TY - JOUR A1 - Mahro, Martin A1 - Bras, Natercia F. A1 - Cerqueira, Nuno M. F. S. A. A1 - Teutloff, Christian A1 - Coelho, Catarina A1 - Romao, Maria Joao A1 - Leimkühler, Silke T1 - Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity JF - PLoS one N2 - In order to elucidate factors that determine substrate specificity and activity of mammalian molybdo-flavoproteins we performed site directed mutagenesis of mouse aldehyde oxidase 3 (mAOX3). The sequence alignment of different aldehyde oxidase (AOX) isoforms identified variations in the active site of mAOX3 in comparison to other AOX proteins and xanthine oxidoreductases (XOR). Based on the structural alignment of mAOX3 and bovine XOR, differences in amino acid residues involved in substrate binding in XORs in comparison to AOXs were identified. We exchanged several residues in the active site to the ones found in other AOX homologues in mouse or to residues present in bovine XOR in order to examine their influence on substrate selectivity and catalytic activity. Additionally we analyzed the influence of the [2Fe-2S] domains of mAOX3 on its kinetic properties and cofactor saturation. We applied UV-VIS and EPR monitored redox-titrations to determine the redox potentials of wild type mAOX3 and mAOX3 variants containing the iron-sulfur centers of mAOX1. In addition, a combination of molecular docking and molecular dynamic simulations (MD) was used to investigate factors that modulate the substrate specificity and activity of wild type and AOX variants. The successful conversion of an AOX enzyme to an XOR enzyme was achieved exchanging eight residues in the active site of mAOX3. It was observed that the absence of the K889H exchange substantially decreased the activity of the enzyme towards all substrates analyzed, revealing that this residue has an important role in catalysis. Y1 - 2013 U6 - https://doi.org/10.1371/journal.pone.0082285 SN - 1932-6203 VL - 8 IS - 12 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Feito Boirac, Alvaro Felipe A1 - Lundeen, Jeff S. A1 - Coldenstrodt-Ronge, Hendrik A1 - Eisert, Jens A1 - Plenio, Martin B. A1 - Walmsley, Ian A. T1 - Measuring measurement : theory and practice N2 - Recent efforts have applied quantum tomography techniques to the calibration and characterization of complex quantum detectors using minimal assumptions. In this work, we provide detail and insight concerning the formalism, the experimental and theoretical challenges and the scope of these tomographical tools. Our focus is on the detection of photons with avalanche photodiodes and photon-number resolving detectors and our approach is to fully characterize the quantum operators describing these detectors with a minimal set of well-specified assumptions. The formalism is completely general and can be applied to a wide range of detectors. Y1 - 2009 UR - http://iopscience.iop.org/1367-2630 U6 - https://doi.org/10.1088/1367-2630/11/9/093038 SN - 1367-2630 ER - TY - JOUR A1 - Trauth, Martin H. A1 - Maslin, Mark A. T1 - Comment on "Diatomaceous sediments and environmental change in the Pleistocene Olorgesailie Formation, southern Kenya Rift" by R.B. Owen, R. Potts, A.K. Behrensmeyer and P. Ditchfield [Palaeogeography, Palaeoclimatology, Palaeoecology 269 (2008) 17-37] N2 - Owen et al. [Owen. R.B.. Potts, R., Behrensmeyer, A.K., Ditchfield, P. 2008. Diatomaceous sediments and environmental change in the Pleistocene Olorgesailie Formation, southern Kenya Rift Valley. Palaeogeography, Palaeochmatology, Palaeoccology, 269. 17-37], Diatomaceous sediments and environmental change in the Pleistocene Olorgesailie Formation. southern Kenya Rift. Palaeogeography Palaeoclimatology Palaeciecology, 269, 17-37) argued that diatom assemblage variations in the Olorgesailie Formation indicate considerable environmental instability with both wetter and drier periods, contradicting the proposed period of lake stability and wet climatic conditions between ca 11 and 0.9 million years ago as proposed by Trauth et al [Trauth, M.H. Maslin, MA.. Demo. A.. Strecker, M R.. 2005. Late Cenozoic moisture history of East Africa. Science 309. 2051-2053., Trauth, M H. Mashn. M.A., Deino, A., Bergner. A G.N.. Diihnforth, M. Strecker. M.R, 2007 High- and low-latitude forcing of Plio-Pleistocene East African climate and hL.man evolution. journal of Human Evolution 53, 475-486] Contrary to the interpretation of our work by O Nen et al. [Owen. R.B, Potts, R. Behrensmeyer, A.K. Ditchfield. P. 2008], we never said that the proposed periods of large lakes were characterized by stable conditions. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/00310182 U6 - https://doi.org/10.1016/j.palaeo.2009.02.030 SN - 0031-0182 ER - TY - JOUR A1 - Plath, Martin A1 - Pfenninger, Markus A1 - Lerp, Hannes A1 - Riesch, Rüdiger A1 - Eschenbrenner, Christoph A1 - Slattery, Patrick A. A1 - Bierbach, David A1 - Herrmann, Nina A1 - Schulte, Matthias A1 - Arias-Rodriguez, Lenin A1 - Rimber Indy, Jeane A1 - Passow, Courtney A1 - Tobler, Michael T1 - Genetic differentiation and selection against migrants in evolutionarily replicated extreme environments JF - Evolution N2 - We investigated mechanisms of reproductive isolation in livebearing fishes (genus Poecilia) inhabiting sulfidic and nonsulfidic habitats in three replicate river drainages. Although sulfide spring fish convergently evolved divergent phenotypes, it was unclear if mechanisms of reproductive isolation also evolved convergently. Using microsatellites, we found strongly reduced gene flow between adjacent populations from different habitat types, suggesting that local adaptation to sulfidic habitats repeatedly caused the emergence of reproductive isolation. Reciprocal translocation experiments indicate strong selection against immigrants into sulfidic waters, but also variation among drainages in the strength of selection against immigrants into nonsulfidic waters. Mate choice experiments revealed the evolution of assortative mating preferences in females from nonsulfidic but not from sulfidic habitats. The inferred strength of sexual selection against immigrants (RIs) was negatively correlated with the strength of natural selection (RIm), a pattern that could be attributed to reinforcement, whereby natural selection strengthens behavioral isolation due to reduced hybrid fitness. Overall, reproductive isolation and genetic differentiation appear to be replicated and direct consequences of local adaptation to sulfide spring environments, but the relative contributions of different mechanisms of reproductive isolation vary across these evolutionarily independent replicates, highlighting both convergent and nonconvergent evolutionary trajectories of populations in each drainage. KW - Ecological speciation KW - isolation-by-adaptation KW - local adaptation KW - Poecilia mexicana KW - reinforcement KW - sexual isolation Y1 - 2013 U6 - https://doi.org/10.1111/evo.12133 SN - 0014-3820 VL - 67 IS - 9 SP - 2647 EP - 2661 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Klaus, Valentin H. A1 - Kleinebecker, Till A1 - Prati, Daniel A1 - Gossner, Martin M. A1 - Alt, Fabian A1 - Boch, Steffen A1 - Gockel, Sonja A1 - Hemp, Andreas A1 - Lange, Markus A1 - Müller, Jörg A1 - Oelmann, Yvonne A1 - Pasalic, Esther A1 - Renner, Swen C. A1 - Socher, Stephanie A. A1 - Türke, Manfred A1 - Weisser, Wolfgang W. A1 - Fischer, Markus A1 - Hölzel, Norbert T1 - Does organic grassland farming benefit plant and arthropod diversity at the expense of yield and soil fertility? JF - Agriculture, ecosystems & environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere N2 - Organic management is one of the most popular strategies to reduce negative environmental impacts of intensive agriculture. However, little is known about benefits for biodiversity and potential worsening of yield under organic grasslands management across different grassland types, i.e. meadow, pasture and mown pasture. Therefore, we studied the diversity of vascular plants and foliage-living arthropods (Coleoptera, Araneae, Heteroptera, Auchenorrhyncha), yield, fodder quality, soil phosphorus concentrations and land-use intensity of organic and conventional grasslands across three study regions in Germany. Furthermore, all variables were related to the time since conversion to organic management in order to assess temporal developments reaching up to 18 years. Arthropod diversity was significantly higher under organic than conventional management, although this was not the case for Araneae, Heteroptera and Auchenorrhyncha when analyzed separately. On the contrary, arthropod abundance, vascular plant diversity and also yield and fodder quality did not considerably differ between organic and conventional grasslands. Analyses did not reveal differences in the effect of organic management among grassland types. None of the recorded abiotic and biotic parameters showed a significant trend with time since transition to organic management, except soil organic phosphorus concentrations which decreased with time. This implies that permanent grasslands respond slower and probably weaker to organic management than crop fields do. However, as land-use intensity and inorganic soil phosphorus concentrations were significantly lower in organic grasslands, overcoming seed and dispersal limitation by re-introducing plant species might be needed to exploit the full ecological potential of organic grassland management. We conclude that although organic management did not automatically increase the diversity of all studied taxa, it is a reasonable and useful way to support agro-biodiversity. KW - Agri-environmental schemes KW - Fertilization KW - Fodder quality KW - Land-use intensity KW - Nitrogen KW - Biomass nutrient concentrations KW - Organic farming KW - Phosphorus KW - Species richness KW - Nutrient availability Y1 - 2013 U6 - https://doi.org/10.1016/j.agee.2013.05.019 SN - 0167-8809 VL - 177 IS - 3 SP - 1 EP - 9 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Bronnikov, K. A. A1 - Kasper, Uwe A1 - Rainer, Martin T1 - Intersecting electric and magnetic p-branes: spherically symmetric solutions T3 - Preprint / Universität Potsdam, Institut für Mathematik Y1 - 1997 VL - 1997, 21 PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Rukunga, G. M. A1 - Muregi, F. W. A1 - Omar, S. A. A1 - Gathirwa, J. W. A1 - Muthaura, C. N. A1 - Peter, Martin G. T1 - Anti-plasmodial activity of the extracts and two sesquiterpenes from Cyperus articulatus N2 - Two sesquiterpenes, corymbolone and mustakone, isolated from the chloroform extract of the rhizomes of Cyperus articulatus, exhibited significant anti-plasmodial properties. Mustakone was approximately ten times more active than corymbolone against the sensitive strains of the Plasmodium falciparum. Y1 - 2008 SN - 0367-326X ER - TY - JOUR A1 - Feito, Alvaro A1 - Lundeen, Jeff A1 - Coldenstrodt-Ronge, Hendrik A1 - Eisert, Jens A1 - Plenio, Martin B. A1 - Walmsley, Ian A. T1 - Measuring measurement : theory and practice N2 - Recent efforts have applied quantum tomography techniques to the calibration and characterization of complex quantum detectors using minimal assumptions. In this work, we provide detail and insight concerning the formalism, the experimental and theoretical challenges and the scope of these tomographical tools. Our focus is on the detection of photons with avalanche photodiodes and photon-number resolving detectors and our approach is to fully characterize the quantum operators describing these detectors with a minimal set of well-specified assumptions. The formalism is completely general and can be applied to a wide range of detectors. Y1 - 2009 UR - http://iopscience.iop.org/1367-2630 U6 - https://doi.org/10.1088/1367-2630/11/9/093038 SN - 1367-2630 ER - TY - JOUR A1 - Lim, Sze Chern A1 - Friemel, Martin A1 - Marum, Justine E. A1 - Tucker, Elena J. A1 - Bruno, Damien L. A1 - Riley, Lisa G. A1 - Christodoulou, John A1 - Kirk, Edwin P. A1 - Boneh, Avihu A1 - DeGennaro, Christine M. A1 - Springer, Michael A1 - Mootha, Vamsi K. A1 - Rouault, Tracey A. A1 - Leimkühler, Silke A1 - Thorburn, David R. A1 - Compton, Alison G. T1 - Mutations in LYRM4, encoding ironsulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes JF - Human molecular genetics N2 - Ironsulfur clusters (ISCs) are important prosthetic groups that define the functions of many proteins. Proteins with ISCs (called ironsulfur or FeS proteins) are present in mitochondria, the cytosol, the endoplasmic reticulum and the nucleus. They participate in various biological pathways including oxidative phosphorylation (OXPHOS), the citric acid cycle, iron homeostasis, heme biosynthesis and DNA repair. Here, we report a homozygous mutation in LYRM4 in two patients with combined OXPHOS deficiency. LYRM4 encodes the ISD11 protein, which forms a complex with, and stabilizes, the sulfur donor NFS1. The homozygous mutation (c.203GT, p.R68L) was identified via massively parallel sequencing of 1000 mitochondrial genes (MitoExome sequencing) in a patient with deficiency of complexes I, II and III in muscle and liver. These three complexes contain ISCs. Sanger sequencing identified the same mutation in his similarly affected cousin, who had a more severe phenotype and died while a neonate. Complex IV was also deficient in her skeletal muscle. Several other FeS proteins were also affected in both patients, including the aconitases and ferrochelatase. Mutant ISD11 only partially complemented for an ISD11 deletion in yeast. Our in vitro studies showed that the l-cysteine desulfurase activity of NFS1 was barely present when co-expressed with mutant ISD11. Our findings are consistent with a defect in the early step of ISC assembly affecting a broad variety of FeS proteins. The differences in biochemical and clinical features between the two patients may relate to limited availability of cysteine in the newborn period and suggest a potential approach to therapy. Y1 - 2013 U6 - https://doi.org/10.1093/hmg/ddt295 SN - 0964-6906 SN - 1460-2083 VL - 22 IS - 22 SP - 4460 EP - 4473 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - De Frenne, Pieter A1 - Rodriguez-Sanchez, Francisco A1 - Coomes, David Anthony A1 - Bäten, Lander A1 - Versträten, Gorik A1 - Vellend, Mark A1 - Bernhardt-Römermann, Markus A1 - Brown, Carissa D. A1 - Brunet, Jörg A1 - Cornelis, Johnny A1 - Decocq, Guillaume M. A1 - Dierschke, Hartmut A1 - Eriksson, Ove A1 - Gilliam, Frank S. A1 - Hedl, Radim A1 - Heinken, Thilo A1 - Hermy, Martin A1 - Hommel, Patrick A1 - Jenkins, Michael A. A1 - Kelly, Daniel L. A1 - Kirby, Keith J. A1 - Mitchell, Fraser J. G. A1 - Naaf, Tobias A1 - Newman, Miles A1 - Peterken, George A1 - Petrik, Petr A1 - Schultz, Jan A1 - Sonnier, Gregory A1 - Van Calster, Hans A1 - Waller, Donald M. A1 - Walther, Gian-Reto A1 - White, Peter S. A1 - Woods, Kerry D. A1 - Wulf, Monika A1 - Graae, Bente Jessen A1 - Verheyen, Kris T1 - Microclimate moderates plant responses to macroclimate warming JF - Proceedings of the National Academy of Sciences of the United States of America N2 - Recent global warming is acting across marine, freshwater, and terrestrial ecosystems to favor species adapted to warmer conditions and/or reduce the abundance of cold-adapted organisms (i.e., "thermophilization" of communities). Lack of community responses to increased temperature, however, has also been reported for several taxa and regions, suggesting that "climatic lags" may be frequent. Here we show that microclimatic effects brought about by forest canopy closure can buffer biotic responses to macroclimate warming, thus explaining an apparent climatic lag. Using data from 1,409 vegetation plots in European and North American temperate forests, each surveyed at least twice over an interval of 12-67 y, we document significant thermophilization of ground-layer plant communities. These changes reflect concurrent declines in species adapted to cooler conditions and increases in species adapted to warmer conditions. However, thermophilization, particularly the increase of warm-adapted species, is attenuated in forests whose canopies have become denser, probably reflecting cooler growing-season ground temperatures via increased shading. As standing stocks of trees have increased in many temperate forests in recent decades, local microclimatic effects may commonly be moderating the impacts of macroclimate warming on forest understories. Conversely, increases in harvesting woody biomass-e.g., for bioenergy-may open forest canopies and accelerate thermophilization of temperate forest biodiversity. KW - climate change KW - forest management KW - understory KW - climatic debt KW - range shifts Y1 - 2013 U6 - https://doi.org/10.1073/pnas.1311190110 SN - 0027-8424 VL - 110 IS - 46 SP - 18561 EP - 18565 PB - National Acad. of Sciences CY - Washington ER - TY - JOUR A1 - Laucht, Manfred A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Stöhr, R.-M. A1 - Weindrich, D. A1 - Ihle, Wolfgang A1 - Marcus, A. T1 - Viereinhalb Jahre danach : Mannheimer Risikokinder im Vorschulalter Y1 - 1996 ER - TY - JOUR A1 - Peter, Martin G. A1 - Köhler, L. A. T1 - Chitin und Chitosan : nachwachsende Rohstoffe aus dem Meer Y1 - 1996 ER - TY - JOUR A1 - López-Franco, Yolanda L. A1 - Calderón de la Barca, Ana M. A1 - Valdez, Miguel A. A1 - Peter, Martin G. A1 - Rinaudo, Marguerite A1 - Chambat, Gérard A1 - Goycoolea, Francisco M. T1 - Structural characterization of mesquite (Prosopis velutina) gum and its fractions N2 - Structural and physicochem. characteristics of mesquite gum (from Prosopis velutina) were investigated using FT- IR spectroscopic, mass spectrometric and chromatog. methods. Four fractions (F-I, F-IIa, F-IIb and F-III) were isolated by hydrophobic interaction chromatog. The samples were characterized and analyzed for their monosaccharide and oligomers compn. by high performance anion-exchange chromatog. with pulsed amperometric detection (HPAEC-PAD). L-Arabinose (L-Ara) and D-galactose (D-Gal) were found as the main carbohydrate constituent residues in the polysaccharides from mesquite gum and their ratio (L-Ara/D-Gal) varied within the range 2.54 to 3.06 among the various fractions. Small amts. of D- glucose (D-Glc), D-mannose (D-Man) and D-xylose (D-Xyl) were also detected, particularly in Fractions IIa, IIb and III. IR spectroscopy identified polysaccharides and protein in all the samples. Data from mass spectrometry (MALDI-TOF MS) was consistent with the idea that the structure corresponding to the periphereal chains of Fraction I is predominantly a chain of pentoses attached to uronic acid. [on SciFinder (R)]. Y1 - 2008 UR - http://www3.interscience.wiley.com/journal/77002860/home?CRETRY=1&SRETRY=0 U6 - https://doi.org/10.1002/mabi.200700285 SN - 1616-5187 ER - TY - THES A1 - Martin, Maria A. T1 - Numerical simulation of the Antartic ice sheet and its dynamic response to external pertubations Y1 - 2012 CY - Potsdam ER - TY - JOUR A1 - Meere, Patrick A. A1 - Mulchrone, Kieran F. A1 - Timmerman, Martin T1 - Shear folding in low-grade metasedimentary rocks - reverse shear along cleavage at a high angle to the maximum compressive stress JF - Geology N2 - Shear folding, which is also referred to as slip folding, involves shear along planes that are oriented approximately parallel to the axial plane of the fold structure. These planes, which are typically axial-planar cleavage planes, facilitate high-angle reverse slip leading to fold limb rotation and amplification. This study builds on recent advances in our understanding of the role of weak fault zones in facilitating slip on misoriented faults; i.e., faults at a high angle to the maximum principal tectonic stress (sigma(1)). Analysis of folded marine sedimentary rocks from the Variscan of southern Ireland provides unambiguous microstructural evidence for reverse shear on chemically weakened cleavage domains. Significant silica loss in these cleavage domains, and as a consequence marked mechanical weakening, is seen as the primary cause for the reverse slip associated with the shear folding of these sedimentary rocks. Y1 - 2013 U6 - https://doi.org/10.1130/G34150.1 SN - 0091-7613 VL - 41 IS - 8 SP - 879 EP - 882 PB - American Institute of Physics CY - Boulder ER - TY - JOUR A1 - Peter, Martin G. A1 - Merz, A. T1 - Stereoselective benzylic deprotonation in the enzymatic rearrangement of N-acetyldopamine derived o-Quinone to the p-Quinone methide Y1 - 1995 SN - 0957-4166 ER - TY - JOUR A1 - Maslin, Mark A. A1 - Trauth, Martin H. T1 - Plio-pleistocene East African pulsed climate variability and its influence on early human evolution Y1 - 2009 SN - 978-1-4020-9979-3 ER - TY - JOUR A1 - Lange, Markus A1 - Türke, Manfred A1 - Pasalic, Esther A1 - Boch, Steffen A1 - Hessenmöller, Dominik A1 - Müller, Jörg A1 - Prati, Daniel A1 - Socher, Stephanie A. A1 - Fischer, Markus A1 - Weisser, Wolfgang W. A1 - Gossner, Martin M. T1 - Effects of forest management on ground-dwelling beetles (Coleoptera; Carabidae, Staphylinidae) in Central Europe are mainly mediated by changes in forest structure JF - Forest ecology and management N2 - Forest management is known to influence species diversity of various taxa but inconsistent or even contrasting effects are reported for arthropods. Regional differences in management as well as differences in regional species pools might be responsible for these inconsistencies, but, inter-regional replicated studies that account for regional variability are rare. We investigated the effect of forest type on the abundance, diversity, community structure and composition of two important ground-dwelling beetle families, Carabidae and Staphylinidae, in 149 forest stands distributed over three regions in Germany. In particular we focused on recent forestry history, stand age and dominant tree species, in addition to a number of environmental descriptors. Overall management effects on beetle communities were small and mainly mediated by structural habitat parameters such as the cover of forest canopy or the plant diversity on forest stands. The general response of both beetle taxa to forest management was similar in all regions: abundance and species richness of beetles was higher in older than in younger stands and species richness was lower in unmanaged than in managed stands. The abundance ratio of forest species-to-open habitat species differed between regions, but generally increased from young to old stands, from coniferous to deciduous stands and from managed to unmanaged stands. The response of both beetle families to dominant tree species was variable among regions and staphylinid richness varied in the response to recent forestry history. Our results suggest that current forest management practices change the composition of ground-dwelling beetle communities mainly by favoring generalists and open habitat species. To protect important forest beetle communities and thus the ecosystem functions and services provided by them, we suggest to shelter remaining ancient forests and to develop near-to-nature management strategies by prolonging rotation periods and increasing structural diversity of managed forests. Possible geographic variations in the response of beetle communities need to be considered in conservation-orientated forest management strategies. (C) 2014 Elsevier B.V. All rights reserved. KW - Beech forest KW - Biodiversity Exploratories KW - Conifer plantations KW - Habitat preferences KW - Insects KW - Land use Y1 - 2014 U6 - https://doi.org/10.1016/j.foreco.2014.06.012 SN - 0378-1127 SN - 1872-7042 VL - 329 SP - 166 EP - 176 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Maslin, Mark A. A1 - Brierley, Chris M. A1 - Milner, Alice M. A1 - Shultz, Susanne A1 - Trauth, Martin H. A1 - Wilson, Katy E. T1 - East African climate pulses and early human evolution JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - Current evidence suggests that all of the major events in hominin evolution have occurred in East Africa. Over the last two decades, there has been intensive work undertaken to understand African palaeoclimate and tectonics in order to put together a coherent picture of how the environment of East Africa has varied in the past. The landscape of East Africa has altered dramatically over the last 10 million years. It has changed from a relatively flat, homogenous region covered with mixed tropical forest, to a varied and heterogeneous environment, with mountains over 4 km high and vegetation ranging from desert to cloud forest. The progressive rifting of East Africa has also generated numerous lake basins, which are highly sensitive to changes in the local precipitation-evaporation regime. There is now evidence that the presence of precession-driven, ephemeral deep-water lakes in East Africa were concurrent with major events in hominin evolution. It seems the unusual geology and climate of East Africa created periods of highly variable local climate, which, it has been suggested could have driven hominin speciation, encephalisation and dispersal out of Africa. One example is the significant hominin speciation and brain expansion event at -1.8 Ma that seems to have been coeval with the occurrence of highly variable, extensive, deep-water lakes. This complex, climatically very variable setting inspired first the variability selection hypothesis, which was then the basis for the pulsed climate variability hypothesis. The newer of the two suggests that the long-term drying trend in East Africa was punctuated by episodes of short, alternating periods of extreme humidity and aridity. Both hypotheses, together with other key theories of climate-evolution linkages, are discussed in this paper. Though useful the actual evolution mechanisms, which led to early hominins are still unclear and continue to be debated. However, it is clear that an understanding of East African lakes and their palaeoclimate history is required to understand the context within which humans evolved and eventually left East Africa. (C) 2014 The Authors. Published by Elsevier Ltd. KW - Human evolution KW - East Africa KW - Palaeoclimatology KW - Palaeoliminology KW - Tectonics KW - Hominin KW - Orbital forcing KW - Cenozoic climate transitions KW - Pulsed climate variability hypothesis Y1 - 2014 U6 - https://doi.org/10.1016/j.quascirev.2014.06.012 SN - 0277-3791 VL - 101 SP - 1 EP - 17 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Simons, Nadja K. A1 - Gossner, Martin M. A1 - Lewinsohn, Thomas M. A1 - Boch, Steffen A1 - Lange, Markus A1 - Müller, Jörg A1 - Pasalic, Esther A1 - Socher, Stephanie A. A1 - Türke, Manfred A1 - Fischer, Markus A1 - Weisser, Wolfgang W. T1 - Resource-mediated indirect effects of grassland management on arthropod diversity JF - PLoS one N2 - Intensive land use is a driving force for biodiversity decline in many ecosystems. In semi-natural grasslands, land-use activities such as mowing, grazing and fertilization affect the diversity of plants and arthropods, but the combined effects of different drivers and the chain of effects are largely unknown. In this study we used structural equation modelling to analyse how the arthropod communities in managed grasslands respond to land use and whether these responses are mediated through changes in resource diversity or resource quantity (biomass). Plants were considered resources for herbivores which themselves were considered resources for predators. Plant and arthropod (herbivores and predators) communities were sampled on 141 meadows, pastures and mown pastures within three regions in Germany in 2008 and 2009. Increasing land-use intensity generally increased plant biomass and decreased plant diversity, mainly through increasing fertilization. Herbivore diversity decreased together with plant diversity but showed no response to changes in plant biomass. Hence, land-use effects on herbivore diversity were mediated through resource diversity rather than quantity. Land-use effects on predator diversity were mediated by both herbivore diversity (resource diversity) and herbivore quantity (herbivore biomass), but indirect effects through resource quantity were stronger. Our findings highlight the importance of assessing both direct and indirect effects of land-use intensity and mode on different trophic levels. In addition to the overall effects, there were subtle differences between the different regions, pointing to the importance of regional land-use specificities. Our study underlines the commonly observed strong effect of grassland land use on biodiversity. It also highlights that mechanistic approaches help us to understand how different land-use modes affect biodiversity. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0107033 SN - 1932-6203 VL - 9 IS - 9 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Caron, Maria Mercedes A1 - De Frenne, Pieter A1 - Brunet, Jörg A1 - Chabrerie, Olivier A1 - Cousins, Sara A. O. A1 - Decocq, Guillaume A1 - Diekmann, Martin A1 - Graae, Bente Jessen A1 - Heinken, Thilo A1 - Kolb, Annette A1 - Lenoir, Jonathan A1 - Naaf, Tobias A1 - Plue, Jan A1 - Selvi, Federico A1 - Wulf, Monika A1 - Verheyen, Kris T1 - Divergent regeneration responses of two closely related tree species to direct abiotic and indirect biotic effects of climate change JF - Forest ecology and management N2 - Changing temperature and precipitation can strongly influence plant reproduction. However, also biotic interactions might indirectly affect the reproduction and recruitment success of plants in the context of climate change. Information about the interactive effects of changes in abiotic and biotic factors is essential, but still largely lacking, to better understand the potential effects of a changing climate on plant populations. Here we analyze the regeneration from seeds of Acer platanoides and Acer pseudoplatanus, two currently secondary forest tree species from seven regions along a 2200 km-wide latitudinal gradient in Europe. We assessed the germination, seedling survival and growth during two years in a common garden experiment where temperature, precipitation and competition with the understory vegetation were manipulated. A. platanoides was more sensitive to changes in biotic conditions while A. pseudoplatanus was affected by both abiotic and biotic changes. In general, competition reduced (in A. platanoides) and warming enhanced (in A. pseudoplatanus) germination and survival, respectively. Reduced competition strongly increased the growth of A. platanoides seedlings. Seedling responses were independent of the conditions experienced by the mother tree during seed production and maturation. Our results indicate that, due to the negative effects of competition on the regeneration of A. platanoides, it is likely that under stronger competition (projected under future climatic conditions) this species will be negatively affected in terms of germination, survival and seedling biomass. Climate-change experiments including both abiotic and biotic factors constitute a key step forward to better understand the response of tree species' regeneration to climate change. (C) 2015 Elsevier B.V. All rights reserved. KW - Acer KW - Regeneration KW - Latitudinal gradient KW - Temperature KW - Precipitation KW - Competition Y1 - 2015 U6 - https://doi.org/10.1016/j.foreco.2015.01.003 SN - 0378-1127 SN - 1872-7042 VL - 342 SP - 21 EP - 29 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Mishra, Praveen Kumar A1 - Anoop, Ambili A1 - Schettler, Georg A1 - Prasad, Sushma A1 - Jehangir, Arshid A1 - Menzel, Peter A1 - Naumann, Rudolf A1 - Yousuf, A. R. A1 - Basavaiah, Nathani A1 - Deenadayalan, Kannan A1 - Wiesner, Martin G. A1 - Gaye, Birgit T1 - Reconstructed late Quaternary hydrological changes from Lake Tso Moriri, NW Himalaya JF - Quaternary international : the journal of the International Union for Quaternary Research N2 - We present the results of our investigations on the radiocarbon dated core sediments from the Lake Tso Moriri, NW Himalaya aimed at reconstructing palaeohydrological changes in this climatically sensitive region. Based on the detailed geochemical, mineralogical and sedimentological analysis, we recognise several short-term fluctuations superimposed upon seven major palaeohydrological stages identified in this lake since similar to 26 cal ka. Stage I (>20.2 cal ka): shallow lake characterised by input of coarse-grained detrital sediments; Stage II (20.2-16.4 cal ka): lake deepening and intensification of this trend ca. 18 cal ka; Stage III (16.4-11.2 cal ka): rising lake levels with a short term wet phase (13.1-11.7 cal ka); Stage IV (11.2-8.5 cal ka): early Holocene hydrological maxima and highest lake levels inferred to have resulted from early Holocene Indian monsoon intensification, as records from central Asia indicate weaker westerlies during this interval; Stage V (8.5-5.5 cal ka): mid-Holocene climate deterioration; Stage VI (5.5-2.7 cal ka): progressive lowering of lake level; Stage VII (2.7-0 cal ka): onset of modern conditions. The reconstructed hydrological variability in Lake Tso Moriri is governed by temperature changes (meltwater inflow) and monsoon precipitation (increased runoff). A regional comparison shows considerable differences with other palaeorecords from peninsular India during late Holocene. (C) 2014 Elsevier Ltd and INQUA. All rights reserved. KW - Authigenic carbonates KW - Holocene KW - Indian summer monsoon KW - Lake sediments KW - Tso Moriri Lake KW - Westerlies Y1 - 2015 U6 - https://doi.org/10.1016/j.quaint.2014.11.040 SN - 1040-6182 SN - 1873-4553 VL - 371 SP - 76 EP - 86 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Teriaca, Luca A1 - Andretta, Vincenzo A1 - Auchere, Frederic A1 - Brown, Charles M. A1 - Buchlin, Eric A1 - Cauzzi, Gianna A1 - Culhane, J. Len A1 - Curdt, Werner A1 - Davila, Joseph M. A1 - Del Zanna, Giulio A1 - Doschek, George A. A1 - Fineschi, Silvano A1 - Fludra, Andrzej A1 - Gallagher, Peter T. A1 - Green, Lucie A1 - Harra, Louise K. A1 - Imada, Shinsuke A1 - Innes, Davina A1 - Kliem, Bernhard A1 - Korendyke, Clarence A1 - Mariska, John T. A1 - Martinez-Pillet, Valentin A1 - Parenti, Susanna A1 - Patsourakos, Spiros A1 - Peter, Hardi A1 - Poletto, Luca A1 - Rutten, Robert J. A1 - Schuehle, Udo A1 - Siemer, Martin A1 - Shimizu, Toshifumi A1 - Socas-Navarro, Hector A1 - Solanki, Sami K. A1 - Spadaro, Daniele A1 - Trujillo-Bueno, Javier A1 - Tsuneta, Saku A1 - Dominguez, Santiago Vargas A1 - Vial, Jean-Claude A1 - Walsh, Robert A1 - Warren, Harry P. A1 - Wiegelmann, Thomas A1 - Winter, Berend A1 - Young, Peter T1 - LEMUR large european module for solar ultraviolet research JF - Experimental astronomy : an international journal on astronomical instrumentation and data analysis N2 - The solar outer atmosphere is an extremely dynamic environment characterized by the continuous interplay between the plasma and the magnetic field that generates and permeates it. Such interactions play a fundamental role in hugely diverse astrophysical systems, but occur at scales that cannot be studied outside the solar system. Understanding this complex system requires concerted, simultaneous solar observations from the visible to the vacuum ultraviolet (VUV) and soft X-rays, at high spatial resolution (between 0.1'' and 0.3''), at high temporal resolution (on the order of 10 s, i.e., the time scale of chromospheric dynamics), with a wide temperature coverage (0.01 MK to 20 MK, from the chromosphere to the flaring corona), and the capability of measuring magnetic fields through spectropolarimetry at visible and near-infrared wavelengths. Simultaneous spectroscopic measurements sampling the entire temperature range are particularly important. These requirements are fulfilled by the Japanese Solar-C mission (Plan B), composed of a spacecraft in a geosynchronous orbit with a payload providing a significant improvement of imaging and spectropolarimetric capabilities in the UV, visible, and near-infrared with respect to what is available today and foreseen in the near future. The Large European Module for solar Ultraviolet Research (LEMUR), described in this paper, is a large VUV telescope feeding a scientific payload of high-resolution imaging spectrographs and cameras. LEMUR consists of two major components: a VUV solar telescope with a 30 cm diameter mirror and a focal length of 3.6 m, and a focal-plane package composed of VUV spectrometers covering six carefully chosen wavelength ranges between 170 and 1270 . The LEMUR slit covers 280'' on the Sun with 0.14'' per pixel sampling. In addition, LEMUR is capable of measuring mass flows velocities (line shifts) down to 2 km s (-aEuro parts per thousand 1) or better. LEMUR has been proposed to ESA as the European contribution to the Solar C mission. KW - Sun: atmosphere KW - Space vehicles: instruments KW - Techniques: spectroscopy KW - ESA cosmic vision Y1 - 2012 U6 - https://doi.org/10.1007/s10686-011-9274-x SN - 0922-6435 VL - 34 IS - 2 SP - 273 EP - 309 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Junginger, Annett A1 - Roller, Sybille A1 - Olaka, Lydia A. A1 - Trauth, Martin H. T1 - The effects of solar irradiation changes on the migration of the Congo Air Boundary and water levels of paleo-Lake Suguta, Northern Kenya Rift, during the African Humid Period (15-5 ka BP) JF - Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences N2 - The water-level record from the 300 m deep paleo-lake Suguta (Northern Kenya Rift) during the African Humid Period (AHP, 15-5 ka BP) helps to explain decadal to centennial intensity variations in the West African Monsoon (WAM) and the Indian Summer Monsoon (ISM). This water-level record was derived from three different sources: (1) grain size variations in radiocarbon dated and reservoir corrected lacustrine sediments, (2) the altitudes and ages of paleo-shorelines within the basin, and (3) the results of hydro-balance modeling, providing important insights into the character of water level variations (abrupt or gradual) in the amplifier paleo-Lake Suguta. The results of these comprehensive analyses suggest that the AHP highstand in the Suguta Valley was the direct consequence of a northeastwards shift in the Congo Air Boundary (CAB), which was in turn caused by an enhanced atmospheric pressure gradient between East Africa and India during a northern hemisphere insolation maximum. Rapidly decreasing water levels of up to 90 m over less than a hundred years are best explained by changes in solar irradiation either reducing the East African-Indian atmospheric pressure gradient and preventing the CAB from reaching the study area, or reducing the overall humidity in the atmosphere, or a combination of both these effects. In contrast, although not well documented in our record we hypothesize a gradual end of the AHP despite an abrupt change in the source of precipitation when a decreasing pressure gradient between Asia and Africa prevented the CAB from reaching the Suguta Valley. The abruptness was probably buffered by a contemporaneous change in precession producing an insolation maximum at the equator during October. Whether or not this is the case, the water-level record from the Suguta Valley demonstrates the importance of both orbitally-controlled insolation variations and short-term changes in solar irradiation as factors affecting the significant water level variations in East African rift lakes. KW - East African Rift System KW - Suguta Valley KW - African Humid Period KW - Congo Air Boundary Y1 - 2014 U6 - https://doi.org/10.1016/j.palaeo.2013.12.007 SN - 0031-0182 SN - 1872-616X VL - 396 SP - 1 EP - 16 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Schurr, Frank Martin A1 - Esler, Karen J. A1 - Slingsby, Jasper A. A1 - Allsopp, Nicky T1 - Fynbos proteaceae as model organisms for biodiversity research and conservation T2 - South African journal of science Y1 - 2012 U6 - https://doi.org/10.4102/sajs.v108i11/12.1446 SN - 0038-2353 VL - 108 IS - 11-12 SP - 10 EP - 13 PB - Academy of Science of South Africa CY - Lynwood Ridge ER - TY - JOUR A1 - Maslin, Mark A. A1 - Pancost, Richard D. A1 - Wilson, Katy E. A1 - Lewis, Jonathan A1 - Trauth, Martin H. T1 - Three and half million year history of moisture availability of South West Africa evidence from ODP site 1085 biomarker records JF - Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences N2 - Ocean Drilling Program Site 1085 provides a continuous marine sediment record off southern South West Africa for at least the last three and half million years. The n-alkane partial derivative(13) C record from this site records changes in past vegetation and provides an indication of the moisture availability of SW Africa during this time period. Very little variation, and no apparent trend, is observed in the n-alkane delta C-13 record, suggesting stable long-term conditions despite significant changes in East African tectonics and global climate. Slightly higher n-alkane delta C-13 values occur between 3.5 and 2.7 Ma suggesting slightly drier conditions than today. Between 2.5 and 2.7 Ma there is a shift to more negative n-alkane delta C-13 values suggesting slightly wetter conditions during a similar to 0.2 Ma episode that coincides with the intensification of Northern Hemisphere Glaciation (iNHG). From 2.5 to 0.4 Ma the n-alkane delta C-13 values are very consistent, varying by less than +/- 0.5 parts per thousand and suggesting little or no long-term change in the moisture availability of South West Africa over the last 2.5 million years. This is in contrast to the long-term drying trend observed further north offshore from the Namib Desert and in East Africa. A comparison of the climate history of these regions suggests that Southern Africa may have been an area of long-term stability over the last 3.5 Myrs. KW - Plio-Pleistocene KW - Aridity KW - SW Africa KW - Biomarkers KW - Palaeoclimate KW - Human evolution Y1 - 2012 U6 - https://doi.org/10.1016/j.palaeo.2011.12.009 SN - 0031-0182 VL - 317 SP - 41 EP - 47 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Koussoroplis, Apostolos-Manuel A1 - Nussbaumer, Julia A1 - Arts, Michael T. A1 - Guschina, Irina A. A1 - Kainz, Martin J. T1 - Famine and feast in a common freshwater calanoid: Effects of diet and temperature on fatty acid dynamics of Eudiaptomus gracilis JF - Limnology and oceanography N2 - We investigated the effects of temperature (4 degrees C, 8 degrees C, and 12 degrees C) on structural and storage dynamics, as measured by changes in fatty acids (FA) associated with cell membrane phospholipids (PL) and triacylglycerols (TAG), respectively, as well as on body weight and survival of a freshwater calanoid copepod (Eudiaptomus gracilis) during fasting (10 d) and refeeding (10 d) with two algae of differing nutritional quality (Cryptomonas ozolinii and Scenedesmus obliquus). Fasting led to 50% loss in body weight, a near total depletion of TAG, and a drastic decrease of the polyunsaturated FA (PUFA) in TAG and PL, indicating their preferential utilization and alterations in membrane function, respectively. Higher temperatures accelerated the decrease of body weight and of PUFA in PL and TAG, and decreased survival. After 10 d of refeeding, copepods partially recovered their initial lipid stores and cell membrane composition. The effects of food quality were temperature dependent: Cryptomonas promoted better recovery (i.e., return to or close to the levels at the beginning of the experiment) of both body weight and TAG at only the two higher temperatures (8 degrees C and 12 degrees C), whereas no recovery was observed at 4 degrees C. Higher temperatures and refeeding on Cryptomonas also had a positive, but minor, influence on the recovery of membrane FA composition. Survival differed among treatments but was lowest at the intermediate temperature (8 degrees C) for both diets. We conclude that temperature changes on the order of 4-8 degrees C significantly influence TAG and PL during fasting periods and interact with food quality to determine the extent of recovery in copepod lipids. Y1 - 2014 U6 - https://doi.org/10.4319/lo.2014.59.3.0947 SN - 0024-3590 SN - 1939-5590 VL - 59 IS - 3 SP - 947 EP - 958 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Türke, Manfred A1 - Andreas, Kerstin A1 - Gossner, Martin M. A1 - Kowalski, Esther A1 - Lange, Markus A1 - Boch, Steffen A1 - Socher, Stephanie A. A1 - Müller, Jörg A1 - Prati, Daniel A1 - Fischer, Markus A1 - Meyhöfer, Rainer A1 - Weisser, Wolfgang W. T1 - Are gastropods, rather than ants, important dispersers of seeds of myrmecochorous forest herbs? JF - The American naturalist : a bi-monthly journal devoted to the advancement and correlation of the biological sciences N2 - Seed dispersal by ants (myrmecochory) is widespread, and seed adaptations to myrmecochory are common, especially in the form of fatty appendices (elaiosomes). In a recent study, slugs were identified as seed dispersers of myrmecochores in a central European beech forest. Here we used 105 beech forest sites to test whether myrmecochore presence and abundance is related to ant or gastropod abundance and whether experimentally exposed seeds are removed by gastropods. Myrmecochorous plant cover was positively related to gastropod abundance but was negatively related to ant abundance. Gastropods were responsible for most seed removal and elaiosome damage, whereas insects (and rodents) played minor roles. These gastropod effects on seeds were independent of region or forest management. We suggest that terrestrial gastropods can generally act as seed dispersers of myrmecochorous plants and even substitute myrmecochory, especially where ants are absent or uncommon. KW - myrmecochory KW - gastropodochory KW - Arion KW - slug KW - seed dispersal Y1 - 2012 U6 - https://doi.org/10.1086/663195 SN - 0003-0147 VL - 179 IS - 1 SP - 124 EP - 131 PB - Univ. of Chicago Press CY - Chicago ER - TY - JOUR A1 - Gossner, Martin M. A1 - Pasalic, Esther A1 - Lange, Markus A1 - Lange, Patricia A1 - Boch, Steffen A1 - Hessenmöller, Dominik A1 - Müller, Jörg A1 - Socher, Stephanie A. A1 - Fischer, Markus A1 - Schulze, Ernst-Detlef A1 - Weisser, Wolfgang W. T1 - Differential responses of herbivores and herbivory to management in temperate Eeuropean beech JF - PLoS one N2 - Forest management not only affects biodiversity but also might alter ecosystem processes mediated by the organisms, i.e. herbivory the removal of plant biomass by plant-eating insects and other arthropod groups. Aiming at revealing general relationships between forest management and herbivory we investigated aboveground arthropod herbivory in 105 plots dominated by European beech in three different regions in Germany in the sun-exposed canopy of mature beech trees and on beech saplings in the understorey. We separately assessed damage by different guilds of herbivores, i.e. chewing, sucking and scraping herbivores, gall-forming insects and mites, and leaf-mining insects. We asked whether herbivory differs among different forest management regimes (unmanaged, uneven-aged managed, even-aged managed) and among age-classes within even-aged forests. We further tested for consistency of relationships between regions, strata and herbivore guilds. On average, almost 80% of beech leaves showed herbivory damage, and about 6% of leaf area was consumed. Chewing damage was most common, whereas leaf sucking and scraping damage were very rare. Damage was generally greater in the canopy than in the understorey, in particular for chewing and scraping damage, and the occurrence of mines. There was little difference in herbivory among differently managed forests and the effects of management on damage differed among regions, strata and damage types. Covariates such as wood volume, tree density and plant diversity weakly influenced herbivory, and effects differed between herbivory types. We conclude that despite of the relatively low number of species attacking beech; arthropod herbivory on beech is generally high. We further conclude that responses of herbivory to forest management are multifaceted and environmental factors such as forest structure variables affecting in particular microclimatic conditions are more likely to explain the variability in herbivory among beech forest plots. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0104876 SN - 1932-6203 VL - 9 IS - 8 PB - PLoS CY - San Fransisco ER - TY - GEN A1 - Yan, Robert A1 - Friemel, Martin A1 - Aloisi, Claudia A1 - Huynen, Martijn A1 - Taylor, Ian A. A1 - Leimkühler, Silke A1 - Pastore, Annalisa T1 - The eukaryotic-specific Isd11 is a complex- orphan protein with ability to bind the prokaryotic IscS T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The eukaryotic protein Isd11 is a chaperone that binds and stabilizes the central component of the essential metabolic pathway responsible for formation of iron-sulfur clusters in mitochondria, the desulfurase Nfs1. Little is known about the exact role of Isd11. Here, we show that human Isd11 (ISD11) is a helical protein which exists in solution as an equilibrium between monomer, dimeric and tetrameric species when in the absence of human Nfs1 (NFS1). We also show that, surprisingly, recombinant ISD11 expressed in E. coli co-purifies with the bacterial orthologue of NFS1, IscS. Binding is weak but specific suggesting that, despite the absence of Isd11 sequences in bacteria, there is enough conservation between the two desulfurases to retain a similar mode of interaction. This knowledge may inform us on the conservation of the mode of binding of Isd11 to the desulfurase. We used evolutionary evidence to suggest Isd11 residues involved in the interaction. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 551 KW - sulfur cluster formation KW - Escherichia coli KW - cysteine desulfurase KW - interacting protein KW - bacterial frataxin KW - statistical-model KW - biogenesis KW - biosynthesis KW - NFS1 KW - deficiency Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-411906 SN - 1866-8372 IS - 551 ER - TY - JOUR A1 - Garofalo, F. A1 - Foti, S. A1 - Hollender, F. A1 - Bard, Pierre-Yves A1 - Cornou, C. A1 - Cox, B. R. A1 - Ohrnberger, Matthias A1 - Sicilia, D. A1 - Asten, M. A1 - Di Giulio, G. A1 - Forbriger, T. A1 - Guillier, B. A1 - Hayashi, K. A1 - Martin, A. A1 - Matsushima, Satoru A1 - Mercerat, D. A1 - Poggi, V. A1 - Yamanaka, H. T1 - InterPACIFIC project: Comparison of invasive and non-invasive methods for seismic site characterization. Part I: Intra-comparison of surface wave methods JF - Soil Dynamics and Earthquake Engineering N2 - The main scope of the InterPACIFIC (Intercomparison of methods for site parameter and velocity profile characterization) project is to assess the reliability of in-hole and surface-wave methods, used for estimating shear wave velocity. Three test-sites with different subsurface conditions were chosen: a soft soil, a stiff soil and a rock outcrop. This paper reports the surface-wave methods results. Specifically 14 teams of expert users analysed the same experimental surface-wave datasets, consisting of both passive and active data. Each team adopted their own strategy to retrieve the dispersion curve and the shear-wave velocity profile at each site. Despite different approaches, the dispersion curves are quite in agreement with each other. Conversely, the shear-wave velocity profiles show a certain variability that increases in correspondence of major stratigraphic interfaces. This larger variability is mainly due to non-uniqueness of the solution and lateral variability. As expected, the observed variability in V-s,V-30 estimatesis small, as solution non-uniqueness plays a limited role. (C) 2015 Elsevier Ltd. All rights reserved. KW - Surface-wave methods KW - Dispersion curve KW - Inversion KW - V-s,V-30 KW - Site characterization KW - MASW KW - Microtremors KW - Rayleigh waves KW - Geophysical methods Y1 - 2016 U6 - https://doi.org/10.1016/j.soildyn.2015.12.010 SN - 0267-7261 SN - 1879-341X VL - 82 SP - 222 EP - 240 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Turner, Monica L. A1 - Schaye, Joop A1 - Crain, Robert A. A1 - Theuns, Tom A1 - Wendt, Martin T1 - Observations of metals in the z approximate to 3.5 intergalactic medium and comparison to the EAGLE simulations JF - Monthly notices of the Royal Astronomical Society N2 - We study the z approximate to 3.5 intergalactic medium (IGM) by comparing new, high-quality absorption spectra of eight QSOs with < z(QSO)> = 3.75, to virtual observations of the Evolution and Assembly of Galaxies and their Environments (EAGLE) cosmological hydrodynamical simulations. We employ the pixel optical depth method and uncover strong correlations between various combinations of H I, C III, C IV, Si III, Si IV, and O VI. We find good agreement between many of the simulated and observed correlations, including tau(O) (VI) (tau(H) (I)). However, the observed median optical depths for the tau(C) (IV) (tau(H) (I)) and tau(Si) (IV) (tau(H) (I)) relations are higher than those measured from the mock spectra. The discrepancy increases from up to approximate to 0.1 dex at tau(H) (I) = 1 to approximate to 1 dex at tau(H) (I) = 10(2), where we are likely probing dense regions at small galactocentric distances. As possible solutions, we invoke (a) models of ionizing radiation softened above 4 Ryd to account for delayed completion of He II reionization; (b) simulations run at higher resolution; (c) the inclusion of additional line broadening due to unresolved turbulence; and (d) increased elemental abundances; however, none of these factors can fully explain the observed differences. Enhanced photoionization of H I by local sources, which was not modelled, could offer a solution. However, the much better agreement with the observed O VI(H I) relation, which we find probes a hot and likely collisionally ionized gas phase, indicates that the simulations are not in tension with the hot phase of the IGM, and suggests that the simulated outflows may entrain insufficient cool gas. KW - galaxies: formation KW - intergalactic medium KW - quasars: absorption lines Y1 - 2016 U6 - https://doi.org/10.1093/mnras/stw1816 SN - 0035-8711 SN - 1365-2966 VL - 462 SP - 2440 EP - 2464 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Völler, Heinz A1 - Eichler, Sarah A1 - Harnath, A. A1 - Nothroff, Jörg A1 - Butter, Christian A1 - Schikora, Martin A1 - Wegscheider, Karl A1 - Salzwedel, Annett T1 - Multicomponent cardiac rehabilitation in patients after transcatheter aortic valve implantation (TAVI) - course of functioning and quality of life T2 - European heart journal Y1 - 2016 SN - 0195-668X SN - 1522-9645 VL - 37 SP - 542 EP - 542 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Yan, Robert A1 - Friemel, Martin A1 - Aloisi, Claudia A1 - Huynen, Martijn A1 - Taylor, Ian A. A1 - Leimkühler, Silke A1 - Pastore, Annalisa T1 - The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS JF - PLoS one N2 - The eukaryotic protein Isd11 is a chaperone that binds and stabilizes the central component of the essential metabolic pathway responsible for formation of iron-sulfur clusters in mitochondria, the desulfurase Nfs1. Little is known about the exact role of Isd11. Here, we show that human Isd11 (ISD11) is a helical protein which exists in solution as an equilibrium between monomer, dimeric and tetrameric species when in the absence of human Nfs1 (NFS1). We also show that, surprisingly, recombinant ISD11 expressed in E. coli co-purifies with the bacterial orthologue of NFS1, IscS. Binding is weak but specific suggesting that, despite the absence of Isd11 sequences in bacteria, there is enough conservation between the two desulfurases to retain a similar mode of interaction. This knowledge may inform us on the conservation of the mode of binding of Isd11 to the desulfurase. We used evolutionary evidence to suggest Isd11 residues involved in the interaction. Y1 - 2016 U6 - https://doi.org/10.1371/journal.pone.0157895 SN - 1932-6203 VL - 11 SP - 383 EP - 395 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Maslin, Mark A. A1 - Shultz, Susanne A1 - Trauth, Martin H. T1 - A synthesis of the theories and concepts of early human evolution JF - Philosophical transactions of the Royal Society of London : B, Biological sciences N2 - Current evidence suggests that many of the major events in hominin evolution occurred in East Africa. Hence, over the past two decades, there has been intensive work undertaken to understand African palaeoclimate and tectonics in order to put together a coherent picture of how the environment of Africa has varied over the past 10 Myr. A new consensus is emerging that suggests the unusual geology and climate of East Africa created a complex, environmentally very variable setting. This new understanding of East African climate has led to the pulsed climate variability hypothesis that suggests the long-term drying trend in East Africa was punctuated by episodes of short alternating periods of extreme humidity and aridity which may have driven hominin speciation, encephalization and dispersals out of Africa. This hypothesis is unique as it provides a conceptual framework within which other evolutionary theories can be examined: first, at macro-scale comparing phylogenetic gradualism and punctuated equilibrium; second, at a more focused level of human evolution comparing allopatric speciation, aridity hypothesis, turnover pulse hypothesis, variability selection hypothesis, Red Queen hypothesis and sympatric speciation based on sexual selection. It is proposed that each one of these mechanisms may have been acting on hominins during these short periods of climate variability, which then produce a range of different traits that led to the emergence of new species. In the case of Homo erectus (sensu lato), it is not just brain size that changes but life history (shortened inter-birth intervals, delayed development), body size and dimorphism, shoulder morphology to allow thrown projectiles, adaptation to long-distance running, ecological flexibility and social behaviour. The future of evolutionary research should be to create evidence-based meta-narratives, which encompass multiple mechanisms that select for different traits leading ultimately to speciation. KW - human evolution KW - East Africa KW - palaeoclimatology KW - hominin KW - pulsed climate variability framework Y1 - 2015 U6 - https://doi.org/10.1098/rstb.2014.0064 SN - 0962-8436 SN - 1471-2970 VL - 370 IS - 1663 PB - Royal Society CY - London ER - TY - JOUR A1 - Weinelt, Mara A1 - Kuhnt, Wolfgang A1 - Sarnthein-Lotichius, Johann Michael A1 - Altenbach, Alexander V. A1 - Costello, O. A1 - Erlenkeuser, Helmut A1 - Mathiessen, J. A1 - Pflaumann, Uwe A1 - Simstich, J. A1 - Struck, J. A1 - Thies, A. A1 - Trauth, Martin H. A1 - Vogelsang, E. T1 - Paleoceanographic proxies in the northern North Atlantic Y1 - 2001 SN - 3-540-67231-1 ER - TY - JOUR A1 - Altenbach, Alexander V. A1 - Pflaum, U. A1 - Scheibel, Thomas R. A1 - Thies, A. A1 - Timm, M. A1 - Trauth, Martin H. T1 - Scaling percentages of benthic forminifera with flux rates of organic carbon Y1 - 1999 ER - TY - JOUR A1 - Bronnikov, K. A. A1 - Kasper, Uwe A1 - Rainer, Martin T1 - Intersecting electric and magnetic p-brains : spherically symmetric solutions Y1 - 1999 ER - TY - GEN A1 - Lara, Mark J. A1 - Nitze, Ingmar A1 - Grosse, Guido A1 - Martin, Philip A1 - McGuire, A. David T1 - Reduced arctic tundra productivity linked with landform and climate change interactions T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - Arctic tundra ecosystems have experienced unprecedented change associated with climate warming over recent decades. Across the Pan-Arctic, vegetation productivity and surface greenness have trended positively over the period of satellite observation. However, since 2011 these trends have slowed considerably, showing signs of browning in many regions. It is unclear what factors are driving this change and which regions/landforms will be most sensitive to future browning. Here we provide evidence linking decadal patterns in arctic greening and browning with regional climate change and local permafrost-driven landscape heterogeneity. We analyzed the spatial variability of decadal-scale trends in surface greenness across the Arctic Coastal Plain of northern Alaska (similar to 60,000 km(2)) using the Landsat archive (1999-2014), in combination with novel 30 m classifications of polygonal tundra and regional watersheds, finding landscape heterogeneity and regional climate change to be the most important factors controlling historical greenness trends. Browning was linked to increased temperature and precipitation, with the exception of young landforms (developed following lake drainage), which will likely continue to green. Spatiotemporal model forecasting suggests carbon uptake potential to be reduced in response to warmer and/or wetter climatic conditions, potentially increasing the net loss of carbon to the atmosphere, at a greater degree than previously expected. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 550 KW - winter warming events KW - permafrost KW - Alaska KW - trends KW - ice KW - CO2 KW - degradation KW - landscapes KW - ecosystem KW - exchange Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-423132 SN - 1866-8372 IS - 550 ER - TY - JOUR A1 - Fischer, Martin H. A1 - Miklashevsky, Alex A. A1 - Shaki, Samuel T1 - Commentary : The Developmental Trajectory of the Operational Momentum Effect JF - Frontiers in Psychology KW - embodied cognition KW - operational momentum KW - SNARC effect KW - mental arithmetic KW - numerical cognition Y1 - 2018 U6 - https://doi.org/10.3389/fpsyg.2018.02259 SN - 1664-1078 N1 - A Commentary on The Developmental Trajectory of the Operational Momentum Effect by Pinheiro-Chagas, P., Didino, D., Haase, V. G., Wood, G., and Knops, A. (2018). Front. Psychol. 9:1062 doi: 10.3389/fpsyg.2018.01062 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Fischer, Martin H. A1 - Miklashevsky, Alex A. A1 - Shaki, Samuel T1 - Commentary : The Developmental Trajectory of the Operational Momentum Effect T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 502 KW - embodied cognition KW - operational momentum KW - SNARC effect KW - mental arithmetic KW - numerical cognition Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-423169 SN - 1866-8364 N1 - A Commentary on The Developmental Trajectory of the Operational Momentum Effect by Pinheiro-Chagas, P., Didino, D., Haase, V. G., Wood, G., and Knops, A. (2018). Front. Psychol. 9:1062 doi: 10.3389/fpsyg.2018.01062 IS - 502 ER - TY - JOUR A1 - Renteria, Miguel E. A1 - Schmaal, L. A1 - Hibar, D. P. A1 - Couvy-Duchesne, B. A1 - Strike, L. T. A1 - Mills, N. T. A1 - de Zubicaray, Greig. I. A1 - McMahon, Katie. L. A1 - Medland, Sarah E. A1 - Gillespie, N. A. A1 - Hatton, S. N. A1 - Lagopoulos, J. A1 - Veltman, D. J. A1 - van der Wee, N. A1 - van Erp, T. G. M. A1 - Wittfeld, K. A1 - Grabe, H. J. A1 - Block, Andrea A1 - Hegenscheid, K. A1 - Voelzke, H. A1 - Veer, I. M. A1 - Walter, H. A1 - Schnell, K. A1 - Schramm, E. A1 - Normann, C. A1 - Schoepf, Dieter A1 - Konrad, C. A1 - Zurowski, B. A1 - Godlewska, B. R. A1 - Cowen, P. J. A1 - Penninx, B. W. J. H. A1 - Jahanshad, N. A1 - Thompson, Paul M. A1 - Wright, M. J. A1 - Martin, N. G. A1 - Christensen, H. A1 - Hickie, I. B. T1 - Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group JF - Translational Psychiatry Y1 - 2017 U6 - https://doi.org/10.1038/tp.2017.84 SN - 2158-3188 VL - 7 SP - 2301 EP - 2320 PB - Nature Publ. Group CY - New York ER - TY - GEN A1 - Miklashevsky, Alex A. A1 - Fischer, Martin H. T1 - Commentary: Down with Retirement: Implications of Embodied Cognition for Healthy Aging T2 - Frontiers in psychology KW - child development KW - embodied cognition KW - lifespan KW - mobile phone KW - tablet computers KW - digital technologies Y1 - 2017 U6 - https://doi.org/10.3389/fpsyg.2017.00599 SN - 1664-1078 VL - 8 SP - 9 EP - 22 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Hernandez, Martin A. A1 - Gleixner, Gerd A1 - Sachse, Dirk A1 - Alvarez, Hector M. T1 - Carbon Allocation in Rhodococcus jostii RHA1 in Response to Disruption and Overexpression of nlpR Regulatory Gene, Based on C-13-labeling Analysis JF - Frontiers in microbiology N2 - Nitrogen lipid regulator (NlpR) is a pleiotropic regulator that positively controls genes associated with both nitrogen and lipid metabolism in the oleaginous bacterium Rhodococcus jostii RHA1. In this study, we investigated the effect of nlpR disruption and overexpression on the assimilation of C-13-labeled glucose as carbon source, during cultivation of cells under nitrogen-limiting and nitrogen-rich conditions, respectively. Label incorporation into the total lipid extract (TLE) fraction was about 30% lower in the mutant strain in comparison with the wild type strain under low-nitrogen conditions. Moreover, a higher C-13 abundance (similar to 60%) into the extracellular polymeric substance fraction was observed in the mutant strain, nlpR disruption also promoted a decrease in the label incorporation into several TLE-derivative fractions including neutral lipids (NL), glycolipids (GL), phospholipids (PL), triacylglycerols (TAG), diacylglycerols (DAG), and free fatty acids (FFA), with the DAG being the most affected. In contrast, the nlpR overexpression in RHA1 cells under nitrogen-rich conditions produced an increase of the label incorporation into the TLE and its derivative NL and PL fractions, the last one being the highest C-13 enriched. In addition, a higher C-13 enrichment occurred in the TAG, DAG, and FFA fractions after nlpR induction, with the FFA fraction being the most affected within the TLE. Isotopic-labeling experiments demonstrated that NlpR regulator is contributing in oleaginous phenotype of R. jostii RHA1 to the allocation of carbon into the different lipid fractions in response to nitrogen levels, increasing the rate of carbon flux into lipid metabolism. KW - Rhodococcus KW - RHA1 KW - NlpR KW - regulation KW - C-13-glucose KW - lipid metabolism Y1 - 2017 U6 - https://doi.org/10.3389/fmicb.2017.01992 SN - 1664-302X VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Köslin-Findeklee, Fabian A1 - Rizi, Vajiheh Safavi A1 - Becker, Martin A. A1 - Parra-Londono, Sebastian A1 - Arif, Muhammad A1 - Balazadeh, Salma A1 - Müller-Röber, Bernd A1 - Kunze, Reinhard A1 - Horst, Walter J. T1 - Transcriptomic analysis of nitrogen starvation- and cultivar-specific leaf senescence in winter oilseed rape (Brassica napus L.) JF - Plant science : an international journal of experimental plant biology N2 - High nitrogen (N) efficiency, characterized by high grain yield under N limitation, is an important agricultural trait in Brassica napus L. cultivars related to delayed senescence of older leaves during reproductive growth (a syndrome called stay-green). The aim of this study was thus to identify genes whose expression is specifically altered during N starvation-induced leaf senescence and that can be used as markers to distinguish cultivars at early stages of senescence prior to chlorophyll loss. To this end, the transcriptomes of leaves of two B. napus cultivars differing in stay-green characteristics and N efficiency were analyzed 4 days after the induction of senescence by either N starvation, leaf shading or detaching. In addition to N metabolism genes, N starvation mostly (and specifically) repressed genes related to photosynthesis, photorespiration and cell-wall structure, while genes related to mitochondrial electron transport and flavonoid biosynthesis were predominately up-regulated. A kinetic study over a period of 12 days with four B. napus cultivars differing in their stay-green characteristics confirmed the cultivar-specific regulation of six genes in agreement with their senescence behavior: the senescence regulator ANAC029, the anthocyanin synthesis-related genes ANS and DFR-like1, the ammonium transporter AMT1:4, the ureide transporter UPSS, and SPS1 involved in sucrose biosynthesis. The identified genes represent markers for the detection of cultivar-specific differences in N starvation-induced leaf senescence and can thus be employed as valuable tools in B. napus breeding. (C) 2015 Elsevier Ireland Ltd. All rights reserved. KW - Brassica napus KW - Genotypic differences KW - Leaf senescence KW - Molecular marker KW - N efficiency KW - Stay-green Y1 - 2015 U6 - https://doi.org/10.1016/j.plantsci.2014.11.018 SN - 0168-9452 VL - 233 SP - 174 EP - 185 PB - Elsevier CY - Clare ER - TY - JOUR A1 - Koc, Julian A1 - Schardt, Lisa A1 - Nolte, Kim A1 - Beyer, Cindy A1 - Eckhard, Till A1 - Schwiderowski, Philipp A1 - Clarke, Jessica L. A1 - Finlay, John A. A1 - Clare, Anthony S. A1 - Muhler, Martin A1 - Laschewsky, André A1 - Rosenhahn, Axel T1 - Effect of dipole orientation in mixed, charge-equilibrated self-assembled monolayers on protein adsorption and marine biofouling JF - ACS applied materials & interfaces N2 - While zwitterionic interfaces are known for their excellent low-fouling properties, the underlying molecular principles are still under debate. In particular, the role of the zwitterion orientation at the interface has been discussed recently. For elucidation of the effect of this parameter, self-assembled monolayers (SAMs) on gold were prepared from stoichiometric mixtures of oppositely charged alkyl thiols bearing either a quaternary ammonium or a carboxylate moiety. The alkyl chain length of the cationic component (11-mercaptoundecyl)-N,N,N-trimethylammonium, which controls the distance of the positively charged end group from the substrate's surface, was kept constant. In contrast, the anionic component and, correspondingly, the distance of the negatively charged carboxylate groups from the surface was varied by changing the alkyl chain length in the thiol molecules from 7 (8-mercaptooctanoic acid) to 11 (12-mercaptododecanoic acid) to 15 (16-mercaptohexadecanoic acid). In this way, the charge neutrality of the coating was maintained, but the charged groups exposed at the interface to water were varied, and thus, the orientation of the dipoles in the SAMs was altered. In model biofouling studies, protein adsorption, diatom accumulation, and the settlement of zoospores were all affected by the altered charge distribution. This demonstrates the importance of the dipole orientation in mixed-charged SAMs for their inertness to nonspecific protein adsorption and the accumulation of marine organisms. Overall, biofouling was lowest when both the anionic and the cationic groups were placed at the same distance from the substrate's surface. KW - SAM KW - antifouling coatings KW - zwitterionic KW - XPS KW - Navicula perminuta KW - Ulva linza KW - SPR Y1 - 2020 U6 - https://doi.org/10.1021/acsami.0c11580 SN - 1944-8244 SN - 1944-8252 VL - 12 IS - 45 SP - 50953 EP - 50961 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Toy, Virginia Gail A1 - Sutherland, Rupert A1 - Townend, John A1 - Allen, Michael J. A1 - Becroft, Leeza A1 - Boles, Austin A1 - Boulton, Carolyn A1 - Carpenter, Brett A1 - Cooper, Alan A1 - Cox, Simon C. A1 - Daube, Christopher A1 - Faulkner, D. R. A1 - Halfpenny, Angela A1 - Kato, Naoki A1 - Keys, Stephen A1 - Kirilova, Martina A1 - Kometani, Yusuke A1 - Little, Timothy A1 - Mariani, Elisabetta A1 - Melosh, Benjamin A1 - Menzies, Catriona D. A1 - Morales, Luiz A1 - Morgan, Chance A1 - Mori, Hiroshi A1 - Niemeijer, Andre A1 - Norris, Richard A1 - Prior, David A1 - Sauer, Katrina A1 - Schleicher, Anja Maria A1 - Shigematsu, Norio A1 - Teagle, Damon A. H. A1 - Tobin, Harold A1 - Valdez, Robert A1 - Williams, Jack A1 - Yeo, Samantha A1 - Baratin, Laura-May A1 - Barth, Nicolas A1 - Benson, Adrian A1 - Boese, Carolin A1 - Célérier, Bernard A1 - Chamberlain, Calum J. A1 - Conze, Ronald A1 - Coussens, Jamie A1 - Craw, Lisa A1 - Doan, Mai-Linh A1 - Eccles, Jennifer A1 - Grieve, Jason A1 - Grochowski, Julia A1 - Gulley, Anton A1 - Howarth, Jamie A1 - Jacobs, Katrina A1 - Janku-Capova, Lucie A1 - Jeppson, Tamara A1 - Langridge, Robert A1 - Mallyon, Deirdre A1 - Marx, Ray A1 - Massiot, Cécile A1 - Mathewson, Loren A1 - Moore, Josephine A1 - Nishikawa, Osamu A1 - Pooley, Brent A1 - Pyne, Alex A1 - Savage, Martha K. A1 - Schmitt, Doug A1 - Taylor-Offord, Sam A1 - Upton, Phaedra A1 - Weaver, Konrad C. A1 - Wiersberg, Thomas A1 - Zimmer, Martin T1 - Bedrock geology of DFDP-2B, central Alpine Fault, New Zealand JF - New Zealand journal of geology and geophysics : an international journal of the geoscience of New Zealand, the Pacific Rim, and Antarctica ; NZJG N2 - During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled. KW - Alpine Fault KW - New Zealand KW - scientific drilling KW - mylonite KW - cataclasite Y1 - 2017 U6 - https://doi.org/10.1080/00288306.2017.1375533 SN - 0028-8306 SN - 1175-8791 VL - 60 IS - 4 SP - 497 EP - 518 PB - Taylor & Francis CY - Abingdon ER - TY - GEN A1 - Kühne, Katharina A1 - Fischer, Martin H. A1 - Jeglinski-Mende, Melinda A. T1 - During the COVID-19 pandemic participants prefer settings with a face mask, no interaction and at a closer distance T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Peripersonal space is the space surrounding our body, where multisensory integration of stimuli and action execution take place. The size of peripersonal space is flexible and subject to change by various personal and situational factors. The dynamic representation of our peripersonal space modulates our spatial behaviors towards other individuals. During the COVID-19 pandemic, this spatial behavior was modified by two further factors: social distancing and wearing a face mask. Evidence from offline and online studies on the impact of a face mask on pro-social behavior is mixed. In an attempt to clarify the role of face masks as pro-social or anti-social signals, 235 observers participated in the present online study. They watched pictures of two models standing at three different distances from each other (50, 90 and 150 cm), who were either wearing a face mask or not and were either interacting by initiating a hand shake or just standing still. The observers’ task was to classify the model by gender. Our results show that observers react fastest, and therefore show least avoidance, for the shortest distances (50 and 90 cm) but only when models wear a face mask and do not interact. Thus, our results document both pro- and anti-social consequences of face masks as a result of the complex interplay between social distancing and interactive behavior. Practical implications of these findings are discussed. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 783 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-562189 SN - 1866-8364 SP - 1 EP - 12 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Chemura, Sitshengisiwe A1 - Haubitz, Toni A1 - Primus, Philipp A. A1 - Underberg, Martin A1 - Hülser, Tim A1 - Kumke, Michael Uwe T1 - Europium-doped Ceria-Gadolinium mixed oxides BT - PARAFAC analysis and high-resolution emission spectroscopy under cryogenic conditions for structural analysis JF - The journal of physical chemistry : A, Molecules, spectroscopy, kinetics, environment & general theory N2 - Gadolinium-doped ceria or gadolinium-stabilized ceria (GDC) is an important technical material due to its ability to conduct O2- ions, e.g., used in solid oxide fuel cells operated at intermediate temperature as an electrolyte, diffusion barrier, and electrode component. We have synthesized Ce1-xGdxO2-y:Eu3+ (0 <= x <= 0.4) nanoparticles (11-15 nm) using a scalable spray pyrolysis method, which allows the continuous large-scale technical production of such materials. Introducing Eu3+ ions in small amounts into ceria and GDC as spectroscopic probes can provide detailed information about the atomic structure and local environments and allows us to monitor small structural changes. This study presents a novel approach to structurally elucidate europium-doped Ce1-xGdxO2-y:Eu3+ nanoparticles by way of Eu3+ spectroscopy, processing the spectroscopic data with the multiway decomposition method parallel factor (PARAFAC) analysis. In order to perform the deconvolution of spectra, data sets of excitation wavelength, emission wavelength, and time are required. Room temperature, time-resolved emission spectra recorded at lambda(ex) = 464 nm show that Gd3+ doping results in significantly altered emission spectra compared to pure ceria. The PARAFAC analysis for the pure ceria samples reveals a high-symmetry species (which can also be probed directly via the CeO2 charge transfer band) and a low-symmetry species. The GDC samples yield two low-symmetry spectra in the same experiment. High-resolution emission spectra recorded under cryogenic conditions after probing the D-5(0)-F-7(0) transition at lambda(ex) = 575-583 nm revealed additional variation in the low-symmetry Eu3+ sites in pure ceria and GDC. The total luminescence spectra of CeO2-y:Eu3+ showed Eu3+ ions located in at least three slightly different coordination environments with the same fundamental symmetry, whereas the overall hypsochromic shift and increased broadening of the D-5(0)-F-7(0) excitation in the GDC samples, as well as the broadened spectra after deconvolution point to less homogeneous environments. The data of the Gd3+-containing samples indicates that the average charge density around the Eu3+ ions in the lattice is decreased with increasing Gd3+ and oxygen vacancy concentration. For reference, the Judd-Ofelt parameters of all spectra were calculated. PARAFAC proves to be a powerful tool to analyze lanthanide spectra in crystalline solid materials, which are characterized by numerous Stark transitions and where measurements usually yield a superposition of different contributions to any given spectrum. Y1 - 2020 U6 - https://doi.org/10.1021/acs.jpca.0c03188 SN - 1089-5639 SN - 1520-5215 VL - 124 IS - 24 SP - 4972 EP - 4983 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Hermanussen, Michael A1 - Lieberman, Leslie Su A1 - Janewa, V. Schoenfeld A1 - Scheffler, Christiane A1 - Ghosh, Arunava A1 - Bogin, Barry A1 - Godina, Elena A1 - Kaczmarek, M. A1 - El-Shabrawi, M. A1 - Salama, E. E. A1 - Rühli, Frank J. A1 - Staub, Kaspar A1 - Woitek, U. A1 - Blaha, Pawel A1 - Aßmann, Christian A1 - van Buuren, Stef A1 - Lehmann, A. A1 - Satake, T. A1 - Thodberg, H. H. A1 - Jopp, E. A1 - Kirchengast, S. A1 - Tutkuviene, J. A1 - McIntyre, M. H. A1 - Wittwer-Backofen, U. A1 - Boldsen, Jesper L. A1 - Martin, D. D. A1 - Meier, J. T1 - Diversity in auxology between theory and practice JF - Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft für Anthropologie N2 - Auxology has developed from mere describing child and adolescent growth into a vivid and interdisciplinary research area encompassing human biologists, physicians, social scientists, economists and biostatisticians. The meeting illustrated the diversity in auxology, with the various social, medical, biological and biostatistical aspects in studies on child growth and development. KW - child growth KW - adolescent growth KW - child development KW - height KW - weight KW - body mass KW - socio-economic environment Y1 - 2012 U6 - https://doi.org/10.1127/0003-5548/2012/0133 SN - 0003-5548 VL - 69 IS - 2 SP - 159 EP - 174 PB - Schweizerbart CY - Stuttgart ER - TY - JOUR A1 - Pajoro, Alice A1 - Madrigal, Pedro A1 - Muino, Jose M. A1 - Tomas Matus, Jose A1 - Jin, Jian A1 - Mecchia, Martin A. A1 - Debernardi, Juan M. A1 - Palatnik, Javier F. A1 - Balazadeh, Salma A1 - Arif, Muhammad A1 - Wellmer, Frank A1 - Krajewski, Pawel A1 - Riechmann, Jose-Luis A1 - Angenent, Gerco C. A1 - Kaufmann, Kerstin T1 - Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development JF - Genome biology : biology for the post-genomic era N2 - Background: Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood. Results: We characterized the relationship of chromatin accessibility, gene expression, and DNA binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA binding correlated with changes in gene expression, and many of the target genes could be associated with the developmental stage in which they are transcriptionally controlled. We also observe dynamic changes in chromatin accessibility during flower development. Remarkably, DNA binding of APETALA1 and SEPALLATA3 is largely independent of the accessibility status of their binding regions and it can precede increases in DNA accessibility. These results suggest that APETALA1 and SEPALLATA3 may modulate chromatin accessibility, thereby facilitating access of other transcriptional regulators to their target genes. Conclusions: Our findings indicate that different homeotic factors regulate partly overlapping, yet also distinctive sets of target genes in a partly stage-specific fashion. By combining the information from DNA-binding and gene expression data, we are able to propose models of stage-specific regulatory interactions, thereby addressing dynamics of regulatory networks throughout flower development. Furthermore, MADS-domain TFs may regulate gene expression by alternative strategies, one of which is modulation of chromatin accessibility. KW - Flower Development KW - Floral Organ KW - Floral Meristem KW - Chromatin Accessibility KW - Growth Regulate Factor Y1 - 2014 U6 - https://doi.org/10.1186/gb-2014-15-3-r41 SN - 1465-6906 SN - 1474-760X VL - 15 PB - BioMed Central CY - London ER - TY - GEN A1 - Pajoro, Alice A1 - Madrigal, Pedro A1 - Muiño, Jose M. A1 - Matus, José Tomás A1 - Jin, Jian A1 - Mecchia, Martin A. A1 - Debernardi, Juan M. A1 - Palatnik, Javier F. A1 - Balazadeh, Salma A1 - Arif, Muhammad A1 - Ó’Maoiléidigh, Diarmuid S. A1 - Wellmer, Frank A1 - Krajewski, Pawel A1 - Riechmann, José-Luis A1 - Angenent, Gerco C. A1 - Kaufmann, Kerstin T1 - Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background: Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood. Results: We characterized the relationship of chromatin accessibility, gene expression, and DNA binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA binding correlated with changes in gene expression, and many of the target genes could be associated with the developmental stage in which they are transcriptionally controlled. We also observe dynamic changes in chromatin accessibility during flower development. Remarkably, DNA binding of APETALA1 and SEPALLATA3 is largely independent of the accessibility status of their binding regions and it can precede increases in DNA accessibility. These results suggest that APETALA1 and SEPALLATA3 may modulate chromatin accessibility, thereby facilitating access of other transcriptional regulators to their target genes. Conclusions: Our findings indicate that different homeotic factors regulate partly overlapping, yet also distinctive sets of target genes in a partly stage-specific fashion. By combining the information from DNA-binding and gene expression data, we are able to propose models of stage-specific regulatory interactions, thereby addressing dynamics of regulatory networks throughout flower development. Furthermore, MADS-domain TFs may regulate gene expression by alternative strategies, one of which is modulation of chromatin accessibility. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1327 KW - flower development KW - floral organ KW - floral meristem KW - chromatin accessibility KW - growth regulate factor Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431139 SN - 1866-8372 VL - 15 ER - TY - JOUR A1 - Steinke, Martin A1 - Oskinova, Lida A1 - Hamann, Wolf-Rainer A1 - Sander, Andreas Alexander Christoph A1 - Liermann, A. A1 - Todt, Helge Tobias T1 - Analysis of the WN star WR102c, its WR nebula, and the associated cluster of massive stars in the Sickle Nebula JF - Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth N2 - Context. The massive Wolf-Rayet type star WR102c is located near the Quintuplet Cluster, one of the three massive star clusters in the Galactic centre region. Previous studies indicated that WR102c may have a dusty circumstellar nebula and is among the main ionising sources of the Sickle Nebula associated with the Quintuplet Cluster. Aims. The goals of our study are to derive the stellar parameters of WR102c from the analysis of its spectrum and to investigate its stellar and nebular environment. Methods. We obtained observations with the ESO VLT integral field spectrograph SINFONI in the K-band, extracted the stellar spectra, and analysed them by means of stellar atmosphere models. Results. Our new analysis supersedes the results previously reported for WR102c. We significantly decrease its bolometric luminosity and hydrogen content. We detect four early OB type stars close to WR102c. These stars have radial velocities similar to that of WR102c. We suggest that together with WR102c these stars belong to a distinct star cluster with a total mass of similar to 1000 M-circle dot. We identify a new WR nebula around WR102c in the SINFONI map of the di ff use Br gamma emission and in the HST Pa ff images. The Br gamma line at di ff erent locations is not significantly broadened and similar to the width of nebular emission elsewhere in the H i i region around WR102c. Conclusions. The massive star WR102c located in the Galactic centre region resides in a star cluster containing additional early-type stars. The stellar parameters of WR102c are typical for hydrogen-free WN6 stars. We identify a nebula surrounding WR102c that has a morphology similar to other nebulae around hydrogen-free WR stars, and propose that the formation of this nebula is linked to interaction of the fast stellar wind with the matter ejected at a previous evolutionary stage of WR102c. KW - stars: early-type KW - stars: individual: WR 102c KW - stars: Wolf KW - Rayet KW - Galaxy: center KW - HII regions KW - infrared: stars Y1 - 2016 U6 - https://doi.org/10.1051/0004-6361/201527692 SN - 1432-0746 VL - 588 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Grimm, Volker A1 - Augusiak, Jacqueline A1 - Focks, Andreas A1 - Frank, Beatrice M. A1 - Gabsi, Faten A1 - Johnston, Alice S. A. A1 - Liu, Chun A1 - Martin, Benjamin T. A1 - Meli, Mattia A1 - Radchuk, Viktoriia A1 - Thorbek, Pernille A1 - Railsback, Steven Floyd T1 - Towards better modelling and decision support: Documenting model development, testing, and analysis using TRACE JF - Ecological modelling : international journal on ecological modelling and engineering and systems ecolog N2 - The potential of ecological models for supporting environmental decision making is increasingly acknowledged. However, it often remains unclear whether a model is realistic and reliable enough. Good practice for developing and testing ecological models has not yet been established. Therefore, TRACE, a general framework for documenting a model's rationale, design, and testing was recently suggested. Originally TRACE was aimed at documenting good modelling practice. However, the word 'documentation' does not convey TRACE's urgency. Therefore, we re-define TRACE as a tool for planning, performing, and documenting good modelling practice. TRACE documents should provide convincing evidence that a model was thoughtfully designed, correctly implemented, thoroughly tested, well understood, and appropriately used for its intended purpose. TRACE documents link the science underlying a model to its application, thereby also linking modellers and model users, for example stakeholders, decision makers, and developers of policies. We report on first experiences in producing TRACE documents. We found that the original idea underlying TRACE was valid, but to make its use more coherent and efficient, an update of its structure and more specific guidance for its use are needed. The updated TRACE format follows the recently developed framework of model 'evaludation': the entire process of establishing model quality and credibility throughout all stages of model development, analysis, and application. TRACE thus becomes a tool for planning, documenting, and assessing model evaludation, which includes understanding the rationale behind a model and its envisaged use. We introduce the new structure and revised terminology of TRACE and provide examples. (C) 2014 Elsevier B.V. All rights reserved. KW - Standardization KW - Good modelling practice KW - Risk assessment KW - Decision support Y1 - 2014 U6 - https://doi.org/10.1016/j.ecolmodel.2014.01.018 SN - 0304-3800 SN - 1872-7026 VL - 280 SP - 129 EP - 139 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Tracy, Rosemarie A1 - Heide, Judith A1 - Wahl, Michael A1 - Triarchi-Herrmann, Vassilia A1 - Grimm, Angela A1 - Wotschack, Christiane A1 - Kulik, Sylvia A1 - Frank, Ulrike A1 - Klassert, Annegret A1 - Gagarina, Natalʹja Vladimirovna A1 - Kauschke, Christina A1 - Eicher, Iris A1 - Tsakmaki, Barbara A1 - Akkaya, Zeynep A1 - Castillo, Esmeralda A1 - Groba, Agnes A1 - Höhle, Barbara A1 - Miertsch, Barbara A1 - Hubert, Anja A1 - Sauerland, Uli A1 - Schröder, Caroline A1 - Stadie, Nicole A1 - Wittler, Marion A1 - Berendes, Karin A1 - Gottal, Stephanie A1 - Grabherr, Britta A1 - Zaps, Jennifer A1 - Ptok, Martin A1 - Hanne, Sandra A1 - Sekerina, Irina A. A1 - Vasishth, Shravan A1 - Burchert, Frank A1 - De Bleser, Ria A1 - Kleissendorf, Barbara A1 - Jaecks, Petra A1 - Stenneken, Prisca A1 - Fischer, Ivette A1 - Moedebeck, Petra ED - Heide, Judith ED - Hanne, Sandra ED - Brandt-Kobele, Oda-Christina ED - Fritzsche, Tom T1 - Spektrum Patholinguistik = Schwerpunktthema: Ein Kopf - Zwei Sprachen : Mehrsprachigkeit in Forschung und Therapie N2 - "Spektrum Patholinguistik" (Band 2) ist der Tagungsband zum 2. Herbsttreffen Patholinguistik, das der Verband für Patholinguistik (vpl) e.V. am 22.11.2008 an der Universität Potsdam veranstaltet hat. Zum Schwerpunktthema "Ein Kopf - Zwei Sprachen: Mehrsprachigkeit in Forschung und Therapie" sind die drei Hauptvorträge und vier Abstracts von Posterpräsentationen veröffentlicht. Desweiteren enthält der Tagungsband freie Beiträge, u.a. zu Satzverarbeitung und Agrammatismus, Lesestrategien und LRS, Prosodie-Entwicklung, kindlichen Aphasien, Dysphagie-Therapie sowie zu kognitiven Defiziten bei älteren Menschen. N2 - "Spektrum Patholinguistik" (vol. 2) contains the proceedings of the "2nd Herbsttreffen Patholinguistik" which was held at the University of Potsdam on November 22, 2008. Many talks and posters focused on bilingual language processing in normal and impaired speakers. The other contributions covered various topics, e.g. sentence processing and agrammatism, reading strategies and developmental dyslexia, language development, childhood aphasia, dysphagia therapy and cognitive skills in aging. T3 - Spektrum Patholinguistik - 2 KW - Patholinguistik KW - Bilingualismus KW - Mehrsprachigkeit KW - Sprachtherapie KW - Sprachförderung KW - patholinguistics KW - bilingualism KW - speech and language therapy Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30451 SN - 978-3-940793-89-8 SN - 1869-3822 SN - 1866-9433 IS - 2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Foerster, Verena A1 - Deocampo, Daniel M. A1 - Asrat, Asfawossen A1 - Günter, Christina A1 - Junginger, Annett A1 - Krämer, Kai Hauke A1 - Stroncik, Nicole A. A1 - Trauth, Martin H. T1 - Towards an understanding of climate proxy formation in the Chew Bahir basin, southern Ethiopian Rift JF - Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences N2 - Deciphering paleoclimate from lake sediments is a challenge due to the complex relationship between climate parameters and sediment composition. Here we show the links between potassium (K) concentrations in the sediments of the Chew Bahir basin in the Southern Ethiopian Rift and fluctuations in the catchment precipitation/evaporation balance. Our micro-X-ray fluorescence and X-ray diffraction results suggest that the most likely process linking climate with potassium concentrations is the authigenic illitization of smectites during episodes of higher alkalinity and salinity in the closed -basin lake, due to a drier climate. Whole-rock and clay size fraction analyses suggest that illitization of the Chew Bahir clay minerals with increasing evaporation is enhanced by octahedral Al-to-Mg substitution in the clay minerals, with the resulting layer charge increase facilitating potassium-fixation. Linking mineralogy with geochemistry shows the links between hydroclimatic control, process and formation of the Chew Bahir K patterns, in the context of well-known and widely documented eastern African climate fluctuations over the last 45,000 years. These results indicate characteristic mineral alteration patterns associated with orbitally controlled wet-dry cycles such as the African Humid Period (similar to 15-5 ka) or high-latitude controlled climate events such as the Younger Dryas (similar to 12.8-11.6 ka) chronozone. Determining the impact of authigenic mineral alteration on the Chew Bahir records enables the interpretation of the previously established pXRF-derived aridity proxy K and provides a better paleohydrological understanding of complex climate proxy formation. KW - Paleoclimatology KW - Authigenic mineral transformation KW - Potassium KW - Illitization KW - Zeolites Y1 - 2018 U6 - https://doi.org/10.1016/j.palaeo.2018.04.009 SN - 0031-0182 SN - 1872-616X VL - 501 SP - 111 EP - 123 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ennis, Meg A1 - Meere, Patrick A. A1 - Timmerman, Martin Jan A1 - Sudo, Masafumi T1 - Post-Acadian sediment recycling in the Devonian Old Red Sandstone of Southern Ireland JF - Gondwana research : international geoscience journal ; official journal of the International Association for Gondwana Research N2 - The Upper Devonian Munster Basin of southern Ireland has traditionally been viewed as a post-orogenic molasse deposit that was sourced from the Caledonides of central Ireland and subsequently deformed by the end Carboniferous Variscan orogenic event. The basin fill is composed of super-mature quartz arenite sandstone that clearly represents a second cycle of deposition. The source of this detritus is now recognized as Lower Devonian Dingle Basin red bed sequences to the north. This genetic link is based on the degree of similarity in the detrital mica chemistry in both of these units; micas plot in identical fields and define the same trends. In addition, the two sequences show increased textural and chemical maturity up-sequence and define indistinguishable Ar-40/Ar-39 age ranges for the detrital mica grains. Partial resetting of the Ar ages can be attributed to elevated heat flow in the region caused by Munster Basin extension and subsequent Variscan deformation. The combined evidence from southwest Ireland therefore points to a Caledonian or possibly Taconian primary source area that initially shed detritus into the Lower Devonian Dingle Basin which was subsequently recycled into the Upper Devonian Munster Basin following mid-Devonian Acadian basin inversion. (C) 2014 International Association for Gondwana Research. Published by Elsevier B.V. All rights reserved. KW - Caledonian KW - Acadian KW - Variscan KW - Old Red Sandstone KW - Sediment recycling Y1 - 2015 U6 - https://doi.org/10.1016/j.gr.2014.10.007 SN - 1342-937X SN - 1878-0571 VL - 28 IS - 4 SP - 1415 EP - 1433 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kuhne, Maren A1 - Dippong, Martin A1 - Flemig, Sabine A1 - Hoffmann, Katrin A1 - Petsch, Kristin A1 - Schenk, Jörg A. A1 - Kunte, Hans-Jörg A1 - Schneider, Rudolf J. T1 - Comparative characterization of mAb producing hapten-specific hybridoma cells by flow cytometric analysis and ELISA JF - Journal of immunological methods N2 - A novel method that optimizes the screening for antibody-secreting hapten-specific hybridoma cells by using flow cytometry is described. Cell clones specific for five different haptens were analyzed. We selectively double stained and analyzed fixed hybridoma cells with fluorophore-labeled haptens to demonstrate the target-selectivity, and with a fluorophore-labeled anti-mouse IgG antibody to characterize the level of surface expression of membrane-bound IgGs. ELISA measurements with the supernatants of the individual hybridoma clones revealed that antibodies from those cells, which showed the highest fluorescence intensities in the flow cytometric analysis, also displayed the highest affinities for the target antigens. The fluorescence intensity of antibody-producing cells corresponded well with the produced antibodies' affinities toward their respective antigens. Immunohistochemical staining verified the successful double labeling of the cells. Our method makes it possible to perform a high-throughput screening for hybridoma cells, which have both an adequate IgG production rate and a high target affinity. (C) 2014 Elsevier B.V. All rights reserved. KW - Immunization KW - Hapten KW - Monoclonal antibodies KW - Hybridoma KW - Flow cytometry KW - ELISA Y1 - 2014 U6 - https://doi.org/10.1016/j.jim.2014.07.004 SN - 0022-1759 SN - 1872-7905 VL - 413 SP - 45 EP - 56 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Sheriff, Ahmed A1 - Vogt, B. A1 - Baumgart, Martin A1 - Montag, C. A1 - Hollenbach, B. A1 - Schenk, Jörg A. A1 - Ulrich, J. A1 - Ellias, F. A1 - Micheel, Burkhard T1 - Intracellular capture of B7 in antigen-presenting cells reduces costimulatory activity N2 - CTLA-4 gene constructs were designed to express CTLA-4 exclusively in the endoplasmic reticulum (ER). Four different CTLA-4 gene constructs were transfected into HEK 293 (human embryonic kidney) and A20 (Balb/c mouse B lymphoma) cells. All constructs contained an ER retention signal and coded for CTLA-4 expression in the ER. One of the constructs, which contained the membrane part of CTLA-4, coded for an expression both on the cell surface and in the ER. Three of the expressed CTLA-4 types (including the ER-membrane-expressed form) caused a reduced surface expression of B7 in the A20 cells. Only constructs which allow dimerization of CTLA-4 showed this effect. It is assumed that intracellular CTLA-4 bound B7 and inhibited therefore the transport of B7 to the surface. The binding obviously caused also an enhanced degradation of the complexes because both proteins showed a low concentration in the transfected cell lines. CTLA-4-transfected and B7-reduced A20 cells showed a diminished costimulating activity upon T cells. This was demonstrated by a reduced proliferation of T cells from ovalbumin-immunized Balb/c mice, incubated with ovalbumin peptide-primed CTLA-4-transfected A20 cells. Y1 - 2003 UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-47T23XK- 8&_coverDate=02%2F21%2F2003&_alid=268969757&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6713&_sort=d&view=c&_acct=C000053886&_v e ER - TY - JOUR A1 - Jay, Raphael M. A1 - Norell, Jesper A1 - Eckert, Sebastian A1 - Hantschmann, Markus A1 - Beye, Martin A1 - Kennedy, Brian A1 - Quevedo, Wilson A1 - Schlotter, William F. A1 - Dakovski, Georgi L. A1 - Minitti, Michael P. A1 - Hoffmann, Matthias C. A1 - Mitra, Ankush A1 - Moeller, Stefan P. A1 - Nordlund, Dennis A1 - Zhang, Wenkai A1 - Liang, Huiyang W. A1 - Kunnus, Kristian A1 - Kubicek, Katharina A1 - Techert, Simone A. A1 - Lundberg, Marcus A1 - Wernet, Philippe A1 - Gaffney, Kelly A1 - Odelius, Michael A1 - Föhlisch, Alexander T1 - Disentangling Transient Charge Density and Metal-Ligand Covalency in Photoexcited Ferricyanide with Femtosecond Resonant Inelastic Soft X-ray Scattering JF - The journal of physical chemistry letters N2 - Soft X-ray spectroscopies are ideal probes of the local valence electronic structure of photocatalytically active metal sites. Here, we apply the selectivity of time resolved resonant inelastic X-ray scattering at the iron L-edge to the transient charge distribution of an optically excited charge-transfer state in aqueous ferricyanide. Through comparison to steady-state spectra and quantum chemical calculations, the coupled effects of valence-shell closing and ligand-hole creation are experimentally and theoretically disentangled and described in terms of orbital occupancy, metal-ligand covalency, and ligand field splitting, thereby extending established steady-state concepts to the excited-state domain. pi-Back-donation is found to be mainly determined by the metal site occupation, whereas the ligand hole instead influences sigma-donation. Our results demonstrate how ultrafast resonant inelastic X-ray scattering can help characterize local charge distributions around catalytic metal centers in short-lived charge-transfer excited states, as a step toward future rationalization and tailoring of photocatalytic capabilities of transition-metal complexes. Y1 - 2018 U6 - https://doi.org/10.1021/acs.jpclett.8b01429 SN - 1948-7185 VL - 9 IS - 12 SP - 3538 EP - 3543 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Dippong, Martin A1 - Carl, Peter A1 - Lenz, Christine A1 - Schenk, Jörg A. A1 - Hoffmann, Katrin A1 - Schwaar, Timm A1 - Schneider, Rudolf J. A1 - Kuhne, Maren T1 - Hapten-Specific Single-Cell Selection of Hybridoma Clones by Fluorescence-Activated Cell Sorting for the Generation of Monoclonal Antibodies JF - Analytical chemistry Y1 - 2017 U6 - https://doi.org/10.1021/acs.analchem.6b04569 SN - 0003-2700 SN - 1520-6882 VL - 89 SP - 4007 EP - 4012 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Schreck, Simon A1 - Beye, Martin A1 - Sellberg, Jonas A. A1 - McQueen, Trevor A1 - Laksmono, Hartawan A1 - Kennedy, Brian A1 - Eckert, Sebastian A1 - Schlesinger, Daniel A1 - Nordlund, Dennis A1 - Ogasawara, Hirohito A1 - Sierra, Raymond G. A1 - Segtnan, Vegard H. A1 - Kubicek, Katharina A1 - Schlotter, William F. A1 - Dakovski, Georgi L. A1 - Moeller, Stefan P. A1 - Bergmann, Uwe A1 - Techert, Simone A1 - Pettersson, Lars G. M. A1 - Wernet, Philippe A1 - Bogan, Michael J. A1 - Harada, Yoshihisa A1 - Nilsson, Anders A1 - Föhlisch, Alexander T1 - Reabsorption of soft x-ray emission at high x-ray free-electron laserfluences JF - Physical review letters N2 - We report on oxygen K-edge soft x-ray emission spectroscopy from a liquid water jet at the Linac Coherent Light Source. We observe significant changes in the spectral content when tuning over a wide range of incident x-ray fluences. In addition the total emission yield decreases at high fluences. These modifications result from reabsorption of x-ray emission by valence-excited molecules generated by the Auger cascade. Our observations have major implications for future x-ray emission studies at intense x-ray sources. We highlight the importance of the x-ray pulse length with respect to the core-hole lifetime. Y1 - 2014 U6 - https://doi.org/10.1103/PhysRevLett.113.153002 SN - 0031-9007 SN - 1079-7114 VL - 113 IS - 15 PB - American Physical Society CY - College Park ER - TY - CHAP A1 - Jacqmin, Julien A1 - Özdemir, Paker Doğu A1 - Fell Kurban, Caroline A1 - Tunç Pekkan, Zelha A1 - Koskinen, Johanna A1 - Suonpää, Maija A1 - Seng, Cheyvuth A1 - Carlon, May Kristine Jonson A1 - Gayed, John Maurice A1 - Cross, Jeffrey S. A1 - Langseth, Inger A1 - Jacobsen, Dan Yngve A1 - Haugsbakken, Halvdan A1 - Bethge, Joseph A1 - Serth, Sebastian A1 - Staubitz, Thomas A1 - Wuttke, Tobias A1 - Nordemann, Oliver A1 - Das, Partha-Pratim A1 - Meinel, Christoph A1 - Ponce, Eva A1 - Srinath, Sindhu A1 - Allegue, Laura A1 - Perach, Shai A1 - Alexandron, Giora A1 - Corti, Paola A1 - Baudo, Valeria A1 - Turró, Carlos A1 - Moura Santos, Ana A1 - Nilsson, Charlotta A1 - Maldonado-Mahauad, Jorge A1 - Valdiviezo, Javier A1 - Carvallo, Juan Pablo A1 - Samaniego-Erazo, Nicolay A1 - Poce, Antonella A1 - Re, Maria Rosaria A1 - Valente, Mara A1 - Karp Gershon, Sa’ar A1 - Ruipérez-Valiente, José A. A1 - Despujol, Ignacio A1 - Busquets, Jaime A1 - Kerr, John A1 - Lorenz, Anja A1 - Schön, Sandra A1 - Ebner, Martin A1 - Wittke, Andreas A1 - Beirne, Elaine A1 - Nic Giolla Mhichíl, Mairéad A1 - Brown, Mark A1 - Mac Lochlainn, Conchúr A1 - Topali, Paraskevi A1 - Chounta, Irene-Angelica A1 - Ortega-Arranz, Alejandro A1 - Villagrá-Sobrino, Sara L. A1 - Martínez-Monés, Alejandra A1 - Blackwell, Virginia Katherine A1 - Wiltrout, Mary Ellen A1 - Rami Gaddem, Mohamed A1 - Hernández Reyes, César Augusto A1 - Nagahama, Toru A1 - Buchem, Ilona A1 - Okatan, Ebru A1 - Khalil, Mohammad A1 - Casiraghi, Daniela A1 - Sancassani, Susanna A1 - Brambilla, Federica A1 - Mihaescu, Vlad A1 - Andone, Diana A1 - Vasiu, Radu A1 - Şahin, Muhittin A1 - Egloffstein, Marc A1 - Bothe, Max A1 - Rohloff, Tobias A1 - Schenk, Nathanael A1 - Schwerer, Florian A1 - Ifenthaler, Dirk A1 - Hense, Julia A1 - Bernd, Mike ED - Meinel, Christoph ED - Staubitz, Thomas ED - Schweiger, Stefanie ED - Friedl, Christian ED - Kiers, Janine ED - Ebner, Martin ED - Lorenz, Anja ED - Ubachs, George ED - Mongenet, Catherine ED - Ruipérez-Valiente, José A. ED - Cortes Mendez, Manoel T1 - EMOOCs 2021 N2 - From June 22 to June 24, 2021, Hasso Plattner Institute, Potsdam, hosted the seventh European MOOC Stakeholder Summit (EMOOCs 2021) together with the eighth ACM Learning@Scale Conference. Due to the COVID-19 situation, the conference was held fully online. The boost in digital education worldwide as a result of the pandemic was also one of the main topics of this year’s EMOOCs. All institutions of learning have been forced to transform and redesign their educational methods, moving from traditional models to hybrid or completely online models at scale. The learnings, derived from practical experience and research, have been explored in EMOOCs 2021 in six tracks and additional workshops, covering various aspects of this field. In this publication, we present papers from the conference’s Experience Track, the Policy Track, the Business Track, the International Track, and the Workshops. KW - e-learning KW - microcredential KW - MOOC KW - digital education KW - experience KW - online course design KW - online course creation KW - higher education Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-510300 SN - 978-3-86956-512-5 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Perez-Lopez, Raul A1 - Martin-Velazquez, Saul A1 - Sanchez-Moral, Sergio A1 - Patyniak, Magda A1 - Lopez-Gutierrez, Jose A1 - Cuezva, Soledad A1 - Lario, J. A1 - Silva, P. G. A1 - Rodriguez-Pascua, M. A. A1 - Giner-Robles, J. L. T1 - New insights on speleoseismology: The geothermal gradient and heat flow values in caves for the study of active faults JF - Quaternary international : the journal of the International Union for Quaternary Research N2 - Normally in paleoseismology, the study of the tectonic slip-rate is performed in trenches on the fault scarp, or by the estimation of fault movements from the geomorphic features. In this work, we have carried out a paleoseismic analysis of the Benis Fault, located in southeast Spain, combined with a geothermal analysis inside a deep cave related to the fault (-350 m). Thus, we have estimated the last earthquake magnitude and time of occurrence from evidence of ceiling collapse and displaced carbonate blocks inside a cave, which is developed across the fault. The magnitude was obtained from the application of the empirical relationship of the fault parameters and coseismic vertical displacement, yielding a value ranging between M 5.9 and M 6.5. Moreover, we dated this paleoearthquake by the paleontological record of a "Lynx pardinus spelaea", with an age of 65 +/- 18 ka BP. Additionally, we have measured the thermal profile of the Benis Cave (-350 m of depth), from single rock point temperature measurements during 2 years. The temperature profile shows three different parts inside the cave, the shallow heterogeneous thermal zone till 50 m depth; the homogeneous thermal zone 150 m till with constant temperature and the hetero-thermal deep zone, deeper than 150 m and till the deepest zone (350 m). Furthermore, we have estimated the Vertical Geothermal Gradient, 1.85 degrees C/100 m for the deepest zone (-150; -290 m). The temperature increases with depth, showing a reverse thermal profile in comparison with normal gradients in deep caves. Finally, we have calculated the heat flux of 0.46 mWm(2). (C) 2016 Elsevier Ltd and INQUA. All rights reserved. KW - Speleoseismology KW - Active fault KW - Cave KW - Slip-rate KW - Heat flux Y1 - 2017 U6 - https://doi.org/10.1016/j.quaint.2016.11.026 SN - 1040-6182 SN - 1873-4553 VL - 451 SP - 165 EP - 175 PB - Elsevier CY - Oxford ER - TY - BOOK A1 - Fuhrmann, Michaela A1 - Schubarth, Wilfried A1 - Schulze-Reichelt, Friederike A1 - Mauermeister, Sylvi A1 - Seidel, Andreas A1 - Hartmann, Nina A1 - Erdmann, Melinda A1 - Apostolow, Benjamin A1 - Wagner, Laura A1 - Berndt, Sarah A1 - Wippermann, Melanie A1 - Ratzlaff, Olaf A1 - Lumpe, Matthias A1 - Kirjuchina, Ljuba A1 - Rost, Sophia A1 - Zurek, Peter Paul A1 - Faaß, Marcel A1 - Schellhorn, Sebastian A1 - Frank, Mario A1 - Kreitz, Christoph A1 - Wagner, Nelli A1 - Jenneck, Julia A1 - Kleemann, Katrin A1 - Vock, Miriam A1 - Schröder, Christian A1 - Erdmann, Kathrin A1 - Koziol, Matthias A1 - Meißner, Marlen A1 - Dibiasi, Anna A1 - Unger, Martin A1 - Piskunova, Elena V. A1 - Bahmutskiy, Andrey E. A1 - Bessonova, Ekatarina A. A1 - Borovik, Ludmila K. ED - Schubarth, Wilfried ED - Mauermeister, Sylvi ED - Schulze-Reichelt, Friederike ED - Seidel, Andreas T1 - Alles auf Anfang! BT - Befunde und Perspektiven zum Studieneingang T3 - Potsdamer Beiträge zur Hochschulforschung N2 - Im Zuge der Bologna-Reform ist an Hochschulen vieles in Bewegung gekommen. Studium und Lehre sind stärker ins Blickfeld gerückt. Dabei kommt der Studieneingangsphase besondere Bedeutung zu, werden doch hier die Weichen für ein erfolgreiches Studium gestellt. Deshalb ist es verständlich, dass die Hauptanstrengungen der Hochschulen auf den Studieneingang gerichtet sind – ganz nach dem Motto: „Auf den Anfang kommt es an!“. Konsens herrscht dahingehend, dass der Studieneingang neu zu gestalten ist, doch beim „Wie?“ gibt es unterschiedliche Antworten. Zugleich wird immer deutlicher, dass eine wirksame Neugestaltung der Eingangsphase nur mit einer umfassenden Reform des Studiums gelingen kann. Ziel des vierten Bandes der Potsdamer Beiträge zur Hochschulforschung ist es, eine Zwischenbilanz der Debatte zum Studieneingang zu ziehen. Auf der Basis empirischer Studien werden unterschiedliche Perspektiven auf den Studieneingang eingenommen und Empfehlungen zur Optimierung des Studieneingangs abgeleitet. Die zahlreichen Untersuchungsergebnisse Potsdamer Forschergruppen werden durch weitere nationale sowie internationale Perspektiven ergänzt. Der Band richtet sich an alle, die sich für die Entwicklung an Hochschulen interessieren. T3 - Potsdamer Beiträge zur Hochschulforschung - 4 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-422965 SN - 978-3-86956-452-4 SN - 2192-1075 SN - 2192-1083 IS - 4 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schroetter, I. A1 - Bouche, Nicolas A1 - Wendt, Martin A1 - Contini, Thierry A1 - Finley, H. A1 - Pello, R. A1 - Bacon, Roland A1 - Cantalupo, Sebastiano A1 - Marino, Raffaella Anna A1 - Richard, J. A1 - Lilly, S. J. A1 - Schaye, Joop A1 - Soto, K. A1 - Steinmetz, Matthias A1 - Straka, Lorrie A. A1 - Wisotzki, Lutz T1 - MUSE GAS FLOW AND WIND (MEGAFLOW). I. FIRST MUSE RESULTS ON BACKGROUND QUASARS JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - The physical properties of galactic winds are one of the keys to understand galaxy formation and evolution. These properties can be constrained thanks to background quasar lines of sight (LOS) passing near star-forming galaxies (SFGs). We present the first results of the MusE GAs FLOw and Wind survey obtained from two quasar fields, which have eight Mg II absorbers of which three have rest equivalent width greater than 0.8 angstrom. With the new Multi Unit Spectroscopic Explorer (MUSE) spectrograph on the Very Large Telescope (VLT), we detect six (75%) Mg II host galaxy candidates within a radius of 30. from the quasar LOS. Out of these six galaxy-quasar pairs, from geometrical argument, one is likely probing galactic outflows, where two are classified as "ambiguous,"two are likely probing extended gaseous disks and one pair seems to be a merger. We focus on the wind-pair and constrain the outflow using a high-resolution quasar spectra from the Ultraviolet and Visual Echelle Spectrograph. Assuming the metal absorption to be due to ga;s flowing out of the detected galaxy through a cone along the minor axis, we find outflow velocities in the order of approximate to 150 km s(-1) (i.e., smaller than the escape velocity) with a loading factor, eta = M-out/SFR, of approximate to 0.7. We see evidence for an open conical flow, with a low-density inner core. In the future, MUSE will provide us with about 80 multiple galaxy-quasar pairs in two dozen fields. KW - galaxies: evolution KW - galaxies: formation KW - intergalactic medium KW - quasars: individual (SDSS J213748+001220, SDSS J215200+062516) Y1 - 2016 U6 - https://doi.org/10.3847/1538-4357/833/1/39 SN - 0004-637X SN - 1538-4357 VL - 833 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Huston, Joseph P. A1 - Kornhuber, Johannes A1 - Muehle, Christiane A1 - Japtok, Lukasz A1 - Komorowski, Mara A1 - Mattern, Claudia A1 - Reichel, Martin A1 - Gulbins, Erich A1 - Kleuser, Burkhard A1 - Topic, Bianca A1 - Silva, Maria A. De Souza A1 - Mueller, Christian P. T1 - A sphingolipid mechanism for behavioral extinction JF - Journal of neurochemistry N2 - Reward-dependent instrumental behavior must continuously be re-adjusted according to environmental conditions. Failure to adapt to changes in reward contingencies may incur psychiatric disorders like anxiety and depression. When an expected reward is omitted, behavior undergoes extinction. While extinction involves active re-learning, it is also accompanied by emotional behaviors indicative of frustration, anxiety, and despair (extinction-induced depression). Here, we report evidence for a sphingolipid mechanism in the extinction of behavior. Rapid extinction, indicating efficient re-learning, coincided with a decrease in the activity of the enzyme acid sphingomyelinase (ASM), which catalyzes turnover of sphingomyelin to ceramide, in the dorsal hippocampus of rats. The stronger the decline in ASM activity, the more rapid was the extinction. Sphingolipid-focused lipidomic analysis showed that this results in a decline of local ceramide species in the dorsal hippocampus. Ceramides shape the fluidity of lipid rafts in synaptic membranes and by that way can control neural plasticity. We also found that aging modifies activity of enzymes and ceramide levels in selective brain regions. Aging also changed how the chronic treatment with corticosterone (stress) or intranasal dopamine modified regional enzyme activity and ceramide levels, coinciding with rate of extinction. These data provide first evidence for a functional ASM-ceramide pathway in the brain involved in the extinction of learned behavior. This finding extends the known cellular mechanisms underlying behavioral plasticity to a new class of membrane-located molecules, the sphingolipids, and their regulatory enzymes, and may offer new treatment targets for extinction- and learning-related psychopathological conditions. KW - acid sphingomyelinase KW - ceramide KW - extinction KW - hippocampus KW - operant behavior KW - sphingomyelin Y1 - 2016 U6 - https://doi.org/10.1111/jnc.13537 SN - 0022-3042 SN - 1471-4159 VL - 137 SP - 589 EP - 603 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Foster, William J. A1 - Garvie, Christopher L. A1 - Weiss, Anna M. A1 - Muscente, A. Drew A1 - Aberhan, Martin A1 - Counts, John W. A1 - Martindale, Rowan C. T1 - Resilience of marine invertebrate communities during the early Cenozoic hyperthermals T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1410 KW - eocene thermal maximum KW - gulf coastal plain KW - climate-change KW - ocean acidification KW - extinction event KW - carbon-cycle KW - heat-stress KW - origination KW - ecosystems KW - diversity Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516011 SN - 1866-8372 IS - 1 ER - TY - JOUR A1 - Foster, William J. A1 - Garvie, Christopher L. A1 - Weiss, Anna M. A1 - Muscente, A. Drew A1 - Aberhan, Martin A1 - Counts, John W. A1 - Martindale, Rowan C. T1 - Resilience of marine invertebrate communities during the early Cenozoic hyperthermals JF - Scientific Reports N2 - The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated. KW - eocene thermal maximum KW - gulf coastal plain KW - climate-change KW - ocean acidification KW - extinction event KW - carbon-cycle KW - heat-stress KW - origination KW - ecosystems KW - diversity Y1 - 2020 U6 - https://doi.org/10.1038/s41598-020-58986-5 SN - 2045-2322 VL - 10 IS - 1 SP - 1 EP - 11 PB - Springer Nature CY - London ER - TY - JOUR A1 - Juma, Wanyama P. A1 - Akala, Hoseah M. A1 - Eyase, Fredrick L. A1 - Muiva, Lois M. A1 - Heydenreich, Matthias A1 - Okalebo, Faith A. A1 - Gitu, Peter M. A1 - Peter, Martin G. A1 - Walsh, Douglas S. A1 - Imbuga, Mabel A1 - Yenesew, Abiy T1 - Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea JF - Phytochemistry letters N2 - The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence. KW - Tephrosia purpurea KW - Leguminosae KW - Stem KW - Flavone KW - Terpurinflavone KW - Antiplasmodial Y1 - 2011 U6 - https://doi.org/10.1016/j.phytol.2011.02.010 SN - 1874-3900 VL - 4 IS - 2 SP - 176 EP - 178 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Leins, Johannes A. A1 - Grimm, Volker A1 - Drechsler, Martin T1 - Large-scale PVA modeling of insects in cultivated grasslands BT - the role of dispersal in mitigating the effects of management schedules under climate change JF - Ecology and evolution N2 - In many species, dispersal is decisive for survival in a changing climate. Simulation models for population dynamics under climate change thus need to account for this factor. Moreover, large numbers of species inhabiting agricultural landscapes are subject to disturbances induced by human land use. We included dispersal in the HiLEG model that we previously developed to study the interaction between climate change and agricultural land use in single populations. Here, the model was parameterized for the large marsh grasshopper (LMG) in cultivated grasslands of North Germany to analyze (1) the species development and dispersal success depending on the severity of climate change in subregions, (2) the additional effect of grassland cover on dispersal success, and (3) the role of dispersal in compensating for detrimental grassland mowing. Our model simulated population dynamics in 60-year periods (2020-2079) on a fine temporal (daily) and high spatial (250 x 250 m(2)) scale in 107 subregions, altogether encompassing a range of different grassland cover, climate change projections, and mowing schedules. We show that climate change alone would allow the LMG to thrive and expand, while grassland cover played a minor role. Some mowing schedules that were harmful to the LMG nevertheless allowed the species to moderately expand its range. Especially under minor climate change, in many subregions dispersal allowed for mowing early in the year, which is economically beneficial for farmers. More severe climate change could facilitate LMG expansion to uninhabited regions but would require suitable mowing schedules along the path. These insights can be transferred to other species, given that the LMG is considered a representative of grassland communities. For more specific predictions on the dynamics of other species affected by climate change and land use, the publicly available HiLEG model can be easily adapted to the characteristics of their life cycle. KW - bilinear interpolation KW - climate change KW - dispersal success KW - land use KW - large marsh grasshopper KW - spatially explicit model Y1 - 2022 U6 - https://doi.org/10.1002/ece3.9063 SN - 2045-7758 VL - 12 IS - 7 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Trauth, Martin H. A1 - Maslin, Mark A. A1 - Deino, Alan A1 - Strecker, Manfred T1 - Late Cenozoic Moisture History of East Africa N2 - Lake sediments in 10 Ethiopian, Kenyan, and Tanzanian rift basins suggest that there were three humid periods at 2.7 to 2.5 million years ago (Ma), 1.9 to 1.7 Ma, and 1.1 to 0.9 Ma, superimposed on the longer-term aridification of East Africa. These humid periods correlate with increased aridity in northwest and northeast Africa and with substantial global climate transitions. These episodes could have had important impacts on the speciation and dispersal of mammals and hominins, because a number of key events, such as the origin of the genus Homo and the evolution of the species Homo erectus, took place in this region during that time. Y1 - 2005 UR - http://dx.doi.org/10.1126/science.1112964 ER - TY - JOUR A1 - Trauth, Martin H. A1 - Maslin, Mark A. A1 - Deino, Alan L. A1 - Strecker, Manfred A1 - Bergner, Andreas G. N. A1 - Dühnforth, Miriam T1 - High- and low-latitude forcing of Plio-Pleistocene African climate and human evolution N2 - The late Cenozoic climate of East Africa is punctuated by episodes of short, alternating periods of extreme wetness and aridity, superimposed on a regime of subdued moisture availability exhibiting a long-term drying trend. These periods of extreme climate variability appear to correlate with maxima in the 400-thousand-year (kyr) component of the Earth's eccentricity cycle. Prior to 2.7 Ma the wet phases appear every 400 kyrs, whereas after 2.7 Ma, the wet phases appear every 800 kyrs, with periods of precessional-forced extreme climate variability at 2.7-2.5 Ma, 1.9-1.7 Ma, and 1.1-0.9 Ma before present. The last three major lake phases occur at the times of major global climatic transitions, such as the onset of Northern Hemisphere Glaciation (2.7-2.5 Ma), intensification of the Walker Circulation (1.9-1.7 Ma), and the Mid-Pleistocene Revolution (1.0-0.7 Ma). High-latitude forcing is required to compress the Intertropical Convergence Zone so that East Africa becomes locally sensitive to precessional forcing, resulting in rapid shifts from wet to dry conditions. These periods of extreme climate variability may have provided a catalyst for evolutionary change and driven key speciation and dispersal events amongst mammals and hominins in East Africa. (C) 2007 Elsevier Ltd. All rights reserved. Y1 - 2008 U6 - https://doi.org/10.1016/j.jhevol.2006.12.009 ER - TY - JOUR A1 - van Afferden, Manfred A1 - Rahman, Khaja Z. A1 - Mosig, Peter A1 - De Biase, Cecilia A1 - Thullner, Martin A1 - Oswald, Sascha A1 - Müller, Roland A. T1 - Remediation of groundwater contaminated with MTBE and benzene the potential of vertical-flow soil filter systems JF - Water research N2 - Field investigations on the treatment of MTBE and benzene from contaminated groundwater in pilot or full-scale constructed wetlands are lacking hugely. The aim of this study was to develop a biological treatment technology that can be operated in an economic, reliable and robust mode over a long period of time. Two pilot-scale vertical-flow soil filter eco-technologies, a roughing filter (RF) and a polishing filter (PF) with plants (willows), were operated independently in a single-stage configuration and coupled together in a multi-stage (RF + PF) configuration to investigate the MTBE and benzene removal performances. Both filters were loaded with groundwater from a refinery site contaminated with MTBE and benzene as the main contaminants, with a mean concentration of 2970 +/- 816 and 13,966 +/- 1998 mu g L(-1), respectively. Four different hydraulic loading rates (HLRs) with a stepwise increment of 60, 120, 240 and 480 L m(-2) d(-1) were applied over a period of 388 days in the single-stage operation. At the highest HLR of 480 L m(-2)d(-1), the mean concentrations of MTBE and benzene were found to be 550 +/- 133 and 65 +/- 123 mu g L(-1) in the effluent of the RF. In the effluent of the PP system, respective mean MTBE and benzene concentrations of 49 +/- 77 and 0.5 +/- 0.2 mu g L(-1) were obtained, which were well below the relevant MTBE and benzene limit values of 200 and 1 mu g L-1 for drinking water quality. But a dynamic fluctuation in the effluent MTBE concentration showed a lack of stability in regards to the increase in the measured values by nearly 10%, which were higher than the limit value. Therefore, both (RF + PF) filters were combined in a multi-stage configuration and the combined system proved to be more stable and effective with a highly efficient reduction of the MTBE and benzene concentrations in the effluent. Nearly 70% of MTBE and 98% of benzene were eliminated from the influent groundwater by the first vertical filter (RF) and the remaining amount was almost completely diminished (similar to 100% reduction) after passing through the second filter (PF), with a mean MTBE and benzene concentration of 5 +/- 10 and 0.6 +/- 0.2 mu g L(-1) in the final effluent. The emission rate of volatile organic compounds mass into the air from the systems was less than 1% of the inflow mass loading rate. The results obtained in this study not only demonstrate the feasibility of vertical-flow soil filter systems for treating groundwater contaminated with MTBE and benzene, but can also be considered a major step forward towards their application under full-scale conditions for commercial purposes in the oil and gas industries. KW - Benzene KW - Groundwater remediation KW - Hydraulic loading rate KW - MTBE KW - Pilot-scale constructed wetland KW - Vertical-flow soil filter KW - Willow tree Y1 - 2011 U6 - https://doi.org/10.1016/j.watres.2011.07.010 SN - 0043-1354 VL - 45 IS - 16 SP - 5063 EP - 5074 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Guerrero, Martín A. T1 - Planetary nebulae and Their Central Stars in X-rays JF - Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.–5. June 2015 N2 - Two types of X-ray sources are mostly found in planetary nebulae (PNe): point sources at their central stars and diffuse emission inside hot bubbles. Here we describe these two types of sources based on the most recent observations obtained in the framework of the Chandra Planetary Nebula Survey, ChanPlaNS, an X-ray survey targeting a volume-limited sample of PNe. Diffuse X-ray emission is found preferentially in young PNe with sharp, closed inner shells. Point sources of X-ray emission at the central stars reveal magnetically active binary companions and shock-in stellar winds. Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-88160 SP - 263 EP - 266 ER - TY - JOUR A1 - Nishikawa, Ken-Ichi A1 - Hardee, P. E. A1 - Dutan, I. A1 - Niemiec, J. A1 - Medvedev, M. A1 - Mizuno, Y. A1 - Meli, A. A1 - Sol, H. A1 - Zhang, B. A1 - Pohl, Martin A1 - Hartmann, D. H. T1 - Magnetic agnetic field generation in core-sheath jets via the kinetic Kelvin-Helmholtz instability JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - We have investigated magnetic field generation in velocity shears via the kinetic Kelvin-Helmholtz instability (kKHI) using a relativistic plasma jet core and stationary plasma sheath. Our three-dimensional particle-in-cell simulations consider plasma jet cores with Lorentz factors of 1.5, 5, and 15 for both electron-proton and electron-positron plasmas. For electron-proton plasmas, we find generation of strong large-scale DC currents and magnetic fields that extend over the entire shear surface and reach thicknesses of a few tens of electron skin depths. For electron-positron plasmas, we find generation of alternating currents and magnetic fields. Jet and sheath plasmas are accelerated across the shear surface in the strong magnetic fields generated by the kKHI. The mixing of jet and sheath plasmas generates a transverse structure similar to that produced by the Weibel instability. KW - acceleration of particles KW - magnetic fields KW - plasmas KW - radiation mechanisms: non-thermal KW - relativistic processes KW - stars: jets Y1 - 2014 U6 - https://doi.org/10.1088/0004-637X/793/1/60 SN - 0004-637X SN - 1538-4357 VL - 793 IS - 1 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Delahaye, T. A1 - Fiasson, A. A1 - Pohl, Martin A1 - Salati, P. T1 - The GeV-TeV Galactic gamma-ray diffuse emission I. Uncertainties in the predictions of the hadronic component JF - Astronomy and astrophysics : an international weekly journal N2 - Context. The Galactic gamma-ray diffuse emission is currently observed in the GeV-TeV energy range with unprecedented accuracy by the Fermi satellite. Understanding this component is crucial because it provides a background to many different signals, such as extragalactic sources or annihilating dark matter. It is timely to reinvestigate how it is calculated and to assess the various uncertainties that are likely to affect the accuracy of the predictions. Aims. The Galactic gamma-ray diffuse emission is mostly produced above a few GeV by the interactions of cosmic ray primaries impinging on the interstellar material. The theoretical error on that component is derived by exploring various potential sources of uncertainty. Particular attention is paid to cosmic ray propagation. Nuclear cross sections, the proton and helium fluxes at the Earth's position, the Galactic radial profile of supernova remnants, and the hydrogen distribution can also severely affect the signal. Methods. The propagation of cosmic ray species throughout the Galaxy is described in the framework of a semi-analytic two-zone diffusion/convection model. The gamma-ray flux is reliably and quickly determined. This allows conversion of the constraints set by the boron-to-carbon data into a theoretical uncertainty on the diffuse emission. New deconvolutions of the HI and CO sky maps are also used to get the hydrogen distribution within the Galaxy. Results. The thickness of the cosmic ray diffusive halo is found to have a significant effect on the Galactic gamma-ray diffuse emission, while the interplay between diffusion and convection has little influence on the signal. The uncertainties related to nuclear cross sections and to the primary cosmic ray fluxes at the Earth are significant. The radial distribution of supernova remnants along the Galactic plane turns out to be a key ingredient. As expected, the predictions are extremely sensitive to the spatial distribution of hydrogen within the Milky Way. Conclusions. Most of the sources of uncertainty are likely to be reduced in the near future. The stress should be put (i) on better determination of the thickness of the cosmic ray diffusive halo; and (ii) on refined observations of the radial profile of supernova remnants. KW - gamma rays: diffuse background KW - cosmic rays KW - methods: analytical KW - gamma rays: ISM Y1 - 2011 U6 - https://doi.org/10.1051/0004-6361/201116647 SN - 0004-6361 VL - 531 IS - 4 PB - EDP Sciences CY - Les Ulis ER - TY - GEN A1 - Nishikawa, K.-I. A1 - Zhang, B. A1 - Choi, E. J. A1 - Min, K. W. A1 - Niemiec, J. A1 - Medvedev, M. A1 - Hardee, P. A1 - Mizuno, Y. A1 - Nordlund, A. A1 - Frederiksen, J. A1 - Sol, H. A1 - Pohl, Martin A1 - Hartmann, D. H. A1 - Fishman, G.J. T1 - Radiation from accelerated particles in shocks T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Recent PIC simulations of relativistic electron-positron (electron-ion) jets injected into a stationary medium show that particle acceleration occurs in the shocked regions. Simulations show that the Weibel instability is responsible for generating and amplifying highly nonuniform, small-scale magnetic fields and for particle acceleration. These magnetic fields contribute to the electron’s transverse eflection behind the shock. The “jitter” radiation from deflected electrons in turbulent magnetic fields has properties different from synchrotron radiation calculated in a uniform magnetic field. This jitter radiation may be important for understanding the complex time evolution and/or spectral structure of gamma-ray bursts, relativistic jets in general, and supernova remnants. In order to calculate radiation from first principles and go beyond the standard synchrotron model, we have used PIC simulations. We present synthetic spectra to compare with the spectra obtained from Fermi observations. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 600 KW - relativistic jets KW - Weibel instability KW - magnetic field generation KW - particle acceleration KW - radiation Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-413128 SN - 1866-8372 IS - 600 SP - 371 EP - 372 ER - TY - JOUR A1 - Toala, Jesús Alberto A1 - Oskinova, Lida A1 - Hamann, Wolf-Rainer A1 - Ignace, Richard A1 - Sander, Andreas Alexander Christoph A1 - Shenar, Tomer A1 - Todt, Helge Tobias A1 - Chu, Y. -H. A1 - Guerrero, Martin A. A1 - Hainich, Rainer A1 - Torrejon, Jose Miguel T1 - On the Apparent Absence of Wolf-Rayet plus Neutron Star Systems BT - the Curious Case of WR124 JF - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters N2 - Among the different types of massive stars in advanced evolutionary stages is the enigmatic WN8h type. There are only a few Wolf-Rayet (WR) stars with this spectral type in our Galaxy. It has long been suggested that WN8h-type stars are the products of binary evolution that may harbor neutron stars (NS). One of the most intriguing WN8h stars is the runaway WR 124 surrounded by its magnificent nebula M1-67. We test the presence of an accreting NS companion in WR 124 using similar to 100 ks long observations by the Chandra X-ray observatory. The hard X-ray emission from WR 124 with a luminosity of L-X similar to 10(31) erg s(-1) is marginally detected. We use the non-local thermodynamic equilibrium stellar atmosphere code PoWR to estimate the WR wind opacity to the X-rays. The wind of a WN8-type star is effectively opaque for X-rays, hence the low X-ray luminosity of WR 124 does not rule out the presence of an embedded compact object. We suggest that, in general, high-opacity WR winds could prevent X-ray detections of embedded NS, and be an explanation for the apparent lack of WR+NS systems. KW - circumstellar matter KW - ISM: jets and outflows KW - stars: massive KW - stars: evolution KW - stars: neutron KW - stars: Wolf-Rayet Y1 - 2018 U6 - https://doi.org/10.3847/2041-8213/aaf39d SN - 2041-8205 SN - 2041-8213 VL - 869 IS - 1 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Toalá, Jesús Alberto A1 - Ramos-Larios, Gerardo A1 - Guerrero, Martin A. A1 - Todt, Helge Tobias T1 - Hidden IR structures in NGC40 BT - Signpost of an ancient born-again event JF - Monthly notices of the Royal Astronomical Society N2 - We present the analysis of infrared (IR) observations of the planetary nebula NGC40 together with spectral analysis of its [WC]-type central starHD826. Spitzer IRS observations were used to produce spectral maps centred at polycyclic aromatic hydrocarbons (PAH) bands and ionic transitions to compare their spatial distribution. The ionic lines show a clumpy distribution of material around the main cavity of NGC40, with the emission from [Ar II] being the most extended, whilst the PAHs show a rather smooth spatial distribution. Analysis of ratio maps shows the presence of a toroidal structure mainly seen in PAH emission, but also detected in a Herschel PACS 70 mu m image. We argue that the toroidal structure absorbs the UV flux from HD826, preventing the nebula to exhibit lines of high-excitation levels as suggested by previous authors. We discuss the origin of this structure and the results from the spectral analysis of HD826 under the scenario of a late thermal pulse. KW - stars: carbon KW - stars: evolution KW - stars: winds, outflows KW - ISM: molecules KW - planetary nebulae: individual: NGC40 KW - infrared: ISM Y1 - 2019 U6 - https://doi.org/10.1093/mnras/stz624 SN - 0035-8711 SN - 1365-2966 VL - 485 IS - 3 SP - 3360 EP - 3369 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - González-Galán, Ana A1 - Oskinova, Lida A1 - Popov, Sergei B. A1 - Haberl, F. A1 - Kühnel, M. A1 - Gallagher, John S. A1 - Schurch, Matthew A1 - Guerrero, Martín A. T1 - A multiwavelength study of SXP 1062, the long-period X-ray pulsar associated with a supernova remnant JF - Monthly notices of the Royal Astronomical Society N2 - SXP 1062 is a Be X-ray binary (BeXB) located in the Small Magellanic Cloud. It hosts a long-period X-ray pulsar and is likely associated with the supernova remnant MCSNR J0127−7332. In this work we present a multiwavelength view on SXP 1062 in different luminosity regimes. We consider monitoring campaigns in optical (OGLE survey) and X-ray (Swift telescope). During these campaigns a tight coincidence of X-ray and optical outbursts is observed. We interpret this as typical Type I outbursts as often detected in BeXBs at periastron passage of the neutron star (NS). To study different X-ray luminosity regimes in depth, during the source quiescence we observed it with XMM–Newton while Chandra observations followed an X-ray outburst. Nearly simultaneously with Chandra observations in X-rays, in optical the RSS/SALT telescope obtained spectra of SXP 1062. On the basis of our multiwavelength campaign we propose a simple scenario where the disc of the Be star is observed face-on, while the orbit of the NS is inclined with respect to the disc. According to the model of quasi-spherical settling accretion our estimation of the magnetic field of the pulsar in SXP 1062 does not require an extremely strong magnetic field at the present time. KW - stars: neutron KW - pulsars: individual: SXP 1062 KW - galaxies: individual: Small Magellanic Cloud KW - X-rays: binaries Y1 - 2017 U6 - https://doi.org/10.1093/mnras/stx3127 SN - 0035-8711 SN - 1365-2966 VL - 475 IS - 2 SP - 2809 EP - 2821 PB - Oxford University Press CY - Oxford ER - TY - GEN A1 - Srivastava, Abhishek A1 - Murugaiyan, Jayaseelan A1 - Garcia, Juan A. L. A1 - De Corte, Daniele A1 - Hoetzinger, Matthias A1 - Eravci, Murat A1 - Weise, Christoph A1 - Kumar, Yadhu A1 - Roesler, Uwe A1 - Hahn, Martin W. A1 - Grossart, Hans-Peter T1 - Combined Methylome, Transcriptome and Proteome Analyses Document Rapid Acclimatization of a Bacterium to Environmental Changes T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Polynucleobacter asymbioticus strain QLW-P1DMWA-1T represents a group of highly successful heterotrophic ultramicrobacteria that is frequently very abundant (up to 70% of total bacterioplankton) in freshwater habitats across all seven continents. This strain was originally isolated from a shallow Alpine pond characterized by rapid changes in water temperature and elevated UV radiation due to its location at an altitude of 1300 m. To elucidate the strain’s adjustment to fluctuating environmental conditions, we recorded changes occurring in its transcriptomic and proteomic profiles under contrasting experimental conditions by simulating thermal conditions in winter and summer as well as high UV irradiation. To analyze the potential connection between gene expression and regulation via methyl group modification of the genome, we also analyzed its methylome. The methylation pattern differed between the three treatments, pointing to its potential role in differential gene expression. An adaptive process due to evolutionary pressure in the genus was deduced by calculating the ratios of non-synonymous to synonymous substitution rates for 20 Polynucleobacter spp. genomes obtained from geographically diverse isolates. The results indicate purifying selection. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1011 KW - DNA modification KW - gene expression KW - freshwater heterotrophic bacteria KW - UV radiation KW - purifying selection Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-481993 SN - 1866-8372 IS - 1011 ER - TY - JOUR A1 - Lechleitner, Franziska A. A1 - Breitenbach, Sebastian Franz Martin A1 - Rehfeld, Kira A1 - Ridley, Harriet E. A1 - Asmerom, Yemane A1 - Prufer, Keith M. A1 - Marwan, Norbert A1 - Goswami, Bedartha A1 - Kennett, Douglas J. A1 - Aquino, Valorie V. A1 - Polyak, Victor A1 - Haug, Gerald H. A1 - Eglinton, Timothy I. A1 - Baldini, James U. L. T1 - Tropical rainfall over the last two millennia: evidence for a low-latitude hydrologic seesaw JF - Scientific reports N2 - The presence of a low-to mid-latitude interhemispheric hydrologic seesaw is apparent over orbital and glacial-interglacial timescales, but its existence over the most recent past remains unclear. Here we investigate, based on climate proxy reconstructions from both hemispheres, the inter-hemispherical phasing of the Intertropical Convergence Zone (ITCZ) and the low-to mid-latitude teleconnections in the Northern Hemisphere over the past 2000 years. A clear feature is a persistent southward shift of the ITCZ during the Little Ice Age until the beginning of the 19th Century. Strong covariation between our new composite ITCZ-stack and North Atlantic Oscillation (NAO) records reveals a tight coupling between these two synoptic weather and climate phenomena over decadal-to-centennial timescales. This relationship becomes most apparent when comparing two precisely dated, high-resolution paleorainfall records from Belize and Scotland, indicating that the low-to mid-latitude teleconnection was also active over annual-decadal timescales. It is likely a combination of external forcing, i.e., solar and volcanic, and internal feedbacks, that drives the synchronous ITCZ and NAO shifts via energy flux perturbations in the tropics. Y1 - 2017 U6 - https://doi.org/10.1038/srep45809 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Lechleitner, Franziska A. A1 - Breitenbach, Sebastian Franz Martin A1 - Cheng, Hai A1 - Plessen, Birgit A1 - Rehfeld, Kira A1 - Goswami, Bedartha A1 - Marwan, Norbert A1 - Eroglu, Deniz A1 - Adkins, Jess F. A1 - Haug, Gerald T1 - Climatic and in-cave influences on delta O-18 and delta C-13 in a stalagmite from northeastern India through the last deglaciation JF - Quaternary research : an interdisciplinary journal N2 - Northeastern (NE) India experiences extraordinarily pronounced seasonal climate, governed by the Indian summer monsoon (ISM). The vulnerability of this region to floods and droughts calls for detailed and highly resolved paleoclimate reconstructions to assess the recurrence rate and driving factors of ISM changes. We use stable oxygen and carbon isotope ratios (delta O-18 and delta C-13) from stalagmite MAW-6 from Mawmluh Cave to infer climate and environmental conditions in NE India over the last deglaciation (16-6ka). We interpret stalagmite delta O-18 as reflecting ISM strength, whereas delta C-13 appears to be driven by local hydroclimate conditions. Pronounced shifts in ISM strength over the deglaciation are apparent from the delta O-18 record, similarly to other records from monsoonal Asia. The ISM is weaker during the late glacial (LG) period and the Younger Dryas, and stronger during the BOlling-Allerod and Holocene. Local conditions inferred from the delta C-13 record appear to have changed less substantially over time, possibly related to the masking effect of changing precipitation seasonality. Time series analysis of the delta O-18 record reveals more chaotic conditions during the late glacial and higher predictability during the Holocene, likely related to the strengthening of the seasonal recurrence of the ISM with the onset of the Holocene. KW - Indian Summer Monsoon KW - stalagmite KW - oxygen isotopes KW - carbon isotopes KW - deglaciation Y1 - 2017 U6 - https://doi.org/10.1017/qua.2017.72 SN - 0033-5894 SN - 1096-0287 VL - 88 SP - 458 EP - 471 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Srivastava, Abhishek A1 - Murugaiyan, Jayaseelan A1 - Garcia, Juan A. L. A1 - De Corte, Daniele A1 - Hoetzinger, Matthias A1 - Eravci, Murat A1 - Weise, Christoph A1 - Kumar, Yadhu A1 - Roesler, Uwe A1 - Hahn, Martin W. A1 - Grossart, Hans-Peter T1 - Combined Methylome, Transcriptome and Proteome Analyses Document Rapid Acclimatization of a Bacterium to Environmental Changes JF - Frontiers in Microbiology N2 - Polynucleobacter asymbioticus strain QLW-P1DMWA-1T represents a group of highly successful heterotrophic ultramicrobacteria that is frequently very abundant (up to 70% of total bacterioplankton) in freshwater habitats across all seven continents. This strain was originally isolated from a shallow Alpine pond characterized by rapid changes in water temperature and elevated UV radiation due to its location at an altitude of 1300 m. To elucidate the strain’s adjustment to fluctuating environmental conditions, we recorded changes occurring in its transcriptomic and proteomic profiles under contrasting experimental conditions by simulating thermal conditions in winter and summer as well as high UV irradiation. To analyze the potential connection between gene expression and regulation via methyl group modification of the genome, we also analyzed its methylome. The methylation pattern differed between the three treatments, pointing to its potential role in differential gene expression. An adaptive process due to evolutionary pressure in the genus was deduced by calculating the ratios of non-synonymous to synonymous substitution rates for 20 Polynucleobacter spp. genomes obtained from geographically diverse isolates. The results indicate purifying selection. KW - DNA modification KW - gene expression KW - freshwater heterotrophic bacteria KW - UV radiation KW - purifying selection Y1 - 2020 U6 - https://doi.org/10.3389/fmicb.2020.544785 SN - 1664-302X VL - 11 PB - Frontiers Media CY - Lausanne ER - TY - INPR A1 - Wannicke, Nicola A1 - Endres, S. A1 - Engel, A. A1 - Grossart, Hans-Peter A1 - Nausch, M. A1 - Unger, J. A1 - Voss, Martin T1 - Response of nodularia spumigena to pCO(2) - Part 1: Growth, production and nitrogen cycling T2 - Biogeosciences N2 - Heterocystous cyanobacteria of the genus Nodularia form extensive blooms in the Baltic Sea and contribute substantially to the total annual primary production. Moreover, they dispense a large fraction of new nitrogen to the ecosystem when inorganic nitrogen concentration in summer is low. Thus, it is of ecological importance to know how Nodularia will react to future environmental changes, in particular to increasing carbon dioxide (CO2) concentrations and what consequences there might arise for cycling of organic matter in the Baltic Sea. Here, we determined carbon (C) and dinitrogen (N-2) fixation rates, growth, elemental stoichiometry of particulate organic matter and nitrogen turnover in batch cultures of the heterocystous cyanobacterium Nodularia spumigena under low (median 315 mu atm), mid (median 353 mu atm), and high (median 548 mu atm) CO2 concentrations. Our results demonstrate an overall stimulating effect of rising pCO(2) on C and N-2 fixation, as well as on cell growth. An increase in pCO(2) during incubation days 0 to 9 resulted in an elevation in growth rate by 84 +/- 38% (low vs. high pCO(2)) and 40 +/- 25% (mid vs. high pCO(2)), as well as in N-2 fixation by 93 +/- 35% and 38 +/- 1%, respectively. C uptake rates showed high standard deviations within treatments and in between sampling days. Nevertheless, C fixation in the high pCO(2) treatment was elevated compared to the other two treatments by 97% (high vs. low) and 44% (high vs. mid) at day 0 and day 3, but this effect diminished afterwards. Additionally, elevation in carbon to nitrogen and nitrogen to phosphorus ratios of the particulate biomass formed (POC : POP and PON : POP) was observed at high pCO(2). Our findings suggest that rising pCO(2) stimulates the growth of heterocystous diazotrophic cyanobacteria, in a similar way as reported for the non-heterocystous diazotroph Trichodesmium. Implications for biogeochemical cycling and food web dynamics, as well as ecological and socio-economical aspects in the Baltic Sea are discussed. Y1 - 2012 U6 - https://doi.org/10.5194/bg-9-2973-2012 SN - 1726-4170 VL - 9 IS - 8 SP - 2973 EP - 2988 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Annunziata, Maria Grazia A1 - Apelt, Federico A1 - Carillo, Petronia A1 - Krause, Ursula A1 - Feil, Regina A1 - Mengin, Virginie A1 - Lauxmann, Martin A. A1 - Koehl, Karin A1 - Nikoloski, Zoran A1 - Stitt, Mark A1 - Lunn, John Edward T1 - Getting back to nature: a reality check for experiments in controlled environments JF - Journal of experimental botany N2 - Irradiance from sunlight changes in a sinusoidal manner during the day, with irregular fluctuations due to clouds, and light-dark shifts at dawn and dusk are gradual. Experiments in controlled environments typically expose plants to constant irradiance during the day and abrupt light-dark transitions. To compare the effects on metabolism of sunlight versus artificial light regimes, Arabidopsis thaliana plants were grown in a naturally illuminated greenhouse around the vernal equinox, and in controlled environment chambers with a 12-h photoperiod and either constant or sinusoidal light profiles, using either white fluorescent tubes or light-emitting diodes (LEDs) tuned to a sunlight-like spectrum as the light source. Rosettes were sampled throughout a 24-h diurnal cycle for metabolite analysis. The diurnal metabolite profiles revealed that carbon and nitrogen metabolism differed significantly between sunlight and artificial light conditions. The variability of sunlight within and between days could be a factor underlying these differences. Pairwise comparisons of the artificial light sources (fluorescent versus LED) or the light profiles (constant versus sinusoidal) showed much smaller differences. The data indicate that energy-efficient LED lighting is an acceptable alternative to fluorescent lights, but results obtained from plants grown with either type of artificial lighting might not be representative of natural conditions. KW - Amino acid KW - Arabidopsis thaliana KW - controlled environment KW - LED lighting KW - visible light spectrum KW - organic acid KW - starch KW - sucrose KW - trehalose 6-phosphate Y1 - 2017 U6 - https://doi.org/10.1093/jxb/erx220 SN - 0022-0957 SN - 1460-2431 VL - 68 SP - 4463 EP - 4477 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Al-Halbouni, Djamil A1 - Holohan, Eoghan P. A1 - Taheri, Abbas A1 - Watson, Robert A. A1 - Polom, Ulrich A1 - Schoepfer, Martin P. J. A1 - Emam, Sacha A1 - Dahm, Torsten T1 - Distinct element geomechanical modelling of the formation of sinkhole clusters within large-scale karstic depressions JF - Solid earth N2 - The 2-D distinct element method (DEM) code (PFC2D_V5) is used here to simulate the evolution of subsidence-related karst landforms, such as single and clustered sinkholes, and associated larger-scale depressions. Subsurface material in the DEM model is removed progressively to produce an array of cavities; this simulates a network of subsurface groundwater conduits growing by chemical/mechanical erosion. The growth of the cavity array is coupled mechanically to the gravitationally loaded surroundings, such that cavities can grow also in part by material failure at their margins, which in the limit can produce individual collapse sinkholes. Two end-member growth scenarios of the cavity array and their impact on surface subsidence were examined in the models: (1) cavity growth at the same depth level and growth rate; (2) cavity growth at progressively deepening levels with varying growth rates. These growth scenarios are characterised by differing stress patterns across the cavity array and its overburden, which are in turn an important factor for the formation of sinkholes and uvalalike depressions. For growth scenario (1), a stable compression arch is established around the entire cavity array, hindering sinkhole collapse into individual cavities and favouring block-wise, relatively even subsidence across the whole cavity array. In contrast, for growth scenario (2), the stress system is more heterogeneous, such that local stress concentrations exist around individual cavities, leading to stress interactions and local wall/overburden fractures. Consequently, sinkhole collapses occur in individual cavities, which results in uneven, differential subsidence within a larger-scale depression. Depending on material properties of the cavity-hosting material and the overburden, the larger-scale depression forms either by sinkhole coalescence or by widespread subsidence linked geometrically to the entire cavity array. The results from models with growth scenario (2) are in close agreement with surface morphological and subsurface geophysical observations from an evaporite karst area on the eastern shore of the Dead Sea. Y1 - 2019 U6 - https://doi.org/10.5194/se-10-1219-2019 SN - 1869-9510 SN - 1869-9529 VL - 10 IS - 4 SP - 1219 EP - 1241 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Leins, Johannes A. A1 - Banitz, Thomas A1 - Grimm, Volker A1 - Drechsler, Martin T1 - High-resolution PVA along large environmental gradients to model the combined effects of climate change and land use timing BT - lessons from the large marsh grasshopper JF - Ecological modelling : international journal on ecological modelling and systems ecology N2 - Both climate change and land use regimes affect the viability of populations, but they are often studied separately. Moreover, population viability analyses (PVAs) often ignore the effects of large environmental gradients and use temporal resolutions that are too coarse to take into account that different stages of a population's life cycle may be affected differently by climate change. Here, we present the High-resolution Large Environmental Gradient (HiLEG) model and apply it in a PVA with daily resolution based on daily climate projections for Northwest Germany. We used the large marsh grasshopper (LMG) as the target species and investigated (1) the effects of climate change on the viability and spatial distribution of the species, (2) the influence of the timing of grassland mowing on the species and (3) the interaction between the effects of climate change and grassland mowing. The stageand cohort-based model was run for the spatially differentiated environmental conditions temperature and soil moisture across the whole study region. We implemented three climate change scenarios and analyzed the population dynamics for four consecutive 20-year periods. Climate change alone would lead to an expansion of the regions suitable for the LMG, as warming accelerates development and due to reduced drought stress. However, in combination with land use, the timing of mowing was crucial, as this disturbance causes a high mortality rate in the aboveground life stages. Assuming the same date of mowing throughout the region, the impact on viability varied greatly between regions due to the different climate conditions. The regional negative effects of the mowing date can be divided into five phases: (1) In early spring, the populations were largely unaffected in all the regions; (2) between late spring and early summer, they were severely affected only in warm regions; (3) in summer, all the populations were severely affected so that they could hardly survive; (4) between late summer and early autumn, they were severely affected in cold regions; and (5) in autumn, the populations were equally affected across all regions. The duration and start of each phase differed slightly depending on the climate change scenario and simulation period, but overall, they showed the same pattern. Our model can be used to identify regions of concern and devise management recommendations. The model can be adapted to the life cycle of different target species, climate projections and disturbance regimes. We show with our adaption of the HiLEG model that high-resolution PVAs and applications on large environmental gradients can be reconciled to develop conservation strategies capable of dealing with multiple stressors. KW - Climate change KW - Land use KW - Population viability analysis KW - Stage-based model KW - High resolution KW - Environmental gradients Y1 - 2020 U6 - https://doi.org/10.1016/j.ecolmodel.2020.109355 SN - 0304-3800 SN - 1872-7026 VL - 440 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Jeglinski-Mende, Melinda A. A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Rezension zu: Varma, Sashank ; Schwartz, Daniel L.: The mental representation of integers : an abstract-to-concrete shift in the understanding of mathematical concepts. - Cognition. - 121 (2011), 3. - S. 363 - 385 T2 - Frontiers in psychology KW - cognitive development KW - mental number line KW - negative numbers KW - embodied cognition KW - abstract concepts Y1 - 2018 U6 - https://doi.org/10.3389/fpsyg.2018.00209 SN - 1664-1078 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Martin, Nicolas F. A1 - Jungbluth, Valentin A1 - Nidever, David L. A1 - Bell, Eric F. A1 - Besla, Gurtina A1 - Blum, Robert D. A1 - Cioni, Maria-Rosa L. A1 - Conn, Blair C. A1 - Kaleida, Catherine C. A1 - Gallart, Carme A1 - Jin, Shoko A1 - Majewski, Steven R. A1 - Martinez-Delgado, David A1 - Monachesi, Antonela A1 - Munoz, Ricardo R. A1 - Noel, Noelia E. D. A1 - Olsen, Knut A1 - Stringfellow, Guy S. A1 - van der Marel, Roeland P. A1 - Vivas, A. Katherina A1 - Walker, Alistair R. A1 - Zaritsky, Dennis T1 - SMASH 1: A VERY FAINT GLOBULAR CLUSTER DISRUPTING IN THE OUTER REACHES OF THE LMC? JF - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters KW - globular clusters: individual: (SMASH 1) KW - Local Group KW - Magellanic Clouds Y1 - 2016 U6 - https://doi.org/10.3847/2041-8205/830/1/L10 SN - 2041-8205 SN - 2041-8213 VL - 830 SP - 92 EP - 98 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Gossner, Martin M. A1 - Lewinsohn, Thomas M. A1 - Kahl, Tiemo A1 - Grassein, Fabrice A1 - Boch, Steffen A1 - Prati, Daniel A1 - Birkhofer, Klaus A1 - Renner, Swen C. A1 - Sikorski, Johannes A1 - Wubet, Tesfaye A1 - Arndt, Hartmut A1 - Baumgartner, Vanessa A1 - Blaser, Stefan A1 - Blüthgen, Nico A1 - Börschig, Carmen A1 - Buscot, Francois A1 - Diekötter, Tim A1 - Jorge, Leonardo Re A1 - Jung, Kirsten A1 - Keyel, Alexander C. A1 - Klein, Alexandra-Maria A1 - Klemmer, Sandra A1 - Krauss, Jochen A1 - Lange, Markus A1 - Müller, Jörg A1 - Overmann, Jörg A1 - Pasalic, Esther A1 - Penone, Caterina A1 - Perovic, David J. A1 - Purschke, Oliver A1 - Schall, Peter A1 - Socher, Stephanie A. A1 - Sonnemann, Ilja A1 - Tschapka, Marco A1 - Tscharntke, Teja A1 - Türke, Manfred A1 - Venter, Paul Christiaan A1 - Weiner, Christiane N. A1 - Werner, Michael A1 - Wolters, Volkmar A1 - Wurst, Susanne A1 - Westphal, Catrin A1 - Fischer, Markus A1 - Weisser, Wolfgang W. A1 - Allan, Eric T1 - Land-use intensification causes multitrophic homogenization of grassland communities JF - Nature : the international weekly journal of science N2 - Land-use intensification is a major driver of biodiversity loss(1,2). Alongside reductions in local species diversity, biotic homogenization at larger spatial scales is of great concern for conservation. Biotic homogenization means a decrease in beta-diversity (the compositional dissimilarity between sites). Most studies have investigated losses in local (alpha)-diversity(1,3) and neglected biodiversity loss at larger spatial scales. Studies addressing beta-diversity have focused on single or a few organism groups (for example, ref. 4), and it is thus unknown whether land-use intensification homogenizes communities at different trophic levels, above-and belowground. Here we show that even moderate increases in local land-use intensity (LUI) cause biotic homogenization across microbial, plant and animal groups, both above- and belowground, and that this is largely independent of changes in alpha-diversity. We analysed a unique grassland biodiversity dataset, with abundances of more than 4,000 species belonging to 12 trophic groups. LUI, and, in particular, high mowing intensity, had consistent effects on beta-diversity across groups, causing a homogenization of soil microbial, fungal pathogen, plant and arthropod communities. These effects were nonlinear and the strongest declines in beta-diversity occurred in the transition from extensively managed to intermediate intensity grassland. LUI tended to reduce local alpha-diversity in aboveground groups, whereas the alpha-diversity increased in belowground groups. Correlations between the alpha-diversity of different groups, particularly between plants and their consumers, became weaker at high LUI. This suggests a loss of specialist species and is further evidence for biotic homogenization. The consistently negative effects of LUI on landscape-scale biodiversity underscore the high value of extensively managed grasslands for conserving multitrophic biodiversity and ecosystem service provision. Indeed, biotic homogenization rather than local diversity loss could prove to be the most substantial consequence of land-use intensification. Y1 - 2016 U6 - https://doi.org/10.1038/nature20575 SN - 0028-0836 SN - 1476-4687 VL - 540 SP - 266 EP - + PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Manning, Pete A1 - Gossner, Martin M. A1 - Bossdorf, Oliver A1 - Allan, Eric A1 - Zhang, Yuan-Ye A1 - Prati, Daniel A1 - Blüthgen, Nico A1 - Boch, Steffen A1 - Böhm, Stefan A1 - Börschig, Carmen A1 - Hölzel, Norbert A1 - Jung, Kirsten A1 - Klaus, Valentin H. A1 - Klein, Alexandra-Maria A1 - Kleinebecker, Till A1 - Krauss, Jochen A1 - Lange, Markus A1 - Müller, Jörg A1 - Pasalic, Esther A1 - Socher, Stephanie A. A1 - Tschapka, Marco A1 - Türke, Manfred A1 - Weiner, Christiane A1 - Werner, Michael A1 - Gockel, Sonja A1 - Hemp, Andreas A1 - Renner, Swen C. A1 - Wells, Konstans A1 - Buscot, Francois A1 - Kalko, Elisabeth K. V. A1 - Linsenmair, Karl Eduard A1 - Weisser, Wolfgang W. A1 - Fischer, Markus T1 - Grassland management intensification weakens the associations among the diversities of multiple plant and animal taxa JF - Ecology : a publication of the Ecological Society of America N2 - Land-use intensification is a key driver of biodiversity change. However, little is known about how it alters relationships between the diversities of different taxonomic groups, which are often correlated due to shared environmental drivers and trophic interactions. Using data from 150 grassland sites, we examined how land-use intensification (increased fertilization, higher livestock densities, and increased mowing frequency) altered correlations between the species richness of 15 plant, invertebrate, and vertebrate taxa. We found that 54% of pairwise correlations between taxonomic groups were significant and positive among all grasslands, while only one was negative. Higher land-use intensity substantially weakened these correlations(35% decrease in rand 43% fewer significant pairwise correlations at high intensity), a pattern which may emerge as a result of biodiversity declines and the breakdown of specialized relationships in these conditions. Nevertheless, some groups (Coleoptera, Heteroptera, Hymenoptera and Orthoptera) were consistently correlated with multidiversity, an aggregate measure of total biodiversity comprised of the standardized diversities of multiple taxa, at both high and lowland-use intensity. The form of intensification was also important; increased fertilization and mowing frequency typically weakened plant-plant and plant-primary consumer correlations, whereas grazing intensification did not. This may reflect decreased habitat heterogeneity under mowing and fertilization and increased habitat heterogeneity under grazing. While these results urge caution in using certain taxonomic groups to monitor impacts of agricultural management on biodiversity, they also suggest that the diversities of some groups are reasonably robust indicators of total biodiversity across a range of conditions. KW - Biodiversity indicators KW - correlation KW - fertilization KW - grassland management KW - grazing KW - land-use change KW - land-use intensity KW - mowing KW - multidiversity KW - multitrophic interactions Y1 - 2015 U6 - https://doi.org/10.1890/14-1307.1 SN - 0012-9658 SN - 1939-9170 VL - 96 IS - 6 SP - 1492 EP - 1501 PB - Wiley CY - Washington ER - TY - JOUR A1 - Kühne, Katharina A1 - Fischer, Martin H. A1 - Jeglinski-Mende, Melinda A. T1 - During the COVID-19 pandemic participants prefer settings with a face mask, no interaction and at a closer distance JF - Scientific Reports N2 - Peripersonal space is the space surrounding our body, where multisensory integration of stimuli and action execution take place. The size of peripersonal space is flexible and subject to change by various personal and situational factors. The dynamic representation of our peripersonal space modulates our spatial behaviors towards other individuals. During the COVID-19 pandemic, this spatial behavior was modified by two further factors: social distancing and wearing a face mask. Evidence from offline and online studies on the impact of a face mask on pro-social behavior is mixed. In an attempt to clarify the role of face masks as pro-social or anti-social signals, 235 observers participated in the present online study. They watched pictures of two models standing at three different distances from each other (50, 90 and 150 cm), who were either wearing a face mask or not and were either interacting by initiating a hand shake or just standing still. The observers’ task was to classify the model by gender. Our results show that observers react fastest, and therefore show least avoidance, for the shortest distances (50 and 90 cm) but only when models wear a face mask and do not interact. Thus, our results document both pro- and anti-social consequences of face masks as a result of the complex interplay between social distancing and interactive behavior. Practical implications of these findings are discussed. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-16730-1 SN - 2045-2322 VL - 12 SP - 1 EP - 12 PB - Springer Nature CY - Berlin ER - TY - JOUR A1 - Prieske, Olaf A1 - Behrens, Martin A1 - Chaabene, Helmi A1 - Granacher, Urs A1 - Maffiuletti, Nicola A. T1 - Time to differentiate postactivation "potentiation" from "performance enhancement" in the strength and conditioning community JF - Sports medicine : the world's premier sports medicine preview journal N2 - Coaches and athletes in elite sports are constantly seeking to use innovative and advanced training strategies to efficiently improve strength/power performance in already highly-trained individuals. In this regard, high-intensity conditioning contractions have become a popular means to induce acute improvements primarily in muscle contractile properties, which are supposed to translate to subsequent power performances. This performance-enhancing physiological mechanism has previously been called postactivation potentiation (PAP). However, in contrast to the traditional mechanistic understanding of PAP that is based on electrically-evoked twitch properties, an increasing number of studies used the term PAP while referring to acute performance enhancements, even if physiological measures of PAP were not directly assessed. In this current opinion article, we compare the two main approaches (i.e., mechanistic vs. performance) used in the literature to describe PAP effects. We additionally discuss potential misconceptions in the general use of the term PAP. Studies showed that mechanistic and performance-related PAP approaches have different characteristics in terms of the applied research field (basic vs. applied), effective conditioning contractions (e.g., stimulated vs. voluntary), verification (lab-based vs. field tests), effects (twitch peak force vs. maximal voluntary strength), occurrence (consistent vs. inconsistent), and time course (largest effect immediately after vs. similar to 7 min after the conditioning contraction). Moreover, cross-sectional studies revealed inconsistent and trivial-to-large-sized associations between selected measures of mechanistic (e.g., twitch peak force) vs. performance-related PAP approaches (e.g., jump height). In an attempt to avoid misconceptions related to the two different PAP approaches, we propose to use two different terms. Postactivation potentiation should only be used to indicate the increase in muscular force/torque production during an electrically-evoked twitch. In contrast, postactivation performance enhancement (PAPE) should be used to refer to the enhancement of measures of maximal strength, power, and speed following conditioning contractions. The implementation of this terminology would help to better differentiate between mechanistic and performance-related PAP approaches. This is important from a physiological point of view, but also when it comes to aggregating findings from PAP studies, e.g., in the form of meta-analyses, and translating these findings to the field of strength and conditioning. Y1 - 2020 U6 - https://doi.org/10.1007/s40279-020-01300-0 SN - 0112-1642 SN - 1179-2035 VL - 50 IS - 9 SP - 1559 EP - 1565 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Nitschke, Felix A1 - Wang, Peixiang A1 - Schmieder, Peter A1 - Girard, Jean-Marie A1 - Awrey, Donald E. A1 - Wang, Tony A1 - Israelian, Johan A1 - Zhao, XiaoChu A1 - Turnbull, Julie A1 - Heydenreich, Matthias A1 - Kleinpeter, Erich A1 - Steup, Martin A1 - Minassian, Berge A. T1 - Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy lafora disease JF - Cell metabolism N2 - Laforin or malin deficiency causes Lafora disease, characterized by altered glycogen metabolism and teenage-onset neurodegeneration with intractable and invariably fatal epilepsy. Plant starches possess small amounts of metabolically essential monophosphate esters. Glycogen contains similar phosphate amounts, which are thought to originate from a glycogen synthase error side reaction and therefore lack any specific function. Glycogen is also believed to lack monophosphates at glucosyl carbon C6, an essential phosphorylation site in plant starch metabolism. We now show that glycogen phosphorylation is not due to a glycogen synthase side reaction, that C6 is a major glycogen phosphorylation site, and that C6 monophosphates predominate near centers of glycogen molecules and positively correlate with glycogen chain lengths. Laforin or malin deficiency causes C6 hyperphosphorylation, which results in malformed long-chained glycogen that accumulates in many tissues, causing neurodegeneration in brain. Our work advances the understanding of Lafora disease pathogenesis and suggests that glycogen phosphorylation has important metabolic function. Y1 - 2013 U6 - https://doi.org/10.1016/j.cmet.2013.04.006 SN - 1550-4131 SN - 1932-7420 VL - 17 IS - 5 SP - 756 EP - 767 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Andreev, Andrei A1 - Nazarova, Larisa B. A1 - Lenz, Marlene M. A1 - Böhmer, Thomas A1 - Syrykh, Ludmila A1 - Wagner, Bernd A1 - Melles, Martin A1 - Pestryakova, Luidmila A. A1 - Herzschuh, Ulrike T1 - Late Quaternary paleoenvironmental reconstructions from sediments of Lake Emanda (Verkhoyansk Mountains, East Siberia) JF - Journal of quaternary science : JQS N2 - Continuous pollen and chironomid records from Lake Emanda (65 degrees 17'N, 135 degrees 45'E) provide new insights into the Late Quaternary environmental history of the Yana Highlands (Yakutia). Larch forest with shrubs (alders, pines, birches) dominated during the deposition of the lowermost sediments suggesting its Early Weichselian [Marine Isotope Stage (MIS) 5] age. Pollen- and chironomid-based climate reconstructions suggest July temperatures (T-July) slightly lower than modern. Gradually increasing amounts of herb pollen and cold stenotherm chironomid head capsules reflect cooler and drier environments, probably during the termination of MIS 5. T-July dropped to 8 degrees C. Mostly treeless vegetation is reconstructed during MIS 3. Tundra and steppe communities dominated during MIS 2. Shrubs became common after similar to 14.5 ka BP but herb-dominated habitats remained until the onset of the Holocene. Larch forests with shrub alder and dwarf birch dominated after the Holocene onset, ca. 11.7 ka BP. Decreasing amounts of shrub pollen during the Lateglacial are assigned to the Older Dryas and Younger Dryas with T-July similar to 7.5 degrees C. T-July increased up to 13 degrees C. Shrub stone pine was present after similar to 7.5 ka BP. The vegetation has been similar to modern since ca. 5.8 ka BP. Chironomid diversity and concentration in the sediments increased towards the present day, indicating the development of richer hydrobiological communities in response to the Holocene thermal maximum. KW - chironomids KW - environmental reconstructions KW - Late Quaternary KW - pollen Y1 - 2022 U6 - https://doi.org/10.1002/jqs.3419 SN - 0267-8179 SN - 1099-1417 VL - 37 IS - 5 SP - 884 EP - 899 PB - Wiley CY - New York, NY [u.a.] ER - TY - JOUR A1 - Rothe, Martin A1 - Zhao, Yuhang A1 - Kewes, Günter A1 - Kochovski, Zdravko A1 - Sigle, Wilfried A1 - van Aken, Peter A. A1 - Koch, Christoph A1 - Ballauff, Matthias A1 - Lu, Yan A1 - Benson, Oliver T1 - Silver nanowires with optimized silica coating as versatile plasmonic resonators JF - Scientific reports N2 - Metal nanoparticles are the most frequently used nanostructures in plasmonics. However, besides nanoparticles, metal nanowires feature several advantages for applications. Their elongation offers a larger interaction volume, their resonances can reach higher quality factors, and their mode structure provides better coupling into integrated hybrid dielectric-plasmonic circuits. It is crucial though, to control the distance of the wire to a supporting substrate, to another metal layer or to active materials with sub-nanometer precision. A dielectric coating can be utilized for distance control, but it must not degrade the plasmonic properties. In this paper, we introduce a controlled synthesis and coating approach for silver nanowires to fulfill these demands. We synthesize and characterize silver nanowires of around 70 nm in diameter. These nanowires are coated with nm-sized silica shells using a modified Stober method to achieve a homogeneous and smooth surface quality. We use transmission electron microscopy, dark-field microscopy and electron-energy loss spectroscopy to study morphology and plasmonic resonances of individual nanowires and quantify the influence of the silica coating. Thorough numerical simulations support the experimental findings showing that the coating does not deteriorate the plasmonic properties and thus introduce silver nanowires as usable building blocks for integrated hybrid plasmonic systems. Y1 - 2019 U6 - https://doi.org/10.1038/s41598-019-40380-5 SN - 2045-2322 VL - 9 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Dallmeyer, A. A1 - Claussen, Martin A1 - Wang, Y. A1 - Herzschuh, Ulrike T1 - Spatial variability of Holocene changes in the annual precipitation pattern a model-data synthesis for the Asian monsoon region JF - Climate dynamics : observational, theoretical and computational research on the climate system N2 - This study provides a detailed analysis of the mid-Holocene to present-day precipitation change in the Asian monsoon region. We compare for the first time results of high resolution climate model simulations with a standardised set of mid-Holocene moisture reconstructions. Changes in the simulated summer monsoon characteristics (onset, withdrawal, length and associated rainfall) and the mechanisms causing the Holocene precipitation changes are investigated. According to the model, most parts of the Indian subcontinent received more precipitation (up to 5 mm/day) at mid-Holocene than at present-day. This is related to a stronger Indian summer monsoon accompanied by an intensified vertically integrated moisture flux convergence. The East Asian monsoon region exhibits local inhomogeneities in the simulated annual precipitation signal. The sign of this signal depends on the balance of decreased pre-monsoon and increased monsoon precipitation at mid-Holocene compared to present-day. Hence, rainfall changes in the East Asian monsoon domain are not solely associated with modifications in the summer monsoon circulation but also depend on changes in the mid-latitudinal westerly wind system that dominates the circulation during the pre-monsoon season. The proxy-based climate reconstructions confirm the regional dissimilarities in the annual precipitation signal and agree well with the model results. Our results highlight the importance of including the pre-monsoon season in climate studies of the Asian monsoon system and point out the complex response of this system to the Holocene insolation forcing. The comparison with a coarse climate model simulation reveals that this complex response can only be resolved in high resolution simulations. KW - Asian monsoon KW - Holocene KW - Precipitation KW - Climate modelling KW - Moisture reconstructions Y1 - 2013 U6 - https://doi.org/10.1007/s00382-012-1550-6 SN - 0930-7575 SN - 1432-0894 VL - 40 IS - 11-12 SP - 2919 EP - 2936 PB - Springer CY - New York ER - TY - GEN A1 - Fischer, Martin H. A1 - Winter, Bodo A1 - Felisatti, Arianna A1 - Myachykov, Andriy A1 - Jeglinski-Mende, Melinda A. A1 - Shaki, Samuel T1 - More Instructions Make Fewer Subtractions T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Research on problem solving offers insights into how humans process task-related information and which strategies they use (Newell and Simon, 1972; Öllinger et al., 2014). Problem solving can be defined as the search for possible changes in one's mind (Kahneman, 2003). In a recent study, Adams et al. (2021) assessed whether the predominant problem solving strategy when making changes involves adding or subtracting elements. In order to do this, they used several examples of simple problems, such as editing text or making visual patterns symmetrical, either in naturalistic settings or on-line. The essence of the authors' findings is a strong preference to add rather than subtract elements across a diverse range of problems, including the stabilizing of artifacts, creating symmetrical patterns, or editing texts. More specifically, they succeeded in demonstrating that “participants were less likely to identify advantageous subtractive changes when the task did not (vs. did) cue them to consider subtraction, when they had only one opportunity (vs. several) to recognize the shortcomings of an additive search strategy or when they were under a higher (vs. lower) cognitive load” (Adams et al., 2021, p. 258). Addition and subtraction are generally defined as de-contextualized mathematical operations using abstract symbols (Russell, 1903/1938). Nevertheless, understanding of both symbols and operations is informed by everyday activities, such as making or breaking objects (Lakoff and Núñez, 2000; Fischer and Shaki, 2018). The universal attribution of “addition bias” or “subtraction neglect” to problem solving activities is perhaps a convenient shorthand but it overlooks influential framing effects beyond those already acknowledged in the report and the accompanying commentary (Meyvis and Yoon, 2021). Most importantly, while Adams et al.'s study addresses an important issue, their very method of verbally instructing participants, together with lack of control over several known biases, might render their findings less than conclusive. Below, we discuss our concerns that emerged from the identified biases, namely those regarding the instructions and the experimental materials. Moreover, we refer to research from mathematical cognition that provides new insights into Adams et al.'s findings. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 763 KW - problem solving KW - addition KW - subtraction KW - cognitive bias KW - SNARC Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-550086 SN - 1866-8364 VL - 12 SP - 1 EP - 3 PB - Universitätsverlag Potsdam CY - Potsdam ER -