TY - JOUR A1 - Starke, Ines A1 - Koch, Andreas A1 - Kammer, Stefan A1 - Holdt, Hans-Jürgen A1 - Möller, Heiko Michael T1 - Electrospray mass spectrometry and molecular modeling study of formation and stability of silver complexes with diazaperylene and bisisoquinoline JF - Journal of mass spectrometry N2 - The complex formation of the following diazaperylene ligands (L) 1,12-diazaperylene 1, 1,1-bisisoquinoline 2, 2,11-disubstituted 1,12-diazaperylenes (alkyl=methyl, ethyl, isopropyl, 3, 5, 7), 3,3-disubstituted 1,1-bisisoquinoline (alkyl=methyl, ethyl, isopropyl, 4, 6, 8 and with R=phenyl, 11 and with pyridine 12), and the 5,8-dimethoxy-substituted diazaperylene 9, 6,6-dimethoxy-substituted bisisoquinoline 10 with AgBF4 was investigated. Collision-induced dissociation measurements were used to evaluate the relative stabilities of the ligands themselves and for the [1:1](+) complexes as well as for the homoleptic and heteroleptic silver [1:2](+) complexes in the gas phase. This method is very useful in rapid screening of the stabilities of new complexes in the gas phase. The influence of the spatial arrangement of the ligands and the type of substituents employed for the complexation were examined. The effect of the preorganization of the diazaperylene on the threshold activation voltages and thus of the relative binding energies of the different complexes are discussed. Density functional theory calculations were used to calculate the optimized structures of the silver complexes and compared with the stabilities of the complexes in the gas phase for the first time. KW - electrospray ionization mass spectrometry and modeling KW - silver(1) complexes KW - stability Y1 - 2018 U6 - https://doi.org/10.1002/jms.4071 SN - 1076-5174 SN - 1096-9888 VL - 53 IS - 5 SP - 408 EP - 418 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Huschbeck, Alina A1 - Knoop, Michael A1 - Gahleitner, Adrian A1 - Koch, Stefan A1 - Schrom, Thomas A1 - Stoffel, Michael A1 - Alfieri, Alex A1 - Dengler, Julius T1 - Recurrent laryngeal nerve palsy after anterior cervical discectomy and fusion BT - prevalence and risk factors JF - Journal of neurological surgery. Part A, Central European neurosurgery N2 - Background and Study Aims Recurrent laryngeal nerve palsy (RLNP) is a potential complication of anterior discectomy and fusion (ACDF). There still is substantial disagreement on the actual prevalence of RLNP after ACDF as well as on risk factors for postoperative RLNP. The aim of this study was to describe the prevalence of postoperative RLNP in a cohort of consecutive cases of ACDF and to examine potential risk factors. Materials and Methods This retrospective study included patients who underwent ACDF between 2005 and 2019 at a single neurosurgical center. As part of clinical routine, RLNP was examined prior to and after surgery by independent otorhinolaryngologists using endoscopic laryngoscopy. As potential risk factors for postoperative RLNP, we examined patient's age, sex, body mass index, multilevel surgery, and the duration of surgery. Results 214 consecutive cases were included. The prevalence of preoperative RLNP was 1.4% (3/214) and the prevalence of postoperative RLNP was 9% (19/211). The number of operated levels was 1 in 73.5% (155/211), 2 in 24.2% (51/211), and 3 or more in 2.4% (5/211) of cases. Of all cases, 4.7% (10/211) were repeat surgeries. There was no difference in the prevalence of RLNP between the primary surgery group (9.0%, 18/183) versus the repeat surgery group (10.0%, 1/10;p = 0.91). Also, there was no difference in any characteristics between subjects with postoperative RLNP compared with those without postoperative RLNP. We found no association between postoperative RLNP and patient's age, sex, body mass index, duration of surgery, or number of levels (odds ratios between 0.24 and 1.05; p values between 0.20 and 0.97). Conclusions In our cohort, the prevalence of postoperative RLNP after ACDF was 9.0%. The fact that none of the examined variables was associated with the occurrence of RLNP supports the view that postoperative RLNP may depend more on direct mechanical manipulation during surgery than on specific patient or surgical characteristics. KW - anterior discectomy and fusion KW - cervical spine surgery KW - recurrent laryngeal nerve palsy KW - vocal cord palsy Y1 - 2020 U6 - https://doi.org/10.1055/s-0040-1710351 SN - 2193-6315 SN - 2193-6323 VL - 81 IS - 06 SP - 508 EP - 512 PB - Thieme CY - New York ER - TY - JOUR A1 - Weber, Michael H. A1 - Abu-Ayyash, Khalil A1 - Abueladas, Abdel-Rahman A1 - Agnon, Amotz A1 - Alasonati-Tašárová, Zuzana A1 - Al-Zubi, Hashim A1 - Babeyko, Andrey A1 - Bartov, Yuval A1 - Bauer, Klaus A1 - Becken, Michael A1 - Bedrosian, Paul A. A1 - Ben-Avraham, Zvi A1 - Bock, Günter A1 - Bohnhoff, Marco A1 - Bribach, Jens A1 - Dulski, Peter A1 - Ebbing, Joerg A1 - El-Kelani, Radwan J. A1 - Foerster, Andrea A1 - Förster, Hans-Jürgen A1 - Frieslander, Uri A1 - Garfunkel, Zvi A1 - Götze, Hans-Jürgen A1 - Haak, Volker A1 - Haberland, Christian A1 - Hassouneh, Mohammed A1 - Helwig, Stefan L. A1 - Hofstetter, Alfons A1 - Hoffmann-Rothe, Arne A1 - Jaeckel, Karl-Heinz A1 - Janssen, Christoph A1 - Jaser, Darweesh A1 - Kesten, Dagmar A1 - Khatib, Mohammed Ghiath A1 - Kind, Rainer A1 - Koch, Olaf A1 - Koulakov, Ivan A1 - Laske, Maria Gabi A1 - Maercklin, Nils T1 - Anatomy of the Dead Sea transform from lithospheric to microscopic scale N2 - Fault zones are the locations where motion of tectonic plates, often associated with earthquakes, is accommodated. Despite a rapid increase in the understanding of faults in the last decades, our knowledge of their geometry, petrophysical properties, and controlling processes remains incomplete. The central questions addressed here in our study of the Dead Sea Transform (DST) in the Middle East are as follows: (1) What are the structure and kinematics of a large fault zone? (2) What controls its structure and kinematics? (3) How does the DST compare to other plate boundary fault zones? The DST has accommodated a total of 105 km of left-lateral transform motion between the African and Arabian plates since early Miocene (similar to 20 Ma). The DST segment between the Dead Sea and the Red Sea, called the Arava/Araba Fault (AF), is studied here using a multidisciplinary and multiscale approach from the mu m to the plate tectonic scale. We observe that under the DST a narrow, subvertical zone cuts through crust and lithosphere. First, from west to east the crustal thickness increases smoothly from 26 to 39 km, and a subhorizontal lower crustal reflector is detected east of the AF. Second, several faults exist in the upper crust in a 40 km wide zone centered on the AF, but none have kilometer-size zones of decreased seismic velocities or zones of high electrical conductivities in the upper crust expected for large damage zones. Third, the AF is the main branch of the DST system, even though it has accommodated only a part (up to 60 km) of the overall 105 km of sinistral plate motion. Fourth, the AF acts as a barrier to fluids to a depth of 4 km, and the lithology changes abruptly across it. Fifth, in the top few hundred meters of the AF a locally transpressional regime is observed in a 100-300 m wide zone of deformed and displaced material, bordered by subparallel faults forming a positive flower structure. Other segments of the AF have a transtensional character with small pull-aparts along them. The damage zones of the individual faults are only 5-20 m wide at this depth range. Sixth, two areas on the AF show mesoscale to microscale faulting and veining in limestone sequences with faulting depths between 2 and 5 km. Seventh, fluids in the AF are carried downward into the fault zone. Only a minor fraction of fluids is derived from ascending hydrothermal fluids. However, we found that on the kilometer scale the AF does not act as an important fluid conduit. Most of these findings are corroborated using thermomechanical modeling where shear deformation in the upper crust is localized in one or two major faults; at larger depth, shear deformation occurs in a 20-40 km wide zone with a mechanically weak decoupling zone extending subvertically through the entire lithosphere. Y1 - 2009 UR - http://www.agu.org/journals/rg/ U6 - https://doi.org/10.1029/2008rg000264 SN - 8755-1209 ER - TY - JOUR A1 - Telkemeyer, Silke A1 - Rossi, Sonja A1 - Koch, Stefan P. A1 - Nierhaus, Till A1 - Steinbrink, Jens A1 - Poeppel, David A1 - Obrig, Hellmuth A1 - Wartenburger, Isabell T1 - Sensitivity of newborn auditory cortex to the temporal structure of sounds N2 - Understanding the rapidly developing building blocks of speech perception in infancy requires a close look at the auditory prerequisites for speech sound processing. Pioneering studies have demonstrated that hemispheric specializations for language processing are already present in early infancy. However, whether these computational asymmetries can be considered a function of linguistic attributes or a consequence of basic temporal signal properties is under debate. Several studies in adults link hemispheric specialization for certain aspects of speech perception to an asymmetry in cortical tuning and reveal that the auditory cortices are differentially sensitive to spectrotemporal features of speech. Applying concurrent electrophysiological (EEG) and hemodynamic (near-infrared spectroscopy) recording to newborn infants listening to temporally structured nonspeech signals, we provide evidence that newborns process nonlinguistic acoustic stimuli that share critical temporal features with language in a differential manner. The newborn brain preferentially processes temporal modulations especially relevant for phoneme perception. In line with multi-time-resolution conceptions, modulations on the time scale of phonemes elicit strong bilateral cortical responses. Our data furthermore suggest that responses to slow acoustic modulations are lateralized to the right hemisphere. That is, the newborn auditory cortex is sensitive to the temporal structure of the auditory input and shows an emerging tendency for functional asymmetry. Hence, our findings support the hypothesis that development of speech perception is linked to basic capacities in auditory processing. From birth, the brain is tuned to critical temporal properties of linguistic signals to facilitate one of the major needs of humans: to communicate. Y1 - 2009 UR - http://www.jneurosci.org/ U6 - https://doi.org/10.1523/Jneurosci.1246-09.2009 SN - 0270-6474 ER - TY - BOOK A1 - Amend-Traut, Anja A1 - Bayerle, Katrin A1 - Duncker, Arne Dirk A1 - Dusil, Stephan A1 - Forster, Wolfgang A1 - Frassek, Ralf A1 - Hermann, Hans-Georg A1 - Koch, Elisabeth A1 - Lettmaier, Saskia A1 - Löhning, Martin A1 - Ludyga, Hannes A1 - Maetschke, Matthias A1 - Mayenburg, David von A1 - Meder, Stephan A1 - Repgen, Tilman A1 - Roth, Andreas A1 - Saar, Stefan Christoph A1 - Schlinker, Steffen A1 - Schmoeckel, Matthias A1 - Schumann, Eva A1 - Thier, Andreas T1 - Familienrecht §§ 1297-1921 T3 - Historisch-kritischer Kommentar zum BGB ; 4 Y1 - 2018 SN - 978-3-16-156399-7 PB - Mohr Siebeck CY - Tübingen ER - TY - JOUR A1 - Aich, Valentin A1 - Liersch, Stefan A1 - Vetter, T. A1 - Huang, S. A1 - Tecklenburg, J. A1 - Hoffmann, P. A1 - Koch, H. A1 - Fournet, S. A1 - Krysanova, Valentina A1 - Mueller, N. A1 - Hattermann, Fred T1 - Comparing impacts of climate change on streamflow in four large African river basins JF - Hydrology and earth system sciences : HESS N2 - This study aims to compare impacts of climate change on streamflow in four large representative African river basins: the Niger, the Upper Blue Nile, the Oubangui and the Limpopo. We set up the eco-hydrological model SWIM (Soil and Water Integrated Model) for all four basins individually. The validation of the models for four basins shows results from adequate to very good, depending on the quality and availability of input and calibration data. For the climate impact assessment, we drive the model with outputs of five bias corrected Earth system models of Coupled Model Intercomparison Project Phase 5 (CMIP5) for the representative concentration pathways (RCPs) 2.6 and 8.5. This climate input is put into the context of climate trends of the whole African continent and compared to a CMIP5 ensemble of 19 models in order to test their representativeness. Subsequently, we compare the trends in mean discharges, seasonality and hydrological extremes in the 21st century. The uncertainty of results for all basins is high. Still, climate change impact is clearly visible for mean discharges but also for extremes in high and low flows. The uncertainty of the projections is the lowest in the Upper Blue Nile, where an increase in streamflow is most likely. In the Niger and the Limpopo basins, the magnitude of trends in both directions is high and has a wide range of uncertainty. In the Oubangui, impacts are the least significant. Our results confirm partly the findings of previous continental impact analyses for Africa. However, contradictory to these studies we find a tendency for increased streamflows in three of the four basins (not for the Oubangui). Guided by these results, we argue for attention to the possible risks of increasing high flows in the face of the dominant water scarcity in Africa. In conclusion, the study shows that impact intercomparisons have added value to the adaptation discussion and may be used for setting up adaptation plans in the context of a holistic approach. Y1 - 2014 U6 - https://doi.org/10.5194/hess-18-1305-2014 SN - 1027-5606 SN - 1607-7938 VL - 18 IS - 4 SP - 1305 EP - 1321 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Koebsch, Franziska A1 - Winkel, Matthias A1 - Liebner, Susanne A1 - Liu, Bo A1 - Westphal, Julia A1 - Schmiedinger, Iris A1 - Spitzy, Alejandro A1 - Gehre, Matthias A1 - Jurasinski, Gerald A1 - Köhler, Stefan A1 - Unger, Viktoria A1 - Koch, Marian A1 - Sachs, Torsten A1 - Böttcher, Michael E. T1 - Sulfate deprivation triggers high methane production in a disturbed and rewetted coastal peatland JF - Biogeosciences N2 - In natural coastal wetlands, high supplies of marine sulfate suppress methanogenesis. Coastal wetlands are, however, often subject to disturbance by diking and drainage for agricultural use and can turn to potent methane sources when rewetted for remediation. This suggests that preceding land use measures can suspend the sulfate-related methane suppressing mechanisms. Here, we unravel the hydrological relocation and biogeochemical S and C transformation processes that induced high methane emissions in a disturbed and rewetted peatland despite former brackish impact. The underlying processes were investigated along a transect of increasing distance to the coastline using a combination of concentration patterns, stable isotope partitioning, and analysis of the microbial community structure. We found that diking and freshwater rewetting caused a distinct freshening and an efficient depletion of the brackish sulfate reservoir by dissimilatory sulfate reduction (DSR). Despite some legacy effects of brackish impact expressed as high amounts of sedimentary S and elevated electrical conductivities, contemporary metabolic processes operated mainly under sulfate-limited conditions. This opened up favorable conditions for the establishment of a prospering methanogenic community in the top 30-40 cm of peat, the structure and physiology of which resemble those of terrestrial organic-rich environments. Locally, high amounts of sulfate persisted in deeper peat layers through the inhibition of DSR, probably by competitive electron acceptors of terrestrial origin, for example Fe(III). However, as sulfate occurred only in peat layers below 30-40 cm, it did not interfere with high methane emissions on an ecosystem scale. Our results indicate that the climate effect of disturbed and remediated coastal wetlands cannot simply be derived by analogy with their natural counterparts. From a greenhouse gas perspective, the re-exposure of diked wetlands to natural coastal dynamics would literally open up the floodgates for a replenishment of the marine sulfate pool and therefore constitute an efficient measure to reduce methane emissions. Y1 - 2019 U6 - https://doi.org/10.5194/bg-16-1937-2019 SN - 1726-4170 SN - 1726-4189 VL - 16 IS - 9 SP - 1937 EP - 1953 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Hörmann, Ulrich A1 - Zeiske, Stefan A1 - Park, Soohyung A1 - Schultz, Thorsten A1 - Kickhoefel, Sebastian A1 - Scherf, Ullrich A1 - Blumstengel, Sylke A1 - Koch, Norbert A1 - Neher, Dieter T1 - Direct observation of state-filling at hybrid tin oxide/organic interfaces JF - Applied physics letters N2 - Electroluminescence (EL) spectra of hybrid charge transfer states at metal oxide/organic type-II heterojunctions exhibit bias-induced spectral shifts. The reasons for this phenomenon have been discussed controversially and arguments for either electric field-induced effects or the filling of trap states at the oxide surface have been put forward. Here, we combine the results of EL and photovoltaic measurements to eliminate the unavoidable effect of the series resistance of inorganic and organic components on the total voltage drop across the hybrid device. For SnOx combined with the conjugated polymer [ladder type poly-(para-phenylene)], we find a one-to-one correspondence between the blue-shift of the EL peak and the increase of the quasi-Fermi level splitting at the hybrid heterojunction, which we unambiguously assign to state filling. Our data are resembled best by a model considering the combination of an exponential density of states with a doped semiconductor. Published under license by AIP Publishing. Y1 - 2019 U6 - https://doi.org/10.1063/1.5082704 SN - 0003-6951 SN - 1077-3118 VL - 114 IS - 18 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Hörmann, Ulrich A1 - Zeiske, Stefan A1 - Piersimoni, Fortunato A1 - Hoffmann, Lukas A1 - Schlesinger, Raphael A1 - Koch, Norbert A1 - Riedl, Thomas A1 - Andrienko, Denis A1 - Neher, Dieter T1 - Stark effect of hybrid charge transfer states at planar ZnO/organic interfaces JF - Physical review : B, Condensed matter and materials physics N2 - We investigate the bias dependence of the hybrid charge transfer state emission at planar heterojunctions between the metal oxide acceptor ZnO and three donor molecules. The electroluminescence peak energy linearly increases with the applied bias, saturating at high fields. Variation of the organic layer thickness and deliberate change of the ZnO conductivity through controlled photodoping allow us to confirm that this bias-induced spectral shift relates to the internal electric field in the organic layer rather than the filling of states at the hybrid interface. We show that existing continuum models overestimate the hole delocalization and propose a simple electrostatic model in which the linear and quadratic Stark effects are explained by the electrostatic interaction of a strongly polarizable molecular cation with its mirror image. Y1 - 2018 U6 - https://doi.org/10.1103/PhysRevB.98.155312 SN - 2469-9950 SN - 2469-9969 VL - 98 IS - 15 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Raoufi, Meysam A1 - Hörmann, Ulrich A1 - Ligorio, Giovanni A1 - Hildebrandt, Jana A1 - Pätzel, Michael A1 - Schultz, Thorsten A1 - Perdigón-Toro, Lorena A1 - Koch, Norbert A1 - List-Kratochvil, Emil A1 - Hecht, Stefan A1 - Neher, Dieter T1 - Simultaneous effect of ultraviolet radiation and surface modification on the work function and hole injection properties of ZnO thin films JF - Physica Status Solidi. A , Applications and materials science N2 - The combined effect of ultraviolet (UV) light soaking and self-assembled monolayer deposition on the work function (WF) of thin ZnO layers and on the efficiency of hole injection into the prototypical conjugated polymer poly(3-hexylthiophen-2,5-diyl) (P3HT) is systematically investigated. It is shown that the WF and injection efficiency depend strongly on the history of UV light exposure. Proper treatment of the ZnO layer enables ohmic hole injection into P3HT, demonstrating ZnO as a potential anode material for organic optoelectronic devices. The results also suggest that valid conclusions on the energy-level alignment at the ZnO/organic interfaces may only be drawn if the illumination history is precisely known and controlled. This is inherently problematic when comparing electronic data from ultraviolet photoelectron spectroscopy (UPS) measurements carried out under different or ill-defined illumination conditions. KW - charge injection across hybrid interfaces KW - energy-level alignments KW - hybrid metal oxides KW - organic interfaces Y1 - 2020 U6 - https://doi.org/10.1002/pssa.201900876 SN - 1862-6300 SN - 1862-6319 VL - 217 IS - 5 SP - 1 EP - 6 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Garbusow, Maria A1 - Schad, Daniel A1 - Sebold, Miriam A1 - Friedel, Eva A1 - Bernhardt, Nadine A1 - Koch, Stefan P. A1 - Steinacher, Bruno A1 - Kathmann, Norbert A1 - Geurts, Dirk E. M. A1 - Sommer, Christian A1 - Mueller, Dirk K. A1 - Nebe, Stephan A1 - Paul, Soeren A1 - Wittchen, Hans-Ulrich A1 - Zimmermann, Ulrich S. A1 - Walter, Henrik A1 - Smolka, Michael N. A1 - Sterzer, Philipp A1 - Rapp, Michael A. A1 - Huys, Quentin J. M. A1 - Schlagenhauf, Florian A1 - Heinz, Andreas T1 - Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence JF - Addiction biology N2 - In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n=31 detoxified patients diagnosed with alcohol dependence and n=24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence. KW - human Pavlovian-to-instrumental transfer KW - nucleus accumbens KW - relapse in alcohol use disorder Y1 - 2016 U6 - https://doi.org/10.1111/adb.12243 SN - 1355-6215 SN - 1369-1600 VL - 21 SP - 719 EP - 731 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Warby, Jonathan A1 - Zu, Fengshuo A1 - Zeiske, Stefan A1 - Gutierrez-Partida, Emilio A1 - Frohloff, Lennart A1 - Kahmann, Simon A1 - Frohna, Kyle A1 - Mosconi, Edoardo A1 - Radicchi, Eros A1 - Lang, Felix A1 - Shah, Sahil A1 - Pena-Camargo, Francisco A1 - Hempel, Hannes A1 - Unold, Thomas A1 - Koch, Norbert A1 - Armin, Ardalan A1 - De Angelis, Filippo A1 - Stranks, Samuel D. A1 - Neher, Dieter A1 - Stolterfoht, Martin T1 - Understanding performance limiting interfacial recombination in pin Perovskite solar cells JF - Advanced energy materials N2 - Perovskite semiconductors are an attractive option to overcome the limitations of established silicon based photovoltaic (PV) technologies due to their exceptional opto-electronic properties and their successful integration into multijunction cells. However, the performance of single- and multijunction cells is largely limited by significant nonradiative recombination at the perovskite/organic electron transport layer junctions. In this work, the cause of interfacial recombination at the perovskite/C-60 interface is revealed via a combination of photoluminescence, photoelectron spectroscopy, and first-principle numerical simulations. It is found that the most significant contribution to the total C-60-induced recombination loss occurs within the first monolayer of C-60, rather than in the bulk of C-60 or at the perovskite surface. The experiments show that the C-60 molecules act as deep trap states when in direct contact with the perovskite. It is further demonstrated that by reducing the surface coverage of C-60, the radiative efficiency of the bare perovskite layer can be retained. The findings of this work pave the way toward overcoming one of the most critical remaining performance losses in perovskite solar cells. KW - C60 KW - defects KW - interface recombination KW - loss mechanisms KW - perovskites KW - solar cells Y1 - 2022 U6 - https://doi.org/10.1002/aenm.202103567 SN - 1614-6832 SN - 1614-6840 VL - 12 IS - 12 PB - Wiley-VCH CY - Weinheim ER -