TY  - JOUR
A1  - Engeli, Stefan
A1  - Lehmann, Anne-Christin
A1  - Kaminski, Jana
A1  - Haas, Verena
A1  - Janke, Urgen
A1  - Janke, Jürgen
A1  - Zoerner, Alexander A.
A1  - Luft, Friedrich C.
A1  - Tsikas, Dimitrios
A1  - Jordan, Jens
T1  - Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects
JF  - Obesity
N2  - Objective: Endocannabinoid system (ECS) activation promotes obesity-associated metabolic disease. Increased dietary fat intake increases blood endocannabinoids and alters adipose and skeletal muscle ECS gene expression in human.
 Methods: Two weeks isocaloric low- (LFD) and high-fat diets (HFD) in obese (n = 12) and normal- weight (n = 17) subjects in a randomized cross-over study were compared. Blood endocannabinoids were measured in the fasting condition and after food intake using mass spectrometry. Adipose and skeletal muscle gene expression was determined using real-time RT-PCR.
 Results: Baseline fasting plasma endocannabinoids were similar with both diets. Anandamide decreased similarly with high- or low-fat test meals in both groups. Baseline arachidonoylglycerol plasma concentrations were similar between groups and diets, and unresponsive to eating. In subcutaneous adipose tissue, DAGL-alpha mRNA was upregulated and fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mRNAs were down-regulated in obese subjects, but the diets had no influence. In contrast, the HFD produced pronounced reductions in skeletal muscle CB1-R and MAGL mRNA expression, whereas obesity did not affect muscular gene expression.
 Conclusions: Weight-neutral changes in dietary fat intake cannot explain excessive endocannabinoid availability in human obesity. Obesity and dietary fat intake affect ECS gene expression in a tissue-specific manner.
Y1  - 2014
U6  - https://doi.org/10.1002/oby.20728
SN  - 1930-7381
SN  - 1930-739X
VL  - 22
IS  - 5
SP  - E70
EP  - E76
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Salzwedel, Annett
A1  - Reibis, Rona Katharina
A1  - Wegscheider, Karl
A1  - Eichler, Sarah
A1  - Buhlert, Hermann
A1  - Kaminski, Stefan
A1  - Völler, Heinz
T1  - Cardiopulmonary exercise testing is predictive of return to work in cardiac patients after multicomponent rehabilitation
JF  - Clinical research in cardiology : official journal of the German Cardiac Society.
N2  - Return to work (RTW) is a pivotal goal of cardiac rehabilitation (CR) in patients after acute cardiac event. We aimed to evaluate cardiopulmonary exercise testing (CPX) parameters as predictors for RTW at discharge after CR. We analyzed data from a registry of 489 working-age patients (51.5 +/- A 6.9 years, 87.9 % men) who had undergone inpatient CR predominantly after percutaneous coronary intervention (PCI 62.6 %), coronary artery bypass graft (CABG 17.2 %), or heart valve replacement (9.0 %). Sociodemographic and clinical parameters, noninvasive cardiac diagnostic (2D echo, exercise ECG, 6MWT) and psychodiagnostic screening data, as well as CPX findings, were merged with RTW data from the German statutory pension insurance program and analyzed for prognostic ability. During a mean follow-up of 26.5 +/- A 11.9 months, 373 (76.3 %) patients returned to work, 116 (23.7 %) did not, and 60 (12.3 %) retired. After adjustment for covariates, elective CABG (HR 0.68, 95 % CI 0.47-0.98; p = 0.036) and work intensity (per level HR 0.83, 95 % CI 0.73-0.93; p = 0.002) were negatively associated with the probability of RTW. Exercise capacity in CPX (in Watts) and the VE/VCO2-slope had independent prognostic significance for RTW. A higher work load increased (HR 1.17, 95 % CI 1.02-1.35; p = 0.028) the probability of RTW, while a higher VE/VCO2 slope decreased (HR 0.85, 95 % CI 0.76-0.96; p = 0.009) it. CPX also had prognostic value for retirement: the likelihood of retirement decreased with increasing exercise capacity (HR 0.50, 95 % CI 0.30-0.82; p = 0.006).
KW  - Cardiac rehabilitation
KW  - Prognosis
KW  - Exercise capacity
KW  - Coronary disease
KW  - Social medicine
Y1  - 2016
U6  - https://doi.org/10.1007/s00392-015-0917-1
SN  - 1861-0684
SN  - 1861-0692
VL  - 105
SP  - 257
EP  - 267
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - CHAP
A1  - Völler, Heinz
A1  - Salzwedel, Annett
A1  - Reibis, Rona Katharina
A1  - Eichler, Sarah
A1  - Buhlert, Hermann
A1  - Kaminski, Stefan
A1  - Wegscheider, Karl
T1  - Cardiopulmonary exercise testing is predictive of return to work in cardiac patients after multicomponent rehabilitation
T2  - European heart journal
Y1  - 2015
SN  - 0195-668X
SN  - 1522-9645
VL  - 36
SP  - 635
EP  - 636
PB  - Oxford Univ. Press
CY  - Oxford
ER  -