TY - JOUR A1 - Jedrusik-Bode, Monika A1 - Studencka, Maja A1 - Smolka, Christian A1 - Baumann, Tobias A1 - Schmidt, Henning A1 - Kampf, Jan A1 - Paap, Franziska A1 - Martin, Sophie A1 - Tazi, Jamal A1 - Müller, Kristian M. A1 - Krüger, Marcus A1 - Braun, Thomas A1 - Bober, Eva T1 - The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals JF - Journal of cell science N2 - SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress. KW - C. elegans KW - G3BP KW - SIRT6 KW - Sirtuins KW - Stress KW - Stress granules Y1 - 2013 U6 - https://doi.org/10.1242/jcs.130708 SN - 0021-9533 SN - 1477-9137 VL - 126 IS - 22 SP - 5166 EP - + PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Darcy, Isabelle A1 - Krüger, Franziska T1 - Vowel perception and production in Turkish children acquiring L2 German JF - Journal of phonetics N2 - First language (L1) phonological categories strongly influence late learners' perception and production of second language (L2) categories. For learners who start learning an L2 early in life ("early learners"), this L1 influence appears to be substantially reduced or at least more variable. In this paper, we examine the age at which L1 vowel categories influence the acquisition of L2 vowels. We tested a child population with a very narrow range of age of first exposure, controlling for the use of L1 vs. L2, and various naturally produced contrasts that are not allophonic in the L1 of the children. An oddity discrimination task provided evidence that children who are native speakers of Turkish and began learning German as an L2 in kindergarten categorized difficult German contrasts differently from age-matched native speakers. Their vowel productions of these same contrasts (un-cued object naming) were mostly target-like. Y1 - 2012 U6 - https://doi.org/10.1016/j.wocn.2012.05.001 SN - 0095-4470 VL - 40 IS - 4 SP - 568 EP - 581 PB - Elsevier CY - London ER - TY - JOUR A1 - Preusse, Franziska A1 - van der Meer, Elke A1 - Deshpande, Gopikrishna A1 - Krüger, Frank A1 - Wartenburger, Isabell T1 - Fluid intelligence allows flexible recruitment of the parieto-frontal network in analogical reasoning JF - Frontiers in human neuroscienc N2 - Fluid intelligence is the ability to think flexibly and to understand abstract relations. People with high fluid intelligence (hi-fluIQ) perform better in analogical reasoning tasks than people with average fluid intelligence (ave-fluIQ). Although previous neuroimaging studies reported involvement of parietal and frontal brain regions in geometric analogical reasoning (which is a prototypical task for fluid intelligence), however, neuroimaging findings on geometric analogical reasoning in hi-fluIQ are sparse. Furthermore, evidence on the relation between brain activation and intelligence while solving cognitive tasks is contradictory. The present study was designed to elucidate the cerebral correlates of geometric analogical reasoning in a sample of hi-fluIQ and ave-fluIQ high school students. We employed a geometric analogical reasoning task with graded levels of task difficulty and confirmed the involvement of the parieto-frontal network in solving this task. In addition to characterizing the brain regions involved in geometric analogical reasoning in hi-fluIQ and ave-fluIQ, we found that blood oxygenation level dependency (BOLD) signal changes were greater for hi-fluIQ than for ave-fluIQ in parietal brain regions. However, ave-fluIQ showed greater BOLD signal changes in the anterior cingulate cortex and medial frontal gyrus than hi-fluIQ. Thus, we showed that a similar network of brain regions is involved in geometric analogical reasoning in both groups. Interestingly, the relation between brain activation and intelligence is not mono-directional, but rather, it is specific for each brain region. The negative brain activation-intelligence relationship in frontal brain regions in hi-fluIQ goes along with a better behavioral performance and reflects a lower demand for executive monitoring compared to ave-fluIQ individuals. In conclusion, our data indicate that flexibly modulating the extent of regional cerebral activity is characteristic for fluid intelligence. KW - high fluid intelligence KW - geometric analogical reasoning KW - task difficulty KW - functional magnetic resonance imaging KW - parieto-frontal network Y1 - 2011 U6 - https://doi.org/10.3389/fnhum.2011.00022 SN - 1662-5161 VL - 5 IS - 3 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Lohwaßer, Roswitha A1 - Wendland, Mirko A1 - Reinhardt, Felix A1 - Halibrand, Katharina A1 - Deiseroth, Laura A1 - Jennek, Julia A1 - Strobel, Anne A1 - Hackel, Manuela A1 - Krüger, Sophie A1 - Fischer, Tom A1 - Bosse, Stefanie A1 - Florian, Lena A1 - Fabian, Melina A1 - Israel, Franziska A1 - Iffert, Mathias A1 - Hintze, Ksenia A1 - Wendland, Mirko A1 - Egbert, Björn A1 - Heinz, Sarah A1 - Bock, Sophia A1 - Mutschler, Tanja A1 - Burchard, Daniel A1 - Musil, Andreas T1 - Kentron : Journal zur Lehrerbildung = AHA Moment T3 - Kentron : Journal zur Lehrerbildung - 35 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-590429 SN - 1867-4720 SN - 1867-4747 IS - 35 PB - Universität Potsdam, Zentrum für Lehrerbildung CY - Potsdam ER -