TY  - JOUR
A1  - Szymanski, Kolja V.
A1  - Tönnies, Mario
A1  - Becher, Anne
A1  - Fatykhova, Diana
A1  - N'Guessan, Philippe D.
A1  - Gutbier, Birgitt
A1  - Klauschen, Frederick
A1  - Neuschäfer-Rube, Frank
A1  - Schneider, Paul
A1  - Rückert, Jens
A1  - Neudecker, Jens
A1  - Bauer, Torsten T.
A1  - Dalhoff, Klaus
A1  - Droemann, Daniel
A1  - Gruber, Achim D.
A1  - Kershaw, Olivia
A1  - Temmesfeld-Wollbrueck, Bettina
A1  - Suttorp, Norbert
A1  - Hippenstiel, Stefan
A1  - Hocke, Andreas C.
T1  - Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue
JF  - The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
N2  - The majority of cases of community-acquired pneumonia are caused by Streptococcus pneumoniae and most studies on pneumococcal host interaction are based on cell culture or animal experiments. Thus, little is known about infections in human lung tissue.
 Cyclooxygenase-2 and its metabolites play an important regulatory role in lung inflammation. Therefore, we established a pneumococcal infection model on human lung tissue demonstrating mitogen-activated protein kinase (MAPK)-dependent induction of cyclooxygenase-2 and its related metabolites.
 In addition to alveolar macrophages and the vascular endothelium, cyclooxygenase-2 was upregulated in alveolar type II but not type I epithelial cells, which was confirmed in lungs of patients suffering from acute pneumonia. Moreover, we demonstrated the expression profile of all four E prostanoid receptors at the mRNA level and showed functionality of the E prostanoid(4) receptor by cyclic adenosine monophosphate production. Additionally, in comparison to previous studies, cyclooxygenase-2/prostaglandin E-2 related pro- and anti-inflammatory mediator regulation was partly confirmed in human lung tissue after pneumococcal infection.
 Overall, cell type-specific and MAPK-dependent cyclooxygenase-2 expression and prostaglandin E-2 formation in human lung tissue may play an important role in the early phase of pneumococcal infections.
KW  - Alveolar epithelial cells
KW  - cytokines
KW  - inflammation
KW  - lung infection
KW  - pneumonia
KW  - prostaglandins
Y1  - 2012
U6  - https://doi.org/10.1183/09031936.00186911
SN  - 0903-1936
VL  - 40
IS  - 6
SP  - 1458
EP  - 1467
PB  - European Respiratory Society
CY  - Sheffield
ER  - 
TY  - JOUR
A1  - Wolff, Martin
A1  - Zhang-Haagen, Bo
A1  - Decker, Christina
A1  - Barz, Bogdan
A1  - Schneider, Mario
A1  - Biehl, Ralf
A1  - Radulescu, Aurel
A1  - Strodel, Birgit
A1  - Willbold, Dieter
A1  - Nagel-Steger, Luitgard
T1  - A beta 42 pentamers/hexamers are the smallest detectable oligomers in solution
JF  - Scientific reports
Y1  - 2017
U6  - https://doi.org/10.1038/s41598-017-02370-3
SN  - 2045-2322
VL  - 7
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Abeysekara, A. U.
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Brose, Robert
A1  - Buchovecky, M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Chromey, A. J.
A1  - Connolly, M. P.
A1  - Cui, Wei
A1  - Daniel, M. K.
A1  - Falcone, A.
A1  - Feng, Qi
A1  - Finley, John P.
A1  - Fortson, L.
A1  - Furniss, Amy
A1  - Huetten, M.
A1  - Hanna, David
A1  - Hervet, O.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Humensky, T. B.
A1  - Johnson, Caitlin A.
A1  - Kaaret, Philip
A1  - Kar, P.
A1  - Kertzman, M.
A1  - Kieda, David
A1  - Krause, M.
A1  - Krennrich, F.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Mukherjee, Reshmi
A1  - Ong, R. A.
A1  - Otte, Adam Nepomuk
A1  - Park, Nahee
A1  - Petrashyk, A.
A1  - Pohl, Martin
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, Gregory T.
A1  - Roache, E.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, Marcos
A1  - Sembroski, G. H.
A1  - Shahinyan, Karlen
A1  - Sushch, I.
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Williamson, T. J.
A1  - Zitzer, B.
A1  - Abdollahi, S.
A1  - Ajello, Marco
A1  - Baldini, Luca
A1  - Barbiellini, G.
A1  - Bastieri, Denis
A1  - Bellazzini, Ronaldo
A1  - Berenji, B.
A1  - Bissaldi, Elisabetta
A1  - Blandford, R. D.
A1  - Bonino, R.
A1  - Bottacini, E.
A1  - Brandt, Terri J.
A1  - Bruel, P.
A1  - Buehler, R.
A1  - Cameron, R. A.
A1  - Caputo, R.
A1  - Caraveo, P. A.
A1  - Castro, D.
A1  - Cavazzuti, E.
A1  - Charles, Eric
A1  - Chiaro, G.
A1  - Ciprini, S.
A1  - Cohen-Tanugi, Johann
A1  - Costantin, D.
A1  - Cutini, S.
A1  - de Palma, F.
A1  - Di Lalla, N.
A1  - Di Mauro, M.
A1  - Di Venere, L.
A1  - Dominguez, A.
A1  - Favuzzi, C.
A1  - Fegan, S. J.
A1  - Franckowiak, Anna
A1  - Fukazawa, Yasushi
A1  - Funk, Stefan
A1  - Fusco, Piergiorgio
A1  - Gargano, Fabio
A1  - Gasparrini, Dario
A1  - Giglietto, Nicola
A1  - Giordano, F.
A1  - Giroletti, Marcello
A1  - Green, D.
A1  - Grenier, I. A.
A1  - Guillemot, L.
A1  - Guiriec, Sylvain
A1  - Hays, Elizabeth
A1  - Hewitt, John W.
A1  - Horan, D.
A1  - Johannesson, G.
A1  - Kensei, S.
A1  - Kuss, M.
A1  - Larsson, Stefan
A1  - Latronico, L.
A1  - Lemoine-Goumard, Marianne
A1  - Li, J.
A1  - Longo, Francesco
A1  - Loparco, Francesco
A1  - Lovellette, M. N.
A1  - Lubrano, Pasquale
A1  - Magill, Jeffrey D.
A1  - Maldera, Simone
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J. E.
A1  - Michelson, P. F.
A1  - Mitthumsiri, W.
A1  - Mizuno, Tsunefumi
A1  - Monzani, Maria Elena
A1  - Morselli, Aldo
A1  - Moskalenko, Igor V.
A1  - Negro, M.
A1  - Nuss, E.
A1  - Ojha, R.
A1  - Omodei, Nicola
A1  - Orienti, M.
A1  - Orlando, E.
A1  - Palatiello, M.
A1  - Paliya, Vaidehi S.
A1  - Paneque, D.
A1  - Perkins, Jeremy S.
A1  - Persic, M.
A1  - Pesce-Rollins, Melissa
A1  - Petrosian, Vahe'
A1  - Piron, F.
A1  - Porter, Troy A.
A1  - Principe, G.
A1  - Raino, S.
A1  - Rando, Riccardo
A1  - Rani, B.
A1  - Razzano, Massimilano
A1  - Razzaque, Soebur
A1  - Reimer, A.
A1  - Reimer, Olaf
A1  - Reposeur, T.
A1  - Sgro, C.
A1  - Siskind, E. J.
A1  - Spandre, Gloria
A1  - Spinelli, P.
A1  - Suson, D. J.
A1  - Tajima, Hiroyasu
A1  - Thayer, J. B.
A1  - Thompson, David J.
A1  - Torres, Diego F.
A1  - Tosti, Gino
A1  - Troja, Eleonora
A1  - Valverde, J.
A1  - Vianello, Giacomo
A1  - Vogel, M.
A1  - Wood, K.
A1  - Yassine, M.
A1  - Alfaro, R.
A1  - Alvarez, C.
A1  - Alvarez, J. D.
A1  - Arceo, R.
A1  - Arteaga-Velazquez, J. C.
A1  - Rojas, D. Avila
A1  - Ayala Solares, H. A.
A1  - Becerril, A.
A1  - Belmont-Moreno, E.
A1  - BenZvi, S. Y.
A1  - Bernal, A.
A1  - Braun, J.
A1  - Brisbois, C.
A1  - Caballero-Mora, K. S.
A1  - Capistran, T.
A1  - Carraminana, A.
A1  - Casanova, Sabrina
A1  - Castillo, M.
A1  - Cotti, U.
A1  - Cotzomi, J.
A1  - Coutino de Leon, S.
A1  - De Leon, C.
A1  - De la Fuente, E.
A1  - Dichiara, S.
A1  - Dingus, B. L.
A1  - DuVernois, M. A.
A1  - Diaz-Velez, J. C.
A1  - Engel, K.
A1  - Enriquez-Rivera, O.
A1  - Fiorino, D. W.
A1  - Fleischhack, H.
A1  - Fraija, N.
A1  - Garcia-Gonzalez, J. A.
A1  - Garfias, F.
A1  - Gonzalez Munoz, A.
A1  - Gonzalez, M. M.
A1  - Goodman, J. A.
A1  - Hampel-Arias, Z.
A1  - Harding, J. P.
A1  - Hernandez, S.
A1  - Hernandez-Almada, A.
A1  - Hona, B.
A1  - Hueyotl-Zahuantitla, F.
A1  - Hui, C. M.
A1  - Huntemeyer, P.
A1  - Iriarte, A.
A1  - Jardin-Blicq, A.
A1  - Joshi, V.
A1  - Kaufmann, S.
A1  - Lara, A.
A1  - Lauer, R. J.
A1  - Lee, W. H.
A1  - Lennarz, D.
A1  - Leon Vargas, H.
A1  - Linnemann, J. T.
A1  - Longinotti, A. L.
A1  - Luis-Raya, G.
A1  - Luna-Garcia, R.
A1  - Lopez-Coto, R.
A1  - Malone, K.
A1  - Marinelli, S. S.
A1  - Martinez, O.
A1  - Martinez-Castellanos, I.
A1  - Martinez-Castro, J.
A1  - Martinez-Huerta, H.
A1  - Matthews, J. A.
A1  - Miranda-Romagnoli, P.
A1  - Moreno, E.
A1  - Mostafa, M.
A1  - Nayerhoda, A.
A1  - Nellen, L.
A1  - Newbold, M.
A1  - Nisa, M. U.
A1  - Noriega-Papaqui, R.
A1  - Pelayo, R.
A1  - Pretz, J.
A1  - Perez-Perez, E. G.
A1  - Ren, Z.
A1  - Rho, C. D.
A1  - Riviere, C.
A1  - Rosa-Gonzalez, D.
A1  - Rosenberg, M.
A1  - Ruiz-Velasco, E.
A1  - Salazar, H.
A1  - Greus, F. Salesa
A1  - Sandoval, A.
A1  - Schneider, M.
A1  - Arroyo, M. Seglar
A1  - Sinnis, G.
A1  - Smith, A. J.
A1  - Springer, R. W.
A1  - Surajbali, P.
A1  - Taboada, Ignacio
A1  - Tibolla, O.
A1  - Tollefson, K.
A1  - Torres, I.
A1  - Ukwatta, Tilan N.
A1  - Villasenor, L.
A1  - Weisgarber, T.
A1  - Westerhoff, Stefan
A1  - Wisher, I. G.
A1  - Wood, J.
A1  - Yapici, Tolga
A1  - Yodh, G.
A1  - Zepeda, A.
A1  - Zhou, H.
T1  - VERITAS and Fermi-LAT Observations of TeV Gamma-Ray Sources Discovered by HAWC in the 2HWC Catalog
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - The High Altitude Water Cherenkov (HAWC) collaboration recently published their 2HWC catalog, listing 39 very high energy (VHE; >100 GeV) gamma-ray sources based on 507 days of observation. Among these, 19 sources are not associated with previously known teraelectronvolt (TeV) gamma-ray sources. We have studied 14 of these sources without known counterparts with VERITAS and Fermi-LAT. VERITAS detected weak gamma-ray emission in the 1 TeV-30 TeV band in the region of DA 495, a pulsar wind nebula coinciding with 2HWC J1953+294, confirming the discovery of the source by HAWC. We did not find any counterpart for the selected 14 new HAWC sources from our analysis of Fermi-LAT data for energies higher than 10 GeV. During the search, we detected gigaelectronvolt (GeV) gamma-ray emission coincident with a known TeV pulsar wind nebula, SNR G54.1+0.3 (VER J1930+188), and a 2HWC source, 2HWC J1930+188. The fluxes for isolated, steady sources in the 2HWC catalog are generally in good agreement with those measured by imaging atmospheric Cherenkov telescopes. However, the VERITAS fluxes for SNR G54.1+0.3, DA 495, and TeV J2032+4130 are lower than those measured by HAWC, and several new HAWC sources are not detected by VERITAS. This is likely due to a change in spectral shape, source extension, or the influence of diffuse emission in the source region.
KW  - gamma rays: general
Y1  - 2018
U6  - https://doi.org/10.3847/1538-4357/aade4e
SN  - 0004-637X
SN  - 1538-4357
VL  - 866
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  -