TY  - JOUR
A1  - Hermanussen, Michael
A1  - Pulungan, Aman B.
A1  - Scheffler, Christiane
A1  - Mumm, Rebekka
A1  - Rogol, Alan D.
A1  - Pop, Raluca
A1  - Swanson, James M.
A1  - Sonuga-Barke, Edmund
A1  - Reimann, Anna
A1  - Siniarska-Wolanska, Anna
A1  - Musalek, Martin
A1  - Bogin, Barry
A1  - Boldsen, Jesper L.
A1  - Tassenaar, (Vincent)
A1  - Groth, Detlef
A1  - Liu, Yuk-Chien
A1  - Meigen, Christof
A1  - Quanjer, Bjorn
A1  - Thompson, Kristina
A1  - Ozer, Baak Koca
A1  - Bryl, Ewa
A1  - Mamrot, Paula
A1  - Hanc, Tomasz
A1  - Koziel, Slawomir
A1  - Soderhall, Jani
A1  - Gomula, Aleksandra
A1  - Banik, Sudip Datta
A1  - Roelants, Mathieu
A1  - Veldre, Gudrun
A1  - Lieberman, Leslie Sue
A1  - Sievert, Lynnette Leidy
T1  - Meeting Reports
BT  - The Role of Beliefs and Perception on Body Size. Proceedings of the 26th Aschauer Soiree, Held at Aschauhof, Altenhof, Germany, May 26th, 2018
JF  - Pediatric Endocrinology Reviews
N2  - Thirty-one scientists met at Aschauhof, Germany to discuss the role of beliefs and self-perception on body size. In view of apparent growth stimulatory effects of dominance within the social group that is observed in social mammals, they discussed various aspects of competitive growth strategies and growth adjustments. Presentations included new data from Indonesia, a cohort-based prospective study from Merida, Yucatan, and evidence from recent meta-analyses and patterns of growth in the socially deprived. The effects of stress experienced during pregnancy and adverse childhood events were discussed, as well as obesity in school children, with emphasis on problems when using z-scores in extremely obese children. Aspects were presented on body image in African-American women, and body perception and the disappointments of menopause in view of feelings of attractiveness in different populations. Secular trends in height were presented, including short views on so called 'racial types' vs bio-plasticity, and historic data on early-life nutritional status and later-life socioeconomic outcomes during the Dutch potato famine. New tools for describing body proportions in patients with variable degrees of phocomelia were presented along with electronic growth charts. Bio-statisticians discussed the influence of randomness, community and network structures, and presented novel tools and methods for analyzing social network data.
KW  - Body size
KW  - Social group
KW  - Social network
KW  - Body perception
KW  - Competitive growth strategies
KW  - Growth adjustment
Y1  - 2019
U6  - https://doi.org/10.17458/per.vol16.2019.hps.mr.26achauersoiree
SN  - 1565-4753
VL  - 16
IS  - 3
SP  - 383
EP  - 400
PB  - Medical Media
CY  - Netanya
ER  - 
TY  - JOUR
A1  - Tomas, Sara
A1  - Homann, Martin
A1  - Mutti, Maria
A1  - Amour, Frederic
A1  - Christ, Nicolas
A1  - Immenhauser, Adrian
A1  - Agar, Susan M.
A1  - Kabiri, Lahcen
T1  - Alternation of microbial mounds and ooid shoals (Middle Jurasssic, Morocco) - response to paleoenvironmental changes
JF  - Sedimentary geology : international journal of applied and regional sedimentology
N2  - The occurrence of neritic microbial carbonates is often related to ecological refuges, where grazers and other competitors are reduced by environmental conditions, or to post-extinction events (e.g. in the Late Devonian, Early Triassic). Here, we present evidence for Middle Jurassic (Bajocian) microbial mounds formed in the normal marine, shallow neritic setting of an inner, ramp system from the High Atlas of Morocco. The microbial mounds are embedded in cross-bedded oolitic facies. Individual mounds show low relief domal geometries (up to 3 m high and 4.5 m across), but occasionally a second generation of mounds exhibits tabular geometries (<1 m high). The domes are circular in plan view and have intact tops, lacking evidence of current influence on mound preferred growth direction or distribution patterns, or truncation. The mound fades consists almost entirely of non-laminated, micritic thrombolites with branching morphologies and fine-grained, clotted and peloidal fabrics. Normal marine biota are present but infrequent. Several lines of evidence document that microbial mound growth alternates with time intervals of active ooid shoal deposition. This notion is of general significance when compared with modern Bahamian microbialites that co-exist with active sub-aquatic dunes. Furthermore, the lack of detailed studies of Middle Jurassic, normal marine shallow neritic microbial mounds adds a strong motivation for the present study. Specifically, Bajocian mounds formed on a firmground substratum during transgressive phases under condensed sedimentation. Furthermore, a transient increase in nutrient supply in the prevailing mesotrophic setting, as suggested by the heterotrophic-dominated biota, may have controlled microbial mound stages.
KW  - Microbial mounds
KW  - Thrombolites
KW  - Ooid shoals
KW  - Paleoenvironment
KW  - Jurassic
Y1  - 2013
U6  - https://doi.org/10.1016/j.sedgeo.2013.05.008
SN  - 0037-0738
VL  - 294
SP  - 68
EP  - 82
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilke, Franziska Daniela Helena
A1  - O'Brien, Patrick J.
A1  - Gerdes, Axel
A1  - Timmerman, Martin Jan
A1  - Sudo, Masafumi
A1  - Khan, M. Ahmed
T1  - The multistage exhumation history of the Kaghan Valley UHP series, NW Himalaya, Pakistan from U-Pb and Ar-40/Ar- 39 ages
N2  - Amphibole and mica Ar-40/Ar-39 ages as well as zircon, rutile and titanite U-Pb geochronology of eclogites and associated host rocks from the Higher Himalayan Crystalline Nappes (Indian Plate) in the Upper Kaghan Valley, Pakistan allow distinction of a multistage exhumation history. An Eocene age for peak-pressure metamorphism has been obtained by phengite Ar-40/Ar-39 (47.3 +/- 0.3 Ma) and zircon U-Pb (47.3 +/- 0.4 and 47.4 +/- 0.3 Ma) ages from cover and basement gneisses. A very short-lived metamorphic peak and rapid cooling is documented by an amphibole Ar-40/Ar-39 age of 46.6 +/- 0.5 Ma and a rutile U-Pb age of 44.1 +/- 1.3 Ma from eclogites. Phengite and biotite ages from cover and basement sequences metamorphosed during the Himalayan orogeny are 34.5 +/- 0.2 to 28.1 +/- 0.2 Ma whereas youngest biotites, yielding 23.6 +/- 0.1 and 21.7 +/- 0.2 Ma, probably reflect argon partial resetting. The amphibole age, together with those derived from phengite and zircon demonstrate a rate of initial exhumation of 86-143 mm/a i.e. an extremely rapid transport of the Indian Plate continental crust from ultra-high pressure (UHP) conditions back to crustal levels (47-46 Ma for transport from 140 to 40 km depth). Subsequent exhumation (46-41 Ma, 40-35 km) slowed to about 1 mm/a at the base of the continental crust but increased again later towards slightly higher exhumation rates of ca. 2 mm/a (41-34 Ma, 35- 20 km). This indicates a change from buoyancy-driven exhumation at mantle depths to compression forces related to continent-continent collision and accompanied crustal folding, thrusting and stacking that finally exposed the former deeply-buried rocks.
Y1  - 2010
UR  - http://eurjmin.geoscienceworld.org/
U6  - https://doi.org/10.1127/0935-1221/2010/0022-2051
SN  - 0935-1221
ER  - 
TY  - JOUR
A1  - Alonso, Ricardo N.
A1  - Bookhagen, Bodo
A1  - Carrapa, Barbara
A1  - Coutand, Isabelle
A1  - Haschke, Michael
A1  - Hilley, George E.
A1  - Schoenbohm, Lindsay M.
A1  - Sobel, Edward
A1  - Strecker, Manfred
A1  - Trauth, Martin H.
A1  - Villanueva, Arturo
T1  - Tectonics, climate and landscape evolution of the Southern Central Andes : the Argentine Puna Plateau and adjacent regions between 22 and 30°S
Y1  - 2006
SN  - 978-3-540- 24329-8
ER  - 
TY  - JOUR
A1  - Grimm, Volker
A1  - Augusiak, Jacqueline
A1  - Focks, Andreas
A1  - Frank, Beatrice M.
A1  - Gabsi, Faten
A1  - Johnston, Alice S. A.
A1  - Liu, Chun
A1  - Martin, Benjamin T.
A1  - Meli, Mattia
A1  - Radchuk, Viktoriia
A1  - Thorbek, Pernille
A1  - Railsback, Steven Floyd
T1  - Towards better modelling and decision support: Documenting model development, testing, and analysis using TRACE
JF  - Ecological modelling : international journal on ecological modelling and engineering and systems ecolog
N2  - The potential of ecological models for supporting environmental decision making is increasingly acknowledged. However, it often remains unclear whether a model is realistic and reliable enough. Good practice for developing and testing ecological models has not yet been established. Therefore, TRACE, a general framework for documenting a model's rationale, design, and testing was recently suggested. Originally TRACE was aimed at documenting good modelling practice. However, the word 'documentation' does not convey TRACE's urgency. Therefore, we re-define TRACE as a tool for planning, performing, and documenting good modelling practice. TRACE documents should provide convincing evidence that a model was thoughtfully designed, correctly implemented, thoroughly tested, well understood, and appropriately used for its intended purpose. TRACE documents link the science underlying a model to its application, thereby also linking modellers and model users, for example stakeholders, decision makers, and developers of policies. We report on first experiences in producing TRACE documents. We found that the original idea underlying TRACE was valid, but to make its use more coherent and efficient, an update of its structure and more specific guidance for its use are needed. The updated TRACE format follows the recently developed framework of model 'evaludation': the entire process of establishing model quality and credibility throughout all stages of model development, analysis, and application. TRACE thus becomes a tool for planning, documenting, and assessing model evaludation, which includes understanding the rationale behind a model and its envisaged use. We introduce the new structure and revised terminology of TRACE and provide examples. (C) 2014 Elsevier B.V. All rights reserved.
KW  - Standardization
KW  - Good modelling practice
KW  - Risk assessment
KW  - Decision support
Y1  - 2014
U6  - https://doi.org/10.1016/j.ecolmodel.2014.01.018
SN  - 0304-3800
SN  - 1872-7026
VL  - 280
SP  - 129
EP  - 139
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Knie, Christopher
A1  - Utecht, Manuel Martin
A1  - Zhao, Fangli
A1  - Kulla, Hannes
A1  - Kovalenko, Sergey
A1  - Brouwer, Albert M.
A1  - Saalfrank, Peter
A1  - Hecht, Stefan
A1  - Bleger, David
T1  - ortho-Fluoroazobenzenes: visible light switches with very long-lived Z isomers
JF  - Chemistry - a European journal
N2  - Improving the photochemical properties of molecular photoswitches is crucial for the development of light-responsive systems in materials and life sciences. ortho-Fluoroazobenzenes are a new class of rationally designed photochromic azo compounds with optimized properties, such as the ability to isomerize with visible light only, high photoconversions, and unprecedented robust bistable character. Introducing sigma-electron-withdrawing F atoms ortho to the N=N unit leads to both an effective separation of the n -> pi* bands of the E and Z isomers, thus offering the possibility of using these two transitions for selectively inducing E/Z iso-merizations, and greatly enhanced thermal stability of the Z isomers. Additional para-electron-withdrawing groups (EWGs) work in concert with ortho-F atoms, giving rise to enhanced separation of the n -> pi* transitions. A comprehensive study of the effect of substitution on the key photochemical properties of ortho-fluoroazobenzenes is reported herein. In particular, the position, number, and nature of the EWGs have been varied, and the visible light photoconversions, quantum yields of isomerization, and thermal stabilities have been measured and rationalized by DFT calculations.
KW  - azobenzenes
KW  - photochromism
KW  - photoswitches
KW  - substituent effects
KW  - visible light
Y1  - 2014
U6  - https://doi.org/10.1002/chem.201404649
SN  - 0947-6539
SN  - 1521-3765
VL  - 20
IS  - 50
SP  - 16492
EP  - 16501
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Foerster, Verena
A1  - Deocampo, Daniel M.
A1  - Asrat, Asfawossen
A1  - Günter, Christina
A1  - Junginger, Annett
A1  - Krämer, Kai Hauke
A1  - Stroncik, Nicole A.
A1  - Trauth, Martin H.
T1  - Towards an understanding of climate proxy formation in the Chew Bahir basin, southern Ethiopian Rift
JF  - Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences
N2  - Deciphering paleoclimate from lake sediments is a challenge due to the complex relationship between climate parameters and sediment composition. Here we show the links between potassium (K) concentrations in the sediments of the Chew Bahir basin in the Southern Ethiopian Rift and fluctuations in the catchment precipitation/evaporation balance. Our micro-X-ray fluorescence and X-ray diffraction results suggest that the most likely process linking climate with potassium concentrations is the authigenic illitization of smectites during episodes of higher alkalinity and salinity in the closed -basin lake, due to a drier climate. Whole-rock and clay size fraction analyses suggest that illitization of the Chew Bahir clay minerals with increasing evaporation is enhanced by octahedral Al-to-Mg substitution in the clay minerals, with the resulting layer charge increase facilitating potassium-fixation. Linking mineralogy with geochemistry shows the links between hydroclimatic control, process and formation of the Chew Bahir K patterns, in the context of well-known and widely documented eastern African climate fluctuations over the last 45,000 years. These results indicate characteristic mineral alteration patterns associated with orbitally controlled wet-dry cycles such as the African Humid Period (similar to 15-5 ka) or high-latitude controlled climate events such as the Younger Dryas (similar to 12.8-11.6 ka) chronozone. Determining the impact of authigenic mineral alteration on the Chew Bahir records enables the interpretation of the previously established pXRF-derived aridity proxy K and provides a better paleohydrological understanding of complex climate proxy formation.
KW  - Paleoclimatology
KW  - Authigenic mineral transformation
KW  - Potassium
KW  - Illitization
KW  - Zeolites
Y1  - 2018
U6  - https://doi.org/10.1016/j.palaeo.2018.04.009
SN  - 0031-0182
SN  - 1872-616X
VL  - 501
SP  - 111
EP  - 123
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wienhold, Sandra-Maria
A1  - Macri, Mario
A1  - Nouailles, Geraldine
A1  - Dietert, Kristina
A1  - Gurtner, Corinne
A1  - Gruber, Achim D.
A1  - Heimesaat, Markus M.
A1  - Lienau, Jasmin
A1  - Schumacher, Fabian
A1  - Kleuser, Burkhard
A1  - Opitz, Bastian
A1  - Suttorp, Norbert
A1  - Witzenrath, Martin
A1  - Müller-Redetzky, Holger C.
T1  - Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice
JF  - Critical Care
N2  - BackgroundAntibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation, which may induce local and systemic inflammatory responses and development of ventilator-induced lung injury (VILI). The aim of this study was to investigate whether disruption of the microbiota by antibiotic therapy prior to mechanical ventilation affects pulmonary inflammatory responses and thereby the development of VILI.MethodsMice underwent 6-8weeks of enteral antibiotic combination treatment until absence of cultivable bacteria in fecal samples was confirmed. Control mice were housed equally throughout this period. VILI was induced 3 days after completing the antibiotic treatment protocol, by high tidal volume (HTV) ventilation (34ml/kg; positive end-expiratory pressure=2 cmH(2)O) for 4h. Differences in lung function, oxygenation index, pulmonary vascular leakage, macroscopic assessment of lung injury, and leukocyte and lymphocyte differentiation were assessed. Control groups of mice ventilated with low tidal volume and non-ventilated mice were analyzed accordingly.ResultsAntibiotic-induced microbiota depletion prior to HTV ventilation led to aggravation of VILI, as shown by increased pulmonary permeability, increased oxygenation index, decreased pulmonary compliance, enhanced macroscopic lung injury, and increased cytokine/chemokine levels in lung homogenates.ConclusionsDepletion of the microbiota by broad-spectrum antibiotics prior to HTV ventilation renders mice more susceptible to developing VILI, which could be clinically relevant for critically ill patients frequently receiving broad-spectrum antibiotics.
KW  - Broad-spectrum antibiotic therapy
KW  - Ventilator-induced lung injury
KW  - Microbiota
Y1  - 2018
U6  - https://doi.org/10.1186/s13054-018-2213-8
SN  - 1466-609X
SN  - 1364-8535
VL  - 22
IS  - 282
PB  - BMC
CY  - London
ER  - 
TY  - JOUR
A1  - Sellberg, Jonas A.
A1  - McQueen, Trevor A.
A1  - Laksmono, Hartawan
A1  - Schreck, Simon
A1  - Beye, Martin
A1  - DePonte, Daniel P.
A1  - Kennedy, Brian
A1  - Nordlund, Dennis
A1  - Sierra, Raymond G.
A1  - Schlesinger, Daniel
A1  - Tokushima, Takashi
A1  - Zhovtobriukh, Iurii
A1  - Eckert, Sebastian
A1  - Segtnan, Vegard H.
A1  - Ogasawara, Hirohito
A1  - Kubicek, Katharina
A1  - Techert, Simone
A1  - Bergmann, Uwe
A1  - Dakovski, Georgi L.
A1  - Schlotter, William F.
A1  - Harada, Yoshihisa
A1  - Bogan, Michael J.
A1  - Wernet, Philippe
A1  - Föhlisch, Alexander
A1  - Pettersson, Lars G. M.
A1  - Nilsson, Anders
T1  - X-ray emission spectroscopy of bulk liquid water in "no-man's land"
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr
N2  - The structure of bulk liquid water was recently probed by x-ray scattering below the temperature limit of homogeneous nucleation (T-H) of similar to 232 K [J. A. Sellberg et al., Nature 510, 381-384 (2014)]. Here, we utilize a similar approach to study the structure of bulk liquid water below T-H using oxygen K-edge x-ray emission spectroscopy (XES). Based on previous XES experiments [T. Tokushima et al., Chem. Phys. Lett. 460, 387-400 (2008)] at higher temperatures, we expected the ratio of the 1b(1)' and 1b(1)" peaks associated with the lone-pair orbital in water to change strongly upon deep supercooling as the coordination of the hydrogen (H-) bonds becomes tetrahedral. In contrast, we observed only minor changes in the lone-pair spectral region, challenging an interpretation in terms of two interconverting species. A number of alternative hypotheses to explain the results are put forward and discussed. Although the spectra can be explained by various contributions from these hypotheses, we here emphasize the interpretation that the line shape of each component changes dramatically when approaching lower temperatures, where, in particular, the peak assigned to the proposed disordered component would become more symmetrical as vibrational interference becomes more important. (C) 2015 AIP Publishing LLC.
Y1  - 2015
U6  - https://doi.org/10.1063/1.4905603
SN  - 0021-9606
SN  - 1089-7690
VL  - 142
IS  - 4
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Jay, Raphael M.
A1  - Norell, Jesper
A1  - Eckert, Sebastian
A1  - Hantschmann, Markus
A1  - Beye, Martin
A1  - Kennedy, Brian
A1  - Quevedo, Wilson
A1  - Schlotter, William F.
A1  - Dakovski, Georgi L.
A1  - Minitti, Michael P.
A1  - Hoffmann, Matthias C.
A1  - Mitra, Ankush
A1  - Moeller, Stefan P.
A1  - Nordlund, Dennis
A1  - Zhang, Wenkai
A1  - Liang, Huiyang W.
A1  - Kunnus, Kristian
A1  - Kubicek, Katharina
A1  - Techert, Simone A.
A1  - Lundberg, Marcus
A1  - Wernet, Philippe
A1  - Gaffney, Kelly
A1  - Odelius, Michael
A1  - Föhlisch, Alexander
T1  - Disentangling Transient Charge Density and Metal-Ligand Covalency in Photoexcited Ferricyanide with Femtosecond Resonant Inelastic Soft X-ray Scattering
JF  - The journal of physical chemistry letters
N2  - Soft X-ray spectroscopies are ideal probes of the local valence electronic structure of photocatalytically active metal sites. Here, we apply the selectivity of time resolved resonant inelastic X-ray scattering at the iron L-edge to the transient charge distribution of an optically excited charge-transfer state in aqueous ferricyanide. Through comparison to steady-state spectra and quantum chemical calculations, the coupled effects of valence-shell closing and ligand-hole creation are experimentally and theoretically disentangled and described in terms of orbital occupancy, metal-ligand covalency, and ligand field splitting, thereby extending established steady-state concepts to the excited-state domain. pi-Back-donation is found to be mainly determined by the metal site occupation, whereas the ligand hole instead influences sigma-donation. Our results demonstrate how ultrafast resonant inelastic X-ray scattering can help characterize local charge distributions around catalytic metal centers in short-lived charge-transfer excited states, as a step toward future rationalization and tailoring of photocatalytic capabilities of transition-metal complexes.
Y1  - 2018
U6  - https://doi.org/10.1021/acs.jpclett.8b01429
SN  - 1948-7185
VL  - 9
IS  - 12
SP  - 3538
EP  - 3543
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Schreck, Simon
A1  - Beye, Martin
A1  - Sellberg, Jonas A.
A1  - McQueen, Trevor
A1  - Laksmono, Hartawan
A1  - Kennedy, Brian
A1  - Eckert, Sebastian
A1  - Schlesinger, Daniel
A1  - Nordlund, Dennis
A1  - Ogasawara, Hirohito
A1  - Sierra, Raymond G.
A1  - Segtnan, Vegard H.
A1  - Kubicek, Katharina
A1  - Schlotter, William F.
A1  - Dakovski, Georgi L.
A1  - Moeller, Stefan P.
A1  - Bergmann, Uwe
A1  - Techert, Simone
A1  - Pettersson, Lars G. M.
A1  - Wernet, Philippe
A1  - Bogan, Michael J.
A1  - Harada, Yoshihisa
A1  - Nilsson, Anders
A1  - Föhlisch, Alexander
T1  - Reabsorption of soft x-ray emission at high x-ray free-electron laserfluences
JF  - Physical review letters
N2  - We report on oxygen K-edge soft x-ray emission spectroscopy from a liquid water jet at the Linac Coherent Light Source. We observe significant changes in the spectral content when tuning over a wide range of incident x-ray fluences. In addition the total emission yield decreases at high fluences. These modifications result from reabsorption of x-ray emission by valence-excited molecules generated by the Auger cascade. Our observations have major implications for future x-ray emission studies at intense x-ray sources. We highlight the importance of the x-ray pulse length with respect to the core-hole lifetime.
Y1  - 2014
U6  - https://doi.org/10.1103/PhysRevLett.113.153002
SN  - 0031-9007
SN  - 1079-7114
VL  - 113
IS  - 15
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Reifarth, Martin
A1  - Bekir, Marek
A1  - Bapolisi, Alain M.
A1  - Titov, Evgenii
A1  - Nusshardt, Fabian
A1  - Nowaczyk, Julius
A1  - Grigoriev, Dmitry
A1  - Sharma, Anjali
A1  - Saalfrank, Peter
A1  - Santer, Svetlana
A1  - Hartlieb, Matthias
A1  - Böker, Alexander
T1  - A dual pH- and light-responsive spiropyrane-based surfactant
BT  - investigations on Its switching behavior and remote control over emulsion stability
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - A cationic surfactant containing a spiropyrane unit is prepared exhibiting a dual-responsive adjustability of its surface-active characteristics. The switching mechanism of the system relies on the reversible conversion of the non-ionic spiropyrane (SP) to a zwitterionic merocyanine (MC) and can be controlled by adjusting the pH value and via light, resulting in a pH-dependent photoactivity: While the compound possesses a pronounced difference in surface activity between both forms under acidic conditions, this behavior is suppressed at a neutral pH level. The underlying switching processes are investigated in detail, and a thermodynamic explanation based on a combination of theoretical and experimental results is provided. This complex stimuli-responsive behavior enables remote-control of colloidal systems. To demonstrate its applicability, the surfactant is utilized for the pH-dependent manipulation of oil-in-water emulsions.
KW  - Dual-Responsiveness
KW  - Manipulation of Emulsion Stability
KW  - Spiropyrane
KW  - Surfactant
KW  - Switchable Surfactants
KW  - pH-Dependent Photoresponsivity
Y1  - 2022
U6  - https://doi.org/10.1002/anie.202114687
SN  - 1433-7851
SN  - 1521-3773
VL  - 61
IS  - 21
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kreuzer, Lucas
A1  - Widmann, Tobias
A1  - Geiger, Christina
A1  - Wang, Peixi
A1  - Vagias, Apostolos N.
A1  - Heger, Julian Eliah
A1  - Haese, Martin
A1  - Hildebrand, Viet
A1  - Laschewsky, André
A1  - Papadakis, Christine M.
A1  - Müller-Buschbaum, Peter
T1  - Salt-dependent phase transition behavior of doubly thermoresponsive poly(sulfobetaine)-based diblock copolymer thin films
JF  - Langmuir : the ACS journal of surfaces and colloids / American Chemical Society
N2  - The water vapor-induced swelling, as well as subsequent phase-transition kinetics, of thin films of a diblock copolymer (DBC) loaded with different amounts of the salt NaBr, is investigated in situ. In dilute aqueous solution, the DBC features an orthogonally thermoresponsive behavior. It consists of a zwitterionic poly(sulfobetaine) block, namely, poly(4-(N-(3'-methacrylamidopropyl)-N, N-dimethylammonio) butane-1-sulfonate) (PSBP), showing an upper critical solution temperature, and a nonionic block, namely, poly(N-isopropylmethacrylamide) (PNIPMAM), exhibiting a lower critical solution temperature. The swelling kinetics in D2O vapor at 15 degrees C and the phase transition kinetics upon heating the swollen film to 60 degrees C and cooling back to 15 degrees C are followed with simultaneous time-of-flight neutron reflectometry and spectral reflectance measurements. These are complemented by Fourier transform infrared spectroscopy. The collapse temperature of PNIPMAM and the swelling temperature of PSBP are found at lower temperatures than in aqueous solution, which is attributed to the high polymer concentration in the thin-film geometry. Upon inclusion of sub-stoichiometric amounts (relative to the monomer units) of NaBr in the films, the water incorporation is significantly increased. This increase is mainly attributed to a salting-in effect on the zwitterionic PSBP block. Whereas the addition of NaBr notably shifts the swelling temperature of PSBP to lower temperatures, the collapse temperature of PNIPMAM remains unaffected by the presence of salt in the films.
Y1  - 2021
U6  - https://doi.org/10.1021/acs.langmuir.1c01342
SN  - 0743-7463
SN  - 1520-5827
VL  - 37
IS  - 30
SP  - 9179
EP  - 9191
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Holz, Nathalie E.
A1  - Boecker-Schlier, Regina
A1  - Buchmann, Arlette F.
A1  - Blomeyer, Dorothea
A1  - Jennen-Steinmetz, Christine
A1  - Baumeister, Sarah
A1  - Plichta, Michael M.
A1  - Cattrell, Anna
A1  - Schumann, Gunter
A1  - Esser, Günter
A1  - Schmidt, Martin
A1  - Buitelaar, Jan
A1  - Meyer-Lindenberg, Andreas
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder
JF  - Frontiers in human neuroscience
N2  - Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2–19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years).

CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.
KW  - childhood adversity
KW  - conduct disorder
KW  - amygdala
KW  - ventral striatum
KW  - fMRI
Y1  - 2016
U6  - https://doi.org/10.1093/scan/nsw120
SN  - 1749-5016
SN  - 1749-5024
VL  - 12
IS  - 2
SP  - 261
EP  - 272
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Perez-Lopez, Raul
A1  - Martin-Velazquez, Saul
A1  - Sanchez-Moral, Sergio
A1  - Patyniak, Magda
A1  - Lopez-Gutierrez, Jose
A1  - Cuezva, Soledad
A1  - Lario, J.
A1  - Silva, P. G.
A1  - Rodriguez-Pascua, M. A.
A1  - Giner-Robles, J. L.
T1  - New insights on speleoseismology: The geothermal gradient and heat flow values in caves for the study of active faults
JF  - Quaternary international : the journal of the International Union for Quaternary Research
N2  - Normally in paleoseismology, the study of the tectonic slip-rate is performed in trenches on the fault scarp, or by the estimation of fault movements from the geomorphic features. In this work, we have carried out a paleoseismic analysis of the Benis Fault, located in southeast Spain, combined with a geothermal analysis inside a deep cave related to the fault (-350 m). Thus, we have estimated the last earthquake magnitude and time of occurrence from evidence of ceiling collapse and displaced carbonate blocks inside a cave, which is developed across the fault. The magnitude was obtained from the application of the empirical relationship of the fault parameters and coseismic vertical displacement, yielding a value ranging between M 5.9 and M 6.5. Moreover, we dated this paleoearthquake by the paleontological record of a "Lynx pardinus spelaea", with an age of 65 +/- 18 ka BP. Additionally, we have measured the thermal profile of the Benis Cave (-350 m of depth), from single rock point temperature measurements during 2 years. The temperature profile shows three different parts inside the cave, the shallow heterogeneous thermal zone till 50 m depth; the homogeneous thermal zone 150 m till with constant temperature and the hetero-thermal deep zone, deeper than 150 m and till the deepest zone (350 m). Furthermore, we have estimated the Vertical Geothermal Gradient, 1.85 degrees C/100 m for the deepest zone (-150; -290 m). The temperature increases with depth, showing a reverse thermal profile in comparison with normal gradients in deep caves. Finally, we have calculated the heat flux of 0.46 mWm(2). (C) 2016 Elsevier Ltd and INQUA. All rights reserved.
KW  - Speleoseismology
KW  - Active fault
KW  - Cave
KW  - Slip-rate
KW  - Heat flux
Y1  - 2017
U6  - https://doi.org/10.1016/j.quaint.2016.11.026
SN  - 1040-6182
SN  - 1873-4553
VL  - 451
SP  - 165
EP  - 175
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - GEN
A1  - Foster, William J.
A1  - Garvie, Christopher L.
A1  - Weiss, Anna M.
A1  - Muscente, A. Drew
A1  - Aberhan, Martin
A1  - Counts, John W.
A1  - Martindale, Rowan C.
T1  - Resilience of marine invertebrate communities during the early Cenozoic hyperthermals
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1410 
KW  - eocene thermal maximum
KW  - gulf coastal plain
KW  - climate-change
KW  - ocean acidification
KW  - extinction event
KW  - carbon-cycle
KW  - heat-stress
KW  - origination
KW  - ecosystems
KW  - diversity
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516011
SN  - 1866-8372
IS  - 1
ER  - 
TY  - JOUR
A1  - Foster, William J.
A1  - Garvie, Christopher L.
A1  - Weiss, Anna M.
A1  - Muscente, A. Drew
A1  - Aberhan, Martin
A1  - Counts, John W.
A1  - Martindale, Rowan C.
T1  - Resilience of marine invertebrate communities during the early Cenozoic hyperthermals
JF  - Scientific Reports
N2  - The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated.
KW  - eocene thermal maximum
KW  - gulf coastal plain
KW  - climate-change
KW  - ocean acidification
KW  - extinction event
KW  - carbon-cycle
KW  - heat-stress
KW  - origination
KW  - ecosystems
KW  - diversity
Y1  - 2020
U6  - https://doi.org/10.1038/s41598-020-58986-5
SN  - 2045-2322
VL  - 10
IS  - 1
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Kerubo, Leonidah Omosa
A1  - Midiwo, Jacob Ogweno
A1  - Derese, Solomon
A1  - Langat, Moses K.
A1  - Akala, Hoseah M.
A1  - Waters, Norman C.
A1  - Peter, Martin
A1  - Heydenreich, Matthias
T1  - Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus
JF  - Natural product communications : an international journal for communications and reviews
N2  - From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
KW  - Senecio roseiflorus
KW  - Asteraceae
KW  - Surface exudates
KW  - Antiplasmodial activity
Y1  - 2013
SN  - 1934-578X
VL  - 8
IS  - 2
SP  - 175
EP  - 176
PB  - NPC
CY  - Westerville
ER  - 
TY  - JOUR
A1  - Sechi, Antonio
A1  - Freitas, Joana M. G.
A1  - Wünnemann, Patrick
A1  - Töpel, Alexander
A1  - Paschoalin, Rafaella Takehara
A1  - Ullmann, Sabrina
A1  - Schröder, Ricarda
A1  - Aydin, Gülcan
A1  - Rütten, Stephan
A1  - Böker, Alexander
A1  - Zenke, Martin
A1  - Pich, Andrij
T1  - Surface-Grafted Nanogel Arrays Direct Cell Adhesion and Motility
JF  - Advanced materials interfaces
N2  - It has long been appreciated that material chemistry and topology profoundly affect cell adhesion and migration. Here, aqueous poly(N- isopropyl acrylamide) nanogels are designed, synthesized and printed in form of colloidal arrays on glass substrates using wrinkled polydimethylsiloxane templates. Using low-temperature plasma treatment, nanogels are chemically grafted onto glass supports thus leading to highly stable nanogel layers in cell culture media. Liquid cell atomic force microscopy investigations show that surface-grafted nanogels retain their swelling behavior in aqueous media and that extracellular matrix protein coating do not alter their stability and topography. It is demonstrated that surface-grafted nanogels could serve as novel substrates for the analysis of cell adhesion and migration. Nanogels influence size, speed, and dynamics of focal adhesions and cell motility forcing cells to move along highly directional trajectories. Moreover, modulation of nanogel state or spacing serves as an effective tool for regulation of cell motility. It is suggested that nanogel arrays deposited on solid surfaces could be used to provide a precise and tunable system to understand and control cell migration. Additionally, such nanogel arrays will contribute to the development of implantable systems aimed at supporting and enhancing cell migration during, for instance, wound healing and tissue regeneration.
Y1  - 2016
U6  - https://doi.org/10.1002/admi.201600455
SN  - 2196-7350
VL  - 3
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - De Biase, Cecilia
A1  - Reger, Daniel
A1  - Schmidt, Axel
A1  - Jechalke, Sven
A1  - Reiche, Nils
A1  - Martinez-Lavanchy, Paula M.
A1  - Rosell, Monica
A1  - Van Afferden, Manfred
A1  - Maier, Uli
A1  - Oswald, Sascha
A1  - Thullner, Martin
T1  - Treatment of volatile organic contaminants in a vertical flow filter -  relevance of different removal processes
JF  - Ecological engineering : the journal of ecotechnology
N2  - Vertical flow filters and vertical flow constructed wetlands are established wastewater treatment systems and have also been proposed for the treatment of contaminated groundwater. This study investigates the removal processes of volatile organic compounds in a pilot-scale vertical flow filter. The filter is intermittently irrigated with contaminated groundwater containing benzene, MTBE and ammonium as the main contaminants. The system is characterized by unsaturated conditions and high contaminant removal efficiency. The aim of the present study is to evaluate the contribution of biodegradation and volatilization to the overall removal of benzene and MTBE. Tracer tests and flow rate measurements showed a highly transient flow and heterogeneous transport regime. Radon-222, naturally occurring in the treated groundwater, was used as a gas tracer and indicated a high volatilization potential. Radon-222 behavior was reproduced by numerical simulations and extrapolated for benzene and MTBE, and indicated these compounds also have a high volatilization potential. In contrast, passive sampler measurements on top of the filter detected only low benzene and MTBE concentrations. Biodegradation potential was evaluated by the analysis of catabolic genes involved in organic compound degradation and a quantitative estimation of biodegradation was derived from stable isotope fractionation analysis. Results suggest that despite the high volatilization potential, biodegradation is the predominant mass removal process in the filter system, which indicates that the volatilized fraction of the contaminants is still subject to subsequent biodegradation. In particular, the upper filter layer located between the injection tubes and the surface of the system might also contribute to biodegradation, and might play a crucial role in avoiding the emission of volatilized contaminants into the atmosphere.
KW  - Benzene
KW  - Biodegradation
KW  - Catabolic genes
KW  - MTBE
KW  - Numerical modeling
KW  - Radon
KW  - SAFIRA II
KW  - Stable isotope fractionation analysis
KW  - Tracers
KW  - VOCs
KW  - Volatilization
Y1  - 2011
U6  - https://doi.org/10.1016/j.ecoleng.2011.03.023
SN  - 0925-8574
VL  - 37
IS  - 9
SP  - 1292
EP  - 1303
PB  - Elsevier
CY  - Amsterdam
ER  -