TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Diluiso, Francesca
A1  - Walk, Paula
A1  - Manych, Niccolo
A1  - Cerutti, Nicola
A1  - Chipiga, Vladislav
A1  - Workman, Annabelle
A1  - Ayas, Ceren
A1  - Cui, Ryna Yiyun
A1  - Cui, Diyang
A1  - Song, Kaihui
A1  - Banisch, Lucy A.
A1  - Moretti, Nikolaj
A1  - Callaghan, Max W.
A1  - Clarke, Leon
A1  - Creutzig, Felix
A1  - Hilaire, Jerome
A1  - Jotzo, Frank
A1  - Kalkuhl, Matthias
A1  - Lamb, William F.
A1  - Löschel, Andreas
A1  - Müller-Hansen, Finn
A1  - Nemet, Gregory F.
A1  - Oei, Pao-Yu
A1  - Sovacool, Benjamin K.
A1  - Steckel, Jan Christoph
A1  - Thomas, Sebastian
A1  - Wiseman, John
A1  - Minx, Jan C.
T1  - Coal transitions - part 1
BT  - a systematic map and review of case study learnings from regional, national, and local coal phase-out experiences
JF  - Environmental research letters
N2  - A rapid coal phase-out is needed to meet the goals of the Paris Agreement, but is hindered by serious challenges ranging from vested interests to the risks of social disruption. To understand how to organize a global coal phase-out, it is crucial to go beyond cost-effective climate mitigation scenarios and learn from the experience of previous coal transitions. Despite the relevance of the topic, evidence remains fragmented throughout different research fields, and not easily accessible. To address this gap, this paper provides a systematic map and comprehensive review of the literature on historical coal transitions. We use computer-assisted systematic mapping and review methods to chart and evaluate the available evidence on historical declines in coal production and consumption. We extracted a dataset of 278 case studies from 194 publications, covering coal transitions in 44 countries and ranging from the end of the 19th century until 2021. We find a relatively recent and rapidly expanding body of literature reflecting the growing importance of an early coal phase-out in scientific and political debates. Previous evidence has primarily focused on the United Kingdom, the United States, and Germany, while other countries that experienced large coal declines, like those in Eastern Europe, are strongly underrepresented. An increasing number of studies, mostly published in the last 5 years, has been focusing on China. Most of the countries successfully reducing coal dependency have undergone both demand-side and supply-side transitions. This supports the use of policy approaches targeting both demand and supply to achieve a complete coal phase-out. From a political economy perspective, our dataset highlights that most transitions are driven by rising production costs for coal, falling prices for alternative energies, or local environmental concerns, especially regarding air pollution. The main challenges for coal-dependent regions are structural change transformations, in particular for industry and labor. Rising unemployment is the most largely documented outcome in the sample. Policymakers at multiple levels are instrumental in facilitating coal transitions. They rely mainly on regulatory instruments to foster the transitions and compensation schemes or investment plans to deal with their transformative processes. Even though many models suggest that coal phase-outs are among the low-hanging fruits on the way to climate neutrality and meeting the international climate goals, our case studies analysis highlights the intricate political economy at work that needs to be addressed through well-designed and just policies.
KW  - climate change mitigation
KW  - coal transitions
KW  - evidence synthesis
KW  - political economy
KW  - systematic map
Y1  - 2021
U6  - https://doi.org/10.1088/1748-9326/ac1b58
SN  - 1748-9326
VL  - 16
IS  - 11
PB  - Institute of Physics Publishing (IOP)
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Warrington, Nicole
A1  - Beaumont, Robin
A1  - Horikoshi, Momoko
A1  - Day, Felix R.
A1  - Helgeland, Øyvind
A1  - Laurin, Charles
A1  - Bacelis, Jonas
A1  - Peng, Shouneng
A1  - Hao, Ke
A1  - Feenstra, Bjarke
A1  - Wood, Andrew R.
A1  - Mahajan, Anubha
A1  - Tyrrell, Jessica
A1  - Robertson, Neil R.
A1  - Rayner, N. William
A1  - Qiao, Zhen
A1  - Moen, Gunn-Helen
A1  - Vaudel, Marc
A1  - Marsit, Carmen
A1  - Chen, Jia
A1  - Nodzenski, Michael
A1  - Schnurr, Theresia M.
A1  - Zafarmand, Mohammad Hadi
A1  - Bradfield, Jonathan P.
A1  - Grarup, Niels
A1  - Kooijman, Marjolein N.
A1  - Li-Gao, Ruifang
A1  - Geller, Frank
A1  - Ahluwalia, Tarunveer Singh
A1  - Paternoster, Lavinia
A1  - Rueedi, Rico
A1  - Huikari, Ville
A1  - Hottenga, Jouke-Jan
A1  - Lyytikäinen, Leo-Pekka
A1  - Cavadino, Alana
A1  - Metrustry, Sarah
A1  - Cousminer, Diana L.
A1  - Wu, Ying
A1  - Thiering, Elisabeth Paula
A1  - Wang, Carol A.
A1  - Have, Christian Theil
A1  - Vilor-Tejedor, Natalia
A1  - Joshi, Peter K.
A1  - Painter, Jodie N.
A1  - Ntalla, Ioanna
A1  - Myhre, Ronny
A1  - Pitkänen, Niina
A1  - van Leeuwen, Elisabeth M.
A1  - Joro, Raimo
A1  - Lagou, Vasiliki
A1  - Richmond, Rebecca C.
A1  - Espinosa, Ana
A1  - Barton, Sheila J.
A1  - Inskip, Hazel M.
A1  - Holloway, John W.
A1  - Santa-Marina, Loreto
A1  - Estivill, Xavier
A1  - Ang, Wei
A1  - Marsh, Julie A.
A1  - Reichetzeder, Christoph
A1  - Marullo, Letizia
A1  - Hocher, Berthold
A1  - Lunetta, Kathryn L.
A1  - Murabito, Joanne M.
A1  - Relton, Caroline L.
A1  - Kogevinas, Manolis
A1  - Chatzi, Leda
A1  - Allard, Catherine
A1  - Bouchard, Luigi
A1  - Hivert, Marie-France
A1  - Zhang, Ge
A1  - Muglia, Louis J.
A1  - Heikkinen, Jani
A1  - Morgen, Camilla S.
A1  - van Kampen, Antoine H. C.
A1  - van Schaik, Barbera D. C.
A1  - Mentch, Frank D.
A1  - Langenberg, Claudia
A1  - Scott, Robert A.
A1  - Zhao, Jing Hua
A1  - Hemani, Gibran
A1  - Ring, Susan M.
A1  - Bennett, Amanda J.
A1  - Gaulton, Kyle J.
A1  - Fernandez-Tajes, Juan
A1  - van Zuydam, Natalie R.
A1  - Medina-Gomez, Carolina
A1  - de Haan, Hugoline G.
A1  - Rosendaal, Frits R.
A1  - Kutalik, Zoltán
A1  - Marques-Vidal, Pedro
A1  - Das, Shikta
A1  - Willemsen, Gonneke
A1  - Mbarek, Hamdi
A1  - Müller-Nurasyid, Martina
A1  - Standl, Marie
A1  - Appel, Emil V. R.
A1  - Fonvig, Cilius Esmann
A1  - Trier, Caecilie
A1  - van Beijsterveldt, Catharina E. M.
A1  - Murcia, Mario
A1  - Bustamante, Mariona
A1  - Bonàs-Guarch, Sílvia
A1  - Hougaard, David M.
A1  - Mercader, Josep M.
A1  - Linneberg, Allan
A1  - Schraut, Katharina E.
A1  - Lind, Penelope A.
A1  - Medland, Sarah Elizabeth
A1  - Shields, Beverley M.
A1  - Knight, Bridget A.
A1  - Chai, Jin-Fang
A1  - Panoutsopoulou, Kalliope
A1  - Bartels, Meike
A1  - Sánchez, Friman
A1  - Stokholm, Jakob
A1  - Torrents, David
A1  - Vinding, Rebecca K.
A1  - Willems, Sara M.
A1  - Atalay, Mustafa
A1  - Chawes, Bo L.
A1  - Kovacs, Peter
A1  - Prokopenko, Inga
A1  - Tuke, Marcus A.
A1  - Yaghootkar, Hanieh
A1  - Ruth, Katherine S.
A1  - Jones, Samuel E.
A1  - Loh, Po-Ru
A1  - Murray, Anna
A1  - Weedon, Michael N.
A1  - Tönjes, Anke
A1  - Stumvoll, Michael
A1  - Michaelsen, Kim Fleischer
A1  - Eloranta, Aino-Maija
A1  - Lakka, Timo A.
A1  - van Duijn, Cornelia M.
A1  - Kiess, Wieland
A1  - Koerner, Antje
A1  - Niinikoski, Harri
A1  - Pahkala, Katja
A1  - Raitakari, Olli T.
A1  - Jacobsson, Bo
A1  - Zeggini, Eleftheria
A1  - Dedoussis, George V.
A1  - Teo, Yik-Ying
A1  - Saw, Seang-Mei
A1  - Montgomery, Grant W.
A1  - Campbell, Harry
A1  - Wilson, James F.
A1  - Vrijkotte, Tanja G. M.
A1  - Vrijheid, Martine
A1  - de Geus, Eco J. C. N.
A1  - Hayes, M. Geoffrey
A1  - Kadarmideen, Haja N.
A1  - Holm, Jens-Christian
A1  - Beilin, Lawrence J.
A1  - Pennell, Craig E.
A1  - Heinrich, Joachim
A1  - Adair, Linda S.
A1  - Borja, Judith B.
A1  - Mohlke, Karen L.
A1  - Eriksson, Johan G.
A1  - Widen, Elisabeth E.
A1  - Hattersley, Andrew T.
A1  - Spector, Tim D.
A1  - Kaehoenen, Mika
A1  - Viikari, Jorma S.
A1  - Lehtimaeki, Terho
A1  - Boomsma, Dorret I.
A1  - Sebert, Sylvain
A1  - Vollenweider, Peter
A1  - Sorensen, Thorkild I. A.
A1  - Bisgaard, Hans
A1  - Bonnelykke, Klaus
A1  - Murray, Jeffrey C.
A1  - Melbye, Mads
A1  - Nohr, Ellen A.
A1  - Mook-Kanamori, Dennis O.
A1  - Rivadeneira, Fernando
A1  - Hofman, Albert
A1  - Felix, Janine F.
A1  - Jaddoe, Vincent W. V.
A1  - Hansen, Torben
A1  - Pisinger, Charlotta
A1  - Vaag, Allan A.
A1  - Pedersen, Oluf
A1  - Uitterlinden, Andre G.
A1  - Jarvelin, Marjo-Riitta
A1  - Power, Christine
A1  - Hypponen, Elina
A1  - Scholtens, Denise M.
A1  - Lowe, William L.
A1  - Smith, George Davey
A1  - Timpson, Nicholas J.
A1  - Morris, Andrew P.
A1  - Wareham, Nicholas J.
A1  - Hakonarson, Hakon
A1  - Grant, Struan F. A.
A1  - Frayling, Timothy M.
A1  - Lawlor, Debbie A.
A1  - Njolstad, Pal R.
A1  - Johansson, Stefan
A1  - Ong, Ken K.
A1  - McCarthy, Mark I.
A1  - Perry, John R. B.
A1  - Evans, David M.
A1  - Freathy, Rachel M.
T1  - Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
JF  - Nature genetics
N2  - Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Y1  - 2019
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 5
SP  - 804
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - CHAP
A1  - Curzon, Paul
A1  - Kalas, Ivan
A1  - Schubert, Sigrid
A1  - Schaper, Niclas
A1  - Barnes, Jan
A1  - Kennewell, Steve
A1  - Bröker, Kathrin
A1  - Kastens, Uwe
A1  - Magenheim, Johannes
A1  - Dagiene, Valentina
A1  - Stupuriene, Gabriele
A1  - Ellis, Jason Brent
A1  - Abreu-Ellis, Carla Reis
A1  - Grillenberger, Andreas
A1  - Romeike, Ralf
A1  - Haugsbakken, Halvdan
A1  - Jones, Anthony
A1  - Lewin, Cathy
A1  - McNicol, Sarah
A1  - Nelles, Wolfgang
A1  - Neugebauer, Jonas
A1  - Ohrndorf, Laura
A1  - Schaper, Niclas
A1  - Schubert, Sigrid
A1  - Opel, Simone
A1  - Kramer, Matthias
A1  - Trommen, Michael
A1  - Pottbäcker, Florian
A1  - Ilaghef, Youssef
A1  - Passig, David
A1  - Tzuriel, David
A1  - Kedmi, Ganit Eshel
A1  - Saito, Toshinori
A1  - Webb, Mary
A1  - Weigend, Michael
A1  - Bottino, Rosa
A1  - Chioccariello, Augusto
A1  - Christensen, Rhonda
A1  - Knezek, Gerald
A1  - Gioko, Anthony Maina
A1  - Angondi, Enos Kiforo
A1  - Waga, Rosemary
A1  - Ohrndorf, Laura
A1  - Or-Bach, Rachel
A1  - Preston, Christina
A1  - Younie, Sarah
A1  - Przybylla, Mareen
A1  - Romeike, Ralf
A1  - Reynolds, Nicholas
A1  - Swainston, Andrew
A1  - Bendrups, Faye
A1  - Sysło, Maciej M.
A1  - Kwiatkowska, Anna Beata
A1  - Zieris, Holger
A1  - Gerstberger, Herbert
A1  - Müller, Wolfgang
A1  - Büchner, Steffen
A1  - Opel, Simone
A1  - Schiller, Thomas
A1  - Wegner, Christian
A1  - Zender, Raphael
A1  - Lucke, Ulrike
A1  - Diethelm, Ira
A1  - Syrbe, Jörn
A1  - Lai, Kwok-Wing
A1  - Davis, Niki
A1  - Eickelmann, Birgit
A1  - Erstad, Ola
A1  - Fisser, Petra
A1  - Gibson, David
A1  - Khaddage, Ferial
A1  - Knezek, Gerald
A1  - Micheuz, Peter
A1  - Kloos, Carlos Delgado
ED  - Brinda, Torsten
ED  - Reynolds, Nicholas
ED  - Romeike, Ralf
ED  - Schwill, Andreas
T1  - KEYCIT 2014
BT  - key competencies in informatics and ICT
N2  - In our rapidly changing world it is increasingly important not only to be an expert in a chosen field of study but also to be able to respond to developments, master new approaches to solving problems, and fulfil changing requirements in the modern world and in the job market. In response to these needs key competencies in understanding, developing and using new digital technologies are being brought into focus in school and university programmes. The IFIP TC3 conference "KEYCIT – Key Competences in Informatics and ICT (KEYCIT 2014)" was held at the University of Potsdam in Germany from July 1st to 4th, 2014 and addressed the combination of key competencies, Informatics and ICT in detail. The conference was organized into strands focusing on secondary education, university education and teacher education (organized by IFIP WGs 3.1 and 3.3) and provided a forum to present and to discuss research, case studies, positions, and national perspectives in this field.
T3  - Commentarii informaticae didacticae (CID) - 7 
KW  - Schlüsselkompetenzen
KW  - Informatik
KW  - Bildung
KW  - ICT
KW  - Informatikdidaktik
KW  - Key Competencies
KW  - Informatics
KW  - education
KW  - ICT
KW  - Computer Science Education
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-70325
SN  - 978-3-86956-292-6
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Sorkau, Elisabeth
A1  - Boch, Steffen
A1  - Boeddinghaus, Runa S.
A1  - Bonkowski, Michael
A1  - Fischer, Markus
A1  - Kandeler, Ellen
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Marhan, Sven
A1  - Müller, Jörg
A1  - Prati, Daniel
A1  - Schoening, Ingo
A1  - Schrumpf, Marion
A1  - Weinert, Jan
A1  - Oelmann, Yvonne
T1  - The role of soil chemical properties, land use and plant diversity for microbial phosphorus in forest and grassland soils
JF  - Journal of plant nutrition and soil science = Zeitschrift für Pflanzenernährung und Bodenkunde
N2  - Management intensity modifies soil properties, e.g., organic carbon (C-org) concentrations and soil pH with potential feedbacks on plant diversity. These changes might influence microbial P concentrations (P-mic) in soil representing an important component of the Pcycle. Our objectives were to elucidate whether abiotic and biotic variables controlling P-mic concentrations in soil are the same for forests and grasslands, and to assess the effect of region and management on P-mic concentrations in forest and grassland soils as mediated by the controlling variables. In three regions of Germany, Schwabische Alb, Hanich-Dun, and Schorfheide-Chorin, we studied forest and grassland plots (each n=150) differing in plant diversity and land-use intensity. In contrast to controls of microbial biomass carbon (C-mic), P-mic was strongly influenced by soil pH, which in turn affected phosphorus (P) availability and thus microbial Puptake in forest and grassland soils. Furthermore, P-mic concentrations in forest and grassland soils increased with increasing plant diversity. Using structural equation models, we could show that soil C-org is the profound driver of plant diversity effects on P-mic in grasslands. For both forest and grassland, we found regional differences in P-mic attributable to differing environmental conditions (pH, soil moisture). Forest management and tree species showed no effect on P-mic due to a lack of effects on controlling variables (e.g., C-org). We also did not find management effects in grassland soils which might be caused by either compensation of differently directed effects across sites or by legacy effects of former fertilization constraining the relevance of actual practices. We conclude that variables controlling P-mic or C-mic in soil differ in part and that regional differences in controlling variables are more important for P-mic in soil than those induced by management.
KW  - age class forest
KW  - land-use intensity
KW  - meadow
KW  - microbes
KW  - pasture
KW  - unmanaged forest
Y1  - 2018
U6  - https://doi.org/10.1002/jpln.201700082
SN  - 1436-8730
SN  - 1522-2624
VL  - 181
IS  - 2
SP  - 185
EP  - 197
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Heinisch, Isabelle
A1  - Romeike, Ralf
A1  - Knobelsdorf, Maria
A1  - Kreitz, Christoph
A1  - Nylén, Aletta
A1  - Dörge, Christina
A1  - Göttel, Timo
A1  - Holz, Jan
A1  - Bergner, Nadine
A1  - Schroeder, Ulrik
A1  - Metzger, Christiane
A1  - Haag, Johann
A1  - Abke, Jörg
A1  - Schwirtlich, Vincent
A1  - Sedelmaier, Yvonne
A1  - Müller, Dorothee
A1  - Frommer, Andreas
A1  - Humbert, Ludger
A1  - Berges, Marc
A1  - Mühling, Andreas
A1  - Hubwieser, Peter
A1  - Steuer, Horst
A1  - Engbring, Dieter
A1  - Selke, Harald
A1  - Drews, Paul
A1  - Schirmer, Ingrid
A1  - Morisse, Marcel
A1  - Sagawe, Arno
A1  - Rolf, Arno
A1  - Friedemann, Stefan
A1  - Gröger, Stefan
A1  - Schumann, Matthias
A1  - Klinger, Melanie
A1  - Polutina, Olena
A1  - Bibel, Ariane
A1  - Götz, Christian
A1  - Brinda, Torsten
A1  - Apel, Rebecca
A1  - Berg, Tobias
A1  - Bergner, Nadine
A1  - Chatti, Mohamed Amine
A1  - Leicht-Scholten, Carmen
A1  - Schroeder, Ulrik
A1  - Al-Saffar, Loay Talib
A1  - Petre, Marian
A1  - Schirmer, Ingrid
A1  - Rick, Detlef
ED  - Forbrig, Peter
ED  - Rick, Detlef
ED  - Schmolitzky, Axel
T1  - HDI 2012 – Informatik für eine nachhaltige Zukunft : 5. Fachtagung Hochschuldidaktik der Informatik ; 06.–07. November 2012, Universität Hamburg
N2  - Die Tagungsreihe zur Hochschuldidaktik der Informatik HDI wird vom Fachbereich Informatik und Ausbildung / Didaktik der Informatik (IAD) in der Gesellschaft für Informatik e. V. (GI) organisiert. Sie dient den Lehrenden der Informatik in Studiengängen an Hochschulen als Forum der Information und des Austauschs über neue didaktische Ansätze und bildungspolitische Themen im Bereich der Hochschulausbildung aus der fachlichen Perspektive der Informatik. Diese fünfte HDI 2012 wurde an der Universität Hamburg organisiert. Für sie wurde das spezielle Motto „Informatik für eine nachhaltige Zukunft“ gewählt, um insbesondere Fragen der Bildungsrelevanz informatischer Inhalte, der Kompetenzen für Studierende informatisch geprägter Studiengänge und der Rolle der Informatik in der Hochschulentwicklung zu diskutieren.
T3  - Commentarii informaticae didacticae (CID) - 5 
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-62891
SN  - 978-3-86956-220-9
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Nunez Valdez, Maribel
A1  - Efthimiopoulos, Ilias
A1  - Taran, Michail
A1  - Mueller, Jan
A1  - Bykova, Elena
A1  - McCammon, Catherine
A1  - Koch-Müller, Monika
A1  - Wilke, Max
T1  - Evidence for a pressure-induced spin transition in olivine-type LiFePO4 triphylite
JF  - Physical review : B, Condensed matter and materials physics
N2  - We present a combination of first-principles and experimental results regarding the structural and magnetic properties of olivine-type LiFePO4 under pressure. Our investigations indicate that the starting Pbnm phase of LiFePO4 persists up to 70 GPa. Further compression leads to an isostructural transition in the pressure range of 70-75 GPa, inconsistent with a former theoretical study. Considering our first-principles prediction for a high-spin to low-spin transition of Fe2+ close to 72 GPa, we attribute the experimentally observed isostructural transition to a change in the spin state of Fe2+ in LiFePO4. Compared to relevant Fe-bearing minerals, LiFePO4 exhibits the largest onset pressure for a pressure-induced spin state transition.
Y1  - 2018
U6  - https://doi.org/10.1103/PhysRevB.97.184405
SN  - 2469-9950
SN  - 2469-9969
VL  - 97
IS  - 18
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Lonnemann, Jan
A1  - Müller, Christian
A1  - Büttner, Gerhard
A1  - Hasselhorn, Marcus
T1  - The influence of visual-spatial skills on the association between processing of nonsymbolic numerical magnitude and number word sequence skills
JF  - Journal of experimental child psychology
N2  - Nonsymbolic numerical magnitude processing skills are assumed to be fundamental to mathematical learning. Recent findings suggest that visual–spatial skills account for associations between children’s performance in visually presented nonsymbolic numerical magnitude comparison tasks and their performance in visually presented arithmetic tasks. The aim of the current study was to examine whether associations between children’s performance in visually presented tasks assessing nonsymbolic numerical magnitude processing skills and their performance in tasks assessing early mathematical skills, which do not involve visual stimulation, may also be mediated by visual–spatial skills. This line of reasoning is based on the assumption that children make use of mental visualization processes when working on tasks assessing early mathematical skills, such as knowledge of the sequence of number words, even when these tasks do not involve visual stimulation. We assessed 4- to 6-year-old children’s performance in a nonsymbolic numerical magnitude comparison task, in tasks concerning knowledge of the sequence of number words, and in a developmental test to assess visual–spatial skills. Children’s nonsymbolic numerical magnitude processing skills were found to be associated with their number word sequence skills. This association was fully mediated by interindividual differences in visual–spatial skills. The effect size of this mediation effect was small. We assume that the ability to construct mental visualizations constitutes the key factor underlying this mediation effect.
KW  - Approximate number system
KW  - Numerical magnitude processing
KW  - Number word sequence skills
KW  - Visual-spatial skills
KW  - Mental visualization
KW  - Mental number line
Y1  - 2018
U6  - https://doi.org/10.1016/j.jecp.2018.09.018
SN  - 0022-0965
SN  - 1096-0457
VL  - 178
SP  - 184
EP  - 197
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Wüstenhagen, Doreen Anja
A1  - Lukas, Phil
A1  - Müller, Christian
A1  - Aubele, Simone A.
A1  - Hildebrandt, Jan-Peter
A1  - Kubick, Stefan
T1  - Cell-free synthesis of the hirudin variant 1 of the blood-sucking leech Hirudo medicinalis
JF  - Scientific reports
N2  - Synthesis and purification of peptide drugs for medical applications is a challenging task. The leech-derived factor hirudin is in clinical use as an alternative to heparin in anticoagulatory therapies. So far, recombinant hirudin is mainly produced in bacterial or yeast expression systems. We describe the successful development and application of an alternative protocol for the synthesis of active hirudin based on a cell-free protein synthesis approach. Three different cell lysates were compared, and the effects of two different signal peptide sequences on the synthesis of mature hirudin were determined. The combination of K562 cell lysates and the endogenous wild-type signal peptide sequence was most effective. Cell-free synthesized hirudin showed a considerably higher anti-thrombin activity compared to recombinant hirudin produced in bacterial cells.
Y1  - 2020
U6  - https://doi.org/10.1038/s41598-020-76715-w
SN  - 2045-2322
VL  - 10
IS  - 1
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Wang, Weijia
A1  - Kaune, Gunar
A1  - Perlich, Jan
A1  - Paradakis, Christine M.
A1  - Bivigou Koumba, Achille Mayelle
A1  - Laschewsky, André
A1  - Schlage, K.
A1  - Röhlsberger, Ralf
A1  - Roth, Stephan V.
A1  - Cubitt, Robert
A1  - Müller-Buschbaum, Peter
T1  - Swelling and switching kinetics of gold coated end-capped poly(N-isopropylacrylamide) thin films
N2  - Thin thermoresponsive hydrogel films of poly(N-isopropylacrylamide) end-capped with n-butyltrithiocarbonate(nbc- PNIPAM) oil si I icon supports with a gold layer on top, causing an asymmetric confinement, are investigated. For two different gold layer thicknesses (nominally 0.4 and 5 rim), the swelling and switching kinetics are probed with in situ neutron reflectivity. With a temperature jump from 23 to 40 degrees C the film is switched from a swollen into a collapsed state. For the thin gold layer this switching is faster as compared to the thick gold layer. The switching is a two-step process of water release and a subsequent structural relaxation. fit swelling and deswelling cycles, aging of the films is probed. After five cycles, the film exhibits enhanced water storage capacity. Grazing-incidence small-angle X-ray scattering (GISAXS) shows that these gold coated nbc-PNIPAM films do not age with respect to the inner structure but slightly roughen at the gold surface. As revealed by atomic force microscopy, the morphology of the gold layer is changed by the water uptake and release.
Y1  - 2010
UR  - http://pubs.acs.org/journal/mamobx
U6  - https://doi.org/10.1021/Ma902637a
SN  - 0024-9297
ER  - 
TY  - JOUR
A1  - Nettels, Daniel
A1  - Müller-Späth, Sonja
A1  - Küster, Frank
A1  - Hofmann, Hagen
A1  - Haenni, Domminik
A1  - Rüegger, Stefan
A1  - Reymond, Luc
A1  - Hoffmann, Armin S.
A1  - Kubelka, Jan
A1  - Heinz, Benjamin
A1  - Gast, Klaus
A1  - Best, Robert B.
A1  - Schuler, Benjamin
T1  - Single-molecule spectroscopy of the temperature-induced collapse of unfolded proteins
N2  - We used single-molecule FRET in combination with other biophysical methods and molecular simulations to investigate the effect of temperature on the dimensions of unfolded proteins. With singlemolecule FRET, this question can be addressed even under nearnative conditions, where most molecules are folded, allowing us to probe a wide range of denaturant concentrations and temperatures. We find a compaction of the unfolded state of a small cold shock protein with increasing temperature in both the presence and the absence of denaturant, with good agreement between the results from single-molecule FRET and dynamic light scattering. Although dissociation of denaturant from the polypeptide chain with increasing temperature accounts for part of the compaction, the results indicate an important role for additional temperaturedependent interactions within the unfolded chain. The observation of a collapse of a similar extent in the extremely hydrophilic, intrinsically disordered protein prothymosin suggests that the hydrophobic effect is not the sole source of the underlying interactions. Circular dichroism spectroscopy and replica exchange molecular dynamics simulations in explicit water show changes in secondary structure content with increasing temperature and suggest a contribution of intramolecular hydrogen bonding to unfolded state collapse.
Y1  - 2009
UR  - http://www.pnas.org/content/106/49/20740.full.pdf+html
SN  - 0027-8424
ER  - 
TY  - JOUR
A1  - Klingstrom, Tomas
A1  - Soldatova, Larissa
A1  - Stevens, Robert
A1  - Roos, T. Erik
A1  - Swertz, Morris A.
A1  - Müller, Kristian M.
A1  - Kalas, Matus
A1  - Lambrix, Patrick
A1  - Taussig, Michael J.
A1  - Litton, Jan-Eric
A1  - Landegren, Ulf
A1  - Bongcam-Rudloff, Erik
T1  - Workshop on laboratory protocol standards for the molecular methods database
JF  - New biotechnology
N2  - Management of data to produce scientific knowledge is a key challenge for biological research in the 21st century. Emerging high-throughput technologies allow life science researchers to produce big data at speeds and in amounts that were unthinkable just a few years ago. This places high demands on all aspects of the workflow: from data capture (including the experimental constraints of the experiment), analysis and preservation, to peer-reviewed publication of results. Failure to recognise the issues at each level can lead to serious conflicts and mistakes; research may then be compromised as a result of the publication of non-coherent protocols, or the misinterpretation of published data. In this report, we present the results from a workshop that was organised to create an ontological data-modelling framework for Laboratory Protocol Standards for the Molecular Methods Database (MolMeth). The workshop provided a set of short- and long-term goals for the MolMeth database, the most important being the decision to use the established EXACT description of biomedical ontologies as a starting point.
Y1  - 2013
U6  - https://doi.org/10.1016/j.nbt.2012.05.019
SN  - 1871-6784
VL  - 30
IS  - 2
SP  - 109
EP  - 113
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jedrusik-Bode, Monika
A1  - Studencka, Maja
A1  - Smolka, Christian
A1  - Baumann, Tobias
A1  - Schmidt, Henning
A1  - Kampf, Jan
A1  - Paap, Franziska
A1  - Martin, Sophie
A1  - Tazi, Jamal
A1  - Müller, Kristian M.
A1  - Krüger, Marcus
A1  - Braun, Thomas
A1  - Bober, Eva
T1  - The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
JF  - Journal of cell science
N2  - SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.
KW  - C. elegans
KW  - G3BP
KW  - SIRT6
KW  - Sirtuins
KW  - Stress
KW  - Stress granules
Y1  - 2013
U6  - https://doi.org/10.1242/jcs.130708
SN  - 0021-9533
SN  - 1477-9137
VL  - 126
IS  - 22
SP  - 5166
EP  - +
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Reimold, Wolf Uwe
A1  - Fischer, Luise
A1  - Müller, Jan
A1  - Kenkmann, Thomas
A1  - Schmitt, Ralf-Thomas
A1  - Altenberger, Uwe
A1  - Kowitz, Astrid
T1  - Impact-generated pseudotachylitic breccia in drill core BH-5 Hattberg, Siljan impact structure, Sweden
JF  - GFF
N2  - Pseudotachylitic breccia (PTB) in the form of cm-wide melt breccia veinlets locally occurs on the exposed central uplift of the 380Ma Siljan impact structure. The host rock to the PTBs is the so-called Jarna granite of quartz monzonitic to syenodioritic composition. The nearly 603m long BH-5 drill core from Hattberg, near the centre of the Siljan central uplift, contains numerous veins and pods of PTB. In particular, two major zones of 60m combined width contain extensive PTB network breccias (30% actual melt breccia component), with individual melt breccia occurrences up to >1m in length. Core logging and petrographic and geochemical analysis of the core have been performed, and the data are interpreted to suggest the following. (1) The impact event caused low to moderate (at essentially <20GPa) shock deformation in the host rock and in clasts of this lithology within the PTB. (2) Macroscopic deformation of the basement mainly comprises fracturing, with only localised cataclasis. (3) No evidence for shock melting (i.e. compression/decompression melting early in the cratering process) could be observed. (4) Optical and scanning electron microscopy showed that dark PTB contains a definite melt component. (5) Shearing has significantly affected this part of the central uplift, but its effects are limited to very short displacements and likely did not result in extensive melting. (6) A frictional heating component upon melt generation can, however, not be excluded, as many PTB samples contain clasts of a mafic (gabbroic) component, although only in one place along the entire core, a 1.2cm-wide section through such material in direct contact to host rock was observed. Consequently, we suggest that, upon uplift in the central part of the impact structure, considerable melt volumes were generated locally, especially in areas that had been affected by extensive cataclasis and where grain size comminution favoured melt formation. Rapid decompression related to central uplift formation is the preferred process for the generation of the PTB melt breccias.
Y1  - 2015
U6  - https://doi.org/10.1080/11035897.2015.1015264
SN  - 1103-5897
SN  - 2000-0863
VL  - 137
IS  - 2
SP  - 141
EP  - 162
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Rössler, Patrick
A1  - Bomhoff, Jana
A1  - Haschke, Josef Ferdinand
A1  - Kersten, Jan
A1  - Müller, Rüdiger
T1  - Selection and impact of press photography
BT  - an empirical study on the basis of photo news factors
JF  - Communications : the European journal of communication research
N2  - The selection of 'good' pictures has increasingly become a crucial factor when transmitting news to the recipients. Every day thousands of events are happening and millions of pictures are taken. By choosing photographs for newspapers and magazines, photographic editorial departments want to attract the recipients' attention, evoke emotions and get them to read their stories. But what exactly is a good picture that meets these expectations? Which criteria are decisive for selecting pictures and what effects of this selection can be measured on the recipients' side?
 This article presents the results of a research project carried out at the University of Erfurt in 2008 and conducted in collaboration with the German weekly magazine stern. It deals with the selection and impact of press photography by introducing the concept 'photo news factors'. Applying the traditional news value theory to pictures, photo news factors are defined as selection criteria that, on the part of the communicator, decide whether the press photos are worth publishing. Furthermore, they are assumed to exert an influence on the intensity of attention that a picture arouses.
KW  - press photography
KW  - news value theory
KW  - photo news factors selectivity
KW  - media effects
Y1  - 2011
U6  - https://doi.org/10.1515/COMM.2011.021
SN  - 0341-2059
VL  - 36
IS  - 4
SP  - 415
EP  - 439
PB  - De Gruyter Mouton
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Skirycz, Aleksandra
A1  - Reichelt, Michael
A1  - Burow, Meike
A1  - Birkemeyer, Claudia Sabine
A1  - Rolcik, Jacub
A1  - Kopka, Joachim
A1  - Zanor, Maria Ines
A1  - Gershenzon, Jonathan
A1  - Strnad, Miroslav
A1  - Szopa, Jan
A1  - Müller-Röber, Bernd
A1  - Witt, Isabell
T1  - DOF transcription factor AtDof1.1 (OBP2) is part of a regulatory network controlling glucosinolate biosynthesis in Arabidopsis
N2  - Glucosinolates are a group of secondary metabolites that function as defense substances against herbivores and micro-organisms in the plant order Capparales. Indole glucosinolates (IGS), derivatives of tryptophan, may also influence plant growth and development. In Arabidopsis thaliana, indole-3-acetaldoxime (IAOx) produced from tryptophan by the activity of two cytochrome P450 enzymes, CYP79B2 and CYP79B3, serves as a precursor for IGS biosynthesis but is also an intermediate in the biosynthetic pathway of indole-3-acetic acid (IAA). Another cytochrome P450 enzyme, CYP83B1, funnels IAOx into IGS. Although there is increasing information about the genes involved in this biochemical pathway, their regulation is not fully understood. OBP2 has recently been identified as a member of the DNA-binding-with-one- finger (DOF) transcription factors, but its function has not been studied in detail so far. Here we report that OBP2 is expressed in the vasculature of all Arabidopsis organs, including leaves, roots, flower stalks and petals. OBP2 expression is induced in response to a generalist herbivore, Spodoptera littoralis, and by treatment with the plant signalling molecule methyl jasmonate, both of which also trigger IGS accumulation. Constitutive and inducible over- expression of OBP2 activates expression of CYP83B1. In addition, auxin concentration is increased in leaves and seedlings of OBP2 over-expression lines relative to wild-type, and plant size is diminished due to a reduction in cell size. RNA interference-mediated OBP2 blockade leads to reduced expression of CYP83B1. Collectively, these data provide evidence that OBP2 is part of a regulatory network that regulates glucosinolate biosynthesis in Arabidopsis
Y1  - 2006
UR  - http://onlinelibrary.wiley.com/doi/10.1111/j.1365-313X.2006.02767.x/full
ER  - 
TY  - JOUR
A1  - Gajdanowicz, Pawel
A1  - Garcia-Mata, Carlos
A1  - Gonzalez, Wendy
A1  - Morales-Navarro, Samuel Elïas
A1  - Sharma, Tripti
A1  - Gonzalez-Nilo, Fernando Danilo
A1  - Gutowicz, Jan
A1  - Müller-Röber, Bernd
A1  - Blatt, Michael R.
A1  - Dreyer, Ingo
T1  - Distinct roles of the last transmembrane domain in controlling Arabidopsis K+ channel activity
N2  - The family of voltage-gated potassium channels in plants presumably evolved from a common ancestor and includes both inward-rectifying (K-in) channels that allow plant cells to accumulate K+ and outward-rectifying (K-out) channels that mediate K+ efflux. Despite their close structural similarities, the activity of Kin channels is largely independent of K+ and depends only on the transmembrane voltage, whereas that of K-out channels responds to the membrane voltage and the prevailing extracellular K+ concentration. Gating of potassium channels is achieved by structural rearrangements within the last transmembrane domain (S6). Here we investigated the functional equivalence of the S6 helices of the Kin channel KAT1 and the K-out channel SKOR by domain-swapping and site-directed mutagenesis. Channel mutants and chimeras were analyzed after expression in Xenopus oocytes. We identified two discrete regions that influence gating differently in both channels, demonstrating a lack of functional complementarity between KAT1 and SKOR. Our findings are supported by molecular models of KAT1 and SKOR in the open and closed states. The role of the S6 segment in gating evolved differently during specialization of the two channel subclasses, posing an obstacle for the transfer of the K+-sensor from K-out to K-in channels.
Y1  - 2009
UR  - http://www3.interscience.wiley.com/cgi-bin/issn?DESCRIPTOR=PRINTISSN&VALUE=0028-646X
U6  - https://doi.org/10.1111/j.1469-8137.2008.02749.x
SN  - 0028-646X
ER  - 
TY  - JOUR
A1  - Brotman, Yariv
A1  - Landau, Udi
A1  - Pnini, Smadar
A1  - Lisec, Jan
A1  - Balazadeh, Salma
A1  - Müller-Röber, Bernd
A1  - Zilberstein, Aviah
A1  - Willmitzer, Lothar
A1  - Chet, Ilan
A1  - Viterbo, Ada
T1  - The LysM Receptor-Like Kinase LysM RLK1 is required to activate defense and abiotic-stress responses induced by overexpression of fungal chitinases in arabidopsis plants
JF  - Molecular plant
N2  - Application of crab shell chitin or pentamer chitin oligosaccharide to Arabidopsis seedlings increased tolerance to salinity in wild-type but not in knockout mutants of the LysM Receptor-Like Kinase1 (CERK1/LysM RLK1) gene, known to play a critical role in signaling defense responses induced by exogenous chitin. Arabidopsis plants overexpressing the endochitinase chit36 and hexoaminidase excy1 genes from the fungus Trichoderma asperelleoides T203 showed increased tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection. Resistant lines, overexpressing fungal chitinases at different levels, were outcrossed to lysm rlk1 mutants. Independent homozygous hybrids lost resistance to biotic and abiotic stresses, despite enhanced chitinase activity. Expression analysis of 270 stress-related genes, including those induced by reactive oxygen species (ROS) and chitin, revealed constant up-regulation (at least twofold) of 10 genes in the chitinase-overexpressing line and an additional 76 salt-induced genes whose expression was not elevated in the lysm rlk1 knockout mutant or the hybrids harboring the mutation. These findings elucidate that chitin-induced signaling mediated by LysM RLK1 receptor is not limited to biotic stress response but also encompasses abiotic-stress signaling and can be conveyed by ectopic expression of chitinases in plants.
KW  - abiotic stress
KW  - chitin-induced signaling
KW  - chitinases
KW  - LysM receptor kinase
KW  - Trichoderma
Y1  - 2012
U6  - https://doi.org/10.1093/mp/sss021
SN  - 1674-2052
VL  - 5
IS  - 5
SP  - 1113
EP  - 1124
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Niebuur, Bart-Jan
A1  - Puchmayr, Jonas
A1  - Herold, Christian
A1  - Kreuzer, Lucas
A1  - Hildebrand, Viet
A1  - Müller-Buschbaum, Peter
A1  - Laschewsky, Andre
A1  - Papadakis, Christine M.
T1  - Polysulfobetaines in aqueous solution and in thin film geometry
JF  - Materials
N2  - Polysulfobetaines in aqueous solution show upper critical solution temperature (UCST) behavior. We investigate here the representative of this class of materials, poly (N,N-dimethyl-N-(3-methacrylamidopropyl) ammonio propane sulfonate) (PSPP), with respect to: (i) the dynamics in aqueous solution above the cloud point as function of NaBr concentration; and (ii) the swelling behavior of thin films in water vapor as function of the initial film thickness. For PSPP solutions with a concentration of 5 wt.%, the temperature dependence of the intensity autocorrelation functions is measured with dynamic light scattering as function of molar mass and NaBr concentration (0-8 mM). We found a scaling of behavior for the scattered intensity and dynamic correlation length. The resulting spinodal temperatures showed a maximum at a certain (small) NaBr concentration, which is similar to the behavior of the cloud points measured previously by turbidimetry. The critical exponent of susceptibility depends on NaBr concentration, with a minimum value where the spinodal temperature is maximum and a trend towards the mean-field value of unity with increasing NaBr concentration. In contrast, the critical exponent of the correlation length does not depend on NaBr concentration and is lower than the value of 0.5 predicted by mean-field theory. For PSPP thin films, the swelling behavior was found to depend on film thickness. A film thickness of about 100 nm turns out to be the optimum thickness needed to obtain fast hydration with H2O.
KW  - polyzwitterions
KW  - polysulfobetaines
KW  - dynamic light scattering
KW  - phase behavior
Y1  - 2018
U6  - https://doi.org/10.3390/ma11050850
SN  - 1996-1944
VL  - 11
IS  - 5
PB  - MDPI
CY  - Basel
ER  - 
TY  - GEN
A1  - Niebuur, Bart-Jan
A1  - Puchmayr, Jonas
A1  - Herold, Christian
A1  - Kreuzer, Lucas
A1  - Hildebrand, Viet
A1  - Müller-Buschbaum, Peter
A1  - Laschewsky, André
A1  - Papadakis, Christine M.
T1  - Polysulfobetaines in aqueous solution and in thin film geometry
T2  - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
N2  - Polysulfobetaines in aqueous solution show upper critical solution temperature (UCST) behavior. We investigate here the representative of this class of materials, poly (N,N-dimethyl-N-(3-methacrylamidopropyl) ammonio propane sulfonate) (PSPP), with respect to: (i) the dynamics in aqueous solution above the cloud point as function of NaBr concentration; and (ii) the swelling behavior of thin films in water vapor as function of the initial film thickness. For PSPP solutions with a concentration of 5 wt.%, the temperature dependence of the intensity autocorrelation functions is measured with dynamic light scattering as function of molar mass and NaBr concentration (0–8 mM). We found a scaling of behavior for the scattered intensity and dynamic correlation length. The resulting spinodal temperatures showed a maximum at a certain (small) NaBr concentration, which is similar to the behavior of the cloud points measured previously by turbidimetry. The critical exponent of susceptibility depends on NaBr concentration, with a minimum value where the spinodal temperature is maximum and a trend towards the mean-field value of unity with increasing NaBr concentration. In contrast, the critical exponent of the correlation length does not depend on NaBr concentration and is lower than the value of 0.5 predicted by mean-field theory. For PSPP thin films, the swelling behavior was found to depend on film thickness. A film thickness of about 100 nm turns out to be the optimum thickness needed to obtain fast hydration with H 2 O.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 713 
KW  - polyzwitterions
KW  - polysulfobetaines
KW  - dynamic light scattering
KW  - phase behavior
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427363
SN  - 1866-8372
IS  - 713
ER  - 
TY  - GEN
A1  - Rössler, Patrick
A1  - Bomhoff, Jana
A1  - Haschke, Josef Ferdinand
A1  - Kersten, Jan
A1  - Müller, Rüdiger
T1  - Selection and impact of press photography
BT  - an empirical study on the basis of photo news factors
T2  - Postprints der Universität Potsdam : Philosophische Reihe
N2  - The selection of ‘good’ pictures has increasingly become a crucial factor when transmitting news to the recipients. Every day thousands of events are happening and millions of pictures are taken. By choosing photographs for newspapers and magazines, photographic editorial departments want to attract the recipients’ attention, evoke emotions and get them to read their stories. But what exactly is a good picture that meets these expectations? Which criteria are decisive for selecting pictures and what effects of this selection can be measured on the recipients’ side? This article presents the results of a research project carried out at the University of Erfurt in 2008 and conducted in collaboration with the German weekly magazine stern. It deals with the selection and impact of press photography by introducing the concept ‘photo news factors’. Applying the traditional news value theory to pictures, photo news factors are defined as selection criteria that, on the part of the communicator, decide whether the press photos are worth publishing. Furthermore, they are assumed to exert an influence on the intensity of attention that a picture arouses.
T3  - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 103 
KW  - press photography
KW  - news value theory
KW  - photo news factors
KW  - selectivity
KW  - media effects
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-93694
SN  - 1866-8380
IS  - 103
ER  - 
TY  - JOUR
A1  - Zhong, Qi
A1  - Wang, Weinan
A1  - Adelsberger, Joseph
A1  - Golosova, Anastasia
A1  - Koumba, Achille M. Bivigou
A1  - Laschewsky, André
A1  - Funari, Sergio S.
A1  - Perlich, Jan
A1  - Roth, Stephan V.
A1  - Papadakis, Christine M.
A1  - Müller-Buschbaum, Peter
T1  - Collapse transition in thin films of poly(methoxydiethylenglycol acrylate)
JF  - Colloid and polymer science : official journal of the Kolloid-Gesellschaft
N2  - The thermal behavior of poly(methoxydiethylenglycol acrylate) (PMDEGA) is studied in thin hydrogel films on solid supports and is compared with the behavior in aqueous solution. The PMDEGA hydrogel film thickness is varied from 2 to 422 nm. Initially, these films are homogenous, as measured with optical microscopy, atomic force microscopy, X-ray reflectivity, and grazing-incidence small-angle X-ray scattering (GISAXS). However, they tend to de-wet when stored under ambient conditions. Along the surface normal, no long-ranged correlations between substrate and film surface are detected with GISAXS, due to the high mobility of the polymer at room temperature. The swelling of the hydrogel films as a function of the water vapor pressure and the temperature are probed for saturated water vapor pressures between 2,380 and 3,170 Pa. While the swelling capability is found to increase with water vapor pressure, swelling in dependence on the temperature revealed a collapse phase transition of a lower critical solution temperature type. The transition temperature decreases from 40.6 A degrees C to 36.6 A degrees C with increasing film thickness, but is independent of the thickness for very thin films below a thickness of 40 nm. The observed transition temperature range compares well with the cloud points observed in dilute (0.1 wt.%) and semi-dilute (5 wt.%) solution which decrease from 45 A degrees C to 39 A degrees C with increasing concentration.
KW  - Hydrogel
KW  - Thin film
KW  - Thermoresponsive
KW  - LCST behavior
KW  - GISAXS
KW  - AFM
Y1  - 2011
U6  - https://doi.org/10.1007/s00396-011-2384-1
SN  - 0303-402X
VL  - 289
IS  - 5-6
SP  - 569
EP  - 581
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Vishnevetskaya, Natalya S.
A1  - Hildebrand, Viet
A1  - Niebuur, Bart-Jan
A1  - Grillo, Isabelle
A1  - Filippov, Sergey K.
A1  - Laschewsky, Andre
A1  - Müller-Buschbaum, Peter
A1  - Papadakis, Christine M.
T1  - Aggregation Behavior of Doubly Thermoresponsive Polysulfobetaine-b-poly(N-isopropylacrylamide) Diblock Copolymers
JF  - Macromolecules : a publication of the American Chemical Society
N2  - A 2-fold thermoresponsive diblock copolymer PSPP430-b-PNIPAM(200) consisting of a zwitterionic polysulfobetaine (PSPP) block and a nonionic poly(N-isopropylacrylamide) (PNIPAM) block is prepared by successive RAFT polymerizations. In aqueous solution, the corresponding homopolymers PSPP and PNIPAM feature both upper and lower critical solution temperature (UCST and LCST) behavior, respectively. The diblock copolymer exhibits thermally induced "schizophrenic" aggregation behavior in aqueous solutions. Moreover, the ion sensitivity of the, cloud point of the zwitterionic PSPP block to both the ionic strength and the nature of the salt offers the possibility to create switchable systems which respond sensitively to changes of the temperature and of the electrolyte type and concentration. The diblock copolymer solutions in D2O are investigated by means of turbidimetry and small-angle neutron scattering (SANS) with respect to the phase behavior and the self-assembled structures in dependence on temperature and electrolyte content. Marked, differences of the aggregation below the UCST-type and above the LCST-type transition are observed. The addition of a small amount of NaBr (0.004 M) does not affect the overall behavior, and only the UCST-type transition and aggregate structures are slightly altered, reflecting the well-known ion sensitivity of the zwitterionic PSPP block.
Y1  - 2016
U6  - https://doi.org/10.1021/acs.macromol.6b01186
SN  - 0024-9297
SN  - 1520-5835
VL  - 49
SP  - 6655
EP  - 6668
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Müller, Eva Nora
A1  - van Schaik, Loes
A1  - Blume, Theresa
A1  - Bronstert, Axel
A1  - Carus, Jana
A1  - Fleckenstein, Jan H.
A1  - Fohrer, Nicola
A1  - Geissler, Katja
A1  - Gerke, Horst H.
A1  - Gräff, Thomas
A1  - Hesse, Cornelia
A1  - Hildebrandt, Anke
A1  - Hölker, Franz
A1  - Hunke, Philip
A1  - Körner, Katrin
A1  - Lewandowski, Jörg
A1  - Lohmann, Dirk
A1  - Meinikmann, Karin
A1  - Schibalski, Anett
A1  - Schmalz, Britta
A1  - Schröder-Esselbach, Boris
A1  - Tietjen, Britta
T1  - Scales, key aspects, feedbacks and challenges of ecohydrological research in Germany
JF  - Hydrologie und Wasserbewirtschaftung
N2  - Ecohydrology analyses the interactions of biotic and abiotic aspects of our ecosystems and landscapes. It is a highly diverse discipline in terms of its thematic and methodical research foci. This article gives an overview of current German ecohydrological research approaches within plant-animal-soil-systems, meso-scale catchments and their river networks, lake systems, coastal areas and tidal rivers. It discusses their relevant spatial and temporal process scales and different types of interactions and feedback dynamics between hydrological and biotic processes and patterns. The following topics are considered key challenges: innovative analysis of the interdisciplinary scale continuum, development of dynamically coupled model systems, integrated monitoring of coupled processes at the interface and transition from basic to applied ecohydrological science to develop sustainable water and land resource management strategies under regional and global change.
KW  - Coastal regions
KW  - drylands
KW  - ecohydrological modelling
KW  - feedback
KW  - hyporheic zone
KW  - meso-scale ecosystems
KW  - plant-animal-soil-system
KW  - river networks
Y1  - 2014
U6  - https://doi.org/10.5675/HyWa_2014,4_2
SN  - 1439-1783
VL  - 58
IS  - 4
SP  - 221
EP  - 240
PB  - Bundesanst. für Gewässerkunde
CY  - Koblenz
ER  - 
TY  - JOUR
A1  - Vishnevetskaya, Natalya S.
A1  - Hildebrand, Viet
A1  - Niebuur, Bart-Jan
A1  - Grillo, Isabelle
A1  - Filippov, Sergey K.
A1  - Laschewsky, Andre
A1  - Müller-Buschbaum, Peter
A1  - Papadakis, Christine M.
T1  - "Schizophrenic" Micelles from Doubly Thermoresponsive Polysulfobetaine-b-poly(N-isopropylmethacrylamide) Diblock Copolymers
JF  - Macromolecules : a publication of the American Chemical Society
Y1  - 2017
U6  - https://doi.org/10.1021/acs.macromol.7b00356
SN  - 0024-9297
SN  - 1520-5835
VL  - 50
SP  - 3985
EP  - 3999
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Vishnevetskaya, Natalya S.
A1  - Hildebrand, Viet
A1  - Dyakonova, Margarita A.
A1  - Niebuur, Bart-Jan
A1  - Kyriakos, Konstantinos
A1  - Raftopoulos, Konstantinos N.
A1  - Di, Zhenyu
A1  - Müller-Buschbaum, Peter
A1  - Laschewsky, Andre
A1  - Papadakis, Christine M.
T1  - Dual orthogonal switching of the "Schizophrenic" self-assembly of diblock copolymers
JF  - Macromolecules : a publication of the American Chemical Society
N2  - Based on diblock copolymers, a pair of "schizophrenic" micellar systems is designed by combining a nonionic and thermoresponsive block with a zwitterionic block, which is thermoresponsive and salt-sensitive. The nonionic block is poly(N-isopropylacrylamide) (PNIPAM) or poly(N-isopropylmethacrylamide) (PNIPMAM) and exhibits a lower critical solution temperature (LCST) behavior in aqueous solution. The zwitterionic block is a polysulfobetaine, i.e., poly(4((3-methacrylamidopropyl)dimethylammonio)butane-1-sulfonate) (PSBP), and has an upper critical solution temperature (UCST) behavior with the clearing point decreasing with increasing salt concentration. The PSBP-b-PNIPAM and PSBP-b-PNIPMAM diblock copolymers are prepared by successive reversible addition-fragmentation chain transfer (RAFT) polymerizations. The PSBP block is chosen such that the clearing point of the homopolymer is significantly higher in pure water than the cloud point of PNIPAM or PNIPMAM. Using turbidimetry, H-1 NMR, and small-angle neutron scattering, we investigate the overall phase behavior as well as the structure and interaction between the micelles and the intermediate phase, both in salt-free D2O and in 0.004 M NaBr in D2O in a wide temperature range. We find that PSBP-b-PNIPAM at 50 g L-1 in salt-free D2O is turbid in the entire temperature range. It forms spherical micelles below the cloud point of PNIPAM and cylindrical micelles above. Similar behavior is observed for PSBP-b-PNIPMAM at 50 g L-1 in salt-free D2O with a slight and smooth increase of the light transmission below the cloud point of PNIPMAM and an abrupt decrease above. Upon addition of 0.004 M NaBr, the UCST-type cloud point of the PSBP-block is notably decreased, and an intermediate regime is encountered below the cloud point of PNIPMAM, where the light transmission is slightly enhanced. In this regime, the polymer solution exhibits behavior typical for polyelectrolyte solutions. Thus, double thermosensitive and salt-sensitive behavior with "schizophrenic" micelle formation is found, and the width of the intermediate regime, where both blocks are hydrophilic, can be tuned by the addition of electrolyte.
Y1  - 2018
U6  - https://doi.org/10.1021/acs.macromol.8b00096
SN  - 0024-9297
SN  - 1520-5835
VL  - 51
IS  - 7
SP  - 2604
EP  - 2614
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - INPR
A1  - Baur, Heiner
A1  - Hoffmann, Jan
A1  - Reichmuth, Anne
A1  - Müller, Steffen
A1  - Mayer, Frank
T1  - Influence of carbon fiber foot orthoses on plantar pressure distribution in cycling
T2  - Sportverletzung, Sportschaden : Grundlagen, Prävention, Rehabilitation
N2  - Background: Several equipment interventions like optimizing seat position or optimizing shoe/insole/pedal interface are suggested to reduce overuse injury in cycling. Data analyzing clinical or biomechanical effects of those interventions is sparse. Foot orthoses out of carbon fiber are one possibility to alter the interface between foot and pedal. The aim of this study was therefore to analyze plantar pressure distribution in carbon fiber foot orthoses in comparison to standard insoles of commercially available cycling shoes. Materials and Methods: 11 pain-free triathletes (Age: 29 +/- 9, 1.77 +/- 0.04 m, 68 5 kg) were tested on a cycle ergometer at 60 and 90 rotations per minute (rpm) at workloads of 200 and 300 Watts. Subjects wore in randomized order a cycling shoe with its standard insole (control condition CO) or the shoe with carbon fiber foot orthoses (Condition CA). Mean peak pressure out of 30 movement cycles were extracted for the total foot and specific foot regions (rear, mid, fore foot (medial, central, lateral) and toe region). Three-factor ANOVAs (factor foot orthoses, rpm, workload) for repeated measures (alpha = 0.05) were used to analyze the main question of a foot orthoses effect on peak in-shoe plantar pressure. Results: Peak pressures in the total foot were in a range of 70-75 kPa for 200 Watts (W) (300 W: 85-110 kPa). The carbon fiber foot orthoses reduced peak pressures by -4,1% compared to the standard insole (p = 0,10). In the foot regions rear(-16,6%, p<0.001), mid (-20,0%, p<0.001) and fore foot (-5.9%, p < 0.03)CA reduced peak pressure compared to CO. In the toe region, peak pressure was higher in CA (+16,2%) compared to CO (p<0,001). The lateral fore foot showed higher peak pressures in CA (+34%) and CO (+59%) compared to medial and central fore foot. Conclusion: Carbon fiber can serve as a suitable material for foot orthoses manufacturing in cycling. Plantar pressures do not increase due to the stiffness of the carbon. Individual customization may have the potential to reduce peak pressure in certain foot areas.
KW  - Carbon
KW  - Cycling
KW  - Foot orthoses
KW  - In-shoe measurement
KW  - Plantar Pressure Distribution
Y1  - 2012
SN  - 0932-0555
VL  - 26
IS  - 1
SP  - 12
EP  - 17
PB  - Thieme
CY  - Stuttgart
ER  -