TY  - JOUR
A1  - Schmidt, Martin H.
A1  - Gerold, M.
A1  - Esser, Günter
T1  - Seelische Gesundheit versus psychische Auffälligkeiten in einer repräsentativen Stichprobe junger Erwachsener
Y1  - 1998
SN  - 3-540-64492-x
ER  - 
TY  - JOUR
A1  - Tiscareno, Matthew S.
A1  - Mitchell, Colin J.
A1  - Murray, Carl D.
A1  - Di Nino, Daiana
A1  - Hedman, Matthew M.
A1  - Schmidt, Jürgen
A1  - Burns, Joseph A.
A1  - Cuzzi, Jeffrey N.
A1  - Porco, Carolyn C.
A1  - Beurle, Kevin
A1  - Evans, Michael W.
T1  - Observations of Ejecta clouds produced by impacts onto Saturn's rings
JF  - Science
N2  - We report observations of dusty clouds in Saturn's rings, which we interpret as resulting from impacts onto the rings that occurred between 1 and 50 hours before the clouds were observed. The largest of these clouds was observed twice; its brightness and cant angle evolved in a manner consistent with this hypothesis. Several arguments suggest that these clouds cannot be due to the primary impact of one solid meteoroid onto the rings, but rather are due to the impact of a compact stream of Saturn-orbiting material derived from previous breakup of a meteoroid. The responsible interplanetary meteoroids were initially between 1 centimeter and several meters in size, and their influx rate is consistent with the sparse prior knowledge of smaller meteoroids in the outer solar system.
Y1  - 2013
U6  - https://doi.org/10.1126/science.1233524
SN  - 0036-8075
VL  - 340
IS  - 6131
SP  - 460
EP  - 464
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Cuzzi, Jeff N.
A1  - Burns, Joseph A.
A1  - Charnoz, Sébastien
A1  - Clark, Roger N.
A1  - Colwell, Josh E.
A1  - Dones, Luke
A1  - Esposito, Larry W.
A1  - Filacchione, Gianrico
A1  - French, Richard G.
A1  - Hedman, Matthew M.
A1  - Kempf, Sascha
A1  - Marouf, Essam A.
A1  - Murray, Carl D.
A1  - Nicholson, Phillip D.
A1  - Porco, Carolyn C.
A1  - Schmidt, Jürgen
A1  - Showalter, Mark R.
A1  - Spilker, Linda J.
A1  - Spitale, Joseph N.
A1  - Srama, Ralf
A1  - Sremcević, Miodrag
A1  - Tiscareno, Matthew Steven
A1  - Weiss, John
T1  - An evolving view of Saturn's dynamic rings
N2  - We review our understanding of Saturn's rings after nearly 6 years of observations by the Cassini spacecraft. Saturn's rings are composed mostly of water ice but also contain an undetermined reddish contaminant. The rings exhibit a range of structure across many spatial scales; some of this involves the interplay of the fluid nature and the self-gravity of innumerable orbiting centimeter- to meter-sized particles, and the effects of several peripheral and embedded moonlets, but much remains unexplained. A few aspects of ring structure change on time scales as short as days. It remains unclear whether the vigorous evolutionary processes to which the rings are subject imply a much younger age than that of the solar system. Processes on view at Saturn have parallels in circumstellar disks.
Y1  - 2010
UR  - http://www.sciencemag.org/
U6  - https://doi.org/10.1126/science.1179118
SN  - 0036-8075
ER  - 
TY  - JOUR
A1  - Jedrusik-Bode, Monika
A1  - Studencka, Maja
A1  - Smolka, Christian
A1  - Baumann, Tobias
A1  - Schmidt, Henning
A1  - Kampf, Jan
A1  - Paap, Franziska
A1  - Martin, Sophie
A1  - Tazi, Jamal
A1  - Müller, Kristian M.
A1  - Krüger, Marcus
A1  - Braun, Thomas
A1  - Bober, Eva
T1  - The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
JF  - Journal of cell science
N2  - SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.
KW  - C. elegans
KW  - G3BP
KW  - SIRT6
KW  - Sirtuins
KW  - Stress
KW  - Stress granules
Y1  - 2013
U6  - https://doi.org/10.1242/jcs.130708
SN  - 0021-9533
SN  - 1477-9137
VL  - 126
IS  - 22
SP  - 5166
EP  - +
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Send, Sebastian
A1  - Abboud, Ali
A1  - Hartmann, Robert
A1  - Huth, M.
A1  - Leitenberger, Wolfram
A1  - Pashniak, N.
A1  - Schmidt, J.
A1  - Strüder, Lothar
A1  - Pietsch, Ullrich
T1  - Characterization of a pnCCD for applications with synchrotron radiation
JF  - Nuclear instruments & methods in physics research : a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics ; A, Accelerators, spectrometers, detectors and associated equipment
N2  - In this work we study the response of a pnCCD by means of X-ray spectroscopy in the energy range between 6 key and 20 key and by Laue diffraction techniques. The analyses include measurements of characteristic detector parameters like energy resolution, count rate capability and effects of different gain settings. The limit of a single photon counting operation in white beam X-ray diffraction experiments is discussed with regard to the occurrence of pile-up events, for which the energy information about individual photons is lost. In case of monochromatic illumination the pnCCD can be used as a fast conventional CCD with a charge handling capacity (CHC) of about 300,000 electrons per pixel. If the CHC is exceeded, any surplus charge will spill to neighboring pixels perpendicular to the transfer direction due to electrostatic repulsion. The possibilities of increasing the number of storable electrons are investigated for different voltage settings by exposing a single pixel with X-rays generated by a microfocus X-ray source. The pixel binning mode is tested as an alternative approach that enables a pnCCD operation with significantly shorter readout times.
KW  - pnCCD
KW  - X-ray spectroscopy
KW  - X-ray imaging
KW  - Energy-dispersive Laue diffraction
Y1  - 2013
U6  - https://doi.org/10.1016/j.nima.2013.01.044
SN  - 0168-9002
VL  - 711
IS  - 5
SP  - 132
EP  - 142
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Gruber, W.
A1  - Chakravarty, S.
A1  - Baehtz, C.
A1  - Leitenberger, Wolfram
A1  - Bruns, M.
A1  - Kobler, A.
A1  - Kübel, Christian
A1  - Schmidt, H.
T1  - Strain relaxation and vacancy creation in thin platinum films
JF  - Physical review letters
N2  - Synchrotron based combined in situ x-ray diffractometry and reflectometry is used to investigate the role of vacancies for the relaxation of residual stress in thin metallic Pt films. From the experimentally determined relative changes of the lattice parameter a and of the film thickness L the modification of vacancy concentration and residual strain was derived as a function of annealing time at 130 degrees C. The results indicate that relaxation of strain resulting from compressive stress is accompanied by the creation of vacancies at the free film surface. This proves experimentally the postulated dominant role of vacancies for stress relaxation in thin metal films close to room temperature.
Y1  - 2011
U6  - https://doi.org/10.1103/PhysRevLett.107.265501
SN  - 0031-9007
VL  - 107
IS  - 26
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Kind, Barbara
A1  - Muster, Britta
A1  - Staroske, Wolfgang
A1  - Herce, Henry D.
A1  - Sachse, Rene
A1  - Rapp, Alexander
A1  - Schmidt, Franziska
A1  - Koss, Sarah
A1  - Cardoso, M. Cristina
A1  - Lee-Kirsch, Min Ae
T1  - Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Goutieres syndrome
JF  - Human molecular genetics
N2  - Ribonuclease H2 plays an essential role for genome stability as it removes ribonucleotides misincorporated into genomic DNA by replicative polymerases and resolves RNA/DNA hybrids. Biallelic mutations in the genes encoding the three RNase H2 subunits cause Aicardi-Goutieres syndrome (AGS), an early-onset inflammatory encephalopathy that phenotypically overlaps with the autoimmune disorder systemic lupus erythematosus. Here we studied the intracellular dynamics of RNase H2 in living cells during DNA replication and in response to DNA damage using confocal time-lapse imaging and fluorescence cross-correlation spectroscopy. We demonstrate that the RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner. RNase H2 is not only recruited to DNA replication foci, but also to sites of PCNA-dependent DNA repair. By fluorescence recovery after photobleaching, we demonstrate a high mobility and fast exchange of RNase H2 at sites of DNA repair and replication. We provide evidence that recruitment of RNase H2 is not only PCNA-dependent, mediated by an interaction of the B subunit with PCNA, but also PCNA-independent mediated via the catalytic domain of the A subunit. We found that AGS-associated mutations alter complex formation, recruitment efficiency and exchange kinetics at sites of DNA replication and repair suggesting that impaired ribonucleotide removal contributes to AGS pathogenesis.
Y1  - 2014
U6  - https://doi.org/10.1093/hmg/ddu319
SN  - 0964-6906
SN  - 1460-2083
VL  - 23
IS  - 22
SP  - 5950
EP  - 5960
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Mueller, K.
A1  - Raila, Jens
A1  - Altenkamp, Rainer
A1  - Schmidt, D.
A1  - Dietrich, R.
A1  - Hurtienne, Andrea
A1  - Wink, M.
A1  - Krone, O.
A1  - Brunnberg, Leo
A1  - Schweigert, Florian J.
T1  - Concentrations of retinol, 3,4-didehydroretinol, and retinyl esters in plasma of free-ranging birds of prey
JF  - Journal of animal physiology and animal nutrition
N2  - This study investigated vitamin A compounds in the plasma of healthy free-ranging Central European raptors with different feeding strategies. Plasma samples of nestlings of white-tailed sea eagle [white-tailed sea eagle (WTSE), Haliaeetus albicilla) (n = 32), osprey (Pandion haliaetus) (n = 39), northern goshawk (Accipiter gentilis) (n = 25), common buzzard (Buteo buteo) (n = 31), and honey buzzard (Pernis apivorus) (n = 18) and adults of WTSE (n = 10), osprey (n = 31), and northern goshawk (n = 45) were investigated with reversed-phase-high-performance liquid chromatography (RP-HPLC). In WTSE, northern goshawks and common buzzards retinol were the main plasma component of vitamin A, whilst in ospreys and honey buzzards, 3,4-didehydroretinol predominated. The median of the retinol plasma concentration in the nestlings group ranged from 0.12 to 3.80 mu M and in the adult group from 0.15 to 6.13 mu M. Median plasma concentrations of 3,4-didehydroretinol in nestlings ranged from 0.06 to 3.55 mu M. In adults, northern goshawks had the lowest plasma concentration of 3,4-didehydroretinol followed by WTSE and ospreys. The plasma of all investigated species contained retinyl esters (palmitate, oleate, and stearate). The results show considerable species-specific differences in the vitamin A plasma concentrations that might be caused by different nutrition strategies.
KW  - birds of prey
KW  - plasma
KW  - retinol
KW  - 3,4-didehydroretinol
KW  - retinyl esters
Y1  - 2012
U6  - https://doi.org/10.1111/j.1439-0396.2011.01219.x
SN  - 0931-2439
VL  - 96
IS  - 6
SP  - 1044
EP  - 1053
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Tobie, G.
A1  - Teanby, N. A.
A1  - Coustenis, A.
A1  - Jaumann, Ralf
A1  - Raulin, E.
A1  - Schmidt, J.
A1  - Carrasco, N.
A1  - Coates, Andrew J.
A1  - Cordier, D.
A1  - De Kok, R.
A1  - Geppert, W. D.
A1  - Lebreton, J. -P.
A1  - Lefevre, A.
A1  - Livengood, T. A.
A1  - Mandt, K. E.
A1  - Mitri, G.
A1  - Nimmo, F.
A1  - Nixon, C. A.
A1  - Norman, L.
A1  - Pappalardo, R. T.
A1  - Postberg, F.
A1  - Rodriguez, S.
A1  - SchuizeMakuch, D.
A1  - Soderblom, J. M.
A1  - Solomonidou, A.
A1  - Stephan, K.
A1  - Stofan, E. R.
A1  - Turtle, E. P.
A1  - Wagner, R. J.
A1  - West, R. A.
A1  - Westlake, J. H.
T1  - Science goals and mission concept for the future exploration of Titan and Enceladus
JF  - Planetary and space science
KW  - Titan
KW  - Enceladus
KW  - Atmosphere
KW  - Surface
KW  - Ocean
KW  - Interior
KW  - Missions
Y1  - 2014
U6  - https://doi.org/10.1016/j.pss.2014.10.002
SN  - 0032-0633
VL  - 104
SP  - 59
EP  - 77
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Holz, Nathalie E.
A1  - Boecker-Schlier, Regina
A1  - Jennen-Steinmetz, Christine
A1  - Buchmann, Arlette F.
A1  - Blomeyer, Dorothea
A1  - Baumeister, Sarah
A1  - Plichta, Michael M.
A1  - Esser, Günter
A1  - Schmidt, Martin
A1  - Meyer-Lindenberg, Andreas
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Positive coping styles and perigenual ACC volume: two related mechanisms for conferring resilience?
JF  - Frontiers in human neuroscience
N2  - Stress exposure has been linked to increased rates of depression and anxiety in adults, particularly in females, and has been associated with maladaptive changes in the anterior cingulate cortex (ACC), which is an important brain structure involved in internalizing disorders. Coping styles are important mediators of the stress reaction by establishing homeostasis, and may thus confer resilience to stress-related psychopathology. Anatomical scans were acquired in 181 healthy participants at age 25 years. Positive coping styles were determined using a self-report questionnaire (German Stress Coping Questionnaire, SVF78) at age 22 years. Adult anxiety and depression symptoms were assessed at ages 22, 23 and 25 years with the Young Adult Self-Report. Information on previous internalizing diagnoses was obtained by diagnostic interview (2-19 years). Positive coping styles were associated with increased ACC volume. ACC volume and positive coping styles predicted anxiety and depression in a sex-dependent manner with increased positive coping and ACC volume being related to lower levels of psychopathology in females, but not in males. These results remained significant when controlled for previous internalizing diagnoses. These findings indicate that positive coping styles and ACC volume are two linked mechanisms, which may serve as protective factors against internalizing disorders.
KW  - coping styles
KW  - perigenual anterior cingulate cortex
KW  - resilience
KW  - anxiety disorders
KW  - mood disorders
Y1  - 2016
U6  - https://doi.org/10.1093/scan/nsw005
SN  - 1749-5016
SN  - 1749-5024
VL  - 11
SP  - 813
EP  - 820
PB  - Oxford Univ. Press
CY  - Oxford
ER  -