TY - JOUR A1 - Gancheva, Sofiya A1 - Ouni, Meriem A1 - Jelenik, Tomas A1 - Koliaki, Chrysi A1 - Szendroedi, Julia A1 - Toledo, Frederico G. S. A1 - Markgraf, Daniel Frank A1 - Pesta, Dominik H. A1 - Mastrototaro, Lucia A1 - De Filippo, Elisabetta A1 - Herder, Christian A1 - Jähnert, Markus A1 - Weiss, Jürgen A1 - Strassburger, Klaus A1 - Schlensak, Matthias A1 - Schürmann, Annette A1 - Roden, Michael T1 - Dynamic changes of muscle insulin sensitivity after metabolic surgery JF - Nature Communications N2 - The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity. Y1 - 2019 U6 - https://doi.org/10.1038/s41467-019-12081-0 SN - 2041-1723 VL - 10 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Cuzzi, Jeff N. A1 - Burns, Joseph A. A1 - Charnoz, Sébastien A1 - Clark, Roger N. A1 - Colwell, Josh E. A1 - Dones, Luke A1 - Esposito, Larry W. A1 - Filacchione, Gianrico A1 - French, Richard G. A1 - Hedman, Matthew M. A1 - Kempf, Sascha A1 - Marouf, Essam A. A1 - Murray, Carl D. A1 - Nicholson, Phillip D. A1 - Porco, Carolyn C. A1 - Schmidt, Jürgen A1 - Showalter, Mark R. A1 - Spilker, Linda J. A1 - Spitale, Joseph N. A1 - Srama, Ralf A1 - Sremcević, Miodrag A1 - Tiscareno, Matthew Steven A1 - Weiss, John T1 - An evolving view of Saturn's dynamic rings N2 - We review our understanding of Saturn's rings after nearly 6 years of observations by the Cassini spacecraft. Saturn's rings are composed mostly of water ice but also contain an undetermined reddish contaminant. The rings exhibit a range of structure across many spatial scales; some of this involves the interplay of the fluid nature and the self-gravity of innumerable orbiting centimeter- to meter-sized particles, and the effects of several peripheral and embedded moonlets, but much remains unexplained. A few aspects of ring structure change on time scales as short as days. It remains unclear whether the vigorous evolutionary processes to which the rings are subject imply a much younger age than that of the solar system. Processes on view at Saturn have parallels in circumstellar disks. Y1 - 2010 UR - http://www.sciencemag.org/ U6 - https://doi.org/10.1126/science.1179118 SN - 0036-8075 ER - TY - CHAP A1 - Laschewsky, André A1 - Liang, Hua A1 - Rabe, Jürgen P. A1 - Skrabania, Katja A1 - Stahlhut, Frank A1 - Weiss, Jan A1 - Zehm, Daniel T1 - Molecularly designed polymer colloids From giant surfactants to multicompartment micelles T2 - Abstracts of papers : joint conference / The Chemical Institute of Cananda, CIC, American Chemical Society, ACS Y1 - 2012 SN - 0065-7727 VL - 244 IS - 32 PB - American Chemical Society CY - Washington ER - TY - GEN A1 - Wardelmann, Kristina A1 - Rath, Michaela A1 - Castro, José Pedro A1 - Blümel, Sabine A1 - Schell, Mareike A1 - Hauffe, Robert A1 - Schumacher, Fabian A1 - Flore, Tanina A1 - Ritter, Katrin A1 - Wernitz, Andreas A1 - Hosoi, Toru A1 - Ozawa, Koichiro A1 - Kleuser, Burkhard A1 - Weiß, Jürgen A1 - Schürmann, Annette A1 - Kleinridders, André T1 - Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism and insulin sensitivity in the hypothalamus T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregulated mitochondrial stress response (MSR) with reduced chaperone expression in the hypothalamus is an early event in obesity development due to insufficient insulin signaling. Although insulin activates this response and improves metabolism, the metabolic impact of one of its members, the mitochondrial chaperone heat shock protein 10 (Hsp10), is unknown. Thus, we hypothesized that a reduction of Hsp10 in hypothalamic neurons will impair mitochondrial function and impact brain insulin action. Therefore, we investigated the role of chaperone Hsp10 by introducing a lentiviral-mediated Hsp10 knockdown (KD) in the hypothalamic cell line CLU-183 and in the arcuate nucleus (ARC) of C57BL/6N male mice. We analyzed mitochondrial function and insulin signaling utilizing qPCR, Western blot, XF96 Analyzer, immunohistochemistry, and microscopy techniques. We show that Hsp10 expression is reduced in T2D mice brains and regulated by leptin in vitro. Hsp10 KD in hypothalamic cells induced mitochondrial dysfunction with altered fatty acid metabolism and increased mitochondria-specific oxidative stress resulting in neuronal insulin resistance. Consequently, the reduction of Hsp10 in the ARC of C57BL/6N mice caused hypothalamic insulin resistance with acute liver insulin resistance. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1165 KW - brain insulin signaling KW - mitochondria KW - oxidative stress KW - fatty acid metabolism Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-522985 SN - 1866-8372 IS - 5 ER - TY - JOUR A1 - Wardelmann, Kristina A1 - Rath, Michaela A1 - Castro, José Pedro A1 - Blümel, Sabine A1 - Schell, Mareike A1 - Hauffe, Robert A1 - Schumacher, Fabian A1 - Flore, Tanina A1 - Ritter, Katrin A1 - Wernitz, Andreas A1 - Hosoi, Toru A1 - Ozawa, Koichiro A1 - Kleuser, Burkhard A1 - Weiß, Jürgen A1 - Schürmann, Annette A1 - Kleinridders, André T1 - Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism and insulin sensitivity in the hypothalamus JF - Antioxidants N2 - Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregulated mitochondrial stress response (MSR) with reduced chaperone expression in the hypothalamus is an early event in obesity development due to insufficient insulin signaling. Although insulin activates this response and improves metabolism, the metabolic impact of one of its members, the mitochondrial chaperone heat shock protein 10 (Hsp10), is unknown. Thus, we hypothesized that a reduction of Hsp10 in hypothalamic neurons will impair mitochondrial function and impact brain insulin action. Therefore, we investigated the role of chaperone Hsp10 by introducing a lentiviral-mediated Hsp10 knockdown (KD) in the hypothalamic cell line CLU-183 and in the arcuate nucleus (ARC) of C57BL/6N male mice. We analyzed mitochondrial function and insulin signaling utilizing qPCR, Western blot, XF96 Analyzer, immunohistochemistry, and microscopy techniques. We show that Hsp10 expression is reduced in T2D mice brains and regulated by leptin in vitro. Hsp10 KD in hypothalamic cells induced mitochondrial dysfunction with altered fatty acid metabolism and increased mitochondria-specific oxidative stress resulting in neuronal insulin resistance. Consequently, the reduction of Hsp10 in the ARC of C57BL/6N mice caused hypothalamic insulin resistance with acute liver insulin resistance. KW - brain insulin signaling KW - mitochondria KW - oxidative stress KW - fatty acid metabolism Y1 - 2021 U6 - https://doi.org/10.3390/antiox10050711 SN - 2076-3921 VL - 10 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Hedrich, Klaus-Jürgen A1 - Weiß, Norman T1 - Die Rolle Deutschlands in der multilateralen Entwicklungszusammenarbeit unter besonderer Berücksichtigung der entwicklungspolitischen Ergebnisse des UN-Millenniumgipfels JF - Bilanz ein Jahr nach dem Millennium : Reformkonzepte und deren Implementierung N2 - Die Rolle Deutschlands in der multilateralen Entwicklungszusammenarbeit unter besonderer Berücksichtigung der entwicklungspolitischen Ergebnisse des UN-Millenniumsgipfels // Klaus-Jürgen Hedrich I. Akteure und Strukturen der multilateralen Entwicklungszusammenarbeit II. Entwicklungspolitik der Vereinten Nationen III. Der Milleniums-Gipfel der Vereinten Nationen Multilaterale Organisationen und neue Formen der internationalenEntwicklungszusammenarbeit / Die Rolle Deutschlandsin der multilateralen Entwicklungszusammenarbeit —Diskussionszusammenfassung // Norman Weiß Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102195 VL - 2001 IS - 2 SP - 83 EP - 92 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - BOOK A1 - Bormann, Stephan A1 - Brunotte, Rene A1 - Bülow, Alexander A1 - Dörfler, Joachim A1 - Forner, Andreas A1 - Hafer, Gebhard A1 - Karth, Nina A1 - Klein, Ingo A1 - Kleinwächter, Lutz A1 - Lucht, Dietmar A1 - Peche, Norbert A1 - Schössler, Julia A1 - Weiß, Jürgen T1 - Die bbw Hochschule der Wirtschaft für die Wirtschaft Y1 - 2013 SN - 978-3-941880-76-4 PB - WeltTrends CY - Potsdam ER - TY - CHAP A1 - Papenfuß, Anja A1 - Maier, Jürgen A1 - Weiß, Norman A1 - Fitschen, Thomas T1 - Die Rolle der Vereinten Nationen in der multilateralen Entwicklungszusammenarbeit BT - 13. Potsdamer UNO-Konferenz am 25. Juni 2016 T2 - Potsdamer UNO-Konferenzen N2 - Der Forschungskreis Vereinte Nationen veranstaltete am 25. Juni 2016 seine dreizehnte Konferenz in Kooperation mit dem „Forum internationale Ordnung“ des Auswärtigen Amtes. Die Potsdamer UNO-Konferenzen stellen in ihrem Programm traditionell eine Verbindung von Wissenschaft und Praxis her unter Beteiligung unterschiedlicher Disziplinen. Die Konferenz 2016 widmete sich dem Thema „Die Rolle der Vereinten Nationen in der multilateralen Entwicklungszusammenarbeit“. Entwicklung als wichtiges Ziel der Vereinten Nationen und ihrer Mitgliedstaaten ist auch für andere Handlungs- und Politikfelder wichtig. Bilanz und Ausblick, die auf der Konferenz unternommen wurden, betrafen deshalb nicht nur die Entwicklungspolitik im eigentlichen Sinne – hier standen die 2015 beschlossenen Nachhaltigkeitsziele (SDGs) zur Debatte –, sondern bezogen auch umweltpolitische und menschenrechtliche Aspekte mit ein. Die Referate zum Thema Entwicklung wurden eingerahmt von zwei Vorträgen zu aktuellen UN-politischen Fragen: der Wahl des neuen Generalsekretärs der Vereinten Nationen in New York nach einem reformierten Wahlverfahren, das mehr Transparenz und für UN-Mitgliedstaaten und NGOs mehr Beteiligungsmöglichkeiten bietet, und die Neuorganisation innerhalb des Auswärtigen Amtes, was die Vereinten Nationen betrifft. T3 - Potsdamer UNO-Konferenzen - 12 Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-395190 SN - 978-3-86956-402-9 SN - 1617-4704 IS - 12 PB - Universitätsverlag Potsdam CY - Potsdam ER -