TY  - JOUR
A1  - Jedrusik-Bode, Monika
A1  - Studencka, Maja
A1  - Smolka, Christian
A1  - Baumann, Tobias
A1  - Schmidt, Henning
A1  - Kampf, Jan
A1  - Paap, Franziska
A1  - Martin, Sophie
A1  - Tazi, Jamal
A1  - Müller, Kristian M.
A1  - Krüger, Marcus
A1  - Braun, Thomas
A1  - Bober, Eva
T1  - The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
JF  - Journal of cell science
N2  - SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.
KW  - C. elegans
KW  - G3BP
KW  - SIRT6
KW  - Sirtuins
KW  - Stress
KW  - Stress granules
Y1  - 2013
U6  - https://doi.org/10.1242/jcs.130708
SN  - 0021-9533
SN  - 1477-9137
VL  - 126
IS  - 22
SP  - 5166
EP  - +
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Mrlina, Jan
A1  - Kämpf, Horst
A1  - Kroner, Corinna
A1  - Mingram, Jens
A1  - Stebich, Martina
A1  - Brauer, Achim
A1  - Geissler, Wolfram H.
A1  - Kallmeyer, Jens
A1  - Matthes, Heidrun
A1  - Seidl, Michal
T1  - Discovery of the first Quaternary maar in the Bohemian Massif, Central Europe, based on combined geophysical and geological surveys
N2  - Based on results of previous investigations of tephra-tuff volcaniclastic deposits and a geophysical survey in the surroundings of the Zelezna hurka Quaternary volcano, West Bohemia, we performed detailed geophysical Surveys using gravimetry, magnetometry and electrical conductivity techniques. Striking anomalies were revealed in a morphological depression near Mytina, West Bohemia, as a strong evidence of the assumed maar-diatreme structure. The sharp isometric gravity low of -2.30 mGal, as well as the corresponding positive magnetic anomaly of 200 nT with a negative rim on its northern side indicate a steeply clipping geological body of low density and containing magnetic rocks/minerals. Magnetic survey also showed pronounced local anomalies outside the depression that can reflect relicts of the tephra rim of the maar. This geophysical evidence was then proven by an exploratory drilling near the centre of the gravity anomaly. Macroscopic on-site evaluation of the core, and more detailed sedimentological, petrochemical, palynological and microbiological laboratory analyses further confirmed the existence of a maar structure filled by 84 m of lake sediments reflecting a Succession of several warm and cold climatic periods. Results Of palynological analyses confirm the presence of a continuous palaeoclimate archive, with at least three successive warmer periods of most probably interstadial character from the upper Quaternary Saalian complex. Therefore. the recovered sediment sequence holds strong potential for in-depth palaeoclimate reconstruction and deep biosphere studies. At the bottom of the Mytina-1 (MY- 1) borehole (84-85.5 M), Country rock debris Was found, containing also volcanic bombs and lapilli. The discovered volcanic Structure is considered to be the first known Quaternary maar-diatreme volcano on the territory of the Bohemian Massif. Because of hidden active magmatic processes in combination with earthquake swarm seismicity ca. 20-30 km north of the Mytina maar, reconstruction of the palaeovolcanological evolution is important for evaluation of hazard potential of the NE and E Part of the Cheb Basin.
Y1  - 2009
UR  - http://www.sciencedirect.com/science/journal/03770273
U6  - https://doi.org/10.1016/j.jvolgeores.2009.01.027
SN  - 0377-0273
ER  -