TY  - JOUR
A1  - Lieckfeldt, Elke
A1  - Simon-Rosin, Ulrike
A1  - Zöller, Daniela
A1  - Ebert, Berit
A1  - Kehr, Julia
A1  - Fisahn, Joachim
T1  - Spatio/temporal analysis of gene exression profiles within single cells and specific tissue types of developing Arabidopsis plants
Y1  - 2004
SN  - 3-00-011587-0
ER  - 
TY  - JOUR
A1  - Zoller, Peter
A1  - Beth, Thomas
A1  - Binosi, D.
A1  - Blatt, Rainer
A1  - Briegel, Hans J.
A1  - Bruss, D.
A1  - Calarco, Tommaso
A1  - Cirac, Juan Ignacio
A1  - Deutsch, David
A1  - Eisert, Jens
A1  - Ekert, Artur
A1  - Fabre, Claude
A1  - Gisin, Nicolas
A1  - Grangiere, P.
A1  - Grassl, Markus
A1  - Haroche, Serge
A1  - Imamoglu, Atac
A1  - Karlson, A.
A1  - Kempe, Julia
A1  - Kouwenhoven, Leo P.
A1  - Kröll, S.
A1  - Leuchs, Gerd
A1  - Lewenstein, Maciej
A1  - Loss, Daniel
A1  - Lütkenhaus, Norbert
A1  - Massar, Serge
A1  - Mooij, J. E.
A1  - Plenio, Martin Bodo
A1  - Polzik, Eugene
A1  - Popescu, Sandu
A1  - Rempe, Gerhard
A1  - Sergienko, Alexander
A1  - Suter, David
A1  - Twamley, John
A1  - Wendin, Göran
A1  - Werner, Reinhard F.
A1  - Winter, Andreas
A1  - Wrachtrup, Jörg
A1  - Zeilinger, Anton
T1  - Quantum information processing and communication : Strategic report on current status, visions and goals for research in Europe
N2  - We present an excerpt of the document "Quantum Information Processing and Communication: Strategic report on current status, visions and goals for research in Europe", which has been recently published in electronic form at the website of FET (the Future and Emerging Technologies Unit of the Directorate General Information Society of the European Commission, http://www.cordis.lu/ist/fet/qipc-sr.htm). This document has been elaborated, following a former suggestion by FET, by a committee of QIPC scientists to provide input towards the European Commission for the preparation of the Seventh Framework Program. Besides being a document addressed to policy makers and funding agencies (both at the European and national level), the document contains a detailed scientific assessment of the state-of-the-art, main research goals, challenges, strengths, weaknesses, visions and perspectives of all the most relevant QIPC sub-fields, that we report here
Y1  - 2005
SN  - 1434-6060
ER  - 
TY  - JOUR
A1  - Meiners, Jana
A1  - Palmieri, Vittoria
A1  - Klopfleisch, Robert
A1  - Ebel, Jana-Fabienne
A1  - Japtok, Lukasz
A1  - Schumacher, Fabian
A1  - Yusuf, Ayan Mohamud
A1  - Becker, Katrin Anne
A1  - Zöller, Julia
A1  - Hose, Matthias
A1  - Kleuser, Burkhard
A1  - Hermann, Dirk Matthias
A1  - Kolesnick, Richard N.
A1  - Buer, Jan
A1  - Hansen, Wiebke
A1  - Westendorf, Astrid M.
T1  - Intestinal acid sphingomyelinase protects from severe Pathogen-Driven Colitis
JF  - Frontiers in immunology
N2  - Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to contribute to its pathogenesis. In the present study, we determined the impact of acid sphingomyelinase (Asm), which catalyzes the hydrolysis of sphingomyelin to ceramide, on the course of Citrobacter (C.) rodentium-driven colitis. C. rodentium is an enteric pathogen and induces colonic inflammation very similar to the pathology in patients with ulcerative colitis. We found that mice with Asm deficiency or Asm inhibition were strongly susceptible to C. rodentium infection. These mice showed increased levels of C. rodentium in the feces and were prone to bacterial spreading to the systemic organs. In addition, mice lacking Asm activity showed an uncontrolled inflammatory T(h)1 and T(h)17 response, which was accompanied by a stronger colonic pathology compared to infected wild type mice. These findings identified Asm as an essential regulator of mucosal immunity to the enteric pathogen C. rodentium.
KW  - Citrobacter rodentium
KW  - colitis
KW  - acid sphingomyelinase
KW  - amitriptyline
KW  - T(h)1
KW  - T(h)17
Y1  - 2019
U6  - https://doi.org/10.3389/fimmu.2019.01386
SN  - 1664-3224
VL  - 10
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -