TY  - JOUR
A1  - Paz, Cristian
A1  - Peter, Martin G.
A1  - Schmidt, Bernd
A1  - Becerra, Jose
A1  - Gutierrez, Margarita
A1  - Astudillo, Luis
A1  - Silva, Mario
T1  - Synthesis and AChE inhibiting activity of 2, 4 substituted 6-Phenyl Pyrimidines
JF  - Journal of the Chilean Chemical Society
N2  - Novel substituted pyrimidines were synthesized from methyl 2,4-dioxo-4-phenyl-butanoate (I-A) and urea, followed by Mitsunobu coupling of I-A with benzyl or allyl alcohol to give the corresponding 2-hydroxypyrimidine ethers in good yields. Saponification of I-A, followed by reaction with benzyl or allyl amines in the presence of TBTU yielded 2-hydroxy-6-phenyl-pyrimidine 4-carboxamides. AChE and BuChE assays revealed 2-hydroxy-6-phenyl-pyrimidine-4-carboxyallyamide as the most active compound, IC50=90 mu M, with no inhibition of BuChE.
KW  - Pyrimidines
KW  - inhibition AChE
KW  - mitsunobu
KW  - TBTU
Y1  - 2012
SN  - 0717-9324
VL  - 57
IS  - 3
SP  - 1292
EP  - 1294
PB  - Sociedad Chilena De Quimica
CY  - Concepcion
ER  - 
TY  - JOUR
A1  - Astudillo-Sotomayor, Luis
A1  - Jara Muñoz, Julius
A1  - Melnick, Daniel
A1  - Cortés‐Aranda, Joaquín
A1  - Tassara, Andrés
A1  - Strecker, Manfred
T1  - Fast Holocene slip and localized strain along the Liquiñe-Ofqui strike-slip fault system, Chile
JF  - Scientific reports
N2  - In active tectonic settings dominated by strike-slip kinematics, slip partitioning across subparallel faults is a common feature; therefore, assessing the degree of partitioning and strain localization is paramount for seismic hazard assessments. Here, we estimate a slip rate of 18.8 +/- 2.0 mm/year over the past 9.0 +/- 0.1 ka for a single strand of the Liquirie-Ofqui Fault System, which straddles the Main Cordillera in Southern Chile. This Holocene rate accounts for similar to 82% of the trench-parallel component of oblique plate convergence and is similar to million-year estimates integrated over the entire fault system. Our results imply that strain localizes on a single fault at millennial time scale but over longer time scales strain localization is not sustained. The fast millennial slip rate in the absence of historical Mw> 6.5 earthquakes along the Liquine-Ofqui Fault System implies either a component of aseismic slip or Mw similar to 7 earthquakes involving multi-trace ruptures and > 150-year repeat times. Our results have implications for the understanding of strike-slip fault system dynamics within volcanic arcs and seismic hazard assessments.
KW  - Geodynamics
KW  - Geomorphology
KW  - Tectonics
Y1  - 2021
U6  - https://doi.org/10.1038/s41598-021-85036-5
SN  - 2045-2322
VL  - 11
IS  - 1
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - London
ER  -