TY  - THES
A1  - Lu, Dandan
T1  - ROS transcriptional networks controlling cell expansion during leaf growth in Arabidopsis thaliana
Y1  - 2012
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Schippers, Jos H. M.
A1  - Nguyen, Hung M.
A1  - Lu, Dandan
A1  - Schmidt, Romy
A1  - Müller-Röber, Bernd
T1  - ROS homeostasis during development: an evolutionary conserved strategy
JF  - Cellular and molecular life sciences
N2  - The balance between cellular proliferation and differentiation is a key aspect of development in multicellular organisms. Recent studies on Arabidopsis roots revealed distinct roles for different reactive oxygen species (ROS) in these processes. Modulation of the balance between ROS in proliferating cells and elongating cells is controlled at least in part at the transcriptional level. The effect of ROS on proliferation and differentiation is not specific for plants but appears to be conserved between prokaryotic and eukaryotic life forms. The ways in which ROS is received and how it affects cellular functioning is discussed from an evolutionary point of view. The different redox-sensing mechanisms that evolved ultimately result in the activation of gene regulatory networks that control cellular fate and decision-making. This review highlights the potential common origin of ROS sensing, indicating that organisms evolved similar strategies for utilizing ROS during development, and discusses ROS as an ancient universal developmental regulator.
KW  - Evolution
KW  - Reactive oxygen species
KW  - Development
Y1  - 2012
U6  - https://doi.org/10.1007/s00018-012-1092-4
SN  - 1420-682X
VL  - 69
IS  - 19
SP  - 3245
EP  - 3257
PB  - Springer
CY  - Basel
ER  - 
TY  - JOUR
A1  - Lu, Dandan
A1  - Wang, Ting
A1  - Persson, Staffan
A1  - Müller-Röber, Bernd
A1  - Schippers, Jos H. M.
T1  - Transcriptional control of ROS homeostasis by KUODA1 regulates cell expansion during leaf development
JF  - Nature Communications
N2  - The final size of an organism, or of single organs within an organism, depends on an intricate coordination of cell proliferation and cell expansion. Although organism size is of fundamental importance, the molecular and genetic mechanisms that control it remain far from understood. Here we identify a transcription factor, KUODA1 (KUA1), which specifically controls cell expansion during leaf development in Arabidopsis thaliana. We show that KUA1 expression is circadian regulated and depends on an intact clock. Furthermore, KUA1 directly represses the expression of a set of genes encoding for peroxidases that control reactive oxygen species (ROS) homeostasis in the apoplast. Disruption of KUA1 results in increased peroxidase activity and smaller leaf cells. Chemical or genetic interference with the ROS balance or peroxidase activity affects cell size in a manner consistent with the identified KUA1 function. Thus, KUA1 modulates leaf cell expansion and final organ size by controlling ROS homeostasis.
Y1  - 2014
U6  - https://doi.org/10.1038/ncomms4767
SN  - 2041-1723
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  -