TY - JOUR A1 - Farges, Francois A1 - Djanarthany, S A1 - de Wispelaere, S A1 - Munoz, Manuel A1 - Magassouba, B A1 - Haddi, A A1 - Wilke, Max A1 - Schmidt, C. A1 - Borchert, Manuela A1 - Trocellier, P A1 - Crichton, W A1 - Simionovici, Alexandre A1 - Petit, Pierre-Emanuel A1 - Mezouar, Mohamed A1 - Etcheverry, M. P. A1 - Pallot-Frossard, I A1 - Bargar, John Reeder A1 - Brown, G. E. A1 - Grolimund, D A1 - Scheidegger, A T1 - Water in silicate glasses and melts of environmental interest : from volcanoes to cathedrals N2 - In silicate glasses and melts, water acts according to two main processes. First, it can be dissolved in high temperature/high pressure melts. Second, it constitutes a weathering agent on the glass surface. A number of in-situ x- ray absorption fine structure (XAFS) studies for Fe, Ni, Zr, Th and U show that the more charged cations (Zr, Nb, Mo, Ta, Sn, Th and U) are little affected by the presence of dissolved water in the melt. In contrast, divalent iron and nickel are highly sensitive to the presence of water, which enhance nucleation processes, for example, of phyllosilicates at the angstrom-scale. Such information provides additional constraints on the role of water deep in the Earth, particularly in magmatology. By contrast, the weathering of glass surfaces by water can be studied from a durability perspective. Experimental weathering experiments Of nuclear waste glasses performed in the laboratory show a variety of surface enrichments (carbon, chlorine, alkalis, iron) after exposure to atmospheric fluids and moisture. Mn-, and Fe-surface enrichments of analogous glasses of the XIVth century are related to the formation of Mn and Fe oxy/ hydroxides on the surface. The impact on the glass darkening is considered in terms of urban pollution and mass tourism Y1 - 2005 ER - TY - JOUR A1 - Schmidt, Sabrina A1 - Saxenhofer, Moritz A1 - Drewes, Stephan A1 - Schlegel, Mathias A1 - Wanka, Konrad M. A1 - Frank, Raphael A1 - Klimpel, Sven A1 - von Blanckenhagen, Felix A1 - Maaz, Denny A1 - Herden, Christiane A1 - Freise, Jona A1 - Wolf, Ronny A1 - Stubbe, Michael A1 - Borkenhagen, Peter A1 - Ansorge, Hermann A1 - Eccard, Jana A1 - Lang, Johannes A1 - Jourdain, Elsa A1 - Jacob, Jens A1 - Marianneau, Philippe A1 - Heckel, Gerald A1 - Ulrich, Rainer Günter T1 - High genetic structuring of Tula hantavirus JF - Archives of virology N2 - Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT-PCR and TULV-IgG ELISA. TULV-specific RNA and/or antibodies were detected at 43 of the sites, demonstrating a geographically widespread distribution of the virus in the studied area. The TULV prevalence in common voles (16.7 %) was higher than that in field voles (9.2 %) and water voles (10.0 %). Time series data at ten trapping sites showed evidence of a lasting presence of TULV RNA within common vole populations for up to 34 months, although usually at low prevalence. Phylogenetic analysis demonstrated a strong genetic structuring of TULV sequences according to geography and independent of the rodent species, confirming the common vole as the preferential host, with spillover infections to co-occurring field and water voles. TULV phylogenetic clades showed a general association with evolutionary lineages in the common vole as assessed by mitochondrial DNA sequences on a large geographical scale, but with local-scale discrepancies in the contact areas. Y1 - 2016 U6 - https://doi.org/10.1007/s00705-016-2762-6 SN - 0304-8608 SN - 1432-8798 VL - 161 SP - 1135 EP - 1149 PB - Springer CY - Wien ER - TY - CHAP A1 - Kurbel, Karl A1 - Nowak, Dawid A1 - Azodi, Amir A1 - Jaeger, David A1 - Meinel, Christoph A1 - Cheng, Feng A1 - Sapegin, Andrey A1 - Gawron, Marian A1 - Morelli, Frank A1 - Stahl, Lukas A1 - Kerl, Stefan A1 - Janz, Mariska A1 - Hadaya, Abdulmasih A1 - Ivanov, Ivaylo A1 - Wiese, Lena A1 - Neves, Mariana A1 - Schapranow, Matthieu-Patrick A1 - Fähnrich, Cindy A1 - Feinbube, Frank A1 - Eberhardt, Felix A1 - Hagen, Wieland A1 - Plauth, Max A1 - Herscheid, Lena A1 - Polze, Andreas A1 - Barkowsky, Matthias A1 - Dinger, Henriette A1 - Faber, Lukas A1 - Montenegro, Felix A1 - Czachórski, Tadeusz A1 - Nycz, Monika A1 - Nycz, Tomasz A1 - Baader, Galina A1 - Besner, Veronika A1 - Hecht, Sonja A1 - Schermann, Michael A1 - Krcmar, Helmut A1 - Wiradarma, Timur Pratama A1 - Hentschel, Christian A1 - Sack, Harald A1 - Abramowicz, Witold A1 - Sokolowska, Wioletta A1 - Hossa, Tymoteusz A1 - Opalka, Jakub A1 - Fabisz, Karol A1 - Kubaczyk, Mateusz A1 - Cmil, Milena A1 - Meng, Tianhui A1 - Dadashnia, Sharam A1 - Niesen, Tim A1 - Fettke, Peter A1 - Loos, Peter A1 - Perscheid, Cindy A1 - Schwarz, Christian A1 - Schmidt, Christopher A1 - Scholz, Matthias A1 - Bock, Nikolai A1 - Piller, Gunther A1 - Böhm, Klaus A1 - Norkus, Oliver A1 - Clark, Brian A1 - Friedrich, Björn A1 - Izadpanah, Babak A1 - Merkel, Florian A1 - Schweer, Ilias A1 - Zimak, Alexander A1 - Sauer, Jürgen A1 - Fabian, Benjamin A1 - Tilch, Georg A1 - Müller, David A1 - Plöger, Sabrina A1 - Friedrich, Christoph M. A1 - Engels, Christoph A1 - Amirkhanyan, Aragats A1 - van der Walt, Estée A1 - Eloff, J. H. P. A1 - Scheuermann, Bernd A1 - Weinknecht, Elisa ED - Meinel, Christoph ED - Polze, Andreas ED - Oswald, Gerhard ED - Strotmann, Rolf ED - Seibold, Ulrich ED - Schulzki, Bernhard T1 - HPI Future SOC Lab BT - Proceedings 2015 N2 - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie. Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt. Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor. KW - Future SOC Lab KW - Forschungsprojekte KW - Multicore Architekturen KW - In-Memory Technologie KW - Cloud Computing KW - maschinelles Lernen KW - künstliche Intelligenz Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516 ER - TY - JOUR A1 - Holz, Nathalie E. A1 - Boecker-Schlier, Regina A1 - Buchmann, Arlette F. A1 - Blomeyer, Dorothea A1 - Jennen-Steinmetz, Christine A1 - Baumeister, Sarah A1 - Plichta, Michael M. A1 - Cattrell, Anna A1 - Schumann, Gunter A1 - Esser, Günter A1 - Schmidt, Martin A1 - Buitelaar, Jan A1 - Meyer-Lindenberg, Andreas A1 - Banaschewski, Tobias A1 - Brandeis, Daniel A1 - Laucht, Manfred T1 - Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder JF - Frontiers in human neuroscience N2 - Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2–19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years). CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors. KW - childhood adversity KW - conduct disorder KW - amygdala KW - ventral striatum KW - fMRI Y1 - 2016 U6 - https://doi.org/10.1093/scan/nsw120 SN - 1749-5016 SN - 1749-5024 VL - 12 IS - 2 SP - 261 EP - 272 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - De Biase, Cecilia A1 - Reger, Daniel A1 - Schmidt, Axel A1 - Jechalke, Sven A1 - Reiche, Nils A1 - Martinez-Lavanchy, Paula M. A1 - Rosell, Monica A1 - Van Afferden, Manfred A1 - Maier, Uli A1 - Oswald, Sascha A1 - Thullner, Martin T1 - Treatment of volatile organic contaminants in a vertical flow filter - relevance of different removal processes JF - Ecological engineering : the journal of ecotechnology N2 - Vertical flow filters and vertical flow constructed wetlands are established wastewater treatment systems and have also been proposed for the treatment of contaminated groundwater. This study investigates the removal processes of volatile organic compounds in a pilot-scale vertical flow filter. The filter is intermittently irrigated with contaminated groundwater containing benzene, MTBE and ammonium as the main contaminants. The system is characterized by unsaturated conditions and high contaminant removal efficiency. The aim of the present study is to evaluate the contribution of biodegradation and volatilization to the overall removal of benzene and MTBE. Tracer tests and flow rate measurements showed a highly transient flow and heterogeneous transport regime. Radon-222, naturally occurring in the treated groundwater, was used as a gas tracer and indicated a high volatilization potential. Radon-222 behavior was reproduced by numerical simulations and extrapolated for benzene and MTBE, and indicated these compounds also have a high volatilization potential. In contrast, passive sampler measurements on top of the filter detected only low benzene and MTBE concentrations. Biodegradation potential was evaluated by the analysis of catabolic genes involved in organic compound degradation and a quantitative estimation of biodegradation was derived from stable isotope fractionation analysis. Results suggest that despite the high volatilization potential, biodegradation is the predominant mass removal process in the filter system, which indicates that the volatilized fraction of the contaminants is still subject to subsequent biodegradation. In particular, the upper filter layer located between the injection tubes and the surface of the system might also contribute to biodegradation, and might play a crucial role in avoiding the emission of volatilized contaminants into the atmosphere. KW - Benzene KW - Biodegradation KW - Catabolic genes KW - MTBE KW - Numerical modeling KW - Radon KW - SAFIRA II KW - Stable isotope fractionation analysis KW - Tracers KW - VOCs KW - Volatilization Y1 - 2011 U6 - https://doi.org/10.1016/j.ecoleng.2011.03.023 SN - 0925-8574 VL - 37 IS - 9 SP - 1292 EP - 1303 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Musolff, Andreas A1 - Schmidt, Christian A1 - Rode, Michael A1 - Lischeid, Gunnar A1 - Weise, Stephan M. A1 - Fleckenstein, Jan H. T1 - Groundwater head controls nitrate export from an agricultural lowland catchment JF - Advances in water resources N2 - Solute concentration variability is of fundamental importance for the chemical and ecological state of streams. It is often closely related to discharge variability and can be characterized in terms of a solute export regime. Previous studies, especially in lowland catchments, report that nitrate is often exported with an accretion pattern of increasing concentrations with increasing discharge. Several modeling approaches exist to predict the export regime of solutes from the spatial relationship of discharge generating zones with solute availability in the catchment. For a small agriculturally managed lowland catchment in central Germany, we show that this relationship is controlled by the depth to groundwater table and its temporal dynamics. Principal component analysis of groundwater level time series from wells distributed throughout the catchment allowed derivation of a representative groundwater level time series that explained most of the discharge variability. Groundwater sampling revealed consistently decreasing nitrate concentrations with an increasing thickness of the unsaturated zone. The relationships of depth to groundwater table to discharge and to nitrate concentration were parameterized and integrated to successfully model catchment discharge and nitrate export on the basis of groundwater level variations alone. This study shows that intensive and uniform agricultural land use likely results in a clear and consistent concentration-depth relationship of nitrate, which can be utilized in simple approaches to predict stream nitrate export dynamics at the catchment scale. (C) 2016 Elsevier Ltd. All rights reserved. KW - Water quality KW - Nitrate KW - Lowland catchment KW - Export regime KW - Concentration-discharge relationship Y1 - 2016 U6 - https://doi.org/10.1016/j.advwatres.2016.07.003 SN - 0309-1708 SN - 1872-9657 VL - 96 SP - 95 EP - 107 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Saritoprak, Zeki A1 - Vorpahl, Daniel A1 - Turan, Hakan A1 - Arslan, Hakki A1 - Zoref, Arye A1 - Tarabieh, Abdallah A1 - Yeshaya, Joachim A1 - Anzi, Menashe A1 - Merkur, Lianne A1 - Schmidt, Daniela A1 - Schuster, Dirk A1 - Langer, Armin A1 - Blum, Rahel A1 - Stürmann, Jakob A1 - Pohlmann, Julia A1 - Schulz, Michael Karl A1 - Arnold, Rafael D. A1 - Salzer, Dorothea M. A1 - Geißler-Grünberg, Anke A1 - Talabardon, Susanne A1 - Rasumny, Wiebke A1 - Stellmacher, Martha A1 - Denz, Rebekka A1 - Walter, Simon A1 - Grözinger, Elvira ED - Riemer, Nathanael ED - Sanci, Kadir ED - Schulz, Michael Karl T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Muslimisch-Jüdischer Dialog T1 - PaRDeS : Journal of the Association of Jewish Studies = Muslim-Jewish Dialogue T2 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. N2 - PaRDeS. Zeitschrift der Vereinigung für Jüdische Studien e.V., möchte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Berührungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung. N2 - The journal aims at documenting the fruitful and multifarious culture of Judaism as well as its relations to its environment within diverse areas of research. In addition, the journal is meant to promote Jewish Studies within academic discourse and discuss its historic and social responsibility. T3 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 22 Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95416 SN - 978-3-86956-370-1 SN - 1614-6492 SN - 1862-7684 IS - 22 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Müller-Schöll, A. A1 - Klopp-Schulze, Lena A1 - Huisinga, Wilhelm A1 - Jörger, M. A1 - Neven, P. A1 - Koolen, S. L. A1 - Mathijssen, R. H. J. A1 - Schmidt, S. A1 - Kloft, Charlotte T1 - Patient-tailored tamoxifen dosing based on an increased quantitative understanding of its complex pharmacokinetics: A novel integrative modelling approach T2 - Annals of Oncology Y1 - 2019 SN - 0923-7534 SN - 1569-8041 VL - 30 PB - Oxford Univ. Press CY - Oxford ER - TY - BOOK A1 - Schmidt, Marco A1 - Badtke, Gernot A1 - Bittmann, Frank A1 - Steuer, M. T1 - A new approach for objektive determination of the external spine profile in the sagittal plane Y1 - 1998 ER - TY - JOUR A1 - Kittel, Rene A1 - Misch, K. A1 - Schmidt, M. A1 - Ellwanger, Siegfried A1 - Bittmann, Frank A1 - Badtke, Gernot T1 - Specific effects of boxing on functional parameters of the locomotor system N2 - Problems: Boxer that take part on contests regularly are characterized by high strains on the locomotor system. Especially the area of shoulder girdle and neck can be overused by the fighting posture and standard techniques, that are often associated with non-physiological patterns. Methods: Of 11 young boxers (age 14.6 +/- 0.6 years; 7.3 +/- 0.6 training units per week) and a control group (CG) of 52 male pupils (age 15.4 +/- 0.4 years) the static of head, shoulder girdle, and pelvis was detected by somatoscopy. Additionally, cyclical rotations of the cervical spine were measured using the 3-d-motion recording system CMS70 (Zebris, Germany) and the active range of motion was analysed. Results: In comparison to the CG, head and shoulder of the boxers were ventralised more often (p<0.01). Furthermore, highly significant group differences in the bilateral position of the shoulder heights and the iliac crests were detected in the frontal plane. On average, the active maximal rotation of the boxers was decreased by 17.8 degrees (p = 0.006; d = 0.800). Discussion: Our study was able to detect significant differences in the analysed functional parameters of the locomotor system that may be explained by boxing specific strains and which are prerequisites of optimal performance. As long-term pathologic effects can not be excluded, adequate compensational exercises should be integrated in the training Y1 - 2005 ER - TY - JOUR A1 - Niederhofer, Florian A1 - Cioni, Maria-Rosa L. A1 - Schmidt, Thomas A1 - Bekki, Kenji A1 - de Grijs, Richard A1 - Ivanov, Valentin D. A1 - Oliveira, Joana M. A1 - Ripepi, Vincenzo A1 - Subramanian, Smitha A1 - van Loon, Jacco Th T1 - The VMC survey – XLVI. Stellar proper motions in the centre of the Large Magellanic Cloud JF - Monthly notices of the Royal Astronomical Society N2 - We present proper motion (PM) measurements within the central region of the Large Magellanic Cloud (LMC), using near-infrared data from the VISTA survey of the Magellanic Cloud system (VMC). This work encompasses 18 VMC tiles covering a total sky area of similar to 28 deg(2). We computed absolute stellar PMs from multiepoch observations in the K-s filter over time baselines between similar to 12 and 47 months. Our final catalogue contains similar to 6322 000 likely LMC member stars with derived PMs. We employed a simple flat-rotating disc model to analyse and interpret the PM data. We found a stellar centre of rotation (alpha(0) = 79.95 degrees(+0.22)(-0.23), delta(0) = -69.31 degrees(+0.12)(-0.11)) that is in agreement with that resulting from Hubble Space Telescope data. The inferred viewing angles of the LMC disc (i = 33.5 degrees(+1.2)(-1.3), Theta = 129.8 degrees(+1.9)(-1.9)) are in good agreement with values from the literature but suggest a higher inclination of the central parts of the LMC. Our data confirm a higher rotation amplitude for the young (less than or similar to 0.5 Gyr) stars compared to the intermediate-age/old (greater than or similar to 1 Gyr) population, which can be explained by asymmetric drift. We constructed spatially resolved velocity maps of the intermediate-age/old and young populations. Intermediate-age/old stars follow elongated orbits parallel to the bar's major axis, providing first observational evidence for x(1) orbits within the LMC bar. In the innermost regions, the motions show more chaotic structures. Young stars show motions along a central filamentary bar structure. KW - surveys KW - proper motion KW - stars: kinematics and dynamics KW - galaxies: individual: LMC KW - Magellanic Clouds Y1 - 2022 U6 - https://doi.org/10.1093/mnras/stac712 SN - 0035-8711 SN - 1365-2966 VL - 512 IS - 4 SP - 5423 EP - 5439 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Kaa, Johannes M. A1 - Sternemann, Christian A1 - Appel, Karen A1 - Cerantola, Valerio A1 - Preston, Thomas R. A1 - Albers, Christian A1 - Elbers, Mirko A1 - Libon, Lelia A1 - Makita, Mikako A1 - Pelka, Alexander A1 - Petitgirard, Sylvain A1 - Plückthun, Christian A1 - Roddatis, Vladimir A1 - Sahle, Christoph J. A1 - Spiekermann, Georg A1 - Schmidt, Christian A1 - Schreiber, Anja A1 - Sakrowski, Robin A1 - Tolan, Metin A1 - Wilke, Max A1 - Zastrau, Ulf A1 - Konopkova, Zuzana T1 - Structural and electron spin state changes in an x-ray heated iron carbonate system at the Earth's lower mantle pressures JF - Physical review research N2 - The determination of the spin state of iron-bearing compounds at high pressure and temperature is crucial for our understanding of chemical and physical properties of the deep Earth. Studies on the relationship between the coordination of iron and its electronic spin structure in iron-bearing oxides, silicates, carbonates, iron alloys, and other minerals found in the Earth's mantle and core are scarce because of the technical challenges to simultaneously probe the sample at high pressures and temperatures. We used the unique properties of a pulsed and highly brilliant x-ray free electron laser (XFEL) beam at the High Energy Density (HED) instrument of the European XFEL to x-ray heat and probe samples contained in a diamond anvil cell. We heated and probed with the same x-ray pulse train and simultaneously measured x-ray emission and x-ray diffraction of an FeCO3 sample at a pressure of 51 GPa with up to melting temperatures. We collected spin state sensitive Fe K beta(1,3) fluorescence spectra and detected the sample's structural changes via diffraction, observing the inverse volume collapse across the spin transition. During x-ray heating, the carbonate transforms into orthorhombic Fe4C3O12 and iron oxides. Incipient melting was also observed. This approach to collect information about the electronic state and structural changes from samples contained in a diamond anvil cell at melting temperatures and above will considerably improve our understanding of the structure and dynamics of planetary and exoplanetary interiors. Y1 - 2022 U6 - https://doi.org/10.1103/PhysRevResearch.4.033042 SN - 2643-1564 VL - 4 IS - 3 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Schmidt, Romy A1 - Mieulet, Delphine A1 - Hubberten, Hans-Michael A1 - Obata, Toshihiro A1 - Höfgen, Rainer A1 - Fernie, Alisdair R. A1 - Fisahn, Joachim A1 - Segundo, Blanca San A1 - Guiderdoni, Emmanuel A1 - Schippers, Jos H. M. A1 - Müller-Röber, Bernd T1 - Salt-responsive ERF1 regulates reactive oxygen species-dependent signaling during the initial response to salt stress in rice JF - The plant cell N2 - Early detection of salt stress is vital for plant survival and growth. Still, the molecular processes controlling early salt stress perception and signaling are not fully understood. Here, we identified SALT-RESPONSIVE ERF1 (SERF1), a rice (Oryza sativa) transcription factor (TF) gene that shows a root-specific induction upon salt and hydrogen peroxide (H2O2) treatment. Loss of SERF1 impairs the salt-inducible expression of genes encoding members of a mitogen-activated protein kinase (MAPK) cascade and salt tolerance-mediating TFs. Furthermore, we show that SERF1-dependent genes are H2O2 responsive and demonstrate that SERF1 binds to the promoters of MAPK KINASE KINASE6 (MAP3K6), MAPK5, DEHYDRATION-RESPONSIVE ELEMENT BINDING2A (DREB2A), and ZINC FINGER PROTEIN179 (ZFP179) in vitro and in vivo. SERF1 also directly induces its own gene expression. In addition, SERF1 is a phosphorylation target of MAPK5, resulting in enhanced transcriptional activity of SERF1 toward its direct target genes. In agreement, plants deficient for SERF1 are more sensitive to salt stress compared with the wild type, while constitutive overexpression of SERF1 improves salinity tolerance. We propose that SERF1 amplifies the reactive oxygen species-activated MAPK cascade signal during the initial phase of salt stress and translates the salt-induced signal into an appropriate expressional response resulting in salt tolerance. Y1 - 2013 U6 - https://doi.org/10.1105/tpc.113.113068 SN - 1040-4651 VL - 25 IS - 6 SP - 2115 EP - 2131 PB - American Society of Plant Physiologists CY - Rockville ER - TY - JOUR A1 - Schmidt, Romy A1 - Schippers, Jos H. M. A1 - Mieulet, Delphine A1 - Obata, Toshihiro A1 - Fernie, Alisdair R. A1 - Guiderdoni, Emmanuel A1 - Müller-Röber, Bernd T1 - Multipass, a rice R2R3-type MYB transcription factor, regulates adaptive growth by integrating multiple hormonal pathways JF - The plant journal N2 - Growth regulation is an important aspect of plant adaptation during environmental perturbations. Here, the role of MULTIPASS (OsMPS), an R2R3-type MYB transcription factor of rice, was explored. OsMPS is induced by salt stress and expressed in vegetative and reproductive tissues. Over-expression of OsMPS reduces growth under non-stress conditions, while knockdown plants display increased biomass. OsMPS expression is induced by abscisic acid and cytokinin, but is repressed by auxin, gibberellin and brassinolide. Growth retardation caused by OsMPS over-expression is partially restored by auxin application. Expression profiling revealed that OsMPS negatively regulates the expression of EXPANSIN (EXP) and cell-wall biosynthesis as well as phytohormone signaling genes. Furthermore, the expression of OsMPS-dependent genes is regulated by auxin, cytokinin and abscisic acid. Moreover, we show that OsMPS is a direct upstream regulator of OsEXPA4, OsEXPA8, OsEXPB2, OsEXPB3, OsEXPB6 and the endoglucanase genes OsGLU5 and OsGLU14. The multiple responses of OsMPS and its target genes to various hormones suggest an integrative function of OsMPS in the cross-talk between phytohormones and the environment to regulate adaptive growth. KW - development KW - expansin KW - transcription KW - Oryza sativa KW - hormone KW - abiotic stress Y1 - 2013 U6 - https://doi.org/10.1111/tpj.12286 SN - 0960-7412 SN - 1365-313X VL - 76 IS - 2 SP - 258 EP - 273 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Rothwell, Joseph A. A1 - Murphy, Neil A1 - Aleksandrova, Krasimira A1 - Schulze, Matthias Bernd A1 - Bešević, Jelena A1 - Kliemann, Nathalie A1 - Jenab, Mazda A1 - Ferrari, Pietro A1 - Achaintre, David A1 - Gicquiau, Audrey A1 - Vozar, Béatrice A1 - Scalbert, Augustin A1 - Huybrechts, Inge A1 - Freisling, Heinz A1 - Prehn, Cornelia A1 - Adamski, Jerzy A1 - Cross, Amanda J. A1 - Pala, Valeria Maria A1 - Boutron-Ruault, Marie-Christine A1 - Dahm, Christina C. A1 - Overvad, Kim A1 - Gram, Inger Torhild A1 - Sandanger, Torkjel M. A1 - Skeie, Guri A1 - Jakszyn, Paula A1 - Tsilidis, Kostas K. A1 - Hughes, David J. A1 - van Guelpen, Bethany A1 - Bodén, Stina A1 - Sánchez, Maria-José A1 - Schmidt, Julie A. A1 - Katzke, Verena A1 - Kühn, Tilman A1 - Colorado-Yohar, Sandra A1 - Tumino, Rosario A1 - Bueno-de-Mesquita, Bas A1 - Vineis, Paolo A1 - Masala, Giovanna A1 - Panico, Salvatore A1 - Eriksen, Anne Kirstine A1 - Tjønneland, Anne A1 - Aune, Dagfinn A1 - Weiderpass, Elisabete A1 - Severi, Gianluca A1 - Chajès, Véronique A1 - Gunter, Marc J. T1 - Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort JF - Clinical gastroenterology and hepatology N2 - BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants. CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer. KW - colorectal neoplasm KW - risk factors KW - World Cancer Research Fund/American Institute for Cancer Research Recommendations KW - targeted metabolomics Y1 - 2020 U6 - https://doi.org/10.1016/j.cgh.2020.11.045 SN - 1542-3565 SN - 1542-7714 VL - 20 SP - E1061 EP - E1082 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Laucht, Manfred A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Stöhr, R.-M. A1 - Weindrich, D. A1 - Ihle, Wolfgang A1 - Marcus, A. T1 - Viereinhalb Jahre danach : Mannheimer Risikokinder im Vorschulalter Y1 - 1996 ER - TY - JOUR A1 - Stöhr, R.-M. A1 - Laucht, Manfred A1 - Esser, Günter A1 - Schmidt, Martin H. T1 - Die Geburt eines Geschwisters : Chancen und Risiken für das erstgeborene Kind Y1 - 2000 ER - TY - JOUR A1 - Badtke, Gernot A1 - Bittmann, Frank A1 - Schmidt, Marco A1 - Steuer, M T1 - Ein neues Verfahren zur objektiven Bestimmung der äußeren Wirbelsäulenkurvatur in der Sagittalebene Y1 - 1997 ER -