TY - JOUR A1 - Mortensen, Alicja A1 - Kulling, Sabine E. A1 - Schwartz, Heidi A1 - Rowland, Ian A1 - Ruefer, Corinna E. A1 - Rimbach, Gerald A1 - Cassidy, Aedin A1 - Magee, Pamela A1 - Millar, Julie A1 - Hall, Wendy L. A1 - Kramer Birkved, Franziska A1 - Sorensen, Ilona K. A1 - Sontag, Gerhard T1 - Analytical and compositional aspects of isoflavones in food and their biological effects N2 - This paper provides an overview of analytical techniques used to determine isoflavones (IFs) in foods and biological fluids with main emphasis on sample preparation methods. Factors influencing the content of IFs in food including processing and natural variability are summarized and an insight into IF databases is given. Comparisons of dietary intake of IFs in Asian and Western populations, in special subgroups like vegetarians, vegans, and infants are made and our knowledge on their absorption, distribution, metabolism, and excretion by the human body is presented. The influences of the gut microflora, age, gender, background diet, food matrix, and the chemical nature of the IFs on the metabolism of IFs are described. Potential mechanisms by which IFs may exert their actions are reviewed, and genetic polymorphism as determinants of biological response to soy IFs is discussed. The effects of IFs on a range of health outcomes including atherosclerosis, breast, intestinal, and prostate cancers, menopausal symptoms, bone health, and cognition are reviewed on the basis of the available in vitro, in vivo animal and human data. Y1 - 2009 UR - http://www3.interscience.wiley.com/cgi-bin/jhome/109582333 U6 - https://doi.org/10.1002/mnfr.200800478 SN - 1613-4125 ER - TY - JOUR A1 - Blayney, Tamsin A1 - Dupont-Nivet, Guillaume A1 - Najman, Yani A1 - Proust, Jean-Noel A1 - Meijer, Niels A1 - Roperch, Pierrick A1 - Sobel, Edward A1 - Millar, Ian A1 - Guo, Zhaojie T1 - Tectonic Evolution of the Pamir Recorded in the Western Tarim Basin (China) BT - Sedimentologic and Magnetostratigraphic Analyses of the Aertashi Section JF - Tectonics N2 - The northward indentation of the Pamir salient into the Tarim basin at the western syntaxis of the India-Asia collision zone is the focus of controversial models linking lithospheric to surface and atmospheric processes. Here we report on tectonic events recorded in the most complete and best-dated sedimentary sequences from the western Tarim basin flanking the eastern Pamir (the Aertashi section), based on sedimentologic, provenance, and magnetostratigraphic analyses. Increased tectonic subsidence and a shift from marine to continental fluvio-deltaic deposition at 41Ma indicate that far-field deformation from the south started to affect the Tarim region. A sediment accumulation hiatus from 24.3 to 21.6Ma followed by deposition of proximal conglomerates is linked to fault propagation into the Tarim basin. From 21.6 to 15.0Ma, increasing accumulation rates of fining upward clastics is interpreted as the expression of a major dextral transtensional system linking the Kunlun to the Tian Shan ahead of the northward Pamir indentation. At 15.0Ma, the appearance of North Pamir-sourced conglomerates followed at 11Ma by Central Pamir-sourced volcanics coincides with a shift to E-W compression, clockwise vertical-axis rotations and the onset of growth strata associated with the activation of the local east vergent Qimugen thrust wedge. Together, this enables us to interpret that Pamir indentation into Tarim had started by 24.3Ma, reached the study location by 15.0Ma and had passed it by 11Ma, providing kinematic constraints on proposed tectonic models involving intracontinental subduction and delamination. KW - India-Asia collision KW - Tarim basin KW - Pamir KW - Cenozoic KW - paleomagnetism KW - sedimentology Y1 - 2019 U6 - https://doi.org/10.1029/2018TC005146 SN - 0278-7407 SN - 1944-9194 VL - 38 IS - 2 SP - 492 EP - 515 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Zhang, Peng A1 - Najman, Yani A1 - Mei, Lianfu A1 - Millar, Ian A1 - Sobel, Edward A1 - Carter, Andrew A1 - Barfod, Dan A1 - Dhuime, Bruno A1 - Garzanti, Eduardo A1 - Govin, Gwladys A1 - Vezzoli, Giovanni A1 - Hu, Xiaolin T1 - Palaeodrainage evolution of the large rivers of East Asia, and Himalayan-Tibet tectonics JF - Earth science reviews N2 - A number of sedimentary provenance studies have been undertaken in order to determine whether the palaeo-Red River was once a river of continental proportions into which the upper reaches of the Yangtze, Salween, Mekong, Irrawaddy, and Yarlung drained. We have assessed the evidence that the Yarlung originally flowed into the palaeo-Red river, and then sequentially into the Irrawaddy and Brahmaputra, connecting to the latter first via the Lohit and then the Siang. For this river system, we have integrated our new data from the Paleogene-Recent Irrawaddy drainage basin (detrital zircon U-Pb with Hf and fission track, rutile U-Pb, mica Ar-Ar, bulk rock Sr-Nd, and petrography) with previously published data, to produce a palaeodrainage model that is consistent with all datasets. In our model, the Yarlung never flowed into the Irrawaddy drainage: during the Paleogene, the Yarlung suture zone was an internally drained basin, and from Neogene times onwards the Yarlung drained into the Brahmaputra in the Bengal Basin. The Central Myanmar Basin, through which the Irrawaddy River flows today, received predominantly locally-derived detritus until the Middle Eocene, the Irrawaddy initiated as a through-going river draining the Mogok Metamorphic Belt and Bomi-Chayu granites to the north sometime in the Late Eocene to Early Oligocene, and the river was dominated by a stable MMB-dominated drainage throughout the Neogene to present day. Existing evidence does not support any connection between the Yarlung and the Red River in the past, but there is a paucity of suitable palaeo-Red River deposits with which to make a robust comparison. We argue that this limitation also precludes a robust assessment of a palaeo-connection between the Yangtze/ Salween/Mekong and the Red River; it is difficult to unequivocally interpret the recorded provenance changes as the result of specific drainage reorganisations. We highlight the palaeo-Red River deposits of the Hanoi Basin as a potential location for future research focus in view of the near-complete Cenozoic record of palaeo-Red River deposits at this location. A majority of previous studies consider that if a major continental-scale drainage ever existed at all, it fragmented early in the Cenozoic. Such a viewpoint would agree with the growing body of evidence from palaeoaltitude studies that large parts of SE Tibet were uplifted by this period. This then leads towards the intriguing question as to the mechanisms which caused the major period of river incision in the Miocene in this region. KW - Eastern Tibet KW - Palaeodrainage KW - Red River KW - Irrawaddy River KW - Yarlung Tsangpo KW - Central Myanmar Basin Y1 - 2019 U6 - https://doi.org/10.1016/j.earscirev.2019.02.003 SN - 0012-8252 SN - 1872-6828 VL - 192 SP - 601 EP - 630 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Blayney, Tamsin A1 - Najman, Yani A1 - Dupont-Nivet, Guillaume A1 - Carter, Andrew A1 - Millar, Ian A1 - Garzanti, Eduardo A1 - Sobel, Edward A1 - Rittner, Martin A1 - Ando, Sergio A1 - Guo, Zhaojie A1 - Vezzoli, Giovanni T1 - Indentation of the Pamirs with respect to the northern margin of Tibet: Constraints from the Tarim basin sedimentary record JF - Tectonics N2 - The Pamirs represent the indented westward continuation of the northern margin of the Tibetan Plateau, dividing the Tarim and Tajik basins. Their evolution may be a key factor influencing aridification of the Asian interior, yet the tectonics of the Pamir Salient are poorly understood. We present a provenance study of the Aertashi section, a Paleogene to late Neogene clastic succession deposited in the Tarim basin to the north of the NW margin of Tibet (the West Kunlun) and to the east of the Pamirs. Our detrital zircon U-Pb ages coupled with zircon fission track, bulk rock Sm-Nd, and petrography data document changes in contributing source terranes during the Oligocene to Miocene, which can be correlated to regional tectonics. We propose a model for the evolution of the Pamir and West Kunlun (WKL), in which the WKL formed topography since at least similar to 200 Ma. By similar to 25 Ma, movement along the Pamir-bounding faults such as the Kashgar-Yecheng Transfer System had commenced, marking the onset of Pamir indentation into the Tarim-Tajik basin. This is coincident with basinward expansion of the northern WKL margin, which changed the palaeodrainage pattern within the Kunlun, progressively cutting off the more southerly WKL sources from the Tarim basin. An abrupt change in the provenance and facies of sediments at Aertashi has a maximum age of 14 Ma; this change records when the Pamir indenter had propagated sufficiently far north that the North Pamir was now located proximal to the Aertashi region. Y1 - 2016 U6 - https://doi.org/10.1002/2016TC004222 SN - 0278-7407 SN - 1944-9194 VL - 35 SP - 2345 EP - 2369 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Hülscher, Julian A1 - Sobel, Edward A1 - Kallnik, Niklas A1 - Hoffmann, J. Elis A1 - Millar, Ian L. A1 - Hartmann, Kai A1 - Bernhardt, Anne T1 - Apatites record sedimentary provenance change 4-5 myrs before clay in the Oligocene/Miocene Alpine molasse JF - Frontiers in Earth Science N2 - Extracting information about past tectonic or climatic environmental changes from sedimentary records is a key objective of provenance research. Interpreting the imprint of such changes remains challenging as signals might be altered in the sediment-routing system. We investigate the sedimentary provenance of the Oligocene/Miocene Upper Austrian Northern Alpine Foreland Basin and its response to the tectonically driven exhumation of the Tauern Window metamorphic dome (28 +/- 1 Ma) in the Eastern European Alps by using the unprecedented combination of Nd isotopic composition of bulk-rock clay-sized samples and partly previously published multi-proxy (Nd isotopic composition, trace-element geochemistry, U-Pb dating) sand-sized apatite single-grain analysis. The basin offers an excellent opportunity to investigate environmental signal propagation into the sedimentary record because comprehensive stratigraphic and seismic datasets can be combined with present research results. The bulk-rock clay-sized fraction epsilon Nd values of well-cutting samples from one well on the northern basin slope remained stable at similar to-9.7 from 27 to 19 Ma but increased after 19 Ma to similar to-9.1. In contrast, apatite single-grain distributions, which were extracted from 22 drill-core samples, changed significantly around 23.3 Ma from apatites dominantly from low-grade (0.8-<8.8 +/- 2.4 Ma), and the Siang section (Middle Siwalik rocks at <9.3 +/- 1.5 to <13.5 +/- 1.5 Ma). Cretaceous-Paleogene detrital zircon and apatite U-Pb ages, characteristic of the Transhimalayan Gangdese Batholiths that crop out northwest of the syntaxis, are present throughout the Sibo, Remi, and Siang successions, confirming the existence of a Yarlung-Brahmaputra connection since at least the Late Miocene. A ca. 500 Ma zircon population increases up section, most strikingly sometime between 3.6 to 6.6 Ma, at the expense of Transhimalayan grains. We consider the ca. 500 Ma population to be derived from the Tethyan or Greater Himalaya, and we interpret the up-section increase to reflect progressive exhumation of the Namche Barwa syntaxis. Early Cretaceous zircon and apatite U-Pb ages are rare in the Sibo, Remi, and Siang successions, but abundant in modern Siang River sediments. Zircons of this age range are characteristic of the Transhimalayan Bomi-Chayu batholiths, which crop out east of the syntaxis and are eroded by the Parlung River, a modern tributary of the Siang River. We interpret the difference in relative abundance of Early Cretaceous zircons between the modern and ancient sediments to reflect capture of the Parlung by the Siang after 800 ka. KW - Himalaya KW - Siwaliks KW - Namche Barwa syntaxis KW - Brahmaputra River KW - Parlung River KW - detrital geochronology and thermochronology Y1 - 2018 U6 - https://doi.org/10.2475/07.2018.02 SN - 0002-9599 SN - 1945-452X VL - 318 IS - 7 SP - 764 EP - 798 PB - Kline Geology Laboratory, Yale University CY - New Haven ER -