TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Hetenyi, Gyorgy
A1  - Molinari, Irene
A1  - Clinton, John
A1  - Bokelmann, Gotz
A1  - Bondar, Istvan
A1  - Crawford, Wayne C.
A1  - Dessa, Jean-Xavier
A1  - Doubre, Cecile
A1  - Friederich, Wolfgang
A1  - Fuchs, Florian
A1  - Giardini, Domenico
A1  - Graczer, Zoltan
A1  - Handy, Mark R.
A1  - Herak, Marijan
A1  - Jia, Yan
A1  - Kissling, Edi
A1  - Kopp, Heidrun
A1  - Korn, Michael
A1  - Margheriti, Lucia
A1  - Meier, Thomas
A1  - Mucciarelli, Marco
A1  - Paul, Anne
A1  - Pesaresi, Damiano
A1  - Piromallo, Claudia
A1  - Plenefisch, Thomas
A1  - Plomerova, Jaroslava
A1  - Ritter, Joachim
A1  - Rumpker, Georg
A1  - Sipka, Vesna
A1  - Spallarossa, Daniele
A1  - Thomas, Christine
A1  - Tilmann, Frederik
A1  - Wassermann, Joachim
A1  - Weber, Michael
A1  - Weber, Zoltan
A1  - Wesztergom, Viktor
A1  - Zivcic, Mladen
A1  - Abreu, Rafael
A1  - Allegretti, Ivo
A1  - Apoloner, Maria-Theresia
A1  - Aubert, Coralie
A1  - Besancon, Simon
A1  - de Berc, Maxime Bes
A1  - Brunel, Didier
A1  - Capello, Marco
A1  - Carman, Martina
A1  - Cavaliere, Adriano
A1  - Cheze, Jerome
A1  - Chiarabba, Claudio
A1  - Cougoulat, Glenn
A1  - Cristiano, Luigia
A1  - Czifra, Tibor
A1  - Danesi, Stefania
A1  - Daniel, Romuald
A1  - Dannowski, Anke
A1  - Dasovic, Iva
A1  - Deschamps, Anne
A1  - Egdorf, Sven
A1  - Fiket, Tomislav
A1  - Fischer, Kasper
A1  - Funke, Sigward
A1  - Govoni, Aladino
A1  - Groschl, Gidera
A1  - Heimers, Stefan
A1  - Heit, Ben
A1  - Herak, Davorka
A1  - Huber, Johann
A1  - Jaric, Dejan
A1  - Jedlicka, Petr
A1  - Jund, Helene
A1  - Klingen, Stefan
A1  - Klotz, Bernhard
A1  - Kolinsky, Petr
A1  - Kotek, Josef
A1  - Kuhne, Lothar
A1  - Kuk, Kreso
A1  - Lange, Dietrich
A1  - Loos, Jurgen
A1  - Lovati, Sara
A1  - Malengros, Deny
A1  - Maron, Christophe
A1  - Martin, Xavier
A1  - Massa, Marco
A1  - Mazzarini, Francesco
A1  - Metral, Laurent
A1  - Moretti, Milena
A1  - Munzarova, Helena
A1  - Nardi, Anna
A1  - Pahor, Jurij
A1  - Pequegnat, Catherine
A1  - Petersen, Florian
A1  - Piccinini, Davide
A1  - Pondrelli, Silvia
A1  - Prevolnik, Snjezan
A1  - Racine, Roman
A1  - Regnier, Marc
A1  - Reiss, Miriam
A1  - Salimbeni, Simone
A1  - Santulin, Marco
A1  - Scherer, Werner
A1  - Schippkus, Sven
A1  - Schulte-Kortnack, Detlef
A1  - Solarino, Stefano
A1  - Spieker, Kathrin
A1  - Stipcevic, Josip
A1  - Strollo, Angelo
A1  - Sule, Balint
A1  - Szanyi, Gyongyver
A1  - Szucs, Eszter
A1  - Thorwart, Martin
A1  - Ueding, Stefan
A1  - Vallocchia, Massimiliano
A1  - Vecsey, Ludek
A1  - Voigt, Rene
A1  - Weidle, Christian
A1  - Weyland, Gauthier
A1  - Wiemer, Stefan
A1  - Wolf, Felix
A1  - Wolyniec, David
A1  - Zieke, Thomas
T1  - The AlpArray seismic network
BT  - a large-scale european experiment to image the alpine orogen
JF  - Surveys in Geophysics
N2  - The AlpArray programme is a multinational, European consortium to advance our understanding of orogenesis and its relationship to mantle dynamics, plate reorganizations, surface processes and seismic hazard in the Alps-Apennines-Carpathians-Dinarides orogenic system. The AlpArray Seismic Network has been deployed with contributions from 36 institutions from 11 countries to map physical properties of the lithosphere and asthenosphere in 3D and thus to obtain new, high-resolution geophysical images of structures from the surface down to the base of the mantle transition zone. With over 600 broadband stations operated for 2 years, this seismic experiment is one of the largest simultaneously operated seismological networks in the academic domain, employing hexagonal coverage with station spacing at less than 52 km. This dense and regularly spaced experiment is made possible by the coordinated coeval deployment of temporary stations from numerous national pools, including ocean-bottom seismometers, which were funded by different national agencies. They combine with permanent networks, which also required the cooperation of many different operators. Together these stations ultimately fill coverage gaps. Following a short overview of previous large-scale seismological experiments in the Alpine region, we here present the goals, construction, deployment, characteristics and data management of the AlpArray Seismic Network, which will provide data that is expected to be unprecedented in quality to image the complex Alpine mountains at depth.
KW  - Seismology
KW  - Alps
KW  - Seismic network
KW  - Geodynamics
KW  - Seismic imaging
KW  - Mountain building
Y1  - 2018
U6  - https://doi.org/10.1007/s10712-018-9472-4
SN  - 0169-3298
SN  - 1573-0956
VL  - 39
IS  - 5
SP  - 1009
EP  - 1033
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Beye, Martin
A1  - Öberg, Henrik
A1  - Xin, Hongliang
A1  - Dakovski, Georgi L.
A1  - Föhlisch, Alexander
A1  - Gladh, Jorgen
A1  - Hantschmann, Markus
A1  - Hieke, Florian
A1  - Kaya, Sarp
A1  - Kühn, Danilo
A1  - LaRue, Jerry
A1  - Mercurio, Giuseppe
A1  - Minitti, Michael P.
A1  - Mitra, Ankush
A1  - Moeller, Stefan P.
A1  - Ng, May Ling
A1  - Nilsson, Anders
A1  - Nordlund, Dennis
A1  - Norskov, Jens
A1  - Öström, Henrik
A1  - Ogasawara, Hirohito
A1  - Persson, Mats
A1  - Schlotter, William F.
A1  - Sellberg, Jonas A.
A1  - Wolf, Martin
A1  - Abild-Pedersen, Frank
A1  - Pettersson, Lars G. M.
A1  - Wurth, Wilfried
T1  - Chemical Bond Activation Observed with an X-ray Laser
JF  - The journal of physical chemistry letters
N2  - The concept of bonding and antibonding orbitals is fundamental in chemistry. The population of those orbitals and the energetic difference between the two reflect the strength of the bonding interaction. Weakening the bond is expected to reduce this energetic splitting, but the transient character of bond-activation has so far prohibited direct experimental access. Here we apply time-resolved soft X-ray spectroscopy at a free electron laser to directly observe the decreased bonding antibonding splitting following bond-activation using an ultrashort optical laser pulse.
Y1  - 2016
U6  - https://doi.org/10.1021/acs.jpclett.6b01543
SN  - 1948-7185
VL  - 7
SP  - 3647
EP  - 3651
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Xin, Hong
A1  - LaRue, Jerry
A1  - Oberg, Henrik
A1  - Beye, Martin
A1  - Turner, J. J.
A1  - Gladh, Jörgen
A1  - Ng, May L.
A1  - Sellberg, Jonas A.
A1  - Kaya, Sarp
A1  - Mercurio, G.
A1  - Hieke, F.
A1  - Nordlund, Dennis
A1  - Schlotter, William F.
A1  - Dakovski, Georgi L.
A1  - Minitti, Michael P.
A1  - Föhlisch, Alexander
A1  - Wolf, Martin
A1  - Wurth, Wilfried
A1  - Ogasawara, Hirohito
A1  - Norskov, Jens K.
A1  - Ostrom, Henrik
A1  - Pettersson, Lars G. M.
A1  - Nilsson, Anders
A1  - Abild-Pedersen, Frank
T1  - Strong Influence of Coadsorbate Interaction on CO Desorption Dynamics on Ru(0001) Probed by Ultrafast X-Ray Spectroscopy and Ab Initio Simulations
JF  - Physical review letters
N2  - We show that coadsorbed oxygen atoms have a dramatic influence on the CO desorption dynamics from Ru(0001). In contrast to the precursor-mediated desorption mechanism on Ru(0001), the presence of surface oxygen modifies the electronic structure of Ru atoms such that CO desorption occurs predominantly via the direct pathway. This phenomenon is directly observed in an ultrafast pump-probe experiment using a soft x-ray free-electron laser to monitor the dynamic evolution of the valence electronic structure of the surface species. This is supported with the potential of mean force along the CO desorption path obtained from density-functional theory calculations. Charge density distribution and frozen-orbital analysis suggest that the oxygen-induced reduction of the Pauli repulsion, and consequent increase of the dative interaction between the CO 5 sigma and the charged Ru atom, is the electronic origin of the distinct desorption dynamics. Ab initio molecular dynamics simulations of CO desorption from Ru(0001) and oxygen-coadsorbed Ru(0001) provide further insights into the surface bond-breaking process.
Y1  - 2015
U6  - https://doi.org/10.1103/PhysRevLett.114.156101
SN  - 0031-9007
SN  - 1079-7114
VL  - 114
IS  - 15
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Oberg, H.
A1  - Gladh, Jörgen
A1  - Anniyev, Toyli
A1  - Beye, Martin
A1  - Coffee, Ryan
A1  - Föhlisch, Alexander
A1  - Katayama, T.
A1  - Kaya, Sarp
A1  - LaRue, Jerry
A1  - Mogelhoj, Andreas
A1  - Nordlund, Dennis
A1  - Ogasawara, Hirohito
A1  - Schlotter, William F.
A1  - Sellberg, Jonas A.
A1  - Sorgenfrei, Nomi
A1  - Turner, Joshua J.
A1  - Wolf, Martin
A1  - Wurth, W.
A1  - Ostrom, Henrik
A1  - Nilsson, Anders
A1  - Norskov, Jens K.
A1  - Pettersson, Lars G. M.
T1  - Optical laser-induced CO desorption from Ru(0001) monitored with a free-electron X-ray laser: DFT prediction and X-ray confirmation of a precursor state
JF  - Surface science
N2  - We present density functional theory modeling of time-resolved optical pump/X-ray spectroscopic probe data of CO desorption from Ru(0001). The BEEF van der Waals functional predicts a weakly bound state as a precursor to desorption. The optical pump leads to a near-instantaneous (<100 fs) increase of the electronic temperature to nearly 7000 K. The temperature evolution and energy transfer between electrons, substrate phonons and adsorbate is described by the two-temperature model and found to equilibrate on a timescale of a few picoseconds to an elevated local temperature of similar to 2000K. Estimating the free energy based on the computed potential of mean force along the desorption path, we find an entropic barrier to desorption (and by time-reversal also to adsorption). This entropic barrier separates the chemisorbed and precursor states, and becomes significant at the elevated temperature of the experiment (similar to 1.4 eV at 2000 K). Experimental pump-probe X-ray absorption/X-ray emission spectroscopy indicates population of a precursor state to desorption upon laser-excitation of the system (Dell'Angela et al., 2013). Computing spectra along the desorption path confirms the picture of a weakly bound transient state arising from ultrafast heating of the metal substrate. (C) 2015 Elsevier B.V. All rights reserved.
KW  - CO desorption
KW  - Potential of mean force
KW  - Two-temperature model
KW  - Pump-probe
KW  - X-ray spectroscopy
KW  - Density functional theory
Y1  - 2015
U6  - https://doi.org/10.1016/j.susc.2015.03.011
SN  - 0039-6028
SN  - 1879-2758
VL  - 640
SP  - 80
EP  - 88
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Neumann, Bernhard
A1  - Horstkemper, Marianne
A1  - Krüger, Wolfgang
A1  - Wilkens, Martin
A1  - Bohlen, Andreas
A1  - Frübing, Peter
A1  - Wegener, Michael
A1  - Scheff, Ullrich
A1  - Neher, Dieter
A1  - Brehmer, Ludwig
A1  - Kleinpeter, Erich
A1  - Wolf, Gunter
A1  - Koetz, Joachim
A1  - Peter, Martin G.
A1  - Senkbeil, Sigrid
A1  - Meyer, Till
T1  - Portal = Im Trend: Physiker und Chemiker erforschen "Soft Matter"
BT  - Die Potsdamer Universitätszeitung
N2  - Aus dem Inhalt:
Im Trend: Physiker und Chemiker erforschen „Soft Matter“
-Brandenburger Netzwerk für Existenzgründer erhält Förderung
-Universität leistet Beitrag zum Romantik-Jahr
-Musiksender MTV und Bryan Adams auf dem Campus
T3  - Portal: Das Potsdamer Universitätsmagazin - 06/2002 
Y1  - 2002
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-501441
SN  - 1618-6893
VL  - 2002
ER  - 
TY  - JOUR
A1  - Dell'Angela, Martina
A1  - Anniyev, Toyli
A1  - Beye, Martin
A1  - Coffee, Ryan
A1  - Föhlisch, Alexander
A1  - Gladh, Jörgen
A1  - Kaya, Sarp
A1  - Katayama, Tetsuo
A1  - Krupin, Oleg
A1  - Nilsson, Anders
A1  - Nordlund, Dennis
A1  - Schlotter, William F.
A1  - Sellberg, Jonas A.
A1  - Sorgenfrei, Nomi
A1  - Turner, Joshua J.
A1  - ÖstrÖm, Henrik
A1  - Ogasawara, Hirohito
A1  - Wolf, Martin
A1  - Wurth, Wilfried
T1  - Vacuum space charge effects in sub-picosecond soft X-ray photoemission on a molecular adsorbate layer
JF  - Structural dynamics
N2  - Vacuum space charge induced kinetic energy shifts of O 1s and Ru 3d core levels in femtosecond soft X-ray photoemission spectra (PES) have been studied at a free electron laser (FEL) for an oxygen layer on Ru(0001). We fully reproduced the measurements by simulating the in-vacuum expansion of the photoelectrons and demonstrate the space charge contribution of the high-order harmonics in the FEL beam. Employing the same analysis for 400 nm pump-X-ray probe PES, we can disentangle the delay dependent Ru 3d energy shifts into effects induced by space charge and by lattice heating from the femtosecond pump pulse. (C) 2015 Author(s).
Y1  - 2015
U6  - https://doi.org/10.1063/1.4914892
SN  - 2329-7778
VL  - 2
IS  - 2
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Wilkin, Kyle J.
A1  - Parrish, Robert M.
A1  - Yang, Jie
A1  - Wolf, Thomas J. A.
A1  - Nunes, J. Pedro F.
A1  - Gühr, Markus
A1  - Li, Renkai
A1  - Shen, Xiaozhe
A1  - Zheng, Qiang
A1  - Wang, Xijie
A1  - Martinez, Todd J.
A1  - Centurion, Martin
T1  - Diffractive imaging of dissociation and ground-state dynamics in a complex molecule
JF  - Physical review : A, Atomic, molecular, and optical physics
N2  - We have investigated the structural dynamics in photoexcited 1,2-diiodotetrafluoroethane molecules (C2F4I2) in the gas phase experimentally using ultrafast electron diffraction and theoretically using FOMO-CASCI excited-state dynamics simulations. The molecules are excited by an ultraviolet femtosecond laser pulse to a state characterized by a transition from the iodine 5p perpendicular to orbital to a mixed 5p parallel to sigma hole and CF2 center dot antibonding orbital, which results in the cleavage of one of the carbon-iodine bonds. We have observed, with sub-Angstrom resolution, the motion of the nuclear wave packet of the dissociating iodine atom followed by coherent vibrations in the electronic ground state of the C2F4I radical. The radical reaches a stable classical (nonbridged) structure in less than 200 fs.
Y1  - 2019
U6  - https://doi.org/10.1103/PhysRevA.100.023402
SN  - 2469-9926
SN  - 2469-9934
VL  - 100
IS  - 2
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Boecker-Schlier, Regina
A1  - Holz, Nathalie E.
A1  - Hohm, Erika
A1  - Zohsel, Katrin
A1  - Blomeyer, Dorothea
A1  - Buchmann, Arlette F.
A1  - Baumeister, Sarah
A1  - Wolf, Isabella
A1  - Esser, Günter
A1  - Schmidt, Martin H.
A1  - Meyer-Lindenberg, Andreas
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Association between pubertal stage at first drink and neural reward processing in early adulthood
JF  - Addiction biology
N2  - Puberty is a critical time period during human development. It is characterized by high levels of risk-taking behavior, such as increased alcohol consumption, and is accompanied by various neurobiological changes. Recent studies in animals and humans have revealed that the pubertal stage at first drink (PSFD) significantly impacts drinking behavior in adulthood. Moreover, neuronal alterations of the dopaminergic reward system have been associated with alcohol abuse or addiction. This study aimed to clarify the impact of PSFD on neuronal characteristics of reward processing linked to alcohol-related problems. One hundred sixty-eight healthy young adults from a prospective study covering 25 years participated in a monetary incentive delay task measured with simultaneous EEG-fMRI. PSFD was determined according to the age at menarche or Tanner stage of pubertal development, respectively. Alcohol-related problems in early adulthood were assessed with the Alcohol Use Disorder Identification Test (AUDIT). During reward anticipation, decreased fMRI activation of the frontal cortex and increased preparatory EEG activity (contingent negative variation) occurred with pubertal compared to postpubertal first alcohol intake. Moreover, alcohol-related problems during early adulthood were increased in pubertal compared to postpubertal beginners, which was mediated by neuronal activation of the right medial frontal gyrus. At reward delivery, increased fMRI activation of the left caudate and higher feedback-related EEG negativity were detected in pubertal compared to postpubertal beginners. Together with animal findings, these results implicate PSFD as a potential modulator of psychopathology, involving altered reward anticipation. Both PSFD timing and reward processing might thus be potential targets for early prevention and intervention.
KW  - alcohol-related problems
KW  - electroencephalography
KW  - functional magnetic resonance imaging
KW  - puberty
KW  - reward processing
Y1  - 2017
U6  - https://doi.org/10.1111/adb.12413
SN  - 1355-6215
SN  - 1369-1600
VL  - 22
SP  - 1402
EP  - 1415
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Yang, Jie
A1  - Zhu, Xiaolei
A1  - Wolf, Thomas J. A.
A1  - Li, Zheng
A1  - Nunes, João Pedro Figueira
A1  - Coffee, Ryan
A1  - Cryan, James P.
A1  - Gühr, Markus
A1  - Hegazy, Kareem
A1  - Heinz, Tony F.
A1  - Jobe, Keith
A1  - Li, Renkai
A1  - Shen, Xiaozhe
A1  - Veccione, Theodore
A1  - Weathersby, Stephen
A1  - Wilkin, Kyle J.
A1  - Yoneda, Charles
A1  - Zheng, Qiang
A1  - Martinez, Todd J.
A1  - Centurion, Martin
A1  - Wang, Xijie
T1  - Imaging CF3I conical intersection and photodissociation dynamics with ultrafast electron diffraction
JF  - Science
N2  - Conical intersections play a critical role in excited-state dynamics of polyatomic molecules because they govern the reaction pathways of many nonadiabatic processes. However, ultrafast probes have lacked sufficient spatial resolution to image wave-packet trajectories through these intersections directly. Here, we present the simultaneous experimental characterization of one-photon and two-photon excitation channels in isolated CF3I molecules using ultrafast gas-phase electron diffraction. In the two-photon channel, we have mapped out the real-space trajectories of a coherent nuclear wave packet, which bifurcates onto two potential energy surfaces when passing through a conical intersection. In the one-photon channel, we have resolved excitation of both the umbrella and the breathing vibrational modes in the CF3 fragment in multiple nuclear dimensions. These findings benchmark and validate ab initio nonadiabatic dynamics calculations.
Y1  - 2018
U6  - https://doi.org/10.1126/science.aat0049
SN  - 0036-8075
SN  - 1095-9203
VL  - 361
IS  - 6397
SP  - 64
EP  - 67
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - GEN
A1  - Anderson, Christopher J.
A1  - Bahnik, Stepan
A1  - Barnett-Cowan, Michael
A1  - Bosco, Frank A.
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cordes, Andreas
A1  - Cremata, Edward J.
A1  - Della Penna, Nicolas
A1  - Estel, Vivien
A1  - Fedor, Anna
A1  - Fitneva, Stanka A.
A1  - Frank, Michael C.
A1  - Grange, James A.
A1  - Hartshorne, Joshua K.
A1  - Hasselman, Fred
A1  - Henninger, Felix
A1  - van der Hulst, Marije
A1  - Jonas, Kai J.
A1  - Lai, Calvin K.
A1  - Levitan, Carmel A.
A1  - Miller, Jeremy K.
A1  - Moore, Katherine S.
A1  - Meixner, Johannes M.
A1  - Munafo, Marcus R.
A1  - Neijenhuijs, Koen I.
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Ricker, Ashley A.
A1  - Schmidt, Kathleen
A1  - Spies, Jeffrey R.
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - van Aert, Robbie C. M.
A1  - van Assen, Marcel A. L. M.
A1  - Vanpaemel, Wolf
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Zuni, Kellylynn
T1  - Response to Comment on "Estimating the reproducibility of psychological science"
T2  - Science
N2  - Gilbert et al. conclude that evidence from the Open Science Collaboration’s Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted.
Y1  - 2016
U6  - https://doi.org/10.1126/science.aad9163
SN  - 0036-8075
SN  - 1095-9203
VL  - 351
SP  - 1162
EP  - 1165
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Ostrom, H.
A1  - Oberg, H.
A1  - Xin, H.
A1  - Larue, J.
A1  - Beye, Martin
A1  - Gladh, J.
A1  - Ng, M. L.
A1  - Sellberg, J. A.
A1  - Kaya, S.
A1  - Mercurio, G.
A1  - Nordlund, D.
A1  - Hantschmann, Markus
A1  - Hieke, F.
A1  - Kuehn, D.
A1  - Schlotter, W. F.
A1  - Dakovski, G. L.
A1  - Turner, J. J.
A1  - Minitti, M. P.
A1  - Mitra, A.
A1  - Moeller, S. P.
A1  - Föhlisch, Alexander
A1  - Wolf, M.
A1  - Wurth, W.
A1  - Persson, Mats
A1  - Norskov, J. K.
A1  - Abild-Pedersen, Frank
A1  - Ogasawara, Hirohito
A1  - Pettersson, Lars G. M.
A1  - Nilsson, A.
T1  - Probing the transition state region in catalytic CO oxidation on Ru
JF  - Science
N2  - Femtosecond x-ray laser pulses are used to probe the carbon monoxide (CO) oxidation reaction on ruthenium (Ru) initiated by an optical laser pulse. On a time scale of a few hundred femtoseconds, the optical laser pulse excites motions of CO and oxygen (O) on the surface, allowing the reactants to collide, and, with a transient close to a picosecond (ps), new electronic states appear in the OK-edge x-ray absorption spectrum. Density functional theory calculations indicate that these result from changes in the adsorption site and bond formation between CO and O with a distribution of OC-O bond lengths close to the transition state (TS). After 1 ps, 10% of the CO populate the TS region, which is consistent with predictions based on a quantum oscillator model.
Y1  - 2015
U6  - https://doi.org/10.1126/science.1261747
SN  - 0036-8075
SN  - 1095-9203
VL  - 347
IS  - 6225
SP  - 978
EP  - 982
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - GEN
A1  - Guske, Anna-Lena
A1  - Jacob, Klaus
A1  - Hirschnitz-Garbers, Martin
A1  - Peuckert, Jan
A1  - Schridde, Stefan
A1  - Stinner, Sven
A1  - Wolf, Franziska
A1  - Zahrnt, Dominik
A1  - Ziesemer, Florence
T1  - Stories that change our world?
BT  - Narratives of the sustainable economy
T2  - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe
N2  - Narratives are shaping our understanding of the world. They convey values and norms and point to desirable future developments. In this way, they justify and legitimize political actions and social practices. Once a narrative has emerged and this world view is supported by broad societal groups, narratives can provide powerful momentum to trigger innovation and changes in the course of action. Narratives, however, are not necessarily based on evidence and precise categories, but can instead be vague and ambiguous in order to be acceptable and attractive to different actors. However, the more open and inclusive a narrative is, the less impact can be expected. We investigate whether there is a shared narrative in research for the sustainable economy and how this can be evaluated in terms of its potential societal impact. The paper carves out the visions for the future that have been underlying the research projects conducted within the German Federal Ministry of Education and Research (BMBF) funding programme "The Sustainable Economy". It then analyzes whether these visions are compatible with narratives dominating societal discourse on the sustainable economy, and concludes how the use of visions and narratives in research can contribute to fostering societal transformations.
T3  - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe - 162 
KW  - narratives
KW  - sustainable economy
KW  - societal impact of research
KW  - research communication
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-472783
SN  - 1867-5808
IS  - 612
ER  - 
TY  - JOUR
A1  - Henning, Ursula
A1  - Wolf, Peter
A1  - Holtzhauer, Martin
T1  - Primary cultures of cardiac muscle cells as models for investigation of protein glycosylation
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Keller, Johannes
A1  - Catala-Lehnen, Philip
A1  - Huebner, Antje K.
A1  - Jeschke, Anke
A1  - Heckt, Timo
A1  - Lueth, Anja
A1  - Krause, Matthias
A1  - Koehne, Till
A1  - Albers, Joachim
A1  - Schulze, Jochen
A1  - Schilling, Sarah
A1  - Haberland, Michael
A1  - Denninger, Hannah
A1  - Neven, Mona
A1  - Hermans-Borgmeyer, Irm
A1  - Streichert, Thomas
A1  - Breer, Stefan
A1  - Barvencik, Florian
A1  - Levkau, Bodo
A1  - Rathkolb, Birgit
A1  - Wolf, Eckhard
A1  - Calzada-Wack, Julia
A1  - Neff, Frauke
A1  - Gailus-Durner, Valerie
A1  - Fuchs, Helmut
A1  - de Angelis, Martin Hrabe
A1  - Klutmann, Susanne
A1  - Tsourdi, Elena
A1  - Hofbauer, Lorenz C.
A1  - Kleuser, Burkhard
A1  - Chun, Jerold
A1  - Schinke, Thorsten
A1  - Amling, Michael
T1  - Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
JF  - Nature Communications
N2  - The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclast-specific inactivation of the murine CT receptor (CTR) causes increased bone formation. CT negatively regulates the osteoclast expression of Spns2 gene, which encodes a transporter for the signalling lipid sphingosine 1-phosphate (S1P). CTR-deficient mice show increased S1P levels, and their skeletal phenotype is normalized by deletion of the S1P receptor S1P(3). Finally, pharmacologic treatment with the nonselective S1P receptor agonist FTY720 causes increased bone formation in wild-type, but not in S1P(3)-deficient mice. This study redefines the role of CT in skeletal biology, confirms that S1P acts as an osteoanabolic molecule in vivo and provides evidence for a pharmacologically exploitable crosstalk between osteoclasts and osteoblasts.
Y1  - 2014
U6  - https://doi.org/10.1038/ncomms6215
SN  - 2041-1723
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Janssen, Annette B. G.
A1  - Arhonditsis, George B.
A1  - Beusen, Arthur
A1  - Bolding, Karsten
A1  - Bruce, Louise
A1  - Bruggeman, Jorn
A1  - Couture, Raoul-Marie
A1  - Downing, Andrea S.
A1  - Elliott, J. Alex
A1  - Frassl, Marieke A.
A1  - Gal, Gideon
A1  - Gerla, Daan J.
A1  - Hipsey, Matthew R.
A1  - Hu, Fenjuan
A1  - Ives, Stephen C.
A1  - Janse, Jan H.
A1  - Jeppesen, Erik
A1  - Joehnk, Klaus D.
A1  - Kneis, David
A1  - Kong, Xiangzhen
A1  - Kuiper, Jan J.
A1  - Lehmann, Moritz K.
A1  - Lemmen, Carsten
A1  - Oezkundakci, Deniz
A1  - Petzoldt, Thomas
A1  - Rinke, Karsten
A1  - Robson, Barbara J.
A1  - Sachse, Rene
A1  - Schep, Sebastiaan A.
A1  - Schmid, Martin
A1  - Scholten, Huub
A1  - Teurlincx, Sven
A1  - Trolle, Dennis
A1  - Troost, Tineke A.
A1  - Van Dam, Anne A.
A1  - Van Gerven, Luuk P. A.
A1  - Weijerman, Mariska
A1  - Wells, Scott A.
A1  - Mooij, Wolf M.
T1  - Exploring, exploiting and evolving diversity of aquatic ecosystem models: a community perspective
JF  - Aquatic ecology : the international forum covering research in freshwater and marine environments
N2  - Here, we present a community perspective on how to explore, exploit and evolve the diversity in aquatic ecosystem models. These models play an important role in understanding the functioning of aquatic ecosystems, filling in observation gaps and developing effective strategies for water quality management. In this spirit, numerous models have been developed since the 1970s. We set off to explore model diversity by making an inventory among 42 aquatic ecosystem modellers, by categorizing the resulting set of models and by analysing them for diversity. We then focus on how to exploit model diversity by comparing and combining different aspects of existing models. Finally, we discuss how model diversity came about in the past and could evolve in the future. Throughout our study, we use analogies from biodiversity research to analyse and interpret model diversity. We recommend to make models publicly available through open-source policies, to standardize documentation and technical implementation of models, and to compare models through ensemble modelling and interdisciplinary approaches. We end with our perspective on how the field of aquatic ecosystem modelling might develop in the next 5-10 years. To strive for clarity and to improve readability for non-modellers, we include a glossary.
KW  - Water quality
KW  - Ecology
KW  - Geochemistry
KW  - Hydrology
KW  - Hydraulics
KW  - Hydrodynamics
KW  - Physical environment
KW  - Socio-economics
KW  - Model availability
KW  - Standardization
KW  - Linking
Y1  - 2015
U6  - https://doi.org/10.1007/s10452-015-9544-1
SN  - 1386-2588
SN  - 1573-5125
VL  - 49
IS  - 4
SP  - 513
EP  - 548
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Holz, Nathalie
A1  - Boecker-Schlier, Regina
A1  - Buchmann, Arlette F.
A1  - Blomeyer, Dorothea
A1  - Baumeister, Sarah
A1  - Hohmann, Sarah
A1  - Jennen-Steinmetz, Christine
A1  - Wolf, Isabella
A1  - Rietschel, Marcella
A1  - Witt, Stephanie H.
A1  - Plichta, Michael M.
A1  - Meyer-Lindenberg, Andreas
A1  - Schmidt, Martin H.
A1  - Esser, Günter
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Evidence for a Sex-Dependent MAOAx Childhood Stress Interaction in the Neural Circuitry of Aggression
JF  - Cerebral cortex
N2  - Converging evidence emphasizes the role of an interaction between monoamine oxidase A (MAOA) genotype, environmental adversity, and sex in the pathophysiology of aggression. The present study aimed to clarify the impact of this interaction on neural activity in aggression-related brain systems. Functional magnetic resonance imaging was performed in 125 healthy adults from a high-risk community sample followed since birth. DNA was genotyped for the MAOA-VNTR (variable number of tandem repeats). Exposure to childhood life stress (CLS) between the ages of 4 and 11 years was assessed using a standardized parent interview, aggression by the Youth/Young Adult Self-Report between the ages of 15 and 25 years, and the VIRA-R (Vragenlijst Instrumentele En Reactieve Agressie) at the age of 15 years. Significant interactions were obtained between MAOA genotype, CLS, and sex relating to amygdala, hippocampus, and anterior cingulate cortex (ACC) response, respectively. Activity in the amygdala and hippocampus during emotional face-matching increased with the level of CLS in male MAOA-L, while decreasing in male MAOA-H, with the reverse pattern present in females. Findings in the opposite direction in the ACC during a flanker NoGo task suggested that increased emotional activity coincided with decreased inhibitory control. Moreover, increasing amygdala activity was associated with higher Y(A)SR aggression in male MAOA-L and female MAOA-H carriers. Likewise, a significant association between amygdala activity and reactive aggression was detected in female MAOA-H carriers. The results point to a moderating role of sex in the MAOAx CLS interaction for intermediate phenotypes of emotional and inhibitory processing, suggesting a possible mechanism in conferring susceptibility to violence-related disorders.
KW  - aggression
KW  - amygdala
KW  - fMRI
KW  - life stress
KW  - MAOA
Y1  - 2016
U6  - https://doi.org/10.1093/cercor/bhu249
SN  - 1047-3211
SN  - 1460-2199
VL  - 26
SP  - 904
EP  - 914
PB  - Oxford Univ. Press
CY  - Cary
ER  - 
TY  - JOUR
A1  - Holz, Nathalie E.
A1  - Boecker-Schlier, Regina
A1  - Hohm, Erika
A1  - Zohsel, Katrin
A1  - Buchmann, Arlette F.
A1  - Blomeyer, Dorothea
A1  - Jennen-Steinmetz, Christine
A1  - Baumeister, Sarah
A1  - Hohmann, Sarah
A1  - Wolf, Isabella
A1  - Plichta, Michael M.
A1  - Esser, Günter
A1  - Schmidt, Martin
A1  - Meyer-Lindenberg, Andreas
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - The Long-Term Impact of Early Life Poverty on Orbitofrontal Cortex Volume in Adulthood: Results from a Prospective Study Over 25 Years
JF  - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
N2  - Converging evidence has highlighted the association between poverty and conduct disorder (CD) without specifying neurobiological pathways. Neuroimaging research has emphasized structural and functional alterations in the orbitofrontal cortex (OFC) as one key mechanism underlying this disorder. The present study aimed to clarify the long-term influence of early poverty on OFC volume and its association with CD symptoms in healthy participants of an epidemiological cohort study followed since birth. At age 25 years, voxel-based morphometry was applied to study brain volume differences. Poverty (0 = non-exposed (N = 134), I = exposed (N = 33)) and smoking during pregnancy were determined using a standardized parent interview, and information on maternal responsiveness was derived from videotaped mother infant interactions at the age of 3 months. CD symptoms were assessed by diagnostic interview from 8 to 19 years of age. Information on life stress was acquired at each assessment and childhood maltreatment was measured using retrospective self-report at the age of 23 years. Analyses were adjusted for sex, parental psychopathology and delinquency, obstetric adversity, parental education, and current poverty. Individuals exposed to early life poverty exhibited a lower OFC volume. Moreover, we replicated previous findings of increased CD symptoms as a consequence of childhood poverty. This effect proved statistically mediated by OFC volume and exposure to life stress and smoking during pregnancy, but not by childhood maltreatment and maternal responsiveness. These findings underline the importance of studying the impact of early life adversity on brain alterations and highlight the need for programs to decrease income-related disparities.
Y1  - 2015
U6  - https://doi.org/10.1038/npp.2014.277
SN  - 0893-133X
SN  - 1740-634X
VL  - 40
IS  - 4
SP  - 996
EP  - 1004
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Huntebrinker, Jan Willem
A1  - Ludwig, Ulrike
A1  - Funke, Nikolas
A1  - Evert, Urte
A1  - Füssel, Marian
A1  - Wolf, Klaus
A1  - Straßburger, Martin
A1  - Braun, Linda
A1  - Sonkajärvi, Hanna
A1  - Winklel, Carmen
A1  - Rogge, Jörg
T1  - Militär und Gesellschaft in der Frühen Neuzeit = Themenheft: Militär und materielle Kultur in der Frühen Neuzeit
N2  - Ansätze der materiellen Kulturforschung mit militärgeschichtlichen Fragestellungen zusammenzuführen erscheint naheliegend – ist doch die Welt des Militärs von Dingen geprägt und sind es doch die überlieferten ‚militärischen Artefakte’, wie Waffen, Rüstungen, Ehrenzeichen und Uniformen, die unsere Vorstellungen vom Militär der Frühen Neuzeit erheblich beeinflussen. Dennoch fehlen bisher Untersuchungen, in denen die Fragestellungen des kulturwissenschaftlichen material turn und der frühneuzeitlichen Militärgeschichte aufeinander bezogen werden weitgehend. Das vorliegende Themenheft versteht sich als ein erster Beitrag, diese Lücke zu schließen. Anhand von Untersuchungen zum Umgang mit Dingen und der Bedeutungszuschreibung an Dinge in der militärischen Lebenswelt werden in den Beiträgen so einerseits die Bedeutungsebenen der materiellen Kultur des Militärs und andererseits die Relevanz der materiellen Kultur für die gesellschaftlichen Wahrnehmungsmodi des Militärs als sozialer Gruppe betrachtet. Auf diese Weise gelingt es, mit den Ansätzen der materiellen Kulturforschung innovative Perspektiven auf das Verhältnis von Militär und Gesellschaft zu entwickeln.
T3  - Militär und Gesellschaft in der frühen Neuzeit - 13, Heft 1 
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30756
SN  - 978-3-940793-93-5
SN  - 1617-9722
SN  - 1861-910X
VL  - 13
IS  - 1
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Steinke, Martin
A1  - Oskinova, Lida
A1  - Hamann, Wolf-Rainer
A1  - Sander, Andreas Alexander Christoph
A1  - Liermann, A.
A1  - Todt, Helge Tobias
T1  - Analysis of the WN star WR102c, its WR nebula, and the associated cluster of massive stars in the Sickle Nebula
JF  - Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth
N2  - Context. The massive Wolf-Rayet type star WR102c is located near the Quintuplet Cluster, one of the three massive star clusters in the Galactic centre region. Previous studies indicated that WR102c may have a dusty circumstellar nebula and is among the main ionising sources of the Sickle Nebula associated with the Quintuplet Cluster. Aims. The goals of our study are to derive the stellar parameters of WR102c from the analysis of its spectrum and to investigate its stellar and nebular environment. Methods. We obtained observations with the ESO VLT integral field spectrograph SINFONI in the K-band, extracted the stellar spectra, and analysed them by means of stellar atmosphere models. Results. Our new analysis supersedes the results previously reported for WR102c. We significantly decrease its bolometric luminosity and hydrogen content. We detect four early OB type stars close to WR102c. These stars have radial velocities similar to that of WR102c. We suggest that together with WR102c these stars belong to a distinct star cluster with a total mass of similar to 1000 M-circle dot. We identify a new WR nebula around WR102c in the SINFONI map of the di ff use Br gamma emission and in the HST Pa ff images. The Br gamma line at di ff erent locations is not significantly broadened and similar to the width of nebular emission elsewhere in the H i i region around WR102c. Conclusions. The massive star WR102c located in the Galactic centre region resides in a star cluster containing additional early-type stars. The stellar parameters of WR102c are typical for hydrogen-free WN6 stars. We identify a nebula surrounding WR102c that has a morphology similar to other nebulae around hydrogen-free WR stars, and propose that the formation of this nebula is linked to interaction of the fast stellar wind with the matter ejected at a previous evolutionary stage of WR102c.
KW  - stars: early-type
KW  - stars: individual: WR 102c
KW  - stars: Wolf
KW  - Rayet
KW  - Galaxy: center
KW  - HII regions
KW  - infrared: stars
Y1  - 2016
U6  - https://doi.org/10.1051/0004-6361/201527692
SN  - 1432-0746
VL  - 588
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Tong, Yujin
A1  - Wirth, Jonas
A1  - Kirsch, Harald
A1  - Wolf, Martin
A1  - Saalfrank, Peter
A1  - Campen, Richard Kramer
T1  - Optically probing Al-O and O-H vibrations to characterize water adsorption and surface reconstruction on alpha-alumina: An experimental and theoretical study
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr
N2  - Oxide/water interfaces are ubiquitous in a wide variety of applications and the environment. Despite this ubiquity, and attendant decades of study, gaining molecular level insight into water/oxide interaction has proven challenging. In part, this challenge springs from a lack of tools to concurrently characterize changes in surface structure (i.e., water/oxide interaction from the perspective of the solid) and O-H population and local environment (i.e., water/oxide interaction from the water perspective). Here, we demonstrate the application of surface specific vibrational spectroscopy to the characterization of the interaction of the paradigmatic alpha-Al2O3(0001) surface and water. By probing both the interfacial Al-O (surface phonon) and O-H spectral response, we characterize this interaction from both perspectives. Through electronic structure calculation, we assign the interfacial Al-O response and rationalize its changes on surface dehydroxylation and reconstruction. Because our technique is all-optical and interface specific, it is equally applicable to oxide surfaces in vacuum, ambient atmospheres and at the solid/liquid interface. Application of this approach to additional alumina surfaces and other oxides thus seems likely to significantly expand our understanding of how water meets oxide surfaces and thus the wide variety of phenomena this interaction controls. (C) 2015 AIP Publishing LLC.
Y1  - 2015
U6  - https://doi.org/10.1063/1.4906346
SN  - 0021-9606
SN  - 1089-7690
VL  - 142
IS  - 5
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Kirsch, Harald
A1  - Wirth, Jonas
A1  - Tong, Yujin
A1  - Wolf, Martin
A1  - Saalfrank, Peter
A1  - Campen, Richard Kramer
T1  - Experimental characterization of unimolecular water dissociative adsorption on alpha-alumina
JF  - The journal of physical chemistry : C, Nanomaterials and interfaces
N2  - alpha-Al2O3 surfaces are common in both engineered applications and the environment. Much prior work indicates that their properties, e.g., reactivity, polarity, and charge, change dramatically on interaction with water. Perhaps the simplest question that can be asked of alpha-Al2O3/water interaction is how a single water molecule interacts with the most stable alpha-Al2O3 surface: the alpha-Al2O3(0001). Over the last 15 years, a series of theoretical studies have found that water dissociatively adsorbs on alpha-Al2O3(0001) through two channels. However, to our knowledge no experimental evidence of these dissociation pathways has appeared. By combining sample preparation via supersonic molecular beam dosing, sample characterization via coherent, surface specific vibrational spectroscopy and electronic structure theory, we report the first experimental observation of reaction products of each, theoretically predicted, dissociation channel. These results thus overcome a 15 year old experiment/theory disconnect and make possible a variety of intriguing experiments that promise to provide significant new insights into water/Al2O3 and water/oxide interaction more generally.
Y1  - 2014
U6  - https://doi.org/10.1021/jp502106t
SN  - 1932-7447
VL  - 118
IS  - 25
SP  - 13623
EP  - 13630
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - GEN
A1  - Guerrero, Martín A.
A1  - Chu, You-Hua
A1  - Hamann, Wolf-Rainer
A1  - Oskinova, Lida
A1  - Schönberner, Detlef
A1  - Todt, Helge Tobias
A1  - Steffen, Matthias
A1  - Ruiz, Nieves
A1  - Gruendl, Robert A.
A1  - Blair, William P.
T1  - Ablation and wind mass-loading in the born-again planetary nebula A 30
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - We present XMM-Newton and Chandra observations of the born-again planetary nebula A 30. These X-ray observations reveal a bright unresolved source at the position of the central star whose X-ray luminosity exceeds by far the model expectations for photospheric emission and for shocks within the stellar wind. We suggest that a “born-again hot bubble” may be responsible for this X-ray emission. Diffuse X-ray emission associated with the petal-like features and one of the H-poor knots seen in the optical is also found. The weakened emission of carbon lines in the spectrum of the diffuse emission can be interpreted as the dilution of stellar wind by mass-loading or as the detection of material ejected during a very late thermal pulse.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 563 
KW  - planetary nebulae: individual (A 30)
KW  - X-rays: ISM
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-412341
SN  - 1866-8372
IS  - 563
ER  - 
TY  - JOUR
A1  - Guerrero, Martín A.
A1  - Ruiz, N.
A1  - Hamann, Wolf-Rainer
A1  - Chu, Y.-H.
A1  - Todt, Helge Tobias
A1  - Schönberner, Detlef
A1  - Oskinova, Lida
A1  - Gründl, R. A.
A1  - Steffen, M.
A1  - Blair, William P.
A1  - Toala, Jesús Alberto
T1  - Rebirth of X-Ray emission from the born-again planetary Nebula A30
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - The planetary nebula A30 is believed to have undergone a very late thermal pulse resulting in the ejection of knots of hydrogen-poor material. Using multi-epoch Hubble Space Telescope images, we have detected the angular expansion of these knots and derived an age of 850(-150)(+280) yr. To investigate the spectral and spatial properties of the soft X-ray emission detected by ROSAT, we have obtained Chandra and XMM-Newton deep observations of A30. The X-ray emission from A30 can be separated into two components: a point source at the central star and diffuse emission associated with the hydrogen-poor knots and the cloverleaf structure inside the nebular shell. To help us assess the role of the current stellar wind in powering this X-ray emission, we have determined the stellar parameters and wind properties of the central star of A30 using a non-LTE model fit to its optical and UV spectra. The spatial distribution and spectral properties of the diffuse X-ray emission are highly suggestive that it is generated by the post-born-again and present fast stellar winds interacting with the hydrogen-poor ejecta of the born-again event. This emission can be attributed to shock-heated plasma, as the hydrogen-poor knots are ablated by the stellar winds, under which circumstances the efficient mass loading of the present fast stellar wind raises its density and damps its velocity to produce the observed diffuse soft X-rays. Charge transfer reactions between the ions of the stellar winds and material of the born-again ejecta have also been considered as a possible mechanism for the production of diffuse X-ray emission, and upper limits on the expected X-ray production by this mechanism have been derived. The origin of the X-ray emission from the central star of A30 is puzzling: shocks in the present fast stellar wind and photospheric emission can be ruled out, while the development of a new, compact hot bubble confining the fast stellar wind seems implausible.
KW  - planetary nebulae: general
KW  - planetary nebulae: individual (A30)
KW  - stars: winds, outflows
KW  - X-rays: ISM
Y1  - 2012
U6  - https://doi.org/10.1088/0004-637X/755/2/129
SN  - 0004-637X
VL  - 755
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Fang, X.
A1  - Guerrero, Martín A.
A1  - Marquez-Lugo, R. A.
A1  - Toala, Jesús Alberto
A1  - Arthur, S. J.
A1  - Chu, Y.-H.
A1  - Blair, William P.
A1  - Gruendl, R. A.
A1  - Hamann, Wolf-Rainer
A1  - Oskinova, Lida
A1  - Todt, Helge Tobias
T1  - Expansion of hydrogen-poor knots in the born-again planetary nebulae A30 and A78
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We analyze the expansion of hydrogen-poor knots and filaments in the born-again planetary nebulae A30 and A78 based on Hubble Space Telescope ( HST) images obtained almost 20 yr apart. The proper motion of these features generally increases with distance to the central star, but the fractional expansion decreases, i.e., the expansion is not homologous. As a result, there is not a unique expansion age, which is estimated to be 610-950 yr for A30 and 600-1140 yr for A78. The knots and filaments have experienced complex dynamical processes: the current fast stellar wind is mass loaded by the material ablated from the inner knots; the ablated material is then swept up until it shocks the inner edges of the outer, hydrogen-rich nebula. The angular expansion of the outer filaments shows a clear dependence on position angle, indicating that the interaction of the stellar wind with the innermost knots channels the wind along preferred directions. The apparent angular expansion of the innermost knots seems to be dominated by the rocket effect of evaporating gas and by the propagation of the ionization front inside them. Radiation-hydrodynamical simulations show that a single ejection of material followed by a rapid onset of the stellar wind and ionizing flux can reproduce the variety of clumps and filaments at different distances from the central star found in A30 and A78.
KW  - ISM: kinematics and dynamics
KW  - planetary nebulae: individual (A30 and A78)
Y1  - 2014
U6  - https://doi.org/10.1088/0004-637X/797/2/100
SN  - 0004-637X
SN  - 1538-4357
VL  - 797
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Toala, Jesús Alberto
A1  - Guerrero, Martín A.
A1  - Todt, Helge Tobias
A1  - Hamann, Wolf-Rainer
A1  - Chu, Y.-H.
A1  - Gruendl, R. A.
A1  - Schönberner, Detlef
A1  - Oskinova, Lida
A1  - Marquez-Lugo, R. A.
A1  - Fang, X.
A1  - Ramos-Larios, Gerardo
T1  - The born-again Planetary nebula A78: an X-RAY twin of A30
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present the XMM-Newton discovery of X-ray emission from the planetary nebula (PN) A78, the second born-again PN detected in X-rays apart from A30. These two PNe share similar spectral and morphological characteristics: they harbor diffuse soft X-ray emission associated with the interaction between the H-poor ejecta and the current fast stellar wind and a point-like source at the position of the central star (CSPN). We present the spectral analysis of the CSPN, using for the first time an NLTE code for expanding atmospheres that takes line blanketing into account for the UV and optical spectra. The wind abundances are used for the X-ray spectral analysis of the CSPN and the diffuse emission. The X-ray emission from the CSPN in A78 can be modeled by a single C VI emission line, while the X-ray emission from its diffuse component is better described by an optically thin plasma emission model with a temperature of kT = 0.088 keV (T approximate to 1.0 x 10(6) K). We estimate X-ray luminosities in the 0.2-2.0 keV energy band of L-X,L-CSPN =(1.2 +/- 0.3) x 10(31) erg s(-1) and L-X,L-DIFF =(9.2 +/- 2.3) x 10(30) erg s(-1) for the CSPN and diffuse components, respectively.
KW  - planetary nebulae: general
KW  - planetary nebulae: individual (A78)
KW  - stars: winds, outflows
KW  - X-rays: ISM
Y1  - 2015
U6  - https://doi.org/10.1088/0004-637X/799/1/67
SN  - 0004-637X
SN  - 1538-4357
VL  - 799
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Toala, Jesús Alberto
A1  - Oskinova, Lida
A1  - Hamann, Wolf-Rainer
A1  - Ignace, Richard
A1  - Sander, Andreas Alexander Christoph
A1  - Shenar, Tomer
A1  - Todt, Helge Tobias
A1  - Chu, Y. -H.
A1  - Guerrero, Martin A.
A1  - Hainich, Rainer
A1  - Torrejon, Jose Miguel
T1  - On the Apparent Absence of Wolf-Rayet plus Neutron Star Systems
BT  - the Curious Case of WR124
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters
N2  - Among the different types of massive stars in advanced evolutionary stages is the enigmatic WN8h type. There are only a few Wolf-Rayet (WR) stars with this spectral type in our Galaxy. It has long been suggested that WN8h-type stars are the products of binary evolution that may harbor neutron stars (NS). One of the most intriguing WN8h stars is the runaway WR 124 surrounded by its magnificent nebula M1-67. We test the presence of an accreting NS companion in WR 124 using similar to 100 ks long observations by the Chandra X-ray observatory. The hard X-ray emission from WR 124 with a luminosity of L-X similar to 10(31) erg s(-1) is marginally detected. We use the non-local thermodynamic equilibrium stellar atmosphere code PoWR to estimate the WR wind opacity to the X-rays. The wind of a WN8-type star is effectively opaque for X-rays, hence the low X-ray luminosity of WR 124 does not rule out the presence of an embedded compact object. We suggest that, in general, high-opacity WR winds could prevent X-ray detections of embedded NS, and be an explanation for the apparent lack of WR+NS systems.
KW  - circumstellar matter
KW  - ISM: jets and outflows
KW  - stars: massive
KW  - stars: evolution
KW  - stars: neutron
KW  - stars: Wolf-Rayet
Y1  - 2018
U6  - https://doi.org/10.3847/2041-8213/aaf39d
SN  - 2041-8205
SN  - 2041-8213
VL  - 869
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Kamjunke, Norbert
A1  - Beckers, Liza-Marie
A1  - Herzsprung, Peter
A1  - von Tümpling, Wolf
A1  - Lechtenfeld, Oliver
A1  - Tittel, Jörg
A1  - Risse-Buhl, Ute
A1  - Rode, Michael
A1  - Wachholz, Alexander
A1  - Kallies, Rene
A1  - Schulze, Tobias
A1  - Krauss, Martin
A1  - Brack, Werner
A1  - Comero, Sara
A1  - Gawlik, Bernd Manfred
A1  - Skejo, Hello
A1  - Tavazzi, Simona
A1  - Mariani, Giulio
A1  - Borchardt, Dietrich
A1  - Weitere, Markus
T1  - Lagrangian profiles of riverine autotrophy, organic matter transformation, and micropollutants at extreme drought
JF  - The science of the total environment : an international journal for scientific research into the environment and its relationship with man
N2  - On their way from inland to the ocean, flowing water bodies, their constituents and their biotic communities are ex-posed to complex transport and transformation processes. However, detailed process knowledge as revealed by La-grangian measurements adjusted to travel time is rare in large rivers, in particular at hydrological extremes. To fill this gap, we investigated autotrophic processes, heterotrophic carbon utilization, and micropollutant concentrations applying a Lagrangian sampling design in a 600 km section of the River Elbe (Germany) at historically low discharge. Under base flow conditions, we expect the maximum intensity of instream processes and of point source impacts. Phy-toplankton biomass and photosynthesis increased from upstream to downstream sites but maximum chlorophyll con-centration was lower than at mean discharge. Concentrations of dissolved macronutrients decreased to almost complete phosphate depletion and low nitrate values. The longitudinal increase of bacterial abundance and production was less pronounced than in wetter years and bacterial community composition changed downstream. Molecular analyses revealed a longitudinal increase of many DOM components due to microbial production, whereas saturated lipid-like DOM, unsaturated aromatics and polyphenols, and some CHOS surfactants declined. In decomposition exper-iments, DOM components with high O/C ratios and high masses decreased whereas those with low O/C ratios, low masses, and high nitrogen content increased at all sites. Radiocarbon age analyses showed that DOC was relatively old (890-1870 years B.P.), whereas the mineralized fraction was much younger suggesting predominant oxidation of algal lysis products and exudates particularly at downstream sites. Micropollutants determining toxicity for algae (terbuthylazine, terbutryn, isoproturon and lenacil), hexachlorocyclohexanes and DDTs showed higher concentrations from the middle towards the downstream part but calculated toxicity was not negatively correlated to phytoplankton. Overall, autotrophic and heterotrophic process rates and micropollutant concentrations increased from up-to down-stream reaches, but their magnitudes were not distinctly different to conditions at medium discharges.
KW  - Phytoplankton
KW  - Nutrients
KW  - Dissolved organic matter (DOM)
KW  - bacteria
KW  - Respiration
KW  - Micropollutants
Y1  - 2022
U6  - https://doi.org/10.1016/j.scitotenv.2022.154243
SN  - 0048-9697
SN  - 1879-1026
VL  - 828
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dell'Angela, M.
A1  - Anniyev, Toyli
A1  - Beye, Martin
A1  - Coffee, Ryan
A1  - Föhlisch, Alexander
A1  - Gladh, J.
A1  - Katayama, T.
A1  - Kaya, S.
A1  - Krupin, O.
A1  - LaRue, J.
A1  - Mogelhoj, A.
A1  - Nordlund, D.
A1  - Norskov, J. K.
A1  - Oberg, H.
A1  - Ogasawara, H.
A1  - Ostrom, H.
A1  - Pettersson, Lars G. M.
A1  - Schlotter, W. F.
A1  - Sellberg, J. A.
A1  - Sorgenfrei, Nomi
A1  - Turner, J. J.
A1  - Wolf, M.
A1  - Wurth, W.
A1  - Nilsson, A.
T1  - Real-time observation of surface bond breaking with an X-ray Laser
JF  - Science
N2  - We used the Linac Coherent Light Source free-electron x-ray laser to probe the electronic structure of CO molecules as their chemisorption state on Ru(0001) changes upon exciting the substrate by using a femtosecond optical laser pulse. We observed electronic structure changes that are consistent with a weakening of the CO interaction with the substrate but without notable desorption. A large fraction of the molecules (30%) was trapped in a transient precursor state that would precede desorption. We calculated the free energy of the molecule as a function of the desorption reaction coordinate using density functional theory, including van der Waals interactions. Two distinct adsorption wells-chemisorbed and precursor state separated by an entropy barrier-explain the anomalously high prefactors often observed in desorption of molecules from metals.
Y1  - 2013
U6  - https://doi.org/10.1126/science.1231711
SN  - 0036-8075
VL  - 339
IS  - 6125
SP  - 1302
EP  - 1305
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Beye, Martin
A1  - Anniyev, Toyli
A1  - Coffee, Ryan
A1  - Dell'Angela, Martina
A1  - Föhlisch, Alexander
A1  - Gladh, J.
A1  - Katayama, T.
A1  - Kaya, S.
A1  - Krupin, O.
A1  - Mogelhoj, A.
A1  - Nilsson, A.
A1  - Nordlund, D.
A1  - Norskov, J. K.
A1  - Oberg, H.
A1  - Ogasawara, H.
A1  - Pettersson, Lars G. M.
A1  - Schlotter, W. F.
A1  - Sellberg, J. A.
A1  - Sorgenfrei, Nomi
A1  - Turner, J. J.
A1  - Wolf, M.
A1  - Wurth, Wilfried
A1  - Ostrom, H.
T1  - Selective ultrafast probing of transient hot chemisorbed and precursor States of CO on Ru(0001)
JF  - Physical review letters
N2  - We have studied the femtosecond dynamics following optical laser excitation of CO adsorbed on a Ru surface by monitoring changes in the occupied and unoccupied electronic structure using ultrafast soft x-ray absorption and emission. We recently reported [M. Dell'Angela et al. Science 339, 1302 (2013)] a phonon-mediated transition into a weakly adsorbed precursor state occurring on a time scale of >2 ps prior to desorption. Here we focus on processes within the first picosecond after laser excitation and show that the metal-adsorbate coordination is initially increased due to hot-electron-driven vibrational excitations. This process is faster than, but occurs in parallel with, the transition into the precursor state. With resonant x-ray emission spectroscopy, we probe each of these states selectively and determine the respective transient populations depending on optical laser fluence. Ab initio molecular dynamics simulations of CO adsorbed on Ru(0001) were performed at 1500 and 3000 K providing insight into the desorption process.
Y1  - 2013
U6  - https://doi.org/10.1103/PhysRevLett.110.186101
SN  - 0031-9007
VL  - 110
IS  - 18
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - GEN
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
T2  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
T3  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379
IS  - 19
ER  - 
TY  - BOOK
A1  - Adriano, Christian
A1  - Bleifuß, Tobias
A1  - Cheng, Lung-Pan
A1  - Diba, Kiarash
A1  - Fricke, Andreas
A1  - Grapentin, Andreas
A1  - Jiang, Lan
A1  - Kovacs, Robert
A1  - Krejca, Martin Stefan
A1  - Mandal, Sankalita
A1  - Marwecki, Sebastian
A1  - Matthies, Christoph
A1  - Mattis, Toni
A1  - Niephaus, Fabio
A1  - Pirl, Lukas
A1  - Quinzan, Francesco
A1  - Ramson, Stefan
A1  - Rezaei, Mina
A1  - Risch, Julian
A1  - Rothenberger, Ralf
A1  - Roumen, Thijs
A1  - Stojanovic, Vladeta
A1  - Wolf, Johannes
ED  - Meinel, Christoph
ED  - Plattner, Hasso
ED  - Döllner, Jürgen Roland Friedrich
ED  - Weske, Mathias
ED  - Polze, Andreas
ED  - Hirschfeld, Robert
ED  - Naumann, Felix
ED  - Giese, Holger
ED  - Baudisch, Patrick
ED  - Friedrich, Tobias
ED  - Böttinger, Erwin
ED  - Lippert, Christoph
T1  - Technical report
BT  - Fall Retreat 2018
N2  - Design and Implementation of service-oriented architectures imposes a huge number of research questions from the fields of software engineering, system analysis and modeling, adaptability, and application integration. Component orientation and web services are two approaches for design and realization of complex web-based system. Both approaches allow for dynamic application adaptation as well as integration of enterprise application.

Commonly used technologies, such as J2EE and .NET, form de facto standards for the realization of complex distributed systems. Evolution of component systems has lead to web services and service-based architectures. This has been manifested in a multitude of industry standards and initiatives such as XML, WSDL UDDI, SOAP, etc. All these achievements lead to a new and promising paradigm in IT systems engineering which proposes to design complex software solutions as collaboration of contractually defined software services.

Service-Oriented Systems Engineering represents a symbiosis of best practices in object-orientation, component-based development, distributed computing, and business process management. It provides integration of business and IT concerns.

The annual Ph.D. Retreat of the Research School provides each member the opportunity to present his/her current state of their research and to give an outline of a prospective Ph.D. thesis. Due to the interdisciplinary structure of the research school, this technical report covers a wide range of topics. These include but are not limited to: Human Computer Interaction and Computer Vision as Service; Service-oriented Geovisualization Systems; Algorithm Engineering for Service-oriented Systems; Modeling and Verification of Self-adaptive Service-oriented Systems; Tools and Methods for Software Engineering in Service-oriented Systems; Security Engineering of Service-based IT Systems; Service-oriented Information Systems; Evolutionary Transition of Enterprise Applications to Service Orientation; Operating System Abstractions for Service-oriented Computing; and Services Specification, Composition, and Enactment.
N2  - Der Entwurf und die Realisierung dienstbasierender Architekturen wirft eine Vielzahl von Forschungsfragestellungen aus den Gebieten der Softwaretechnik, der Systemmodellierung und -analyse, sowie der Adaptierbarkeit und Integration von Applikationen auf. Komponentenorientierung und WebServices sind zwei Ansätze für den effizienten Entwurf und die Realisierung komplexer Web-basierender Systeme. Sie ermöglichen die Reaktion auf wechselnde Anforderungen ebenso, wie die Integration großer komplexer Softwaresysteme.

Heute übliche Technologien, wie J2EE und .NET, sind de facto Standards für die Entwicklung großer verteilter Systeme. Die Evolution solcher Komponentensysteme führt über WebServices zu dienstbasierenden Architekturen. Dies manifestiert sich in einer Vielzahl von Industriestandards und Initiativen wie XML, WSDL, UDDI, SOAP. All diese Schritte führen letztlich zu einem neuen, vielversprechenden Paradigma für IT Systeme, nach dem komplexe Softwarelösungen durch die Integration vertraglich vereinbarter Software-Dienste aufgebaut werden sollen.

"Service-Oriented Systems Engineering" repräsentiert die Symbiose bewährter Praktiken aus den Gebieten der Objektorientierung, der Komponentenprogrammierung, des verteilten Rechnen sowie der Geschäftsprozesse und berücksichtigt auch die Integration von Geschäftsanliegen und Informationstechnologien.

Die Klausurtagung des Forschungskollegs "Service-oriented Systems Engineering" findet einmal jährlich statt und bietet allen Kollegiaten die Möglichkeit den Stand ihrer aktuellen Forschung darzulegen. Bedingt durch die Querschnittstruktur des Kollegs deckt dieser Bericht ein weites Spektrum aktueller Forschungsthemen ab. Dazu zählen unter anderem Human Computer Interaction and Computer Vision as Service; Service-oriented Geovisualization Systems; Algorithm Engineering for Service-oriented Systems; Modeling and Verification of Self-adaptive Service-oriented Systems; Tools and Methods for Software Engineering in Service-oriented Systems; Security Engineering of Service-based IT Systems; Service-oriented Information Systems; Evolutionary Transition of Enterprise Applications to Service Orientation; Operating System Abstractions for Service-oriented Computing; sowie Services Specification, Composition, and Enactment.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 129 
KW  - Hasso Plattner Institute
KW  - research school
KW  - Ph.D. retreat
KW  - service-oriented systems engineering
KW  - Hasso-Plattner-Institut
KW  - Forschungskolleg
KW  - Klausurtagung
KW  - Service-oriented Systems Engineering
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427535
SN  - 978-3-86956-465-4
SN  - 1613-5652
SN  - 2191-1665
IS  - 129
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
JF  - Kidney international : official journal of the International Society of Nephrology
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - https://doi.org/10.1016/j.kint.2020.09.030
SN  - 0085-2538
SN  - 1523-1755
VL  - 99
IS  - 4
SP  - 926
EP  - 939
PB  - Elsevier
CY  - New York
ER  -