TY  - JOUR
A1  - Knoth, Alexander Henning
A1  - Kiy, Alexander
A1  - Müller, Ina
A1  - Klein, Mathias
T1  - Competences in context
BT  - students’ expectations and reflections as guided by the mobile application Reflect.UP
JF  - Technology, knowledge and learning
N2  - Mobile applications are suitable as a structural possibility for students beginning their studies. Using the appReflect.UP,students are encouraged to reflect on the organization, contents, and objectives of their studies. This article focuses on how students can acquire the academic ability to consider their own actions, which is an intrinsic component of academic professionalization. The work examines how a competency framework is derived through study regulations and module descriptions, and how subsequent questions for students' reflection are systematically created using this framework. Next, the hybrid mobile applicationReflect.UPand its underlying software components are introduced, stimulating students' reflections on study content and objectives. The data gathered through the practical use ofReflect.UPis evaluated, and then the ensuing conclusions drawn from students' problems and learning processes for organizing the course of studies are explored. In addition, this paper reflects on the strengths and weaknesses of a mobile application as a sociological and technological compound for structural support of the introductory phase of education.
KW  - introductory phase
KW  - hybrid mobile application
KW  - reflection
KW  - professionalization
KW  - competency framework
Y1  - 2020
U6  - https://doi.org/10.1007/s10758-019-09407-8
SN  - 2211-1662
SN  - 2211-1670
VL  - 25
IS  - 4
SP  - 707
EP  - 731
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - CHAP
A1  - Knoth, Alexander Henning
A1  - Kiy, Alexander
A1  - Müller, Ina
T1  - Das erste Semester von Studierenden der Wirtschafts- und Sozialwissenschaften im Spiegel der Reflect-App
T2  - DeLFI 2016 - Die 14. E-Learning Fachtagung Informatik 11.-14. September 2016 Potsdam
N2  - Mobile Applikationen eignen sich als strukturelle Unterstützungsangebote für Studierende während des Studieneinstiegs. Durch die App Reflect.UP werden Studienorganisation, Studieninhalte und -ziele von Studierenden reflektiert. Der bewusste Umgang mit dem studentischen Kompetenzerwerb als wissenschaftliche    eflexionskompetenz ist immanenter Bestandteil der akademischen Professionalisierung und steht in diesem Beitrag im Vordergrund. Gezeigt wird, wie aus Studienordnungen und Modulbeschreibungen systematisch Fragen zur studentischen Reflexion herausgearbeitet werden und dadurch ein Kompetenzraster entsteht. Die durch den praktischen Einsatz von Reflect.UP gewonnenen Daten werden ausgewertet und dahingehend diskutiert, welche Rückschlüsse sich hieraus auf die Problemlagen und Lernprozesse der Studierenden sowie für die  Studiengangsorganisation(en) ziehen lassen. Darüber hinaus werden die Stärken und Schwächen einer mobilen Applikation als sozial- und informationswissenschaftliches Amalgam zur strukturellen Unterstützung der Studieneingangsphase reflektiert.
KW  - Studieneinstieg
KW  - Studienorganisation
KW  - App
KW  - Reflexion
KW  - Professionalisierung
Y1  - 2016
UR  - http://subs.emis.de/LNI/Proceedings/Proceedings262/article13.html
SN  - 978-3-88579-656-5
IS  - P-262
SP  - 59
EP  - 70
PB  - Gesellschaft für Informatik e.V.
CY  - Bonn
ER  - 
TY  - CHAP
A1  - Kiy, Alexander
A1  - Knoth, Alexander Henning
A1  - Müller, Ina
ED  - Harris-Huemmert, Susan
ED  - Pohlenz, Philipp
ED  - Mitterauer, Lukas
T1  - ReflectUP-App Situative und kontextbezogene Evaluation des Studieneinstiegs
T2  - Digitalisierung der Hochschullehre Neue Anforderungen an die Evaluation?
Y1  - 2018
SN  - 978-3-8309-3807-1
SP  - 85
EP  - 102
PB  - Waxmann
CY  - Münster
ER  - 
TY  - JOUR
A1  - Müller, Jürgen
A1  - Krüger, Jens
A1  - Zeier, Alexander
T1  - Unternehmensportale als Quelle für relevante Informationen
JF  - Handbuch prozessorientierters Wissensmanagment
Y1  - 2014
SN  - 978-3-95545-026-7
SP  - 299
EP  - 307
PB  - GITO
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Srama, Ralf
A1  - Ahrens, Thomas J.
A1  - Altobelli, Nicolas
A1  - Auer, S.
A1  - Bradley, J. G.
A1  - Burton, M.
A1  - Dikarev, V. V.
A1  - Economou, T.
A1  - Fechtig, Hugo
A1  - Görlich, M.
A1  - Grande, M.
A1  - Graps, Amara
A1  - Grün, Eberhard
A1  - Havnes, Ove
A1  - Helfert, Stefan
A1  - Horanyi, Mihaly
A1  - Igenbergs, E.
A1  - Jessberger, Elmar K.
A1  - Johnson, T. V.
A1  - Kempf, Sascha
A1  - Krivov, Alexander v.
A1  - Krüger, Harald
A1  - Mocker-Ahlreep, Anna
A1  - Moragas-Klostermeyer, Georg
A1  - Lamy, Philippe
A1  - Landgraf, Markus
A1  - Linkert, Dietmar
A1  - Linkert, G.
A1  - Lura, F.
A1  - McDonnell, J. A. M.
A1  - Moehlmann, Dirk
A1  - Morfill, Gregory E.
A1  - Muller, M.
A1  - Roy, M.
A1  - Schafer, G.
A1  - Schlotzhauer, G.
A1  - Schwehm, Gerhard H.
A1  - Spahn, Frank
A1  - Stübig, M.
A1  - Svestka, Jiri
A1  - Tschernjawski, V
T1  - The Cassini Cosmic Dust Analyzer
N2  - The Cassini-Huygens Cosmic Dust Analyzer (CDA) is intended to provide direct observations of dust grains with masses between 10(-19) and 10(-9) kg in interplanetary space and in the jovian and saturnian systems, to investigate their physical, chemical and dynamical properties as functions of the distances to the Sun, to Jupiter and to Saturn and its satellites and rings, to study their interaction with the saturnian rings, satellites and magnetosphere. Chemical composition of interplanetary meteoroids will be compared with asteroidal and cometary dust, as well as with Saturn dust, ejecta from rings and satellites. Ring and satellites phenomena which might be effects of meteoroid impacts will be compared with the interplanetary dust environment. Electrical charges of particulate matter in the magnetosphere and its consequences will be studied, e.g. the effects of the ambient plasma and the magnetic held on the trajectories of dust particles as well as fragmentation of particles due to electrostatic disruption. The investigation will be performed with an instrument that measures the mass, composition, electric charge, speed, and flight direction of individual dust particles. It is a highly reliable and versatile instrument with a mass sensitivity 106 times higher than that of the Pioneer 10 and I I dust detectors which measured dust in the saturnian system. The Cosmic Dust Analyzer has significant inheritance from former space instrumentation developed for the VEGA, Giotto, Galileo, and Ulysses missions. It will reliably measure impacts from as low as I impact per month up to 104 impacts per second. The instrument weighs 17 kg and consumes 12 W, the integrated time-of-flight mass spectrometer has a mass resolution of up to 50. The nominal data transmission rate is 524 bits/s and varies between 50 and 4192 bps
Y1  - 2004
SN  - 0038-6308
ER  - 
TY  - JOUR
A1  - Merks, Anne Margarete
A1  - Swinarski, Marie
A1  - Meyer, Alexander Matthias
A1  - Müller, Nicola Victoria
A1  - Özcan, Ismail
A1  - Donat, Stefan
A1  - Burger, Alexa
A1  - Gilbert, Stephen
A1  - Mosimann, Christian
A1  - Abdelilah-Seyfried, Salim
A1  - Panakova, Daniela
T1  - Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
JF  - Nature Communications
N2  - Development of a multiple-chambered heart from the linear heart tube is inherently linked to cardiac looping. Although many molecular factors regulating the process of cardiac chamber ballooning have been identified, the cellular mechanisms underlying the chamber formation remain unclear. Here, we demonstrate that cardiac chambers remodel by cell neighbour exchange of cardiomyocytes guided by the planar cell polarity (PCP) pathway triggered by two non-canonical Wnt ligands, Wnt5b and Wnt11. We find that PCP signalling coordinates the localisation of actomyosin activity, and thus the efficiency of cell neighbour exchange. On a tissue-scale, PCP signalling planar-polarises tissue tension by restricting the actomyosin contractility to the apical membranes of outflow tract cells. The tissue-scale polarisation of actomyosin contractility is required for cardiac looping that occurs concurrently with chamber ballooning. Taken together, our data reveal that instructive PCP signals couple cardiac chamber expansion with cardiac looping through the organ-scale polarisation of actomyosin-based tissue tension.
Y1  - 2018
U6  - https://doi.org/10.1038/s41467-018-04566-1
SN  - 2041-1723
VL  - 9
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Grimm, Christiane
A1  - Meyer, Thomas
A1  - Czapla, Sylvia
A1  - Nikolaus, Jörg
A1  - Scheidt, Holger A.
A1  - Vogel, Alexander
A1  - Herrmann, Andreas
A1  - Wessig, Pablo
A1  - Huster, Daniel
A1  - Müller, Peter
T1  - Structure and dynamics of molecular rods in membranes application of a Spin-Labeled rod
JF  - Chemistry - a European journal
N2  - Molecular rods consisting of a hydrophobic backbone and terminally varying functional groups have been synthesized for applications for the functionalization of membranes. In the present study, we employ a spin-labeled analogue of a recently described new class of molecular rods to characterize their dynamic interactions with membranes. By using the different approaches of ESR and NMR spectroscopy, we show that the spin moiety of the membrane-embedded spin-labeled rod is localized in the upper chain/glycerol region of membranes of different compositions. The rod is embedded within the membrane in a tilted orientation to adjust for the varying hydrophobic thicknesses of these bilayers. This orientation does not perturb the membrane structure. The water solubility of the rod is increased significantly in the presence of certain cyclodextrins. These cyclodextrins also allow the rods to be extracted from the membrane and incorporated into preformed membranes. The latter will improve the future applications of these rods in cellular systems as stable membrane-associated anchors for the functionalization of membrane surfaces.
KW  - hydrophobic mismatch
KW  - membranes
KW  - molecular rods
KW  - phospholipids
KW  - spiro compounds
Y1  - 2013
U6  - https://doi.org/10.1002/chem.201202500
SN  - 0947-6539
VL  - 19
IS  - 8
SP  - 2703
EP  - 2710
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Moser, Othmar
A1  - Tschakert, Gerhard
A1  - Müller, Alexander
A1  - Groeschl, Werner
A1  - Pieber, Thomas R.
A1  - Obermayer-Pietsch, Barbara
A1  - Köhler, Gerd
A1  - Hofmann, Peter
T1  - Effects of High-Intensity Interval Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin
JF  - PLoS one
N2  - Introduction
 We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM).
 Material and Methods
 Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system.
 Results
 BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C.
 Conclusion
 Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM.
Y1  - 2015
U6  - https://doi.org/10.1371/journal.pone.0136489
SN  - 1932-6203
VL  - 10
IS  - 8
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Moser, Othmar
A1  - Tschakert, Gerhard
A1  - Müller, Alexander
A1  - Groeschl, Werner
A1  - Pieber, Thomas R.
A1  - Obermayer-Pietsch, Barbara
A1  - Koehler, Gerd
A1  - Hofmann, Peter
T1  - Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin
JF  - PLoS one
N2  - Introduction

We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM).
Material and Methods

Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/ Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system.
Results

BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C.
Conclusion

Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM.
KW  - Insulin
KW  - Exercise
KW  - Glucose
KW  - Hypoglycemia
KW  - Carbohydrates
KW  - Blood
KW  - Blood sugar
KW  - Heart rate
Y1  - 2015
U6  - https://doi.org/10.1371/journal.pone.0136489
SN  - 1932-6203
VL  - 10
IS  - 8
PB  - Public Library of Science
CY  - Lawrence
ER  - 
TY  - GEN
A1  - Moser, Othmar
A1  - Tschakert, Gerhard
A1  - Müller, Alexander
A1  - Groeschl, Werner
A1  - Pieber, Thomas R.
A1  - Obermayer-Pietsch, Barbara
A1  - Koehler, Gerd
A1  - Hofmann, Peter
T1  - Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin
N2  - Introduction

We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM).
Material and Methods

Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/ Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system.
Results

BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C.
Conclusion

Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 203 
KW  - Blood
KW  - Blood sugar
KW  - Carbohydrates
KW  - Exercise
KW  - Glucose
KW  - Heart rate
KW  - Hypoglycemia
KW  - Insulin
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-82479
ER  - 
TY  - JOUR
A1  - Rauh, Hellgard
A1  - Ziegenhain, Ute
A1  - Müller, Bernd
A1  - Wijnroks, Alexander
T1  - Stability and change in infant-mother attachment in the second year of life : relations to parenting quality and varying degrees of daycare experience
Y1  - 2000
SN  - 0-521-58002-1
ER  - 
TY  - JOUR
A1  - Zien, Alexander
A1  - Rätsch, Gunnar
A1  - Mika, Sebastian
A1  - Schölkopf, Bernhard
A1  - Lengauer, Thomas
A1  - Müller, Klaus-Robert
T1  - Engineering support vector machine kernels that recognize translation initiation sites
Y1  - 2000
SN  - 1367-4803
ER  - 
TY  - JOUR
A1  - Rätsch, Gunnar
A1  - Schölkopf, B.
A1  - Smola, Alexander J.
A1  - Mika, Sebastian
A1  - Onoda, T.
A1  - Müller, Klaus-Robert
T1  - Robust ensemble learning
Y1  - 2000
SN  - 0-262-19448-1
ER  - 
TY  - JOUR
A1  - Rätsch, Gunnar
A1  - Schölkopf, B.
A1  - Smola, Alexander J.
A1  - Müller, Klaus-Robert
A1  - Mika, Sebastian
T1  - V-Arc : ensemble learning in the preence of outliers
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Mika, Sebastian
A1  - Rätsch, Gunnar
A1  - Weston, J.
A1  - Schölkopf, B.
A1  - Smola, Alexander J.
A1  - Müller, Klaus-Robert
T1  - Invariant feature extraction and classification in kernel spaces
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Rätsch, Gunnar
A1  - Schölkopf, B.
A1  - Smola, Alexander J.
A1  - Mika, Sebastian
A1  - Onoda, T.
A1  - Müller, Klaus-Robert
T1  - Robust ensemble learning for data analysis
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Banks, Jo Ann
A1  - Nishiyama, Tomoaki
A1  - Hasebe, Mitsuyasu
A1  - Bowman, John L.
A1  - Gribskov, Michael
A1  - dePamphilis, Claude
A1  - Albert, Victor A.
A1  - Aono, Naoki
A1  - Aoyama, Tsuyoshi
A1  - Ambrose, Barbara A.
A1  - Ashton, Neil W.
A1  - Axtell, Michael J.
A1  - Barker, Elizabeth
A1  - Barker, Michael S.
A1  - Bennetzen, Jeffrey L.
A1  - Bonawitz, Nicholas D.
A1  - Chapple, Clint
A1  - Cheng, Chaoyang
A1  - Correa, Luiz Gustavo Guedes
A1  - Dacre, Michael
A1  - DeBarry, Jeremy
A1  - Dreyer, Ingo
A1  - Elias, Marek
A1  - Engstrom, Eric M.
A1  - Estelle, Mark
A1  - Feng, Liang
A1  - Finet, Cedric
A1  - Floyd, Sandra K.
A1  - Frommer, Wolf B.
A1  - Fujita, Tomomichi
A1  - Gramzow, Lydia
A1  - Gutensohn, Michael
A1  - Harholt, Jesper
A1  - Hattori, Mitsuru
A1  - Heyl, Alexander
A1  - Hirai, Tadayoshi
A1  - Hiwatashi, Yuji
A1  - Ishikawa, Masaki
A1  - Iwata, Mineko
A1  - Karol, Kenneth G.
A1  - Koehler, Barbara
A1  - Kolukisaoglu, Uener
A1  - Kubo, Minoru
A1  - Kurata, Tetsuya
A1  - Lalonde, Sylvie
A1  - Li, Kejie
A1  - Li, Ying
A1  - Litt, Amy
A1  - Lyons, Eric
A1  - Manning, Gerard
A1  - Maruyama, Takeshi
A1  - Michael, Todd P.
A1  - Mikami, Koji
A1  - Miyazaki, Saori
A1  - Morinaga, Shin-ichi
A1  - Murata, Takashi
A1  - Müller-Röber, Bernd
A1  - Nelson, David R.
A1  - Obara, Mari
A1  - Oguri, Yasuko
A1  - Olmstead, Richard G.
A1  - Onodera, Naoko
A1  - Petersen, Bent Larsen
A1  - Pils, Birgit
A1  - Prigge, Michael
A1  - Rensing, Stefan A.
A1  - Mauricio Riano-Pachon, Diego
A1  - Roberts, Alison W.
A1  - Sato, Yoshikatsu
A1  - Scheller, Henrik Vibe
A1  - Schulz, Burkhard
A1  - Schulz, Christian
A1  - Shakirov, Eugene V.
A1  - Shibagaki, Nakako
A1  - Shinohara, Naoki
A1  - Shippen, Dorothy E.
A1  - Sorensen, Iben
A1  - Sotooka, Ryo
A1  - Sugimoto, Nagisa
A1  - Sugita, Mamoru
A1  - Sumikawa, Naomi
A1  - Tanurdzic, Milos
A1  - Theissen, Guenter
A1  - Ulvskov, Peter
A1  - Wakazuki, Sachiko
A1  - Weng, Jing-Ke
A1  - Willats, William W. G. T.
A1  - Wipf, Daniel
A1  - Wolf, Paul G.
A1  - Yang, Lixing
A1  - Zimmer, Andreas D.
A1  - Zhu, Qihui
A1  - Mitros, Therese
A1  - Hellsten, Uffe
A1  - Loque, Dominique
A1  - Otillar, Robert
A1  - Salamov, Asaf
A1  - Schmutz, Jeremy
A1  - Shapiro, Harris
A1  - Lindquist, Erika
A1  - Lucas, Susan
A1  - Rokhsar, Daniel
A1  - Grigoriev, Igor V.
T1  - The selaginella genome identifies genetic changes associated with the evolution of vascular plants
JF  - Science
N2  - Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.
Y1  - 2011
U6  - https://doi.org/10.1126/science.1203810
SN  - 0036-8075
VL  - 332
IS  - 6032
SP  - 960
EP  - 963
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - GEN
A1  - Merks, Anne Margarete
A1  - Swinarski, Marie
A1  - Meyer, Alexander Matthias
A1  - Müller, Nicola Victoria
A1  - Özcan, Ismail
A1  - Donat, Stefan
A1  - Burger, Alexa
A1  - Gilbert, Stephen
A1  - Mosimann, Christian
A1  - Abdelilah-Seyfried, Salim
A1  - Panáková, Daniela
T1  - Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
T2  - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
N2  - Development of a multiple-chambered heart from the linear heart tube is inherently linked to cardiac looping. Although many molecular factors regulating the process of cardiac chamber ballooning have been identified, the cellular mechanisms underlying the chamber formation remain unclear. Here, we demonstrate that cardiac chambers remodel by cell neighbour exchange of cardiomyocytes guided by the planar cell polarity (PCP) pathway triggered by two non-canonical Wnt ligands, Wnt5b and Wnt11. We find that PCP signalling coordinates the localisation of actomyosin activity, and thus the efficiency of cell neighbour exchange. On a tissue-scale, PCP signalling planar-polarises tissue tension by restricting the actomyosin contractility to the apical membranes of outflow tract cells. The tissue-scale polarisation of actomyosin contractility is required for cardiac looping that occurs concurrently with chamber ballooning. Taken together, our data reveal that instructive PCP signals couple cardiac chamber expansion with cardiac looping through the organ-scale polarisation of actomyosin-based tissue tension.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 849 
KW  - convergent extension
KW  - branching morphogenesis
KW  - actin cytoskeleton
KW  - zebrafish heart
KW  - mouse heart
KW  - drosophila
KW  - cadherin
KW  - gene
KW  - differentiation
KW  - proliferation
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427026
SN  - 1866-8372
IS  - 849
ER  - 
TY  - JOUR
A1  - Zech, Christina
A1  - Stein, Monika
A1  - Haberer, Anke
A1  - Böhne, Alexander
A1  - Müller-Röber, Bernd
A1  - Heinig, Angela
A1  - Raehse, Sebastian
T1  - Portal = Existenzgründung: Ein Sprung ins kalte Wasser
BT  - Die Potsdamer Universitätszeitung
N2  - Aus dem Inhalt:
Existenzgründung: Ein Sprung ins kalte Wasser
-Bernd Walz über Wettbewerbsfähigkeit und Nachwuchsförderung 
-Gertrud Lehnert über Mode bei Marcel Proust 
-Juniorprofessor Jens Eisert über Quanteninformation
T3  - Portal: Das Potsdamer Universitätsmagazin - 03-04/2003 
Y1  - 2003
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-501536
SN  - 1618-6893
VL  - 2003
ER  -