TY  - JOUR
A1  - Omosa, Leonidah K.
A1  - Amugune, Beatrice
A1  - Ndunda, Beth
A1  - Milugo, Trizah K.
A1  - Heydenreich, Matthias
A1  - Yenesew, Abiy
A1  - Midiwo, Jacob O.
T1  - Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia
JF  - South African journal of botany : an international interdisciplinary journal for botanical sciences
KW  - Dodonaea angustifolia
KW  - Surface exudates
KW  - Flavone
KW  - Flavanone
KW  - Diterpenoid
KW  - Antimicrobial activities
Y1  - 2014
U6  - https://doi.org/10.1016/j.sajb.2013.11.012
SN  - 0254-6299
SN  - 1727-9321
VL  - 91
SP  - 58
EP  - 62
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Muiva-Mutisya, Lois
A1  - Macharia, Bernard
A1  - Heydenreich, Matthias
A1  - Koch, Andreas
A1  - Akala, Hoseah M.
A1  - Derese, Solomon
A1  - Omosa, Leonidah K.
A1  - Yusuf, Amir O.
A1  - Kamau, Edwin
A1  - Yenesew, Abiy
T1  - 6 alpha-Hydroxy-alpha-toxicarol and (+)-tephrodin with antiplasmodial activities from Tephrosia species
JF  - Phytochemistry letters
N2  - The CH2Cl2/MeOH (1: 1) extract of the roots of Tephrosia villosa showed good antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 3.1 +/- 0.4 and 1.3 +/- 0.3 mu g/mL, respectively. Chromatographic separation of the extract yielded a new rotenoid, 6 alpha-hydroxy-alpha-toxicarol, along with five known rotenoids, (rotenone, deguelin, sumatrol, 12 alpha-hydroxy-alpha-toxicarol and villosinol). Similar treatment of the extract of the stem of Tephrosia purpurea (IC50 = 4.1 +/- 0.4 and 1.9 +/- 0.2 mu g/mL against D6 and W2 strains of P. falciparum, respectively) yielded a new flavone having a unique substituent at C-7/C-8 [trivial name (+)-tephrodin], along with the known flavonoids tachrosin, obovatin methyl ether and derrone. The relative configuration and the most stable conformation in (+)-tephrodin was determined by NMR and theoretical energy calculations. The rotenoids and flavones tested showed good to moderate antiplasmodial activities (IC50 = 9 +/- 23 mu M). Whereas the cytotoxicity of rotenoids is known, the flavones (+)-tephrodin and tachrosin did not show significant cytotoxicity (IC50 > 100 mu M;) against mammalian African monkey kidney (vero) and human larynx carcinoma (HEp2) cell lines. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
KW  - Tephrosia villosa
KW  - Tephrosia purpurea
KW  - 6 alpha-Hydroxy-alpha-toxicarol
KW  - (+)-Tephrodin
KW  - Plasmodium falciparum
Y1  - 2014
U6  - https://doi.org/10.1016/j.phytol.2014.09.002
SN  - 1874-3900
SN  - 1876-7486
VL  - 10
SP  - 179
EP  - 183
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kerubo, Leonidah Omosa
A1  - Midiwo, Jacob Ogweno
A1  - Derese, Solomon
A1  - Langat, Moses K.
A1  - Akala, Hoseah M.
A1  - Waters, Norman C.
A1  - Peter, Martin
A1  - Heydenreich, Matthias
T1  - Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus
JF  - Natural product communications : an international journal for communications and reviews
N2  - From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
KW  - Senecio roseiflorus
KW  - Asteraceae
KW  - Surface exudates
KW  - Antiplasmodial activity
Y1  - 2013
SN  - 1934-578X
VL  - 8
IS  - 2
SP  - 175
EP  - 176
PB  - NPC
CY  - Westerville
ER  -