TY  - JOUR
A1  - Zirafi, Onofrio
A1  - Kim, Kyeong-Ae
A1  - Ständker, Ludger
A1  - Mohr, Katharina B.
A1  - Sauter, Daniel
A1  - Heigele, Anke
A1  - Kluge, Silvia F.
A1  - Wiercinska, Eliza
A1  - Chudziak, Doreen
A1  - Richter, Rudolf
A1  - Möpps, Barbara
A1  - Gierschik, Peter
A1  - Vas, Virag
A1  - Geiger, Hartmut
A1  - Lamla, Markus
A1  - Weil, Tanja
A1  - Burster, Timo
A1  - Zgraja, Andreas
A1  - Daubeuf, Francois
A1  - Frossard, Nelly
A1  - Hachet-Haas, Muriel
A1  - Heunisch, Fabian
A1  - Reichetzeder, Christoph
A1  - Galzi, Jean-Luc
A1  - Perez-Castells, Javier
A1  - Canales-Mayordomo, Angeles
A1  - Jimenez-Barbero, Jesus
A1  - Gimenez-Gallego, Guillermo
A1  - Schneider, Marion
A1  - Shorter, James
A1  - Telenti, Amalio
A1  - Hocher, Berthold
A1  - Forssmann, Wolf-Georg
A1  - Bonig, Halvard
A1  - Kirchhoff, Frank
A1  - Münch, Jan
T1  - Discovery and Characterization of an Endogenous CXCR4 Antagonist
JF  - Cell reports
N2  - CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a blood-derived peptide library for inhibitors of CXCR4-tropic HIV-1 strains. This approach identified a 16 amino acid fragment of serum albumin as an effective and highly specific CXCR4 antagonist. The endogenous peptide, termed EPI-X4, is evolutionarily conserved and generated from the highly abundant albumin precursor by pH-regulated proteases. EPI-X4 forms an unusual lasso-like structure and antagonizes CXCL12-induced tumor cell migration, mobilizes stem cells, and suppresses inflammatory responses in mice. Furthermore, the peptide is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker. Our results identify EPI-X4 as a key regulator of CXCR4 signaling and introduce proteolysis of an abundant precursor protein as an alternative concept for chemokine receptor regulation.
Y1  - 2015
U6  - https://doi.org/10.1016/j.celrep.2015.03.061
SN  - 2211-1247
VL  - 11
IS  - 5
SP  - 737
EP  - 747
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - BOOK
A1  - Albers, Marion
A1  - Appel, Ivo
A1  - Bauer, Hartmut
A1  - von Bogdandy, Armin
A1  - Britz, Gabriele
A1  - Bumke, Wolfgang
A1  - Fehling, Michael
A1  - Gusy, Christoph
A1  - Hermes, Georg
A1  - Hill, Hermann
A1  - Hoffmann-Riem, Wolfgang
A1  - Holznagel, Bernd
A1  - Köck, Wolfgang
A1  - Ladeur, Karl-Heinz
A1  - Michael, Lothar
A1  - Pitschas, Rainer
A1  - Röhl, Hans Christian
A1  - Rossen-Stahlfeld, Helge
A1  - Sachs, Michael
A1  - Sachsofsky, Ute
A1  - Schmidt-Aßmann, Eberhard
A1  - Schneider, Jens-Peter
A1  - Vesting, Thomas
ED  - Hoffmann-Riem, Wolfgang
ED  - Schmidt-Aßmann, Eberhard
ED  - Voßkuhle, Andreas
T1  - Grundlagen des Verwaltungsrechts : Bd. II Informationsordnung, Verwaltungsverfahren, Handlungsformen
Y1  - 2008
SN  - 978-3-406-54718-8
VL  - 2
PB  - Beck
CY  - München
ER  -