TY - JOUR A1 - Klaus, Stefanie A1 - Gzik, Axel T1 - Aminosäurenmuster in Wurzeln von Agrostis stolonifera L Y1 - 1997 ER - TY - JOUR A1 - Klaus, Stefanie A1 - Gzik, Axel T1 - Veränderungen im Zuckergehalt der Wurzeln von Feuchtwiesengräsern unter osmotischem Stress Y1 - 1999 ER - TY - BOOK A1 - Bergmann, Stephan A1 - Ehrhart, Wolfgang A1 - Hamm, Brigitte A1 - Hasse, Jana A1 - Hedrich, Klaus-Jürgen A1 - Obser, Andreas A1 - Schurer, Stefanie A1 - Tönnies, Sibylle ED - Klein, Eckart ED - Volger, Helmut T1 - Bilanz ein Jahr nach dem Millennium BT - Reformkonzepte und deren Implementierung T3 - Potsdamer UNO-Konferenzen N2 - Die ersten beiden Konferenzen des Forschungskreises Vereinte Nationen im Dezember 1999 und im Juni 2000 in der Universität Potsdam standen im Zeichen des interdisziplinären Dialogs in der UN-Forschung zwischen Völkerrechts- und Politikwissenschaft und dienten zugleich der Standortbestimmung der deutschen UN-Forschung im internationalen Kontext. Die dritte Konferenz des Forschungskreises, die am 29. und 30. Juni 2001 wiederum in den Räumen der Juristischen Fakultät der Universität Potsdam stattfand, widmete sich der Bilanz der Arbeit der Vereinten Nationen ein Jahr nach dem Milleniumsgipfel 2000 in New York in ihren Hauptaufgabengebieten sowie der deutschen UN-Politik in diesem Kontext. Die in dieser Broschüre veröffentlichten Referate der dritten Konferenz spiegeln zusammen mit den Diskussionen, die zusammenfassend dargestellt werden, die weitreichenden strukturellen Probleme, denen sich die Vereinten Nationen durch die Prozesse der Globalisierung in der Friedenssicherung, beim Schutz der Menschenrechte und in der multilateralen Entwicklungszusammenarbeit ausgesetzt sehen. Sie stellen eine erste Evaluation der Reformmaßnahmen dar, die seit dem Milleniumsgipfel beschlossen wurden. Zugleich verdeutlichen sie die enge Wechselbeziehung zwischen der Arbeit der Weltorganisation und der nationalen Außenpolitik ihrer Mitgliedsländer, wie sie sich am Beispiel der Bundesrepublik Deutschland zeigt. T3 - Potsdamer UNO-Konferenzen - 2 KW - United Nations KW - Politik KW - Kongress KW - Geschichte : 2000-2001 KW - international relations KW - non-governmental organizations KW - human rights Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-72403 IS - 2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Fernando, Raquel A1 - Drescher, Cathleen A1 - Deubel, Stefanie A1 - Jung, Tobias A1 - Ost, Mario A1 - Klaus, Susanne A1 - Grune, Tilman A1 - Castro, Jose Pedro T1 - Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage JF - Experimental gerontology N2 - The skeletal muscle is a crucial tissue for maintaining whole body homeostasis. Aging seems to have a disruptive effect on skeletal muscle homeostasis including proteostasis. However, how aging specifically impacts slow and fast twitch fiber types remains elusive. Muscle proteostasis is largely maintained by the proteasomal system. Here we characterized the proteasomal system in two different fiber types, using a non-sarcopenic aging model. By analyzing the proteasomal activity and amount, as well as the polyubiquitinated proteins and the level of protein oxidation in Musculus soleus (Sol) and Musculus extensor digitorum longus (EDL), we found that the slow twitch Sol muscle shows an overall higher respiratory and proteasomal activity in young and old animals. However, especially during aging the fast twitch EDL muscle reduces protein oxidation by an increase of antioxidant capacity. Thus, under adaptive non-sarcopenic conditions, the two fibers types seem to have different strategies to avoid age-related changes. KW - Proteasomal system KW - Skeletal muscle KW - Fast and slow fibers KW - Polyubiquitination KW - Oxidized proteins KW - Antioxidants KW - Aging KW - Mitochondrial respiration Y1 - 2018 U6 - https://doi.org/10.1016/j.exger.2018.10.018 SN - 0531-5565 SN - 1873-6815 VL - 117 SP - 45 EP - 52 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Klaus, Benita A1 - Müller, Patrick A1 - van Wickeren, Nora A1 - Dordevic, Milos A1 - Schmicker, Marlen A1 - Zdunczyk, Yael A1 - Brigadski, Tanja A1 - Lessmann, Volkmar A1 - Vielhaber, Stefan A1 - Schreiber, Stefanie A1 - Müller, Notger Germar T1 - Structural and functional brain alterations in patients with myasthenia gravis JF - Brain communications N2 - Myasthenia gravis is an autoimmune disease affecting neuromuscular transmission and causing skeletal muscle weakness. Additionally, systemic inflammation, cognitive deficits and autonomic dysfunction have been described. However, little is known about myasthenia gravis-related reorganization of the brain. In this study, we thus investigated the structural and functional brain changes in myasthenia gravis patients. Eleven myasthenia gravis patients (age: 70.64 +/- 9.27; 11 males) were compared to age-, sex- and education-matched healthy controls (age: 70.18 +/- 8.98; 11 males). Most of the patients (n = 10, 0.91%) received cholinesterase inhibitors. Structural brain changes were determined by applying voxel-based morphometry using high-resolution T-1-weighted sequences. Functional brain changes were assessed with a neuropsychological test battery (including attention, memory and executive functions), a spatial orientation task and brain-derived neurotrophic factor blood levels. Myasthenia gravis patients showed significant grey matter volume reductions in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus. Furthermore, myasthenia gravis patients showed significantly lower performance in executive functions, working memory (Spatial Span, P = 0.034, d = 1.466), verbal episodic memory (P = 0.003, d = 1.468) and somatosensory-related spatial orientation (Triangle Completion Test, P = 0.003, d = 1.200). Additionally, serum brain-derived neurotrophic factor levels were significantly higher in myasthenia gravis patients (P = 0.001, d = 2.040). Our results indicate that myasthenia gravis is associated with structural and functional brain alterations. Especially the grey matter volume changes in the cingulate gyrus and the inferior parietal lobe could be associated with cognitive deficits in memory and executive functions. Furthermore, deficits in somatosensory-related spatial orientation could be associated with the lower volumes in the inferior parietal lobe. Future research is needed to replicate these findings independently in a larger sample and to investigate the underlying mechanisms in more detail. Klaus et al. compared myasthenia gravis patients to matched healthy control subjects and identified functional alterations in memory functions as well as structural alterations in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus. KW - myasthenia gravis KW - neuroplasticity KW - VBM KW - neuropsychological testing KW - BDNF Y1 - 2022 U6 - https://doi.org/10.1093/braincomms/fcac018 SN - 2632-1297 VL - 4 IS - 1 PB - Oxford Univ. Press CY - Oxford ER -