TY  - JOUR
A1  - Wolf, Thomas J. A.
A1  - Sanchez, David M.
A1  - Yang, J.
A1  - Parrish, R. M.
A1  - Nunes, J. P. F.
A1  - Centurion, M.
A1  - Coffee, R.
A1  - Cryan, J. P.
A1  - Gühr, Markus
A1  - Hegazy, Kareem
A1  - Kirrander, Adam
A1  - Li, R. K.
A1  - Ruddock, J.
A1  - Shen, Xiaozhe
A1  - Vecchione, T.
A1  - Weathersby, S. P.
A1  - Weber, Peter M.
A1  - Wilkin, K.
A1  - Yong, Haiwang
A1  - Zheng, Q.
A1  - Wang, X. J.
A1  - Minitti, Michael P.
A1  - Martinez, Todd J.
T1  - The photochemical ring-opening of 1,3-cyclohexadiene imaged by ultrafast electron diffraction
JF  - Nature chemistry
N2  - The ultrafast photoinduced ring-opening of 1,3-cyclohexadiene constitutes a textbook example of electrocyclic reactions in organic chemistry and a model for photobiological reactions in vitamin D synthesis. Although the relaxation from the photoexcited electronic state during the ring-opening has been investigated in numerous studies, the accompanying changes in atomic distance have not been resolved. Here we present a direct and unambiguous observation of the ring-opening reaction path on the femtosecond timescale and subangstrom length scale using megaelectronvolt ultrafast electron diffraction. We followed the carbon-carbon bond dissociation and the structural opening of the 1,3-cyclohexadiene ring by the direct measurement of time-dependent changes in the distribution of interatomic distances. We observed a substantial acceleration of the ring-opening motion after internal conversion to the ground state due to a steepening of the electronic potential gradient towards the product minima. The ring-opening motion transforms into rotation of the terminal ethylene groups in the photoproduct 1,3,5-hexatriene on the subpicosecond timescale.
KW  - Organic chemistry
KW  - Photochemistry
KW  - Physical chemistry
KW  - Theoretical chemistry
Y1  - 2019
U6  - https://doi.org/10.1038/s41557-019-0252-7
SN  - 1755-4330
SN  - 1755-4349
VL  - 11
IS  - 6
SP  - 504
EP  - 509
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Wang, Xiaoxi
A1  - Foster, William J.
A1  - Yan, J.
A1  - Li, A.
A1  - Mutti, Maria
T1  - Delayed recovery of metazoan reefs on the Laibin-Heshan platform margin following the Middle Permian (Capitanian) mass extinction
JF  - Global and planetary change
N2  - Following the Middle Permian (Capitanian) mass extinction there was a global ‘reef eclipse’, and this event had an important role in the Paleozoic-Mesozoic transition of reef ecosystems. Furthermore, the recovery pattern of reef ecosystems in the Wuchiapingian of South China, before the radiation of Changhsingian reefs, is poorly understood. Here, we present a detailed sedimentological account of the Tieqiao section, South China, which records the only known Wuchiapingian reef setting from South China. Six reef growing phases were identified within six transgressive-regressive cycles. The cycles represent changes of deposition in a shallow basin to a subtidal outer platform setting, and the reefal build-ups are recorded in the shallowest part of the cycles above wave base in the euphotic zone. Our results show that the initial reef recovery started from the shallowing up part of the 1st cycle, within the Clarkina leveni conodont zone, which is two conodont zones earlier than previously recognized. In addition, even though metazoans, such as sponges, do become important in the development of the reef bodies, they are not a major component until later in the Wuchiapingian in the 5th and 6th transgressive-regressive cycles. This suggests a delayed recovery of metazoan reef ecosystems following the Middle Permian extinction. Furthermore, even though sponges do become abundant within the reefs, it is the presence and growth of the encrusters Archaeolithoporella and Tubiphytes and abundance of microbial micrites that play an important role in stabilizing the reef structures that form topographic highs.
KW  - Reefs
KW  - Mass extinction
KW  - Wuchiapingian
KW  - Archaeolithoporella
KW  - Permian
Y1  - 2019
U6  - https://doi.org/10.1016/j.gloplacha.2019.05.005
SN  - 0921-8181
SN  - 1872-6364
VL  - 180
SP  - 1
EP  - 15
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Chapman, Eric M.
A1  - Lant, Benjamin
A1  - Ohashi, Yota
A1  - Yu, Bin
A1  - Schertzberg, Michael
A1  - Go, Christopher
A1  - Dogra, Deepika
A1  - Koskimaki, Janne
A1  - Girard, Romuald
A1  - Li, Yan
A1  - Fraser, Andrew G.
A1  - Awad, Issam A.
A1  - Abdelilah-Seyfried, Salim
A1  - Gingras, Anne-Claude
A1  - Derry, William Brent
T1  - A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
JF  - Nature Communications
N2  - Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease.
Y1  - 2019
U6  - https://doi.org/10.1038/s41467-019-09829-z
SN  - 2041-1723
VL  - 10
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Li, Chen
A1  - Stoma, Svetlana
A1  - Lotta, Luca A.
A1  - Warner, Sophie
A1  - Albrecht, Eva
A1  - Allione, Alessandra
A1  - Arp, Pascal P.
A1  - Broer, Linda
A1  - Buxton, Jessica L.
A1  - Boeing, Heiner
A1  - Langenberg, Claudia
A1  - Codd, Veryan
T1  - Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1 , PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1205 
KW  - Mendelian randomization
KW  - risk
KW  - variants
KW  - disease
KW  - cancer
KW  - loci
KW  - database
KW  - genes
KW  - heart
KW  - gwas
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-526843
SN  - 1866-8372
IS  - 3
ER  - 
TY  - JOUR
A1  - Li, Junbai
A1  - Miller, Reinhard
A1  - Wüstneck, Rainer
A1  - Möhwald, Helmuth
A1  - Neumann, A. W.
T1  - News of pendant drop technique as a film balance at liquid/liquid interfaces
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Miller, Reinhard
A1  - Li, Junbai
A1  - Wüstneck, Rainer
A1  - Krägel, Jürgen
A1  - Clark, David C.
A1  - Neumann, Wilhelm A.
T1  - Pendant drop technique for studies of dynamic properties of soluble adsorption layers and insoluble monolayers
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Kumar, Pankaj
A1  - Gale, Stephan W.
A1  - Kocyan, Alexander
A1  - Fischer, Gunter A.
A1  - Averyanov, Leonid
A1  - Borosova, Renata
A1  - Bhattacharjee, Avishek
A1  - Li, Ji-Hong
A1  - Pang, Kuen Shum
T1  - Gastrochilus kadooriei (Orchidaceae), a new species from Hong Kong, with notes on allied taxa in section Microphyllae found in the region
JF  - Phytotaxa : a rapid international journal for accelerating the publication of botanical taxonomy
N2  - A new species, Gastrochilus kadooriei, is described from Hong Kong. Notes are presented on its distribution, ecology and conservation status, and its distinguishing features are compared with those of allied taxa. Gastrochilus jeitouensis is reduced to the synonymy of G. distichus, and a lectotype is assigned for G. pseudodistichus. Gastrochilus fuscopunctatus is reinstated as an accepted species. Dichotomous keys to this taxonomically difficult group of morphologically similar species are presented.
Y1  - 2014
SN  - 1179-3155
SN  - 1179-3163
VL  - 164
IS  - 2
SP  - 91
EP  - 103
PB  - Magnolia Press
CY  - Auckland
ER  - 
TY  - JOUR
A1  - Krägel, Jürgen
A1  - Wüstneck, Rainer
A1  - Husband, Fiona
A1  - Wilde, Peter J.
A1  - Makievski, A. V.
A1  - Grigoriev, D. O.
A1  - Li, Junbai
T1  - Properties of mixed protein/surfactant adsorption layers
Y1  - 1999
SN  - 0927-7765
ER  - 
TY  - JOUR
A1  - Thompson, Jessica A.
A1  - Chen, Jie
A1  - Yang, Huili
A1  - Li, Tao
A1  - Bookhagen, Bodo
A1  - Burbank, Douglas
T1  - Coarse- versus fine-grain quartz OSL and cosmogenic Be-10 dating of deformed fluvial terraces on the northeast Pamir margin, northwest China
JF  - Quaternary geochronology : the international research and review journal on advances in quaternary dating techniques
N2  - Along the NE Pamir margin, flights of late Quaternary fluvial terraces span actively deforming fault-related folds. We present detailed results on two terraces dated using optically stimulated luminescence (OSL) and cosmogenic radionuclide Be-10 (CRN) techniques. Quartz OSL dating of two different grain sizes (4-11 mu m and 90-180 mu m) revealed the fine-grain quartz fraction may overestimate the terrace ages by up to a factor of ten. Two-mm, small-aliquot, coarse-grain quartz OSL ages, calculated using the minimum age model, yielded stratigraphically consistent ages within error and dated times of terrace deposition to similar to 9 and similar to 16 ka. We speculate that, in this arid environment, fine-grain samples can be transported and deposited in single, turbid, and (sometimes) night-time floods that prevent thorough bleaching and, thereby, can lead to relatively large residual OSL signals. In contrast, sand in the fluvial system is likely to have a much longer residence time during transport, thereby providing greater opportunities for thorough bleaching. CRN Be-10 depth profiles date the timing of terrace abandonment to similar to 8 and similar to 14 ka: ages that generally agree with the coarse-grain quartz OSL ages. Our new terrace age of similar to 13-14 ka is broadly consistent with other terraces in the region that indicate terrace deposition and subsequent abandonment occurred primarily during glacial-interglacial transitions, thereby suggesting a climatic control on the formation of these terraces on the margins of the Tarim Basin. Furthermore, tectonic shortening rates calculated from these deformed terraces range from similar to 1.2 to similar to 4.6 mm/a and, when combined with shortening rates from other structures in the region, illuminate the late Quaternary basinward migration of deformation to faults and folds along the Pamir-Tian Shan collisional interface.
KW  - Tectonic geomorphology
KW  - Deformation
KW  - Quaternary terraces
KW  - Pamir
KW  - Tian shan
Y1  - 2018
U6  - https://doi.org/10.1016/j.quageo.2018.01.002
SN  - 1871-1014
SN  - 1878-0350
VL  - 46
SP  - 1
EP  - 15
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Thompson, Jessica A.
A1  - Burbank, Douglas W.
A1  - Li, Tao
A1  - Chen, Jie
A1  - Bookhagen, Bodo
T1  - Late Miocene northward propagation of the northeast Pamir thrust system, northwest China
JF  - Tectonics
N2  - Piggyback basins on the margins of growing orogens commonly serve as sensitive recorders of the onset of thrust deformation and changes in source areas. The Bieertuokuoyi piggyback basin, located in the hanging wall of the Pamir Frontal Thrust, provides an unambiguous record of the outward growth of the northeast Pamir margin in northwest China from the Miocene through the Quaternary. To reconstruct the deformation along the margin, we synthesized structural mapping, stratigraphy, magnetostratigraphy, and cosmogenic burial dating of basin fill and growth strata. The Bieertuokuoyi basin records the initiation of the Pamir Frontal Thrust and the Takegai Thrust similar to 5-6Ma, as well as clast provenance and paleocurrent changes resulting from the Pliocene-to-Recent uplift and exhumation of the Pamir to the south. Our results show that coeval deformation was accommodated on the major structures on the northeast Pamir margin throughout the Miocene to Recent. Furthermore, our data support a change in the regional kinematics around the Miocene-Pliocene boundary (similar to 5-6Ma). Rapid exhumation of NE Pamir extensional domes, coupled with cessation of the Kashgar-Yecheng Transfer System on the eastern margin of the Pamir, accelerated the outward propagation of the northeastern Pamir margin and the southward propagation of the Kashi-Atushi fold-and-thrust belt in the southern Tian Shan. This coeval deformation signifies the coupling of the Pamir and Tarim blocks and the transfer of shortening north to the Pamir frontal faults and across the quasi-rigid Tarim Basin to the southern Tian Shan Kashi-Atushi fold-and-thrust system.
KW  - Pamir
KW  - thrust tectonics
KW  - piggyback basin
KW  - growth strata
KW  - landscape evolution
KW  - cosmogenic burial dating
Y1  - 2015
U6  - https://doi.org/10.1002/2014TC003690
SN  - 0278-7407
SN  - 1944-9194
VL  - 34
IS  - 3
SP  - 510
EP  - 534
PB  - American Geophysical Union
CY  - Washington
ER  -