TY  - JOUR
A1  - John, Cathleen
A1  - Grune, Jana
A1  - Ott, Christiane
A1  - Nowotny, Kerstin
A1  - Deubel, Stefanie
A1  - Kühne, Arne
A1  - Schubert, Carola
A1  - Kintscher, Ulrich
A1  - Regitz-Zagrosek, Vera
A1  - Grune, Tilman
T1  - Sex Differences in Cardiac Mitochondria in the New Zealand Obese Mouse
JF  - Frontiers in Endocrinology
N2  - Background: Obesity is a risk factor for diseases including type 2 diabetes mellitus (T2DM) and cardiovascular disorders. Diabetes itself contributes to cardiac damage. Thus, studying cardiovascular events and establishing therapeutic intervention in the period of type T2DM onset and manifestation are of highest importance. Mitochondrial dysfunction is one of the pathophysiological mechanisms leading to impaired cardiac function. Methods: An adequate animal model for studying pathophysiology of T2DM is the New Zealand Obese (NZO) mouse. These mice were maintained on a high-fat diet (HFD) without carbohydrates for 13 weeks followed by 4 week HFD with carbohydrates. NZO mice developed severe obesity and only male mice developed manifest T2DM. We determined cardiac phenotypes and mitochondrial function as well as cardiomyocyte signaling in this model. Results: The development of an obese phenotype and T2DM in male mice was accompanied by an impaired systolic function as judged by echocardiography and MyH6/7 expression. Moreover, the mitochondrial function only in male NZO hearts was significantly reduced and ERK1/2 and AMPK protein levels were altered. Conclusions: This is the first report demonstrating that the cardiac phenotype in male diabetic NZO mice is associated with impaired cardiac energy function and signaling events.
KW  - NZO
KW  - heart
KW  - obesity
KW  - mitochondrial function
KW  - echocardiography
KW  - systolic function
Y1  - 2018
U6  - https://doi.org/10.3389/fendo.2018.00732
SN  - 1664-2392
VL  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Grune, Kerstin
A1  - Metz, Anna-Marie
A1  - Hagendorf, Herbert
T1  - ERP Variations related to time course manipulations during presentation of consonant sequences
Y1  - 1995
SN  - 3-925978-45-3
ER  - 
TY  - JOUR
A1  - Grune, Kerstin
A1  - Metz, Anna-Marie
A1  - Hagendorf, Herbert
T1  - Arbeitsgedächtnisfunktionen und ereigniskorrelierte Hirnpotentiale
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Grune, Kerstin
A1  - Ullsperger, Peter
T1  - In Search of the Internal Model : P300 and Concept Learning
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Grune, Kerstin
A1  - Metz, Anna-Marie
A1  - Hagendorf, Herbert
T1  - Information processing in working memory and P300
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Ribback, Sven
A1  - Grune, Kerstin
A1  - Metz, Anna-Marie
A1  - Hagendorf, Herbert
T1  - Variationen der P300- Amplitude bei seqeuntiell zunehmender Belastung des Arbeitsgedächtnisses
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Grune, Kerstin
A1  - Metz, Anna-Marie
T1  - Information processing in working memory and event-related brain potentials
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Kusak, Guido
A1  - Grune, Kerstin
A1  - Hagendorf, Herbert
A1  - Metz, Anna-Marie
T1  - Wirkungen der Vorbelastung des Arbeitsgedächtnisses auf Komponenten evozierter Potentiale beim sequentiellen Einprägen verbalen Materials
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Metz, Anna-Marie
A1  - Hagendorf, Herbert
A1  - Grune, Kerstin
T1  - Arbeitsgedächtnisfunktionen und ereigniskorrelierte Hirnpotentiale
Y1  - 1994
ER  - 
TY  - JOUR
A1  - Grune, Kerstin
A1  - Metz, Anna-Marie
A1  - Hagendorf, Herbert
T1  - ERP Variations related to time course manipulations during presentation of consonant sequences
Y1  - 1996
ER  -