TY  - JOUR
A1  - Schönemann, Eric
A1  - Koc, Julian
A1  - Karthäuser, Jana
A1  - Özcan, Onur
A1  - Schanzenbach, Dirk
A1  - Schardt, Lisa
A1  - Rosenhahn, Axel
A1  - Laschewsky, André
T1  - Sulfobetaine methacrylate polymers of unconventional polyzwitterion architecture and their antifouling properties
JF  - Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences
N2  - Combining high hydrophilicity with charge neutrality, polyzwitterions are intensely explored for their high biocompatibility and low-fouling properties. Recent reports indicated that in addition to charge neutrality, the zwitterion's segmental dipole orientation is an important factor for interacting with the environment. Accordingly, a series of polysulfobetaines with a novel architecture was designed, in which the cationic and anionic groups of the zwitterionic moiety are placed at equal distances from the backbone. They were investigated by in vitro biofouling assays, covering proteins of different charges and model marine organisms. All polyzwitterion coatings reduced the fouling effectively compared to model polymer surfaces of poly(butyl methacrylate), with a nearly equally good performance as the reference polybetaine poly(3-(N-(2-(methacryloyloxy)ethyl)-N,N-dimethylammonio)propanesulfonate). The specific fouling resistance depended on the detailed chemical structure of the polyzwitterions. Still, while clearly affecting the performance, the precise dipole orientation of the sulfobetaine group in the polyzwitterions seems overall to be only of secondary importance for their antifouling behavior.
Y1  - 2021
U6  - https://doi.org/10.1021/acs.biomac.0c01705
SN  - 1525-7797
SN  - 1526-4602
VL  - 22
IS  - 4
SP  - 1494
EP  - 1508
PB  - American Chemical Society
CY  - Washington
ER  -