TY  - JOUR
A1  - Koehler, Friedrich
A1  - Koehler, Kerstin
A1  - Deckwart, Oliver
A1  - Prescher, Sandra
A1  - Wegscheider, Karl
A1  - Winkler, Sebastian
A1  - Vettorazzi, Eik
A1  - Polze, Andreas
A1  - Stangl, Karl
A1  - Hartmann, Oliver
A1  - Marx, Almuth
A1  - Neuhaus, Petra
A1  - Scherf, Michael
A1  - Kirwan, Bridget-Anne
A1  - Anker, Stefan D.
T1  - Telemedical Interventional Management in Heart Failure II (TIM-HF2), a randomised, controlled trial investigating the impact of telemedicine on unplanned cardiovascular hospitalisations and mortality in heart failure patients
BT  - study design and description of the intervention
JF  - European Journal of Heart Failure
N2  - Background Heart failure (HF) is a complex, chronic condition that is associated with debilitating symptoms, all of which necessitate close follow-up by health care providers. Lack of disease monitoring may result in increased mortality and more frequent hospital readmissions for decompensated HF. Remote patient management (RPM) in this patient population may help to detect early signs and symptoms of cardiac decompensation, thus enabling a prompt initiation of the appropriate treatment and care before a manifestation of HF decompensation. Objective The objective of the present article is to describe the design of a new trial investigating the impact of RPM on unplanned cardiovascular hospitalisations and mortality in HF patients. Methods The TIM-HF2 trial is designed as a prospective, randomised, controlled, parallel group, open (with randomisation concealment), multicentre trial with pragmatic elements introduced for data collection. Eligible patients with HF are randomised (1:1) to either RPM + usual care or to usual care only and are followed for 12 months. The primary outcome is the percentage of days lost due to unplanned cardiovascular hospitalisations or all-cause death. The main secondary outcomes are all-cause and cardiovascular mortality. Conclusion The TIM-HF2 trial will provide important prospective data on the potential beneficial effect of telemedical monitoring and RPM on unplanned cardiovascular hospitalisations and mortality in HF patients.
KW  - Chronic heart failure
KW  - Telemonitoring
KW  - Remote patient management
KW  - Hospitalisation
Y1  - 2018
U6  - https://doi.org/10.1002/ejhf.1300
SN  - 1388-9842
SN  - 1879-0844
VL  - 20
IS  - 10
SP  - 1485
EP  - 1493
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Koehler, Andreas
A1  - Ohrnberger, Matthias
A1  - Scherbaum, Frank
T1  - Unsupervised feature selection and general pattern discovery using Self-Organizing Maps for gaining insights into the nature of seismic wavefields
N2  - This study presents an unsupervised feature selection and learning approach for the discovery and intuitive imaging of significant temporal patterns in seismic single-station or network recordings. For this purpose, the data are parametrized by real-valued feature vectors for short time windows using standard analysis tools for seismic data, such as frequency-wavenumber, polarization, and spectral analysis. We use Self-Organizing Maps (SOMs) for a data-driven feature selection, visualization and clustering procedure, which is in particular suitable for high-dimensional data sets. Our feature selection method is based on significance testing using the Wald-Wolfowitz runs test for-individual features and on correlation hunting with SOMs in feature subsets. Using synthetics composed of Rayleigh and Love waves and real-world data, we show the robustness and the improved discriminative power of that approach compared to feature subsets manually selected from individual wavefield parametrization methods. Furthermore, the capability of the clustering and visualization techniques to investigate the discrimination of wave phases is shown by means of synthetic waveforms and regional earthquake recordings.
Y1  - 2009
UR  - http://www.sciencedirect.com/science/journal/00983004
U6  - https://doi.org/10.1016/j.cageo.2009.02.004
SN  - 0098-3004
ER  - 
TY  - JOUR
A1  - Banks, Jo Ann
A1  - Nishiyama, Tomoaki
A1  - Hasebe, Mitsuyasu
A1  - Bowman, John L.
A1  - Gribskov, Michael
A1  - dePamphilis, Claude
A1  - Albert, Victor A.
A1  - Aono, Naoki
A1  - Aoyama, Tsuyoshi
A1  - Ambrose, Barbara A.
A1  - Ashton, Neil W.
A1  - Axtell, Michael J.
A1  - Barker, Elizabeth
A1  - Barker, Michael S.
A1  - Bennetzen, Jeffrey L.
A1  - Bonawitz, Nicholas D.
A1  - Chapple, Clint
A1  - Cheng, Chaoyang
A1  - Correa, Luiz Gustavo Guedes
A1  - Dacre, Michael
A1  - DeBarry, Jeremy
A1  - Dreyer, Ingo
A1  - Elias, Marek
A1  - Engstrom, Eric M.
A1  - Estelle, Mark
A1  - Feng, Liang
A1  - Finet, Cedric
A1  - Floyd, Sandra K.
A1  - Frommer, Wolf B.
A1  - Fujita, Tomomichi
A1  - Gramzow, Lydia
A1  - Gutensohn, Michael
A1  - Harholt, Jesper
A1  - Hattori, Mitsuru
A1  - Heyl, Alexander
A1  - Hirai, Tadayoshi
A1  - Hiwatashi, Yuji
A1  - Ishikawa, Masaki
A1  - Iwata, Mineko
A1  - Karol, Kenneth G.
A1  - Koehler, Barbara
A1  - Kolukisaoglu, Uener
A1  - Kubo, Minoru
A1  - Kurata, Tetsuya
A1  - Lalonde, Sylvie
A1  - Li, Kejie
A1  - Li, Ying
A1  - Litt, Amy
A1  - Lyons, Eric
A1  - Manning, Gerard
A1  - Maruyama, Takeshi
A1  - Michael, Todd P.
A1  - Mikami, Koji
A1  - Miyazaki, Saori
A1  - Morinaga, Shin-ichi
A1  - Murata, Takashi
A1  - Müller-Röber, Bernd
A1  - Nelson, David R.
A1  - Obara, Mari
A1  - Oguri, Yasuko
A1  - Olmstead, Richard G.
A1  - Onodera, Naoko
A1  - Petersen, Bent Larsen
A1  - Pils, Birgit
A1  - Prigge, Michael
A1  - Rensing, Stefan A.
A1  - Mauricio Riano-Pachon, Diego
A1  - Roberts, Alison W.
A1  - Sato, Yoshikatsu
A1  - Scheller, Henrik Vibe
A1  - Schulz, Burkhard
A1  - Schulz, Christian
A1  - Shakirov, Eugene V.
A1  - Shibagaki, Nakako
A1  - Shinohara, Naoki
A1  - Shippen, Dorothy E.
A1  - Sorensen, Iben
A1  - Sotooka, Ryo
A1  - Sugimoto, Nagisa
A1  - Sugita, Mamoru
A1  - Sumikawa, Naomi
A1  - Tanurdzic, Milos
A1  - Theissen, Guenter
A1  - Ulvskov, Peter
A1  - Wakazuki, Sachiko
A1  - Weng, Jing-Ke
A1  - Willats, William W. G. T.
A1  - Wipf, Daniel
A1  - Wolf, Paul G.
A1  - Yang, Lixing
A1  - Zimmer, Andreas D.
A1  - Zhu, Qihui
A1  - Mitros, Therese
A1  - Hellsten, Uffe
A1  - Loque, Dominique
A1  - Otillar, Robert
A1  - Salamov, Asaf
A1  - Schmutz, Jeremy
A1  - Shapiro, Harris
A1  - Lindquist, Erika
A1  - Lucas, Susan
A1  - Rokhsar, Daniel
A1  - Grigoriev, Igor V.
T1  - The selaginella genome identifies genetic changes associated with the evolution of vascular plants
JF  - Science
N2  - Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.
Y1  - 2011
U6  - https://doi.org/10.1126/science.1203810
SN  - 0036-8075
VL  - 332
IS  - 6032
SP  - 960
EP  - 963
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - CHAP
A1  - Nordheim, J.
A1  - Rapp, Michael A.
A1  - Krause-Koehler, Kathleen
A1  - Niemann-Mirmehdi, M.
A1  - Haeusler, Andreas
T1  - Support for dementia affected Couples. Results of the DYADEM- study
T2  - Zeitschrift für Gerontologie und Geriatrie
Y1  - 2014
SN  - 0948-6704
SN  - 1435-1269
VL  - 47
SP  - 136
EP  - 136
PB  - Springer
CY  - Heidelberg
ER  -