TY - JOUR A1 - Kühn, Elisabeth A1 - Becker, Marc A1 - Harpke, Alexander A1 - Kühn, Ingolf A1 - Kuhlicke, Christian A1 - Schmitt, Thomas A1 - Settele, Josef A1 - Musche, Martin T1 - The benefits of counting butterflies: recommendations for a successful citizen science project JF - Ecology and Society N2 - Citizen science (CS) projects, being popular across many fields of science, have recently also become a popular tool to collect biodiversity data. Although the benefits of such projects for science and policy making are well understood, relatively little is known about the benefits participants get from these projects as well as their personal backgrounds and motivations. Furthermore, very little is known about their expectations. We here examine these aspects, with the citizen science project "German Butterfly Monitoring" as an example. A questionnaire was sent to all participants of the project and the responses to the questionnaire indicated the following: center dot Most transect walkers do not have a professional background in this field, though they do have a high educational level, and are close to retirement, with a high number of females; center dot An important motivation to join the project is to preserve the natural environment and to contribute to scientific knowledge; center dot Participants benefit by enhancing their knowledge about butterflies and especially their ability to identify different species (taxonomic knowledge); center dot Participants do not have specific expectations regarding the project beyond proper management and coordination, but have an intrinsic sense of working for a greater good. The willingness to join a project is higher if the project contributes to the solution of a problem discussed in the media (here, insect decline). Based on our findings from the analysis of the questionnaire we can derive a set of recommendations for establishing a successful CS project. These include the importance of good communication, e.g., by explaining what the (scientific) purpose of the project is and what problems are to be solved with the help of the data collected in the project. The motivation to join a CS project is mostly intrinsic and CS is a good tool to engage people during difficult times such as the COVID-19 pandemic, giving participants the feeling of doing something useful. KW - COVID-19 pandemic KW - gender gap KW - insect decline KW - intrinsic motivation KW - monitoring Y1 - 2022 U6 - https://doi.org/10.5751/ES-12861-270238 SN - 1708-3087 VL - 27 IS - 2 PB - Resilience Alliance CY - Wolfville ER - TY - JOUR A1 - Beye, Martin A1 - Öberg, Henrik A1 - Xin, Hongliang A1 - Dakovski, Georgi L. A1 - Föhlisch, Alexander A1 - Gladh, Jorgen A1 - Hantschmann, Markus A1 - Hieke, Florian A1 - Kaya, Sarp A1 - Kühn, Danilo A1 - LaRue, Jerry A1 - Mercurio, Giuseppe A1 - Minitti, Michael P. A1 - Mitra, Ankush A1 - Moeller, Stefan P. A1 - Ng, May Ling A1 - Nilsson, Anders A1 - Nordlund, Dennis A1 - Norskov, Jens A1 - Öström, Henrik A1 - Ogasawara, Hirohito A1 - Persson, Mats A1 - Schlotter, William F. A1 - Sellberg, Jonas A. A1 - Wolf, Martin A1 - Abild-Pedersen, Frank A1 - Pettersson, Lars G. M. A1 - Wurth, Wilfried T1 - Chemical Bond Activation Observed with an X-ray Laser JF - The journal of physical chemistry letters N2 - The concept of bonding and antibonding orbitals is fundamental in chemistry. The population of those orbitals and the energetic difference between the two reflect the strength of the bonding interaction. Weakening the bond is expected to reduce this energetic splitting, but the transient character of bond-activation has so far prohibited direct experimental access. Here we apply time-resolved soft X-ray spectroscopy at a free electron laser to directly observe the decreased bonding antibonding splitting following bond-activation using an ultrashort optical laser pulse. Y1 - 2016 U6 - https://doi.org/10.1021/acs.jpclett.6b01543 SN - 1948-7185 VL - 7 SP - 3647 EP - 3651 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Miedema, Piter S. A1 - Thielemann-Kühn, Nele A1 - Calafell, Irati Alonso A1 - Schüßler-Langeheine, Christian A1 - Beye, Martin T1 - Strain analysis from M-edge resonant inelastic X-ray scattering of nickel oxide films JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - Electronic structure modifications due to strain are an effective method for tailoring nano-scale functional materials. Demonstrated on nickel oxide (NiO) thin films, Resonant Inelastic X-ray Scattering (RIXS) at the transition-metal M-2,M-3-edge is shown to be a powerful tool for measuring the electronic structure modification due to strain in the near-surface region. Analyses from the M-2,M-3-edge RIXS in comparison with dedicated crystal field multiplet calculations show distortions in 40 nm NiO grown on a magnesium oxide (MgO) substrate (NiO/MgO) similar to those caused by surface relaxation of bulk NiO. The films of 20 and 10 nm NiO/MgO show slightly larger differences from bulk NiO. Quantitatively, the NiO/MgO samples all are distorted from perfect octahedral (O-h) symmetry with a tetragonal parameter Ds of about -0.1 eV, very close to the Ds distortion from octahedral (O-h) symmetry parameter of -0.11 eV obtained for the surface-near region from a bulk NiO crystal. Comparing the spectra of a 20 nm film of NiO grown on a 20 nm magnetite (Fe3O4) film on a MgO substrate (NiO/Fe3O4/MgO) with the calculated multiplet analyses, the distortion parameter Ds appears to be closer to zero, showing that the surface-near region of this templated film is less distorted from O-h symmetry than the surface-near region in bulk NiO. Finally, the potential of M-2,M-3-edge RIXS for other investigations of strain on electronic structure is discussed. Y1 - 2019 U6 - https://doi.org/10.1039/c9cp03593a SN - 1463-9076 SN - 1463-9084 VL - 21 IS - 38 SP - 21596 EP - 21602 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Kleger, Heinz A1 - Kühn, Martin A1 - Stab, Uwe T1 - Bürgerschaft - Bürgerkommune - Bürgerhaushalt Y1 - 2012 SN - 978-3-593-39771-9 ER - TY - JOUR A1 - Kissling, W. D. A1 - Dormann, Carsten F. A1 - Groeneveld, Juergen A1 - Hickler, Thomas A1 - Kühn, Ingolf A1 - McInerny, Greg J. A1 - Montoya, Jose M. A1 - Römermann, Christine A1 - Schiffers, Katja A1 - Schurr, Frank Martin A1 - Singer, Alexander A1 - Svenning, Jens-Christian A1 - Zimmermann, Niklaus E. A1 - O'Hara, Robert B. T1 - Towards novel approaches to modelling biotic interactions in multispecies assemblages at large spatial extents JF - Journal of biogeography N2 - Aim Biotic interactions within guilds or across trophic levels have widely been ignored in species distribution models (SDMs). This synthesis outlines the development of species interaction distribution models (SIDMs), which aim to incorporate multispecies interactions at large spatial extents using interaction matrices. Location Local to global. Methods We review recent approaches for extending classical SDMs to incorporate biotic interactions, and identify some methodological and conceptual limitations. To illustrate possible directions for conceptual advancement we explore three principal ways of modelling multispecies interactions using interaction matrices: simple qualitative linkages between species, quantitative interaction coefficients reflecting interaction strengths, and interactions mediated by interaction currencies. We explain methodological advancements for static interaction data and multispecies time series, and outline methods to reduce complexity when modelling multispecies interactions. Results Classical SDMs ignore biotic interactions and recent SDM extensions only include the unidirectional influence of one or a few species. However, novel methods using error matrices in multivariate regression models allow interactions between multiple species to be modelled explicitly with spatial co-occurrence data. If time series are available, multivariate versions of population dynamic models can be applied that account for the effects and relative importance of species interactions and environmental drivers. These methods need to be extended by incorporating the non-stationarity in interaction coefficients across space and time, and are challenged by the limited empirical knowledge on spatio-temporal variation in the existence and strength of species interactions. Model complexity may be reduced by: (1) using prior ecological knowledge to set a subset of interaction coefficients to zero, (2) modelling guilds and functional groups rather than individual species, and (3) modelling interaction currencies and species effect and response traits. Main conclusions There is great potential for developing novel approaches that incorporate multispecies interactions into the projection of species distributions and community structure at large spatial extents. Progress can be made by: (1) developing statistical models with interaction matrices for multispecies co-occurrence datasets across large-scale environmental gradients, (2) testing the potential and limitations of methods for complexity reduction, and (3) sampling and monitoring comprehensive spatio-temporal data on biotic interactions in multispecies communities. KW - Community ecology KW - ecological networks KW - global change KW - guild assembly KW - multidimensional complexity KW - niche theory KW - prediction KW - species distribution model KW - species interactions KW - trait-based community modules Y1 - 2012 U6 - https://doi.org/10.1111/j.1365-2699.2011.02663.x SN - 0305-0270 VL - 39 IS - 12 SP - 2163 EP - 2178 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Kühn, Tilman A1 - Floegel, Anna A1 - Sookthai, Disorn A1 - Johnson, Theron A1 - Rolle-Kampczyk, Ulrike A1 - Otto, Wolfgang A1 - von Bergen, Martin A1 - Boeing, Heiner A1 - Kaaks, Rudolf T1 - Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study T2 - BMC medicine N2 - Background: First metabolomics studies have indicated that metabolic fingerprints from accessible tissues might be useful to better understand the etiological links between metabolism and cancer. However, there is still a lack of prospective metabolomics studies on pre-diagnostic metabolic alterations and cancer risk. Methods: Associations between pre-diagnostic levels of 120 circulating metabolites (acylcarnitines, amino acids, biogenic amines, phosphatidylcholines, sphingolipids, and hexoses) and the risks of breast, prostate, and colorectal cancer were evaluated by Cox regression analyses using data of a prospective case-cohort study including 835 incident cancer cases. Results: The median follow-up duration was 8.3 years among non-cases and 6.5 years among incident cases of cancer. Higher levels of lysophosphatidylcholines (lysoPCs), and especially lysoPC a C18:0, were consistently related to lower risks of breast, prostate, and colorectal cancer, independent of background factors. In contrast, higher levels of phosphatidylcholine PC ae C30:0 were associated with increased cancer risk. There was no heterogeneity in the observed associations by lag time between blood draw and cancer diagnosis. Conclusion: Changes in blood lipid composition precede the diagnosis of common malignancies by several years. Considering the consistency of the present results across three cancer types the observed alterations point to a global metabolic shift in phosphatidylcholine metabolism that may drive tumorigenesis. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 437 KW - metabolomics KW - epidemiology KW - breast cancer KW - prostate cancer KW - colorectal cancer Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-407258 ER - TY - JOUR A1 - Dallapiazza, Michael A1 - Denz, Rebekka A1 - Feinberg, Anat A1 - Ginsberg, Yona A1 - Grözinger, Elvira A1 - Grözinger, Karl E. A1 - Hartwieg, Gisela A1 - Hiscott, William A1 - Jäckel, Eberhard A1 - Jurewicz, Grażyna A1 - Jütte, Robert A1 - Knufinke, Ulrich A1 - Kosman, Admiʾel A1 - Kuhn, Rick A1 - Messner, Philipp A1 - Mualam, Nir A1 - Pasdzierny, Matthias A1 - Riemer, Nathanael A1 - Shapira, Anita A1 - Szulc, Michał A1 - Ulmer, Martin A1 - Wittkopf, Sarah ED - Denz, Rebekka ED - Dubrau, Alexander ED - Riemer, Nathanael T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. = 100jähriges Jubiläum Tel Avivs T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. = 100th anniversary of Tel Aviv N2 - Aus dem Editorial: "Seit Anfang April diesen Jahres feiert Tel Aviv sein 100jähriges Jubiläum. Bei über 400 verschiedenartigsten Veranstaltungen in dieser israelischen Stadt und in unzähligen Orten außerhalb Israels wird 2009 über deren Geschichte resümiert, reflektiert sowie (kritisch) diskutiert. Dabei wird nicht nur die Geschichte der Stadt thematisiert, sondern gerade auch die Gegenwart und insbesondere deren Zukunft. Aus diesem Anlass weist die diesjährige Ausgabe von PaRDeS den Themenschwerpunkt 100 Jahre Tel Aviv /100th anniversary of Tel Aviv auf. Israelische, (zeitweise) in Tel Aviv oder in anderen Ländern tätige Wissenschaftlerinnen und Wissenschaftler nähern sich aus mitunter sehr unterschiedlichen Perspektiven und Wissensbereichen der Geschichte und Gegenwart dieser größten israelischen Stadt. Anita Shapira eröffnet mit Tel Aviv, a White City on the Sands den insgesamt sieben Artikel umfassenden Themenschwerpunkt. In ihrem Beitrag umreißt sie die Entstehungsgeschichte der israelischen Großstadt bis zur Gründung des Staates Israel 1948. Shapira geht dabei insbesondere auf zionistische Ideen bei der Stadtgründung und deren (stellenweise nicht) erfolgte Realisierung ein. In den 1920er und 30er Jahren wird das modernisierte Hebräisch zur Triebfeder bei der Herausbildung einer neuen säkular-jüdischen Kultur in Palästina. Innerhalb dieses Prozesses nimmt gerade die jungen Metropole Tel Aviv eine bedeutende Rolle ein. Philipp Messner beschreibt in seinem Beitrag Tel Aviv und die Revolution des hebräischen Schriftbilds diese Umwälzungen auf der graphisch-ästhetischen Ebene des hebräischen Schriftbildes. In ihrem Artikel Von der Einwanderung der Jekim zu ihrer politischen Partizipation bei den Wahlen zum Tel Aviver Stadtrat im Jahr 1936 zeigt Sarah Wittkopf anhand des Publikationsorgans Mitteilungsblatt der Irgun Olej Merkas Europa welchen Widerständen die Einwanderer aus den deutschsprachigen Ländern bei der Mitgestaltung der Politik in Palästina ausgesetzt waren. Im Zentrum der Auseinandersetzungen in Tel Aviv steht der Spitzenkandidat der Einwandererorganisation Felix Rosenblüth. Im vierten Artikel Building a Modern Jewish City: Projects of the Architect Wilhelm Zeev Haller in Tel Aviv stellt Ulrich Knufinke Kontinuitätslinien und -brüche im architektonischen Schaffen Wilhelm Zeev Hallers zwischen Europa und Tel Aviv dar." [die Herausgeber] PaRDeS, die Zeitschrift der Vereinigung für Jüdische Studien e.V., möchte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Berührungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung. N2 - The journal aims at documenting the fruitful and multifarious culture of Judaism as well as its relations to its environment within diverse areas of research. In addition, the journal is meant to promote Jewish Studies within academic discourse and discuss its historic and social responsibility. T3 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 15 Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-34600 SN - 978-3-86956-012-0 SN - 1862-7684 SN - 1614-6492 IS - 15 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Sorgenfrei, Nomi A1 - Giangrisostomi, Erika A1 - Jay, Raphael Martin A1 - Kühn, Danilo A1 - Neppl, Stefan A1 - Ovsyannikov, Ruslan A1 - Sezen, Hikmet A1 - Svensson, Svante A1 - Föhlisch, Alexander T1 - Photodriven transient picosecond top-layer semiconductor to metal phase-transition in p-doped molybdenum disulfide JF - Advanced materials N2 - Visible light is shown to create a transient metallic S-Mo-S surface layer on bulk semiconducting p-doped indirect-bandgap 2H-MoS2. Optically created electron-hole pairs separate in the surface band bending region of the p-doped semiconducting crystal causing a transient accumulation of electrons in the surface region. This triggers a reversible 2H-semiconductor to 1T-metal phase-transition of the surface layer. Electron-phonon coupling of the indirect-bandgap p-doped 2H-MoS2 enables this efficient pathway even at a low density of excited electrons with a distinct optical excitation threshold and saturation behavior. This mechanism needs to be taken into consideration when describing the surface properties of illuminated p-doped 2H-MoS2. In particular, light-induced increased charge mobility and surface activation can cause and enhance the photocatalytic and photoassisted electrochemical hydrogen evolution reaction of water on 2H-MoS2. Generally, it opens up for a way to control not only the surface of p-doped 2H-MoS2 but also related dichalcogenides and layered systems. The findings are based on the sensitivity of time-resolved electron spectroscopy for chemical analysis with photon-energy-tuneable synchrotron radiation. KW - catalysis KW - dichalcogenides KW - hydrogen evolution reaction KW - phase transitions KW - photoelectron spectroscopy Y1 - 2021 U6 - https://doi.org/10.1002/adma.202006957 SN - 0935-9648 SN - 1521-4095 VL - 33 IS - 14 PB - Wiley-VCH CY - Weinheim ER - TY - GEN A1 - Kühn, Danilo A1 - Sorgenfrei, Nomi A1 - Giangrisostomi, Erika A1 - Jay, Raphael Martin A1 - Musazayb, Abdurrahman A1 - Ovsyannikov, Ruslan A1 - Stråhlman, Christian A1 - Svensson, Svante A1 - Mårtensson, Nils A1 - Föhlisch, Alexander T1 - Capabilities of angle resolved time of flight electron spectroscopy with the 60 degrees wide angle acceptance lens T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - The simultaneous detection of energy, momentum and temporal information in electron spectroscopy is the key aspect to enhance the detection efficiency in order to broaden the range of scientific applications. Employing a novel 60 degrees wide angle acceptance lens system, based on an additional accelerating electron optical element, leads to a significant enhancement in transmission over the previously employed 30 degrees electron lenses. Due to the performance gain, optimized capabilities for time resolved electron spectroscopy and other high transmission applications with pulsed ionizing radiation have been obtained. The energy resolution and transmission have been determined experimentally utilizing BESSY II as a photon source. Four different and complementary lens modes have been characterized. (C) 2017 The Authors. Published by Elsevier B.V. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 782 KW - Artof KW - electron spectroscopy KW - wide angle KW - time of flight KW - energy resolution KW - synchrotron Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-436629 SN - 1866-8372 IS - 782 SP - 45 EP - 50 ER - TY - JOUR A1 - Lehmann, Nico A1 - Kuhn, Yves-Alain A1 - Keller, Martin A1 - Aye, Norman A1 - Herold, Fabian A1 - Draganski, Bogdan A1 - Taube, Wolfgang A1 - Taubert, Marco T1 - Brain activation during active balancing and its behavioral relevance in younger and older adults BT - a functional near-infrared spectroscopy (fNIRS) study JF - Frontiers in Aging Neuroscience N2 - Age-related deterioration of balance control is widely regarded as an important phenomenon influencing quality of life and longevity, such that a more comprehensive understanding of the neural mechanisms underlying this process is warranted. Specifically, previous studies have reported that older adults typically show higher neural activity during balancing as compared to younger counterparts, but the implications of this finding on balance performance remain largely unclear. Using functional near-infrared spectroscopy (fNIRS), differences in the cortical control of balance between healthy younger (n = 27) and older (n = 35) adults were explored. More specifically, the association between cortical functional activity and balance performance across and within age groups was investigated. To this end, we measured hemodynamic responses (i.e., changes in oxygenated and deoxygenated hemoglobin) while participants balanced on an unstable device. As criterion variables for brain-behavior-correlations, we also assessed postural sway while standing on a free-swinging platform and while balancing on wobble boards with different levels of difficulty. We found that older compared to younger participants had higher activity in prefrontal and lower activity in postcentral regions. Subsequent robust regression analyses revealed that lower prefrontal brain activity was related to improved balance performance across age groups, indicating that higher activity of the prefrontal cortex during balancing reflects neural inefficiency. We also present evidence supporting that age serves as a moderator in the relationship between brain activity and balance, i.e., cortical hemodynamics generally appears to be a more important predictor of balance performance in the older than in the younger. Strikingly, we found that age differences in balance performance are mediated by balancing-induced activation of the superior frontal gyrus, thus suggesting that differential activation of this region reflects a mechanism involved in the aging process of the neural control of balance. Our study suggests that differences in functional brain activity between age groups are not a mere by-product of aging, but instead of direct behavioral relevance for balance performance. Potential implications of these findings in terms of early detection of fall-prone individuals and intervention strategies targeting balance and healthy aging are discussed. KW - aging KW - neuroimaging KW - functional near-infrared spectroscopy (fNIRS) KW - balance KW - postural control KW - prefrontal cortex KW - neural inefficiency Y1 - 2022 U6 - https://doi.org/10.3389/fnagi.2022.828474 SN - 1663-4365 VL - 14 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Kühn, Danilo A1 - Müller, Moritz A1 - Sorgenfrei, Nomi A1 - Giangrisostomi, Erika A1 - Jay, Raphael Martin A1 - Ovsyannikov, Ruslan A1 - Martensson, Nils A1 - Sanchez-Portal, Daniel A1 - Föhlisch, Alexander T1 - Directional sub-femtosecond charge transfer dynamics and the dimensionality of 1T-TaS2 JF - Scientific reports N2 - For the layered transition metal dichalcogenide 1T-TaS2, we establish through a unique experimental approach and density functional theory, how ultrafast charge transfer in 1T-TaS2 takes on isotropic three-dimensional character or anisotropic two-dimensional character, depending on the commensurability of the charge density wave phases of 1T-TaS2. The X-ray spectroscopic core-hole-clock method prepares selectively in-and out-of-plane polarized sulfur 3p orbital occupation with respect to the 1T-TaS2 planes and monitors sub-femtosecond wave packet delocalization. Despite being a prototypical two-dimensional material, isotropic three-dimensional charge transfer is found in the commensurate charge density wave phase (CCDW), indicating strong coupling between layers. In contrast, anisotropic two-dimensional charge transfer occurs for the nearly commensurate phase (NCDW). In direct comparison, theory shows that interlayer interaction in the CCDW phase - not layer stacking variations - causes isotropic three-dimensional charge transfer. This is presumably a general mechanism for phase transitions and tailored properties of dichalcogenides with charge density waves. Y1 - 2019 U6 - https://doi.org/10.1038/s41598-018-36637-0 SN - 2045-2322 VL - 9 IS - 488 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Kühn, Danilo A1 - Giangrisostomi, Erika A1 - Jay, Raphael Martin A1 - Sorgenfrei, Nomi A1 - Föhlisch, Alexander T1 - The influence of x-ray pulse length on space-charge effects in optical pump/x-ray probe photoemission JF - New journal of physics : the open-access journal for physics N2 - Pump-probe photoelectron spectroscopy (PES) is a versatile tool to investigate the dynamics of transient states of excited matter. Vacuum space-charge effects can mask these dynamics and complicate the interpretation of electron spectra. Here we report on space-charge effects in Au 4f photoemission from a polycrystalline gold surface, excited with moderately intense 90 ps (FWHM) soft x-ray probe pulses, under the influence of the Coulomb forces exerted by a pump electron cloud, which was produced by intense 40 fs laser pulses. The experimentally observed kinetic energy shift and spectral broadening of the Au 4f lines, measured with highly-efficient time-of-flight spectroscopy, are in good agreement with simulations utilizing a mean-field model of the electrostatic pump electron potential. This confirms that the line broadening is predominantly caused by variations in the take-off time of the probe electrons without appreciable influence of local scattering events. Our findings might be of general interest for pump-probe PES with picosecond-pulse-length sources. KW - space-charge effects KW - mean-field model KW - x-ray photoemission KW - electron spectroscopy KW - pump-probe KW - ARTOF Y1 - 2019 U6 - https://doi.org/10.1088/1367-2630/ab2f5c SN - 1367-2630 VL - 21 PB - IOP Publ. Ltd. CY - Bristol ER - TY - GEN A1 - Wuertz-Kozak, Karin A1 - Roszkowski, Martin A1 - Cambria, Elena A1 - Block, Andrea A1 - Kuhn, Gisela A. A1 - Abele, Thea A1 - Hitzl, Wolfgang A1 - Drießlein, David A1 - Müller, Ralph A1 - Rapp, Michael A. A1 - Mansuy, Isabelle M. A1 - Peters, Eva M. J. A1 - Wippert, Pia-Maria T1 - Effects of Early Life Stress on Bone Homeostasis in Mice and Humans T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 670 KW - psychosocial stress KW - bone pathologies KW - osteoporosis KW - bone mineral density KW - childhood KW - neuroendocrine Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485324 SN - 1866-8364 IS - 670 ER - TY - JOUR A1 - Wuertz-Kozak, Karin A1 - Roszkowski, Martin A1 - Cambria, Elena A1 - Block, Andrea A1 - Kuhn, Gisela A. A1 - Abele, Thea A1 - Hitzl, Wolfgang A1 - Drießlein, David A1 - Müller, Ralph A1 - Rapp, Michael A. A1 - Mansuy, Isabelle M. A1 - Peters, Eva M. J. A1 - Wippert, Pia-Maria T1 - Effects of Early Life Stress on Bone Homeostasis in Mice and Humans JF - International Journal of Molecular Sciences N2 - Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies. KW - psychosocial stress KW - bone pathologies KW - osteoporosis KW - bone mineral density KW - childhood KW - neuroendocrine Y1 - 2020 U6 - https://doi.org/10.3390/ijms21186634 SN - 1422-0067 VL - 21 IS - 18 PB - Molecular Diversity Preservation International CY - Basel ER -