TY - JOUR A1 - Duydu, Yalcin A1 - Basaran, Nursen A1 - Aydin, Sevtap A1 - Ustundag, Aylin A1 - Yalcin, Can Özgür A1 - Anlar, Hatice Gul A1 - Bacanli, Merve A1 - Aydos, Kaan A1 - Atabekoglu, Cem Somer A1 - Golka, Klaus A1 - Ickstadt, Katja A1 - Schwerdtle, Tanja A1 - Werner, Matthias A1 - Meyer, Sören A1 - Bolt, Hermann M. T1 - Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions JF - Archives of toxicology : official journal of EUROTOX N2 - Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated toxic effects. As validation by another independent study is still required, the present study has investigated possible boron-associated effects on male reproduction in workers (n = 212) under different boron exposure conditions. The mean daily boron exposure (DBE) and blood boron concentration of workers in the extreme exposure group (n = 98) were 47.17 +/- 17.47 (7.95-106.8) mg B/day and 570.6 +/- 160.1 (402.6-1100) ng B/g blood, respectively. Nevertheless, boron-associated adverse effects on semen parameters, as well as on FSH, LH and total testosterone levels were not seen, even within the extreme exposure group. With this study, a total body of evidence has accumulated that allows to conclude that male reproductive effects are not relevant to humans, under any feasible and realistic conditions of exposure to inorganic boron compounds. KW - Boron exposure KW - Boric acid KW - Reproductive toxicity KW - FSH KW - LH KW - Testosterone KW - Semen parameters Y1 - 2018 U6 - https://doi.org/10.1007/s00204-018-2296-7 SN - 0340-5761 SN - 1432-0738 VL - 92 IS - 10 SP - 3051 EP - 3059 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Goetz, Klaus Hermann T1 - The development and current features of the German civil service system Y1 - 2011 SN - 978-1-84844243-6 ER - TY - JOUR A1 - Duydu, Yalcin A1 - Basaran, Nursen A1 - Ustundag, Aylin A1 - Aydin, Sevtap A1 - Yalcin, Can Ozgur A1 - Anlar, Hatice Gul A1 - Bacanli, Merve A1 - Aydos, Kaan A1 - Atabekoglu, Cem Somer A1 - Golka, Klaus A1 - Ickstadt, Katja A1 - Schwerdtle, Tanja A1 - Werner, Matthias A1 - Meyer, Sören A1 - Bolt, Hermann M. T1 - Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey JF - Archives of toxicology : official journal of EUROTOX N2 - Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By contrast, studies on boron-mediated developmental effects in females are scarce. The present study was designed to fill this gap. Hundred and ninety nine females residing in Bandirma and Bigadic participated in this study investigating pregnancy outcomes. The participants constituted a study group covering blood boron from low (< 100 ng B/g blood, n = 143) to high (> 150 ng B/g blood, n = 27) concentrations. The mean blood boron concentration and the mean estimated daily boron exposure of the high exposure group was 274.58 (151.81-975.66) ng B/g blood and 24.67 (10.47-57.86) mg B/day, respectively. In spite of the high level of daily boron exposure, boron-mediated adverse effects on induced abortion, spontaneous abortion (miscarriage), stillbirth, infant death, neonatal death, early neonatal death, preterm birth, congenital anomalies, sex ratio and birth weight of newborns were not observed. KW - Boric acid KW - Boron exposure KW - Biological monitoring KW - Developmental toxicity KW - Pregnancy outcomes Y1 - 2018 U6 - https://doi.org/10.1007/s00204-018-2238-4 SN - 0340-5761 SN - 1432-0738 VL - 92 IS - 8 SP - 2475 EP - 2485 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Basaran, Nursen A1 - Duydu, Yalcin A1 - Ustundag, Aylin A1 - Taner, Gokce A1 - Aydin, Sevtap A1 - Anlar, Hatice Gul A1 - Yalcin, Can Özgür A1 - Bacanli, Merve A1 - Aydos, Kaan A1 - Atabekoglu, Cem Somer A1 - Golka, Klaus A1 - Ickstadt, Katja A1 - Schwerdtle, Tanja A1 - Werner, Matthias A1 - Meyer, Sören A1 - Bolt, Hermann M. T1 - Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis N2 - Industrial production and use of boron compounds have increased during the last decades, especially for the manufacture of borosilicate glass, fiberglass, metal alloys and flame retardants. This study was conducted in two districts of Balikesir; Bandirma and Bigadic, which geographically belong to the Marmara Region of Turkey. Bandirma is the production and exportation zone for the produced boric acid and some borates and Bigadic has the largest B deposits in Turkey. 102 male workers who were occupationally exposed to boron from Bandirma and 110 workers who were occupationally and environmentally exposed to boron from Bigadic participated to our study. In this study the DNA damage in the sperm, blood and buccal cells of 212 males was evaluated by comet and micronucleus assays. No significant increase in the DNA damage in blood, sperm and buccal cells was observed in the residents exposed to boron both occupationally and environmentally (p = 0.861) for Comet test in the sperm samples, p = 0.116 for Comet test in the lymphocyte samples, p = 0.042 for micronucleus (MN) test, p = 0.955 for binucleated cells (BN), p = 1.486 for condensed chromatin (CC), p = 0.455 for karyorrhectic cells (KHC), p = 0.541 for karyolitic cells (KLY), p = 1.057 for pyknotic cells (PHC), p = 0.331 for nuclear bud (NBUD)). No correlations were seen between blood boron levels and tail intensity values of the sperm samples, lymphocyte samples, frequencies of MN, BN, KHC, KYL, PHC and NBUD. The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions. KW - Boric acid KW - Boron exposure KW - DNA damage KW - Comet assay Y1 - 2019 U6 - https://doi.org/10.1016/j.mrgentox.2018.12.013 SN - 1383-5718 SN - 1879-3592 VL - 843 SP - 33 EP - 39 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Duydu, Yalcin A1 - Basaran, Nursen A1 - Yalcin, Can Özgür A1 - Ustundag, Aylin A1 - Aydin, Sevtap A1 - Anlar, Hatice Gul A1 - Bacanli, Merve A1 - Aydos, Kaan A1 - Atabekoglu, Cem Somer A1 - Golka, Klaus A1 - Ickstadt, Katja A1 - Schwerdtle, Tanja A1 - Werner, Matthias A1 - Bolt, Hermann M. T1 - Boron-exposed male workers in Turkey BT - no change in sperm Y:X chromosome ratio and in offspring's sex ratio JF - Archives of toxicology : official journal of EUROTOX N2 - Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest ("extreme") exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 +/- 18.32 mg B/day, 1643.23 +/- 965.44 ng B/g semen and 553.83 +/- 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions. KW - Paternal exposure KW - Boron exposure KW - Y:X chromosome ratio KW - Sex ratio at birth Y1 - 2019 U6 - https://doi.org/10.1007/s00204-019-02391-z SN - 0340-5761 SN - 1432-0738 VL - 93 IS - 3 SP - 743 EP - 751 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Başaran, Nurşen A1 - Duydu, Yalçın A1 - Üstündağ, Aylin A1 - Taner, Gökçe A1 - Aydin Dilsiz, Sevtap A1 - Anlar, Hatice Gül A1 - Yalçin, Can Özgür A1 - Bacanli, Merve A1 - Golka, Klaus A1 - Schwerdtle, Tanja A1 - Bolt, Hermann M. T1 - Environmental boron exposure does not induce DNA damage in lymphocytes and buccal cells of females DNA damage in lymphocytes and buccal cells of boron exposed females JF - Journal of trace elements in medicine and biology N2 - Boron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B exposure in women living in boron-rich and boronpoor areas was examined in this study. For this purpose, the DNA damage in the lymphocytes and buccal cells of females were assessed by Comet and micronucleus (MN) assays respectively. No significant difference was observed in the DNA damage of the lymphocytes of B exposed groups of female volunteers in Comet assay. Even buccal micronucleus (MN) frequency observed in the high exposure group was significantly lower than the low exposure group (p < 0.05). The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions. KW - Boric acid KW - Boron exposure KW - DNA damage Y1 - 2019 U6 - https://doi.org/10.1016/j.jtemb.2019.03.004 SN - 0946-672X VL - 53 SP - 150 EP - 153 PB - Elsevier B.V. CY - München ER - TY - BOOK A1 - Becker, Ulrich A1 - Benedens, Niels Peter A1 - Deppe, Volker A1 - Düwel, Martin A1 - Hermann, Klaus A1 - Kluge, Johannes A1 - Liedtke, Frank A1 - Schmidt, Jürgen A1 - Schmidt, Thorsten Ingo A1 - Baum, Christoph T1 - Kommunalabgabengesetz für das Land Brandenburg BT - abgaberechtliche Vorschriften des Landes Berlin : Kommentar, Text T3 - Gesetze, Verordnungen, Kommentare N2 - Das Kommunalabgabengesetz für das Land Brandenburg (KAG) ist eine für alle Kommunalverwaltungen, Zweckverbände und Anwälte wichtige Rechtsmaterie. Den 20 Paragrafen steht eine Fülle von Fragen nach Auslegung und Anwendung des Gesetzes gegenüber, die von der Rechtsprechung mit zahlreichen Entscheidungen beantwortet werden. Mit dem Werk "Kommunalabgabengesetz für das Land Brandenburg" liegt ein umfassender Kommentar vor, der sich mit der Auslegung des brandenburgischen Kommunalabgabengesetzes (KAG) und der dazu ergangenen Rechtsprechung befasst. Die zahlreichsten Gerichtsentscheidungen beinhaltet die Kommentierung zu § 6 (Benutzungsgebühren) Einerseits darf der Titel für sich in Anspruch nehmen, auch nicht speziell juristisch ausgebildete Nutzer in die Rechtsvorschriften zum KAG Brandenburg einzuführen. Andererseits will es aber auch den mit dem Abgabenrecht befassten Fachleuten in Verwaltungen, Verbänden, Gerichten und Kanzleien eine solide Grundlage für möglichst rechtssichere Entscheidungen bieten. Der engen räumlichen Nähe wegen beinhaltet das Werk die Abgabenrechtlichen Vorschriften des Landes Berlin. KW - Abgaben KW - Steuern KW - Gebühren KW - Beiträge KW - Abgabenbescheide KW - KAG Y1 - 2006 SN - 978-3-8293-0764-2 N1 - Loseblattsammlung PB - Kommunal- und Schul-Verlag CY - Wiesbaden ER - TY - JOUR A1 - Goetz, Klaus Hermann T1 - How does the EU tick? Five propositions on political time Y1 - 2012 SN - 978-0- 415-69633-3 ER - TY - BOOK A1 - Goetz, Klaus Hermann T1 - Zeitpolitik in Europa : Antrittsvorlesung 2007-06-27 N2 - Demokratie bedeutet "Macht auf Zeit", d. h. temporale Machtbegrenzung vermittels regelmäßiger Wahlen. Die Wahlzyklen bilden den bestimmenden Rhythmus der Demokratie. Dieser Grundsatz kommt innerhalb der EU nur in sehr abgeschwächter Form zum Tragen. Vor diesem Hintergrund widmet sich die Vorlesung der Frage, welche Funktionen politische Zeit im politischen System der EU erfüllt; welche besonderen Zeitregeln und -horizonte bestimmend sind; und wie sich die Eigenzeit der EU auf den Rhythmus der Demokratie in den Mitgliedsstaaten auswirkt. Y1 - 2007 UR - http://info.ub.uni-potsdam.de/multimedia/show_projekt.php?projekt_id=3 PB - Univ.-Bibl. CY - Potsdam ER - TY - JOUR A1 - Goetz, Klaus Hermann A1 - Meyer-Sahling, Jan-Hinrik T1 - Political time in the EU : dimensions, perspectives, theories N2 - The manner in which time is institutionalized is critical to how a political system works. Terms, time budgets and time horizons of collective and individual political actors; rights over timing, sequencing and speed in decision- making; and the temporal properties of policy matter to the distribution of power; efficiency and effectiveness of policy-making; and democratic legitimacy. This article makes a case for the systematic study of political time in the European Union (EU) - both as an independent and a dependent variable - and highlights the analytical value-added of a time-centred analysis. The article discusses previous scholarship on the institutionalization of political time and its consequences along the dimensions of polity, politics and policy; and then reviews dominant perspectives on political time, which centre on power, system performance and legitimacy. These perspectives tie in with diverse theoretical traditions in the study of the EU. Taken together, dimensions, perspectives and theories help to guide time-centred analyses of the EU political system. Y1 - 2009 UR - http://www.ingentaconnect.com/content/routledg/rjpp U6 - https://doi.org/10.1080/13501760802589198 SN - 1350-1763 ER - TY - JOUR A1 - Goetz, Klaus Hermann A1 - Meyer-Sahling, Jan-Hinrik T1 - Political time in the EU: dimensions, perspectives, theories Y1 - 2012 SN - 978-0- 415-69633-3 ER - TY - JOUR A1 - Meyer-Sahling, Jan-Hinrik A1 - Goetz, Klaus Hermann T1 - The EU timescape : from notion to research agenda Y1 - 2012 SN - 978-0- 415-69633-3 ER - TY - JOUR A1 - Goetz, Klaus Hermann T1 - A question of time: responsive and responsible democratic politics JF - West European politics N2 - Since 2008, European crisis politics have thrown the importance of time in democracy into sharp relief. The need for rapid action by national authorities, the EU and international organisations conflicts with the time-consuming nature of democratic deliberation; short-term political firefighting has given little consideration to the long-term sustainability and time consistency of policies; and decentralised decisions threaten effective synchronisation within multi-level governance systems. This article suggests that democratic politics requires a balance between the temporal characteristics of responsive and responsible politics. The timeframe for responsive politics is shaped by electoral cycles that encourage speedy action; short-term lags between political choices and their effects; and temporal discretion of decision-makers. The timeframe for responsible politics is characterised by time-consuming procedures; solutions that take time to unfold and are sustainable in the longer term; and the purposive synchronisation amongst actors and across policy domains and levels of policy-making. The finely balanced temporal constitution of democracy has been challenged in two fundamental ways. First, as the ability of decision-makers to work within the time limits of their mandates and to respond to the temporal expectations of the electorate decreases, the temporal ties that ensure the responsiveness of political authority to the electorate weaken. Second, the distinct temporal qualities of majoritarian and non-majoritarian institutions that encourage responsibility are called into question. Consequently, political time in Europe runs the risk of becoming both less responsive and less responsible. Y1 - 2014 U6 - https://doi.org/10.1080/01402382.2014.887880 SN - 0140-2382 SN - 1743-9655 VL - 37 IS - 2 SP - 379 EP - 399 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Duydu, Yalcin A1 - Basaran, Nursen A1 - Aydin, Sevtap A1 - Ustundag, Aylin A1 - Goktas, Hatica Gul A1 - Yalcin, Can Özgür A1 - Bacanli, Merve A1 - Sarigol, Zehra A1 - Aydos, Kaan A1 - Atabekoglu, Cem Somer A1 - Schwerdtle, Tanja A1 - Golka, Klaus A1 - Ickstadt, Katja A1 - Bolt, Hermann M. T1 - Investigation of boron mediated reproductive and developmental effects in highly boron exposed population T2 - Toxicology letters Y1 - 2017 U6 - https://doi.org/10.1016/j.toxlet.2017.07.259 SN - 0378-4274 SN - 1879-3169 VL - 280 SP - S94 EP - S94 PB - Elsevier CY - Clare ER -