TY  - JOUR
A1  - Actis, M.
A1  - Agnetta, G.
A1  - Aharonian, Felix A.
A1  - Akhperjanian, A. G.
A1  - Aleksic, J.
A1  - Aliu, E.
A1  - Allan, D.
A1  - Allekotte, I.
A1  - Antico, F.
A1  - Antonelli, L. A.
A1  - Antoranz, P.
A1  - Aravantinos, A.
A1  - Arlen, T.
A1  - Arnaldi, H.
A1  - Artmann, S.
A1  - Asano, K.
A1  - Asorey, H. G.
A1  - Baehr, J.
A1  - Bais, A.
A1  - Baixeras, C.
A1  - Bajtlik, S.
A1  - Balis, D.
A1  - Bamba, A.
A1  - Barbier, C.
A1  - Barcelo, M.
A1  - Barnacka, Anna
A1  - Barnstedt, Jürgen
A1  - de Almeida, U. Barres
A1  - Barrio, J. A.
A1  - Basso, S.
A1  - Bastieri, D.
A1  - Bauer, C.
A1  - Becerra Gonzalez, J.
A1  - Becherini, Yvonne
A1  - Bechtol, K. C.
A1  - Becker, J.
A1  - Beckmann, Volker
A1  - Bednarek, W.
A1  - Behera, B.
A1  - Beilicke, M.
A1  - Belluso, M.
A1  - Benallou, M.
A1  - Benbow, W.
A1  - Berdugo, J.
A1  - Berger, K.
A1  - Bernardino, T.
A1  - Bernlöhr, K.
A1  - Biland, A.
A1  - Billotta, S.
A1  - Bird, T.
A1  - Birsin, E.
A1  - Bissaldi, E.
A1  - Blake, S.
A1  - Blanch Bigas, O.
A1  - Bobkov, A. A.
A1  - Bogacz, L.
A1  - Bogdan, M.
A1  - Boisson, Catherine
A1  - Boix Gargallo, J.
A1  - Bolmont, J.
A1  - Bonanno, G.
A1  - Bonardi, A.
A1  - Bonev, T.
A1  - Borkowski, Janett
A1  - Botner, O.
A1  - Bottani, A.
A1  - Bourgeat, M.
A1  - Boutonnet, C.
A1  - Bouvier, A.
A1  - Brau-Nogue, S.
A1  - Braun, I.
A1  - Bretz, T.
A1  - Briggs, M. S.
A1  - Brun, Pierre
A1  - Brunetti, L.
A1  - Buckley, H.
A1  - Bugaev, V.
A1  - Buehler, R.
A1  - Bulik, Tomasz
A1  - Busetto, G.
A1  - Buson, S.
A1  - Byrum, K.
A1  - Cailles, M.
A1  - Cameron, R. A.
A1  - Canestrari, R.
A1  - Cantu, S.
A1  - Carmona, E.
A1  - Carosi, A.
A1  - Carr, John
A1  - Carton, P. H.
A1  - Casiraghi, M.
A1  - Castarede, H.
A1  - Catalano, O.
A1  - Cavazzani, S.
A1  - Cazaux, S.
A1  - Cerruti, B.
A1  - Cerruti, M.
A1  - Chadwick, M.
A1  - Chiang, J.
A1  - Chikawa, M.
A1  - Cieslar, M.
A1  - Ciesielska, M.
A1  - Cillis, A. N.
A1  - Clerc, C.
A1  - Colin, P.
A1  - Colome, J.
A1  - Compin, M.
A1  - Conconi, P.
A1  - Connaughton, V.
A1  - Conrad, Jan
A1  - Contreras, J. L.
A1  - Coppi, P.
A1  - Corlier, M.
A1  - Corona, P.
A1  - Corpace, O.
A1  - Corti, D.
A1  - Cortina, J.
A1  - Costantini, H.
A1  - Cotter, G.
A1  - Courty, B.
A1  - Couturier, S.
A1  - Covino, S.
A1  - Croston, J.
A1  - Cusumano, G.
A1  - Daniel, M. K.
A1  - Dazzi, F.
A1  - Deangelis, A.
A1  - de Cea del Pozo, E.
A1  - Dal Pino, E. M. de Gouveia
A1  - de Jager, O.
A1  - de la Calle Perez, I.
A1  - De La Vega, G.
A1  - De Lotto, B.
A1  - de Naurois, M.
A1  - Wilhelmi, E. de Ona
A1  - de Souza, V.
A1  - Decerprit, B.
A1  - Deil, C.
A1  - Delagnes, E.
A1  - Deleglise, G.
A1  - Delgado, C.
A1  - Dettlaff, T.
A1  - Di Paolo, A.
A1  - Di Pierro, F.
A1  - Diaz, C.
A1  - Dick, J.
A1  - Dickinson, H.
A1  - Digel, S. W.
A1  - Dimitrov, D.
A1  - Disset, G.
A1  - Djannati-Ataï, A.
A1  - Doert, M.
A1  - Domainko, W.
A1  - Dorner, D.
A1  - Doro, M.
A1  - Dournaux, J. -L.
A1  - Dravins, D.
A1  - Drury, L.
A1  - Dubois, F.
A1  - Dubois, R.
A1  - Dubus, G.
A1  - Dufour, C.
A1  - Durand, D.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edy, E.
A1  - Egberts, Kathrin
A1  - Eleftheriadis, C.
A1  - Elles, S.
A1  - Emmanoulopoulos, D.
A1  - Enomoto, R.
A1  - Ernenwein, J. -P.
A1  - Errando, M.
A1  - Etchegoyen, A.
A1  - Falcone, A. D.
A1  - Farakos, K.
A1  - Farnier, C.
A1  - Federici, S.
A1  - Feinstein, F.
A1  - Ferenc, D.
A1  - Fillin-Martino, E.
A1  - Fink, D.
A1  - Finley, C.
A1  - Finley, J. P.
A1  - Firpo, R.
A1  - Florin, D.
A1  - Foehr, C.
A1  - Fokitis, E.
A1  - Font, Ll.
A1  - Fontaine, G.
A1  - Fontana, A.
A1  - Foerster, A.
A1  - Fortson, L.
A1  - Fouque, N.
A1  - Fransson, C.
A1  - Fraser, G. W.
A1  - Fresnillo, L.
A1  - Fruck, C.
A1  - Fujita, Y.
A1  - Fukazawa, Y.
A1  - Funk, S.
A1  - Gaebele, W.
A1  - Gabici, S.
A1  - Gadola, A.
A1  - Galante, N.
A1  - Gallant, Y.
A1  - Garcia, B.
A1  - Garcia Lopez, R. J.
A1  - Garrido, D.
A1  - Garrido, L.
A1  - Gascon, D.
A1  - Gasq, C.
A1  - Gaug, M.
A1  - Gaweda, J.
A1  - Geffroy, N.
A1  - Ghag, C.
A1  - Ghedina, A.
A1  - Ghigo, M.
A1  - Gianakaki, E.
A1  - Giarrusso, S.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Giro, E.
A1  - Giubilato, P.
A1  - Glanzman, T.
A1  - Glicenstein, J. -F.
A1  - Gochna, M.
A1  - Golev, V.
A1  - Gomez Berisso, M.
A1  - Gonzalez, A.
A1  - Gonzalez, F.
A1  - Granena, F.
A1  - Graciani, R.
A1  - Granot, J.
A1  - Gredig, R.
A1  - Green, A.
A1  - Greenshaw, T.
A1  - Grimm, O.
A1  - Grube, J.
A1  - Grudzinska, M.
A1  - Grygorczuk, J.
A1  - Guarino, V.
A1  - Guglielmi, L.
A1  - Guilloux, F.
A1  - Gunji, S.
A1  - Gyuk, G.
A1  - Hadasch, D.
A1  - Haefner, D.
A1  - Hagiwara, R.
A1  - Hahn, J.
A1  - Hallgren, A.
A1  - Hara, S.
A1  - Hardcastle, M. J.
A1  - Hassan, T.
A1  - Haubold, T.
A1  - Hauser, M.
A1  - Hayashida, M.
A1  - Heller, R.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Herrero, A.
A1  - Hinton, James Anthony
A1  - Hoffmann, D.
A1  - Hofmann, W.
A1  - Hofverberg, P.
A1  - Horns, D.
A1  - Hrupec, D.
A1  - Huan, H.
A1  - Huber, B.
A1  - Huet, J. -M.
A1  - Hughes, G.
A1  - Hultquist, K.
A1  - Humensky, T. B.
A1  - Huppert, J. -F.
A1  - Ibarra, A.
A1  - Illa, J. M.
A1  - Ingjald, J.
A1  - Inoue, S.
A1  - Inoue, Y.
A1  - Ioka, K.
A1  - Jablonski, C.
A1  - Jacholkowska, A.
A1  - Janiak, M.
A1  - Jean, P.
A1  - Jensen, H.
A1  - Jogler, T.
A1  - Jung, I.
A1  - Kaaret, P.
A1  - Kabuki, S.
A1  - Kakuwa, J.
A1  - Kalkuhl, C.
A1  - Kankanyan, R.
A1  - Kapala, M.
A1  - Karastergiou, A.
A1  - Karczewski, M.
A1  - Karkar, S.
A1  - Karlsson, N.
A1  - Kasperek, J.
A1  - Katagiri, H.
A1  - Katarzynski, K.
A1  - Kawanaka, N.
A1  - Kedziora, B.
A1  - Kendziorra, E.
A1  - Khelifi, B.
A1  - Kieda, D.
A1  - Kifune, T.
A1  - Kihm, T.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Knapp, J.
A1  - Knappy, A. R.
A1  - Kneiske, T.
A1  - Knoedlseder, J.
A1  - Koeck, F.
A1  - Kodani, K.
A1  - Kohri, K.
A1  - Kokkotas, K.
A1  - Komin, N.
A1  - Konopelko, A.
A1  - Kosack, K.
A1  - Kossakowski, R.
A1  - Kostka, P.
A1  - Kotula, J.
A1  - Kowal, G.
A1  - Koziol, J.
A1  - Kraehenbuehl, T.
A1  - Krause, J.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Kretzschmann, A.
A1  - Kubo, H.
A1  - Kudryavtsev, V. A.
A1  - Kushida, J.
A1  - La Barbera, N.
A1  - La Parola, V.
A1  - La Rosa, G.
A1  - Lopez, A.
A1  - Lamanna, G.
A1  - Laporte, P.
A1  - Lavalley, C.
A1  - Le Flour, T.
A1  - Le Padellec, A.
A1  - Lenain, J. -P.
A1  - Lessio, L.
A1  - Lieunard, B.
A1  - Lindfors, E.
A1  - Liolios, A.
A1  - Lohse, T.
A1  - Lombardi, S.
A1  - Lopatin, A.
A1  - Lorenz, E.
A1  - Lubinski, P.
A1  - Luz, O.
A1  - Lyard, E.
A1  - Maccarone, M. C.
A1  - Maccarone, T.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - Maltezos, S.
A1  - Malkiewicz, P.
A1  - Mana, C.
A1  - Manalaysay, A.
A1  - Maneva, G.
A1  - Mangano, A.
A1  - Manigot, P.
A1  - Marin, J.
A1  - Mariotti, M.
A1  - Markoff, S.
A1  - Martinez, G.
A1  - Martinez, M.
A1  - Mastichiadis, A.
A1  - Matsumoto, H.
A1  - Mattiazzo, S.
A1  - Mazin, D.
A1  - McComb, T. J. L.
A1  - McCubbin, N.
A1  - McHardy, I.
A1  - Medina, C.
A1  - Melkumyan, D.
A1  - Mendes, A.
A1  - Mertsch, P.
A1  - Meucci, M.
A1  - Michalowski, J.
A1  - Micolon, P.
A1  - Mineo, T.
A1  - Mirabal, N.
A1  - Mirabel, F.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Mizuno, T.
A1  - Moal, B.
A1  - Moderski, R.
A1  - Molinari, E.
A1  - Monteiro, I.
A1  - Moralejo, A.
A1  - Morello, C.
A1  - Mori, K.
A1  - Motta, G.
A1  - Mottez, F.
A1  - Moulin, Emmanuel
A1  - Mukherjee, R.
A1  - Munar, P.
A1  - Muraishi, H.
A1  - Murase, K.
A1  - Murphy, A. Stj.
A1  - Nagataki, S.
A1  - Naito, T.
A1  - Nakamori, T.
A1  - Nakayama, K.
A1  - Naumann, C. L.
A1  - Naumann, D.
A1  - Nayman, P.
A1  - Nedbal, D.
A1  - Niedzwiecki, A.
A1  - Niemiec, J.
A1  - Nikolaidis, A.
A1  - Nishijima, K.
A1  - Nolan, S. J.
A1  - Nowak, N.
A1  - O'Brien, P. T.
A1  - Ochoa, I.
A1  - Ohira, Y.
A1  - Ohishi, M.
A1  - Ohka, H.
A1  - Okumura, A.
A1  - Olivetto, C.
A1  - Ong, R. A.
A1  - Orito, R.
A1  - Orr, M.
A1  - Osborne, J. P.
A1  - Ostrowski, M.
A1  - Otero, L.
A1  - Otte, A. N.
A1  - Ovcharov, E.
A1  - Oya, I.
A1  - Ozieblo, A.
A1  - Paiano, S.
A1  - Pallota, J.
A1  - Panazol, J. L.
A1  - Paneque, D.
A1  - Panter, M.
A1  - Paoletti, R.
A1  - Papyan, G.
A1  - Paredes, J. M.
A1  - Pareschi, G.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pedaletti, G.
A1  - Pepato, A.
A1  - Persic, M.
A1  - Petrucci, P. O.
A1  - Peyaud, B.
A1  - Piechocki, W.
A1  - Pita, S.
A1  - Pivato, G.
A1  - Platos, L.
A1  - Platzer, R.
A1  - Pogosyan, L.
A1  - Pohl, Martin
A1  - Pojmanski, G.
A1  - Ponz, J. D.
A1  - Potter, W.
A1  - Prandini, E.
A1  - Preece, R.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quel, E.
A1  - Quirrenbach, A.
A1  - Rajda, P.
A1  - Rando, R.
A1  - Rataj, M.
A1  - Raue, M.
A1  - Reimann, C.
A1  - Reimann, O.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - Renner, S.
A1  - Reymond, J. -M.
A1  - Rhode, W.
A1  - Ribo, M.
A1  - Ribordy, M.
A1  - Rico, J.
A1  - Rieger, F.
A1  - Ringegni, P.
A1  - Ripken, J.
A1  - Ristori, P.
A1  - Rivoire, S.
A1  - Rob, L.
A1  - Rodriguez, S.
A1  - Roeser, U.
A1  - Romano, Patrizia
A1  - Romero, G. E.
A1  - Rosier-Lees, S.
A1  - Rovero, A. C.
A1  - Roy, F.
A1  - Royer, S.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Ruppel, J.
A1  - Russo, F.
A1  - Ryde, F.
A1  - Sacco, B.
A1  - Saggion, A.
A1  - Sahakian, V.
A1  - Saito, K.
A1  - Saito, T.
A1  - Sakaki, N.
A1  - Salazar, E.
A1  - Salini, A.
A1  - Sanchez, F.
A1  - Sanchez Conde, M. A.
A1  - Santangelo, A.
A1  - Santos, E. M.
A1  - Sanuy, A.
A1  - Sapozhnikov, L.
A1  - Sarkar, S.
A1  - Scalzotto, V.
A1  - Scapin, V.
A1  - Scarcioffolo, M.
A1  - Schanz, T.
A1  - Schlenstedt, S.
A1  - Schlickeiser, R.
A1  - Schmidt, T.
A1  - Schmoll, J.
A1  - Schroedter, M.
A1  - Schultz, C.
A1  - Schultze, J.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwarzburg, S.
A1  - Schweizer, T.
A1  - Seiradakis, J.
A1  - Selmane, S.
A1  - Seweryn, K.
A1  - Shayduk, M.
A1  - Shellard, R. C.
A1  - Shibata, T.
A1  - Sikora, M.
A1  - Silk, J.
A1  - Sillanpaa, A.
A1  - Sitarek, J.
A1  - Skole, C.
A1  - Smith, N.
A1  - Sobczynska, D.
A1  - Sofo Haro, M.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spiga, D.
A1  - Spyrou, S.
A1  - Stamatescu, V.
A1  - Stamerra, A.
A1  - Starling, R. L. C.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Steiner, S.
A1  - Stergioulas, N.
A1  - Sternberger, R.
A1  - Stinzing, F.
A1  - Stodulski, M.
A1  - Straumann, U.
A1  - Suarez, A.
A1  - Suchenek, M.
A1  - Sugawara, R.
A1  - Sulanke, K. H.
A1  - Sun, S.
A1  - Supanitsky, A. D.
A1  - Sutcliffe, P.
A1  - Szanecki, M.
A1  - Szepieniec, T.
A1  - Szostek, A.
A1  - Szymkowiak, A.
A1  - Tagliaferri, G.
A1  - Tajima, H.
A1  - Takahashi, H.
A1  - Takahashi, K.
A1  - Takalo, L.
A1  - Takami, H.
A1  - Talbot, R. G.
A1  - Tam, P. H.
A1  - Tanaka, M.
A1  - Tanimori, T.
A1  - Tavani, M.
A1  - Tavernet, J. -P.
A1  - Tchernin, C.
A1  - Tejedor, L. A.
A1  - Telezhinsky, Igor O.
A1  - Temnikov, P.
A1  - Tenzer, C.
A1  - Terada, Y.
A1  - Terrier, R.
A1  - Teshima, M.
A1  - Testa, V.
A1  - Tibaldo, L.
A1  - Tibolla, O.
A1  - Tluczykont, M.
A1  - Peixoto, C. J. Todero
A1  - Tokanai, F.
A1  - Tokarz, M.
A1  - Toma, K.
A1  - Torres, D. F.
A1  - Tosti, G.
A1  - Totani, T.
A1  - Toussenel, F.
A1  - Vallania, P.
A1  - Vallejo, G.
A1  - van der Walt, J.
A1  - van Eldik, C.
A1  - Vandenbroucke, J.
A1  - Vankov, H.
A1  - Vasileiadis, G.
A1  - Vassiliev, V. V.
A1  - Vegas, I.
A1  - Venter, L.
A1  - Vercellone, S.
A1  - Veyssiere, C.
A1  - Vialle, J. P.
A1  - Videla, M.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Vlahakis, N.
A1  - Vlahos, L.
A1  - Vogler, P.
A1  - Vollhardt, A.
A1  - Volpe, F.
A1  - Von Gunten, H. P.
A1  - Vorobiov, S.
A1  - Wagner, S.
A1  - Wagner, R. M.
A1  - Wagner, B.
A1  - Wakely, S. P.
A1  - Walter, P.
A1  - Walter, R.
A1  - Warwick, R.
A1  - Wawer, P.
A1  - Wawrzaszek, R.
A1  - Webb, N.
A1  - Wegner, P.
A1  - Weinstein, A.
A1  - Weitzel, Q.
A1  - Welsing, R.
A1  - Wetteskind, H.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Wilkinson, M. I.
A1  - Williams, D. A.
A1  - Winde, M.
A1  - Wischnewski, R.
A1  - Wisniewski, L.
A1  - Wolczko, A.
A1  - Wood, M.
A1  - Xiong, Q.
A1  - Yamamoto, T.
A1  - Yamaoka, K.
A1  - Yamazaki, R.
A1  - Yanagita, S.
A1  - Yoffo, B.
A1  - Yonetani, M.
A1  - Yoshida, A.
A1  - Yoshida, T.
A1  - Yoshikoshi, T.
A1  - Zabalza, V.
A1  - Zagdanski, A.
A1  - Zajczyk, A.
A1  - Zdziarski, A.
A1  - Zech, Alraune
A1  - Zietara, K.
A1  - Ziolkowski, P.
A1  - Zitelli, V.
A1  - Zychowski, P.
T1  - Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy
JF  - Experimental astronomy : an international journal on astronomical instrumentation and data analysis
N2  - Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.
KW  - Ground based gamma ray astronomy
KW  - Next generation Cherenkov telescopes
KW  - Design concepts
Y1  - 2011
U6  - https://doi.org/10.1007/s10686-011-9247-0
SN  - 0922-6435
SN  - 1572-9508
VL  - 32
IS  - 3
SP  - 193
EP  - 316
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - INPR
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A1  - Zech, Alraune
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T1  - Introducing the CTA concept
T2  - Astroparticle physics
N2  - The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.
KW  - TeV gamma-ray astronomy
KW  - Air showers
KW  - Cherenkov Telescopes
Y1  - 2013
U6  - https://doi.org/10.1016/j.astropartphys.2013.01.007
SN  - 0927-6505
SN  - 1873-2852
VL  - 43
IS  - 2
SP  - 3
EP  - 18
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
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A1  - Backes, M.
A1  - Balazs, C.
A1  - Balzer, A.
A1  - Bamba, Aya
A1  - Barkov, Maxim
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A1  - Beshley, V.
A1  - Bigongiari, C.
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A1  - Chaty, Sylvain
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A1  - Chudoba, J.
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A1  - Colafrancesco, S.
A1  - Conforti, V.
A1  - Contreras, J. L.
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A1  - Daniel, M.
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A1  - Lopez, R. de los Reyes
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A1  - De Palma, F.
A1  - Del Santo, M.
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A1  - Fedorova, E.
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A1  - Nagataki, Shigehiro
A1  - Nagayoshi, T.
A1  - Naito, T.
A1  - Nakajima, D.
A1  - Nakamori, T.
A1  - Nemmen, R.
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A1  - Nikolajuk, M.
A1  - Nishijima, K.
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A1  - Porcelli, A.
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A1  - Temnikov, P.
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A1  - Vandenbroucke, Justin
A1  - Vassiliev, V.
A1  - Vecchi, M.
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A1  - Vergani, S.
A1  - Vigorito, C.
A1  - Vorobiov, S.
A1  - Vrastil, M.
A1  - Vazquez Acosta, M. L.
A1  - Wagner, S. J.
A1  - Wagner, R.
A1  - Wakely, S. P.
A1  - Walter, R.
A1  - Ward, J. E.
A1  - Watson, J. J.
A1  - Weinstein, A.
A1  - White, M.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Wilcox, P.
A1  - Williams, D. A.
A1  - Wischnewski, R.
A1  - Wojcik, P.
A1  - Yamamoto, T.
A1  - Yamamoto, H.
A1  - Yamazaki, Ryo
A1  - Yanagita, S.
A1  - Yang, L.
A1  - Yoshida, T.
A1  - Yoshida, M.
A1  - Yoshiike, S.
A1  - Yoshikoshi, T.
A1  - Zacharias, M.
A1  - Zampieri, L.
A1  - Zanin, R.
A1  - Zavrtanik, M.
A1  - Zavrtanik, D.
A1  - Zdziarski, A.
A1  - Zech, Alraune
A1  - Zechlin, Hannes
A1  - Zhdanov, V.
A1  - Ziegler, A.
A1  - Zorn, J.
T1  - Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7-3946
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX J1713.7-3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very high energy (VHE) gamma rays. Special attention is paid to exploring possible spatial (anti) correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H I emission. We present a series of simulated images of RX J1713.7-3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the nonthermal X-ray emission observed by XMM-Newton, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H I observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic versus leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator.
KW  - cosmic rays
KW  - gamma rays: ISM
KW  - ISM: individual objects (RX J1713.7-3946, G347.3-0.5)
Y1  - 2017
U6  - https://doi.org/10.3847/1538-4357/aa6d67
SN  - 0004-637X
SN  - 1538-4357
VL  - 840
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Ahnen, M. L.
A1  - Ansoldi, S.
A1  - Antonelli, L. A.
A1  - Arcaro, C.
A1  - Babic, A.
A1  - Banerjee, B.
A1  - Bangale, P.
A1  - Barres de Almeida, U.
A1  - Barrio, J. A.
A1  - Gonzalez, J. Becerra
A1  - Bednarek, W.
A1  - Bernardini, E.
A1  - Berti, A.
A1  - Bhattacharyya, W.
A1  - Blanch, O.
A1  - Bonnoli, G.
A1  - Carosi, R.
A1  - Carosi, A.
A1  - Chatterjee, A.
A1  - Colak, S. M.
A1  - Colin, P.
A1  - Colombo, E.
A1  - Contreras, J. L.
A1  - Cortina, J.
A1  - Covino, S.
A1  - Cumani, P.
A1  - Da Vela, P.
A1  - Dazzi, F.
A1  - De Angelis, A.
A1  - De Lotto, B.
A1  - Delfino, M.
A1  - Delgado, Jose Miguel Martins
A1  - Di Pierro, F.
A1  - Doert, M.
A1  - Dominguez, A.
A1  - Prester, D. Dominis
A1  - Doro, M.
A1  - Glawion, D. Eisenacher
A1  - Engelkemeier, M.
A1  - Ramazani, V. Fallah
A1  - Fernandez-Barral, A.
A1  - Fidalgo, D.
A1  - Fonseca, M. V.
A1  - Font, L.
A1  - Fruck, C.
A1  - Galindo, D.
A1  - Lopez, R. J. Garcia
A1  - Garczarczyk, M.
A1  - Gaug, M.
A1  - Giammaria, P.
A1  - Godinovic, N.
A1  - Gora, D.
A1  - Guberman, D.
A1  - Hadasch, D.
A1  - Hahn, A.
A1  - Hassan, T.
A1  - Hayashida, M.
A1  - Herrera, J.
A1  - Hose, J.
A1  - Hrupec, D.
A1  - Ishio, K.
A1  - Konno, Y.
A1  - Kubo, H.
A1  - Kushida, J.
A1  - Kuvezdic, D.
A1  - Lelas, D.
A1  - Lindfors, E.
A1  - Lombardi, S.
A1  - Longo, F.
A1  - Lopez, M.
A1  - Maggio, C.
A1  - Majumdar, P.
A1  - Makariev, M.
A1  - Maneva, G.
A1  - Manganaro, M.
A1  - Maraschi, L.
A1  - Mariotti, M.
A1  - Martinez, M.
A1  - Mazin, D.
A1  - Menzel, U.
A1  - Minev, M.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Moralejo, A.
A1  - Moreno, V.
A1  - Moretti, E.
A1  - Nagayoshi, T.
A1  - Neustroev, V.
A1  - Niedzwiecki, A.
A1  - Nievas Rosillo, M.
A1  - Nigro, C.
A1  - Nilsson, K.
A1  - Ninci, D.
A1  - Nishijima, K.
A1  - Noda, K.
A1  - Nogues, L.
A1  - Paiano, S.
A1  - Palacio, J.
A1  - Paneque, D.
A1  - Paoletti, R.
A1  - Paredes, J. M.
A1  - Pedaletti, G.
A1  - Peresano, M.
A1  - Perri, L.
A1  - Persic, M.
A1  - Moroni, P. G. Prada
A1  - Prandini, E.
A1  - Puljak, I.
A1  - Garcia, J. R.
A1  - Reichardt, I.
A1  - Ribo, M.
A1  - Rico, J.
A1  - Righi, C.
A1  - Rugliancich, A.
A1  - Saito, T.
A1  - Satalecka, K.
A1  - Schroeder, S.
A1  - Schweizer, T.
A1  - Shore, S. N.
A1  - Sitarek, J.
A1  - Snidaric, I.
A1  - Sobczynska, D.
A1  - Stamerra, A.
A1  - Strzys, M.
A1  - Suric, T.
A1  - Takalo, L.
A1  - Tavecchio, F.
A1  - Temnikov, P.
A1  - Terzic, T.
A1  - Teshima, M.
A1  - Torres-Alba, N.
A1  - Treves, A.
A1  - Tsujimoto, S.
A1  - Vanzo, G.
A1  - Vazquez Acosta, M.
A1  - Vovk, I.
A1  - Ward, J. E.
A1  - Will, M.
A1  - Zaric, D.
A1  - Arbet-Engels, A.
A1  - Baack, D.
A1  - Balbo, M.
A1  - Biland, A.
A1  - Blank, M.
A1  - Bretz, T.
A1  - Bruegge, K.
A1  - Bulinski, M.
A1  - Buss, J.
A1  - Dmytriiev, A.
A1  - Dorner, D.
A1  - Einecke, S.
A1  - Elsaesser, D.
A1  - Herbst, T.
A1  - Hildebrand, D.
A1  - Kortmann, L.
A1  - Linhoff, L.
A1  - Mahlke, M.
A1  - Mannheim, K.
A1  - Mueller, S. A.
A1  - Neise, D.
A1  - Neronov, A.
A1  - Noethe, M.
A1  - Oberkirch, J.
A1  - Paravac, A.
A1  - Rhode, W.
A1  - Schleicher, B.
A1  - Schulz, F.
A1  - Sedlaczek, K.
A1  - Shukla, A.
A1  - Sliusar, V.
A1  - Walter, R.
A1  - Archer, A.
A1  - Benbow, W.
A1  - Bird, R.
A1  - Brose, Robert
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Christiansen, J. L.
A1  - Cui, W.
A1  - Daniel, M. K.
A1  - Falcone, A.
A1  - Feng, Q.
A1  - Finley, J. P.
A1  - Gillanders, G. H.
A1  - Gueta, O.
A1  - Hanna, D.
A1  - Hervet, O.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Huetten, M.
A1  - Humensky, T. B.
A1  - Johnson, C. A.
A1  - Kaaret, P.
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krause, M.
A1  - Krennrich, F.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - Maier, G.
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Petrashyk, A.
A1  - Pichel, A.
A1  - Pohl, Martin
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, G. T.
A1  - Roache, E.
A1  - Rovero, A. C.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, K.
A1  - Sushch, Iurii
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhel, A.
A1  - Williams, D. A.
A1  - Williamson, T. J.
A1  - Zitzer, B.
A1  - Perri, M.
A1  - Verrecchia, F.
A1  - Leto, C.
A1  - Villata, M.
A1  - Raiteri, C. M.
A1  - Jorstad, S. G.
A1  - Larionov, V. M.
A1  - Blinov, D. A.
A1  - Grishina, T. S.
A1  - Kopatskaya, E. N.
A1  - Larionova, E. G.
A1  - Nikiforova, A. A.
A1  - Morozova, D. A.
A1  - Troitskaya, Yu. V.
A1  - Troitsky, I. S.
A1  - Kurtanidze, O. M.
A1  - Nikolashvili, M. G.
A1  - Kurtanidze, S. O.
A1  - Kimeridze, G. N.
A1  - Chigladze, R. A.
A1  - Strigachev, A.
A1  - Sadun, A. C.
T1  - Extreme HBL behavior of Markarian 501 during 2012
JF  - Astronomy and astrophysics : an international weekly journal / European Southern Observatory (ESO)
N2  - Aims. We aim to characterize the multiwavelength emission from Markarian 501 (Mrk 501), quantify the energy-dependent variability, study the potential multiband correlations, and describe the temporal evolution of the broadband emission within leptonic theoretical scenarios. Methods. We organized a multiwavelength campaign to take place between March and July of 2012. Excellent temporal coverage was obtained with more than 25 instruments, including the MAGIC, FACT and VERITAS Cherenkov telescopes, the instruments on board the Swift and Fermi spacecraft, and the telescopes operated by the GASP-WEBT collaboration. Results. Mrk 501 showed a very high energy (VHE) gamma-ray flux above 0.2 TeV of similar to 0.5 times the Crab Nebula flux (CU) for most of the campaign. The highest activity occurred on 2012 June 9, when the VHE flux was similar to 3 CU, and the peak of the high-energy spectral component was found to be at similar to 2 TeV. Both the X-ray and VHE gamma-ray spectral slopes were measured to be extremely hard, with spectral indices <2 during most of the observing campaign, regardless of the X-ray and VHE flux. This study reports the hardest Mrk 501 VHE spectra measured to date. The fractional variability was found to increase with energy, with the highest variability occurring at VHE. Using the complete data set, we found correlation between the X-ray and VHE bands; however, if the June 9 flare is excluded, the correlation disappears (significance <3 sigma) despite the existence of substantial variability in the X-ray and VHE bands throughout the campaign. Conclusions. The unprecedentedly hard X-ray and VHE spectra measured imply that their low- and high-energy components peaked above 5 keV and 0.5 TeV, respectively, during a large fraction of the observing campaign, and hence that Mrk 501 behaved like an extreme high-frequency-peaked blazar (EHBL) throughout the 2012 observing season. This suggests that being an EHBL may not be a permanent characteristic of a blazar, but rather a state which may change over time. The data set acquired shows that the broadband spectral energy distribution (SED) of Mrk 501, and its transient evolution, is very complex, requiring, within the framework of synchrotron self-Compton (SSC) models, various emission regions for a satisfactory description. Nevertheless the one-zone SSC scenario can successfully describe the segments of the SED where most energy is emitted, with a significant correlation between the electron energy density and the VHE gamma-ray activity, suggesting that most of the variability may be explained by the injection of high-energy electrons. The one-zone SSC scenario used reproduces the behavior seen between the measured X-ray and VHE gamma-ray fluxes, and predicts that the correlation becomes stronger with increasing energy of the X-rays.
KW  - astroparticle physics
KW  - acceleration of particles
KW  - radiation mechanisms: non-thermal
KW  - BL Lacertae objects: general
KW  - BL Lacertae objects: individual: Mrk501
Y1  - 2018
U6  - https://doi.org/10.1051/0004-6361/201833704
SN  - 1432-0746
VL  - 620
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - De Angelis, A.
A1  - Tatischeff, V.
A1  - Grenier, I. A.
A1  - McEnery, J.
A1  - Mallamaci, Manuela
A1  - Tavani, M.
A1  - Oberlack, U.
A1  - Hanlon, L.
A1  - Walter, R.
A1  - Argan, A.
A1  - Von Ballmoos, P.
A1  - Bulgarelli, A.
A1  - Bykov, A.
A1  - Hernanz, M.
A1  - Kanbach, G.
A1  - Kuvvetli, I.
A1  - Pearce, M.
A1  - Zdziarski, A.
A1  - Conrad, J.
A1  - Ghisellini, G.
A1  - Harding, A.
A1  - Isern, J.
A1  - Leising, M.
A1  - Longo, F.
A1  - Madejski, G.
A1  - Martinez, M.
A1  - Mazziotta, Mario Nicola
A1  - Paredes, J. M.
A1  - Pohl, Martin
A1  - Rando, R.
A1  - Razzano, M.
A1  - Aboudan, A.
A1  - Ackermann, M.
A1  - Addazi, A.
A1  - Ajello, M.
A1  - Albertus, C.
A1  - Alvarez, J. M.
A1  - Ambrosi, G.
A1  - Anton, S.
A1  - Antonelli, L. A.
A1  - Babic, A.
A1  - Baibussinov, B.
A1  - Balbom, M.
A1  - Baldini, L.
A1  - Balman, S.
A1  - Bambi, C.
A1  - Barres de Almeida, U.
A1  - Barrio, J. A.
A1  - Bartels, R.
A1  - Bastieri, D.
A1  - Bednarek, W.
A1  - Bernard, D.
A1  - Bernardini, E.
A1  - Bernasconi, T.
A1  - Bertucci, B.
A1  - Biland, A.
A1  - Bissaldi, E.
A1  - Boettcher, M.
A1  - Bonvicini, V.
A1  - Bosch-Ramon, V.
A1  - Bottacini, E.
A1  - Bozhilov, V.
A1  - Bretz, T.
A1  - Branchesi, M.
A1  - Brdar, V.
A1  - Bringmann, T.
A1  - Brogna, A.
A1  - Jorgensen, C. Budtz
A1  - Busetto, G.
A1  - Buson, S.
A1  - Busso, M.
A1  - Caccianiga, A.
A1  - Camera, S.
A1  - Campana, R.
A1  - Caraveo, P.
A1  - Cardillo, M.
A1  - Carlson, P.
A1  - Celestin, S.
A1  - Cermeno, M.
A1  - Chen, A.
A1  - Cheung, C. C.
A1  - Churazov, E.
A1  - Ciprini, S.
A1  - Coc, A.
A1  - Colafrancesco, S.
A1  - Coleiro, A.
A1  - Collmar, W.
A1  - Coppi, P.
A1  - Curado da Silva, R.
A1  - Cutini, S.
A1  - De Lotto, B.
A1  - de Martino, D.
A1  - De Rosa, A.
A1  - Del Santo, M.
A1  - Delgado, L.
A1  - Diehl, R.
A1  - Dietrich, S.
A1  - Dolgov, A. D.
A1  - Dominguez, A.
A1  - Prester, D. Dominis
A1  - Donnarumma, I.
A1  - Dorner, D.
A1  - Doro, M.
A1  - Dutra, M.
A1  - Elsaesser, D.
A1  - Fabrizio, M.
A1  - Fernandez-Barral, A.
A1  - Fioretti, V.
A1  - Foffano, L.
A1  - Formato, V.
A1  - Fornengo, N.
A1  - Foschini, L.
A1  - Franceschini, A.
A1  - Franckowiak, A.
A1  - Funk, S.
A1  - Fuschino, F.
A1  - Gaggero, D.
A1  - Galanti, G.
A1  - Gargano, F.
A1  - Gasparrini, D.
A1  - Gehrz, R.
A1  - Giammaria, P.
A1  - Giglietto, N.
A1  - Giommi, P.
A1  - Giordano, F.
A1  - Giroletti, M.
A1  - Ghirlanda, G.
A1  - Godinovic, N.
A1  - Gouiffes, C.
A1  - Grove, J. E.
A1  - Hamadache, C.
A1  - Hartmann, D. H.
A1  - Hayashida, M.
A1  - Hryczuk, A.
A1  - Jean, P.
A1  - Johnson, T.
A1  - Jose, J.
A1  - Kaufmann, S.
A1  - Khelifi, B.
A1  - Kiener, J.
A1  - Knodlseder, J.
A1  - Kolem, M.
A1  - Kopp, J.
A1  - Kozhuharov, V.
A1  - Labanti, C.
A1  - Lalkovski, S.
A1  - Laurent, P.
A1  - Limousin, O.
A1  - Linares, M.
A1  - Lindfors, E.
A1  - Lindner, M.
A1  - Liu, J.
A1  - Lombardi, S.
A1  - Loparco, F.
A1  - Lopez-Coto, R.
A1  - Lopez Moya, M.
A1  - Lott, B.
A1  - Lubrano, P.
A1  - Malyshev, D.
A1  - Mankuzhiyil, N.
A1  - Mannheim, K.
A1  - Marcha, M. J.
A1  - Marciano, A.
A1  - Marcote, B.
A1  - Mariotti, M.
A1  - Marisaldi, M.
A1  - McBreen, S.
A1  - Mereghetti, S.
A1  - Merle, A.
A1  - Mignani, R.
A1  - Minervini, G.
A1  - Moiseev, A.
A1  - Morselli, A.
A1  - Moura, F.
A1  - Nakazawa, K.
A1  - Nava, L.
A1  - Nieto, D.
A1  - Orienti, M.
A1  - Orio, M.
A1  - Orlando, E.
A1  - Orleanski, P.
A1  - Paiano, S.
A1  - Paoletti, R.
A1  - Papitto, A.
A1  - Pasquato, M.
A1  - Patricelli, B.
A1  - Perez-Garcia, M. A.
A1  - Persic, M.
A1  - Piano, G.
A1  - Pichel, A.
A1  - Pimenta, M.
A1  - Pittori, C.
A1  - Porter, T.
A1  - Poutanen, J.
A1  - Prandini, E.
A1  - Prantzos, N.
A1  - Produit, N.
A1  - Profumo, S.
A1  - Queiroz, F. S.
A1  - Raino, S.
A1  - Raklev, A.
A1  - Regis, M.
A1  - Reichardt, I.
A1  - Rephaeli, Y.
A1  - Rico, J.
A1  - Rodejohann, W.
A1  - Fernandez, G. Rodriguez
A1  - Roncadelli, M.
A1  - Roso, L.
A1  - Rovero, A.
A1  - Ruffini, R.
A1  - Sala, G.
A1  - Sanchez-Conde, M. A.
A1  - Santangelo, A.
A1  - Parkinson, P. Saz
A1  - Sbarrato, T.
A1  - Shearer, A.
A1  - Shellard, R.
A1  - Short, K.
A1  - Siegert, T.
A1  - Siqueira, C.
A1  - Spinelli, P.
A1  - Stamerra, A.
A1  - Starrfield, S.
A1  - Strong, A.
A1  - Strumke, I.
A1  - Tavecchio, F.
A1  - Taverna, R.
A1  - Terzic, T.
A1  - Thompson, D. J.
A1  - Tibolla, O.
A1  - Torres, D. F.
A1  - Turolla, R.
A1  - Ulyanov, A.
A1  - Ursi, A.
A1  - Vacchi, A.
A1  - Van den Abeele, J.
A1  - Vankova-Kirilovai, G.
A1  - Venter, C.
A1  - Verrecchia, F.
A1  - Vincent, P.
A1  - Wang, X.
A1  - Weniger, C.
A1  - Wu, X.
A1  - Zaharijas, G.
A1  - Zampieri, L.
A1  - Zane, S.
A1  - Zimmer, S.
A1  - Zoglauer, A.
T1  - Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics
JF  - Journal of High Energy Astrophysics
Y1  - 2018
U6  - https://doi.org/10.1016/j.jheap.2018.07.001
SN  - 2214-4048
SN  - 2214-4056
VL  - 19
SP  - 1
EP  - 106
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Tatischeff, V.
A1  - De Angelis, A.
A1  - Tavani, M.
A1  - Grenier, I.
A1  - Oberlack, U.
A1  - Hanlon, L.
A1  - Walter, R.
A1  - Argan, A.
A1  - von Ballmoos, P.
A1  - Bulgarelli, A.
A1  - Donnarumma, I.
A1  - Hernanz, Margarita
A1  - Kuvvetli, I.
A1  - Mallamaci, M.
A1  - Pearce, M.
A1  - Zdziarski, A.
A1  - Aboudan, A.
A1  - Ajello, M.
A1  - Ambrosi, G.
A1  - Bernard, D.
A1  - Bernardini, E.
A1  - Bonvicini, V.
A1  - Brogna, A.
A1  - Branchesi, M.
A1  - Budtz-Jorgensen, C.
A1  - Bykov, A.
A1  - Campana, R.
A1  - Cardillo, M.
A1  - Ciprini, S.
A1  - Coppi, P.
A1  - Cumani, P.
A1  - da Silva, R. M. Curado
A1  - De Martino, D.
A1  - Diehl, R.
A1  - Doro, M.
A1  - Fioretti, V.
A1  - Funk, S.
A1  - Ghisellini, G.
A1  - Giordano, F.
A1  - Grove, J. E.
A1  - Hamadache, C.
A1  - Hartmann, D. H.
A1  - Hayashida, M.
A1  - Isern, J.
A1  - Kanbach, G.
A1  - Kiener, J.
A1  - Knodlseder, J.
A1  - Labanti, C.
A1  - Laurent, P.
A1  - Leising, M.
A1  - Limousin, O.
A1  - Longo, F.
A1  - Mannheim, K.
A1  - Marisaldi, M.
A1  - Martinez, M.
A1  - Mazziotta, M. N.
A1  - McEnery, J. E.
A1  - Mereghetti, S.
A1  - Minervini, G.
A1  - Moiseev, A.
A1  - Morselli, A.
A1  - Nakazawa, K.
A1  - Orleanski, P.
A1  - Paredes, J. M.
A1  - Patricelli, B.
A1  - Peyre, J.
A1  - Piano, G.
A1  - Pohl, Martin
A1  - Rando, R.
A1  - Roncadelli, M.
A1  - Tavecchio, F.
A1  - Thompson, D. J.
A1  - Turolla, R.
A1  - Ulyanov, A.
A1  - Vacchi, A.
A1  - Wu, X.
A1  - Zoglauer, A.
ED  - DenHerder, JWA Nikzad
T1  - The e-ASTROGAM gamma-ray space observatory for the multimessenger astronomy of the 2030s
T2  - Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray
N2  - e-ASTROGAM is a concept for a breakthrough observatory space mission carrying a gamma-ray telescope dedicated to the study of the non-thermal Universe in the photon energy range from 0.15 MeV to 3 GeV. The lower energy limit can be pushed down to energies as low as 30 keV for gamma-ray burst detection with the calorimeter. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with remarkable polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous and current generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will be a major player of the multiwavelength, multimessenger time-domain astronomy of the 2030s, and provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LISA, LIGO, Virgo, KAGRA, the Einstein Telescope and the Cosmic Explorer, IceCube-Gen2 and KM3NeT, SKA, ALMA, JWST, E-ELT, LSST, Athena, and the Cherenkov Telescope Array.
KW  - Gamma-ray astronomy
KW  - time-domain astronomy
KW  - space mission
KW  - Compton and pair creation telescope
KW  - gamma-ray polarization
KW  - high-energy astrophysical phenomena
Y1  - 2018
SN  - 978-1-5106-1952-4
U6  - https://doi.org/10.1117/12.2315151
SN  - 0277-786X
SN  - 1996-756X
VL  - 10699
PB  - SPIE - The International Society for Optical Engineering
CY  - Bellingham
ER  - 
TY  - JOUR
A1  - De Angelis, A.
A1  - Tatischeff, V.
A1  - Tavani, M.
A1  - Oberlack, U.
A1  - Grenier, I.
A1  - Hanloni, L.
A1  - Walter, R.
A1  - Argan, A.
A1  - Von Ballmoos, P.
A1  - Bulgarelli, A.
A1  - Donnarumma, I.
A1  - Hernanz, M.
A1  - Kuvvetli, I.
A1  - Pearce, M.
A1  - Zdziarski, A.
A1  - Aboudan, A.
A1  - Ajello, M.
A1  - Ambrosi, G.
A1  - Bernard, D.
A1  - Bernardini, E.
A1  - Bonvicini, V.
A1  - Brogna, A.
A1  - Branchesi, M.
A1  - Budtz-Jorgensen, C.
A1  - Bykov, A. M.
A1  - Campana, R.
A1  - Cardillo, M.
A1  - Coppi, P.
A1  - De Martino, D.
A1  - Diehl, R.
A1  - Doro, M.
A1  - Fioretti, V.
A1  - Funk, S.
A1  - Ghisellini, G.
A1  - Grove, E.
A1  - Hamadache, C.
A1  - Hartmann, D. H.
A1  - Hayashida, M.
A1  - Isern, J.
A1  - Kanbach, G.
A1  - Kiener, J.
A1  - Knodlseder, J.
A1  - Labanti, C.
A1  - Laurent, P.
A1  - Limousin, O.
A1  - Longo, F.
A1  - Mannheim, K.
A1  - Marisaldi, M.
A1  - Martinez, M.
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J.
A1  - Mereghetti, S.
A1  - Minervini, G.
A1  - Moiseev, A.
A1  - Morselli, A.
A1  - Nakazawa, K.
A1  - Orleanski, P.
A1  - Paredes, J. M.
A1  - Patricelli, B.
A1  - Pevre, J.
A1  - Piano, G.
A1  - Pohl, Martin
A1  - Ramarijaona, H.
A1  - Rando, R.
A1  - Reichardt, I.
A1  - Roncadelli, M.
A1  - Silva, R.
A1  - Tavecchio, F.
A1  - Thompson, D. J.
A1  - Turolla, R.
A1  - Ulyanov, A.
A1  - Vacchi, A.
A1  - Wu, X.
A1  - Zoglauer, A.
T1  - The e-ASTROGAM mission Exploring the extreme Universe with gamma rays in the MeV - GeV range
JF  - Experimental astronomy : an international journal on astronomical instrumentation and data analysis
N2  - e-ASTROGAM (‘enhanced ASTROGAM’) is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV – the lower energy limit can be pushed to energies as low as 150 keV, albeit with rapidly degrading angular resolution, for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and the promise of eLISA.
KW  - High-Energy Gamma-Ray Astronomy
KW  - High-Energy Astrophysics
KW  - Nuclear Astrophysics
KW  - Compton and Pair Creation Telescope
KW  - Gamma-Ray Bursts
KW  - Active Galactic Nuclei
KW  - Jets
KW  - Outflows
KW  - Multiwavelength Observations of the Universe
KW  - Counterparts of gravitational waves
KW  - Fermi
KW  - Dark Matter
KW  - Nucleosynthesis
KW  - Early Universe
KW  - Supernovae
KW  - Cosmic Rays
KW  - Cosmic Antimatter
Y1  - 2017
U6  - https://doi.org/10.1007/s10686-017-9533-6
SN  - 0922-6435
SN  - 1572-9508
VL  - 44
SP  - 25
EP  - 82
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - GEN
A1  - Deeken, Friederike
A1  - Reichert, Markus
A1  - Zech, Hilmar
A1  - Wenzel, Julia
A1  - Wedemeyer, Friederike
A1  - Aguilera, Alvaro
A1  - Aslan, Acelya
A1  - Bach, Patrick
A1  - Bahr, Nadja Samia
A1  - Ebrahimi, Claudia
A1  - Fischbach, Pascale Christine
A1  - Ganz, Marvin
A1  - Garbusow, Maria
A1  - Großkopf, Charlotte M.
A1  - Heigert, Marie
A1  - Hentschel, Angela
A1  - Karl, Damian
A1  - Pelz, Patricia
A1  - Pinger, Mathieu
A1  - Riemerschmid, Carlotta
A1  - Rosenthal, Annika
A1  - Steffen, Johannes
A1  - Strehle, Jens
A1  - Weiss, Franziska
A1  - Wieder, Gesine
A1  - Wieland, Alfred
A1  - Zaiser, Judith
A1  - Zimmermann, Sina
A1  - Walter, Henrik
A1  - Lenz, Bernd
A1  - Deserno, Lorenz
A1  - Smolka, Michael N.
A1  - Liu, Shuyan
A1  - Ebner-Priemer, Ulrich Walter
A1  - Heinz, Andreas
A1  - Rapp, Michael Armin
T1  - Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany
T2  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - Importance  Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence.

Objective  To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanisms.

Design, Setting, and Participants  This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites from February 20, 2020, to February 28, 2021. Data were provided before and within the second lockdown of the COVID-19 pandemic in Germany: before lockdown (October 2 to November 1, 2020); light lockdown (November 2 to December 15, 2020); and hard lockdown (December 16, 2020, to February 28, 2021).

Main Outcomes and Measures  Daily ratings of AC (main outcome) captured during 3 lockdown phases (main variable) and temporal (weekends and holidays) and psychological (social isolation and drinking intention) correlates.

Results  Of the 1743 screened participants, 189 (119 [63.0%] male; median [IQR] age, 37 [27.5-52.0] years) with at least 2 alcohol use disorder (AUD) criteria according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) yet without the need for medically supervised alcohol withdrawal were included. These individuals provided 14 694 smartphone ratings from October 2020 through February 2021. Multilevel modeling revealed significantly higher AC (grams of alcohol per day) on weekend days vs weekdays (β = 11.39; 95% CI, 10.00-12.77; P < .001). Alcohol consumption was above the overall average on Christmas (β = 26.82; 95% CI, 21.87-31.77; P < .001) and New Year’s Eve (β = 66.88; 95% CI, 59.22-74.54; P < .001). During the hard lockdown, perceived social isolation was significantly higher (β = 0.12; 95% CI, 0.06-0.15; P < .001), but AC was significantly lower (β = −5.45; 95% CI, −8.00 to −2.90; P = .001). Independent of lockdown, intention to drink less alcohol was associated with lower AC (β = −11.10; 95% CI, −13.63 to −8.58; P < .001). Notably, differences in AC between weekend and weekdays decreased both during the hard lockdown (β = −6.14; 95% CI, −9.96 to −2.31; P = .002) and in participants with severe AUD (β = −6.26; 95% CI, −10.18 to −2.34; P = .002).

Conclusions and Relevance  This 5-month cohort study found no immediate negative associations of lockdown measures with overall AC. Rather, weekend-weekday and holiday AC patterns exceeded lockdown effects. Differences in AC between weekend days and weekdays evinced that weekend drinking cycles decreased as a function of AUD severity and lockdown measures, indicating a potential mechanism of losing and regaining control. This finding suggests that temporal patterns and drinking intention constitute promising targets for prevention and intervention, even in high-risk individuals.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 805 
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-571460
SN  - 1866-8364
IS  - 805
ER  - 
TY  - JOUR
A1  - Deeken, Friederike
A1  - Reichert, Markus
A1  - Zech, Hilmar
A1  - Wenzel, Julia
A1  - Wedemeyer, Friederike
A1  - Aguilera, Alvaro
A1  - Aslan, Acelya
A1  - Bach, Patrick
A1  - Bahr, Nadja Samia
A1  - Ebrahimi, Claudia
A1  - Fischbach, Pascale Christine
A1  - Ganz, Marvin
A1  - Garbusow, Maria
A1  - Großkopf, Charlotte M.
A1  - Heigert, Marie
A1  - Hentschel, Angela
A1  - Karl, Damian
A1  - Pelz, Patricia
A1  - Pinger, Mathieu
A1  - Riemerschmid, Carlotta
A1  - Rosenthal, Annika
A1  - Steffen, Johannes
A1  - Strehle, Jens
A1  - Weiss,, Franziska
A1  - Wieder, Gesine
A1  - Wieland, Alfred
A1  - Zaiser, Judith
A1  - Zimmermann, Sina
A1  - Walter, Henrik
A1  - Lenz, Bernd
A1  - Deserno, Lorenz
A1  - Smolka, Michael N.
A1  - Liu, Shuyan
A1  - Ebner-Priemer, Ulrich Walter
A1  - Heinz, Andreas
A1  - Rapp, Michael Armin
T1  - Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany
JF  - JAMA Network Open
N2  - Importance  Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence.

Objective  To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanisms.

Design, Setting, and Participants  This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites from February 20, 2020, to February 28, 2021. Data were provided before and within the second lockdown of the COVID-19 pandemic in Germany: before lockdown (October 2 to November 1, 2020); light lockdown (November 2 to December 15, 2020); and hard lockdown (December 16, 2020, to February 28, 2021).

Main Outcomes and Measures  Daily ratings of AC (main outcome) captured during 3 lockdown phases (main variable) and temporal (weekends and holidays) and psychological (social isolation and drinking intention) correlates.

Results  Of the 1743 screened participants, 189 (119 [63.0%] male; median [IQR] age, 37 [27.5-52.0] years) with at least 2 alcohol use disorder (AUD) criteria according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) yet without the need for medically supervised alcohol withdrawal were included. These individuals provided 14 694 smartphone ratings from October 2020 through February 2021. Multilevel modeling revealed significantly higher AC (grams of alcohol per day) on weekend days vs weekdays (β = 11.39; 95% CI, 10.00-12.77; P < .001). Alcohol consumption was above the overall average on Christmas (β = 26.82; 95% CI, 21.87-31.77; P < .001) and New Year’s Eve (β = 66.88; 95% CI, 59.22-74.54; P < .001). During the hard lockdown, perceived social isolation was significantly higher (β = 0.12; 95% CI, 0.06-0.15; P < .001), but AC was significantly lower (β = −5.45; 95% CI, −8.00 to −2.90; P = .001). Independent of lockdown, intention to drink less alcohol was associated with lower AC (β = −11.10; 95% CI, −13.63 to −8.58; P < .001). Notably, differences in AC between weekend and weekdays decreased both during the hard lockdown (β = −6.14; 95% CI, −9.96 to −2.31; P = .002) and in participants with severe AUD (β = −6.26; 95% CI, −10.18 to −2.34; P = .002).

Conclusions and Relevance  This 5-month cohort study found no immediate negative associations of lockdown measures with overall AC. Rather, weekend-weekday and holiday AC patterns exceeded lockdown effects. Differences in AC between weekend days and weekdays evinced that weekend drinking cycles decreased as a function of AUD severity and lockdown measures, indicating a potential mechanism of losing and regaining control. This finding suggests that temporal patterns and drinking intention constitute promising targets for prevention and intervention, even in high-risk individuals.
Y1  - 2022
U6  - https://doi.org/10.1001/jamanetworkopen.2022.24641
SN  - 2574-3805
VL  - 5
SP  - 1
EP  - 11
PB  - JAMA Network / American Medical Association
CY  - Chicago, Illinois, USA
ET  - 8
ER  - 
TY  - JOUR
A1  - Renteria, Miguel E.
A1  - Schmaal, L.
A1  - Hibar, D. P.
A1  - Couvy-Duchesne, B.
A1  - Strike, L. T.
A1  - Mills, N. T.
A1  - de Zubicaray, Greig. I.
A1  - McMahon, Katie. L.
A1  - Medland, Sarah E.
A1  - Gillespie, N. A.
A1  - Hatton, S. N.
A1  - Lagopoulos, J.
A1  - Veltman, D. J.
A1  - van der Wee, N.
A1  - van Erp, T. G. M.
A1  - Wittfeld, K.
A1  - Grabe, H. J.
A1  - Block, Andrea
A1  - Hegenscheid, K.
A1  - Voelzke, H.
A1  - Veer, I. M.
A1  - Walter, H.
A1  - Schnell, K.
A1  - Schramm, E.
A1  - Normann, C.
A1  - Schoepf, Dieter
A1  - Konrad, C.
A1  - Zurowski, B.
A1  - Godlewska, B. R.
A1  - Cowen, P. J.
A1  - Penninx, B. W. J. H.
A1  - Jahanshad, N.
A1  - Thompson, Paul M.
A1  - Wright, M. J.
A1  - Martin, N. G.
A1  - Christensen, H.
A1  - Hickie, I. B.
T1  - Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group
JF  - Translational Psychiatry
Y1  - 2017
U6  - https://doi.org/10.1038/tp.2017.84
SN  - 2158-3188
VL  - 7
SP  - 2301
EP  - 2320
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Frodl, Thomas
A1  - Janowitz, Deborah
A1  - Schmaal, Lianne
A1  - Tozzi, Leonardo
A1  - Dobrowolny, Henrik
A1  - Stein, Dan J.
A1  - Veltman, Dick J.
A1  - Wittfeld, Katharina
A1  - van Erp, Theo G. M.
A1  - Jahanshad, Neda
A1  - Block, Andrea
A1  - Hegenscheid, Katrin
A1  - Voelzke, Henry
A1  - Lagopoulos, Jim
A1  - Hatton, Sean N.
A1  - Hickie, Ian B.
A1  - Frey, Eva Maria
A1  - Carballedo, Angela
A1  - Brooks, Samantha J.
A1  - Vuletic, Daniella
A1  - Uhlmann, Anne
A1  - Veer, Ilya M.
A1  - Walter, Henrik
A1  - Schnell, Knut
A1  - Grotegerd, Dominik
A1  - Arolt, Volker
A1  - Kugel, Harald
A1  - Schramm, Elisabeth
A1  - Konrad, Carsten
A1  - Zurowski, Bartosz
A1  - Baune, Bernhard T.
A1  - van der Wee, Nic J. A.
A1  - van Tol, Marie-Jose
A1  - Penninx, Brenda W. J. H.
A1  - Thompson, Paul M.
A1  - Hibar, Derrek P.
A1  - Dannlowski, Udo
A1  - Grabe, Hans J.
T1  - Childhood adversity impacts on brain subcortical structures relevant to depression
JF  - Journal of psychiatric research
N2  - Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression. (C) 2016 Published by Elsevier Ltd.
KW  - Depression
KW  - Childhood adversity
KW  - MRI
KW  - Caudate
KW  - Hippocampus
KW  - ENIGMA
Y1  - 2016
U6  - https://doi.org/10.1016/j.jpsychires.2016.11.010
SN  - 0022-3956
SN  - 1879-1379
VL  - 86
SP  - 58
EP  - 65
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Heslop, J. K.
A1  - Winkel, Matthias
A1  - Anthony, K. M. Walter
A1  - Spencer, R. G. M.
A1  - Podgorski, D. C.
A1  - Zito, P.
A1  - Kholodov, A.
A1  - Zhang, M.
A1  - Liebner, Susanne
T1  - Increasing organic carbon biolability with depth in yedoma permafrost
BT  - ramifications for future climate change
JF  - Journal of geophysical research : Biogeosciences
N2  - Permafrost thaw subjects previously frozen organic carbon (OC) to microbial decomposition, generating the greenhouse gases (GHG) carbon dioxide (CO2) and methane (CH4) and fueling a positive climate feedback. Over one quarter of permafrost OC is stored in deep, ice-rich Pleistocene-aged yedoma permafrost deposits. We used a combination of anaerobic incubations, microbial sequencing, and ultrahigh-resolution mass spectrometry to show yedoma OC biolability increases with depth along a 12-m yedoma profile. In incubations at 3 degrees C and 13 degrees C, GHG production per unit OC at 12-versus 1.3-m depth was 4.6 and 20.5 times greater, respectively. Bacterial diversity decreased with depth and we detected methanogens at all our sampled depths, suggesting that in situ microbial communities are equipped to metabolize thawed OC into CH4. We concurrently observed an increase in the relative abundance of reduced, saturated OC compounds, which corresponded to high proportions of C mineralization and positively correlated with anaerobic GHG production potentials and higher proportions of OC being mineralized as CH4. Taking into account the higher global warming potential (GWP) of CH4 compared to CO2, thawed yedoma sediments in our study had 2 times higher GWP at 12-versus 9.0-m depth at 3 degrees C and 15 times higher GWP at 13 degrees C. Considering that yedoma is vulnerable to processes that thaw deep OC, our findings imply that it is important to account for this increasing GHG production and GWP with depth to better understand the disproportionate impact of yedoma on the magnitude of the permafrost carbon feedback.
KW  - permafrost
KW  - carbon
KW  - yedoma
KW  - Alaska
KW  - FT-ICR MS
KW  - microbes
Y1  - 2019
U6  - https://doi.org/10.1029/2018JG004712
SN  - 2169-8953
SN  - 2169-8961
VL  - 124
IS  - 7
SP  - 2021
EP  - 2038
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Himmel, Mirko
A1  - VanderVen, Peter F. M.
A1  - Stöcklein, Walter F. M.
A1  - Fürst, Dieter Oswald
T1  - The limits of promiscuity : isoform-specific dimerization of filamins
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Krüger-Genge, A.
A1  - Braune, S.
A1  - Walter, M.
A1  - Krengel, M.
A1  - Kratz, K.
A1  - Küpper, J. H.
A1  - Lendlein, Andreas
A1  - Jung, Friedrich
T1  - Influence of different surface treatments of poly(n-butyl acrylate) networks on fibroblasts adhesion, morphology and viability
JF  - Clinical hemorheology and microcirculation : blood flow and vessels
N2  - BACKGROUND: Physical and chemical characteristics of implant materials determine the fate of long-term cardiovascular devices. However, there is still a lack of fundamental understanding of the molecular mechanisms occurring in the material-tissue interphase. In a previous study, soft covalently crosslinked poly(n-butyl acrylate) networks (cPnBA) were introduced as sterilizable, non-toxic and immuno-compatible biomaterials with mechanical properties adjustable to blood vessels. Here we study the influence of different surface treatments in particular oxygen plasma modification and fibrinogen deposition as well as a combinatorial approach on the adhesion and viability of fibroblasts. RESULTS: Compared to non-treated cPnBAs the advancing water-contact angles were found to be reduced after all surface modifications (p<0.05, each), while lowest values were observed after the combined surface treatment (OPT+FIB). The latter differed significantly from the single OPT and FIB. The number of adherent fibroblasts and their adherence behavior differed on both pristine cPnBA networks. The fibroblast density on cPnBA04 was 743 +/- 434 cells. mm(-2), was about 6.5 times higher than on cPnBA73 with 115 +/- 73 cells. mm(-2). On cPnBA04 about 20% of the cells were visible as very small, round and buckled cells while all other cells were in a migrating status. On cPnBA73, nearly 50% of fibroblasts were visible as very small, round and buckled cells. The surface functionalization either using oxygen plasma treatment or fibrinogen coating led to a significant increase of adherent fibroblasts, particularly the combination of both techniques, for both cPnBA networks. It is noteworthy to mention that the fibrinogen coating overruled the characteristics of the pristine surfaces; here, the fibroblast densities after seeding were identical for both cPnBAnetworks. Thus, the binding rather depended on the fibrinogen coating than on the substrate characteristics anymore. While the integrity of the fibroblasts membrane was comparable for both polymers, the MTS tests showed a decreased metabolic activity of the fibroblasts on cPnBA. CONCLUSION: The applied surface treatments of cPnBA successfully improved the adhesion of viable fibroblasts. Under resting conditions as well as after shearing the highest fibroblast densities were found on surfaces with combined post-treatment.
KW  - Biomaterial
KW  - poly(n-butyl acrylate)
KW  - fibroblast
KW  - oxygen plasma
KW  - fibrinogen
KW  - cell adhesion
KW  - focal adhesion
KW  - actin cytoskeleton
KW  - viability
Y1  - 2018
U6  - https://doi.org/10.3233/CH-189130
SN  - 1386-0291
SN  - 1875-8622
VL  - 69
IS  - 1-2
SP  - 305
EP  - 316
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Braune, Steffen
A1  - Gross, M.
A1  - Walter, M.
A1  - Zhou, Shengqiang
A1  - Dietze, Siegfried
A1  - Rutschow, S.
A1  - Lendlein, Andreas
A1  - Tschoepe, C.
A1  - Jung, Friedrich
T1  - Adhesion and activation of platelets from subjects with coronary artery disease and apparently healthy individuals on biomaterials
JF  - Journal of biomedical materials research : an official journal of the Society for Biomaterials, the Japanese Society for Biomaterials; the Australian Society for Biomaterials
N2  - On the basis of the clinical studies in patients with coronary artery disease (CAD) presenting an increased percentage of activated platelets, we hypothesized that hemocompatibility testing utilizing platelets from healthy individuals may result in an underestimation of the materials' thrombogenicity. Therefore, we investigated the interaction of polymer-based biomaterials with platelets from CAD patients in comparison to platelets from apparently healthy individuals. In vitro static thrombogenicity tests revealed that adherent platelet densities and total platelet covered areas were significantly increased for the low (polydimethylsiloxane, PDMS) and medium (Collagen) thrombogenic surfaces in the CAD group compared to the healthy subjects group. The area per single platelet—indicating the spreading and activation of the platelets—was markedly increased on PDMS treated with PRP from CAD subjects. This could not be observed for collagen or polytetrafluoroethylene (PTFE). For the latter material, platelet adhesion and surface coverage did not differ between the two groups. Irrespective of the substrate, the variability of these parameters was increased for CAD patients compared to healthy subjects. This indicates a higher reactivity of platelets from CAD patients compared to the healthy individuals. Our results revealed, for the first time, that utilizing platelets from apparently healthy donors bears the risk of underestimating the thrombogenicity of polymer-based biomaterials.
KW  - platelets
KW  - biomaterials
KW  - hemocompatibility
KW  - cardiovascular disease
KW  - cardiovascular implant
Y1  - 2016
U6  - https://doi.org/10.1002/jbm.b.33366
SN  - 1552-4973
SN  - 1552-4981
VL  - 104
SP  - 210
EP  - 217
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Lenz, Josefine
A1  - Grosse, Guido
A1  - Jones, Benjamin M.
A1  - Anthony, Katey M. Walter
A1  - Bobrov, Anatoly
A1  - Wulf, Sabine
A1  - Wetterich, Sebastian
T1  - Mid-Wisconsin to Holocene Permafrost and Landscape Dynamics based on a Drained Lake Basin Core from the Northern Seward Peninsula, Northwest Alaska
JF  - Permafrost and Periglacial Processes
N2  - Permafrost-related processes drive regional landscape dynamics in the Arctic terrestrial system. A better understanding of past periods indicative of permafrost degradation and aggradation is important for predicting the future response of Arctic landscapes to climate change. Here, we used a multi-proxy approach to analyse a4m long sediment core from a drained thermokarst lake basin on the northern Seward Peninsula in western Arctic Alaska (USA). Sedimentological, biogeochemical, geochronological, micropalaeontological (ostracoda, testate amoebae) and tephra analyses were used to determine the long-term environmental Early-Wisconsin to Holocene history preserved in our core for central Beringia. Yedoma accumulation dominated throughout the Early to Late-Wisconsin but was interrupted by wetland formation from 44.5 to 41.5ka BP. The latter was terminated by the deposition of 1m of volcanic tephra, most likely originating from the South Killeak Maar eruption at about 42ka BP. Yedoma deposition continued until 22.5ka BP and was followed by a depositional hiatus in the sediment core between 22.5 and 0.23ka BP. We interpret this hiatus as due to intense thermokarst activity in the areas surrounding the site, which served as a sediment source during the Late-Wisconsin to Holocene climate transition. The lake forming the modern basin on the upland initiated around 0.23ka BP and drained catastrophically in spring 2005. The present study emphasises that Arctic lake systems and periglacial landscapes are highly dynamic and that permafrost formation as well as degradation in central Beringia was controlled by regional to global climate patterns as well as by local disturbances. Copyright (c) 2015 John Wiley & Sons, Ltd.
KW  - Beringia
KW  - palaeoenvironmental reconstruction
KW  - thermokarst lake dynamics
KW  - cryostratigraphy
KW  - tephra
KW  - bioindicators
KW  - yedoma
Y1  - 2016
U6  - https://doi.org/10.1002/ppp.1848
SN  - 1045-6740
SN  - 1099-1530
VL  - 27
SP  - 56
EP  - 75
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Rohde, M.
A1  - Scharte, Gudrun
A1  - Behrsing, Olaf
A1  - Warsinke, Axel
A1  - Micheel, Burkhard
A1  - Scheller, Frieder W.
T1  - Sensitive detection of triazine and phenylurea pesticides in pure organic solvent by enzyme linked immunsorbent assay (ELISA): stabilities, solubilities and sensitives
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Foerster, Verena
A1  - Asrat, Asfawossen
A1  - Ramsey, Christopher Bronk
A1  - Brown, Erik T.
A1  - Chapot, Melissa S.
A1  - Deino, Alan
A1  - Düsing, Walter
A1  - Grove, Matthew
A1  - Hahn, Annette
A1  - Junginger, Annett
A1  - Kaboth-Bahr, Stefanie
A1  - Lane, Christine S.
A1  - Opitz, Stephan
A1  - Noren, Anders
A1  - Roberts, Helen M.
A1  - Stockhecke, Mona
A1  - Tiedemann, Ralph
A1  - Vidal, Celine M.
A1  - Vogelsang, Ralf
A1  - Cohen, Andrew S.
A1  - Lamb, Henry F.
A1  - Schaebitz, Frank
A1  - Trauth, Martin H.
T1  - Pleistocene climate variability in eastern Africa influenced hominin evolution
JF  - Nature geoscience
N2  - Despite more than half a century of hominin fossil discoveries in eastern Africa, the regional environmental context of hominin evolution and dispersal is not well established due to the lack of continuous palaeoenvironmental records from one of the proven habitats of early human populations, particularly for the Pleistocene epoch. Here we present a 620,000-year environmental record from Chew Bahir, southern Ethiopia, which is proximal to key fossil sites. Our record documents the potential influence of different episodes of climatic variability on hominin biological and cultural transformation. The appearance of high anatomical diversity in hominin groups coincides with long-lasting and relatively stable humid conditions from similar to 620,000 to 275,000 years bp (episodes 1-6), interrupted by several abrupt and extreme hydroclimate perturbations. A pattern of pronounced climatic cyclicity transformed habitats during episodes 7-9 (similar to 275,000-60,000 years bp), a crucial phase encompassing the gradual transition from Acheulean to Middle Stone Age technologies, the emergence of Homo sapiens in eastern Africa and key human social and cultural innovations. Those accumulative innovations plus the alignment of humid pulses between northeastern Africa and the eastern Mediterranean during high-frequency climate oscillations of episodes 10-12 (similar to 60,000-10,000 years bp) could have facilitated the global dispersal of H. sapiens.
KW  - Evolutionary ecology
KW  - Limnology
KW  - Palaeoclimate
Y1  - 2022
U6  - https://doi.org/10.1038/s41561-022-01032-y
SN  - 1752-0894
SN  - 1752-0908
VL  - 15
IS  - 10
SP  - 805
EP  - 811
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Bozzo, Enrico
A1  - Bhalerao, V.
A1  - Pradhan, Prajal
A1  - Tomsick, J.
A1  - Romano, Patrizia
A1  - Ferrigno, Carlo
A1  - Chaty, S.
A1  - Oskinova, Lida
A1  - Manousakis, A.
A1  - Walter, R.
A1  - Falanga, M.
A1  - Campana, S.
A1  - Stella, L.
A1  - Ramolla, M.
A1  - Chini, R.
T1  - Multi-wavelength observations of IGR J17544-2619 from quiescence to outburst
JF  - Journal of geophysical research : Earth surface
N2  - In this paper we report on a long multi-wavelength observational campaign of the supergiant fast X-ray transient prototype IGR J17544-2619. A 150 ks-long observation was carried out simultaneously with XMM-Newton and NuSTAR, catching the source in an initial faint X-ray state and then undergoing a bright X-ray outburst lasting approximately 7 ks. We studied the spectral variability during outburst and quiescence by using a thermal and bulk Comptonization model that is typically adopted to describe the X-ray spectral energy distribution of young pulsars in high mass X-ray binaries. Although the statistics of the collected X-ray data were relatively high, we could neither confirm the presence of a cyclotron line in the broad-band spectrum of the source (0.5-40 keV), nor detect any of the previously reported tentative detections of the source spin period. The monitoring carried out with Swift/XRT during the same orbit of the system observed by XMM-Newton and NuSTAR revealed that the source remained in a low emission state for most of the time, in agreement with the known property of all supergiant fast X-ray transients being significantly sub-luminous compared to other supergiant X-ray binaries. Optical and infrared observations were carried out for a total of a few thousand seconds during the quiescence state of the source detected by XMM-Newton and NuSTAR. The measured optical and infrared magnitudes were slightly lower than previous values reported in the literature, but compatible with the known micro-variability of supergiant stars. UV observations obtained with the UVOT telescope on-board Swift did not reveal significant changes in the magnitude of the source in this energy domain compared to previously reported values.
KW  - X-rays: binaries
Y1  - 2016
U6  - https://doi.org/10.1051/0004-6361/201629311
SN  - 1432-0746
VL  - 596
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Kyriakos, Konstantinos
A1  - Philipp, Martine
A1  - Adelsberger, Joseph
A1  - Jaksch, Sebastian
A1  - Berezkin, Anatoly V.
A1  - Lugo, Dersy M.
A1  - Richtering, Walter
A1  - Grillo, Isabelle
A1  - Miasnikova, Anna
A1  - Laschewsky, André
A1  - Müller-Buschbaum, Peter
A1  - Papadakis, Christine M.
T1  - Cononsolvency of water/methanol mixtures for PNIPAM and PS-b-PNIPAM: pathway of aggregate formation investigated using time-resolved SANS
JF  - Macromolecules : a publication of the American Chemical Society
N2  - We investigate the cononsolvency effect of poly(N-isopropylacrylamide) (PNIPAM) in mixtures of water and methanol. Two systems are studied: micellar solutions of polystyrene-b-poly(N-isopropylacrylamide) (PS-b-PNIPAM) diblock copolymers and, as a reference, solutions of PNIPAM homopolymers, both at a concentration of 20 mg/mL in DO. Using a stopped-flow instrument, fully deuterated methanol was rapidly added to these solutions at volume fractions between 10 and 20%. Time-resolved turbidimetry revealed aggregate formation within 10-100 s. The structural changes on mesoscopic length scales were followed by time-resolved small-angle neutron scattering (TR-SANS) with a time resolution of 0.1 s. In both systems, the pathway of the aggregation depends on the content of deuterated methanol; however, it is fundamentally different for homopolymer and diblock copolymer solutions: In the former, very large aggregates (>150 nm) are formed within the dead time of the setup, gradient appears at their surface in the late stages. In contrast, the growth of the aggregates in the latter system features different regimes, and the final aggregate size is 50 nm, thus much smaller than for the homopolymer. For the diblock copolymer, the time dependence of the aggregate radius can be described by two models: In the initial stage, the diffusion-limited coalescence model describes the data well; however, the resulting coalescence time is unreasonably high. In the late stage, a logarithmic coalescence model based on an energy barrier which is proportional to the aggregate radius is successfully applied. and a concentration
Y1  - 2014
U6  - https://doi.org/10.1021/ma501434e
SN  - 0024-9297
SN  - 1520-5835
VL  - 47
IS  - 19
SP  - 6867
EP  - 6879
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Garbusow, Maria
A1  - Schad, Daniel
A1  - Sebold, Miriam Hannah
A1  - Friedel, Eva
A1  - Bernhardt, Nadine
A1  - Koch, Stefan P.
A1  - Steinacher, Bruno
A1  - Kathmann, Norbert
A1  - Geurts, Dirk E. M.
A1  - Sommer, Christian
A1  - Mueller, Dirk K.
A1  - Nebe, Stephan
A1  - Paul, Soeren
A1  - Wittchen, Hans-Ulrich
A1  - Zimmermann, Ulrich S.
A1  - Walter, Henrik
A1  - Smolka, Michael N.
A1  - Sterzer, Philipp
A1  - Rapp, Michael Armin
A1  - Huys, Quentin J. M.
A1  - Schlagenhauf, Florian
A1  - Heinz, Andreas
T1  - Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence
JF  - Addiction biology
N2  - In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n=31 detoxified patients diagnosed with alcohol dependence and n=24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence.
KW  - human Pavlovian-to-instrumental transfer
KW  - nucleus accumbens
KW  - relapse in alcohol use disorder
Y1  - 2016
U6  - https://doi.org/10.1111/adb.12243
SN  - 1355-6215
SN  - 1369-1600
VL  - 21
SP  - 719
EP  - 731
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Garbusow, Maria
A1  - Nebe, Stephan
A1  - Sommer, Christian
A1  - Kuitunen-Paul, Sören
A1  - Sebold, Miriam Hannah
A1  - Schad, Daniel
A1  - Friedel, Eva
A1  - Veer, Ilya M.
A1  - Wittchen, Hans-Ulrich
A1  - Rapp, Michael Armin
A1  - Ripke, Stephan
A1  - Walter, Henrik
A1  - Huys, Quentin J. M.
A1  - Schlagenhauf, Florian
A1  - Smolka, Michael N.
A1  - Heinz, Andreas
T1  - Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers
BT  - Behavioral, Neural and Polygenic Correlates
T2  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 841 
KW  - Pavlovian-to-instrumental transfer
KW  - amygdala
KW  - alcohol
KW  - polygenic risk
KW  - high risk drinkers
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473280
SN  - 1866-8364
IS  - 841
ER  - 
TY  - JOUR
A1  - Garbusow, Maria
A1  - Nebe, Stephan
A1  - Sommer, Christian
A1  - Kuitunen-Paul, Sören
A1  - Sebold, Miriam Hannah
A1  - Schad, Daniel
A1  - Friedel, Eva
A1  - Veer, Ilya M.
A1  - Wittchen, Hans-Ulrich
A1  - Rapp, Michael Armin
A1  - Ripke, Stephan
A1  - Walter, Henrik
A1  - Huys, Quentin J. M.
A1  - Schlagenhauf, Florian
A1  - Smolka, Michael N.
A1  - Heinz, Andreas
T1  - Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers
BT  - Behavioral, Neural and Polygenic Correlates
JF  - Journal of Clinical Medicine
N2  - In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.
KW  - Pavlovian-to-instrumental transfer
KW  - amygdala
KW  - alcohol
KW  - polygenic risk
KW  - high risk drinkers
Y1  - 2019
U6  - https://doi.org/10.3390/jcm8081188
SN  - 2077-0383
VL  - 8
IS  - 8
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Krah, Markus
A1  - Thulin, Mirjam
A1  - Faierstein, Morris M.
A1  - Drori, Danielle
A1  - Coors, Maria
A1  - Schramm, Netta
A1  - Driver, Cory
A1  - Holzman, Gitit
A1  - Zuckermann, Ghil‘ad
A1  - Fishbane, Eitan P.
A1  - Gruenbaum, Caroline
A1  - Schirrmeister, Sebastian
A1  - Ferrari, Francesco
A1  - Stemberger, Günter
A1  - Schmölz-Häberlein, Michaela
A1  - Müller, Judith
A1  - Schulz, Michael Karl
A1  - Meyer, Thomas
A1  - Artwińska, Anna
A1  - Walter, Simon
ED  - Krah, Markus
ED  - Thulin, Mirjam
ED  - Pick, Bianca
T1  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Transformative Translations in Jewish History and Culture
BT  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e. V.
N2  - PaRDeS, die Zeitschrift der Vereinigung für Jüdische Studien e. V., erforscht die fruchtbare kulturelle Vielfalt des Judentums sowie ihre Berührungspunkte zur nichtjüdischen Umwelt in unterschiedlichen Bereichen. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und ­Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung.
N2  - PaRDeS, the journal of the German Association for Jewish Studies, aims at exploring the fruitful and multifarious cultures of Judaism as well as their relations to their environment within diverse areas of research. In addition, the journal promotes Jewish Studies within academic discourse and reflects on its historic and social responsibilities.
T3  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 25 
KW  - Jüdische Studien
KW  - Übersetzungen
KW  - Bibel
KW  - Hebräisch
KW  - Jiddisch
KW  - Jewish Studies
KW  - Translations
KW  - Bible
KW  - Hebrew
KW  - Yiddish
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-432621
SN  - 978-3-86956-468-5
SN  - 1614-6492
SN  - 1862-7684
IS  - 25
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Nitsche, Andreas
A1  - Kurth, Andreas
A1  - Dunkhorst, Anna
A1  - Pänke, Oliver
A1  - Sielaff, Hendrik
A1  - Junge, Wolfgang
A1  - Muth, Doreen
A1  - Scheller, Frieder W.
A1  - Stöcklein, Walter F. M.
A1  - Pauli, Georg
A1  - Kage, Andreas
T1  - One-step selection of vaccinia virus binding DNA-aptamers by MonoLEX
Y1  - 2007
UR  - http://www.biomedcentral.com/1472-6750/7
U6  - https://doi.org/10.1186/1472-6750-7-48
ER  - 
TY  - JOUR
A1  - Neumann, Meina
A1  - Schulte, Marc
A1  - Jünemann, Nora
A1  - Stöcklein, Walter F. M.
A1  - Leimkühler, Silke
T1  - Rhodobacter capsulatus XdhC is involved in molybdenum cofactor binding and insertion into xanthine dehydrogenase
N2  - Rhodobacter capsulatus xanthine dehydrogenase (XDH) is a cytoplasmic enzyme with an (alpha beta) 2 heterodimeric structure that is highly identical to homodimeric eukaryotic xanthine oxidoreductases. The crystal structure revealed that the molybdenum cofactor (Moco) is deeply buried within the protein. A protein involved in Moco insertion and XDH maturation has been identified, which was designated XdhC. XdhC was shown to be essential for the production of active XDH but is not a subunit of the purified enzyme. Here we describe the purification of XdhC and the detailed characterization of its role for XDH maturation. We could show that XdhC binds Moco in stoichiometric amounts, which subsequently can be inserted into Moco-free apo-XDH. A specific interaction between XdhC and XdhB was identified. We show that XdhC is required for the stabilization of the sulfurated form of Moco present in enzymes of the xanthine oxidase family. Our findings imply that enzyme-specific proteins exist for the biogenesis of molybdoenzymes, coordinating Moco binding and insertion into their respective target proteins. So far, the requirement of such proteins for molybdoenzyme maturation has been described only for prokaryotes
Y1  - 2006
UR  - http://www.jbc.org/
U6  - https://doi.org/10.1074/jbc.M601617200
ER  - 
TY  - JOUR
A1  - Beissenhirtz, Moritz Karl
A1  - Scheller, Frieder W.
A1  - Stöcklein, Walter F. M.
A1  - Kurth, D.
A1  - Möhwald, Helmuth
A1  - Lisdat, Fred
T1  - Electroactive cytochrome c multilayers within a polyelectrolyte assembly
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
T1  - Molecule-detective
BT  - Molekül-Detektive : Biosensoren
N2  - Biosensors are analytical devices incorporating biological material (receptor) intimately associated with or integrated within a physicochernical transducer. Advantages are the high selectivity for analyte detection. Examples given comprise the very successful commercial blood glucose biosensors made for the self-control by the diabetic patients. Other biosensors are part of an analytic system, including the sensor chips Of surface plasmon resonance or interferometry based devices, piezoelectric or reflectometric sensors capable of direct measurement of mass changes, and thermometric and other reagentless sensors. The development of nanotubes-based devices allows for significant enhancment of the signal-to-noise ratio of the biosensors. A milestone on the way towards miniaturization and parallelization of biosensors is the recently developed and prize-winning electronic DNA chip
Y1  - 2006
ER  - 
TY  - JOUR
A1  - Liu, Songqin
A1  - Wollenberger, Ursula
A1  - Halamek, Jan
A1  - Leupold, Eik
A1  - Stöcklein, Walter F. M.
A1  - Warsinke, Axel
A1  - Scheller, Frieder W.
T1  - Affinity interaction betwen phenylboronic acid-carrying self-assembled monolayers and FAD or HRP
N2  - A method is provided for the recognition of glycated molecules based on their binding affinities to boronate- carrying monolayers. The affinity interaction of flavin adenine dinucleotide (FAD) and horseradish peroxidase (HRP) with phenylboronic acid monolayers on gold was investigated by using voltammetric and microgravimetric methods. Conjugates of 3-aminopherrylboronic acid and 3,3'-dithiodipropionic acid di(N-hydroxysuccinimide ester) or 11-mercaptoundecanoic acid were prepared and self-assembled on gold surfaces to generate monolayers. FAD is bound to this modified sur-face and recognized by a pair of redox peaks with a formal potential of -0.433 V in a 0.1 m phosphate buffer solution, pH 6.5. Upon addition of a sugar to the buffer, the bound FAD could be replaced, indicating that the binding is reversible. Voltammetric, mass measurements, and photometric activity assays show that the HRP can also be bound to the interface. This binding is reversible, and HRP can be replaced by sorbitol or removed in acidic solution. The effects of pH, incubation time, and concentration of H2O2 were studied by comparing the catalytic reduction of H2O2 in the presence of the electron-donor thionine. The catalytic current of the HRP-loaded electrode was proportional to HRP concentrations in the incubation solution in the range between 5 mu g mL(-1) and 0.4 mg mL(-1) with a linear slope of 3.34 mu A mL mg(-1) and a correlation coefficient of 0.9945
Y1  - 2005
ER  - 
TY  - JOUR
A1  - Kleuser, U.
A1  - Stöcklein, Walter F. M.
A1  - Pieper-Fürst, U.
A1  - Scheller, Frieder W.
T1  - Partikelverstärkte Oberflächenplasmonresonanz für die Quantifizierung von Matrix Metalloproteinase-2
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Pieper-Fürst, U.
A1  - Kleuser, U.
A1  - Stöcklein, Walter F. M.
A1  - Warsinke, Axel
A1  - Scheller, Frieder W.
T1  - Detection of subicomolar concentrations of human matrix metalloproteinase-2 by an optical biosensor
N2  - We describe in this paper the development of a one-step sandwich assay for the highly sensitive and fast detection of human matrix metalloproteinase (MMP)-2 (EC 3.4.24.24), using surface plasmon resonance (SPR). For the assay, two ligands were selected: monoclonal anti-MMP-2 antibody Ab-2 and the tissue inhibitor of metalloproteinases (TIMP)-2. They were chosen on the basis of (1) their affinities to MMP-2, (2) the efficiency of immobilization to the sensor chip, (3) the efficiency of adsorption to colloidal gold, and (4) the stability of these protein-coated gold particles. The assay included mixing of MMP-2 with antibody Ab-2 adsorbed to colloidal gold with a diameter of about 20 rim and injection into the flowcell of the SPR instrument containing immobilized TIMP-2. By using colloidal gold particles an amplification factor of 114 and a detection limit of 0.5 pM for MMP-2 were obtained. The precision of the assay was high even at low analyte concentrations, the standard deviation being 8.3% for five determinations of 1 pM MMP- 2. No significant binding was observed with the structurally related MMP-9. The assay is far more sensitive and faster than commonly used methods for MMP-2 detection. As TIMP-bound MMP-2 is not detected by this method, the assay can be applied for measuring free MMP-2, reflecting the imbalance of free and inhibitor-bound enzyme in various pathological situations. (C) 2004 Elsevier Inc. All rights reserved
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Chen, Jian
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
A1  - Wollenberger, Ursula
T1  - Electrochemical determination of human hemoglobin by using ferrocene carboxylic acid modified carbon powder microelectrode
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Nießner, Reinhard
A1  - Broekaert, J.
A1  - Einax, J. W.
A1  - Scheller, Frieder W.
A1  - Stöcklein, Walter F. M.
T1  - Trendbericht analytische Biochemie 2000/2001
Y1  - 2002
ER  - 
TY  - JOUR
A1  - Öner, Ibrahim Halil
A1  - Querebillo, Christine Joy
A1  - David, Christin
A1  - Gernert, Ulrich
A1  - Walter, Carsten
A1  - Driess, Matthias
A1  - Leimkühler, Silke
A1  - Ly, Khoa Hoang
A1  - Weidinger, Inez M.
T1  - High electromagnetic field enhancement of TiO2 nanotube electrodes
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - We present the fabrication of TiO2 nanotube electrodes with high biocompatibility and extraordinary spectroscopic properties. Intense surface-enhanced resonance Raman signals of the heme unit of the redox enzyme Cytochromeb(5) were observed upon covalent immobilization of the protein matrix on the TiO2 surface, revealing overall preserved structural integrity and redox behavior. The enhancement factor could be rationally controlled by varying the electrode annealing temperature, reaching a record maximum value of over 70 at 475 degrees C. For the first time, such high values are reported for non-directly surface-interacting probes, for which the involvement of charge-transfer processes in signal amplification can be excluded. The origin of the surface enhancement is exclusively attributed to enhanced localized electric fields resulting from the specific optical properties of the nanotubular geometry of the electrode.
KW  - electromagnetic field enhancement
KW  - photonic crystals
KW  - spectro-electrochemistry
KW  - surface-enhanced Raman spectroscopy
KW  - TiO2 nanotubes
Y1  - 2018
U6  - https://doi.org/10.1002/anie.201802597
SN  - 1433-7851
SN  - 1521-3773
VL  - 57
IS  - 24
SP  - 7225
EP  - 7229
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Sass, Stephan
A1  - Stöcklein, Walter F. M.
A1  - Klevesath, Anja
A1  - Hurpin, Jeanne
A1  - Menger, Marcus
A1  - Hille, Carsten
T1  - Binding affinity data of DNA aptamers for therapeutic anthracyclines from microscale thermophoresis and surface plasmon resonance spectroscopy
JF  - The analyst : the analytical journal of the Royal Society of Chemistry
N2  - Anthracyclines like daunorubicin (DRN) and doxorubicin (DOX) play an undisputed key role in cancer treatment, but their chronic administration can cause severe side effects. For precise anthracycline analytical systems, aptamers are preferable recognition elements. Here, we describe the detailed characterisation of a single-stranded DNA aptamer DRN-10 and its truncated versions for DOX and DRN detection. Binding affinities were determined from surface plasmon resonance (SPR) and microscale thermophoresis (MST) and combined with conformational data from circular dichroism (CD). Both aptamers displayed similar nanomolar binding affinities to DRN and DOX, even though their rate constants differed as shown by SPR recordings. SPR kinetic data unravelled a two-state reaction model including a 1 : 1 binding and a subsequent conformational change of the binding complex. This model was supported by CD spectra. In addition, the dissociation constants determined with MST were always lower than that from SPR, and especially for the truncated aptamer they differed by two orders of magnitude. This most probably reflects the methodological difference, namely labelling for MST vs. immobilisation for SPR. From CD recordings, we suggested a specific G-quadruplex as structural basis for anthracycline binding. We concluded that the aptamer DRN-10 is a promising recognition element for anthracycline detection systems and further selected aptamers can be also characterised with the combined methodological approach presented here.
Y1  - 2019
U6  - https://doi.org/10.1039/c9an01247h
SN  - 0003-2654
SN  - 1364-5528
VL  - 144
IS  - 20
SP  - 6064
EP  - 6073
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Zorn, Edgar Ulrich
A1  - Le Corvec, Nicolas
A1  - Varley, Nick R.
A1  - Salzer, Jacqueline T.
A1  - Walter, Thomas R.
A1  - Navarro-Ochoa, Carlos
A1  - Vargas-Bracamontes, Dulce M.
A1  - Thiele, Samuel T.
A1  - Arámbula Mendoza, Raúl
T1  - Load stress controls on directional lava dome growth at Volcan de Colima, Mexico
JF  - Frontiers in Earth Science
N2  - During eruptive activity of andesitic stratovolcanoes, the extrusion of lava domes, their collapse and intermittent explosions are common volcanic hazards. Many lava domes grow in a preferred direction, in turn affecting the direction of lava flows and pyroclastic density currents. Access to active lava domes is difficult and hazardous, so detailed data characterizing lava dome growth are typically limited, keeping the processes controlling the directionality of extrusions unclear. Here we combine TerraSAR-X satellite radar observations with high-resolution airborne photogrammetry to assess morphological changes, and perform finite element modeling to investigate the impact of loading stress on shallow magma ascent directions associated with lava dome extrusion and crater formation at Volcan de Colima, Mexico. The TerraSAR-X data, acquired in similar to 1-m resolution spotlight mode, enable us to derive a chronology of the eruptive processes from intensity-based time-lapse observations of the general crater and dome evolution. The satellite images are complemented by close-range airborne photos, processed by the Structure-from-Motion workflow. This allows the derivation of high-resolution digital elevation models, providing insight into detailed loading and unloading features. During the observation period from Jan-2013 to Feb-2016, we identify a dominantly W-directed dome growth and lava flow production until Jan-2015. In Feb-2015, following the removal of the active summit dome, the surface crater widened and elongated along a NE-SW axis. Later in May-2015, a new dome grew toward the SW of the crater while a separate vent developed in the NE of the crater, reflecting a change in the direction of magma ascent and possible conduit bifurcation. Finite element models show a significant stress change in agreement with the observed magma ascent direction changes in response to the changing surface loads, both for loading (dome growth) and unloading (crater forming excavation) cases. These results allow insight into shallow dome growth dynamics and the migration of magma ascent in response to changing volcano summit morphology. They further highlight the importance of detailed volcano summit morphology surveillance, as changes in direction or location of dome extrusion may have major implications regarding the directions of potential volcanic hazards, such as pyroclastic density currents generated by dome collapse.
KW  - lava dome
KW  - load stress
KW  - Volcan de Colima
KW  - TerraSAR-X
KW  - photogrammetry
KW  - finite element modeling
Y1  - 2019
U6  - https://doi.org/10.3389/feart.2019.00084
SN  - 2296-6463
VL  - 7
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Memczak, Henry
A1  - Lauster, Daniel
A1  - Kar, Parimal
A1  - Di Lella, Santiago
A1  - Volkmer, Rudolf
A1  - Knecht, Volker
A1  - Herrmann, Andreas
A1  - Ehrentreich-Foerster, Eva
A1  - Bier, Frank Fabian
A1  - Stoecklein, Walter F. M.
T1  - Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding
JF  - PLoS one
N2  - Antibodies against spike proteins of influenza are used as a tool for characterization of viruses and therapeutic approaches. However, development, production and quality control of antibodies is expensive and time consuming. To circumvent these difficulties, three peptides were derived from complementarity determining regions of an antibody heavy chain against influenza A spike glycoprotein. Their binding properties were studied experimentally, and by molecular dynamics simulations. Two peptide candidates showed binding to influenza A/Aichi/2/68 H3N2. One of them, termed PeB, with the highest affinity prevented binding to and infection of target cells in the micromolar region without any cytotoxic effect. PeB matches best the conserved receptor binding site of hemagglutinin. PeB bound also to other medical relevant influenza strains, such as human-pathogenic A/California/7/2009 H1N1, and avian-pathogenic A/MuteSwan/Rostock/R901/2006 H7N1. Strategies to improve the affinity and to adapt specificity are discussed and exemplified by a double amino acid substituted peptide, obtained by substitutional analysis. The peptides and their derivatives are of great potential for drug development as well as biosensing.
Y1  - 2016
U6  - https://doi.org/10.1371/journal.pone.0159074
SN  - 1932-6203
VL  - 11
SP  - 82
EP  - 90
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Makower, Alexander
A1  - Bier, Frank Fabian
A1  - Scheller, Frieder W.
T1  - Enzyme sensors and enzyme amplifification systems
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Hovestaedt, Marc
A1  - Memczak, Henry
A1  - Pleiner, Dennis
A1  - Zhang, Xin
A1  - Rappich, Joerg
A1  - Bier, Frank Fabian
A1  - Stöcklein, Walter F. M.
T1  - Characterization of a new maleimido functionalization of gold for surface plasmon resonance spectroscopy
JF  - Journal of molecular recognition : an international journal devoted to research on specific molecular recognition in chemistry, biology, biotechnology and medicine
N2  - Para-maleimidophenyl (p-MP) modified gold surfaces have been prepared by one-step electrochemical deposition and used in surface plasmon resonance (SPR) studies. Therefore, a FITC mimotope peptide (MP1, 12 aa), a human mucin 1 epitope peptide (MUC, 9 aa) and a protein with their specific antibodies were used as model systems. The peptides were modified with an N-terminal cysteine for covalent and directed coupling to the maleimido functionalized surface by means of Michael addition. The coupling yield of the peptide, the binding characteristics of antibody and the unspecific adsorption of the analytes were investigated. The results expand the spectrum of biosensors usable with p-MP by widely used SPR and support its potential to be versatile for several electrochemical and optical biosensors. This allows the combination of an electrochemical and optical read-out for a broad variety of biomolecular interactions on the same chip. Copyright (c) 2014 John Wiley & Sons, Ltd.
KW  - biosensor
KW  - surface plasmon resonance
KW  - diazonium coupling
KW  - maleimidophenyl
KW  - cys-peptide
KW  - aryl diazonium salts
Y1  - 2014
U6  - https://doi.org/10.1002/jmr.2396
SN  - 0952-3499
SN  - 1099-1352
VL  - 27
IS  - 12
SP  - 707
EP  - 713
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Memczak, Henry
A1  - Lauster, Daniel
A1  - Kar, Parimal
A1  - Di Lella, Santiago
A1  - Volkmer, Rudolf
A1  - Knecht, Volker
A1  - Herrmann, Andreas
A1  - Ehrentreich-Förster, Eva
A1  - Bier, Frank Fabian
A1  - Stöcklein, Walter F. M.
T1  - Anti-hemagglutinin antibody derived lead peptides for inhibitors of influenza virus binding
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Antibodies against spike proteins of influenza are used as a tool for characterization of viruses and therapeutic approaches. However, development, production and quality control of antibodies is expensive and time consuming. To circumvent these difficulties, three peptides were derived from complementarity determining regions of an antibody heavy chain against influenza A spike glycoprotein. Their binding properties were studied experimentally, and by molecular dynamics simulations. Two peptide candidates showed binding to influenza A/Aichi/2/68 H3N2. One of them, termed PeB, with the highest affinity prevented binding to and infection of target cells in the micromolar region without any cytotoxic effect. PeB matches best the conserved receptor binding site of hemagglutinin. PeB bound also to other medical relevant influenza strains, such as human-pathogenic A/California/7/2009 H1N1, and avian-pathogenic A/MuteSwan/Rostock/R901/2006 H7N1. Strategies to improve the affinity and to adapt specificity are discussed and exemplified by a double amino acid substituted peptide, obtained by substitutional analysis. The peptides and their derivatives are of great potential for drug development as well as biosensing.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 536 
KW  - receptor-binding
KW  - A viruses
KW  - neutralizing antibody
KW  - avian influenza
KW  - origin
KW  - neuraminidase
KW  - invection
KW  - entry
KW  - sites
KW  - identification
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-410872
SN  - 1866-8372
IS  - 536
ER  - 
TY  - CHAP
A1  - Memczak, Henry
A1  - Lauster, Daniel
A1  - Herrmann, Andreas
A1  - Stöcklein, Walter F. M.
A1  - Bier, Frank Fabian
T1  - Novel hemagglutinin-binding peptides for biosensing and inhibition of Influenza Viruses
T2  - Biopolymers
Y1  - 2013
SN  - 0006-3525
SN  - 1097-0282
VL  - 100
IS  - 3
SP  - 255
EP  - 255
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Warsinke, Axel
A1  - Scheller, Frieder W.
T1  - Organic solvent modified enzyme-liked immunoassay for the detection of triazine herbicides
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
T1  - Enzymes and antibodies in organic media : analytical applications
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Kramer, A.
A1  - Keitel, T.
A1  - Winkler, K.
A1  - Stöcklein, Walter F. M.
A1  - Hühne, Wolfgang
A1  - Schneider-Mergener, Jens
T1  - Molecular basis for the binding promiscuity of an anti-P24 (HIV-1) monoclonal antibody
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Wollenberger, Ursula
A1  - Drungiliene, A.
A1  - Stöcklein, Walter F. M.
A1  - Kulys, J.
A1  - Scheller, Frieder W.
T1  - Direct electrocatalytic determination of dissolved peroxidases
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Scheiner, Ricarda
A1  - Abramson, Charles I.
A1  - Brodschneider, Robert
A1  - Crailsheim, Karl
A1  - Farina, Walter M.
A1  - Fuchs, Stefan
A1  - Grünewald, Bernd
A1  - Hahshold, Sybille
A1  - Karrer, Marlene
A1  - Koeniger, Gudrun
A1  - Königer, Niko
A1  - Menzel, Randolf
A1  - Mujagic, Samir
A1  - Radspieler, Gerald
A1  - Schmickl, Thomas
A1  - Schneider, Christof
A1  - Siegel, Adam J.
A1  - Szopek, Martina
A1  - Thenius, Ronald
T1  - Standard methods for behavioural studies of Apis mellifera
JF  - Journal of apicultural research
N2  - In this BEEBOOK paper we present a set of established methods for quantifying honey bee behaviour. We start with general methods for preparing bees for behavioural assays. Then we introduce assays for quantifying sensory responsiveness to gustatory, visual and olfactory stimuli. Presentation of more complex behaviours like appetitive and aversive learning under controlled laboratory conditions and learning paradigms under free-flying conditions will allow the reader to investigate a large range of cognitive skills in honey bees. Honey bees are very sensitive to changing temperatures. We therefore present experiments which aim at analysing honey bee locomotion in temperature gradients. The complex flight behaviour of honey bees can be investigated under controlled conditions in the laboratory or with sophisticated technologies like harmonic radar or RFID in the field. These methods will be explained in detail in different sections. Honey bees are model organisms in behavioural biology for their complex yet plastic division of labour. To observe the daily behaviour of individual bees in a colony, classical observation hives are very useful. The setting up and use of typical observation hives will be the focus of another section. The honey bee dance language has important characteristics of a real language and has been the focus of numerous studies. We here discuss the background of the honey bee dance language and describe how it can be studied. Finally, the mating of a honey bee queen with drones is essential to survival of the entire colony. We here give detailed and structured information how the mating behaviour of drones and queens can be observed and experimentally manipulated.
 The ultimate goal of this chapter is to provide the reader with a comprehensive set of experimental protocols for detailed studies on all aspects of honey bee behaviour including investigation of pesticide and insecticide effects.
KW  - COLOSS
KW  - BEEBOOK
KW  - honey bee
KW  - behaviour
KW  - gustatory responsiveness
KW  - olfactory responsiveness
KW  - phototaxis
KW  - non-associative learning
KW  - associative learning
KW  - appetitive learning
KW  - aversive learning
KW  - locomotion
KW  - temperature sensing
KW  - honey bee flight
KW  - observation hive
KW  - honey bee dance
KW  - honey bee navigation
KW  - harmonic radar
KW  - BeeScan
KW  - RFID
KW  - honey bee mating
KW  - free-flying honey bees
Y1  - 2013
U6  - https://doi.org/10.3896/IBRA.1.52.4.04
SN  - 0021-8839
SN  - 2078-6913
VL  - 52
IS  - 4
PB  - International Bee Research Association
CY  - Cardiff
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
A1  - Abuknesha, Rhamadan
T1  - Effects of organic solvents on semicontinuous immunochemical detection of coumarin derivatives
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
T1  - Einsatz von Enzymen und Antikörpern in organischen Lösungsmitteln
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Walter, Juliane K.
A1  - Castro, Victor Manuel
A1  - Voss, M.
A1  - Gast, Klaus
A1  - Rueckert, C.
A1  - Piontek, J.
A1  - Blasig, Ingolf E.
T1  - Redox sensitivity of the dimerization of occludin
N2  - Occludin is a self-associating transmembrane tight junction protein affected in oxidative stress. However, its function is unknown. The cytosolic C-terminal tail contains a coiled coil-domain forming dimers contributing to the self- association. Studying the hypothesis that the self-association is redox-sensitive, we found that the dimerization of the domain depended on the sulfhydryl concentration of the environment in low-millimolar range. Under physiological conditions, monomers and dimers were detected. Masking the sulfhydryl residues in the domain prevented the dimerization but affected neither its helical structure nor cylindric shape. Incubation of cell extracts containing full-length occludin with sulfhydryl reagents prevented the dimerization; a cysteine/alanine exchange mutant also did not show dimer formation. This demonstrates, for the first time, that disulfide bridge formation of the domain is involved in the occludin dimerization. It is concluded that the redox-dependent dimerization of occludin may play a regulatory role in the tight junction assembly under physiological and pathological conditions.
Y1  - 2009
UR  - http://www.springerlink.com/content/a0w10t7jgn01lk6h/
SN  - 1420-682X
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Warsinke, Axel
A1  - Micheel, Burkhard
A1  - Höhne, Wolfgang
A1  - Woller, Jochen
A1  - Kempter, Gerhard
A1  - Scheller, Frieder W.
T1  - Characterization of a monoclonal antibody and its Fab fragment against diphenylurea hapten with BIA
Y1  - 1998
SN  - 3-8154-3540-4
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Warsinke, Axel
A1  - Micheel, Burkhard
A1  - Höhne, Wolfgang
A1  - Woller, Jochen
A1  - Kempter, Gerhard
A1  - Scheller, Frieder W.
T1  - Detection of diphenylurea derivatives with biospecific interaction analysis (BIA) : Kinetic investigations
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Jin, Wen
A1  - Bernhardt, Rita
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
T1  - Direct electron transfer of adrenodoxin-a [2Fe-2S] protein-- and its mutants on modified gold electrode
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
T1  - Laccase : a marker enzyme for solvent modified immunoassays
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Halámek, Jan
A1  - Wollenberger, Ursula
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
T1  - Development of a biosensor for glycated hemoglobin
N2  - The development of an electrochemical piezoelectric sensor for the detection of glycated hemoglobin is presented. The total hemoglobin (Hb) content is monitored with a mass-sensitive quartz crystal modified with surfactants, and the glycated fraction of the immobilized Hb is determined by subsequent voltarnmetric measurement of the coupled ferroceneboronic acid. Different modifications of the sensor were tested for their hemoglobin binding ability. Deoxycholate (DOCA) was found to be the most suitable among the examined modifiers. Piezoelectric quartz crystals with gold electrodes were modified with DOCA by covalent binding to a pre-formatted 4-aminothiophenol monolayer. The properties of the Hb binding to DOCA and the pH effect on this interaction were studied. In the proposed assay for glycated hemoglobin at first an Hb sample is incubated with ferroceneboronic acid (FcBA), which binds to the fructosyl residue of the glycated Hb. Then this preincubated Hb sample is allowed to interact with the DOCA-modified piezoelectric quartz crystal. The binding is monitored by quartz crystal nanobalance QCN). The amount of FcBA present on the sensor surface is determined by square wave voltammetry. The binding of FcBA results in well-defined peaks with an EO' of +200 mV versus Ag/AgC1 (1 M KC1). The peak height depends on the degree of glycated Hb in the sample ranging from 0% to 20% of total Hb. The regeneration of the sensing surface is achieved by pepsin digestion of the deposited Hb. Thus the sensor can be re-used more than 30 times.
Y1  - 2007
UR  - http://www.sciencedirect.com/science/journal/00134686
U6  - https://doi.org/10.1016/j.electacta.2007.03.059
SN  - 0013-4686
ER  - 
TY  - JOUR
A1  - Halámek, Jan
A1  - Wollenberger, Ursula
A1  - Stöcklein, Walter F. M.
A1  - Warsinke, Axel
A1  - Scheller, Frieder W.
T1  - Signal amplification in immunoassays using labeling via boronic acid binding to the sugar moiety of immunoglobulin G : proof of concept for glycated hemoglobin
N2  - A novel electrochemical immunoassay based on the multiple affinity labeling of the indicator antibody with an electro-active tag is presented. The concept is illustrated for the determination of the glycated hemoglobin HbA1c in hemoglobin samples. Hemoglobin is adsorbed to the surfactant-modified surface of a piezoelectric quartz crystal. Whereas the quartz crystal nanobalance is used to validate the total Hb binding, the HbA1c on the sensor surface is recognized by an antibody and quantified electrochemically after the sugar moieties of the antibody have been labeled in-situ with ferroceneboronic acid. The sensitivity of this sensor is about threefold higher than the sensitivity of a hemoglobin sensor, where the ferroceneboronic acid is bound directly to HbA1c.
Y1  - 2007
UR  - http://www.informaworld.com/openurl?genre=journal&issn=0003-2719
U6  - https://doi.org/10.1080/00032710701327096
SN  - 0003-2719
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Warsinke, Axel
A1  - Micheel, Burkhard
A1  - Kempter, Gerhard
A1  - Höhne, Wolfgang
A1  - Scheller, Frieder W.
T1  - Diphenylurea hapten sensing with a monoclonal antibody and its Fab fragment : kinetic and thermodynamic investigations
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Wollenberger, Ursula
A1  - Jin, Wen
A1  - Bernhardt, Rita
A1  - Lehmann, Claudia
A1  - Stöcklein, Walter F. M.
A1  - Brigelius-Flohé, Regina
A1  - Scheller, Frieder W.
T1  - Funktionalisierung von Elektroden für den direkten heterogenen Elektrotransfer
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Braune, Steffen
A1  - Walter, M.
A1  - Schulze, F.
A1  - Lendlein, Andreas
A1  - Jung, Friedrich
T1  - Changes in platelet morphology and function during 24 hours of storage
JF  - Clinical hemorheology and microcirculation : blood flow and vessels
N2  - For in vitro studies assessing the interaction of platelets with implant materials, common and standardized protocols for the preparation of platelet rich plasma (PRP) are lacking, which may lead to non-matching results due to the diversity of applied protocols. Particularly, the aging of platelets during prolonged preparation and storage times is discussed to lead to an underestimation of the material thrombogenicity. Here, we study the influence of whole blood-and PRP-storage times on changes in platelet morphology and function.
 Whole blood PFA100 closure times increased after stimulation with collagen/ADP and collagen/epinephrine. Twenty four hours after blood collection, both parameters were prolonged pathologically above the upper limit of the reference range. Numbers of circulating platelets, measured in PRP, decreased after four hours, but no longer after twenty four hours. Mean platelet volumes (MPV) and platelet large cell ratios (P-LCR, 12 fL - 40 fL) decreased over time. Immediately after blood collection, no debris or platelet aggregates could be visualized microscopically. After four hours, first debris and very small aggregates occurred. After 24 hours, platelet aggregates and also debris progressively increased. In accordance to this, the CASY system revealed an increase of platelet aggregates (up to 90 mu m diameter)with increasing storage time.
 The percentage of CD62P positive platelets and PF4 increased significantly with storage time in resting PRP. When soluble ADP was added to stored PRP samples, the number of activatable platelets decreased significantly over storage time. The present study reveals the importance of a consequent standardization in the preparation of WB and PRP. Platelet morphology and function, particularly platelet reactivity to adherent or soluble agonists in their surrounding milieu, changed rapidly outside the vascular system. This knowledge is of crucial interest, particularly in the field of biomaterial development for cardiovascular applications, and may help to define common standards in the in vitro hemocompatibility testing of biomaterials.
KW  - Platelet
KW  - platelet function
KW  - platelet rich plasma
KW  - whole blood
KW  - platelet aging
KW  - platelet storage
KW  - hemocompatibility
KW  - biomaterials
Y1  - 2014
U6  - https://doi.org/10.3233/CH-141876
SN  - 1386-0291
SN  - 1875-8622
VL  - 58
IS  - 1
SP  - 159
EP  - 170
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Martinez-Garcia, Alfredo
A1  - Rosell-Mele, Antoni
A1  - Jaccard, Samuel L.
A1  - Geibert, Walter
A1  - Sigman, Daniel M.
A1  - Haug, Gerald H.
T1  - Southern Ocean dust-climate coupling over the past four million years
JF  - Nature : the international weekly journal of science
N2  - Dust has the potential to modify global climate by influencing the radiative balance of the atmosphere and by supplying iron and other essential limiting micronutrients to the ocean(1,2). Indeed, dust supply to the Southern Ocean increases during ice ages, and 'iron fertilization' of the subantarctic zone may have contributed up to 40 parts per million by volume (p. p. m. v.) of the decrease (80-100 p. p. m. v.) in atmospheric carbon dioxide observed during late Pleistocene glacial cycles(3-7). So far, however, the magnitude of Southern Ocean dust deposition in earlier times and its role in the development and evolution of Pleistocene glacial cycles have remained unclear. Here we report a high-resolution record of dust and iron supply to the Southern Ocean over the past four million years, derived from the analysis of marine sediments from ODP Site 1090, located in the Atlantic sector of the subantarctic zone. The close correspondence of our dust and iron deposition records with Antarctic ice core reconstructions of dust flux covering the past 800,000 years (refs 8, 9) indicates that both of these archives record large-scale deposition changes that should apply to most of the Southern Ocean, validating previous interpretations of the ice core data. The extension of the record beyond the interval covered by the Antarctic ice cores reveals that, in contrast to the relatively gradual intensification of glacial cycles over the past three million years, Southern Ocean dust and iron flux rose sharply at the Mid-Pleistocene climatic transition around 1.25 million years ago. This finding complements previous observations over late Pleistocene glacial cycles(5,8,9), providing new evidence of a tight connection between high dust input to the Southern Ocean and the emergence of the deep glaciations that characterize the past one million years of Earth history.
Y1  - 2011
U6  - https://doi.org/10.1038/nature10310
SN  - 0028-0836
VL  - 476
IS  - 7360
SP  - 312
EP  - U141
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Marcus, Tamar
A1  - Boch, Steffen
A1  - Durka, Walter
A1  - Fischer, Markus
A1  - Gossner, Martin M.
A1  - Müller, Jörg
A1  - Schöning, Ingo
A1  - Weisser, Wolfgang W.
A1  - Drees, Claudia
A1  - Assmann, Thorsten
T1  - Living in Heterogeneous Woodlands - Are Habitat Continuity or Quality Drivers of Genetic Variability in a Flightless Ground Beetle?
JF  - PLoS one
N2  - Although genetic diversity is one of the key components of biodiversity, its drivers are still not fully understood. While it is known that genetic diversity is affected both by environmental parameters as well as habitat history, these factors are not often tested together. Therefore, we analyzed 14 microsatellite loci in Abax parallelepipedus, a flightless, forest dwelling ground beetle, from 88 plots in two study regions in Germany. We modeled the effects of historical and environmental variables on allelic richness, and found for one of the regions, the Schorfheide-Chorin, a significant effect of the depth of the litter layer, which is a main component of habitat quality, and of the sampling effort, which serves as an inverse proxy for local population size. For the other region, the Schwabische Alb, none of the potential drivers showed a significant effect on allelic richness. We conclude that the genetic diversity in our study species is being driven by current local population sizes via environmental variables and not by historical processes in the studied regions. This is also supported by lack of genetic differentiation between local populations sampled from ancient and from recent woodlands. We suggest that the potential effects of former fragmentation and recolonization processes have been mitigated by the large and stable local populations of Abax parallelepipedus in combination with the proximity of the ancient and recent woodlands in the studied landscapes.
Y1  - 2015
U6  - https://doi.org/10.1371/journal.pone.0144217
SN  - 1932-6203
VL  - 10
IS  - 12
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - GEN
A1  - Marcus, Tamar
A1  - Boch, Steffen
A1  - Durka, Walter
A1  - Gossner, Martin M.
A1  - Müller, Jörg
A1  - Schöning, Ingo
A1  - Weisser, Wolfgang W.
A1  - Drees, Claudia
A1  - Assmann, Thorsten
T1  - Living in heterogeneous woodlands
BT  - are habitat continuity or quality drivers of genetic variability in a flightless ground beetle?
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Abstract

Although genetic diversity is one of the key components of biodiversity, its drivers are still not fully understood. While it is known that genetic diversity is affected both by environmental parameters as well as habitat history, these factors are not often tested together. Therefore, we analyzed 14 microsatellite loci in Abax parallelepipedus, a flightless, forest dwelling ground beetle, from 88 plots in two study regions in Germany. We modeled the effects of historical and environmental variables on allelic richness, and found for one of the regions, the Schorfheide-Chorin, a significant effect of the depth of the litter layer, which is a main component of habitat quality, and of the sampling effort, which serves as an inverse proxy for local population size. For the other region, the Schwabische Alb, none of the potential drivers showed a significant effect on allelic richness. We conclude that the genetic diversity in our study species is being driven by current local population sizes via environmental variables and not by historical processes in the studied regions. This is also supported by lack of genetic differentiation between local populations sampled from ancient and from recent woodlands. We suggest that the potential effects of former fragmentation and recolonization processes have been mitigated by the large and stable local populations of Abax parallelepipedus in combination with the proximity of the ancient and recent woodlands in the studied landscapes.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 508 
KW  - forest management intensity
KW  - lichen Lobaria pulmonaria
KW  - past land-use
KW  - carabid beetles
KW  - distribution patterns
KW  - environmental-factors
KW  - conifer plantations
KW  - population-genetics
KW  - species composition
KW  - plant diversity
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-408451
SN  - 1866-8372
IS  - 508
ER  - 
TY  - JOUR
A1  - Stöllner, Daniela
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
A1  - Warsinke, Axel
T1  - Membrane-immobilized haptoglobin as affinity matrix for a hemoglobin-A1c-immunosensor
Y1  - 2002
ER  - 
TY  - JOUR
A1  - Lisdat, Fred
A1  - Utepbergenov, D.
A1  - Haseloff, R. F.
A1  - Blasig, Ingolf E.
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
A1  - Brigelius-Flohé, Regina
T1  - An optical method for the detection of oxidative stress using protein-RNA interaction
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Wolf, C.
A1  - Dye, S.
A1  - Kleinheinrich, M.
A1  - Meisenheimer, Klaus
A1  - Rix, Hans-Walter
A1  - Wisotzki, Lutz
T1  - Deep BVR photometry of the Chandra Deep Field South from the COMBO-17 survey
N2  - We report on deep multi-color imaging (R5sigma = 26) of the Chandra Deep Field South, obtained with the Wide Field Imager (WFI) at the MPG/ESO 2.2 m telescope on La Silla as part of the multi-color survey COMBO-17. As a result we present a catalogue of 63 501 objects in a field measuring 31farcm5 x 30arcmin with astrometry and BVR photometry. A sample of 37 variable objects is selected from two-epoch photometry. We try to give interpretations based on color and variation amplitude.
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
T1  - Biosensoren für die direkte vor-Ort Überwachung von Umwelt-Schadstoffen
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Stöcklein, Walter F. M.
A1  - Behrsing, Olaf
A1  - Scharte, Gudrun
A1  - Micheel, Burkhard
A1  - Benkert, Alexander
A1  - Schössler, W.
A1  - Warsinke, Axel
A1  - Scheller, Frieder W.
T1  - Enzyme kinetic assays with surface plasmon resonance (BIAcore) based on competition between enzyme and creatinine antibody
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Lisdat, Fred
A1  - Ge, Bixia
A1  - Stöcklein, Walter F. M.
A1  - Scheller, Frieder W.
A1  - Meyer, T.
T1  - Electrochemical behaviour and nitric oxides interaction of immobilised cytochrome c from Rhodocyclus gelatinosus
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Wirges, Werner
A1  - Przyrembel, G.
A1  - Brinker, Walter
A1  - Gerhard, Reimund
A1  - Klemberg-Sapieha, J.
A1  - Martinu, L.
A1  - Poitras, D.
A1  - Wertheimer, M. R.
T1  - Metallised viscoelastic control layers for light-valve projection displays
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Eisold, Ursula
A1  - Sellrie, Frank
A1  - Schenk, Jörg A.
A1  - Lenz, Christine
A1  - Stöcklein, Walter F. M.
A1  - Kumke, Michael Uwe
T1  - Bright or dark immune complexes of anti-TAMRA antibodies for adapted fluorescence-based bioanalysis
JF  - Analytical & bioanalytical chemistry
N2  - Fluorescence labels, for example fluorescein or rhodamin derivatives, are widely used in bioanalysis applications including lateral-flow assays, PCR, and fluorescence microscopy. Depending on the layout of the particular application, fluorescence quenching or enhancement may be desired as the detection principle. Especially for multiplexed applications or high-brightness requirements, a tunable fluorescence probe can be beneficial. The alterations in the photophysics of rhodamine derivatives upon binding to two different anti-TAMRA antibodies were investigated by absorption and fluorescence-spectroscopy techniques, especially determining the fluorescence decay time and steady-state and time-resolved fluorescence anisotropy. Two monoclonal anti-TAMRA antibodies were generated by the hybridoma technique. Although surface-plasmon-resonance measurements clearly proved the high affinity of both antibodies towards 5-TAMRA, the observed effects on the fluorescence of rhodamine derivatives were very different. Depending on the anti-TAMRA antibody either a strong fluorescence quenching (G71-DC7) or a distinct fluorescence enhancement (G71-BE11) upon formation of the immune complex was observed. Additional rhodamine derivatives were used to gain further information on the binding interaction. The data reveal that such haptens as 5-TAMRA could generate different paratopes with equal binding affinities but different binding interactions, which provide the opportunity to adapt bioanalysis methods including immunoassays for optimized detection principles for the same hapten depending on the specific requirements.
KW  - mAb
KW  - Fluorescence
KW  - Anisotropy
KW  - Exciplex
KW  - Energy-transfer probe
Y1  - 2015
U6  - https://doi.org/10.1007/s00216-015-8538-0
SN  - 1618-2642
SN  - 1618-2650
VL  - 407
IS  - 12
SP  - 3313
EP  - 3323
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Schenk, Jörg A.
A1  - Sellrie, Frank
A1  - Böttger, Volker
A1  - Micheel, Burkhard
A1  - Stöcklein, Walter F. M.
T1  - Generation and application of a fluorescein-specific single chain antibody
N2  - A recombinant single chain antibody fragment (designated scDE1) of the murine monoclonal anti-fluorescein antibody B13-DE1 was generated using the original hybridoma cells as source for the variable antibody heavy and light chain (VH and VL) genes. After cloning the variable genes into a phage vector a functional antibody fragment was selected by phage display panning. Recombinant antibody could be expressed as phage antibody and as soluble single chain antibody in Escherichia coli. High yield of scDE1 could also be detected in bacterial culture supernatant. The scDE1 showed the same binding specificity as the parental monoclonal antibody, i.e. it bound fluorescein, fluorescein derivatives and a fluorescein peptide mimotope. Surface plasmon resonance revealed a K(D) of 19 nM for the scDE1 compared to 0.7 nM for the monoclonal antibody. The isolated soluble scDE1 could easily be conjugated to horseradish peroxidase which allowed the use of the conjugate as universal indicator for the detection of fluorescein-labelled proteins in different immunoassays. Detection of hCG in urine was performed as a model system using scDE1. In addition to E. coli the scFv genes could also be transferred and expressed in eukaryotic cells. Finally, we generated HEK293 cells expressing the scDE1 at the cell surface.
Y1  - 2007
UR  - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRJ-4P3DY33- 1&_user=1584062&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053886&_version=1&_urlVersion=0&_userid=1584062&md5=e 4
ER  - 
TY  - JOUR
A1  - Bathke, Hannes
A1  - Sudhaus, Henriette
A1  - Holohan, E. P.
A1  - Walter, T. R.
A1  - Shirzaei, M.
T1  - An active ring fault detected at Tendurek volcano by using InSAR
JF  - JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
N2  - Although ring faults are present at many ancient, deeply eroded volcanoes, they have been detected at only very few modern volcanic centers. At the so far little studied Tendurek volcano in eastern Turkey, we generated an ascending and a descending InSAR time series of its surface displacement field for the period from 2003 to 2010. We detected a large (similar to 105km(2)) region that underwent subsidence at the rate of similar to 1cm/yr during this period. Source modeling results show that the observed signal fits best to simulations of a near-horizontal contracting sill located at around 4.5km below the volcano summit. Intriguingly, the residual displacement velocity field contains a steep gradient that systematically follows a system of arcuate fractures visible on the volcano&rsquo;s midflanks. RapidEye satellite optical images show that this fracture system has deflected Holocene lava flows, thus indicating its presence for at least several millennia. We interpret the arcuate fracture system as the surface expression of an inherited ring fault that has been slowly reactivated during the detected recent subsidence. These results show that volcano ring faults may not only slip rapidly during eruptive or intrusive phases, but also slowly during dormant phases.
KW  - Tendurek volcano
KW  - caldera subsidence
KW  - arcuate fracture system
KW  - fault reactivation
Y1  - 2013
U6  - https://doi.org/10.1002/jgrb.50305
SN  - 2169-9313
VL  - 118
IS  - 8
SP  - 4488
EP  - 4502
PB  - AMER GEOPHYSICAL UNION
CY  - WASHINGTON
ER  - 
TY  - JOUR
A1  - Heslop, J. K.
A1  - Anthony, K. M. Walter
A1  - Grosse, Guido
A1  - Liebner, Susanne
A1  - Winkel, Matthias
T1  - Century-scale time since permafrost thaw affects temperature sensitivity of net methane production in thermokarst-lake and talik sediments
JF  - The science of the total environment : an international journal for scientific research into the environment and its relationship with man
N2  - Permafrost thaw subjects previously frozen soil organic carbon (SOC) to microbial degradation to the greenhouse gases carbon dioxide (CO2) and methane (CH4). Emission of these gases constitutes a positive feedback to climate warming. Among numerous uncertainties in estimating the strength of this permafrost carbon feedback (PCF), two are: (i) how mineralization of permafrost SOC thawed in saturated anaerobic conditions responds to changes in temperature and (ii) how microbial communities and temperature sensitivities change over time since thaw. To address these uncertainties, we utilized a thermokarst-lake sediment core as a natural chronosequence where SOC thawed and incubated in situ under saturated anaerobic conditions for up to 400 years following permafrost thaw. Initial microbial communities were characterized, and sediments were anaerobically incubated in the lab at four temperatures (0 °C, 3 °C, 10 °C, and 25 °C) bracketing those observed in the lake's talik. Net CH4 production in freshly-thawed sediments near the downward-expanding thaw boundary at the base of the talik were most sensitive to warming at the lower incubation temperatures (0 °C to 3 °C), while the overlying sediments which had been thawed for centuries had initial low abundant methanogenic communities (< 0.02%) and did not experience statistically significant increases in net CH4 production potentials until higher incubation temperatures (10 °C to 25 °C). We propose these observed differences in temperature sensitivities are due to differences in SOM quality and functional microbial community composition that evolve over time; however further research is necessary to better constrain the roles of these factors in determining temperature controls on anaerobic C mineralization.
KW  - Carbon
KW  - Lake sediments
KW  - Methane
KW  - Permafrost
KW  - Talik
KW  - Temperature sensitivity
Y1  - 2019
U6  - https://doi.org/10.1016/j.scitotenv.2019.06.402
SN  - 0048-9697
SN  - 1879-1026
VL  - 691
SP  - 124
EP  - 134
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Stech, Marlitt
A1  - Merk, Helmut
A1  - Schenk, Jörg A.
A1  - Stöcklein, Walter F. M.
A1  - Wüstenhagen, Doreen Anja
A1  - Micheel, Burkhard
A1  - Duschl, Claus
A1  - Bier, Frank Fabian
A1  - Kubick, Stefan
T1  - Production of functional antibody fragments in a vesicle-based eukaryotic cell-free translation system
JF  - Journal of biotechnology
N2  - Cell-free protein synthesis is of increasing interest for the rapid and high-throughput synthesis of many proteins, in particular also antibody fragments. In this study, we present a novel strategy for the production of single chain antibody fragments (scFv) in a eukaryotic in vitro translation system. This strategy comprises the cell-free expression, isolation and label-free interaction analysis of a model antibody fragment synthesized in two differently prepared insect cell lysates. These lysates contain translocationally active microsomal structures derived from the endoplasmic reticulum (ER), allowing for posttranslational modifications of cell-free synthesized proteins. Both types of these insect cell lysates enable the synthesis and translocation of scFv into ER-derived vesicles. However, only the one that has a specifically adapted redox potential yields functional active antibody fragments. We have developed a new methodology for the isolation of functional target proteins based on the translocation of cell-free produced scFv into microsomal structures and subsequent collection of protein-enriched vesicles. Antibody fragments that have been released from these vesicles are shown to be well suited for label-free binding studies. Altogether, these results show the potential of insect cell lysates for the production, purification and selection of antibody fragments in an easy-to-handle and time-saving manner.
KW  - Cell-free
KW  - In vitro translation
KW  - Single chain antibody (scFv)
KW  - Insect lysate
KW  - Surface plasmon resonance
Y1  - 2012
U6  - https://doi.org/10.1016/j.jbiotec.2012.08.020
SN  - 0168-1656
VL  - 164
IS  - 2
SP  - 220
EP  - 231
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Saritoprak, Zeki
A1  - Vorpahl, Daniel
A1  - Turan, Hakan
A1  - Arslan, Hakki
A1  - Zoref, Arye
A1  - Tarabieh, Abdallah
A1  - Yeshaya, Joachim
A1  - Anzi, Menashe
A1  - Merkur, Lianne
A1  - Schmidt, Daniela
A1  - Schuster, Dirk
A1  - Langer, Armin
A1  - Blum, Rahel
A1  - Stürmann, Jakob
A1  - Pohlmann, Julia
A1  - Schulz, Michael Karl
A1  - Arnold, Rafael D.
A1  - Salzer, Dorothea M.
A1  - Geißler-Grünberg, Anke
A1  - Talabardon, Susanne
A1  - Rasumny, Wiebke
A1  - Stellmacher, Martha
A1  - Denz, Rebekka
A1  - Walter, Simon
A1  - Grözinger, Elvira
ED  - Riemer, Nathanael
ED  - Sanci, Kadir
ED  - Schulz, Michael Karl
T1  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Muslimisch-Jüdischer Dialog
T1  - PaRDeS : Journal of the Association of Jewish Studies = Muslim-Jewish Dialogue
T2  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V.
N2  - PaRDeS. Zeitschrift der Vereinigung für Jüdische Studien e.V., möchte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Berührungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung.
N2  - The journal aims at documenting the fruitful and multifarious culture of Judaism as well as its relations to its environment within diverse areas of research. In addition, the journal is meant to promote Jewish Studies within academic discourse and discuss its historic and social responsibility.
T3  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 22 
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95416
SN  - 978-3-86956-370-1
SN  - 1614-6492
SN  - 1862-7684
IS  - 22
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Nassar, Yomna M.
A1  - Hohmann, Nicolas
A1  - Michelet, Robin
A1  - Gottwalt, Katharina
A1  - Meid, Andreas D.
A1  - Burhenne, Jürgen
A1  - Huisinga, Wilhelm
A1  - Haefeli, Walter E.
A1  - Mikus, Gerd
A1  - Kloft, Charlotte
T1  - Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion
JF  - Clinical Pharmacokinetics
N2  - Background
Cytochrome P450 (CYP) 3A contributes to the metabolism of many approved drugs. CYP3A perpetrator drugs can profoundly alter the exposure of CYP3A substrates. However, effects of such drug-drug interactions are usually reported as maximum effects rather than studied as time-dependent processes. Identification of the time course of CYP3A modulation can provide insight into when significant changes to CYP3A activity occurs, help better design drug-drug interaction studies, and manage drug-drug interactions in clinical practice. 

Objective
We aimed to quantify the time course and extent of the in vivo modulation of different CYP3A perpetrator drugs on hepatic CYP3A activity and distinguish different modulatory mechanisms by their time of onset, using pharmacologically inactive intravenous microgram doses of the CYP3A-specific substrate midazolam, as a marker of CYP3A activity.

Methods
Twenty-four healthy individuals received an intravenous midazolam bolus followed by a continuous infusion for 10 or 36 h. Individuals were randomized into four arms: within each arm, two individuals served as a placebo control and, 2 h after start of the midazolam infusion, four individuals received the CYP3A perpetrator drug: voriconazole (inhibitor, orally or intravenously), rifampicin (inducer, orally), or efavirenz (activator, orally). After midazolam bolus administration, blood samples were taken every hour (rifampicin arm) or every 15 min (remaining study arms) until the end of midazolam infusion. A total of 1858 concentrations were equally divided between midazolam and its metabolite, 1'-hydroxymidazolam. A nonlinear mixed-effects population pharmacokinetic model of both compounds was developed using NONMEM (R). CYP3A activity modulation was quantified over time, as the relative change of midazolam clearance encountered by the perpetrator drug, compared to the corresponding clearance value in the placebo arm. 

Results
Time course of CYP3A modulation and magnitude of maximum effect were identified for each perpetrator drug. While efavirenz CYP3A activation was relatively fast and short, reaching a maximum after approximately 2-3 h, the induction effect of rifampicin could only be observed after 22 h, with a maximum after approximately 28-30 h followed by a steep drop to almost baseline within 1-2 h. In contrast, the inhibitory impact of both oral and intravenous voriconazole was prolonged with a steady inhibition of CYP3A activity followed by a gradual increase in the inhibitory effect until the end of sampling at 8 h. Relative maximum clearance changes were +59.1%, +46.7%, -70.6%, and -61.1% for efavirenz, rifampicin, oral voriconazole, and intravenous voriconazole, respectively.

Conclusions
We could distinguish between different mechanisms of CYP3A modulation by the time of onset. Identification of the time at which clearance significantly changes, per perpetrator drug, can guide the design of an optimal sampling schedule for future drug-drug interaction studies. The impact of a short-term combination of different perpetrator drugs on the paradigm CYP3A substrate midazolam was characterized and can define combination intervals in which no relevant interaction is to be expected.
Y1  - 2022
U6  - https://doi.org/10.1007/s40262-022-01175-6
SN  - 0312-5963
SN  - 1179-1926
VL  - 61
IS  - 11
SP  - 1595
EP  - 1607
PB  - Springer
CY  - Northcote
ER  - 
TY  - JOUR
A1  - Schad, Daniel
A1  - Garbusow, Maria
A1  - Friedel, Eva
A1  - Sommer, Christian
A1  - Sebold, Miriam Hannah
A1  - Hägele, Claudia
A1  - Bernhardt, Nadine
A1  - Nebe, Stephan
A1  - Kuitunen-Paul, Sören
A1  - Liu, Shuyan
A1  - Eichmann, Uta
A1  - Beck, Anne
A1  - Wittchen, Hans-Ulrich
A1  - Walter, Henrik
A1  - Sterzer, Philipp
A1  - Zimmermann, Ulrich S.
A1  - Smolka, Michael N.
A1  - Schlagenhauf, Florian
A1  - Huys, Quentin J. M.
A1  - Heinz, Andreas
A1  - Rapp, Michael Armin
T1  - Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk
JF  - European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry
N2  - The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients (t = -3.86, p < .001), but not in healthy controls (t = -0.92, p = .36). This behavioral inhibition was associated with neural activation in the nucleus accumbens (NAcc) (t((30)) = 2.06, p < .05). Interestingly, both the effects were only present in subsequent abstainers, but not relapsers and in those with mild but not severe dependence. Our data show that alcohol-related cues can acquire inhibitory behavioral features typical of aversive stimuli despite being accompanied by a stronger NAcc activation, suggesting salience attribution. The fact that these findings are restricted to abstinence and milder illness suggests that they may be potential resilience factors.
KW  - Alcohol dependence
KW  - Human neuroimaging
KW  - Nucleus accumbens
KW  - Pavlovian-instrumental transfer
KW  - Relapse
Y1  - 2018
U6  - https://doi.org/10.1007/s00406-017-0860-4
SN  - 0940-1334
SN  - 1433-8491
VL  - 269
IS  - 3
SP  - 295
EP  - 308
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Friedel, Eva
A1  - Sebold, Miriam Hannah
A1  - Kuitunen-Paul, Sören
A1  - Nebe, Stephan
A1  - Veer, Ilya M.
A1  - Zimmermann, Ulrich S.
A1  - Schlagenhauf, Florian
A1  - Smolka, Michael N.
A1  - Rapp, Michael Armin
A1  - Walter, Henrik
A1  - Heinz, Andreas
T1  - How Accumulated Real Life Stress Experience and Cognitive Speed Interact on Decision-Making Processes
JF  - Frontiers in human neuroscienc
N2  - Rationale: Advances in neurocomputational modeling suggest that valuation systems for goal-directed (deliberative) on one side, and habitual (automatic) decision-making on the other side may rely on distinct computational strategies for reinforcement learning, namely model-free vs. model-based learning. As a key theoretical difference, the model-based system strongly demands cognitive functions to plan actions prospectively based on an internal cognitive model of the environment, whereas valuation in the model-free system relies on rather simple learning rules from operant conditioning to retrospectively associate actions with their outcomes and is thus cognitively less demanding. Acute stress reactivity is known to impair model-based but not model-free choice behavior, with higher working memory capacity protecting the model-based system from acute stress. However, it is not clear which impact accumulated real life stress has on model-free and model-based decision systems and how this influence interacts with cognitive abilities. Methods: We used a sequential decision-making task distinguishing relative contributions of both learning strategies to choice behavior, the Social Readjustment Rating Scale questionnaire to assess accumulated real life stress, and the Digit Symbol Substitution Test to test cognitive speed in 95 healthy subjects. Results: Individuals reporting high stress exposure who had low cognitive speed showed reduced model-based but increased model-free behavioral control. In contrast, subjects exposed to accumulated real life stress with high cognitive speed displayed increased model-based performance but reduced model-free control. Conclusion: These findings suggest that accumulated real life stress exposure can enhance reliance on cognitive speed for model-based computations, which may ultimately protect the model-based system from the detrimental influences of accumulated real life stress. The combination of accumulated real life stress exposure and slower information processing capacities, however, might favor model-free strategies. Thus, the valence and preference of either system strongly depends on stressful experiences and individual cognitive capacities.
KW  - chronic stress
KW  - model-based learning
KW  - model-free learning
KW  - decision making
KW  - cognitive speed
KW  - real-life events
Y1  - 2017
U6  - https://doi.org/10.3389/fnhum.2017.00302
SN  - 1662-5161
VL  - 11
SP  - 1
EP  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Flóvenz, Ólafur G.
A1  - Wang, Rongjiang
A1  - Hersir, Gylfi Páll
A1  - Dahm, Torsten
A1  - Hainzl, Sebastian
A1  - Vassileva, Magdalena
A1  - Drouin, Vincent
A1  - Heimann, Sebastian
A1  - Isken, Marius Paul
A1  - Gudnason, Egill Á.
A1  - Ágústsson, Kristján
A1  - Ágústsdóttir, Thorbjörg
A1  - Horálek, Josef
A1  - Motagh, Mahdi
A1  - Walter, Thomas R.
A1  - Rivalta, Eleonora
A1  - Jousset, Philippe
A1  - Krawczyk, Charlotte M.
A1  - Milkereit, Claus
T1  - Cyclical geothermal unrest as a precursor to Iceland's 2021 Fagradalsfjall eruption
JF  - Nature geoscience
N2  - Understanding and constraining the source of geodetic deformation in volcanic areas is an important component of hazard assessment. Here, we analyse deformation and seismicity for one year before the March 2021 Fagradalsfjall eruption in Iceland. We generate a high-resolution catalogue of 39,500 earthquakes using optical cable recordings and develop a poroelastic model to describe three pre-eruptional uplift and subsidence cycles at the Svartsengi geothermal field, 8 km west of the eruption site. We find the observed deformation is best explained by cyclic intrusions into a permeable aquifer by a fluid injected at 4 km depth below the geothermal field, with a total volume of 0.11 ± 0.05 km3 and a density of 850 ± 350 kg m–3. We therefore suggest that ingression of magmatic CO2 can explain the geodetic, gravity and seismic data, although some contribution of magma cannot be excluded.
Y1  - 2022
U6  - https://doi.org/10.1038/s41561-022-00930-5
SN  - 1752-0894
SN  - 1752-0908
VL  - 15
IS  - 5
SP  - 397
EP  - 404
PB  - Nature Research
CY  - Berlin
ER  -