Thiones, newly discovered glucosinolate degradation products formed during domestic boiling of cabbage JF - Frontiers in nutrition N2 - Glucosinolates are plant secondary metabolites found in cruciferous vegetables (Brassicaceae) that are valued for their potential health benefits. Frequently consumed representatives of these vegetables, for example, are white or red cabbage, which are typically boiled before consumption. Recently, 3-alk(en)yl-4-hydroxythiazolidine-2-thiones were identified as a class of thermal glucosinolate degradation products that are formed during the boiling of cabbage. Since these newly discovered compounds are frequently consumed, this raises questions about their potential uptake and their possible bioactive functions. Therefore, 3-allyl-4-hydroxythiazolidine-2-thione (allyl HTT) and 4-hydroxy-3-(4-(methylsulfinyl) butyl)thiazolidine-2-thione (4-MSOB HTT) as degradation products of the respective glucosinolates sinigrin and glucoraphanin were investigated. After consumption of boiled red cabbage broth, recoveries of consumed amounts of the degradation products in urine collected for 24 h were 18 +/- 5% for allyl HTT and 21 +/- 4% for 4-MSOB HTT (mean +/- SD, n = 3). To investigate the stability of the degradation products during uptake and to elucidate the uptake mechanism, both an in vitro stomach and an in vitro intestinal model were applied. The results indicate that the uptake of allyl HTT and 4-MSOB HTT occurs by passive diffusion. Both compounds show no acute cell toxicity, no antioxidant potential, and no change in NAD(P)H dehydrogenase quinone 1 (NQO1) activity up to 100 mu M. However, inhibition of glycogen synthase kinases-3 (GSK-3) in the range of 20% for allyl HTT for the isoform GSK-3 beta and 29% for 4-MSOB HTT for the isoform GSK-3 alpha at a concentration of 100 mu M was found. Neither health-promoting nor toxic effects of 3-alk(en)yl-4-hydroxythiazolidine-2-thiones were found in the four tested assays carried out in this study, which contrasts with the properties of other glucosinolate degradation products, such as isothiocyanates. KW - stomach model KW - glycogen synthase kinase-3 KW - cytotoxicity KW - antioxidant potential KW - intestinal model KW - cellular uptake KW - isothiocyanate Y1 - 2022 U6 - https://doi.org/10.3389/fnut.2022.941286 SN - 2296-861X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - BOOK A1 - Meinel, Christoph A1 - Renz, Jan A1 - Luderich, Matthias A1 - Malyska, Vivien A1 - Kaiser, Konstantin A1 - Oberländer, Arne T1 - Die HPI Schul-Cloud BT - Roll-Out einer Cloud-Architektur für Schulen in Deutschland N2 - Die digitale Transformation durchdringt alle gesellschaftlichen Ebenen und Felder, nicht zuletzt auch das Bildungssystem. Dieses ist auf die Veränderungen kaum vorbereitet und begegnet ihnen vor allem auf Basis des Eigenengagements seiner Lehrer*innen. Strukturelle Reaktionen auf den Mangel an qualitativ hochwertigen Fortbildungen, auf schlecht ausgestattete Unterrichtsräume und nicht professionell gewartete Computersysteme gibt es erst seit kurzem. Doch auch wenn Beharrungskräfte unter Pädagog*innen verbreitet sind, erfordert die Transformation des Systems Schule auch eine neue Mentalität und neue Arbeits- und Kooperationsformen. Zeitgemäßer Unterricht benötigt moderne Technologie und zeitgemäße IT-Architekturen. Nur Systeme, die für Lehrer*innen und Schüler*innen problemlos verfügbar, benutzerfreundlich zu bedienen und didaktisch flexibel einsetzbar sind, finden in Schulen Akzeptanz. Hierfür haben wir die HPI Schul-Cloud entwickelt. Sie ermöglicht den einfachen Zugang zu neuesten, professionell gewarteten Anwendungen, verschiedensten digitalen Medien, die Vernetzung verschiedener Lernorte und den rechtssicheren Einsatz von Kommunikations- und Kollaborationstools. Die Entwicklung der HPI Schul-Cloud ist umso notwendiger, als dass rechtliche Anforderungen - insbesondere aus der Datenschutzgrundverordnung der EU herrührend - den Einsatz von Cloud-Anwendungen, die in der Arbeitswelt verbreitet sind, in Schulen unmöglich machen. Im Bildungsbereich verbreitete Anwendungen sind größtenteils technisch veraltet und nicht benutzerfreundlich. Dies nötigt die Bundesländer zu kostspieligen Eigenentwicklungen mit Aufwänden im zweistelligen Millionenbereich - Projekte die teilweise gescheitert sind. Dank der modularen Micro-Service-Architektur können die Bundesländer zukünftig auf die HPI Schul-Cloud als technische Grundlage für ihre Eigen- oder Gemeinschaftsprojekte zurückgreifen. Hierfür gilt es, eine nachhaltige Struktur für die Weiterentwicklung der Open-Source-Software HPI Schul-Cloud zu schaffen. Dieser Bericht beschreibt den Entwicklungsstand und die weiteren Perspektiven des Projekts HPI Schul-Cloud im Januar 2019. 96 Schulen deutschlandweit nutzen die HPI Schul-Cloud, bereitgestellt durch das Hasso-Plattner-Institut. Weitere 45 Schulen und Studienseminare nutzen die Niedersächsische Bildungscloud, die technisch auf der HPI Schul-Cloud basiert. Das vom Bundesministerium für Bildung und Forschung geförderte Projekt läuft in der gegenwärtigen Roll-Out-Phase bis zum 31. Juli 2021. Gemeinsam mit unserem Kooperationspartner MINT-EC streben wir an, die HPI Schul-Cloud möglichst an allen Schulen des Netzwerks einzusetzen. N2 - Digital transformation affects all social levels and fields, as well as the education system. It is hardly prepared for the changes and meets them primarily on the basis of the personal commitment of its teachers. Structural reactions to the lack of high-quality further training, poorly equipped classrooms and computer systems that are not professionally maintained have only recently emerged. However, while persistent efforts among educators are also widespread, the transformation of the school system requires a new mindset and new forms of work and cooperation. Contemporary teaching requires modern technology and modern IT architectures. Only systems that are effortlessly available for teachers and students, user-friendly and didactically flexible will find acceptance in schools. For this purpose, we have developed the HPI Schul-Cloud. It provides easy access to the latest professionally maintained applications, a wide variety of digital media, the networking of different learning locations and the legally compliant use of communication and collaboration tools. The development of the HPI Schul-Cloud is all the more necessary because legal requirements - particularly those arising from the EU’s General Data Protection Regulation (GDPR) - make it impossible to use cloud applications, which are common in modern working places, in schools. The most common educational applications are to a large degree technically outdated and not user-friendly. This deficiency forces federal states to develop their own costly applications with expenses in the tens of millions - projects that have partly failed. Thanks to the modular micro-service architecture, the federal states will be able to use the HPI Schul-Cloud as the technical basis for their own or joint projects in the future. The aim here is to create a sustainable structure for the further development of the open source software HPI Schul-Cloud. This report describes the development status and further perspectives of the HPI Schul-Cloud project in January 2019. 96 schools across Germany use the HPI Schul-Cloud, provided by the Hasso-Plattner-Institute. A further 45 schools and study seminars use the Niedersächsische Bildungscloud, which is technically based on the HPI Schul-Cloud. The project, which is funded by the German Federal Ministry of Education and Research, is currently being rolled out until July 31, 2021. Together with our cooperation partner MINT-EC we aim to use the HPI Schul-Cloud possibly at all schools in the network. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 125 KW - digitale Bildung KW - Schule KW - IT-Infrastruktur KW - Cloud KW - German schools KW - digital education KW - IT-infrastructure KW - cloud Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-423062 SN - 978-3-86956-453-1 SN - 1613-5652 SN - 2191-1665 IS - 125 PB - Universitätsverlag Potsdam CY - Potsdam ER -