TY - JOUR
A1 - Tiegs, Scott D.
A1 - Costello, David M.
A1 - Isken, Mark W.
A1 - Woodward, Guy
A1 - McIntyre, Peter B.
A1 - Gessner, Mark O.
A1 - Chauvet, Eric
A1 - Griffiths, Natalie A.
A1 - Flecker, Alex S.
A1 - Acuna, Vicenc
A1 - Albarino, Ricardo
A1 - Allen, Daniel C.
A1 - Alonso, Cecilia
A1 - Andino, Patricio
A1 - Arango, Clay
A1 - Aroviita, Jukka
A1 - Barbosa, Marcus V. M.
A1 - Barmuta, Leon A.
A1 - Baxter, Colden V.
A1 - Bell, Thomas D. C.
A1 - Bellinger, Brent
A1 - Boyero, Luz
A1 - Brown, Lee E.
A1 - Bruder, Andreas
A1 - Bruesewitz, Denise A.
A1 - Burdon, Francis J.
A1 - Callisto, Marcos
A1 - Canhoto, Cristina
A1 - Capps, Krista A.
A1 - Castillo, Maria M.
A1 - Clapcott, Joanne
A1 - Colas, Fanny
A1 - Colon-Gaud, Checo
A1 - Cornut, Julien
A1 - Crespo-Perez, Veronica
A1 - Cross, Wyatt F.
A1 - Culp, Joseph M.
A1 - Danger, Michael
A1 - Dangles, Olivier
A1 - de Eyto, Elvira
A1 - Derry, Alison M.
A1 - Diaz Villanueva, Veronica
A1 - Douglas, Michael M.
A1 - Elosegi, Arturo
A1 - Encalada, Andrea C.
A1 - Entrekin, Sally
A1 - Espinosa, Rodrigo
A1 - Ethaiya, Diana
A1 - Ferreira, Veronica
A1 - Ferriol, Carmen
A1 - Flanagan, Kyla M.
A1 - Fleituch, Tadeusz
A1 - Shah, Jennifer J. Follstad
A1 - Frainer, Andre
A1 - Friberg, Nikolai
A1 - Frost, Paul C.
A1 - Garcia, Erica A.
A1 - Lago, Liliana Garcia
A1 - Garcia Soto, Pavel Ernesto
A1 - Ghate, Sudeep
A1 - Giling, Darren P.
A1 - Gilmer, Alan
A1 - Goncalves, Jose Francisco
A1 - Gonzales, Rosario Karina
A1 - Graca, Manuel A. S.
A1 - Grace, Mike
A1 - Grossart, Hans-Peter
A1 - Guerold, Francois
A1 - Gulis, Vlad
A1 - Hepp, Luiz U.
A1 - Higgins, Scott
A1 - Hishi, Takuo
A1 - Huddart, Joseph
A1 - Hudson, John
A1 - Imberger, Samantha
A1 - Iniguez-Armijos, Carlos
A1 - Iwata, Tomoya
A1 - Janetski, David J.
A1 - Jennings, Eleanor
A1 - Kirkwood, Andrea E.
A1 - Koning, Aaron A.
A1 - Kosten, Sarian
A1 - Kuehn, Kevin A.
A1 - Laudon, Hjalmar
A1 - Leavitt, Peter R.
A1 - Lemes da Silva, Aurea L.
A1 - Leroux, Shawn J.
A1 - Leroy, Carri J.
A1 - Lisi, Peter J.
A1 - MacKenzie, Richard
A1 - Marcarelli, Amy M.
A1 - Masese, Frank O.
A1 - Mckie, Brendan G.
A1 - Oliveira Medeiros, Adriana
A1 - Meissner, Kristian
A1 - Milisa, Marko
A1 - Mishra, Shailendra
A1 - Miyake, Yo
A1 - Moerke, Ashley
A1 - Mombrikotb, Shorok
A1 - Mooney, Rob
A1 - Moulton, Tim
A1 - Muotka, Timo
A1 - Negishi, Junjiro N.
A1 - Neres-Lima, Vinicius
A1 - Nieminen, Mika L.
A1 - Nimptsch, Jorge
A1 - Ondruch, Jakub
A1 - Paavola, Riku
A1 - Pardo, Isabel
A1 - Patrick, Christopher J.
A1 - Peeters, Edwin T. H. M.
A1 - Pozo, Jesus
A1 - Pringle, Catherine
A1 - Prussian, Aaron
A1 - Quenta, Estefania
A1 - Quesada, Antonio
A1 - Reid, Brian
A1 - Richardson, John S.
A1 - Rigosi, Anna
A1 - Rincon, Jose
A1 - Risnoveanu, Geta
A1 - Robinson, Christopher T.
A1 - Rodriguez-Gallego, Lorena
A1 - Royer, Todd V.
A1 - Rusak, James A.
A1 - Santamans, Anna C.
A1 - Selmeczy, Geza B.
A1 - Simiyu, Gelas
A1 - Skuja, Agnija
A1 - Smykla, Jerzy
A1 - Sridhar, Kandikere R.
A1 - Sponseller, Ryan
A1 - Stoler, Aaron
A1 - Swan, Christopher M.
A1 - Szlag, David
A1 - Teixeira-de Mello, Franco
A1 - Tonkin, Jonathan D.
A1 - Uusheimo, Sari
A1 - Veach, Allison M.
A1 - Vilbaste, Sirje
A1 - Vought, Lena B. M.
A1 - Wang, Chiao-Ping
A1 - Webster, Jackson R.
A1 - Wilson, Paul B.
A1 - Woelfl, Stefan
A1 - Xenopoulos, Marguerite A.
A1 - Yates, Adam G.
A1 - Yoshimura, Chihiro
A1 - Yule, Catherine M.
A1 - Zhang, Yixin X.
A1 - Zwart, Jacob A.
T1 - Global patterns and drivers of ecosystem functioning in rivers and riparian zones
JF - Science Advances
N2 - River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
Y1 - 2019
U6 - https://doi.org/10.1126/sciadv.aav0486
SN - 2375-2548
VL - 5
IS - 1
PB - American Assoc. for the Advancement of Science
CY - Washington
ER -
TY - JOUR
A1 - Jannasch, Franziska
A1 - Kröger, Janine
A1 - Agnoli, Claudia
A1 - Barricarte, Aurelio
A1 - Boeing, Heiner
A1 - Cayssials, Valérie
A1 - Colorado-Yohar, Sandra
A1 - Dahm, Christina C.
A1 - Dow, Courtney
A1 - Fagherazzi, Guy
A1 - Franks, Paul W.
A1 - Freisling, Heinz
A1 - Gunter, Marc J.
A1 - Kerrison, Nicola D.
A1 - Key, Timothy J.
A1 - Khaw, Kay-Tee
A1 - Kühn, Tilman
A1 - Kyro, Cecilie
A1 - Mancini, Francesca Romana
A1 - Mokoroa, Olatz
A1 - Nilsson, Peter
A1 - Overvad, Kim
A1 - Palli, Domenico
A1 - Panico, Salvatore
A1 - Quiros Garcia, Jose Ramon
A1 - Rolandsson, Olov
A1 - Sacerdote, Carlotta
A1 - Sanchez, Maria-Jose
A1 - Sahrai, Mohammad Sediq
A1 - Schübel, Ruth
A1 - Sluijs, Ivonne
A1 - Spijkerman, Annemieke M. W.
A1 - Tjonneland, Anne
A1 - Tong, Tammy Y. N.
A1 - Tumino, Rosario
A1 - Riboli, Elio
A1 - Langenberg, Claudia
A1 - Sharp, Stephen J.
A1 - Forouhi, Nita G.
A1 - Schulze, Matthias Bernd
A1 - Wareham, Nicholas J.
T1 - Generalizability of a Diabetes-Associated Country-Specific Exploratory Dietary Pattern Is Feasible Across European Populations
JF - The Journal of Nutrition
N2 - Background: Population-specificity of exploratory dietary patterns limits their generalizability in investigations with type 2 diabetes incidence.
Objective: The aim of this study was to derive country-specific exploratory dietary patterns, investigate their association with type 2 diabetes incidence, and replicate diabetes-associated dietary patterns in other countries.
Methods: Dietary intake data were used, assessed by country-specific questionnaires at baseline of 11,183 incident diabetes cases and 14,694 subcohort members (mean age 52.9 y) from 8 countries, nested within the European Prospective Investigation into Cancer and Nutrition study (mean follow-up time 6.9 y). Exploratory dietary patterns were derived by principal component analysis. HRs for incident type 2 diabetes were calculated by Prentice-weighted Cox proportional hazard regression models. Diabetes-associated dietary patterns were simplified or replicated to be applicable in other countries. A meta-analysis across all countries evaluated the generalizability of the diabetes-association.
Results: Two dietary patterns per country/UK-center, of which overall 3 dietary patterns were diabetes-associated, were identified. A risk-lowering French dietary pattern was not confirmed across other countries: pooled HRFrance per 1 SD: 1.00; 95% CI: 0.90, 1.10. Risk-increasing dietary patterns, derived in Spain and UK-Norfolk, were confirmed, but only the latter statistically significantly: HRSpain: 1.09; 95% CI: 0.97, 1.22 and HRUK-Norfolk: 1.12; 95% CI: 1.04, 1.20. Respectively, this dietary pattern was characterized by relatively high intakes of potatoes, processed meat, vegetable oils, sugar, cake and cookies, and tea. Conclusions: Only few country/center-specific dietary patterns (3 of 18) were statistically significantly associated with diabetes incidence in this multicountry European study population. One pattern, whose association with diabetes was confirmed across other countries, showed overlaps in the food groups potatoes and processed meat with identified diabetes-associated dietary patterns from other studies. The study demonstrates that replication of associations of exploratory patterns with health outcomes is feasible and a necessary step to overcome population-specificity in associations from such analyses.
KW - dietary patterns
KW - principal component analysis
KW - diet-disease association
KW - type 2 diabetes mellitus
KW - replication
KW - meta-analysis
Y1 - 2019
U6 - https://doi.org/10.1093/jn/nxz031
SN - 0022-3166
SN - 1541-6100
VL - 149
IS - 6
SP - 1047
EP - 1055
PB - Oxford Univ. Press
CY - Oxford
ER -
TY - JOUR
A1 - Bronstert, Axel
A1 - de Araujo, Josè Carlos
A1 - Batalla Villanueva, Ramon J.
A1 - Costa, Alexandre Cunha
A1 - Delgado, José Miguel Martins
A1 - Francke, Till
A1 - Förster, Saskia
A1 - Güntner, Andreas
A1 - Lopez-Tarazon, José Andrés
A1 - Mamede, George Leite
A1 - Medeiros, Pedro Henrique Augusto
A1 - Mueller, Eva
A1 - Vericat, Damia
T1 - Process-based modelling of erosion, sediment transport and reservoir siltation in mesoscale semi-arid catchments
JF - Journal of soils and sediments : protection, risk assessment and remediation
N2 - To support scientifically sound water management in dryland environments a modelling system has been developed for the quantitative assessment of water and sediment fluxes in catchments, transport in the river system, and retention in reservoirs. The spatial scale of interest is the mesoscale because this is the scale most relevant for management of water and land resources.
This modelling system comprises process-oriented hydrological components tailored for dryland characteristics coupled with components comprising hillslope erosion, sediment transport and reservoir deposition processes. The spatial discretization is hierarchically designed according to a multi-scale concept to account for particular relevant process scales. The non-linear and partly intermittent run-off generation and sediment dynamics are dealt with by accounting for connectivity phenomena at the intersections of landscape compartments. The modelling system has been developed by means of data from nested research catchments in NE-Spain and in NE-Brazil.
In the semi-arid NE of Brazil sediment retention along the topography is the main process for sediment retention at all scales, i.e. the sediment delivery is transport limited. This kind of deposition retains roughly 50 to 60 % of eroded sediment, maintaining a similar deposition proportion in all spatial scales investigated. On the other hand, the sediment retained in reservoirs is clearly related to the scale, increasing with catchment area. With increasing area, there are more reservoirs, increasing the possibility of deposition. Furthermore, the area increase also promotes an increase in flow volume, favouring the construction of larger reservoirs, which generally overflow less frequently and retain higher sediment fractions. The second example comprises a highly dynamic Mediterranean catchment in NE-Spain with nested sub-catchments and reveals the full dynamics of hydrological, erosion and deposition features. The run-off modelling performed well with only some overestimation during low-flow periods due to the neglect of water losses along the river. The simulated peaks in sediment flux are reproduced well, while low-flow sediment transport is less well captured, due to the disregard of sediment remobilization in the riverbed during low flow.
This combined observation and modelling study deepened the understanding of hydro-sedimentological systems characterized by flashy run-off generation and by erosion and sediment transport pulses through the different landscape compartments. The connectivity between the different landscape compartments plays a very relevant role, regarding both the total mass of water and sediment transport and the transport time through the catchment.
KW - Connectivity
KW - Deposition
KW - Erosion
KW - Modelling
KW - Sediment transfer
KW - Semi-arid
Y1 - 2014
U6 - https://doi.org/10.1007/s11368-014-0994-1
SN - 1439-0108
SN - 1614-7480
VL - 14
IS - 12
SP - 2001
EP - 2018
PB - Springer
CY - Heidelberg
ER -
TY - JOUR
A1 - Mantzouki, Evanthia
A1 - Campbell, James
A1 - van Loon, Emiel
A1 - Visser, Petra
A1 - Konstantinou, Iosif
A1 - Antoniou, Maria
A1 - Giuliani, Gregory
A1 - Machado-Vieira, Danielle
A1 - de Oliveira, Alinne Gurjao
A1 - Maronic, Dubravka Spoljaric
A1 - Stevic, Filip
A1 - Pfeiffer, Tanja Zuna
A1 - Vucelic, Itana Bokan
A1 - Zutinic, Petar
A1 - Udovic, Marija Gligora
A1 - Plenkovic-Moraj, Andelka
A1 - Tsiarta, Nikoletta
A1 - Blaha, Ludek
A1 - Geris, Rodan
A1 - Frankova, Marketa
A1 - Christoffersen, Kirsten Seestern
A1 - Warming, Trine Perlt
A1 - Feldmann, Tonu
A1 - Laas, Alo
A1 - Panksep, Kristel
A1 - Tuvikene, Lea
A1 - Kangro, Kersti
A1 - Haggqvist, Kerstin
A1 - Salmi, Pauliina
A1 - Arvola, Lauri
A1 - Fastner, Jutta
A1 - Straile, Dietmar
A1 - Rothhaupt, Karl-Otto
A1 - Fonvielle, Jeremy Andre
A1 - Grossart, Hans-Peter
A1 - Avagianos, Christos
A1 - Kaloudis, Triantafyllos
A1 - Triantis, Theodoros
A1 - Zervou, Sevasti-Kiriaki
A1 - Hiskia, Anastasia
A1 - Gkelis, Spyros
A1 - Panou, Manthos
A1 - McCarthy, Valerie
A1 - Perello, Victor C.
A1 - Obertegger, Ulrike
A1 - Boscaini, Adriano
A1 - Flaim, Giovanna
A1 - Salmaso, Nico
A1 - Cerasino, Leonardo
A1 - Koreiviene, Judita
A1 - Karosiene, Jurate
A1 - Kasperoviciene, Jurate
A1 - Savadova, Ksenija
A1 - Vitonyte, Irma
A1 - Haande, Sigrid
A1 - Skjelbred, Birger
A1 - Grabowska, Magdalena
A1 - Karpowicz, Maciej
A1 - Chmura, Damian
A1 - Nawrocka, Lidia
A1 - Kobos, Justyna
A1 - Mazur-Marzec, Hanna
A1 - Alcaraz-Parraga, Pablo
A1 - Wilk-Wozniak, Elzbieta
A1 - Krzton, Wojciech
A1 - Walusiak, Edward
A1 - Gagala, Ilona
A1 - Mankiewicz-Boczek, Joana
A1 - Toporowska, Magdalena
A1 - Pawlik-Skowronska, Barbara
A1 - Niedzwiecki, Michal
A1 - Peczula, Wojciech
A1 - Napiorkowska-Krzebietke, Agnieszka
A1 - Dunalska, Julita
A1 - Sienska, Justyna
A1 - Szymanski, Daniel
A1 - Kruk, Marek
A1 - Budzynska, Agnieszka
A1 - Goldyn, Ryszard
A1 - Kozak, Anna
A1 - Rosinska, Joanna
A1 - Szelag-Wasielewska, Elzbieta
A1 - Domek, Piotr
A1 - Jakubowska-Krepska, Natalia
A1 - Kwasizur, Kinga
A1 - Messyasz, Beata
A1 - Pelechata, Aleksandra
A1 - Pelechaty, Mariusz
A1 - Kokocinski, Mikolaj
A1 - Madrecka, Beata
A1 - Kostrzewska-Szlakowska, Iwona
A1 - Frak, Magdalena
A1 - Bankowska-Sobczak, Agnieszka
A1 - Wasilewicz, Michal
A1 - Ochocka, Agnieszka
A1 - Pasztaleniec, Agnieszka
A1 - Jasser, Iwona
A1 - Antao-Geraldes, Ana M.
A1 - Leira, Manel
A1 - Hernandez, Armand
A1 - Vasconcelos, Vitor
A1 - Morais, Joao
A1 - Vale, Micaela
A1 - Raposeiro, Pedro M.
A1 - Goncalves, Vitor
A1 - Aleksovski, Boris
A1 - Krstic, Svetislav
A1 - Nemova, Hana
A1 - Drastichova, Iveta
A1 - Chomova, Lucia
A1 - Remec-Rekar, Spela
A1 - Elersek, Tina
A1 - Delgado-Martin, Jordi
A1 - Garcia, David
A1 - Luis Cereijo, Jose
A1 - Goma, Joan
A1 - Carmen Trapote, Mari
A1 - Vegas-Vilarrubia, Teresa
A1 - Obrador, Biel
A1 - Garcia-Murcia, Ana
A1 - Real, Monserrat
A1 - Romans, Elvira
A1 - Noguero-Ribes, Jordi
A1 - Parreno Duque, David
A1 - Fernandez-Moran, Elisabeth
A1 - Ubeda, Barbara
A1 - Angel Galvez, Jose
A1 - Marce, Rafael
A1 - Catalan, Nuria
A1 - Perez-Martinez, Carmen
A1 - Ramos-Rodriguez, Eloisa
A1 - Cillero-Castro, Carmen
A1 - Moreno-Ostos, Enrique
A1 - Maria Blanco, Jose
A1 - Rodriguez, Valeriano
A1 - Juan Montes-Perez, Jorge
A1 - Palomino, Roberto L.
A1 - Rodriguez-Perez, Estela
A1 - Carballeira, Rafael
A1 - Camacho, Antonio
A1 - Picazo, Antonio
A1 - Rochera, Carlos
A1 - Santamans, Anna C.
A1 - Ferriol, Carmen
A1 - Romo, Susana
A1 - Soria, Juan Miguel
A1 - Hansson, Lars-Anders
A1 - Urrutia-Cordero, Pablo
A1 - Ozen, Arda
A1 - Bravo, Andrea G.
A1 - Buck, Moritz
A1 - Colom-Montero, William
A1 - Mustonen, Kristiina
A1 - Pierson, Don
A1 - Yang, Yang
A1 - Verspagen, Jolanda M. H.
A1 - Domis, Lisette N. de Senerpont
A1 - Seelen, Laura
A1 - Teurlincx, Sven
A1 - Verstijnen, Yvon
A1 - Lurling, Miquel
A1 - Maliaka, Valentini
A1 - Faassen, Elisabeth J.
A1 - Latour, Delphine
A1 - Carey, Cayelan C.
A1 - Paerl, Hans W.
A1 - Torokne, Andrea
A1 - Karan, Tunay
A1 - Demir, Nilsun
A1 - Beklioglu, Meryem
A1 - Filiz, Nur
A1 - Levi, Eti E.
A1 - Iskin, Ugur
A1 - Bezirci, Gizem
A1 - Tavsanoglu, Ulku Nihan
A1 - Celik, Kemal
A1 - Ozhan, Koray
A1 - Karakaya, Nusret
A1 - Kocer, Mehmet Ali Turan
A1 - Yilmaz, Mete
A1 - Maraslioglu, Faruk
A1 - Fakioglu, Ozden
A1 - Soylu, Elif Neyran
A1 - Yagci, Meral Apaydin
A1 - Cinar, Sakir
A1 - Capkin, Kadir
A1 - Yagci, Abdulkadir
A1 - Cesur, Mehmet
A1 - Bilgin, Fuat
A1 - Bulut, Cafer
A1 - Uysal, Rahmi
A1 - Koker, Latife
A1 - Akcaalan, Reyhan
A1 - Albay, Meric
A1 - Alp, Mehmet Tahir
A1 - Ozkan, Korhan
A1 - Sevindik, Tugba Ongun
A1 - Tunca, Hatice
A1 - Onem, Burcin
A1 - Richardson, Jessica
A1 - Edwards, Christine
A1 - Bergkemper, Victoria
A1 - Beirne, Eilish
A1 - Cromie, Hannah
A1 - Ibelings, Bastiaan W.
T1 - Data Descriptor: A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins
JF - Scientific Data
N2 - Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.
KW - Climate-change ecology
KW - Limnology
KW - Water resources
Y1 - 2018
U6 - https://doi.org/10.1038/sdata.2018.226
SN - 2052-4463
VL - 5
PB - Nature Publ. Group
CY - London
ER -
TY - JOUR
A1 - Dengler, Jürgen
A1 - Wagner, Viktoria
A1 - Dembicz, Iwona
A1 - Garcia-Mijangos, Itziar
A1 - Naqinezhad, Alireza
A1 - Boch, Steffen
A1 - Chiarucci, Alessandro
A1 - Conradi, Timo
A1 - Filibeck, Goffredo
A1 - Guarino, Riccardo
A1 - Janisova, Monika
A1 - Steinbauer, Manuel J.
A1 - Acic, Svetlana
A1 - Acosta, Alicia T. R.
A1 - Akasaka, Munemitsu
A1 - Allers, Marc-Andre
A1 - Apostolova, Iva
A1 - Axmanova, Irena
A1 - Bakan, Branko
A1 - Baranova, Alina
A1 - Bardy-Durchhalter, Manfred
A1 - Bartha, Sandor
A1 - Baumann, Esther
A1 - Becker, Thomas
A1 - Becker, Ute
A1 - Belonovskaya, Elena
A1 - Bengtsson, Karin
A1 - Benito Alonso, Jose Luis
A1 - Berastegi, Asun
A1 - Bergamini, Ariel
A1 - Bonini, Ilaria
A1 - Bruun, Hans Henrik
A1 - Budzhak, Vasyl
A1 - Bueno, Alvaro
A1 - Antonio Campos, Juan
A1 - Cancellieri, Laura
A1 - Carboni, Marta
A1 - Chocarro, Cristina
A1 - Conti, Luisa
A1 - Czarniecka-Wiera, Marta
A1 - De Frenne, Pieter
A1 - Deak, Balazs
A1 - Didukh, Yakiv P.
A1 - Diekmann, Martin
A1 - Dolnik, Christian
A1 - Dupre, Cecilia
A1 - Ecker, Klaus
A1 - Ermakov, Nikolai
A1 - Erschbamer, Brigitta
A1 - Escudero, Adrian
A1 - Etayo, Javier
A1 - Fajmonova, Zuzana
A1 - Felde, Vivian A.
A1 - Fernandez Calzado, Maria Rosa
A1 - Finckh, Manfred
A1 - Fotiadis, Georgios
A1 - Fracchiolla, Mariano
A1 - Ganeva, Anna
A1 - Garcia-Magro, Daniel
A1 - Gavilan, Rosario G.
A1 - Germany, Markus
A1 - Giladi, Itamar
A1 - Gillet, Francois
A1 - Giusso del Galdo, Gian Pietro
A1 - Gonzalez, Jose M.
A1 - Grytnes, John-Arvid
A1 - Hajek, Michal
A1 - Hajkova, Petra
A1 - Helm, Aveliina
A1 - Herrera, Mercedes
A1 - Hettenbergerova, Eva
A1 - Hobohm, Carsten
A1 - Huellbusch, Elisabeth M.
A1 - Ingerpuu, Nele
A1 - Jandt, Ute
A1 - Jeltsch, Florian
A1 - Jensen, Kai
A1 - Jentsch, Anke
A1 - Jeschke, Michael
A1 - Jimenez-Alfaro, Borja
A1 - Kacki, Zygmunt
A1 - Kakinuma, Kaoru
A1 - Kapfer, Jutta
A1 - Kavgaci, Ali
A1 - Kelemen, Andras
A1 - Kiehl, Kathrin
A1 - Koyama, Asuka
A1 - Koyanagi, Tomoyo F.
A1 - Kozub, Lukasz
A1 - Kuzemko, Anna
A1 - Kyrkjeeide, Magni Olsen
A1 - Landi, Sara
A1 - Langer, Nancy
A1 - Lastrucci, Lorenzo
A1 - Lazzaro, Lorenzo
A1 - Lelli, Chiara
A1 - Leps, Jan
A1 - Loebel, Swantje
A1 - Luzuriaga, Arantzazu L.
A1 - Maccherini, Simona
A1 - Magnes, Martin
A1 - Malicki, Marek
A1 - Marceno, Corrado
A1 - Mardari, Constantin
A1 - Mauchamp, Leslie
A1 - May, Felix
A1 - Michelsen, Ottar
A1 - Mesa, Joaquin Molero
A1 - Molnar, Zsolt
A1 - Moysiyenko, Ivan Y.
A1 - Nakaga, Yuko K.
A1 - Natcheva, Rayna
A1 - Noroozi, Jalil
A1 - Pakeman, Robin J.
A1 - Palpurina, Salza
A1 - Partel, Meelis
A1 - Paetsch, Ricarda
A1 - Pauli, Harald
A1 - Pedashenko, Hristo
A1 - Peet, Robert K.
A1 - Pielech, Remigiusz
A1 - Pipenbaher, Natasa
A1 - Pirini, Chrisoula
A1 - Pleskova, Zuzana
A1 - Polyakova, Mariya A.
A1 - Prentice, Honor C.
A1 - Reinecke, Jennifer
A1 - Reitalu, Triin
A1 - Pilar Rodriguez-Rojo, Maria
A1 - Rolecek, Jan
A1 - Ronkin, Vladimir
A1 - Rosati, Leonardo
A1 - Rosen, Ejvind
A1 - Ruprecht, Eszter
A1 - Rusina, Solvita
A1 - Sabovljevic, Marko
A1 - Maria Sanchez, Ana
A1 - Savchenko, Galina
A1 - Schuhmacher, Oliver
A1 - Skornik, Sonja
A1 - Sperandii, Marta Gaia
A1 - Staniaszek-Kik, Monika
A1 - Stevanovic-Dajic, Zora
A1 - Stock, Marin
A1 - Suchrow, Sigrid
A1 - Sutcliffe, Laura M. E.
A1 - Swacha, Grzegorz
A1 - Sykes, Martin
A1 - Szabo, Anna
A1 - Talebi, Amir
A1 - Tanase, Catalin
A1 - Terzi, Massimo
A1 - Tolgyesi, Csaba
A1 - Torca, Marta
A1 - Torok, Peter
A1 - Tothmeresz, Bela
A1 - Tsarevskaya, Nadezda
A1 - Tsiripidis, Ioannis
A1 - Tzonev, Rossen
A1 - Ushimaru, Atushi
A1 - Valko, Orsolya
A1 - van der Maarel, Eddy
A1 - Vanneste, Thomas
A1 - Vashenyak, Iuliia
A1 - Vassilev, Kiril
A1 - Viciani, Daniele
A1 - Villar, Luis
A1 - Virtanen, Risto
A1 - Kosic, Ivana Vitasovic
A1 - Wang, Yun
A1 - Weiser, Frank
A1 - Went, Julia
A1 - Wesche, Karsten
A1 - White, Hannah
A1 - Winkler, Manuela
A1 - Zaniewski, Piotr T.
A1 - Zhang, Hui
A1 - Ziv, Yaron
A1 - Znamenskiy, Sergey
A1 - Biurrun, Idoia
T1 - GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands
JF - Phytocoenologia
N2 - GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.
KW - biodiversity
KW - European Vegetation Archive (EVA)
KW - Eurasian Dry Grassland Group (EDGG)
KW - grassland vegetation
KW - GrassPlot
KW - macroecology
KW - multi-taxon
KW - nested plot
KW - scale-dependence
KW - species-area relationship (SAR)
KW - sPlot
KW - vegetation-plot database
Y1 - 2018
U6 - https://doi.org/10.1127/phyto/2018/0267
SN - 0340-269X
VL - 48
IS - 3
SP - 331
EP - 347
PB - Cramer
CY - Stuttgart
ER -
TY - JOUR
A1 - Botteri, Edoardo
A1 - Peveri, Giulia
A1 - Berstad, Paula
A1 - Bagnardi, Vincenzo
A1 - Chen, Sairah L. F.
A1 - Sandanger, Torkjel M.
A1 - Hoff, Geir
A1 - Dahm, Christina C.
A1 - Antoniussen, Christian S.
A1 - Tjonneland, Anne
A1 - Eriksen, Anne Kirstine
A1 - Skeie, Guri
A1 - Perez-Cornago, Aurora
A1 - Huerta, Jose Maria
A1 - Jakszyn, Paula
A1 - Harlid, Sophia
A1 - Sundstroem, Bjoern
A1 - Barricarte, Aurelio
A1 - Monninkhof, Evelyn M.
A1 - Derksen, Jeroen W. G.
A1 - Schulze, Matthias Bernd
A1 - Bueno-de-Mesquita, Bas
A1 - Sanchez, Maria-Jose
A1 - Cross, Amanda J.
A1 - Tsilidis, Konstantinos K.
A1 - De Magistris, Maria Santucci
A1 - Kaaks, Rudolf
A1 - Katzke, Verena
A1 - Rothwell, Joseph A.
A1 - Laouali, Nasser
A1 - Severi, Gianluca
A1 - Amiano, Pilar
A1 - Contiero, Paolo
A1 - Sacerdote, Carlotta
A1 - Goldberg, Marcel
A1 - Touvier, Mathilde
A1 - Freisling, Heinz
A1 - Viallon, Vivian
A1 - Weiderpass, Elisabete
A1 - Riboli, Elio
A1 - Gunter, Marc J.
A1 - Jenab, Mazda
A1 - Ferrari, Pietro
T1 - Changes in lifestyle and risk of colorectal cancer in the European prospective investigation into cancer and nutrition
JF - The American journal of gastroenterology : AJG
N2 - INTRODUCTION:
We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort.
METHODS:
We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI).
RESULTS:
Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI <= 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile.
DISCUSSION:
Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.
Y1 - 2022
U6 - https://doi.org/10.14309/ajg.0000000000002065
SN - 0002-9270
SN - 1572-0241
VL - 118
IS - 4
SP - 702
EP - 711
PB - Lippincott Williams & Wilkins
CY - Philadelphia
ER -
TY - JOUR
A1 - Ahnen, M. L.
A1 - Ansoldi, S.
A1 - Antonelli, L. A.
A1 - Arcaro, C.
A1 - Babic, A.
A1 - Banerjee, B.
A1 - Bangale, P.
A1 - Barres de Almeida, U.
A1 - Barrio, J. A.
A1 - Gonzalez, J. Becerra
A1 - Bednarek, W.
A1 - Bernardini, E.
A1 - Berti, A.
A1 - Bhattacharyya, W.
A1 - Blanch, O.
A1 - Bonnoli, G.
A1 - Carosi, R.
A1 - Carosi, A.
A1 - Chatterjee, A.
A1 - Colak, S. M.
A1 - Colin, P.
A1 - Colombo, E.
A1 - Contreras, J. L.
A1 - Cortina, J.
A1 - Covino, S.
A1 - Cumani, P.
A1 - Da Vela, P.
A1 - Dazzi, F.
A1 - De Angelis, A.
A1 - De Lotto, B.
A1 - Delfino, M.
A1 - Delgado, Jose Miguel Martins
A1 - Di Pierro, F.
A1 - Doert, M.
A1 - Dominguez, A.
A1 - Prester, D. Dominis
A1 - Doro, M.
A1 - Glawion, D. Eisenacher
A1 - Engelkemeier, M.
A1 - Ramazani, V. Fallah
A1 - Fernandez-Barral, A.
A1 - Fidalgo, D.
A1 - Fonseca, M. V.
A1 - Font, L.
A1 - Fruck, C.
A1 - Galindo, D.
A1 - Lopez, R. J. Garcia
A1 - Garczarczyk, M.
A1 - Gaug, M.
A1 - Giammaria, P.
A1 - Godinovic, N.
A1 - Gora, D.
A1 - Guberman, D.
A1 - Hadasch, D.
A1 - Hahn, A.
A1 - Hassan, T.
A1 - Hayashida, M.
A1 - Herrera, J.
A1 - Hose, J.
A1 - Hrupec, D.
A1 - Ishio, K.
A1 - Konno, Y.
A1 - Kubo, H.
A1 - Kushida, J.
A1 - Kuvezdic, D.
A1 - Lelas, D.
A1 - Lindfors, E.
A1 - Lombardi, S.
A1 - Longo, F.
A1 - Lopez, M.
A1 - Maggio, C.
A1 - Majumdar, P.
A1 - Makariev, M.
A1 - Maneva, G.
A1 - Manganaro, M.
A1 - Maraschi, L.
A1 - Mariotti, M.
A1 - Martinez, M.
A1 - Mazin, D.
A1 - Menzel, U.
A1 - Minev, M.
A1 - Miranda, J. M.
A1 - Mirzoyan, R.
A1 - Moralejo, A.
A1 - Moreno, V.
A1 - Moretti, E.
A1 - Nagayoshi, T.
A1 - Neustroev, V.
A1 - Niedzwiecki, A.
A1 - Nievas Rosillo, M.
A1 - Nigro, C.
A1 - Nilsson, K.
A1 - Ninci, D.
A1 - Nishijima, K.
A1 - Noda, K.
A1 - Nogues, L.
A1 - Paiano, S.
A1 - Palacio, J.
A1 - Paneque, D.
A1 - Paoletti, R.
A1 - Paredes, J. M.
A1 - Pedaletti, G.
A1 - Peresano, M.
A1 - Perri, L.
A1 - Persic, M.
A1 - Moroni, P. G. Prada
A1 - Prandini, E.
A1 - Puljak, I.
A1 - Garcia, J. R.
A1 - Reichardt, I.
A1 - Ribo, M.
A1 - Rico, J.
A1 - Righi, C.
A1 - Rugliancich, A.
A1 - Saito, T.
A1 - Satalecka, K.
A1 - Schroeder, S.
A1 - Schweizer, T.
A1 - Shore, S. N.
A1 - Sitarek, J.
A1 - Snidaric, I.
A1 - Sobczynska, D.
A1 - Stamerra, A.
A1 - Strzys, M.
A1 - Suric, T.
A1 - Takalo, L.
A1 - Tavecchio, F.
A1 - Temnikov, P.
A1 - Terzic, T.
A1 - Teshima, M.
A1 - Torres-Alba, N.
A1 - Treves, A.
A1 - Tsujimoto, S.
A1 - Vanzo, G.
A1 - Vazquez Acosta, M.
A1 - Vovk, I.
A1 - Ward, J. E.
A1 - Will, M.
A1 - Zaric, D.
A1 - Arbet-Engels, A.
A1 - Baack, D.
A1 - Balbo, M.
A1 - Biland, A.
A1 - Blank, M.
A1 - Bretz, T.
A1 - Bruegge, K.
A1 - Bulinski, M.
A1 - Buss, J.
A1 - Dmytriiev, A.
A1 - Dorner, D.
A1 - Einecke, S.
A1 - Elsaesser, D.
A1 - Herbst, T.
A1 - Hildebrand, D.
A1 - Kortmann, L.
A1 - Linhoff, L.
A1 - Mahlke, M.
A1 - Mannheim, K.
A1 - Mueller, S. A.
A1 - Neise, D.
A1 - Neronov, A.
A1 - Noethe, M.
A1 - Oberkirch, J.
A1 - Paravac, A.
A1 - Rhode, W.
A1 - Schleicher, B.
A1 - Schulz, F.
A1 - Sedlaczek, K.
A1 - Shukla, A.
A1 - Sliusar, V.
A1 - Walter, R.
A1 - Archer, A.
A1 - Benbow, W.
A1 - Bird, R.
A1 - Brose, Robert
A1 - Buckley, J. H.
A1 - Bugaev, V.
A1 - Christiansen, J. L.
A1 - Cui, W.
A1 - Daniel, M. K.
A1 - Falcone, A.
A1 - Feng, Q.
A1 - Finley, J. P.
A1 - Gillanders, G. H.
A1 - Gueta, O.
A1 - Hanna, D.
A1 - Hervet, O.
A1 - Holder, J.
A1 - Hughes, G.
A1 - Huetten, M.
A1 - Humensky, T. B.
A1 - Johnson, C. A.
A1 - Kaaret, P.
A1 - Kar, P.
A1 - Kelley-Hoskins, N.
A1 - Kertzman, M.
A1 - Kieda, D.
A1 - Krause, M.
A1 - Krennrich, F.
A1 - Kumar, S.
A1 - Lang, M. J.
A1 - Lin, T. T. Y.
A1 - Maier, G.
A1 - McArthur, S.
A1 - Moriarty, P.
A1 - Mukherjee, R.
A1 - Ong, R. A.
A1 - Otte, A. N.
A1 - Park, N.
A1 - Petrashyk, A.
A1 - Pichel, A.
A1 - Pohl, Martin
A1 - Quinn, J.
A1 - Ragan, K.
A1 - Reynolds, P. T.
A1 - Richards, G. T.
A1 - Roache, E.
A1 - Rovero, A. C.
A1 - Rulten, C.
A1 - Sadeh, I.
A1 - Santander, M.
A1 - Sembroski, G. H.
A1 - Shahinyan, K.
A1 - Sushch, Iurii
A1 - Tyler, J.
A1 - Wakely, S. P.
A1 - Weinstein, A.
A1 - Wells, R. M.
A1 - Wilcox, P.
A1 - Wilhel, A.
A1 - Williams, D. A.
A1 - Williamson, T. J.
A1 - Zitzer, B.
A1 - Perri, M.
A1 - Verrecchia, F.
A1 - Leto, C.
A1 - Villata, M.
A1 - Raiteri, C. M.
A1 - Jorstad, S. G.
A1 - Larionov, V. M.
A1 - Blinov, D. A.
A1 - Grishina, T. S.
A1 - Kopatskaya, E. N.
A1 - Larionova, E. G.
A1 - Nikiforova, A. A.
A1 - Morozova, D. A.
A1 - Troitskaya, Yu. V.
A1 - Troitsky, I. S.
A1 - Kurtanidze, O. M.
A1 - Nikolashvili, M. G.
A1 - Kurtanidze, S. O.
A1 - Kimeridze, G. N.
A1 - Chigladze, R. A.
A1 - Strigachev, A.
A1 - Sadun, A. C.
T1 - Extreme HBL behavior of Markarian 501 during 2012
JF - Astronomy and astrophysics : an international weekly journal / European Southern Observatory (ESO)
N2 - Aims. We aim to characterize the multiwavelength emission from Markarian 501 (Mrk 501), quantify the energy-dependent variability, study the potential multiband correlations, and describe the temporal evolution of the broadband emission within leptonic theoretical scenarios. Methods. We organized a multiwavelength campaign to take place between March and July of 2012. Excellent temporal coverage was obtained with more than 25 instruments, including the MAGIC, FACT and VERITAS Cherenkov telescopes, the instruments on board the Swift and Fermi spacecraft, and the telescopes operated by the GASP-WEBT collaboration. Results. Mrk 501 showed a very high energy (VHE) gamma-ray flux above 0.2 TeV of similar to 0.5 times the Crab Nebula flux (CU) for most of the campaign. The highest activity occurred on 2012 June 9, when the VHE flux was similar to 3 CU, and the peak of the high-energy spectral component was found to be at similar to 2 TeV. Both the X-ray and VHE gamma-ray spectral slopes were measured to be extremely hard, with spectral indices <2 during most of the observing campaign, regardless of the X-ray and VHE flux. This study reports the hardest Mrk 501 VHE spectra measured to date. The fractional variability was found to increase with energy, with the highest variability occurring at VHE. Using the complete data set, we found correlation between the X-ray and VHE bands; however, if the June 9 flare is excluded, the correlation disappears (significance <3 sigma) despite the existence of substantial variability in the X-ray and VHE bands throughout the campaign. Conclusions. The unprecedentedly hard X-ray and VHE spectra measured imply that their low- and high-energy components peaked above 5 keV and 0.5 TeV, respectively, during a large fraction of the observing campaign, and hence that Mrk 501 behaved like an extreme high-frequency-peaked blazar (EHBL) throughout the 2012 observing season. This suggests that being an EHBL may not be a permanent characteristic of a blazar, but rather a state which may change over time. The data set acquired shows that the broadband spectral energy distribution (SED) of Mrk 501, and its transient evolution, is very complex, requiring, within the framework of synchrotron self-Compton (SSC) models, various emission regions for a satisfactory description. Nevertheless the one-zone SSC scenario can successfully describe the segments of the SED where most energy is emitted, with a significant correlation between the electron energy density and the VHE gamma-ray activity, suggesting that most of the variability may be explained by the injection of high-energy electrons. The one-zone SSC scenario used reproduces the behavior seen between the measured X-ray and VHE gamma-ray fluxes, and predicts that the correlation becomes stronger with increasing energy of the X-rays.
KW - astroparticle physics
KW - acceleration of particles
KW - radiation mechanisms: non-thermal
KW - BL Lacertae objects: general
KW - BL Lacertae objects: individual: Mrk501
Y1 - 2018
U6 - https://doi.org/10.1051/0004-6361/201833704
SN - 1432-0746
VL - 620
PB - EDP Sciences
CY - Les Ulis
ER -
TY - JOUR
A1 - De Angelis, A.
A1 - Tatischeff, V.
A1 - Grenier, I. A.
A1 - McEnery, J.
A1 - Mallamaci, Manuela
A1 - Tavani, M.
A1 - Oberlack, U.
A1 - Hanlon, L.
A1 - Walter, R.
A1 - Argan, A.
A1 - Von Ballmoos, P.
A1 - Bulgarelli, A.
A1 - Bykov, A.
A1 - Hernanz, M.
A1 - Kanbach, G.
A1 - Kuvvetli, I.
A1 - Pearce, M.
A1 - Zdziarski, A.
A1 - Conrad, J.
A1 - Ghisellini, G.
A1 - Harding, A.
A1 - Isern, J.
A1 - Leising, M.
A1 - Longo, F.
A1 - Madejski, G.
A1 - Martinez, M.
A1 - Mazziotta, Mario Nicola
A1 - Paredes, J. M.
A1 - Pohl, Martin
A1 - Rando, R.
A1 - Razzano, M.
A1 - Aboudan, A.
A1 - Ackermann, M.
A1 - Addazi, A.
A1 - Ajello, M.
A1 - Albertus, C.
A1 - Alvarez, J. M.
A1 - Ambrosi, G.
A1 - Anton, S.
A1 - Antonelli, L. A.
A1 - Babic, A.
A1 - Baibussinov, B.
A1 - Balbom, M.
A1 - Baldini, L.
A1 - Balman, S.
A1 - Bambi, C.
A1 - Barres de Almeida, U.
A1 - Barrio, J. A.
A1 - Bartels, R.
A1 - Bastieri, D.
A1 - Bednarek, W.
A1 - Bernard, D.
A1 - Bernardini, E.
A1 - Bernasconi, T.
A1 - Bertucci, B.
A1 - Biland, A.
A1 - Bissaldi, E.
A1 - Boettcher, M.
A1 - Bonvicini, V.
A1 - Bosch-Ramon, V.
A1 - Bottacini, E.
A1 - Bozhilov, V.
A1 - Bretz, T.
A1 - Branchesi, M.
A1 - Brdar, V.
A1 - Bringmann, T.
A1 - Brogna, A.
A1 - Jorgensen, C. Budtz
A1 - Busetto, G.
A1 - Buson, S.
A1 - Busso, M.
A1 - Caccianiga, A.
A1 - Camera, S.
A1 - Campana, R.
A1 - Caraveo, P.
A1 - Cardillo, M.
A1 - Carlson, P.
A1 - Celestin, S.
A1 - Cermeno, M.
A1 - Chen, A.
A1 - Cheung, C. C.
A1 - Churazov, E.
A1 - Ciprini, S.
A1 - Coc, A.
A1 - Colafrancesco, S.
A1 - Coleiro, A.
A1 - Collmar, W.
A1 - Coppi, P.
A1 - Curado da Silva, R.
A1 - Cutini, S.
A1 - De Lotto, B.
A1 - de Martino, D.
A1 - De Rosa, A.
A1 - Del Santo, M.
A1 - Delgado, L.
A1 - Diehl, R.
A1 - Dietrich, S.
A1 - Dolgov, A. D.
A1 - Dominguez, A.
A1 - Prester, D. Dominis
A1 - Donnarumma, I.
A1 - Dorner, D.
A1 - Doro, M.
A1 - Dutra, M.
A1 - Elsaesser, D.
A1 - Fabrizio, M.
A1 - Fernandez-Barral, A.
A1 - Fioretti, V.
A1 - Foffano, L.
A1 - Formato, V.
A1 - Fornengo, N.
A1 - Foschini, L.
A1 - Franceschini, A.
A1 - Franckowiak, A.
A1 - Funk, S.
A1 - Fuschino, F.
A1 - Gaggero, D.
A1 - Galanti, G.
A1 - Gargano, F.
A1 - Gasparrini, D.
A1 - Gehrz, R.
A1 - Giammaria, P.
A1 - Giglietto, N.
A1 - Giommi, P.
A1 - Giordano, F.
A1 - Giroletti, M.
A1 - Ghirlanda, G.
A1 - Godinovic, N.
A1 - Gouiffes, C.
A1 - Grove, J. E.
A1 - Hamadache, C.
A1 - Hartmann, D. H.
A1 - Hayashida, M.
A1 - Hryczuk, A.
A1 - Jean, P.
A1 - Johnson, T.
A1 - Jose, J.
A1 - Kaufmann, S.
A1 - Khelifi, B.
A1 - Kiener, J.
A1 - Knodlseder, J.
A1 - Kolem, M.
A1 - Kopp, J.
A1 - Kozhuharov, V.
A1 - Labanti, C.
A1 - Lalkovski, S.
A1 - Laurent, P.
A1 - Limousin, O.
A1 - Linares, M.
A1 - Lindfors, E.
A1 - Lindner, M.
A1 - Liu, J.
A1 - Lombardi, S.
A1 - Loparco, F.
A1 - Lopez-Coto, R.
A1 - Lopez Moya, M.
A1 - Lott, B.
A1 - Lubrano, P.
A1 - Malyshev, D.
A1 - Mankuzhiyil, N.
A1 - Mannheim, K.
A1 - Marcha, M. J.
A1 - Marciano, A.
A1 - Marcote, B.
A1 - Mariotti, M.
A1 - Marisaldi, M.
A1 - McBreen, S.
A1 - Mereghetti, S.
A1 - Merle, A.
A1 - Mignani, R.
A1 - Minervini, G.
A1 - Moiseev, A.
A1 - Morselli, A.
A1 - Moura, F.
A1 - Nakazawa, K.
A1 - Nava, L.
A1 - Nieto, D.
A1 - Orienti, M.
A1 - Orio, M.
A1 - Orlando, E.
A1 - Orleanski, P.
A1 - Paiano, S.
A1 - Paoletti, R.
A1 - Papitto, A.
A1 - Pasquato, M.
A1 - Patricelli, B.
A1 - Perez-Garcia, M. A.
A1 - Persic, M.
A1 - Piano, G.
A1 - Pichel, A.
A1 - Pimenta, M.
A1 - Pittori, C.
A1 - Porter, T.
A1 - Poutanen, J.
A1 - Prandini, E.
A1 - Prantzos, N.
A1 - Produit, N.
A1 - Profumo, S.
A1 - Queiroz, F. S.
A1 - Raino, S.
A1 - Raklev, A.
A1 - Regis, M.
A1 - Reichardt, I.
A1 - Rephaeli, Y.
A1 - Rico, J.
A1 - Rodejohann, W.
A1 - Fernandez, G. Rodriguez
A1 - Roncadelli, M.
A1 - Roso, L.
A1 - Rovero, A.
A1 - Ruffini, R.
A1 - Sala, G.
A1 - Sanchez-Conde, M. A.
A1 - Santangelo, Andrea
A1 - Parkinson, P. Saz
A1 - Sbarrato, T.
A1 - Shearer, A.
A1 - Shellard, R.
A1 - Short, K.
A1 - Siegert, T.
A1 - Siqueira, C.
A1 - Spinelli, P.
A1 - Stamerra, A.
A1 - Starrfield, S.
A1 - Strong, A.
A1 - Strumke, I.
A1 - Tavecchio, F.
A1 - Taverna, R.
A1 - Terzic, T.
A1 - Thompson, D. J.
A1 - Tibolla, O.
A1 - Torres, D. F.
A1 - Turolla, R.
A1 - Ulyanov, A.
A1 - Ursi, A.
A1 - Vacchi, A.
A1 - Van den Abeele, J.
A1 - Vankova-Kirilovai, G.
A1 - Venter, C.
A1 - Verrecchia, F.
A1 - Vincent, P.
A1 - Wang, X.
A1 - Weniger, C.
A1 - Wu, X.
A1 - Zaharijas, G.
A1 - Zampieri, L.
A1 - Zane, S.
A1 - Zimmer, S.
A1 - Zoglauer, A.
T1 - Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics
JF - Journal of High Energy Astrophysics
Y1 - 2018
U6 - https://doi.org/10.1016/j.jheap.2018.07.001
SN - 2214-4048
SN - 2214-4056
VL - 19
SP - 1
EP - 106
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Pena-Angulo, D.
A1 - Nadal-Romero, E.
A1 - Gonzalez-Hidalgo, J. C.
A1 - Albaladejo, J.
A1 - Andreu, V
A1 - Bagarello, V
A1 - Barhi, H.
A1 - Batalla, R. J.
A1 - Bernal, S.
A1 - Bienes, R.
A1 - Campo, J.
A1 - Campo-Bescos, M. A.
A1 - Canatario-Duarte, A.
A1 - Canton, Y.
A1 - Casali, J.
A1 - Castillo, V
A1 - Cerda, Artemi
A1 - Cheggour, A.
A1 - Cid, Patricio
A1 - Cortesi, N.
A1 - Desir, G.
A1 - Diaz-Pereira, E.
A1 - Espigares, T.
A1 - Estrany, Joan
A1 - Fernandez-Raga, M.
A1 - Ferreira, Carla S. S.
A1 - Ferro, Vito
A1 - Gallart, Francesc
A1 - Gimenez, R.
A1 - Gimeno, E.
A1 - Gomez, J. A.
A1 - Gomez-Gutierrez, A.
A1 - Gomez-Macpherson, H.
A1 - Gonzalez-Pelayo, O.
A1 - Hueso-Gonzalez, P.
A1 - Kairis, O.
A1 - Karatzas, G. P.
A1 - Klotz, S.
A1 - Kosmas, C.
A1 - Lana-Renault, Noemi
A1 - Lasanta, T.
A1 - Latron, J.
A1 - Lazaro, R.
A1 - Le Bissonnais, Y.
A1 - Le Bouteiller, C.
A1 - Licciardello, F.
A1 - Lopez-Tarazon, José Andrés
A1 - Lucia, A.
A1 - Marin, C.
A1 - Marques, M. J.
A1 - Martinez-Fernandez, J.
A1 - Martinez-Mena, M.
A1 - Martinez-Murillo, J. F.
A1 - Mateos, L.
A1 - Mathys, N.
A1 - Merino-Martin, L.
A1 - Moreno-de las Heras, M.
A1 - Moustakas, N.
A1 - Nicolau, J. M.
A1 - Novara, A.
A1 - Pampalone, V
A1 - Raclot, D.
A1 - Rodriguez-Blanco, M. L.
A1 - Rodrigo-Comino, Jesús
A1 - Romero-Diaz, A.
A1 - Roose, E.
A1 - Rubio, J. L.
A1 - Ruiz-Sinoga, J. D.
A1 - Schnabel, S.
A1 - Senciales-Gonzalez, J. M.
A1 - Simonneaux, V
A1 - Sole-Benet, A.
A1 - Taguas, E.
A1 - Taboada-Castro, M. M.
A1 - Taboada-Castro, M. T.
A1 - Todisco, Francesca
A1 - Ubeda, X.
A1 - Varouchakis, E. A.
A1 - Vericat, Damia
A1 - Wittenberg, L.
A1 - Zabaleta, A.
A1 - Zorn, M.
T1 - Spatial variability of the relationships of runoff and sediment yield with weather types throughout the Mediterranean basin
JF - Journal of hydrology
N2 - Soil degradation by water is a serious environmental problem worldwide, with specific climatic factors being the major causes. We investigated the relationships between synoptic atmospheric patterns (i.e. weather types, WTs) and runoff, erosion and sediment yield throughout the Mediterranean basin by analyzing a large database of natural rainfall events at 68 research sites in 9 countries. Principal Component Analysis (PCA) was used to identify spatial relationships of the different WTs including three hydro-sedimentary variables: rainfall, runoff, and sediment yield (SY, used to refer to both soil erosion measured at plot scale and sediment yield registered at catchment scale). The results indicated 4 spatial classes of rainfall and runoff: (a) northern sites dependent on North (N) and North West (NW) flows; (b) eastern sites dependent on E and NE flows; (c) southern sites dependent on S and SE flows; and, finally, (d) western sites dependent on W and SW flows. Conversely, three spatial classes are identified for SY characterized by: (a) N and NE flows in northern sites (b) E flows in eastern sites, and (c) W and SW flows in western sites. Most of the rainfall, runoff and SY occurred during a small number of daily events, and just a few WTs accounted for large percentages of the total. Our results confirm that characterization by WT improves understanding of the general conditions under which runoff and SY occur, and provides useful information for understanding the spatial variability of runoff, and SY throughout the Mediterranean basin. The approach used here could be useful to aid of the design of regional water management and soil conservation measures.
KW - Synoptic weather types
KW - Erosion
KW - Sediment yield
KW - Runoff
KW - Mediterranean basin
Y1 - 2019
U6 - https://doi.org/10.1016/j.jhydrol.2019.01.059
SN - 0022-1694
SN - 1879-2707
VL - 571
SP - 390
EP - 405
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Middeldorp, Christel M.
A1 - Mahajan, Anubha
A1 - Horikoshi, Momoko
A1 - Robertson, Neil R.
A1 - Beaumont, Robin N.
A1 - Bradfield, Jonathan P.
A1 - Bustamante, Mariona
A1 - Cousminer, Diana L.
A1 - Day, Felix R.
A1 - De Silva, N. Maneka
A1 - Guxens, Monica
A1 - Mook-Kanamori, Dennis O.
A1 - St Pourcain, Beate
A1 - Warrington, Nicole M.
A1 - Adair, Linda S.
A1 - Ahlqvist, Emma
A1 - Ahluwalia, Tarunveer Singh
A1 - Almgren, Peter
A1 - Ang, Wei
A1 - Atalay, Mustafa
A1 - Auvinen, Juha
A1 - Bartels, Meike
A1 - Beckmann, Jacques S.
A1 - Bilbao, Jose Ramon
A1 - Bond, Tom
A1 - Borja, Judith B.
A1 - Cavadino, Alana
A1 - Charoen, Pimphen
A1 - Chen, Zhanghua
A1 - Coin, Lachlan
A1 - Cooper, Cyrus
A1 - Curtin, John A.
A1 - Custovic, Adnan
A1 - Das, Shikta
A1 - Davies, Gareth E.
A1 - Dedoussis, George V.
A1 - Duijts, Liesbeth
A1 - Eastwood, Peter R.
A1 - Eliasen, Anders U.
A1 - Elliott, Paul
A1 - Eriksson, Johan G.
A1 - Estivill, Xavier
A1 - Fadista, Joao
A1 - Fedko, Iryna O.
A1 - Frayling, Timothy M.
A1 - Gaillard, Romy
A1 - Gauderman, W. James
A1 - Geller, Frank
A1 - Gilliland, Frank
A1 - Gilsanz, Vincente
A1 - Granell, Raquel
A1 - Grarup, Niels
A1 - Groop, Leif
A1 - Hadley, Dexter
A1 - Hakonarson, Hakon
A1 - Hansen, Torben
A1 - Hartman, Catharina A.
A1 - Hattersley, Andrew T.
A1 - Hayes, M. Geoffrey
A1 - Hebebrand, Johannes
A1 - Heinrich, Joachim
A1 - Helgeland, Oyvind
A1 - Henders, Anjali K.
A1 - Henderson, John
A1 - Henriksen, Tine B.
A1 - Hirschhorn, Joel N.
A1 - Hivert, Marie-France
A1 - Hocher, Berthold
A1 - Holloway, John W.
A1 - Holt, Patrick
A1 - Hottenga, Jouke-Jan
A1 - Hypponen, Elina
A1 - Iniguez, Carmen
A1 - Johansson, Stefan
A1 - Jugessur, Astanand
A1 - Kahonen, Mika
A1 - Kalkwarf, Heidi J.
A1 - Kaprio, Jaakko
A1 - Karhunen, Ville
A1 - Kemp, John P.
A1 - Kerkhof, Marjan
A1 - Koppelman, Gerard H.
A1 - Korner, Antje
A1 - Kotecha, Sailesh
A1 - Kreiner-Moller, Eskil
A1 - Kulohoma, Benard
A1 - Kumar, Ashish
A1 - Kutalik, Zoltan
A1 - Lahti, Jari
A1 - Lappe, Joan M.
A1 - Larsson, Henrik
A1 - Lehtimaki, Terho
A1 - Lewin, Alexandra M.
A1 - Li, Jin
A1 - Lichtenstein, Paul
A1 - Lindgren, Cecilia M.
A1 - Lindi, Virpi
A1 - Linneberg, Allan
A1 - Liu, Xueping
A1 - Liu, Jun
A1 - Lowe, William L.
A1 - Lundstrom, Sebastian
A1 - Lyytikainen, Leo-Pekka
A1 - Ma, Ronald C. W.
A1 - Mace, Aurelien
A1 - Magi, Reedik
A1 - Magnus, Per
A1 - Mamun, Abdullah A.
A1 - Mannikko, Minna
A1 - Martin, Nicholas G.
A1 - Mbarek, Hamdi
A1 - McCarthy, Nina S.
A1 - Medland, Sarah E.
A1 - Melbye, Mads
A1 - Melen, Erik
A1 - Mohlke, Karen L.
A1 - Monnereau, Claire
A1 - Morgen, Camilla S.
A1 - Morris, Andrew P.
A1 - Murray, Jeffrey C.
A1 - Myhre, Ronny
A1 - Najman, Jackob M.
A1 - Nivard, Michel G.
A1 - Nohr, Ellen A.
A1 - Nolte, Ilja M.
A1 - Ntalla, Ioanna
A1 - Oberfield, Sharon E.
A1 - Oken, Emily
A1 - Oldehinkel, Albertine J.
A1 - Pahkala, Katja
A1 - Palviainen, Teemu
A1 - Panoutsopoulou, Kalliope
A1 - Pedersen, Oluf
A1 - Pennell, Craig E.
A1 - Pershagen, Goran
A1 - Pitkanen, Niina
A1 - Plomin, Robert
A1 - Power, Christine
A1 - Prasad, Rashmi B.
A1 - Prokopenko, Inga
A1 - Pulkkinen, Lea
A1 - Raikkonen, Katri
A1 - Raitakari, Olli T.
A1 - Reynolds, Rebecca M.
A1 - Richmond, Rebecca C.
A1 - Rivadeneira, Fernando
A1 - Rodriguez, Alina
A1 - Rose, Richard J.
A1 - Salem, Rany
A1 - Santa-Marina, Loreto
A1 - Saw, Seang-Mei
A1 - Schnurr, Theresia M.
A1 - Scott, James G.
A1 - Selzam, Saskia
A1 - Shepherd, John A.
A1 - Simpson, Angela
A1 - Skotte, Line
A1 - Sleiman, Patrick M. A.
A1 - Snieder, Harold
A1 - Sorensen, Thorkild I. A.
A1 - Standl, Marie
A1 - Steegers, Eric A. P.
A1 - Strachan, David P.
A1 - Straker, Leon
A1 - Strandberg, Timo
A1 - Taylor, Michelle
A1 - Teo, Yik-Ying
A1 - Thiering, Elisabeth
A1 - Torrent, Maties
A1 - Tyrrell, Jessica
A1 - Uitterlinden, Andre G.
A1 - van Beijsterveldt, Toos
A1 - van der Most, Peter J.
A1 - van Duijn, Cornelia M.
A1 - Viikari, Jorma
A1 - Vilor-Tejedor, Natalia
A1 - Vogelezang, Suzanne
A1 - Vonk, Judith M.
A1 - Vrijkotte, Tanja G. M.
A1 - Vuoksimaa, Eero
A1 - Wang, Carol A.
A1 - Watkins, William J.
A1 - Wichmann, H-Erich
A1 - Willemsen, Gonneke
A1 - Williams, Gail M.
A1 - Wilson, James F.
A1 - Wray, Naomi R.
A1 - Xu, Shujing
A1 - Xu, Cheng-Jian
A1 - Yaghootkar, Hanieh
A1 - Yi, Lu
A1 - Zafarmand, Mohammad Hadi
A1 - Zeggini, Eleftheria
A1 - Zemel, Babette S.
A1 - Hinney, Anke
A1 - Lakka, Timo A.
A1 - Whitehouse, Andrew J. O.
A1 - Sunyer, Jordi
A1 - Widen, Elisabeth E.
A1 - Feenstra, Bjarke
A1 - Sebert, Sylvain
A1 - Jacobsson, Bo
A1 - Njolstad, Pal R.
A1 - Stoltenberg, Camilla
A1 - Smith, George Davey
A1 - Lawlor, Debbie A.
A1 - Paternoster, Lavinia
A1 - Timpson, Nicholas J.
A1 - Ong, Ken K.
A1 - Bisgaard, Hans
A1 - Bonnelykke, Klaus
A1 - Jaddoe, Vincent W. V.
A1 - Tiemeier, Henning
A1 - Jarvelin, Marjo-Riitta
A1 - Evans, David M.
A1 - Perry, John R. B.
A1 - Grant, Struan F. A.
A1 - Boomsma, Dorret I.
A1 - Freathy, Rachel M.
A1 - McCarthy, Mark I.
A1 - Felix, Janine F.
T1 - The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
BT - design, results and future prospects
JF - European journal of epidemiology
N2 - The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
KW - Genetics
KW - Consortium
KW - Childhood traits and disorders
KW - Longitudinal
Y1 - 2019
U6 - https://doi.org/10.1007/s10654-019-00502-9
SN - 0393-2990
SN - 1573-7284
VL - 34
IS - 3
SP - 279
EP - 300
PB - Springer
CY - Dordrecht
ER -
TY - BOOK
A1 - Rodríguez-Quiles y García, José A.
A1 - de Vugt, Adri
A1 - Oebelsberger, Monika
A1 - Medňanská, Irena
A1 - Dymon, Mirosław
A1 - Jank, Birgit
A1 - García, José M.
A1 - García, María S.
A1 - Arús, Eugènia
A1 - Vicente, Manuel R.
A1 - Díaz, Ana
A1 - González, Germán
A1 - Gutiérrez, Carmen J.
A1 - del Fresno, Beatriz Martínez
A1 - García-Flórez, Llorián
A1 - Quijano, Lucía
A1 - Cañas, Manuel
ED - Rodríguez-Quiles y García, José A.
T1 - Internationale Perspektiven zur Musik(lehrer)ausbildung in Europa
N2 - Das Bildungsgesetz der spanischen Regierung aus dem Jahre 2013 (sp. LOMCE) gilt als Todesstoß für künstlerische Fächer an allgemein bildenden Schulen: Erst 1990 als Pflichtfach eingeführt, wird Musik nun nur noch als Wahlfach angeboten. Auch die Musiklehrerausbildung an den Hochschulen verzeichnet massive Einbußen. Besonders irritierend daran ist, dass die betroffenen Universitätsgremien zu dieser politischen Entscheidung nicht gehört wurden. Damit verschwindet in Spanien das Studienfach Lehramt Musik je nach Universität nach nicht einmal 18 bis 20 Jahren aus dem Studienangebot.
T3 - Potsdamer Schriftenreihe zur Musikpädagogik - 4
Y1 - 2017
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-100717
SN - 978-3-86956-378-7
SN - 2196-5080
SN - 1861-8529
PB - Universitätsverlag Potsdam
CY - Potsdam
ER -
TY - JOUR
A1 - Torrejon, Jose M.
A1 - Schulz, Norbert S.
A1 - Nowak, Michael A.
A1 - Oskinova, Lidia M.
A1 - Rodes-Roca, Jose J.
A1 - Shenar, Tomer
A1 - Wilms, Jörn
T1 - On the radial onset of clumping in the wind of the B0I massive star QV nor
JF - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2 - We present an analysis of a 78 ks Chandra high-energy transmission gratings observation of the B0I star QV Nor, the massive donor of the wind-accreting pulsar 4U1538-52. The neutron star (NS) orbits its companion in a very close orbit (r < 1.4R(*), in units of the stellar radii), thereby allowing probing of the innermost wind regions. The flux of the Fe K alpha line during eclipse reduces to only similar to 30% of the flux measured out of eclipse. This indicates that the majority of Fe fluorescence must be produced in regions close to the NS, at distances smaller than 1R(*) from its surface. The fact that the flux of the continuum decreases to only similar to 3% during eclipse allows for a high contrast of the Fe Ka line fluorescence during eclipse. The line is not resolved and centered at lambda = 1.9368(-0.0018)(+0.0032) angstrom. From the inferred plasma speed limit of v < c Delta lambda/lambda < 800 km s(-1) and range of ionization parameters of log xi =[-1, 2], together with the stellar density profile, we constrain the location of the cold, dense material in the stellar wind of QV Nor using simple geometrical considerations. We then use the Fe K alpha line fluorescence as a tracer of wind clumps and determine that these clumps in the stellar wind of QV Nor (B0I) must already be present at radii r < 1.25R(*), close to the photosphere of the star.
KW - stars: individual (QV Nor, 4U1538+52)
KW - stars: winds, outflows
KW - X-rays: binaries
Y1 - 2015
U6 - https://doi.org/10.1088/0004-637X/810/2/102
SN - 0004-637X
SN - 1538-4357
VL - 810
IS - 2
PB - IOP Publ. Ltd.
CY - Bristol
ER -
TY - JOUR
A1 - Frodl, Thomas
A1 - Janowitz, Deborah
A1 - Schmaal, Lianne
A1 - Tozzi, Leonardo
A1 - Dobrowolny, Henrik
A1 - Stein, Dan J.
A1 - Veltman, Dick J.
A1 - Wittfeld, Katharina
A1 - van Erp, Theo G. M.
A1 - Jahanshad, Neda
A1 - Block, Andrea
A1 - Hegenscheid, Katrin
A1 - Voelzke, Henry
A1 - Lagopoulos, Jim
A1 - Hatton, Sean N.
A1 - Hickie, Ian B.
A1 - Frey, Eva Maria
A1 - Carballedo, Angela
A1 - Brooks, Samantha J.
A1 - Vuletic, Daniella
A1 - Uhlmann, Anne
A1 - Veer, Ilya M.
A1 - Walter, Henrik
A1 - Schnell, Knut
A1 - Grotegerd, Dominik
A1 - Arolt, Volker
A1 - Kugel, Harald
A1 - Schramm, Elisabeth
A1 - Konrad, Carsten
A1 - Zurowski, Bartosz
A1 - Baune, Bernhard T.
A1 - van der Wee, Nic J. A.
A1 - van Tol, Marie-Jose
A1 - Penninx, Brenda W. J. H.
A1 - Thompson, Paul M.
A1 - Hibar, Derrek P.
A1 - Dannlowski, Udo
A1 - Grabe, Hans J.
T1 - Childhood adversity impacts on brain subcortical structures relevant to depression
JF - Journal of psychiatric research
N2 - Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression. (C) 2016 Published by Elsevier Ltd.
KW - Depression
KW - Childhood adversity
KW - MRI
KW - Caudate
KW - Hippocampus
KW - ENIGMA
Y1 - 2016
U6 - https://doi.org/10.1016/j.jpsychires.2016.11.010
SN - 0022-3956
SN - 1879-1379
VL - 86
SP - 58
EP - 65
PB - Elsevier
CY - Oxford
ER -
TY - JOUR
A1 - Kroeger, Janine
A1 - Meidtner, Karina
A1 - Stefan, Norbert
A1 - Guevara, Marcela
A1 - Kerrison, Nicola D.
A1 - Ardanaz, Eva
A1 - Aune, Dagfinn
A1 - Boeing, Heiner
A1 - Dorronsoro, Miren
A1 - Dow, Courtney
A1 - Fagherazzi, Guy
A1 - Franks, Paul W.
A1 - Freisling, Heinz
A1 - Gunter, Marc J.
A1 - Maria Huerta, Jose
A1 - Kaaks, Rudolf
A1 - Key, Timothy J.
A1 - Khaw, Kay Tee
A1 - Krogh, Vittorio
A1 - Kuehn, Tilman
A1 - Mancini, Francesca Romana
A1 - Mattiello, Amalia
A1 - Nilsson, Peter M.
A1 - Olsen, Anja
A1 - Overvad, Kim
A1 - Palli, Domenico
A1 - Ramon Quiros, J.
A1 - Rolandsson, Olov
A1 - Sacerdote, Carlotta
A1 - Sala, Nuria
A1 - Salamanca-Fernandez, Elena
A1 - Sluijs, Ivonne
A1 - Spijkerman, Annemieke M. W.
A1 - Tjonneland, Anne
A1 - Tsilidis, Konstantinos K.
A1 - Tumino, Rosario
A1 - van der Schouw, Yvonne T.
A1 - Forouhi, Nita G.
A1 - Sharp, Stephen J.
A1 - Langenberg, Claudia
A1 - Riboli, Elio
A1 - Schulze, Matthias Bernd
A1 - Wareham, Nicholas J.
T1 - Circulating Fetuin-A and Risk of Type 2 Diabetes
BT - a mendelian randomization analysis
JF - Diabetes : a journal of the American Diabetes Association
N2 - Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. Weaimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28% explained variation). Using the genetic score as instrumental variable of fetuin-A, we observed no significant association of a 50 mu g/mL higher fetuin-A concentration with diabetes risk (hazard ratio 1.02 [95% CI 0.97, 1.07]). Combining our results with those from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (12,171 case subjects) also did not suggest a clear significant relation of fetuin-A with diabetes risk. In conclusion, although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study does not support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population.
Y1 - 2018
U6 - https://doi.org/10.2337/db17-1268
SN - 0012-1797
SN - 1939-327X
VL - 67
IS - 6
SP - 1200
EP - 1205
PB - American Diabetes Association
CY - Alexandria
ER -
TY - JOUR
A1 - Borregaard, Michael K.
A1 - Amorim, Isabel R.
A1 - Borges, Paulo A. V.
A1 - Cabral, Juliano Sarmento
A1 - Fernandez-Palacios, Jose M.
A1 - Field, Richard
A1 - Heaney, Lawrence R.
A1 - Kreft, Holger
A1 - Matthews, Thomas J.
A1 - Olesen, Jens M.
A1 - Price, Jonathan
A1 - Rigal, Francois
A1 - Steinbauer, Manuel J.
A1 - Triantis, Konstantinos A.
A1 - Valente, Luis
A1 - Weigelt, Patrick
A1 - Whittaker, Robert J.
T1 - Oceanic island biogeography through the lens of the general dynamic model: assessment and prospect
JF - Biological reviews
KW - archipelago
KW - diversity theory
KW - general dynamic model
KW - island biogeography
KW - island evolution
KW - trait evolution
KW - volcanic islands
Y1 - 2017
U6 - https://doi.org/10.1111/brv.12256
SN - 1464-7931
SN - 1469-185X
VL - 92
SP - 830
EP - 853
PB - Wiley
CY - Hoboken
ER -
TY - JOUR
A1 - Rothwell, Joseph A.
A1 - Murphy, Neil
A1 - Aleksandrova, Krasimira
A1 - Schulze, Matthias Bernd
A1 - Bešević, Jelena
A1 - Kliemann, Nathalie
A1 - Jenab, Mazda
A1 - Ferrari, Pietro
A1 - Achaintre, David
A1 - Gicquiau, Audrey
A1 - Vozar, Béatrice
A1 - Scalbert, Augustin
A1 - Huybrechts, Inge
A1 - Freisling, Heinz
A1 - Prehn, Cornelia
A1 - Adamski, Jerzy
A1 - Cross, Amanda J.
A1 - Pala, Valeria Maria
A1 - Boutron-Ruault, Marie-Christine
A1 - Dahm, Christina C.
A1 - Overvad, Kim
A1 - Gram, Inger Torhild
A1 - Sandanger, Torkjel M.
A1 - Skeie, Guri
A1 - Jakszyn, Paula
A1 - Tsilidis, Kostas K.
A1 - Hughes, David J.
A1 - van Guelpen, Bethany
A1 - Bodén, Stina
A1 - Sánchez, Maria-José
A1 - Schmidt, Julie A.
A1 - Katzke, Verena
A1 - Kühn, Tilman
A1 - Colorado-Yohar, Sandra
A1 - Tumino, Rosario
A1 - Bueno-de-Mesquita, Bas
A1 - Vineis, Paolo
A1 - Masala, Giovanna
A1 - Panico, Salvatore
A1 - Eriksen, Anne Kirstine
A1 - Tjønneland, Anne
A1 - Aune, Dagfinn
A1 - Weiderpass, Elisabete
A1 - Severi, Gianluca
A1 - Chajès, Véronique
A1 - Gunter, Marc J.
T1 - Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
JF - Clinical gastroenterology and hepatology
N2 - BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.
RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants.
CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
KW - colorectal neoplasm
KW - risk factors
KW - World Cancer Research Fund/American Institute for Cancer Research Recommendations
KW - targeted metabolomics
Y1 - 2020
U6 - https://doi.org/10.1016/j.cgh.2020.11.045
SN - 1542-3565
SN - 1542-7714
VL - 20
SP - E1061
EP - E1082
PB - Elsevier
CY - New York, NY
ER -
TY - JOUR
A1 - Pyšek, Petr
A1 - Pergl, Jan
A1 - Essl, Franz
A1 - Lenzner, Bernd
A1 - Dawson, Wayne
A1 - Kreft, Holger
A1 - Weigelt, Patrick
A1 - Winter, Marten
A1 - Kartesz, John
A1 - Nishino, Misako
A1 - Antonova, Liubov A.
A1 - Barcelona, Julie F.
A1 - Cabezas, Francisco José
A1 - Cárdenas López, Dairon
A1 - Cárdenas-Toro, Juliana
A1 - Castańo, Nicolás
A1 - Chacón, Eduardo
A1 - Chatelain, Cyrille
A1 - Dullinger, Stefan
A1 - Ebel, Aleksandr L.
A1 - Figueiredo, Estrela
A1 - Fuentes, Nicol
A1 - Genovesi, Piero
A1 - Groom, Quentin J.
A1 - Henderson, Lesley
A1 - Inderjit,
A1 - Kupriyanov, Andrey
A1 - Masciadri, Silvana
A1 - Maurel, Noëlie
A1 - Meerman, Jan
A1 - Morozova, Olʹga V.
A1 - Moser, Dietmar
A1 - Nickrent, Daniel
A1 - Nowak, Pauline M.
A1 - Pagad, Shyama
A1 - Patzelt, Annette
A1 - Pelser, Pieter B.
A1 - Seebens, Hanno
A1 - Shu, Wen-sheng
A1 - Thomas, Jacob
A1 - Velayos, Mauricio
A1 - Weber, Ewald
A1 - Wieringa, Jan J.
A1 - Baptiste, Maria P.
A1 - Kleunen, Mark van
T1 - Naturalized alien flora of the world
T1 - Naturalizovaná nepůvodní flóra světa
BT - species diversity, taxonomic and phylogenetic patterns, geographic distribution and global hotspots of plant invasion
BT - druhová diverzita, taxonomické a fylogenetické složení, geografické zákonitosti a globální ohniska rostlinných invazí
JF - Preslia : the journal of the Czech Botanical Society
N2 - Using the recently built Global Naturalized Alien Flora (GloNAF) database, containing data on the distribution of naturalized alien plants in 483 mainland and 361 island regions of the world, we describe patterns in diversity and geographic distribution of naturalized and invasive plant species, taxonomic, phylogenetic and life-history structure of the global naturalized flora as well as levels of naturalization and their determinants. The mainland regions with the highest numbers of naturalized aliens are some Australian states (with New South Wales being the richest on this continent) and several North American regions (of which California with 1753 naturalized plant species represents the worlds richest region in terms of naturalized alien vascular plants). England, Japan, New Zealand and the Hawaiian archipelago harbour most naturalized plants among islands or island groups. These regions also form the main hotspots of the regional levels of naturalization, measured as the percentage of naturalized aliens in the total flora of the region. Such hotspots of relative naturalized species richness appear on both the western and eastern coasts of North America, in north-western Europe, South Africa, south-eastern Australia, New Zealand, and India. High levels of island invasions by naturalized plants are concentrated in the Pacific, but also occur on individual islands across all oceans. The numbers of naturalized species are closely correlated with those of native species, with a stronger correlation and steeper increase for islands than mainland regions, indicating a greater vulnerability of islands to invasion by species that become successfully naturalized. South Africa, India, California, Cuba, Florida, Queensland and Japan have the highest numbers of invasive species. Regions in temperate and tropical zonobiomes harbour in total 9036 and 6774 naturalized species, respectively, followed by 3280 species naturalized in the Mediterranean zonobiome, 3057 in the subtropical zonobiome and 321 in the Arctic. The New World is richer in naturalized alien plants, with 9905 species compared to 7923 recorded in the Old World. While isolation is the key factor driving the level of naturalization on islands, zonobiomes differing in climatic regimes, and socioeconomy represented by per capita GDP, are central for mainland regions. The 11 most widely distributed species each occur in regions covering about one third of the globe or more in terms of the number of regions where they are naturalized and at least 35% of the Earths land surface in terms of those regions areas, with the most widely distributed species Sonchus oleraceus occuring in 48% of the regions that cover 42% of the world area. Other widely distributed species are Ricinus communis, Oxalis corniculata, Portulaca oleracea, Eleusine indica, Chenopodium album, Capsella bursa-pastoris, Stellaria media, Bidens pilosa, Datura stramonium and Echinochloa crus-galli. Using the occurrence as invasive rather than only naturalized yields a different ranking, with Lantana camara (120 regions out of 349 for which data on invasive status are known), Calotropis procera (118), Eichhornia crassipes (113), Sonchus oleraceus (108) and Leucaena leucocephala (103) on top. As to the life-history spectra, islands harbour more naturalized woody species (34.4%) thanmainland regions (29.5%), and fewer annual herbs (18.7% compared to 22.3%). Ranking families by their absolute numbers of naturalized species reveals that Compositae (1343 species), Poaceae (1267) and Leguminosae (1189) contribute most to the global naturalized alien flora. Some families are disproportionally represented by naturalized aliens on islands (Arecaceae, Araceae, Acanthaceae, Amaryllidaceae, Asparagaceae, Convolvulaceae, Rubiaceae, Malvaceae), and much fewer so on mainland (e.g. Brassicaceae, Caryophyllaceae, Boraginaceae). Relating the numbers of naturalized species in a family to its total global richness shows that some of the large species-rich families are over-represented among naturalized aliens (e.g. Poaceae, Leguminosae, Rosaceae, Amaranthaceae, Pinaceae), some under-represented (e.g. Euphorbiaceae, Rubiaceae), whereas the one richest in naturalized species, Compositae, reaches a value expected from its global species richness. Significant phylogenetic signal indicates that families with an increased potential of their species to naturalize are not distributed randomly on the evolutionary tree. Solanum (112 species), Euphorbia (108) and Carex (106) are the genera richest in terms of naturalized species; over-represented on islands are Cotoneaster, Juncus, Eucalyptus, Salix, Hypericum, Geranium and Persicaria, while those relatively richer in naturalized species on the mainland are Atriplex, Opuntia, Oenothera, Artemisia, Vicia, Galium and Rosa. The data presented in this paper also point to where information is lacking and set priorities for future data collection. The GloNAF database has potential for designing concerted action to fill such data gaps, and provide a basis for allocating resources most efficiently towards better understanding and management of plant invasions worldwide.
KW - alien species
KW - distribution
KW - Global Naturalized Alien Flora (GloNAF) database
KW - invasive species
KW - islands
KW - life history
KW - mainland
KW - naturalized species
KW - phylogeny
KW - plant invasion
KW - regional floras
KW - species richness
KW - taxonomy
KW - zonobiome
Y1 - 2017
U6 - https://doi.org/10.23855/preslia.2017.203
SN - 0032-7786
VL - 89
IS - 3
SP - 203
EP - 274
PB - Czech Botanical Soc.
CY - Praha
ER -
TY - JOUR
A1 - Warren, Ben H.
A1 - Simberloff, Daniel
A1 - Ricklefs, Robert E.
A1 - Aguilee, Robin
A1 - Condamine, Fabien L.
A1 - Gravel, Dominique
A1 - Morlon, Helene
A1 - Mouquet, Nicolas
A1 - Rosindell, James
A1 - Casquet, Juliane
A1 - Conti, Elena
A1 - Cornuault, Josselin
A1 - Maria Fernandez-Palacios, Jose
A1 - Hengl, Tomislav
A1 - Norder, Sietze J.
A1 - Rijsdijk, Kenneth F.
A1 - Sanmartin, Isabel
A1 - Strasberg, Dominique
A1 - Triantis, Kostas A.
A1 - Valente, Luis M.
A1 - Whittaker, Robert J.
A1 - Gillespie, Rosemary G.
A1 - Emerson, Brent C.
A1 - Thebaud, Christophe
T1 - Islands as model systems in ecology and evolution: prospects fifty years after MacArthur-Wilson
JF - Ecology letters
N2 - The study of islands as model systems has played an important role in the development of evolutionary and ecological theory. The 50th anniversary of MacArthur and Wilson's (December 1963) article, An equilibrium theory of insular zoogeography', was a recent milestone for this theme. Since 1963, island systems have provided new insights into the formation of ecological communities. Here, building on such developments, we highlight prospects for research on islands to improve our understanding of the ecology and evolution of communities in general. Throughout, we emphasise how attributes of islands combine to provide unusual research opportunities, the implications of which stretch far beyond islands. Molecular tools and increasing data acquisition now permit re-assessment of some fundamental issues that interested MacArthur and Wilson. These include the formation of ecological networks, species abundance distributions, and the contribution of evolution to community assembly. We also extend our prospects to other fields of ecology and evolution - understanding ecosystem functioning, speciation and diversification - frequently employing assets of oceanic islands in inferring the geographic area within which evolution has occurred, and potential barriers to gene flow. Although island-based theory is continually being enriched, incorporating non-equilibrium dynamics is identified as a major challenge for the future.
KW - Community assembly
KW - diversification
KW - ecosystem functioning
KW - genomics
KW - island biogeography
KW - islands as model systems
KW - speciation
Y1 - 2015
U6 - https://doi.org/10.1111/ele.12398
SN - 1461-023X
SN - 1461-0248
VL - 18
IS - 2
SP - 200
EP - 217
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - JOUR
A1 - Perez-Lopez, Raul
A1 - Martin-Velazquez, Saul
A1 - Sanchez-Moral, Sergio
A1 - Patyniak, Magda
A1 - Lopez-Gutierrez, Jose
A1 - Cuezva, Soledad
A1 - Lario, J.
A1 - Silva, P. G.
A1 - Rodriguez-Pascua, M. A.
A1 - Giner-Robles, J. L.
T1 - New insights on speleoseismology: The geothermal gradient and heat flow values in caves for the study of active faults
JF - Quaternary international : the journal of the International Union for Quaternary Research
N2 - Normally in paleoseismology, the study of the tectonic slip-rate is performed in trenches on the fault scarp, or by the estimation of fault movements from the geomorphic features. In this work, we have carried out a paleoseismic analysis of the Benis Fault, located in southeast Spain, combined with a geothermal analysis inside a deep cave related to the fault (-350 m). Thus, we have estimated the last earthquake magnitude and time of occurrence from evidence of ceiling collapse and displaced carbonate blocks inside a cave, which is developed across the fault. The magnitude was obtained from the application of the empirical relationship of the fault parameters and coseismic vertical displacement, yielding a value ranging between M 5.9 and M 6.5. Moreover, we dated this paleoearthquake by the paleontological record of a "Lynx pardinus spelaea", with an age of 65 +/- 18 ka BP. Additionally, we have measured the thermal profile of the Benis Cave (-350 m of depth), from single rock point temperature measurements during 2 years. The temperature profile shows three different parts inside the cave, the shallow heterogeneous thermal zone till 50 m depth; the homogeneous thermal zone 150 m till with constant temperature and the hetero-thermal deep zone, deeper than 150 m and till the deepest zone (350 m). Furthermore, we have estimated the Vertical Geothermal Gradient, 1.85 degrees C/100 m for the deepest zone (-150; -290 m). The temperature increases with depth, showing a reverse thermal profile in comparison with normal gradients in deep caves. Finally, we have calculated the heat flux of 0.46 mWm(2). (C) 2016 Elsevier Ltd and INQUA. All rights reserved.
KW - Speleoseismology
KW - Active fault
KW - Cave
KW - Slip-rate
KW - Heat flux
Y1 - 2017
U6 - https://doi.org/10.1016/j.quaint.2016.11.026
SN - 1040-6182
SN - 1873-4553
VL - 451
SP - 165
EP - 175
PB - Elsevier
CY - Oxford
ER -
TY - JOUR
A1 - Zheng, Ju-Sheng
A1 - Luan, Jian'an
A1 - Sofianopoulou, Eleni
A1 - Imamura, Fumiaki
A1 - Stewart, Isobel D.
A1 - Day, Felix R.
A1 - Pietzner, Maik
A1 - Wheeler, Eleanor
A1 - Lotta, Luca A.
A1 - Gundersen, Thomas E.
A1 - Amiano, Pilar
A1 - Ardanaz, Eva
A1 - Chirlaque, Maria-Dolores
A1 - Fagherazzi, Guy
A1 - Franks, Paul W.
A1 - Kaaks, Rudolf
A1 - Laouali, Nasser
A1 - Mancini, Francesca Romana
A1 - Nilsson, Peter M.
A1 - Onland-Moret, N. Charlotte
A1 - Olsen, Anja
A1 - Overvad, Kim
A1 - Panico, Salvatore
A1 - Palli, Domenico
A1 - Ricceri, Fulvio
A1 - Rolandsson, Olov
A1 - Spijkerman, Annemieke M. W.
A1 - Sanchez, Maria-Jose
A1 - Schulze, Matthias Bernd
A1 - Sala, Nuria
A1 - Sieri, Sabina
A1 - Tjonneland, Anne
A1 - Tumino, Rosario
A1 - van der Schouw, Yvonne T.
A1 - Weiderpass, Elisabete
A1 - Riboli, Elio
A1 - Danesh, John
A1 - Butterworth, Adam S.
A1 - Sharp, Stephen J.
A1 - Langenberg, Claudia
A1 - Forouhi, Nita G.
A1 - Wareham, Nicholas J.
T1 - Plasma vitamin C and type 2 diabetes
BT - genome-wide association study and Mendelian randomization analysis in European populations
JF - Diabetes care
N2 - OBJECTIVE: Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes.
RESEARCH DESIGN AND METHODS: We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants.
RESULTS: We identified 11 genomic regions associated with plasma vitamin C (P < 5 x 10(-8)), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10).
CONCLUSIONS: These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.
Y1 - 2020
U6 - https://doi.org/10.2337/dc20-1328
SN - 0149-5992
SN - 1935-5548
VL - 44
IS - 1
SP - 98
EP - 106
PB - American Diabetes Association
CY - Alexandria
ER -
TY - JOUR
A1 - Merz, Bruno
A1 - Aerts, Jeroen C. J. H.
A1 - Arnbjerg-Nielsen, Karsten
A1 - Baldi, M.
A1 - Becker, Andrew C.
A1 - Bichet, A.
A1 - Bloeschl, G.
A1 - Bouwer, Laurens M.
A1 - Brauer, Achim
A1 - Cioffi, F.
A1 - Delgado, Jose Miguel Martins
A1 - Gocht, M.
A1 - Guzzetti, F.
A1 - Harrigan, S.
A1 - Hirschboeck, K.
A1 - Kilsby, C.
A1 - Kron, W.
A1 - Kwon, H. -H.
A1 - Lall, U.
A1 - Merz, R.
A1 - Nissen, K.
A1 - Salvatti, P.
A1 - Swierczynski, Tina
A1 - Ulbrich, U.
A1 - Viglione, A.
A1 - Ward, P. J.
A1 - Weiler, M.
A1 - Wilhelm, B.
A1 - Nied, Manuela
T1 - Floods and climate: emerging perspectives for flood risk assessment and management
JF - Natural hazards and earth system sciences
N2 - Flood estimation and flood management have traditionally been the domain of hydrologists, water resources engineers and statisticians, and disciplinary approaches abound. Dominant views have been shaped; one example is the catchment perspective: floods are formed and influenced by the interaction of local, catchment-specific characteristics, such as meteorology, topography and geology. These traditional views have been beneficial, but they have a narrow framing. In this paper we contrast traditional views with broader perspectives that are emerging from an improved understanding of the climatic context of floods. We come to the following conclusions: (1) extending the traditional system boundaries (local catchment, recent decades, hydrological/hydraulic processes) opens up exciting possibilities for better understanding and improved tools for flood risk assessment and management. (2) Statistical approaches in flood estimation need to be complemented by the search for the causal mechanisms and dominant processes in the atmosphere, catchment and river system that leave their fingerprints on flood characteristics. (3) Natural climate variability leads to time-varying flood characteristics, and this variation may be partially quantifiable and predictable, with the perspective of dynamic, climate-informed flood risk management. (4) Efforts are needed to fully account for factors that contribute to changes in all three risk components (hazard, exposure, vulnerability) and to better understand the interactions between society and floods. (5) Given the global scale and societal importance, we call for the organization of an international multidisciplinary collaboration and data-sharing initiative to further understand the links between climate and flooding and to advance flood research.
Y1 - 2014
U6 - https://doi.org/10.5194/nhess-14-1921-2014
SN - 1561-8633
VL - 14
IS - 7
SP - 1921
EP - 1942
PB - Copernicus
CY - Göttingen
ER -
TY - JOUR
A1 - Marin-Beloqui, Jose
A1 - Zhang, Guanran
A1 - Guo, Junjun
A1 - Shaikh, Jordan
A1 - Wohrer, Thibaut
A1 - Hosseini, Seyed Mehrdad
A1 - Sun, Bowen
A1 - Shipp, James
A1 - Auty, Alexander J.
A1 - Chekulaev, Dimitri
A1 - Ye, Jun
A1 - Chin, Yi-Chun
A1 - Sullivan, Michael B.
A1 - Mozer, Attila J.
A1 - Kim, Ji-Seon
A1 - Shoaee, Safa
A1 - Clarke, Tracey M.
T1 - Insight into the origin of trapping in polymer/fullerene blends with a systematic alteration of the fullerene to higher adducts
JF - Journal of physical chemistry C
N2 - The bimolecular recombination characteristics of conjugated polymer poly[(4,4'-bis(2-ethylhexyl)dithieno[3,2-b:2',3'-d]silole)-2,6-diyl-alt-(2,5-bis 3-tetradecylthiophen-2-y1 thiazolo 5,4-d thiazole)-2,5diy1] (PDTSiTTz) blended with the fullerene series PC60BM, ICMA, ICBA, and ICTA have been investigated using microsecond and femtosecond transient absorption spectroscopy, in conjunction with electroluminescence measurements and ambient photoemission spectroscopy. The non-Langevin polymer PDTSiTTz allows an inspection of intrinsic bimolecular recombination rates uninhibited by diffusion, while the low oscillator strengths of fullerenes allow polymer features to dominate, and we compare our results to those of the well-known polymer Si-PCPDTBT. Using mu s-TAS, we have shown that the trap -limited decay dynamics of the PDTSiTTz polaron becomes progressively slower across the fullerene series, while those of Si-PCPDTBT are invariant. Electroluminescence measurements showed an unusual double peak in pristine PDTSiTTz, attributed to a low energy intragap charge transfer state, likely interchain in nature. Furthermore, while the pristine PDTSiTTz showed a broad, low-intensity density of states, the ICBA and ICTA blends presented a virtually identical DOS to Si-PCPDTBT and its blends. This has been attributed to a shift from a delocalized, interchain highest occupied molecular orbital (HOMO) in the pristine material to a dithienosilole-centered HOMO in the blends, likely a result of the bulky fullerenes increasing interchain separation. This HOMO localization had a side effect of progressively shifting the polymer HOMO to shallower energies, which was correlated with the observed decrease in bimolecular recombination rate and increased "trap" depth. However, since the density of tail states remained the same, this suggests that the traditional viewpoint of "trapping" being dominated by tail states may not encompass the full picture and that the breadth of the DOS may also have a strong influence on bimolecular recombination.
Y1 - 2022
U6 - https://doi.org/10.1021/acs.jpcc.1c10378
SN - 1932-7447
SN - 1932-7455
VL - 126
IS - 5
SP - 2708
EP - 2719
PB - American Chemical Society
CY - Washington
ER -
TY - JOUR
A1 - Fortesa, Josep
A1 - García-Comendador, Julian
A1 - Calsamiglia, A.
A1 - López-Tarazón, José Andrés
A1 - Latron, J.
A1 - Alorda, B.
A1 - Estrany, Joan
T1 - Comparison of stage/discharge rating curves derived from different recording systems
BT - Consequences for streamflow data and water management in a Mediterranean island
JF - The science of the total environment : an international journal for scientific research into the environment and its relationship with man
N2 - Obtaining representative hydrometric values is essential for characterizing extreme events, hydrological dynamics and detecting possible changes on the long-term hydrology. Reliability of streamflow data requires a temporal continuity and a maintenance of the gauging stations, which data are affected by epistemic and random sources of error. An assessment of discharge meterings' and stage-discharge rating curves' uncertainties were carried out by comparing the accuracy of the measuring instruments of two different hydrometric networks (i.e., one analogical and one digital) established in the same river location at the Mediterranean island of Mallorca. Furthermore, the effects of such uncertainties were assessed on the hydrological dynamics, considering the significant global change impacts beset this island. Evaluation was developed at four representative gauging stations of the hydrographic network with analogic (≈40 years) and digital (≈10 years) data series. The study revealed that the largest source of uncertainty in the analogical (28 to 274%) and in the digital (17–37%) networks were the stage-discharge rating curves. Their impact on the water resources was also evaluated at the event and annual scales, resulting in an average difference of water yields of 183% and 142% respectively. Such improvement on the comprehension of hydrometric networks uncertainties will dramatically benefit the interpretation of the long-term streamflow by providing better insights into the hydrologic and flood hazard planning, management and modelling.
KW - Hydrometric networks
KW - Stage-discharge
KW - Metering
KW - Uncertainty
KW - Error propagation
Y1 - 2019
U6 - https://doi.org/10.1016/j.scitotenv.2019.02.158
SN - 0048-9697
SN - 1879-1026
VL - 665
SP - 968
EP - 981
PB - Elsevier Science
CY - Amsterdam
ER -
TY - JOUR
A1 - Thomas, Jessica E.
A1 - Carvalho, Gary R.
A1 - Haile, James
A1 - Rawlence, Nicolas J.
A1 - Martin, Michael D.
A1 - Ho, Simon Y. W.
A1 - Sigfusson, Arnor P.
A1 - Josefsson, Vigfus A.
A1 - Frederiksen, Morten
A1 - Linnebjerg, Jannie F.
A1 - Castruita, Jose A. Samaniego
A1 - Niemann, Jonas
A1 - Sinding, Mikkel-Holger S.
A1 - Sandoval-Velasco, Marcela
A1 - Soares, Andre E. R.
A1 - Lacy, Robert
A1 - Barilaro, Christina
A1 - Best, Juila
A1 - Brandis, Dirk
A1 - Cavallo, Chiara
A1 - Elorza, Mikelo
A1 - Garrett, Kimball L.
A1 - Groot, Maaike
A1 - Johansson, Friederike
A1 - Lifjeld, Jan T.
A1 - Nilson, Goran
A1 - Serjeanston, Dale
A1 - Sweet, Paul
A1 - Fuller, Errol
A1 - Hufthammer, Anne Karin
A1 - Meldgaard, Morten
A1 - Fjeldsa, Jon
A1 - Shapiro, Beth
A1 - Hofreiter, Michael
A1 - Stewart, John R.
A1 - Gilbert, M. Thomas P.
A1 - Knapp, Michael
T1 - Demographic reconstruction from ancient DNA supports rapid extinction of the great auk
JF - eLife
N2 - The great auk was once abundant and distributed across the North Atlantic. It is now extinct, having been heavily exploited for its eggs, meat, and feathers. We investigated the impact of human hunting on its demise by integrating genetic data, GPS-based ocean current data, and analyses of population viability. We sequenced complete mitochondrial genomes of 41 individuals from across the species' geographic range and reconstructed population structure and population dynamics throughout the Holocene. Taken together, our data do not provide any evidence that great auks were at risk of extinction prior to the onset of intensive human hunting in the early 16th century. In addition, our population viability analyses reveal that even if the great auk had not been under threat by environmental change, human hunting alone could have been sufficient to cause its extinction. Our results emphasise the vulnerability of even abundant and widespread species to intense and localised exploitation.
Y1 - 2019
U6 - https://doi.org/10.7554/eLife.47509
SN - 2050-084X
VL - 8
PB - eLife Sciences Publications
CY - Cambridge
ER -
TY - JOUR
A1 - Thomas, Jessica E.
A1 - Carvalho, Gary R.
A1 - Haile, James
A1 - Martin, Michael D.
A1 - Castruita, Jose A. Samaniego
A1 - Niemann, Jonas
A1 - Sinding, Mikkel-Holger S.
A1 - Sandoval-Velasco, Marcela
A1 - Rawlence, Nicolas J.
A1 - Fuller, Errol
A1 - Fjeldsa, Jon
A1 - Hofreiter, Michael
A1 - Stewart, John R.
A1 - Gilbert, M. Thomas P.
A1 - Knapp, Michael
T1 - An ‛Aukward’ tale
BT - a genetic approach to discover the whereabouts of the Last Great Auks
JF - Genes
N2 - One hundred and seventy-three years ago, the last two Great Auks, Pinguinus impennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the location of their skins has remained a mystery. In 1999, Great Auk expert Errol Fuller proposed a list of five potential candidate skins in museums around the world. Here we take a palaeogenomic approach to test which—if any—of Fuller’s candidate skins likely belong to either of the two birds. Using mitochondrial genomes from the five candidate birds (housed in museums in Bremen, Brussels, Kiel, Los Angeles, and Oldenburg) and the organs of the last two known individuals, we partially solve the mystery that has been on Great Auk scholars’ minds for generations and make new suggestions as to the whereabouts of the still-missing skin from these two birds.
KW - ancient DNA
KW - extinct birds
KW - mitochondrial genome
KW - museum specimens
KW - palaeogenomics
Y1 - 2017
U6 - https://doi.org/10.3390/genes8060164
SN - 2073-4425
VL - 8
IS - 6
SP - 164
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Park, Jungsu
A1 - Batalla, Ramon J.
A1 - Birgand, Francois
A1 - Esteves, Michel
A1 - Gentile, Francesco
A1 - Harrington, Joseph R.
A1 - Navratil, Oldrich
A1 - Lopez-Tarazon, José Andrés
A1 - Vericat, Damia
T1 - Influences of Catchment and River Channel Characteristics on the Magnitude and Dynamics of Storage and Re-Suspension of Fine Sediments in River Beds
JF - Water
N2 - Fine particles or sediments are one of the important variables that should be considered for the proper management of water quality and aquatic ecosystems. In the present study, the effect of catchment characteristics on the performance of an already developed model for the estimation of fine sediments dynamics between the water column and sediment bed was tested, using 13 catchments distributed worldwide. The model was calibrated to determine two optimal model parameters. The first is the filtration parameter, which represents the filtration of fine sediments through pores of the stream bed during the recession period of a flood event. The second parameter is the bed erosion parameter that represents the active layer, directly related to the re-suspension of fine sediments during a flood event. A dependency of the filtration parameter with the catchment area was observed in catchments smaller than 100 km(2), whereas no particular relationship was observed for larger catchments (>100 km(2)). In contrast, the bed erosion parameter does not show a noticeable dependency with the area or other environmental characteristics. The model estimated the mass of fine sediments released from the sediment bed to the water column during flood events in the 13 catchments within 23% bias.
KW - bed erosion
KW - catchment area
KW - filtration
KW - sediment accumulation
KW - sediment bed fluidization
KW - sediment re-suspension
Y1 - 2019
U6 - https://doi.org/10.3390/w11050878
SN - 2073-4441
VL - 11
IS - 5
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - González-Fortes, Gloria M.
A1 - Kolbe, Ben
A1 - Fernandes, Daniel
A1 - Meleg, Ioana N.
A1 - Garcia-Vazquez, Ana
A1 - Pinto-Llona, Ana C.
A1 - Constantin, Silviu
A1 - de Torres, Trino J.
A1 - Ortiz, Jose E.
A1 - Frischauf, Christine
A1 - Rabeder, Gernot
A1 - Hofreiter, Michael
A1 - Barlow, Axel
T1 - Ancient DNA reveals differences in behaviour and sociality between brown bears and extinct cave bears
JF - Molecular ecology
N2 - Ancient DNA studies have revolutionized the study of extinct species and populations, providing insights on phylogeny, phylogeography, admixture and demographic history. However, inferences on behaviour and sociality have been far less frequent. Here, we investigate the complete mitochondrial genomes of extinct Late Pleistocene cave bears and middle Holocene brown bears that each inhabited multiple geographically proximate caves in northern Spain. In cave bears, we find that, although most caves were occupied simultaneously, each cave almost exclusively contains a unique lineage of closely related haplotypes. This remarkable pattern suggests extreme fidelity to their birth site in cave bears, best described as homing behaviour, and that cave bears formed stable maternal social groups at least for hibernation. In contrast, brown bears do not show any strong association of mitochondrial lineage and cave, suggesting that these two closely related species differed in aspects of their behaviour and sociality. This difference is likely to have contributed to cave bear extinction, which occurred at a time in which competition for caves between bears and humans was likely intense and the ability to rapidly colonize new hibernation sites would have been crucial for the survival of a species so dependent on caves for hibernation as cave bears. Our study demonstrates the potential of ancient DNA to uncover patterns of behaviour and sociality in ancient species and populations, even those that went extinct many tens of thousands of years ago.
KW - ancient DNA
KW - extinction
KW - homing
KW - sociality
KW - Ursus arctos
KW - Ursus spelaeus
Y1 - 2016
U6 - https://doi.org/10.1111/mec.13800
SN - 0962-1083
SN - 1365-294X
VL - 25
SP - 4907
EP - 4918
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - JOUR
A1 - Gonzalez-Chavarria, Ivan
A1 - Duprat, Felix
A1 - Roa, Francisco J.
A1 - Jara, Nery
A1 - Toledo, Jorge R.
A1 - Miranda, Felipe
A1 - Becerra, Jose
A1 - Inostroza, Alejandro
A1 - Kelling, Alexandra
A1 - Schilde, Uwe
A1 - Heydenreich, Matthias
A1 - Paz, Cristian
T1 - Maytenus disticha extract and an isolated β-Dihydroagarofuran induce mitochondrial depolarization and apoptosis in human cancer cells by increasing mitochondrial reactive oxygen species
JF - Biomolecules
N2 - Maytenus disticha (Hook F.), belonging to the Celastraceae family, is an evergreen shrub, native of the central southern mountains of Chile. Previous studies demonstrated that the total extract of M. disticha (MD) has an acetylcholinesterase inhibitory activity along with growth regulatory and insecticidal activities. beta-Dihydroagarofurans sesquiterpenes are the most active components in the plant. However, its activity in cancer has not been analyzed yet. Here, we demonstrate that MD has a cytotoxic activity on breast (MCF-7), lung (PC9), and prostate (C4-2B) human cancer cells with an IC50 (mu g/mL) of 40, 4.7, and 5 mu g/mL, respectively, an increasing Bax/Bcl2 ratio, and inducing a mitochondrial membrane depolarization. The beta-dihydroagarofuran-type sesquiterpene (MD-6), dihydromyricetin (MD-9), and dihydromyricetin-3-O-beta-glucoside (MD-10) were isolated as the major compounds from MD extracts. From these compounds, only MD-6 showed cytotoxic activity on MCF-7, PC9, and C4-2B with an IC50 of 31.02, 17.58, and 42.19 mu M, respectively. Furthermore, the MD-6 increases cell ROS generation, and MD and MD-6 induce a mitochondrial superoxide generation and apoptosis on MCF-7, PC9, and C4-2B, which suggests that the cytotoxic effect of MD is mediated in part by the beta-dihydroagarofuran-type that induces apoptosis by a mitochondrial dysfunction.
KW - Maytenus disticha
KW - beta-dihydroagarofuran-type sesquiterpene
KW - dihydromyricetin
KW - dihydromyricetin-3-O-beta-glucoside
KW - cytotoxic
KW - activity
KW - Mitochondrial ROS
Y1 - 2020
U6 - https://doi.org/10.3390/biom10030377
SN - 2218-273X
VL - 10
IS - 3
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Abercrombie, Laura Good
A1 - Anderson, Cynthia M.
A1 - Baldwin, Bruce G.
A1 - Bang, In-Chul
A1 - Beldade, Ricardo
A1 - Bernardi, Giacomo
A1 - Boubou, Angham
A1 - Branca, Antoine
A1 - Bretagnolle, Francois
A1 - Bruford, Michael W.
A1 - Buonamici, Anna
A1 - Burnett, Robert K.
A1 - Canal, D.
A1 - Cardenas, H.
A1 - Caullet, Coraline
A1 - Chen, S. Y.
A1 - Chun, Y. J.
A1 - Cossu, C.
A1 - Crane, Charles F.
A1 - Cros-Arteil, Sandrine
A1 - Cudney-Bueno, Richard
A1 - Danti, Roberto
A1 - Davila, José Antonio
A1 - Della Rocca, Gianni
A1 - Dobata, Shigeto
A1 - Dunkle, Larry D.
A1 - Dupas, Stephane and others
T1 - Permanent genetic resources added to molecular ecology resources database 1 January 2009-30 April 2009
N2 - This article documents the addition of 283 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Agalinis acuta; Ambrosia artemisiifolia; Berula erecta; Casuarius casuarius; Cercospora zeae-maydis; Chorthippus parallelus; Conyza canadensis; Cotesia sesamiae; Epinephelus acanthistius; Ficedula hypoleuca; Grindelia hirsutula; Guadua angustifolia; Leucadendron rubrum; Maritrema novaezealandensis; Meretrix meretrix; Nilaparvata lugens; Oxyeleotris marmoratus; Phoxinus neogaeus; Pristomyrmex punctatus; Pseudobagrus brevicorpus; Seiridium cardinale; Stenopsyche marmorata; Tetranychus evansi and Xerus inauris. These loci were cross-tested on the following species: Agalinis decemloba; Agalinis tenella; Agalinis obtusifolia; Agalinis setacea; Agalinis skinneriana; Cercospora zeina; Cercospora kikuchii; Cercospora sorghi; Mycosphaerella graminicola; Setosphaeria turcica; Magnaporthe oryzae; Cotesia flavipes; Cotesia marginiventris; Grindelia Xpaludosa; Grindelia chiloensis; Grindelia fastigiata; Grindelia lanceolata; Grindelia squarrosa; Leucadendron coniferum; Leucadendron salicifolium; Leucadendron tinctum; Leucadendron meridianum; Laodelphax striatellus; Sogatella furcifera; Phoxinus eos; Phoxinus rigidus; Phoxinus brevispinosus; Phoxinus bicolor; Tetranychus urticae; Tetranychus turkestani; Tetranychus ludeni; Tetranychus neocaledonicus; Tetranychus amicus; Amphitetranychus viennensis; Eotetranychus rubiphilus; Eotetranychus tiliarium; Oligonychus perseae; Panonychus citri; Bryobia rubrioculus; Schizonobia bundi; Petrobia harti; Xerus princeps; Spermophilus tridecemlineatus and Sciurus carolinensis.
Y1 - 2009
UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291755-0998
U6 - https://doi.org/10.1111/j.1755-0998.2009.02746.x
SN - 1755-098X
ER -
TY - JOUR
A1 - Westendorf, Christian
A1 - Negrete, Jose
A1 - Bae, Albert J.
A1 - Sandmann, Rabea
A1 - Bodenschatz, Eberhard
A1 - Beta, Carsten
T1 - Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations
JF - Proceedings of the National Academy of Sciences of the United States of America
N2 - The rapid reorganization of the actin cytoskeleton in response to external stimuli is an essential property of many motile eukaryotic cells. Here, we report evidence that the actin machinery of chemotactic Dictyostelium cells operates close to an oscillatory instability. When averaging the actin response of many cells to a short pulse of the chemoattractant cAMP, we observed a transient accumulation of cortical actin reminiscent of a damped oscillation. At the single-cell level, however, the response dynamics ranged from short, strongly damped responses to slowly decaying, weakly damped oscillations. Furthermore, in a small subpopulation, we observed self-sustained oscillations in the cortical F-actin concentration. To substantiate that an oscillatory mechanism governs the actin dynamics in these cells, we systematically exposed a large number of cells to periodic pulse trains of different frequencies. Our results indicate a resonance peak at a stimulation period of around 20 s. We propose a delayed feedback model that explains our experimental findings based on a time-delay in the regulatory network of the actin system. To test the model, we performed stimulation experiments with cells that express GFP-tagged fusion proteins of Coronin and actin-interacting protein 1, as well as knockout mutants that lack Coronin and actin-interacting protein 1. These actin-binding proteins enhance the disassembly of actin filaments and thus allow us to estimate the delay time in the regulatory feedback loop. Based on this independent estimate, our model predicts an intrinsic period of 20 s, which agrees with the resonance observed in our periodic stimulation experiments.
KW - Dictyostelium discoideum
KW - microfluidics
KW - caged cAMP
KW - delay-differential equation
Y1 - 2013
U6 - https://doi.org/10.1073/pnas.1216629110
SN - 0027-8424
VL - 110
IS - 10
SP - 3853
EP - 3858
PB - National Acad. of Sciences
CY - Washington
ER -
TY - JOUR
A1 - Kissling, W. D.
A1 - Dormann, Carsten F.
A1 - Groeneveld, Juergen
A1 - Hickler, Thomas
A1 - Kühn, Ingolf
A1 - McInerny, Greg J.
A1 - Montoya, Jose M.
A1 - Römermann, Christine
A1 - Schiffers, Katja
A1 - Schurr, Frank Martin
A1 - Singer, Alexander
A1 - Svenning, Jens-Christian
A1 - Zimmermann, Niklaus E.
A1 - O'Hara, Robert B.
T1 - Towards novel approaches to modelling biotic interactions in multispecies assemblages at large spatial extents
JF - Journal of biogeography
N2 - Aim Biotic interactions within guilds or across trophic levels have widely been ignored in species distribution models (SDMs). This synthesis outlines the development of species interaction distribution models (SIDMs), which aim to incorporate multispecies interactions at large spatial extents using interaction matrices. Location Local to global. Methods We review recent approaches for extending classical SDMs to incorporate biotic interactions, and identify some methodological and conceptual limitations. To illustrate possible directions for conceptual advancement we explore three principal ways of modelling multispecies interactions using interaction matrices: simple qualitative linkages between species, quantitative interaction coefficients reflecting interaction strengths, and interactions mediated by interaction currencies. We explain methodological advancements for static interaction data and multispecies time series, and outline methods to reduce complexity when modelling multispecies interactions. Results Classical SDMs ignore biotic interactions and recent SDM extensions only include the unidirectional influence of one or a few species. However, novel methods using error matrices in multivariate regression models allow interactions between multiple species to be modelled explicitly with spatial co-occurrence data. If time series are available, multivariate versions of population dynamic models can be applied that account for the effects and relative importance of species interactions and environmental drivers. These methods need to be extended by incorporating the non-stationarity in interaction coefficients across space and time, and are challenged by the limited empirical knowledge on spatio-temporal variation in the existence and strength of species interactions. Model complexity may be reduced by: (1) using prior ecological knowledge to set a subset of interaction coefficients to zero, (2) modelling guilds and functional groups rather than individual species, and (3) modelling interaction currencies and species effect and response traits. Main conclusions There is great potential for developing novel approaches that incorporate multispecies interactions into the projection of species distributions and community structure at large spatial extents. Progress can be made by: (1) developing statistical models with interaction matrices for multispecies co-occurrence datasets across large-scale environmental gradients, (2) testing the potential and limitations of methods for complexity reduction, and (3) sampling and monitoring comprehensive spatio-temporal data on biotic interactions in multispecies communities.
KW - Community ecology
KW - ecological networks
KW - global change
KW - guild assembly
KW - multidimensional complexity
KW - niche theory
KW - prediction
KW - species distribution model
KW - species interactions
KW - trait-based community modules
Y1 - 2012
U6 - https://doi.org/10.1111/j.1365-2699.2011.02663.x
SN - 0305-0270
VL - 39
IS - 12
SP - 2163
EP - 2178
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - JOUR
A1 - Schulz, Jennifer J.
A1 - Cayuela, Luis
A1 - Rey-Benayas, Jose M.
A1 - Schröder-Esselbach, Boris
T1 - Factors influencing vegetation cover change in Mediterranean Central Chile (1975-2008)
JF - Applied vegetation science : official organ of the International Association for Vegetation Science
N2 - Questions: Which are the factors that influence forest and shrubland loss and regeneration and their underlying drivers?
Location: Central Chile, a world biodiversity hotspot.
Methods: Using land-cover data from the years 1975, 1985, 1999 and 2008, we fitted classification trees and multiple logistic regression models to account for the relationship between different trajectories of vegetation change and a range of biophysical and socio-economic factors.
Results: The variables that most consistently showed significant effects on vegetation change across all time-intervals were slope and distance to primary roads. We found that forest and shrubland loss on one side and regeneration on the other often displayed opposite patterns in relation to the different explanatory variables. Deforestation was positively related to distance to primary roads and to distance within forest edges and was favoured by a low insolation and a low slope. In turn, forest regeneration was negatively related to the distance to primary roads and positively to the distance to the nearest forest patch, insolation and slope. Shrubland loss was positively influenced by slope and distance to cities and primary roads and negatively influenced by distance to rivers. Conversely, shrubland regeneration was negatively related to slope, distance to cities and distance to primary roads and positively related to distance from existing forest patches and distance to rivers.
Conclusions: This article reveals how biophysical and socioeconomic factors influence vegetation cover change and the underlying social, political and economical drivers. This assessment provides a basis for management decisions, considering the crucial role of perennial vegetation cover for sustaining biodiversity and ecosystem services.
KW - Deforestation
KW - Driving forces
KW - Forest regeneration
KW - Land-cover change
KW - Shrubland regeneration
Y1 - 2011
U6 - https://doi.org/10.1111/j.1654-109X.2011.01135.x
SN - 1402-2001
VL - 14
IS - 4
SP - 571
EP - 582
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - JOUR
A1 - Lobera, G.
A1 - Batalla Villanueva, Ramon J.
A1 - Vericat, D.
A1 - López-Tarazón, José Andrés
A1 - Tena, A.
T1 - Sediment transport in two mediterranean regulated rivers
JF - The science of the total environment : an international journal for scientific research into the environment and its relationship with man
N2 - Mediterranean climate is characterized by highly irregular rainfall patterns with marked differences between wet and dry seasons which lead to highly variable hydrological fluvial regimes. As a result, and in order to ensure water availability and reduce its temporal variability, a high number of large dams were built during the 20th century (more than 3500 located in Mediterranean rivers). Dams modify the flow regime but also interrupt the continuity of sediment transfer along the river network, thereby changing its functioning as an ecosystem. Within this context, the present paper aims to assess the suspended sediment loads and dynamics of two climatically contrasting Mediterranean regulated rivers (i.e. the Esera and Siurana) during a 2-yr period. Key findings indicate that floods were responsible for 92% of the total suspended sediment load in the River Siurana, while this percentage falls to 70% for the Esera, indicating the importance of baseflows on sediment transport in this river. This fact is related to the high sediment availability, with the Esera acting as a non-supply-limited catchment due to the high productivity of the sources (i.e. badlands). In contrast, the Siurana can be considered a supply-limited system due to its low geomorphic activity and reduced sediment availability, with suspended sediment concentration remaining low even for high magnitude flood events. Reservoirs in both rivers reduce sediment load up to 90%, although total runoff is only reduced in the case of the River Esera. A remarkable fact is the change of the hydrological character of the River Lem downstream for the dam, shifting from a humid mountainous river regime to a quasi-invariable pattern, whereas the Siurana experiences the opposite effect, changing from a flashy Mediterranean river to a more constant flow regime below the dam. (C) 2015 Elsevier B.V. All rights reserved.
KW - Suspended sediment transport
KW - Sediment load
KW - Flow regime
KW - Barasona Reservoir
KW - Siurana Reservoir
KW - Ebro basin
KW - Mediterranean
Y1 - 2016
U6 - https://doi.org/10.1016/j.scitotenv.2015.08.018
SN - 0048-9697
SN - 1879-1026
VL - 540
SP - 101
EP - 113
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - López-Tarazón, José Andrés
A1 - Lopez, Pilar
A1 - Lobera, Gemma
A1 - Batalla Villanueva, Ramon J.
T1 - Suspended sediment, carbon and nitrogen transport in a regulated Pyrenean river
JF - The science of the total environment : an international journal for scientific research into the environment and its relationship with man
N2 - Regulation alters the characteristics of riversty transforming parts of them into lakes, affecting their hydrology and also the physical, chemical, and biological characteristics and dynamics. Reservoirs have proven to be very effective retaining particulate materials, thereby avoiding the downstream transport of suspended sediment and the chemical substances associated with it (e.g. Carbon, C or Nitrogen, N). The study of fluvial transport of C and N is of great interest since river load represents a major link to the global C and N cycles. Moreover, reservoirs are the most important sinks for organic carbon among inland waters and have a potential significance as nitrogen sinks. In this respect, this paper investigates the effects of a Pyrenean reservoir on the runoff, suspended sediment, C and N derived from the highly active Esera and Isabena rivets. Key findings indicate that the reservoir causes a considerable impact on the Esera-Isabena river fluxes, reducing them dramatically as almost all the inputs are retained within the reservoir. Despite the very dry study year (2011-2012), it can be calculated that almost 300,000 t of suspended sediment were deposited into the Barasona Reservoir, from which more than 16,000 were C (i.e. 2200 t as organic C) and 222 t were N. These values may not be seen as remarkable in a wider global context but, assuming that around 30 hm(3) of sediment are currently stored in the reservoir, figures would increase up to ca. 2.6 x 10(6) t of C (i.e. 360,000 t of organic C) and 35,000 t of N. Nevertheless, these values are indicative and should be treated with caution as there is incomplete understanding of all the processes which affect C and N. Further investigation to establish a more complete picture of C and N yields and budgets by monitoring the different processes involved is essential. (C) 2015 Elsevier B.V. All rights reserved.
KW - Suspended sediment
KW - Carbon
KW - Nitrogen
KW - Temporal dynamics
KW - Barasona Reservoir
KW - River Esera
KW - Ebro basin
Y1 - 2016
U6 - https://doi.org/10.1016/j.scitotenv.2015.06.132
SN - 0048-9697
SN - 1879-1026
VL - 540
SP - 133
EP - 143
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Quintana, Xavier D.
A1 - Arim, Matias
A1 - Badosa, Anna
A1 - Maria Blanco, Jose
A1 - Boix, Dani
A1 - Brucet, Sandra
A1 - Compte, Jordi
A1 - Egozcue, Juan J.
A1 - de Eyto, Elvira
A1 - Gaedke, Ursula
A1 - Gascon, Stephanie
A1 - Gil de Sola, Luis
A1 - Irvine, Kenneth
A1 - Jeppesen, Erik
A1 - Lauridsen, Torben L.
A1 - Lopez-Flores, Rocio
A1 - Mehner, Thomas
A1 - Romo, Susana
A1 - Sondergaard, Martin
T1 - Predation and competition effects on the size diversity of aquatic communities
JF - Aquatic sciences : research across boundaries
N2 - Body size has been widely recognised as a key factor determining community structure in ecosystems. We analysed size diversity patterns of phytoplankton, zooplankton and fish assemblages in 13 data sets from freshwater and marine sites with the aim to assess whether there is a general trend in the effect of predation and resource competition on body size distribution across a wide range of aquatic ecosystems. We used size diversity as a measure of the shape of size distribution. Size diversity was computed based on the Shannon-Wiener diversity expression, adapted to a continuous variable, i.e. as body size. Our results show that greater predation pressure was associated with reduced size diversity of prey at all trophic levels. In contrast, competition effects depended on the trophic level considered. At upper trophic levels (zooplankton and fish), size distributions were more diverse when potential resource availability was low, suggesting that competitive interactions for resources promote diversification of aquatic communities by size. This pattern was not found for phytoplankton size distributions where size diversity mostly increased with low zooplankton grazing and increasing nutrient availability. Relationships we found were weak, indicating that predation and competition are not the only determinants of size distribution. Our results suggest that predation pressure leads to accumulation of organisms in the less predated sizes, while resource competition tends to favour a wider size distribution.
KW - Phytoplankton
KW - Zooplankton
KW - Fish
KW - Size distribution
KW - Predation
KW - Competition
KW - Compositional data analysis
Y1 - 2015
U6 - https://doi.org/10.1007/s00027-014-0368-1
SN - 1015-1621
SN - 1420-9055
VL - 77
IS - 1
SP - 45
EP - 57
PB - Springer
CY - Basel
ER -
TY - JOUR
A1 - Lobera, Gemma
A1 - Andres-Domenech, Ignacio
A1 - López-Tarazón, José Andrés
A1 - Millan-Romero, Pedro
A1 - Valles, Francisco
A1 - Vericat, Damia
A1 - Batalla Villanueva, Ramon J.
T1 - Bed disturbance below dams: observations from two Mediterranean rivers
JF - Land degradation & development
N2 - River-bed disturbance and associated sedimentary processes such as particle mobility are central elements to assess river ecosystem functioning. Dams change river dynamics affecting the magnitude and frequency of biophysical elements that depend on them. This paper examines the effects of two dams different in size, management, and location, on the flow regime, flood competence, and bed disturbance in two contrasting Mediterranean rivers, the Esera and the Siurana. For this purpose, two reaches on each river were monitored upstream and downstream from reservoirs. Several monitoring and modeling techniques were used to characterize flow competence, particle entrainment, and the volumes of sediments eroded and deposited after floods. The flow regime of the Esera has been modified from nivo-pluvial regime, typical of humid mountainous environments, to that observed in dry semiarid regions, in which high magnitude but low frequency floods are the dominant processes. Conversely, the flow regime of the Siurana has changed from a typical Mediterranean stream to a regime observed in more temperate environments, with more permanent and stable flows. Both rivers show notably physical changes, with channels clearly less dynamic below the dams. The lack of competent flows together with the sediment deficit associated with the dams has led to less active fluvial environments (reduced particle mobility and bed scour dynamics), a fact that affects instream habitat structure (more uniform grain size distribution, less physical heterogeneity, more stable flows), overall contributing to the degradation of the stream corridor and the subsequent environmental deterioration of the whole fluvial landscape. Copyright (c) 2017 John Wiley & Sons, Ltd.
KW - flow regime
KW - dams
KW - bed disturbance
KW - sediment mobility
KW - Mediterranean rivers
Y1 - 2017
U6 - https://doi.org/10.1002/ldr.2785
SN - 1085-3278
SN - 1099-145X
VL - 28
SP - 2493
EP - 2512
PB - Wiley
CY - Hoboken
ER -
TY - JOUR
A1 - Halfar, Jochen
A1 - Godinez-Orta, Lucio
A1 - Mutti, Maria
A1 - Valdez-Holguin, J. E.
A1 - Borges, Jose M.
T1 - Nutrient and temperature controls on modern carbonate production : an example from the Gulf of California, Mexico
N2 - In addition to salinity and temperature, nutrient concentrations in surface waters are known to have a significant impact on distribution of carbonate-producing biota, but have never been quantitatively evaluated against different temperatures along a latitudinal transect. The western coast of the Gulf of California, Mexico, presents a natural laboratory for investigating the influence of oceanographic parameters such as salinity, temperature, and chlorophyll a, a proxy for nutrients, on the composition of a range of modern heterozoan and photozoan carbonate environments along a north-south latitudinal gradient spanning the entire warm-temperate realm (29degreesN-23degreesN). Chlorophyll a, measured in situ at half-hour resolution, is highly variable throughout the year due to short-term upwelling, and increases significantly from the southern to northern Gulf of California. Salinity, in contrast, fluctuates little and remains at an average of 35%. From south to north, carbonate production ranges from oligotrophic- mesotrophic, coral reefdominated shallow-water areas (minimum temperature 18.6 degreesC) through mesotrophic-eutrophic, red algal-dominated, inner-shelf carbonate production in the central gulf (minimum temperature 16 degreesC), and to molluscan-bryozoan, eutrophic inner- to outer-shelf environments (minimum temperature 13.7 degreesC). The Gulf of California data, supplemented with oceanographic and compositional information from a database compiled from a spectrum of modern carbonate systems worldwide, demonstrates the significance of nutrient control in the formation of heterozoan, photozoan, and transitional heterozoan-photozoan carbonate systems and serves as a basis for more accurately interpreting fossil carbonates
Y1 - 2004
SN - 0091-7613
ER -
TY - JOUR
A1 - Wirth, Jonas
A1 - Hatter, Nino
A1 - Drost, Robert
A1 - Umbach, Tobias R.
A1 - Barja, Sara
A1 - Zastrow, Matthias
A1 - Rück-Braun, Karola
A1 - Pascual, Jose Ignacio
A1 - Saalfrank, Peter
A1 - Franke, Katharina J.
T1 - Diarylethene Molecules on a Ag(111) Surface: Stability and Electron-Induced Switching
JF - The journal of physical chemistry : C, Nanomaterials and interfaces
N2 - Diarylethene derivatives are photochromic molecular switches, undergoing a ring-opening/-closing reaction by illumination with light. The symmetry of the closed form is determined by the WoodWard Hoffinann rules according to which the reaction proceeds by corirotatory rotation -in that case. Here, we show by a cOrnbined approach of scanning tunneling microscopy (STM) and density functional theory (DFT) calculations that the Open isomer of 4,4'-(4,4'-(perfluorocydopent-1-ene-1,2-diyl)bis(5-methyl-thiophent-4,2,4-dipyridine) (PDTE) retains its open form upon adsorption on a Ag(111) surface. It caribe switched into a closed form, which we identify as the digrotatOly cydization product, by controlled manipulation 'With the STM tip, Evidence of an electric-field dependent switching-process 'is interpreted on the basis of a Simple electroStatic Model, which suggests that the reaction proceedS via an "upright" intermediate state. This pathway thus strongly differs from the switching reaction in solution.
Y1 - 2015
U6 - https://doi.org/10.1021/jp5122036
SN - 1932-7447
VL - 119
IS - 9
SP - 4874
EP - 4883
PB - American Chemical Society
CY - Washington
ER -
TY - JOUR
A1 - Lopez-Tarazon, Jose Andres
A1 - Batalla Villanueva, Ramon J.
A1 - Vericat, Damia
A1 - Francke, Till
T1 - The sediment budget of a highly dynamic mesoscale catchment the River Isabena
JF - Geomorphology : an international journal on pure and applied geomorphology
N2 - The paper presents the sediment budget of the Isabena basin, a highly dynamic 445-km(2) catchment located in the Central Pyrenees that is patched by highly erodible areas (i.e., badlands). The budget for the period 2007-2009 is constructed following a methodology that allows the interpolation of intermittent measurements of suspended sediment concentrations and enables a subsequent calculation of sediment loads. Data allow specification of the contribution of each subbasin to the water and sediment yield in the catchment outlet. Mean annual sediment load was 235,000 t y(-1). Specific sediment yield reached 2000 t km(-2) y(-1), a value that indicates very high sedimentary activity, especially in the case of Villacarli and Lascuarre subcatchments, were most badlands are located. The specific sediment yield obtained for the entire Isabena is 527 t km(-2) y(-1), a high value for such a mesoscale basin. Results show that a small part of the area (i.e., 1%) controls most of the catchment's gross sediment contribution. Sediment delivery ratio (ratio between sediment input from primary sources and basin export) has been estimated at around 90%, while in-channel storage represents the 5% of the annual load on average. The high connectivity between sediment sources (i.e., badlands) and transfer paths (i.e., streamcourses) exacerbates the influence of the local sediment production on the catchment's sediment yield, a quite unusual fact for a basin of this scale.
KW - Sediment budget
KW - Sediment transport
KW - Random forests
KW - Quantile regression forests
KW - River Isabena
KW - Ebro basin
Y1 - 2012
U6 - https://doi.org/10.1016/j.geomorph.2011.08.020
SN - 0169-555X
VL - 138
IS - 1
SP - 15
EP - 28
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - López-Tarazón, José Andrés
A1 - Batalla Villanueva, Ramon J.
A1 - Vericat, Damià
A1 - Francke, Till
T1 - Suspended sediment transport in a highly erodible catchment : the River Isábena (Southern Pyrenees)
N2 - Understanding and quantifying sediment load is important in catchments draining highly erodible materials that eventually contribute to siltation of downstream reservoirs. Within this context, the suspended sediment transport and its temporal dynamics have been studied in the River Isabena (445 km(2), south-central Pyrenees, Ebro basin) by means of direct sampling and turbidity recording during a 3-year dry period. The average flood-suspended sediment concentration was 8 g l(-1). with maximum instantaneous values above 350 g l(-1). The high scatter between discharge and suspended sediment concentrations (up to five orders of magnitude) has not permitted the use of rating curve methods to estimate the total load. Interpolation techniques yielded a mean annual sediment load of 184,253 t y(-1) for the study period, with a specific yield of 414 t km(-2) y(-1). This value resembles those reported for small torrents in nearby mountainous environments and is the result of the high connectivity between the badland source areas and stream courses, a fact that maximises sediment conveyance through the catchment. Floods dominated the sediment transport and yield. However, sediment transport was more constant through time than that observed in Mediterranean counterparts; this can be attributed to the role of base flows that entrain fine sediment temporarily stored in the channel and force the river to carry high sediment concentrations (i.e., generally in the order of 0.5 g l(-1)), even under minimum flow conditions.
Y1 - 2009
UR - http://www.sciencedirect.com/science/journal/0169555X
U6 - https://doi.org/10.1016/j.geomorph.2009.03.003
SN - 0169-555X
ER -
TY - JOUR
A1 - Boers, Niklas
A1 - Barbosa, Henrique M. J.
A1 - Bookhagen, Bodo
A1 - Marengo, Jose A.
A1 - Marwan, Norbert
A1 - Kurths, Jürgen
T1 - Propagation of Strong Rainfall Events from Southeastern South America to the Central Andes
JF - Journal of climate
N2 - Based on high-spatiotemporal-resolution data, the authors perform a climatological study of strong rainfall events propagating from southeastern South America to the eastern slopes of the central Andes during the monsoon season. These events account for up to 70% of total seasonal rainfall in these areas. They are of societal relevance because of associated natural hazards in the form of floods and landslides, and they form an intriguing climatic phenomenon, because they propagate against the direction of the low-level moisture flow from the tropics. The responsible synoptic mechanism is analyzed using suitable composites of the relevant atmospheric variables with high temporal resolution. The results suggest that the low-level inflow from the tropics, while important for maintaining sufficient moisture in the area of rainfall, does not initiate the formation of rainfall clusters. Instead, alternating low and high pressure anomalies in midlatitudes, which are associated with an eastward-moving Rossby wave train, in combination with the northwestern Argentinean low, create favorable pressure and wind conditions for frontogenesis and subsequent precipitation events propagating from southeastern South America toward the Bolivian Andes.
KW - Cold air surges
KW - Extreme events
KW - Precipitation
KW - Subtropical cyclones
KW - Convective storms
KW - Mesoscale systems
Y1 - 2015
U6 - https://doi.org/10.1175/JCLI-D-15-0137.1
SN - 0894-8755
SN - 1520-0442
VL - 28
IS - 19
SP - 7641
EP - 7658
PB - American Meteorological Soc.
CY - Boston
ER -
TY - JOUR
A1 - Wiedmer, Petra
A1 - Jung, Tobias
A1 - Castro, Jose Pedro
A1 - Pomatto, Laura C. D.
A1 - Sun, Patrick Y.
A1 - Davies, Kelvin J. A.
A1 - Grune, Tilman
T1 - Sarcopenia
BT - molecular mechanisms and open questions
JF - Ageing research reviews : ARR
N2 - Sarcopenia represents a muscle-wasting syndrome characterized by progressive and generalized degenerative loss of skeletal muscle mass, quality, and strength occurring during normal aging. Sarcopenia patients are mainly suffering from the loss in muscle strength and are faced with mobility disorders reducing their quality of life and are, therefore, at higher risk for morbidity (falls, bone fracture, metabolic diseases) and mortality.
Several molecular mechanisms have been described as causes for sarcopenia that refer to very different levels of muscle physiology. These mechanisms cover e. g. function of hormones (e. g. IGF-1 and Insulin), muscle fiber composition and neuromuscular drive, myo-satellite cell potential to differentiate and proliferate, inflammatory pathways as well as intracellular mechanisms in the processes of proteostasis and mitochondrial function.
In this review, we describe sarcopenia as a muscle-wasting syndrome distinct from other atrophic diseases and summarize the current view on molecular causes of sarcopenia development as well as open questions provoking further research efforts for establishing efficient lifestyle and therapeutic interventions.
KW - molecular pathways
KW - proteostasis
KW - proteasome
KW - autophagy
KW - mitochondria,
KW - muscle fibre composition
Y1 - 2020
U6 - https://doi.org/10.1016/j.arr.2020.101200
SN - 1568-1637
SN - 1872-9649
VL - 65
PB - Elsevier
CY - Clare
ER -
TY - JOUR
A1 - Reeg, Sandra
A1 - Jung, Tobias
A1 - Castro, José Pedro
A1 - Davies, Kelvin J. A.
A1 - Henze, Andrea
A1 - Grune, Tilman
T1 - The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome
JF - Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research
N2 - One hallmark of aging is the accumulation of protein aggregates, promoted by the unfolding of oxidized proteins. Unraveling the mechanism by which oxidized proteins are degraded may provide a basis to delay the early onset of features, such as protein aggregate formation, that contribute to the aging phenotype. In order to prevent aggregation of oxidized proteins, cells recur to the 20S proteasome, an efficient turnover proteolysis complex. It has previously been shown that upon oxidative stress the 26S proteasome, another form, dissociates into the 20S form. A critical player implicated in its dissociation is the Heat Shock Protein 70 (Hsp70), which promotes an increase in free 20S proteasome and, therefore, an increased capability to degrade oxidized proteins. The aim of this study was to test whether or not Hsp70 is involved in cooperating with the 20S proteasome for a selective degradation of oxidatively damaged proteins. Our results demonstrate that Hsp70 expression is induced in HT22 cells as a result of mild oxidative stress conditions. Furthermore, Hsp70 prevents the accumulation of oxidized proteins and directly promotes their degradation by the 20S proteasome. In contrast the expression of the Heat shock cognate protein 70 (Hsc70) was not changed in recovery after oxidative stress and Hsc70 has no influence on the removal of oxidatively damaged proteins. We were able to demonstrate in HT22 cells, in brain homogenates from 129/SV mice and in vitro, that there is an increased interaction of Hsp70 with oxidized proteins, but also with the 20S proteasome, indicating a role of Hsp70 in mediating the interaction of oxidized proteins with the 20S proteasome. Thus, our data clearly implicate an involvement of Hsp70 oxidatively damaged protein degradation by the 20S proteasome. c) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
KW - Protein oxidation
KW - Proteasome
KW - Chaperone
KW - HSP70
Y1 - 2016
U6 - https://doi.org/10.1016/j.freeradbiomed.2016.08.002
SN - 0891-5849
SN - 1873-4596
VL - 99
SP - 153
EP - 166
PB - Elsevier
CY - New York
ER -
TY - JOUR
A1 - Francke, Till
A1 - Förster, Saskia
A1 - Brosinsky, Arlena
A1 - Sommerer, Erik
A1 - Lopez-Tarazonl, Jose Andres
A1 - Güntner, Andreas
A1 - Batalla, Ramon J.
A1 - Bronstert, Axel
T1 - Water and sediment fluxes in Mediterranean mountainous regions
BT - comprehensive dataset for hydro-sedimentological analyses and modelling in a mesoscale catchment (River Isabena, NE Spain)
JF - Earth System Science Data
N2 - A comprehensive hydro-sedimentological dataset for the Isabena catchment, northeastern (NE) Spain, for the period 2010-2018 is presented to analyse water and sediment fluxes in a Mediterranean mesoscale catchment. The dataset includes rainfall data from 12 rain gauges distributed within the study area complemented by meteorological data of 12 official meteo-stations. It comprises discharge data derived from water stage measurements as well as suspended sediment concentrations (SSCs) at six gauging stations of the River Isabena and its sub-catchments. Soil spectroscopic data from 351 suspended sediment samples and 152 soil samples were collected to characterize sediment source regions and sediment properties via fingerprinting analyses. The Isabena catchment (445 km(2)) is located in the southern central Pyrenees ranging from 450 m to 2720 m a.s.l.; together with a pronounced topography, this leads to distinct temperature and precipitation gradients. The River Isabena shows marked discharge variations and high sediment yields causing severe siltation problems in the downstream Barasona Reservoir. The main sediment source is badland areas located on Eocene marls that are well connected to the river network. The dataset features a comprehensive set of variables in a high spatial and temporal resolution suitable for the advanced process understanding of water and sediment fluxes, their origin and connectivity and sediment budgeting and for the evaluation and further development of hydro-sedimentological models in Mediterranean mesoscale mountainous catchments.
Y1 - 2018
U6 - https://doi.org/10.5194/essd-10-1063-2018
SN - 1866-3508
SN - 1866-3516
VL - 10
IS - 2
SP - 1063
EP - 1075
PB - Copernicus
CY - Göttingen
ER -
TY - JOUR
A1 - Prieske, Olaf
A1 - Aboodarda, Saied J.
A1 - Sierra, Jose A. Benitez
A1 - Behm, David G.
A1 - Granacher, Urs
T1 - Slower but not faster unilateral fatiguing knee extensions alter contralateral limb performance without impairment of maximal torque output
JF - European journal of applied physiology
N2 - The purpose of the present study was to examine the effects of unilateral fatigue of the knee extensors at different movement velocities on neuromuscular performance in the fatigued and non-fatigued leg. Unilateral fatigue of the knee extensors was induced in 11 healthy young men (23.7 +/- 3.8 years) at slower (60A degrees/s; FAT60) and faster movement velocities (240A degrees/s; FAT240) using an isokinetic dynamometer. A resting control (CON) condition was included. The fatigue protocols consisted of five sets of 15 maximal concentric knee extensions using the dominant leg. Before and after fatigue, peak isokinetic torque (PIT) and time to PIT (TTP) of the knee extensors as well as electromyographic (EMG) activity of vastus medialis, vastus lateralis, and biceps femoris muscles were assessed at 60 and 240A degrees/s movement velocities in the fatigued and non-fatigued leg. In the fatigued leg, significantly greater PIT decrements were observed following FAT60 and FAT240 (11-19%) compared to CON (3-4%, p = .002, d = 2.3). Further, EMG activity increased in vastus lateralis and biceps femoris muscle following FAT240 only (8-28%, 0.018 <= p <=.024, d = 1.8). In the non-fatigued leg, shorter TTP values were found after the FAT60 protocol (11-15%, p = .023, d = 2.4). No significant changes were found for EMG data in the non-fatigued leg. The present study revealed that both slower and faster velocity fatiguing contractions failed to show any evidence of cross-over fatigue on PIT. However, unilateral knee extensor fatigue protocols conducted at slower movement velocities (i.e., 60A degrees/s) appear to modulate torque production on the non-fatigued side (evident in shorter TTP values).
KW - Electromyography
KW - Cross-over fatigue
KW - Isokinetic
KW - Movement velocity
KW - Motor function
KW - Central activation
Y1 - 2017
U6 - https://doi.org/10.1007/s00421-016-3524-6
SN - 1439-6319
SN - 1439-6327
VL - 117
SP - 323
EP - 334
PB - Springer
CY - New York
ER -
TY - JOUR
A1 - Khudair, Mohammed
A1 - Marcuzzi, Anna
A1 - Ng, Kwok
A1 - Tempest, Gavin Daniel
A1 - Bartoš, František
A1 - Peric, Ratko
A1 - Maier, Maximilian
A1 - Beccia, Flavia
A1 - Boccia, Stefania
A1 - Brandes, Mirko
A1 - Cardon, Greet
A1 - Carlin, Angela
A1 - Castagna, Carolina
A1 - Chaabene, Helmi
A1 - Chalkley, Anna
A1 - Ciaccioni, Simone
A1 - Cieślińska-Świder, Joanna
A1 - Čingienė, Vilma
A1 - Cortis, Cristina
A1 - Corvino, Chiara
A1 - de Geus, Eco J. C.
A1 - Di Baldassarre, Angela
A1 - Di Credico, Andrea
A1 - Drid, Patrik
A1 - Tarazaga, Rosa Ma Fernández
A1 - Gallè, Francesca
A1 - Sánchez, Esther Garcia
A1 - Gebremariam, Mekdes
A1 - Ghinassi, Barbara
A1 - Goudas, Marios
A1 - Hayes, Grainne
A1 - Honorio, Samuel
A1 - Izzicupo, Pascal
A1 - Jahre, Henriette
A1 - Jelsma, Judith
A1 - Juric, Petra
A1 - Kolovelonis, Athanasios
A1 - Kongsvold, Atle
A1 - Kouidi, Evangelia
A1 - Mansergh, Fiona
A1 - Masanovic, Bojan
A1 - Mekonnen, Teferi
A1 - Mork, Paul Jarle
A1 - Murphy, Marie
A1 - O'Hara, Kelly
A1 - Torun, Ayse Ozbil
A1 - Palumbo, Federico
A1 - Popovic, Stevo
A1 - Prieske, Olaf
A1 - Puharic, Zrinka
A1 - Ribeiro, José Carlos
A1 - Rumbold, Penny Louise Sheena
A1 - Sandu, Petru
A1 - Soric, Maroje
A1 - Stavnsbo, Mette
A1 - Syrmpas, Ioannis
A1 - van der Ploeg, Hidde P.
A1 - Van Hoye, Aurélie
A1 - Vilela, Sofia
A1 - Woods, Catherine
A1 - Wunsch, Kathrin
A1 - Caprinica, Laura
A1 - MacDonncha, Ciaran
A1 - Ling, Fiona Chun Man
T1 - DE-PASS Best Evidence Statement (BESt): modifiable determinants of physical activity and sedentary behaviour in children and adolescents aged 5-19 years-a protocol for systematic review and meta-analysis
JF - BMJ open
N2 - Introduction Physical activity among children and adolescents remains insufficient, despite the substantial efforts made by researchers and policymakers. Identifying and furthering our understanding of potential modifiable determinants of physical activity behaviour (PAB) and sedentary behaviour (SB) is crucial for the development of interventions that promote a shift from SB to PAB. The current protocol details the process through which a series of systematic literature reviews and meta-analyses (MAs) will be conducted to produce a best-evidence statement (BESt) and inform policymakers. The overall aim is to identify modifiable determinants that are associated with changes in PAB and SB in children and adolescents (aged 5-19 years) and to quantify their effect on, or association with, PAB/SB. Methods and analysis A search will be performed in MEDLINE, SportDiscus, Web of Science, PsychINFO and Cochrane Central Register of Controlled Trials. Randomised controlled trials (RCTs) and controlled trials (CTs) that investigate the effect of interventions on PAB/SB and longitudinal studies that investigate the associations between modifiable determinants and PAB/SB at multiple time points will be sought. Risk of bias assessments will be performed using adapted versions of Cochrane's RoB V.2.0 and ROBINS-I tools for RCTs and CTs, respectively, and an adapted version of the National Institute of Health's tool for longitudinal studies. Data will be synthesised narratively and, where possible, MAs will be performed using frequentist and Bayesian statistics. Modifiable determinants will be discussed considering the settings in which they were investigated and the PAB/SB measurement methods used. Ethics and dissemination No ethical approval is needed as no primary data will be collected. The findings will be disseminated in peer-reviewed publications and academic conferences where possible. The BESt will also be shared with policy makers within the DE-PASS consortium in the first instance. Systematic review registration CRD42021282874.
KW - public health
KW - health policy
KW - community child health
Y1 - 2022
U6 - https://doi.org/10.1136/bmjopen-2021-059202
SN - 2044-6055
VL - 12
IS - 9
PB - BMJ Publishing Group
CY - London
ER -
TY - GEN
A1 - Francke, Till
A1 - Förster, Saskia
A1 - Brosinsky, Arlena
A1 - Sommerer, Erik
A1 - Lopez-Tarazon, Jose Andres
A1 - Güntner, Andreas
A1 - Batalla Villanueva, Ramon J.
A1 - Bronstert, Axel
T1 - Water and sediment fluxes in Mediterranean mountainous regions
BT - comprehensive dataset for hydro-sedimentological analyses and modelling in a mesoscale catchment (River Isábena, NE Spain)
T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2 - A comprehensive hydro-sedimentological dataset for the Isábena catchment, northeastern (NE) Spain, for the period 2010–2018 is presented to analyse water and sediment fluxes in a Mediterranean mesoscale catchment. The dataset includes rainfall data from 12 rain gauges distributed within the study area complemented by meteorological data of 12 official meteo-stations. It comprises discharge data derived from water stage measurements as well as suspended sediment concentrations (SSCs) at six gauging stations of the River Isábena and its sub-catchments. Soil spectroscopic data from 351 suspended sediment samples and 152 soil samples were collected to characterize sediment source regions and sediment properties via fingerprinting analyses. The Isábena catchment (445 km 2 ) is located in the southern central Pyrenees ranging from 450 m to 2720 m a.s.l.; together with a pronounced topography, this leads to distinct temperature and precipitation gradients. The River Isábena shows marked discharge variations and high sediment yields causing severe siltation problems in the downstream Barasona Reservoir. The main sediment source is badland areas located on Eocene marls that are well connected to the river network. The dataset features a comprehensive set of variables in a high spatial and temporal resolution suitable for the advanced process understanding of water and sediment fluxes, their origin and connectivity and sediment budgeting and for the evaluation and further development of hydro-sedimentological models in
Mediterranean mesoscale mountainous catchments.
T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 547
KW - source siscrimination
KW - transport
KW - pyrenees
KW - connectivity
KW - sischarge
KW - runoff
KW - yield
Y1 - 2019
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-419150
SN - 1866-8372
IS - 547
ER -
TY - INPR
A1 - de Araujo, Jose Carlos
A1 - Batalla Villanueva, Ramon J.
A1 - Bronstert, Axel
T1 - Special issue: analysis and modelling of sediment transfer in Mediterranean river basins
T2 - Journal of soils and sediments : protection, risk assessment and remediation
Y1 - 2014
U6 - https://doi.org/10.1007/s11368-014-1000-7
SN - 1439-0108
SN - 1614-7480
VL - 14
IS - 12
SP - 1905
EP - 1908
PB - Springer
CY - Heidelberg
ER -
TY - JOUR
A1 - Hagberg, Linda
A1 - Celemin, Enrique
A1 - Irisarri, Iker
A1 - Hawlitschek, Oliver
A1 - Bella, Jose L.
A1 - Mott, Tami
A1 - Pereira, Ricardo J.
T1 - Extensive introgression at late stages of species formation
BT - insights from grasshopper hybrid zones
JF - Molecular ecology
N2 - The process of species formation is characterized by the accumulation of multiple reproductive barriers. The evolution of hybrid male sterility, or Haldane's rule, typically characterizes later stages of species formation, when reproductive isolation is strongest.
Yet, understanding how quickly reproductive barriers evolve and their consequences for maintaining genetic boundaries between emerging species remains a challenging task because it requires studying taxa that hybridize in nature.
Here, we address these questions using the meadow grasshopper Pseudochorthippus parallelus, where populations that show multiple reproductive barriers, including hybrid male sterility, hybridize in two natural hybrid zones. Using mitochondrial data, we infer that such populations diverged some 100,000 years ago, at the beginning of the last glacial cycle in Europe.
Nuclear data show that contractions at multiple glacial refugia, and post-glacial expansions have facilitated genetic differentiation between lineages that today interact in hybrid zones.
We find extensive introgression throughout the sampled species range, irrespective of the current strength of reproductive isolation. Populations exhibiting hybrid male sterility in two hybrid zones show repeatable patterns of genomic differentiation, consistent with shared genomic constraints affecting ancestral divergence or with the role of those regions in reproductive isolation.
Together, our results suggest that reproductive barriers that characterize late stages of species formation can evolve relatively quickly, particularly when associated with strong demographic changes. Moreover, we show that such barriers persist in the face of extensive gene flow, allowing future studies to identify associated genomic regions.
KW - Haldane's rule
KW - hybridization
KW - Pseudochorthippus parallelus
KW - speciation
KW - sterility
Y1 - 2022
U6 - https://doi.org/10.1111/mec.16406
SN - 0962-1083
SN - 1365-294X
VL - 31
IS - 8
SP - 2384
EP - 2399
PB - Wiley
CY - Hoboken
ER -
TY - GEN
A1 - Krause, Andreas
A1 - Kloft, Charlotte
A1 - Huisinga, Wilhelm
A1 - Karlsson, Mats
A1 - Pinheiro, José
A1 - Bies, Robert
A1 - Rogers, James
A1 - Mentré, France
A1 - Musser, Bret J.
T1 - Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development
T2 - Pharmaceutical statistics : the journal of applied statistics in the pharmaceutical industry
Y1 - 2019
SN - 1539-1604
SN - 1539-1612
VL - 18
IS - 3
SP - 278
EP - 281
PB - Wiley
CY - Hoboken
ER -
TY - JOUR
A1 - Marquer, Laurent
A1 - Gaillard, Marie-Jose
A1 - Sugita, Shinya
A1 - Poska, Anneli
A1 - Trondman, Anna-Kari
A1 - Mazier, Florence
A1 - Nielsen, Anne Birgitte
A1 - Fyfe, Ralph M.
A1 - Jonsson, Anna Maria
A1 - Smith, Benjamin
A1 - Kaplan, Jed O.
A1 - Alenius, Teija
A1 - Birks, H. John B.
A1 - Bjune, Anne E.
A1 - Christiansen, Jorg
A1 - Dodson, John
A1 - Edwards, Kevin J.
A1 - Giesecke, Thomas
A1 - Herzschuh, Ulrike
A1 - Kangur, Mihkel
A1 - Koff, Tiiu
A1 - Latalowa, Maligorzata
A1 - Lechterbeck, Jutta
A1 - Olofsson, Jorgen
A1 - Seppa, Heikki
T1 - Quantifying the effects of land use and climate on Holocene vegetation in Europe
JF - Quaternary science reviews : the international multidisciplinary research and review journal
N2 - Early agriculture can be detected in palaeovegetation records, but quantification of the relative importance of climate and land use in influencing regional vegetation composition since the onset of agriculture is a topic that is rarely addressed. We present a novel approach that combines pollen-based REVEALS estimates of plant cover with climate, anthropogenic land-cover and dynamic vegetation modelling results. This is used to quantify the relative impacts of land use and climate on Holocene vegetation at a sub-continental scale, i.e. northern and western Europe north of the Alps. We use redundancy analysis and variation partitioning to quantify the percentage of variation in vegetation composition explained by the climate and land-use variables, and Monte Carlo permutation tests to assess the statistical significance of each variable. We further use a similarity index to combine pollen based REVEALS estimates with climate-driven dynamic vegetation modelling results. The overall results indicate that climate is the major driver of vegetation when the Holocene is considered as a whole and at the sub-continental scale, although land use is important regionally. Four critical phases of land-use effects on vegetation are identified. The first phase (from 7000 to 6500 BP) corresponds to the early impacts on vegetation of farming and Neolithic forest clearance and to the dominance of climate as a driver of vegetation change. During the second phase (from 4500 to 4000 BP), land use becomes a major control of vegetation. Climate is still the principal driver, although its influence decreases gradually. The third phase (from 2000 to 1500 BP) is characterised by the continued role of climate on vegetation as a consequence of late-Holocene climate shifts and specific climate events that influence vegetation as well as land use. The last phase (from 500 to 350 BP) shows an acceleration of vegetation changes, in particular during the last century, caused by new farming practices and forestry in response to population growth and industrialization. This is a unique signature of anthropogenic impact within the Holocene but European vegetation remains climatically sensitive and thus may continue to respond to ongoing climate change. (C) 2017 Elsevier Ltd. All rights reserved.
KW - Climate
KW - Holocene
KW - Human impact
KW - Land use
KW - LPJ-GUESS
KW - Europe
KW - Pollen
KW - REVEALS
KW - Vegetation composition
Y1 - 2017
U6 - https://doi.org/10.1016/j.quascirev.2017.07.001
SN - 0277-3791
VL - 171
SP - 20
EP - 37
PB - Elsevier
CY - Oxford
ER -
TY - JOUR
A1 - Marquer, Laurent
A1 - Gaillard, Marie-Jose
A1 - Sugita, Shinya
A1 - Trondman, Anna-Kari
A1 - Mazier, Florence
A1 - Nielsen, Anne Birgitte
A1 - Fyfe, Ralph M.
A1 - Odgaard, Bent Vad
A1 - Alenius, Teija
A1 - Birks, H. John B.
A1 - Bjune, Anne E.
A1 - Christiansen, Jörg
A1 - Dodson, John
A1 - Edwards, Kevin J.
A1 - Giesecke, Thomas
A1 - Herzschuh, Ulrike
A1 - Kangur, Mihkel
A1 - Lorenz, Sebastian
A1 - Poska, Anneli
A1 - Schult, Manuela
A1 - Seppa, Heikki
T1 - Holocene changes in vegetation composition in northern Europe: why quantitative pollen-based vegetation reconstructions matter
JF - Quaternary science reviews : the international multidisciplinary research and review journal
N2 - We present pollen-based reconstructions of the spatio-temporal dynamics of northern European regional vegetation abundance through the Holocene. We apply the Regional Estimates of VEgetation Abundance from Large Sites (REVEALS) model using fossil pollen records from eighteen sites within five modern biomes in the region. The eighteen sites are classified into four time-trajectory types on the basis of principal components analysis of both the REVEALS-based vegetation estimates (RVs) and the pollen percentage (PPs). The four trajectory types are more clearly separated for RVs than PPs. Further, the timing of major Holocene shifts, rates of compositional change, and diversity indices (turnover and evenness) differ between RVs and PPs. The differences are due to the reduction by REVEALS of biases in fossil pollen assemblages caused by different basin size, and inter-taxonomic differences in pollen productivity and dispersal properties. For example, in comparison to the PPs, the RVs show an earlier increase in Corylus and Ulmus in the early-Holocene and a more pronounced increase in grassland and deforested areas since the mid-Holocene. The results suggest that the influence of deforestation and agricultural activities on plant composition and abundance from Neolithic times was stronger than previously inferred from PPs. Relative to PPs, RVs show a more rapid compositional change, a largest decrease in turnover, and less variable evenness in most of northern Europe since 5200 cal yr BP. All these changes are primarily related to the strong impact of human activities on the vegetation. This study demonstrates that RV-based estimates of diversity indices, timing of shifts, and rates of change in reconstructed vegetation provide new insights into the timing and magnitude of major human distribution on Holocene regional, vegetation, feature that are critical in the assessment of human impact on vegetation, land-cover, biodiversity, and climate in the past.
KW - Holocene
KW - Human impact
KW - Northern Europe
KW - Pollen
KW - Quantitative regional plant abundance
KW - Rate of compositional change
KW - REVEALS (Regional Estimates of VEgetation
KW - Abundance from Large Sites) model
KW - Vegetation diversity indices
Y1 - 2014
U6 - https://doi.org/10.1016/j.quascirev.2014.02.013
SN - 0277-3791
VL - 90
SP - 199
EP - 216
PB - Elsevier
CY - Oxford
ER -
TY - JOUR
A1 - Stanton, Richard A.
A1 - Boone, Wesley W.
A1 - Soto-Shoender, Jose
A1 - Fletcher, Robert J.
A1 - Blaum, Niels
A1 - McCleery, Robert A.
T1 - Shrub encroachment and vertebrate diversity
BT - a global meta-analysis
JF - Global ecology and biogeography : a journal of macroecology
N2 - Aim: Across the planet, grass-dominated biomes are experiencing shrub encroachment driven by atmospheric CO2 enrichment and land-use change. By altering resource structure and availability, shrub encroachment may have important impacts on vertebrate communities. We sought to determine the magnitude and variability of these effects across climatic gradients, continents, and taxa, and to learn whether shrub thinning restores the structure of vertebrate communities. Location: Worldwide. Time period: Contemporary. Major taxa studied: Terrestrial vertebrates. Methods: We estimated relationships between percentage shrub cover and the structure of terrestrial vertebrate communities (species richness, Shannon diversity and community abundance) in experimentally thinned and unmanipulated shrub-encroached grass-dominated biomes using systematic review and meta-analyses of 43 studies published from 1978 to 2016. We modelled the effects of continent, biome, mean annual precipitation, net primary productivity and the normalized difference vegetation index (NDVI) on the relationship between shrub cover and vertebrate community structure. Results: Species richness, Shannon diversity and total abundance had no consistent relationship with shrub encroachment and experimental thinning did not reverse encroachment effects on vertebrate communities. However, some effects of shrub encroachment on vertebrate communities differed with net primary productivity, amongst vertebrate groups, and across continents. Encroachment had negative effects on vertebrate diversity at low net primary productivity. Mammalian and herpetofaunal diversity decreased with shrub encroachment. Shrub encroachment also had negative effects on species richness and total abundance in Africa but positive effects in North America. Main conclusions: Biodiversity conservation and mitigation efforts responding to shrub encroachment should focus on low-productivity locations, on mammals and herpetofauna, and in Africa. However, targeted research in neglected regions such as central Asia and India will be needed to fill important gaps in our knowledge of shrub encroachment effects on vertebrates. Additionally, our findings provide an impetus for determining the mechanisms associated with changes in vertebrate diversity and abundance in shrub-encroached grass-dominated biomes.
KW - biodiversity
KW - global change
KW - grasslands
KW - grazing
KW - pastoral abandonment
KW - savannas
KW - shrub encroachment
KW - shrub thinning
KW - species richness
KW - woody encroachment
Y1 - 2017
U6 - https://doi.org/10.1111/geb.12675
SN - 1466-822X
SN - 1466-8238
VL - 27
IS - 3
SP - 368
EP - 379
PB - Wiley
CY - Hoboken
ER -
TY - JOUR
A1 - Stolterfoht, Martin
A1 - Wolff, Christian Michael
A1 - Marquez, Jose A.
A1 - Zhang, Shanshan
A1 - Hages, Charles J.
A1 - Rothhardt, Daniel
A1 - Albrecht, Steve
A1 - Burn, Paul L.
A1 - Meredith, Paul
A1 - Unold, Thomas
A1 - Neher, Dieter
T1 - Visualization and suppression of interfacial recombination for high-efficiency large-area pin perovskite solar cells
JF - Nature Energy
N2 - The performance of perovskite solar cells is predominantly limited by non-radiative recombination, either through trap-assisted recombination in the absorber layer or via minority carrier recombination at the perovskite/transport layer interfaces. Here, we use transient and absolute photoluminescence imaging to visualize all non-radiative recombination pathways in planar pintype perovskite solar cells with undoped organic charge transport layers. We find significant quasi-Fermi-level splitting losses (135 meV) in the perovskite bulk, whereas interfacial recombination results in an additional free energy loss of 80 meV at each individual interface, which limits the open-circuit voltage (V-oc) of the complete cell to similar to 1.12 V. Inserting ultrathin interlayers between the perovskite and transport layers leads to a substantial reduction of these interfacial losses at both the p and n contacts. Using this knowledge and approach, we demonstrate reproducible dopant-free 1 cm(2) perovskite solar cells surpassing 20% efficiency (19.83% certified) with stabilized power output, a high V-oc (1.17 V) and record fill factor (>81%).
KW - Energy science and technology
KW - Solar cells
Y1 - 2018
U6 - https://doi.org/10.1038/s41560-018-0219-8
SN - 2058-7546
VL - 3
IS - 10
SP - 847
EP - 854
PB - Nature Publ. Group
CY - London
ER -
TY - JOUR
A1 - Pablo, Herbert
A1 - Richardson, Noel D.
A1 - Moffat, Anthony F. J.
A1 - Corcoran, Michael
A1 - Shenar, Tomer
A1 - Benvenuto, Omar
A1 - Fuller, Jim
A1 - Naze, Yael
A1 - Hoffman, Jennifer L.
A1 - Miroshnichenko, Anatoly
A1 - Apellaniz, Jesus Maiz
A1 - Evans, Nancy
A1 - Eversberg, Thomas
A1 - Gayley, Ken
A1 - Gull, Ted
A1 - Hamaguchi, Kenji
A1 - Hamann, Wolf-Rainer
A1 - Henrichs, Huib
A1 - Hole, Tabetha
A1 - Ignace, Richard
A1 - Iping, Rosina
A1 - Lauer, Jennifer
A1 - Leutenegger, Maurice
A1 - Lomax, Jamie
A1 - Nichols, Joy
A1 - Oskinova, Lidia M.
A1 - Owocki, Stan
A1 - Pollock, Andy
A1 - Russell, Christopher M. P.
A1 - Waldron, Wayne
A1 - Buil, Christian
A1 - Garrel, Thierry
A1 - Graham, Keith
A1 - Heathcote, Bernard
A1 - Lemoult, Thierry
A1 - Li, Dong
A1 - Mauclaire, Benjamin
A1 - Potter, Mike
A1 - Ribeiro, Jose
A1 - Matthews, Jaymie
A1 - Cameron, Chris
A1 - Guenther, David
A1 - Kuschnig, Rainer
A1 - Rowe, Jason
A1 - Rucinski, Slavek
A1 - Sasselov, Dimitar
A1 - Weiss, Werner
T1 - A coordinated X-Ray and optical campaign of the nearest massive eclipsing binary, delta ORIONIS Aa. III. Analysis of optical photometric (most) and spectroscopic (ground based) variations
JF - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2 - We report on both high-precision photometry from the Microvariability and Oscillations of Stars (MOST) space telescope and ground-based spectroscopy of the triple system delta Ori A, consisting of a binary O9.5II+early-B (Aa1 and Aa2) with P = 5.7 days, and a more distant tertiary (O9 IV P > 400 years). This data was collected in concert with X-ray spectroscopy from the Chandra X-ray Observatory. Thanks to continuous coverage for three weeks, the MOST light curve reveals clear eclipses between Aa1 and Aa2 for the first time in non-phased data. From the spectroscopy, we have a well-constrained radial velocity (RV) curve of Aa1. While we are unable to recover RV variations of the secondary star, we are able to constrain several fundamental parameters of this system and determine an approximate mass of the primary using apsidal motion. We also detected second order modulations at 12 separate frequencies with spacings indicative of tidally influenced oscillations. These spacings have never been seen in a massive binary, making this system one of only a handful of such binaries that show evidence for tidally induced pulsations.
KW - binaries: close
KW - binaries: eclipsing
KW - stars: early-type
KW - stars: individual (delta Ori A)
KW - stars: mass-loss
KW - stars: variables: general
Y1 - 2015
U6 - https://doi.org/10.1088/0004-637X/809/2/134
SN - 0004-637X
SN - 1538-4357
VL - 809
IS - 2
PB - IOP Publ. Ltd.
CY - Bristol
ER -