TY  - JOUR
A1  - Chen, Shun-Gang
A1  - Li, Ji
A1  - Zhang, Fan
A1  - Xiao, Bo
A1  - Hu, Jia-Ming
A1  - Cui, Yin-Qiu
A1  - Hofreiter, Michael
A1  - Hou, Xin-Dong
A1  - Sheng, Gui-Lian
A1  - Lai, Xu-Long
A1  - Yuan, Jun-Xia
T1  - Different maternal lineages revealed by ancient mitochondrial genome of Camelus bactrianus from China
JF  - Mitochondrial DNA Part A
N2  - Domestic Bactrian camel (Camelus bactrianus) used to be one of the most important livestock species in Chinese history, as well as the major transport carrier on the ancient Silk Road. However, archeological studies on Chinese C. bactrianus are still limited, and molecular biology research on this species is mainly focused on modern specimens. In this study, we retrieved the complete mitochondrial genome from a C. bactrianus specimen, which was excavated from northwestern China and dated at 1290-1180 cal. Phylogenetic analyses using 18 mitochondrial genomes indicated that the C. bactrianus clade was divided into two maternal lineages. The majority of samples originating from Iran to Japan and Mongolia belong to subclade A1, while our sample together with two Mongolian individuals formed the much smaller subclade A2. Furthermore, the divergence time of these two maternal lineages was estimated as 165 Kya (95% credibility interval 117-222 Kya), this might indicate that several different evolutionary lineages were incorporated into the domestic gene pool during the initial domestication process. Bayesian skyline plot (BSP) analysis a slow increase in female effective population size of C. bactrianus from 5000 years ago, which to the beginning of domestication of C. bactrianus. The present study also revealed that there were extensive exchanges of genetic information among C. bactrianus populations in regions along the Silk Road.
KW  - Camelus bactrianus
KW  - mitochondrial genome
KW  - ancient DNA
KW  - phylogeny
KW  - maternal lineages
Y1  - 2019
U6  - https://doi.org/10.1080/24701394.2019.1659250
SN  - 2470-1394
SN  - 2470-1408
VL  - 30
IS  - 7
SP  - 786
EP  - 793
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Yang, Guang
A1  - Zheng, Wei
A1  - Tao, Guoqing
A1  - Wu, Libin
A1  - Zhou, Qi-Feng
A1  - Kochovski, Zdravko
A1  - Ji, Tan
A1  - Chen, Huaijun
A1  - Li, Xiaopeng
A1  - Lu, Yan
A1  - Ding, Hong-ming
A1  - Yang, Hai-Bo
A1  - Chen, Guosong
A1  - Jiang, Ming
T1  - Diversiform and Transformable Glyco-Nanostructures Constructed from Amphiphilic Supramolecular Metallocarbohydrates through Hierarchical Self-Assembly: The Balance between Metallacycles and Saccharides
JF  - ACS nano
N2  - During the past decade, self-assembly of saccharide-containing amphiphilic molecules toward bioinspired functional glycomaterials has attracted continuous attention due to their various applications in fundamental and practical areas. However, it still remains a great challenge to prepare hierarchical glycoassemblies with controllable and diversiform structures because of the complexity of saccharide structures and carbohydrate-carbohydrate interactions. Herein, through hierarchical self-assembly of modulated amphiphilic supramolecular metallocarbohydrates, we successfully prepared various well-defined glyco-nanostructures in aqueous solution, including vesicles, solid spheres, and opened vesicles depending on the molecular structures of metallocarbohydrates. More attractively, these glyco-nanostructures can further transform into other morphological structures in aqueous solutions such as worm-like micelles, tubules, and even tupanvirus-like vesicles (TVVs). It is worth mentioning that distinctive anisotropic structures including the opened vesicles (OVs) and TVVs were rarely reported in glycobased nano-objects. This intriguing diversity was mainly controlled by the subtle structural trade-off of the two major components of the amphiphiles, i.e., the saccharides and metallacycles. To further understand this precise structural control, molecular simulations provided deep physical insights on the morphology evolution and balancing of the contributions from saccharides and metallacycles. Moreover, the multivalency of glyco-nanostructures with different shapes and sizes was demonstrated by agglutination with a diversity of sugarbinding protein receptors such as the plant lectins Concanavalin A (ConA). This modular synthesis strategy provides access to systematic tuning of molecular structure and self-assembled architecture, which undoubtedly will broaden our horizons on the controllable fabrication of biomimetic glycomaterials such as biological membranes and supramolecular lectin inhibitors.
KW  - glycomaterials
KW  - diversiform structures
KW  - hierarchical self-assembly
KW  - metallocarbohydrates
KW  - anisotropic structures
Y1  - 2019
U6  - https://doi.org/10.1021/acsnano.9b07134
SN  - 1936-0851
SN  - 1936-086X
VL  - 13
IS  - 11
SP  - 13474
EP  - 13485
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Chen, You-Peng
A1  - Li, Jian
A1  - Wang, Zi-Neng
A1  - Reichetzeder, Christoph
A1  - Xu, Hao
A1  - Gong, Jian
A1  - Chen, Guang-Ji
A1  - Pfab, Thiemo
A1  - Xiao, Xiao-Min
A1  - Hocher, Berthold
T1  - Renin angiotensin aldosterone system and glycemia in pregnancy
JF  - Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion
N2  - Background: The renin-angiotensin-aldosterone system (RAAS) is involved in the pathogenesis of insulin resistance and type 2 diabetes in the general population. The RAAS is activated during pregnancy. However, it is unknown whether the RAAS contributes to glycemia in pregnant women.
 Methods: Plasma renin activity (PRA) and plasma aldosterone levels were quantified at delivery in 689 Chinese mothers. An oral glucose tolerance test in fasted women was performed in the second trimester of pregnancy. The diagnosis of gestational diabetes mellitus (GDM) and impaired glucose tolerance during pregnancy were made according to the guidelines of the Chinese Society of Obstetrics.
 Results: Plasma aldosterone was significantly higher in pregnant women with GDM as compared to those without impairment of glycemic control (normal pregnancies: 0.27 +/- 0.21 ng/mL, GDM: 0.36 +/- 0.30 ng/mL; p<0.05). Regression analyses revealed that PRA was negatively correlated with fasting blood glucose (FBG) (R-2 = 0.03, p = 0.007), whereas plasma aldosterone and aldosterone/PRA ratio were positively correlated with FBG (R-2 = 0.05, p<0.001 and R-2 = 0.03, p = 0.007, respectively). Multivariable regression analysis models considering relevant confounding factors confirmed these findings.
 Conclusions: This study demonstrated that fasting blood glucose in pregnant women is inversely correlated with the PRA, whereas plasma aldosterone showed a highly significant positive correlation with fasting blood glucose during pregnancy. Moreover, plasma aldosterone is significantly higher in pregnant women with GDM as compared to those women with normal glucose tolerance during pregnancy. Although causality cannot be proven in association studies, these data may indicate that the RAAS during pregnancy contributes to the pathogenesis of insulin resistance/new onset of diabetes during pregnancy.
KW  - Renin-angiotensin-aldosterone system
KW  - pregnancy
KW  - fasting blood glucose
KW  - glycemic control
Y1  - 2012
SN  - 1433-6510
VL  - 58
IS  - 5-6
SP  - 527
EP  - 533
PB  - Clin Lab Publ., Verl. Klinisches Labor
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Kumar, Pankaj
A1  - Gale, Stephan W.
A1  - Kocyan, Alexander
A1  - Fischer, Gunter A.
A1  - Averyanov, Leonid
A1  - Borosova, Renata
A1  - Bhattacharjee, Avishek
A1  - Li, Ji-Hong
A1  - Pang, Kuen Shum
T1  - Gastrochilus kadooriei (Orchidaceae), a new species from Hong Kong, with notes on allied taxa in section Microphyllae found in the region
JF  - Phytotaxa : a rapid international journal for accelerating the publication of botanical taxonomy
N2  - A new species, Gastrochilus kadooriei, is described from Hong Kong. Notes are presented on its distribution, ecology and conservation status, and its distinguishing features are compared with those of allied taxa. Gastrochilus jeitouensis is reduced to the synonymy of G. distichus, and a lectotype is assigned for G. pseudodistichus. Gastrochilus fuscopunctatus is reinstated as an accepted species. Dichotomous keys to this taxonomically difficult group of morphologically similar species are presented.
Y1  - 2014
SN  - 1179-3155
SN  - 1179-3163
VL  - 164
IS  - 2
SP  - 91
EP  - 103
PB  - Magnolia Press
CY  - Auckland
ER  -